Skip to main content
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Home
Home

Advanced Search

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses

New Research In

Physical Sciences

Featured Portals

  • Physics
  • Chemistry
  • Sustainability Science

Articles by Topic

  • Applied Mathematics
  • Applied Physical Sciences
  • Astronomy
  • Computer Sciences
  • Earth, Atmospheric, and Planetary Sciences
  • Engineering
  • Environmental Sciences
  • Mathematics
  • Statistics

Social Sciences

Featured Portals

  • Anthropology
  • Sustainability Science

Articles by Topic

  • Economic Sciences
  • Environmental Sciences
  • Political Sciences
  • Psychological and Cognitive Sciences
  • Social Sciences

Biological Sciences

Featured Portals

  • Sustainability Science

Articles by Topic

  • Agricultural Sciences
  • Anthropology
  • Applied Biological Sciences
  • Biochemistry
  • Biophysics and Computational Biology
  • Cell Biology
  • Developmental Biology
  • Ecology
  • Environmental Sciences
  • Evolution
  • Genetics
  • Immunology and Inflammation
  • Medical Sciences
  • Microbiology
  • Neuroscience
  • Pharmacology
  • Physiology
  • Plant Biology
  • Population Biology
  • Psychological and Cognitive Sciences
  • Sustainability Science
  • Systems Biology
PNAS Plus

Persistent cannabis users show neuropsychological decline from childhood to midlife

Madeline H. Meier, Avshalom Caspi, Antony Ambler, HonaLee Harrington, Renate Houts, Richard S. E. Keefe, Kay McDonald, Aimee Ward, Richie Poulton, and Terrie E. Moffitt
PNAS October 2, 2012 109 (40) 15980;
Madeline H. Meier
aDuke Transdisciplinary Prevention Research Center, Center for Child and Family Policy,
bDepartment of Psychology and Neuroscience, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: madeline.meier@duke.edu
Avshalom Caspi
aDuke Transdisciplinary Prevention Research Center, Center for Child and Family Policy,
bDepartment of Psychology and Neuroscience, and
cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
eSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London SE5 8AF, United Kingdom; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antony Ambler
eSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London SE5 8AF, United Kingdom; and
fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
HonaLee Harrington
bDepartment of Psychology and Neuroscience, and
cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Renate Houts
bDepartment of Psychology and Neuroscience, and
cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richard S. E. Keefe
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kay McDonald
fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aimee Ward
fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richie Poulton
fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Terrie E. Moffitt
aDuke Transdisciplinary Prevention Research Center, Center for Child and Family Policy,
bDepartment of Psychology and Neuroscience, and
cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
eSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London SE5 8AF, United Kingdom; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site

This article has a Letter. Please see:

  • Personality may explain the association between cannabis use and neuropsychological impairment - March 04, 2013

See related content:

  • Causal inference and observational data
    - Mar 04, 2013
  • No SES or personality confound
    - Mar 04, 2013

Related Articles

  • Impact of early onset and regular cannabis use
    - Sep 24, 2012
  • Article
  • Figures & SI
  • Info & Metrics
  • PDF
Loading

Article Figures & SI

Tables

    • View popup
    Table P1.

    IQ before and after cannabis use

    Persistence of regular cannabis useN% maleAge 7–13 y full-scale IQAge 38 y full-scale IQΔ IQ effect size*
    Never used24238.8499.84 (14.39)100.64 (15.25)0.05
    Used, never regularly50850.59102.27 (13.59)101.24 (14.81)−0.07
    Used regularly at 1 wave4772.34101.42 (14.41)98.45 (14.89)−0.20
    Used regularly at 2 waves3663.8995.28 (10.74)93.26 (11.44)−0.13
    Used regularly at 3+ waves4178.0596.00 (16.06)90.77 (13.88)−0.35
    • Means (SDs) are presented on child and adult full-scale IQ as a function of the number of study waves between ages 18 y and 38 y for which study members reported using cannabis on a regular basis (at least 4 d/wk). The last column shows that study members with more persistent cannabis use showed greater IQ decline from childhood to adulthood.

    • ↵*This coefficient indicates change in IQ from childhood to adulthood, with negative values indicating decreases in IQ. These change scores are in SD units, with values of 0.20, 0.50, and 0.80 reflecting small, medium, and large changes, respectively.

Data supplements

  • Supporting Information

    Files in this Data Supplement:

    • Download Supporting Information (PDF)
    • Download Table_S01 (DOCX)
    • Download Table_S02 (DOCX)
    • Download Table_S03 (DOCX)
PreviousNext
Back to top
Article Alerts
Email Article

Thank you for your interest in spreading the word on PNAS.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Persistent cannabis users show neuropsychological decline from childhood to midlife
(Your Name) has sent you a message from PNAS
(Your Name) thought you would like to see the PNAS web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Cannabis use and neuropsychological decline
Madeline H. Meier, Avshalom Caspi, Antony Ambler, HonaLee Harrington, Renate Houts, Richard S. E. Keefe, Kay McDonald, Aimee Ward, Richie Poulton, Terrie E. Moffitt
Proceedings of the National Academy of Sciences Oct 2012, 109 (40) 15980;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Cannabis use and neuropsychological decline
Madeline H. Meier, Avshalom Caspi, Antony Ambler, HonaLee Harrington, Renate Houts, Richard S. E. Keefe, Kay McDonald, Aimee Ward, Richie Poulton, Terrie E. Moffitt
Proceedings of the National Academy of Sciences Oct 2012, 109 (40) 15980;
Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Mendeley logo Mendeley
Proceedings of the National Academy of Sciences: 109 (40)
Table of Contents

Submit

Sign up for Article Alerts

Jump to section

  • Article
    • Author Summary
    • Footnotes
    • References
  • Figures & SI
  • Info & Metrics
  • PDF

You May Also be Interested in

Abstract depiction of a guitar and musical note
Science & Culture: At the nexus of music and medicine, some see disease treatments
Although the evidence is still limited, a growing body of research suggests music may have beneficial effects for diseases such as Parkinson’s.
Image credit: Shutterstock/agsandrew.
Scientist looking at an electronic tablet
Opinion: Standardizing gene product nomenclature—a call to action
Biomedical communities and journals need to standardize nomenclature of gene products to enhance accuracy in scientific and public communication.
Image credit: Shutterstock/greenbutterfly.
One red and one yellow modeled protein structures
Journal Club: Study reveals evolutionary origins of fold-switching protein
Shapeshifting designs could have wide-ranging pharmaceutical and biomedical applications in coming years.
Image credit: Acacia Dishman/Medical College of Wisconsin.
White and blue bird
Hazards of ozone pollution to birds
Amanda Rodewald, Ivan Rudik, and Catherine Kling talk about the hazards of ozone pollution to birds.
Listen
Past PodcastsSubscribe
Goats standing in a pin
Transplantation of sperm-producing stem cells
CRISPR-Cas9 gene editing can improve the effectiveness of spermatogonial stem cell transplantation in mice and livestock, a study finds.
Image credit: Jon M. Oatley.

Similar Articles

Site Logo
Powered by HighWire
  • Submit Manuscript
  • Twitter
  • Facebook
  • RSS Feeds
  • Email Alerts

Articles

  • Current Issue
  • Latest Articles
  • Archive

PNAS Portals

  • Anthropology
  • Chemistry
  • Classics
  • Front Matter
  • Physics
  • Sustainability Science
  • Teaching Resources

Information

  • Authors
  • Editorial Board
  • Reviewers
  • Librarians
  • Press
  • Site Map
  • PNAS Updates

Feedback    Privacy/Legal

Copyright © 2021 National Academy of Sciences. Online ISSN 1091-6490