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Biological Sciences

• Anthropology

  • Open Access

    No third-party punishment in chimpanzees

    Katrin Riedl, Keith Jensen, Josep Call, and Michael Tomasello

    PNAS September 11, 2012 109 (37) 14824-14829; https://doi.org/10.1073/pnas.1203179109

• Applied Biological Sciences

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    Targeting collagen strands by photo-triggered triple-helix hybridization

    Yang Li, Catherine A. Foss, Daniel D. Summerfield, Jefferson J. Doyle, Collin M. Torok, Harry C. Dietz, Martin G. Pomper, and S. Michael Yu

    PNAS September 11, 2012 109 (37) 14767-14772; https://doi.org/10.1073/pnas.1209721109

• Biochemistry

  • Open Access

    Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

    Sooncheol Lee, Botao Liu, Soohyun Lee, Sheng-Xiong Huang, Ben Shen, and Shu-Bing Qian

    PNAS September 11, 2012 109 (37) E2424-E2432; https://doi.org/10.1073/pnas.1207846109
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    Pyranopterin conformation defines the function of molybdenum and tungsten enzymes

    Richard A. Rothery, Benjamin Stein, Matthew Solomonson, Martin L. Kirk, and Joel H. Weiner

    PNAS September 11, 2012 109 (37) 14773-14778; https://doi.org/10.1073/pnas.1200671109
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    Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography

    Kalyaneswar Mandal, Maruti Uppalapati, Dana Ault-Riché, John Kenney, Joshua Lowitz, Sachdev S. Sidhu, and Stephen B.H. Kent

    PNAS September 11, 2012 109 (37) 14779-14784; https://doi.org/10.1073/pnas.1210483109
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    Structural basis for entropy-driven cellulose binding by a type-A cellulose-binding module (CBM) and bacterial expansin

    Nikolaos Georgelis, Neela H. Yennawar, and Daniel J. Cosgrove

    PNAS September 11, 2012 109 (37) 14830-14835; https://doi.org/10.1073/pnas.1213200109
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    Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell–cell adhesion

    Dibyendu Samanta, Udupi A. Ramagopal, Rotem Rubinstein, Vladimir Vigdorovich, Stanley G. Nathenson, and Steven C. Almo

    PNAS September 11, 2012 109 (37) 14836-14840; https://doi.org/10.1073/pnas.1212912109
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    Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli

    Abhishek Chatterjee, Han Xiao, and Peter G. Schultz

    PNAS September 11, 2012 109 (37) 14841-14846; https://doi.org/10.1073/pnas.1212454109
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    Dynamics of the l-fucose/H⁺ symporter revealed by fluorescence spectroscopy

    Junichi Sugihara, Linfeng Sun, Nieng Yan, and H. Ronald Kaback

    PNAS September 11, 2012 109 (37) 14847-14851; https://doi.org/10.1073/pnas.1213445109
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    Net −1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA

    Dongli Pan and Donald M. Coen

    PNAS September 11, 2012 109 (37) 14852-14857; https://doi.org/10.1073/pnas.1206582109
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    An insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis

    Yue Qiu, Claus Tittiger, Claude Wicker-Thomas, Gaëlle Le Goff, Sharon Young, Eric Wajnberg, Thierry Fricaux, Nathalie Taquet, Gary J. Blomquist, and René Feyereisen

    PNAS September 11, 2012 109 (37) 14858-14863; https://doi.org/10.1073/pnas.1208650109
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    MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability

    Benjamin Y. Jin, Alison J. Lin, David E. Golan, and Thomas Michel

    PNAS September 11, 2012 109 (37) 14864-14869; https://doi.org/10.1073/pnas.1204974109

• Biophysics and Computational Biology

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    Myosin IC generates power over a range of loads via a new tension-sensing mechanism

    Michael J. Greenberg, Tianming Lin, Yale E. Goldman, Henry Shuman, and E. Michael Ostap

    PNAS September 11, 2012 109 (37) E2433-E2440; https://doi.org/10.1073/pnas.1207811109
  • Open Access

    Near-atomic resolution structural model of the yeast 26S proteasome

    Florian Beck, Pia Unverdorben, Stefan Bohn, Andreas Schweitzer, Günter Pfeifer, Eri Sakata, Stephan Nickell, Jürgen M. Plitzko, Elizabeth Villa, Wolfgang Baumeister, and Friedrich Förster

    PNAS September 11, 2012 109 (37) 14870-14875; https://doi.org/10.1073/pnas.1213333109
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    Realistic simulations of the coupling between the protomotive force and the mechanical rotation of the F₀-ATPase

    Shayantani Mukherjee and Arieh Warshel

    PNAS September 11, 2012 109 (37) 14876-14881; https://doi.org/10.1073/pnas.1212841109
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    Structure and dynamics of protein waters revealed by radiolysis and mass spectrometry

    Sayan Gupta, Rhijuta D’Mello, and Mark R. Chance

    PNAS September 11, 2012 109 (37) 14882-14887; https://doi.org/10.1073/pnas.1209060109
  • Open Access

    Escape from Adaptive Conflict follows from weak functional trade-offs and mutational robustness

    Tobias Sikosek, Hue Sun Chan, and Erich Bornberg-Bauer

    PNAS September 11, 2012 109 (37) 14888-14893; https://doi.org/10.1073/pnas.1115620109
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    The Monod-Wyman-Changeux allosteric model accounts for the quaternary transition dynamics in wild type and a recombinant mutant human hemoglobin

    Matteo Levantino, Alessandro Spilotros, Marco Cammarata, Giorgio Schirò, Chiara Ardiccioni, Beatrice Vallone, Maurizio Brunori, and Antonio Cupane

    PNAS September 11, 2012 109 (37) 14894-14899; https://doi.org/10.1073/pnas.1205809109
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    Foldon unfolding mediates the interconversion between M^pro-C monomer and 3D domain-swapped dimer

    Xue Kang, Nan Zhong, Peng Zou, Shengnan Zhang, Changwen Jin, and Bin Xia

    PNAS September 11, 2012 109 (37) 14900-14905; https://doi.org/10.1073/pnas.1205241109

• Cell Biology

  • Open Access

    The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

    John M. Lamar, Patrick Stern, Hui Liu, Jeffrey W. Schindler, Zhi-Gang Jiang, and Richard O. Hynes

    PNAS September 11, 2012 109 (37) E2441-E2450; https://doi.org/10.1073/pnas.1212021109
  • Open Access

    Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures

    Helen R. Saibil, Anja Seybert, Anja Habermann, Juliane Winkler, Mikhail Eltsov, Mario Perkovic, Daniel Castaño-Diez, Margot P. Scheffer, Uta Haselmann, Petr Chlanda, Susan Lindquist, Jens Tyedmers, and Achilleas S. Frangakis

    PNAS September 11, 2012 109 (37) 14906-14911; https://doi.org/10.1073/pnas.1211976109
  • Open Access

    Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

    Annemieke T. van der Goot, Wentao Zhu, Rafael P. Vázquez-Manrique, Renée I. Seinstra, Katja Dettmer, Helen Michels, Francesca Farina, Jasper Krijnen, Ronald Melki, Rogier C. Buijsman, Mariana Ruiz Silva, Karen L. Thijssen, Ido P. Kema, Christian Neri, Peter J. Oefner, and Ellen A. A. Nollen

    PNAS September 11, 2012 109 (37) 14912-14917; https://doi.org/10.1073/pnas.1203083109

• Developmental Biology

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    An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development

    Miguel A. Hernández-Oñate, Edgardo U. Esquivel-Naranjo, Artemio Mendoza-Mendoza, Alison Stewart, and Alfredo H. Herrera-Estrella

    PNAS September 11, 2012 109 (37) 14918-14923; https://doi.org/10.1073/pnas.1209396109

• Ecology

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    Seasonal migration to high latitudes results in major reproductive benefits in an insect

    Jason W. Chapman, James R. Bell, Laura E. Burgin, Donald R. Reynolds, Lars B. Pettersson, Jane K. Hill, Michael B. Bonsall, and Jeremy A. Thomas

    PNAS September 11, 2012 109 (37) 14924-14929; https://doi.org/10.1073/pnas.1207255109

• Environmental Sciences

  • Open Access

    Soybean susceptibility to manufactured nanomaterials with evidence for food quality and soil fertility interruption

    • From the Cover

    John H. Priester, Yuan Ge, Randall E. Mielke, Allison M. Horst, Shelly Cole Moritz, Katherine Espinosa, Jeff Gelb, Sharon L. Walker, Roger M. Nisbet, Youn-Joo An, Joshua P. Schimel, Reid G. Palmer, Jose A. Hernandez-Viezcas, Lijuan Zhao, Jorge L. Gardea-Torresdey, and Patricia A. Holden

    PNAS September 11, 2012 109 (37) E2451-E2456; https://doi.org/10.1073/pnas.1205431109

    See companion article:

    • In This Issue

      - Sep 11, 2012

    See companion article:

    • Effects of manufactured nanomaterials to soybean

      - Nov 02, 2012
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    Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes

    Vanessa Delfosse, Marina Grimaldi, Jean-Luc Pons, Abdelhay Boulahtouf, Albane le Maire, Vincent Cavailles, Gilles Labesse, William Bourguet, and Patrick Balaguer

    PNAS September 11, 2012 109 (37) 14930-14935; https://doi.org/10.1073/pnas.1203574109

• Evolution

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    Arthropods in amber from the Triassic Period

    Alexander R. Schmidt, Saskia Jancke, Evert E. Lindquist, Eugenio Ragazzi, Guido Roghi, Paul C. Nascimbene, Kerstin Schmidt, Torsten Wappler, and David A. Grimaldi

    PNAS September 11, 2012 109 (37) 14796-14801; https://doi.org/10.1073/pnas.1208464109
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    Evolution of cooperation and skew under imperfect information

    Erol Akçay, Adam Meirowitz, Kristopher W. Ramsay, and Simon A. Levin

    PNAS September 11, 2012 109 (37) 14936-14941; https://doi.org/10.1073/pnas.1212925109
  • Open Access

    Resolving conflict in eutherian mammal phylogeny using phylogenomics and the multispecies coalescent model

    Sen Song, Liang Liu, Scott V. Edwards, and Shaoyuan Wu

    PNAS September 11, 2012 109 (37) 14942-14947; https://doi.org/10.1073/pnas.1211733109

    See companion article:

    • Accommodating gene tree heterogeneity

      - Mar 04, 2013

• Genetics

  • Open Access

    Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines

    • Inaugural Article

    James A. Birchler and Reiner A. Veitia

    PNAS September 11, 2012 109 (37) 14746-14753; https://doi.org/10.1073/pnas.1207726109

    See companion article:

    • In This Issue

      - Sep 11, 2012
    • Profile of James A. Birchler

      - Jan 23, 2013
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    Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice

    Chandrika Canugovi, Jeong Seon Yoon, Neil H. Feldman, Deborah L. Croteau, Mark P. Mattson, and Vilhelm A. Bohr

    PNAS September 11, 2012 109 (37) 14948-14953; https://doi.org/10.1073/pnas.1204156109

• Immunology

  • Open Access

    Antibodies and IL-3 support helminth-induced basophil expansion

    Tina Herbst, Julia Esser, Moira Prati, Manuel Kulagin, Rebecca Stettler, Mario M. Zaiss, James P. Hewitson, Patrick Merky, Joseph S. Verbeek, Carole Bourquin, Mali Camberis, Melanie Prout, Rick M. Maizels, Graham Le Gros, and Nicola L. Harris

    PNAS September 11, 2012 109 (37) 14954-14959; https://doi.org/10.1073/pnas.1117584109
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    Structural insights into the editing of germ-line–encoded interactions between T-cell receptor and MHC class II by Vα CDR3

    Lu Deng, Ries J. Langley, Qian Wang, Suzanne L. Topalian, and Roy A. Mariuzza

    PNAS September 11, 2012 109 (37) 14960-14965; https://doi.org/10.1073/pnas.1207186109

• Medical Sciences

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    Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription

    Mary L. Spengler, Karen K. Kuropatwinski, Maria Comas, Alexander V. Gasparian, Natalia Fedtsova, Anatoli S. Gleiberman, Ilya I. Gitlin, Natalia M. Artemicheva, Krysta A. Deluca, Andrei V. Gudkov, and Marina P. Antoch

    PNAS September 11, 2012 109 (37) E2457-E2465; https://doi.org/10.1073/pnas.1206274109
  • Open Access

    Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism

    Whitney H. Brown, Matthew P. Gillum, Hui-Young Lee, Joao Paulo G. Camporez, Xian-man Zhang, Jin Kwon Jeong, Tiago C. Alves, Derek M. Erion, Blas A. Guigni, Mario Kahn, Varman T. Samuel, Benjamin F. Cravatt, Sabrina Diano, and Gerald I. Shulman

    PNAS September 11, 2012 109 (37) 14966-14971; https://doi.org/10.1073/pnas.1212887109
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    Metabolic manifestations of insulin deficiency do not occur without glucagon action

    Young Lee, Eric D. Berglund, May-yun Wang, Xiaorong Fu, Xinxin Yu, Maureen J. Charron, Shawn C. Burgess, and Roger H. Unger

    PNAS September 11, 2012 109 (37) 14972-14976; https://doi.org/10.1073/pnas.1205983109

    See companion article:

    • In This Issue

      - Sep 11, 2012
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    Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome

    Paula J. Hurley, Luigi Marchionni, Brian W. Simons, Ashley E. Ross, Sarah B. Peskoe, Rebecca M. Miller, Nicholas Erho, Ismael A. Vergara, Mercedeh Ghadessi, Zhenhua Huang, Bora Gurel, Ben Ho Park, Elai Davicioni, Robert B. Jenkins, Elizabeth A. Platz, David M. Berman, and Edward M. Schaeffer

    PNAS September 11, 2012 109 (37) 14977-14982; https://doi.org/10.1073/pnas.1203525109
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    Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

    Driss El Kebir, Per Gjorstrup, and János G. Filep

    PNAS September 11, 2012 109 (37) 14983-14988; https://doi.org/10.1073/pnas.1206641109

• Microbiology

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    Structure–function analysis of pneumococcal DprA protein reveals that dimerization is crucial for loading RecA recombinase onto DNA during transformation

    Sophie Quevillon-Cheruel, Nathalie Campo, Nicolas Mirouze, Isabelle Mortier-Barrière, Mark A. Brooks, Marion Boudes, Dominique Durand, Anne-Lise Soulet, Johnny Lisboa, Philippe Noirot, Bernard Martin, Herman van Tilbeurgh, Marie-Françoise Noirot-Gros, Jean-Pierre Claverys, and Patrice Polard

    PNAS September 11, 2012 109 (37) E2466-E2475; https://doi.org/10.1073/pnas.1205638109
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    Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics

    • From the Cover

    Wen-Hsuan W. Lin, Roger D. Kouyos, Robert J. Adams, Bryan T. Grenfell, and Diane E. Griffin

    PNAS September 11, 2012 109 (37) 14989-14994; https://doi.org/10.1073/pnas.1211138109

    See companion article:

    • Measles immunometrics

      - Aug 30, 2012
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    Interactions between the termini of lumen enzymes and shell proteins mediate enzyme encapsulation into bacterial microcompartments

    Chenguang Fan, Shouqiang Cheng, Sharmistha Sinha, and Thomas A. Bobik

    PNAS September 11, 2012 109 (37) 14995-15000; https://doi.org/10.1073/pnas.1207516109
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    Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide

    Jacques Grosset, Deepak Almeida, Paul J. Converse, Sandeep Tyagi, Si-Yang Li, Nicole C. Ammerman, Alexander S. Pym, Kristina Wallengren, Richard Hafner, Umesh Lalloo, Susan Swindells, and William R. Bishai

    PNAS September 11, 2012 109 (37) 15001-15005; https://doi.org/10.1073/pnas.1203636109

• Neuroscience

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    Neural coding and perceptual detection in the primate somatosensory thalamus

    Yuriria Vázquez, Antonio Zainos, Manuel Alvarez, Emilio Salinas, and Ranulfo Romo

    PNAS September 11, 2012 109 (37) 15006-15011; https://doi.org/10.1073/pnas.1212535109
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    Retinal prosthetic strategy with the capacity to restore normal vision

    Sheila Nirenberg and Chethan Pandarinath

    PNAS September 11, 2012 109 (37) 15012-15017; https://doi.org/10.1073/pnas.1207035109
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    Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation

    Alessia Capotondo, Rita Milazzo, Letterio Salvatore Politi, Angelo Quattrini, Alessio Palini, Tiziana Plati, Stefania Merella, Alessandro Nonis, Clelia di Serio, Eugenio Montini, Luigi Naldini, and Alessandra Biffi

    PNAS September 11, 2012 109 (37) 15018-15023; https://doi.org/10.1073/pnas.1205858109
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    Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

    I-Fang Wang, Bo-Shen Guo, Yu-Chih Liu, Cheng-Chun Wu, Chun-Hung Yang, Kuen-Jer Tsai, and Che-Kun James Shen

    PNAS September 11, 2012 109 (37) 15024-15029; https://doi.org/10.1073/pnas.1206362109

• Pharmacology

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    Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects

    Carmel T. Chan, Robert E. Reeves, Ron Geller, Shahriar S. Yaghoubi, Aileen Hoehne, David E. Solow-Cordero, Gabriela Chiosis, Tarik F. Massoud, Ramasamy Paulmurugan, and Sanjiv S. Gambhir

    PNAS September 11, 2012 109 (37) E2476-E2485; https://doi.org/10.1073/pnas.1205459109
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    Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents

    Gabriele Zoppoli, Marie Regairaz, Elisabetta Leo, William C. Reinhold, Sudhir Varma, Alberto Ballestrero, James H. Doroshow, and Yves Pommier

    PNAS September 11, 2012 109 (37) 15030-15035; https://doi.org/10.1073/pnas.1205943109

• Physiology

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    Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum

    Jennifer R. Dwyer, Jimmy Donkor, Peixiang Zhang, Lauren S. Csaki, Laurent Vergnes, Jessica M. Lee, Jay Dewald, David N. Brindley, Elisa Atti, Sotirios Tetradis, Yuko Yoshinaga, Pieter J. De Jong, Loren G. Fong, Stephen G. Young, and Karen Reue

    PNAS September 11, 2012 109 (37) E2486-E2495; https://doi.org/10.1073/pnas.1205221109
  • Open Access

    Human blood metabolite timetable indicates internal body time

    Takeya Kasukawa, Masahiro Sugimoto, Akiko Hida, Yoichi Minami, Masayo Mori, Sato Honma, Ken-ichi Honma, Kazuo Mishima, Tomoyoshi Soga, and Hiroki R. Ueda

    PNAS September 11, 2012 109 (37) 15036-15041; https://doi.org/10.1073/pnas.1207768109
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    The nerve of ovulation-inducing factor in semen

    Marcelo H. Ratto, Yvonne A. Leduc, Ximena P. Valderrama, Karin E. van Straaten, Louis T. J. Delbaere, Roger A. Pierson, and Gregg P. Adams

    PNAS September 11, 2012 109 (37) 15042-15047; https://doi.org/10.1073/pnas.1206273109
  • Open Access

    Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin

    Nicolas Bonnet, Simon J. Conway, and Serge L. Ferrari

    PNAS September 11, 2012 109 (37) 15048-15053; https://doi.org/10.1073/pnas.1203085109

• Plant Biology

  • Open Access

    Photoperiodic regulation of the C-repeat binding factor (CBF) cold acclimation pathway and freezing tolerance in Arabidopsis thaliana

    Chin-Mei Lee and Michael F. Thomashow

    PNAS September 11, 2012 109 (37) 15054-15059; https://doi.org/10.1073/pnas.1211295109
  • Open Access

    Regulation of planar growth by the Arabidopsis AGC protein kinase UNICORN

    Balaji Enugutti, Charlotte Kirchhelle, Maxi Oelschner, Ramón Angel Torres Ruiz, Ivo Schliebner, Dario Leister, and Kay Schneitz

    PNAS September 11, 2012 109 (37) 15060-15065; https://doi.org/10.1073/pnas.1205089109

• Population Biology

  • Open Access

    High genetic load in an old isolated butterfly population

    Anniina L. K. Mattila, Anne Duplouy, Malla Kirjokangas, Rainer Lehtonen, Pasi Rastas, and Ilkka Hanski

    PNAS September 11, 2012 109 (37) E2496-E2505; https://doi.org/10.1073/pnas.1205789109
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    Unifying the spatial epidemiology and molecular evolution of emerging epidemics

    Oliver G. Pybus, Marc A. Suchard, Philippe Lemey, Flavien J. Bernardin, Andrew Rambaut, Forrest W. Crawford, Rebecca R. Gray, Nimalan Arinaminpathy, Susan L. Stramer, Michael P. Busch, and Eric L. Delwart

    PNAS September 11, 2012 109 (37) 15066-15071; https://doi.org/10.1073/pnas.1206598109