Table of Contents

Biological Sciences

• Anthropology

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    Representation of stable social dominance relations by human infants

    Olivier Mascaro and Gergely Csibra

    PNAS May 1, 2012 109 (18) 6862-6867; https://doi.org/10.1073/pnas.1113194109
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    Nest-building orangutans demonstrate engineering know-how to produce safe, comfortable beds

    Adam van Casteren, William I. Sellers, Susannah K. S. Thorpe, Sam Coward, Robin H. Crompton, Julia P. Myatt, and A. Roland Ennos

    PNAS May 1, 2012 109 (18) 6873-6877; https://doi.org/10.1073/pnas.1200902109
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    Single amino acid radiocarbon dating of Upper Paleolithic modern humans

    • From the Cover

    Anat Marom, James S. O. McCullagh, Thomas F. G. Higham, Andrey A. Sinitsyn, and Robert E. M. Hedges

    PNAS May 1, 2012 109 (18) 6878-6881; https://doi.org/10.1073/pnas.1116328109
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    Juvenile hominoid cranium from the late Miocene of southern China and hominoid diversity in Asia

    Jay Kelley and Feng Gao

    PNAS May 1, 2012 109 (18) 6882-6885; https://doi.org/10.1073/pnas.1201330109

• Applied Biological Sciences

  • Open Access

    Tissue deformation spatially modulates VEGF signaling and angiogenesis

    Nicolas C. Rivron, Erik J. Vrij, Jeroen Rouwkema, Severine Le Gac, Albert van den Berg, Roman K. Truckenmüller, and Clemens A. van Blitterswijk

    PNAS May 1, 2012 109 (18) 6886-6891; https://doi.org/10.1073/pnas.1201626109

• Biochemistry

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    A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence

    Leslie Y. Beh, Lucy J. Colwell, and Nicole J. Francis

    PNAS May 1, 2012 109 (18) E1063-E1071; https://doi.org/10.1073/pnas.1118678109
  • Open Access

    Biologically relevant mechanism for catalytic superoxide removal by simple manganese compounds

    Kevin Barnese, Edith Butler Gralla, Joan Selverstone Valentine, and Diane E. Cabelli

    PNAS May 1, 2012 109 (18) 6892-6897; https://doi.org/10.1073/pnas.1203051109
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    Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy

    Hui Wei, Laiman Xiang, Alan S. Wayne, Oleg Chertov, David J. FitzGerald, Tapan K. Bera, and Ira Pastan

    PNAS May 1, 2012 109 (18) 6898-6903; https://doi.org/10.1073/pnas.1204523109
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    Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

    Jiangbin Ye, Anthony Mancuso, Xuemei Tong, Patrick S. Ward, Jing Fan, Joshua D. Rabinowitz, and Craig B. Thompson

    PNAS May 1, 2012 109 (18) 6904-6909; https://doi.org/10.1073/pnas.1204176109
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    Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

    Joanna L. Griffin, Matthew W. Bowler, Nicola J. Baxter, Katherine N. Leigh, Hugh R. W. Dannatt, Andrea M. Hounslow, G. Michael Blackburn, Charles Edwin Webster, Matthew J. Cliff, and Jonathan P. Waltho

    PNAS May 1, 2012 109 (18) 6910-6915; https://doi.org/10.1073/pnas.1116855109
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    Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail

    Hay Dvir, Mehul Shah, Enrico Girardi, Lixia Guo, Marilyn G. Farquhar, and Dirk M. Zajonc

    PNAS May 1, 2012 109 (18) 6916-6921; https://doi.org/10.1073/pnas.1114128109
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    ATP-independent substrate reduction by nitrogenase P-cluster variant

    Chi Chung Lee, Yilin Hu, and Markus W. Ribbe

    PNAS May 1, 2012 109 (18) 6922-6926; https://doi.org/10.1073/pnas.1202429109
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    BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

    Ballachanda N. Devaiah, Brian A. Lewis, Natasha Cherman, Michael C. Hewitt, Brian K. Albrecht, Pamela G. Robey, Keiko Ozato, Robert J. Sims III, and Dinah S. Singer

    PNAS May 1, 2012 109 (18) 6927-6932; https://doi.org/10.1073/pnas.1120422109

• Biophysics and Computational Biology

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    Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness

    Léa Trichet, Jimmy Le Digabel, Rhoda J. Hawkins, Sri Ram Krishna Vedula, Mukund Gupta, Claire Ribrault, Pascal Hersen, Raphaël Voituriez, and Benoît Ladoux

    PNAS May 1, 2012 109 (18) 6933-6938; https://doi.org/10.1073/pnas.1117810109
  • Open Access

    Designing biomimetic pores based on carbon nanotubes

    Rebeca García-Fandiño and Mark S. P. Sansom

    PNAS May 1, 2012 109 (18) 6939-6944; https://doi.org/10.1073/pnas.1119326109
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    Cavities determine the pressure unfolding of proteins

    • From the Cover

    Julien Roche, Jose A. Caro, Douglas R. Norberto, Philippe Barthe, Christian Roumestand, Jamie L. Schlessman, Angel E. Garcia, Bertrand García-Moreno E., and Catherine A. Royer

    PNAS May 1, 2012 109 (18) 6945-6950; https://doi.org/10.1073/pnas.1200915109

    See companion article:

    • Proteins under pressure

      - Apr 23, 2012
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    Intrinsic disorder modulates protein self-assembly and aggregation

    Alfonso De Simone, Craig Kitchen, Ann H. Kwan, Margaret Sunde, Christopher M. Dobson, and Daan Frenkel

    PNAS May 1, 2012 109 (18) 6951-6956; https://doi.org/10.1073/pnas.1118048109
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    Robustness and accuracy of cell division in Escherichia coli in diverse cell shapes

    Jaan Männik, Fabai Wu, Felix J. H. Hol, Paola Bisicchia, David J. Sherratt, Juan E. Keymer, and Cees Dekker

    PNAS May 1, 2012 109 (18) 6957-6962; https://doi.org/10.1073/pnas.1120854109

• Cell Biology

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    Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function

    Sungsu Kim, Sarah A. Naylor, and Aaron DiAntonio

    PNAS May 1, 2012 109 (18) E1072-E1081; https://doi.org/10.1073/pnas.1120320109
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    Coupling actin flow, adhesion, and morphology in a computational cell motility model

    Danying Shao, Herbert Levine, and Wouter-Jan Rappel

    PNAS May 1, 2012 109 (18) 6851-6856; https://doi.org/10.1073/pnas.1203252109
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    β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas

    Chunzhang Yang, Rajiv R. Iyer, Albert C. H. Yu, Raymund L. Yong, Deric M. Park, Robert J. Weil, Barbara Ikejiri, Roscoe O. Brady, Russell R. Lonser, and Zhengping Zhuang

    PNAS May 1, 2012 109 (18) 6963-6968; https://doi.org/10.1073/pnas.1118754109
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    Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca²⁺ oscillations and gene expression

    Pulak Kar, Daniel Bakowski, Joseph Di Capite, Charmaine Nelson, and Anant B. Parekh

    PNAS May 1, 2012 109 (18) 6969-6974; https://doi.org/10.1073/pnas.1201204109
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    Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression

    Jia Li, Xiaolei Liu, Huayan Wang, Weiping Zhang, David C. Chan, and Yuguang Shi

    PNAS May 1, 2012 109 (18) 6975-6980; https://doi.org/10.1073/pnas.1120043109
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    Regulation of selective autophagy onset by a Ypt/Rab GTPase module

    Zhanna Lipatova, Natalia Belogortseva, Xiu Qi Zhang, Jane Kim, David Taussig, and Nava Segev

    PNAS May 1, 2012 109 (18) 6981-6986; https://doi.org/10.1073/pnas.1121299109

• Developmental Biology

  • Open Access

    Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension

    Katja Dahlgaard, Anita Jung, Klaus Qvortrup, Henrik Clausen, Ole Kjaerulff, and Hans H. Wandall

    PNAS May 1, 2012 109 (18) 6987-6992; https://doi.org/10.1073/pnas.1115453109
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    Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling

    • From the Cover

    Linda Chang, Michela Noseda, Michelle Higginson, Michelle Ly, Alexandre Patenaude, Megan Fuller, Alastair H. Kyle, Andrew I. Minchinton, Mira C. Puri, Daniel J. Dumont, and Aly Karsan

    PNAS May 1, 2012 109 (18) 6993-6998; https://doi.org/10.1073/pnas.1118512109

• Ecology

  • Open Access

    Climate change and the selective signature of the Late Ordovician mass extinction

    Seth Finnegan, Noel A. Heim, Shanan E. Peters, and Woodward W. Fischer

    PNAS May 1, 2012 109 (18) 6829-6834; https://doi.org/10.1073/pnas.1117039109
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    Inoculation of bats with European Geomyces destructans supports the novel pathogen hypothesis for the origin of white-nose syndrome

    • From the Cover

    Lisa Warnecke, James M. Turner, Trent K. Bollinger, Jeffrey M. Lorch, Vikram Misra, Paul M. Cryan, Gudrun Wibbelt, David S. Blehert, and Craig K. R. Willis

    PNAS May 1, 2012 109 (18) 6999-7003; https://doi.org/10.1073/pnas.1200374109

    See companion article:

    • Bats and white-nose syndrome

      - Apr 19, 2012

• Environmental Sciences

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    Agulhas leakage as a key process in the modes of Quaternary climate changes

    Thibaut Caley, Jacques Giraudeau, Bruno Malaizé, Linda Rossignol, and Catherine Pierre

    PNAS May 1, 2012 109 (18) 6835-6839; https://doi.org/10.1073/pnas.1115545109
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    Global changes in diets and the consequences for land requirements for food

    Thomas Kastner, Maria Jose Ibarrola Rivas, Wolfgang Koch, and Sanderine Nonhebel

    PNAS May 1, 2012 109 (18) 6868-6872; https://doi.org/10.1073/pnas.1117054109

• Evolution

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    Predator-induced macroevolutionary trends in Mesozoic crinoids

    Przemysław Gorzelak, Mariusz A. Salamon, and Tomasz K. Baumiller

    PNAS May 1, 2012 109 (18) 7004-7007; https://doi.org/10.1073/pnas.1201573109
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    Tempo of trophic evolution and its impact on mammalian diversification

    Samantha A. Price, Samantha S. B. Hopkins, Kathleen K. Smith, and V. Louise Roth

    PNAS May 1, 2012 109 (18) 7008-7012; https://doi.org/10.1073/pnas.1117133109

• Genetics

  • Open Access

    Chronic restraint stress attenuates p53 function and promotes tumorigenesis

    Zhaohui Feng, Lianxin Liu, Cen Zhang, Tongsen Zheng, Jiabei Wang, Meihua Lin, Yuhan Zhao, Xiaowen Wang, Arnold J. Levine, and Wenwei Hu

    PNAS May 1, 2012 109 (18) 7013-7018; https://doi.org/10.1073/pnas.1203930109
  • Open Access

    Membrane binding of Escherichia coli RNase E catalytic domain stabilizes protein structure and increases RNA substrate affinity

    Oleg N. Murashko, Vladimir R. Kaberdin, and Sue Lin-Chao

    PNAS May 1, 2012 109 (18) 7019-7024; https://doi.org/10.1073/pnas.1120181109

• Immunology

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    Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apc^min mice by inhibiting IL-10 secretion and regulatory T-cell generation

    Oksana B. Serebrennikova, Christos Tsatsanis, Changchuin Mao, Elias Gounaris, Wenying Ren, Linda D. Siracusa, Aristides G. Eliopoulos, Khashayarsha Khazaie, and Philip N. Tsichlis

    PNAS May 1, 2012 109 (18) E1082-E1091; https://doi.org/10.1073/pnas.1115098109
  • Open Access

    Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity

    Jennifer D. Larson, Joshua M. Thurman, Anatoly V. Rubtsov, David Claypool, Philippa Marrack, Linda F. van Dyk, Raul M. Torres, and Roberta Pelanda

    PNAS May 1, 2012 109 (18) E1092-E1100; https://doi.org/10.1073/pnas.1203019109
  • Open Access

    MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA

    Brian P. Dolan, Aditi A. Sharma, James S. Gibbs, Tshaka J. Cunningham, Jack R. Bennink, and Jonathan W. Yewdell

    PNAS May 1, 2012 109 (18) 7025-7030; https://doi.org/10.1073/pnas.1112387109
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    The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia

    Rui Kang, Tara Loux, Daolin Tang, Nicole E. Schapiro, Philip Vernon, Kristen M. Livesey, Alyssa Krasinskas, Michael T. Lotze, and Herbert J. Zeh III

    PNAS May 1, 2012 109 (18) 7031-7036; https://doi.org/10.1073/pnas.1113865109
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    Long-lived epithelial immunity by tissue-resident memory T (T_RM) cells in the absence of persisting local antigen presentation

    Laura K. Mackay, Angus T. Stock, Joel Z. Ma, Claerwen M. Jones, Stephen J. Kent, Scott N. Mueller, William R. Heath, Francis R. Carbone, and Thomas Gebhardt

    PNAS May 1, 2012 109 (18) 7037-7042; https://doi.org/10.1073/pnas.1202288109
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    Langerhans cells down-regulate inflammation-driven alveolar bone loss

    Moran Arizon, Itay Nudel, Hadas Segev, Gabriel Mizraji, Mazal Elnekave, Karina Furmanov, Luba Eli-Berchoer, Björn E. Clausen, Lior Shapira, Asaf Wilensky, and Avi-Hai Hovav

    PNAS May 1, 2012 109 (18) 7043-7048; https://doi.org/10.1073/pnas.1116770109

• Medical Sciences

  • Open Access

    Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

    Yi-Ping Li, Santseharay Ramirez, Judith M. Gottwein, Troels K. H. Scheel, Lotte Mikkelsen, Robert H. Purcell, and Jens Bukh

    PNAS May 1, 2012 109 (18) E1101-E1110; https://doi.org/10.1073/pnas.1203829109
  • Open Access

    Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes

    Keiichi Kodama, Momoko Horikoshi, Kyoko Toda, Satoru Yamada, Kazuo Hara, Junichiro Irie, Marina Sirota, Alexander A. Morgan, Rong Chen, Hiroshi Ohtsu, Shiro Maeda, Takashi Kadowaki, and Atul J. Butte

    PNAS May 1, 2012 109 (18) 7049-7054; https://doi.org/10.1073/pnas.1114513109
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    Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor

    Huiyuan Zheng, Claire Worrall, Hongchang Shen, Tarik Issad, Stefan Seregard, Ada Girnita, and Leonard Girnita

    PNAS May 1, 2012 109 (18) 7055-7060; https://doi.org/10.1073/pnas.1118359109
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    General anesthesia alters time perception by phase shifting the circadian clock

    James F. Cheeseman, Eva C. Winnebeck, Craig D. Millar, Lisa S. Kirkland, James Sleigh, Mark Goodwin, Matt D. M. Pawley, Guy Bloch, Konstantin Lehmann, Randolf Menzel, and Guy R. Warman

    PNAS May 1, 2012 109 (18) 7061-7066; https://doi.org/10.1073/pnas.1201734109
  • Open Access

    Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis

    David De Semir, Mehdi Nosrati, Vladimir Bezrookove, Altaf A. Dar, Scot Federman, Geraldine Bienvenu, Suraj Venna, Javier Rangel, Joan Climent, Tanja M. Meyer Tamgüney, Suresh Thummala, Schuyler Tong, Stanley P. L. Leong, Chris Haqq, Paul Billings, James R. Miller III, Richard W. Sagebiel, Robert Debs, and Mohammed Kashani-Sabet

    PNAS May 1, 2012 109 (18) 7067-7072; https://doi.org/10.1073/pnas.1119949109

• Microbiology

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    Bacteriophage T4 polynucleotide kinase triggers degradation of mRNAs

    Sylvain Durand, Graziella Richard, François Bontems, and Marc Uzan

    PNAS May 1, 2012 109 (18) 7073-7078; https://doi.org/10.1073/pnas.1119802109
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    Snapshot of virus evolution in hypersaline environments from the characterization of a membrane-containing Salisaeta icosahedral phage 1

    Antti P. Aalto, David Bitto, Janne J. Ravantti, Dennis H. Bamford, Juha T. Huiskonen, and Hanna M. Oksanen

    PNAS May 1, 2012 109 (18) 7079-7084; https://doi.org/10.1073/pnas.1120174109
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    Refactoring the nitrogen fixation gene cluster from Klebsiella oxytoca

    Karsten Temme, Dehua Zhao, and Christopher A. Voigt

    PNAS May 1, 2012 109 (18) 7085-7090; https://doi.org/10.1073/pnas.1120788109

• Neuroscience

  • Open Access

    Link between orientation and retinotopic maps in primary visual cortex

    Se-Bum Paik and Dario L. Ringach

    PNAS May 1, 2012 109 (18) 7091-7096; https://doi.org/10.1073/pnas.1118926109

• Physiology

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    Dynamic migration of γδ intraepithelial lymphocytes requires occludin

    Karen L. Edelblum, Le Shen, Christopher R. Weber, Amanda M. Marchiando, Bryan S. Clay, Yingmin Wang, Immo Prinz, Bernard Malissen, Anne I. Sperling, and Jerrold R. Turner

    PNAS May 1, 2012 109 (18) 7097-7102; https://doi.org/10.1073/pnas.1112519109
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    Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels

    Jeremiah D. Osteen, Rene Barro-Soria, Seth Robey, Kevin J. Sampson, Robert S. Kass, and H. Peter Larsson

    PNAS May 1, 2012 109 (18) 7103-7108; https://doi.org/10.1073/pnas.1201582109

• Plant Biology

  • Open Access

    Heterosis of Arabidopsis hybrids between C24 and Col is associated with increased photosynthesis capacity

    Ryo Fujimoto, Jennifer M. Taylor, Sachiko Shirasawa, W. James Peacock, and Elizabeth S. Dennis

    PNAS May 1, 2012 109 (18) 7109-7114; https://doi.org/10.1073/pnas.1204464109
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    Molecular genetic basis of pod corn (Tunicate maize)

    Luzie U. Wingen, Thomas Münster, Wolfram Faigl, Wim Deleu, Hans Sommer, Heinz Saedler, and Günter Theißen

    PNAS May 1, 2012 109 (18) 7115-7120; https://doi.org/10.1073/pnas.1111670109

• Psychological and Cognitive Sciences

  • Open Access

    Test of a motor theory of long-term auditory memory

    Katrin Schulze, Faraneh Vargha-Khadem, and Mortimer Mishkin

    PNAS May 1, 2012 109 (18) 7121-7125; https://doi.org/10.1073/pnas.1204717109

• Sustainability Science

  • Open Access

    Extending the timescale and range of ecosystem services through paleoenvironmental analyses, exemplified in the lower Yangtze basin

    John A. Dearing, Xiangdong Yang, Xuhui Dong, Enlou Zhang, Xu Chen, Peter G. Langdon, Ke Zhang, Weiguo Zhang, and Terence P. Dawson

    PNAS May 1, 2012 109 (18) E1111-E1120; https://doi.org/10.1073/pnas.1118263109

• Systems Biology

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    Superessential reactions in metabolic networks

    Aditya Barve, João Frederico Matias Rodrigues, and Andreas Wagner

    PNAS May 1, 2012 109 (18) E1121-E1130; https://doi.org/10.1073/pnas.1113065109
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    The protein expression landscape of the Arabidopsis root

    • Inaugural Article

    Jalean J. Petricka, Monica A. Schauer, Molly Megraw, Natalie W. Breakfield, J. Will Thompson, Stoyan Georgiev, Erik J. Soderblom, Uwe Ohler, Martin Arthur Moseley, Ueli Grossniklaus, and Philip N. Benfey

    PNAS May 1, 2012 109 (18) 6811-6818; https://doi.org/10.1073/pnas.1202546109