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Persistent cannabis users show neuropsychological decline from childhood to midlife

Madeline H. Meier, Avshalom Caspi, Antony Ambler, HonaLee Harrington, Renate Houts, Richard S. E. Keefe, Kay McDonald, Aimee Ward, Richie Poulton, and Terrie E. Moffitt
PNAS October 2, 2012 109 (40) 15980;
Madeline H. Meier
aDuke Transdisciplinary Prevention Research Center, Center for Child and Family Policy,
bDepartment of Psychology and Neuroscience, and
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  • For correspondence: madeline.meier@duke.edu
Avshalom Caspi
aDuke Transdisciplinary Prevention Research Center, Center for Child and Family Policy,
bDepartment of Psychology and Neuroscience, and
cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
eSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London SE5 8AF, United Kingdom; and
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Antony Ambler
eSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London SE5 8AF, United Kingdom; and
fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand
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HonaLee Harrington
bDepartment of Psychology and Neuroscience, and
cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
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Renate Houts
bDepartment of Psychology and Neuroscience, and
cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
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Richard S. E. Keefe
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
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Kay McDonald
fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand
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Aimee Ward
fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand
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Richie Poulton
fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand
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Terrie E. Moffitt
aDuke Transdisciplinary Prevention Research Center, Center for Child and Family Policy,
bDepartment of Psychology and Neuroscience, and
cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
eSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London SE5 8AF, United Kingdom; and
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This article has a Letter. Please see:

  • Personality may explain the association between cannabis use and neuropsychological impairment - March 04, 2013

See related content:

  • Causal inference and observational data
    - Mar 04, 2013
  • No SES or personality confound
    - Mar 04, 2013

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  • Impact of early onset and regular cannabis use
    - Sep 24, 2012
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Online Impact

 

Article Information

vol. 109 no. 40 15980

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue October 2, 2012.
  • Published first August 27, 2012.


Author Information

  1. Madeline H. Meiera,b,1,
  2. Avshalom Caspia,b,c,d,e,
  3. Antony Amblere,f,
  4. HonaLee Harringtonb,c,d,
  5. Renate Houtsb,c,d,
  6. Richard S. E. Keefed,
  7. Kay McDonaldf,
  8. Aimee Wardf,
  9. Richie Poultonf, and
  10. Terrie E. Moffitta,b,c,d,e
  1. aDuke Transdisciplinary Prevention Research Center, Center for Child and Family Policy,
  2. bDepartment of Psychology and Neuroscience, and
  3. cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
  4. dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
  5. eSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London SE5 8AF, United Kingdom; and
  6. fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand

Footnotes

  • ↵1To whom correspondence should be addressed. E-mail: madeline.meier{at}duke.edu.
  • Author contributions: M.H.M., A.C., and T.E.M. designed research; M.H.M., A.C., A.A., H.H., R.H., R.S.E.K., K.M., A.W., R.P., and T.E.M. performed research; M.H.M., A.C., R.H., and T.E.M. analyzed data; and M.H.M., A.C., and T.E.M. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • See Commentary on page 15970.

  • See full research article on page E2657 of www.pnas.org.

  • Cite this Author Summary as: PNAS 10.1073/pnas.1206820109.

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Total 20135058259128576
Jan 201447118471405
Feb 2014819814751055
Mar 20144642893841
Apr 201446991132941
May 20144492756681
Jun 20144186655701
Jul 201439254140818
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Sep 201447212486707
Oct 201467594448898
Nov 2014643833821152
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Total 2014677322504611813
Jan 201545801155460
Feb 20154619244011003
Mar 201552261695670
Apr 201551102256550
May 201540082682439
Jun 20153669952395
Jul 20153320838341
Aug 20154045977401
Sep 201536301227424
Oct 201550471736649
Nov 201553342028722
Dec 201547491474544
Total 201594910214216598
Jan 201681651892549
Feb 201653931777925
Mar 201647751653755
Apr 201650881911621
May 201669611974668
Jun 201650171646464
Jul 201631891325433
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Sep 2016381815301058
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Total 201685163201428467
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Feb 201733131991476
Mar 201738474050554
Apr 201740551345457
May 201729401120443
Jun 201724181067368
Jul 201725382265366
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Sep 201730231530496
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Total 201738401203015990
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Mar 201866693518721
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Jun 201845822543473
Jul 201831932360462
Aug 201830912210293
Sep 201829891774598
Oct 201816333046755
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Total 201844945323727966
Jan 201916901536492
Feb 201919801920533
Mar 201916042476621
Apr 201914352355485
May 201913393683436
Jun 2019152849126913
Jul 20197512362651
Aug 20199392232428
Sep 20198192582468
Oct 20198142868570
Nov 201973231171289
Dec 20198923001632
Total 2019145233304413518
Jan 20208022734830
Feb 20206662778633
Mar 20208072469643
Apr 20207402528668
May 20207382716475
Jun 20206012313403
Jul 20205002186461
Aug 20206382218399
Sep 20205762683514
Oct 20208203242927
Nov 20207523106494
Dec 20207052912344
Total 20208345318856791
Jan 20213011214228
Total 20213011214228
Total80685119322782517
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Cannabis use and neuropsychological decline
Madeline H. Meier, Avshalom Caspi, Antony Ambler, HonaLee Harrington, Renate Houts, Richard S. E. Keefe, Kay McDonald, Aimee Ward, Richie Poulton, Terrie E. Moffitt
Proceedings of the National Academy of Sciences Oct 2012, 109 (40) 15980;

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Cannabis use and neuropsychological decline
Madeline H. Meier, Avshalom Caspi, Antony Ambler, HonaLee Harrington, Renate Houts, Richard S. E. Keefe, Kay McDonald, Aimee Ward, Richie Poulton, Terrie E. Moffitt
Proceedings of the National Academy of Sciences Oct 2012, 109 (40) 15980;
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