Table of Contents

Biological Sciences

• Anthropology

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    Locomotor head movements and semicircular canal morphology in primates

    Michael D. Malinzak, Richard F. Kay, and Timothy E. Hullar

    PNAS October 30, 2012 109 (44) 17914-17919; https://doi.org/10.1073/pnas.1206139109

• Applied Biological Sciences

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    Peptide toxin glacontryphan-M is present in the wings of the butterfly Hebomoia glaucippe (Linnaeus, 1758) (Lepidoptera: Pieridae)

    Narkhyun Bae, Lin Li, Martin Lödl, and Gert Lubec

    PNAS October 30, 2012 109 (44) 17920-17924; https://doi.org/10.1073/pnas.1209632109
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    Controlled biosynthesis of odd-chain fuels and chemicals via engineered modular metabolic pathways

    Hsien-Chung Tseng and Kristala L. J. Prather

    PNAS October 30, 2012 109 (44) 17925-17930; https://doi.org/10.1073/pnas.1209002109

• Biochemistry

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    Apo-intermediate in the transport cycle of lactose permease (LacY)

    M. Gregor Madej, Sonya N. Soro, and H. Ronald Kaback

    PNAS October 30, 2012 109 (44) E2970-E2978; https://doi.org/10.1073/pnas.1211183109
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    Oxidized quinones signal onset of darkness directly to the cyanobacterial circadian oscillator

    • Inaugural Article

    Yong-Ick Kim, David J. Vinyard, Gennady M. Ananyev, G. Charles Dismukes, and Susan S. Golden

    PNAS October 30, 2012 109 (44) 17765-17769; https://doi.org/10.1073/pnas.1216401109
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    Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II

    Philip J. J. Robinson, David A. Bushnell, Michael J. Trnka, Alma L. Burlingame, and Roger D. Kornberg

    PNAS October 30, 2012 109 (44) 17931-17935; https://doi.org/10.1073/pnas.1215241109
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    N-terminal domain of vacuolar SNARE Vam7p promotes trans-SNARE complex assembly

    Hao Xu and William T. Wickner

    PNAS October 30, 2012 109 (44) 17936-17941; https://doi.org/10.1073/pnas.1216201109
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    Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

    Tom N. Grossmann, Johannes T.-H. Yeh, Brian R. Bowman, Qian Chu, Raymond E. Moellering, and Gregory L. Verdine

    PNAS October 30, 2012 109 (44) 17942-17947; https://doi.org/10.1073/pnas.1208396109
  • Open Access

    Neutralizing the function of a β-globin–associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain

    Joeva J. Barrow, Jude Masannat, and Jörg Bungert

    PNAS October 30, 2012 109 (44) 17948-17953; https://doi.org/10.1073/pnas.1207677109
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    Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1

    Na Yang, Weixiang Wang, Yan Wang, Mingzhu Wang, Qiang Zhao, Zihe Rao, Bing Zhu, and Rui-Ming Xu

    PNAS October 30, 2012 109 (44) 17954-17959; https://doi.org/10.1073/pnas.1208517109
  • Open Access

    Crystal structure of the human PRMT5:MEP50 complex

    Stephen Antonysamy, Zahid Bonday, Robert M. Campbell, Brandon Doyle, Zhanna Druzina, Tarun Gheyi, Bomie Han, Louis N. Jungheim, Yuewei Qian, Charles Rauch, Marijane Russell, J. Michael Sauder, Stephen R. Wasserman, Kenneth Weichert, Francis S. Willard, Aiping Zhang, and Spencer Emtage

    PNAS October 30, 2012 109 (44) 17960-17965; https://doi.org/10.1073/pnas.1209814109
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    Structural basis for multifunctional roles of mammalian aminopeptidase N

    Lang Chen, Yi-Lun Lin, Guiqing Peng, and Fang Li

    PNAS October 30, 2012 109 (44) 17966-17971; https://doi.org/10.1073/pnas.1210123109

• Biophysics and Computational Biology

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    Folding pathways of proteins with increasing degree of sequence identities but different structure and function

    Rajanish Giri, Angela Morrone, Carlo Travaglini-Allocatelli, Per Jemth, Maurizio Brunori, and Stefano Gianni

    PNAS October 30, 2012 109 (44) 17772-17776; https://doi.org/10.1073/pnas.1201794109
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    Transiently populated intermediate functions as a branching point of the FF domain folding pathway

    Dmitry M. Korzhnev, Tomasz L. Religa, and Lewis E. Kay

    PNAS October 30, 2012 109 (44) 17777-17782; https://doi.org/10.1073/pnas.1201799109
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    Energy landscape of knotted protein folding

    Joanna I. Sułkowska, Jeffrey K. Noel, and Jose N. Onuchic

    PNAS October 30, 2012 109 (44) 17783-17788; https://doi.org/10.1073/pnas.1201804109
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    Energy landscape and multiroute folding of topologically complex proteins adenylate kinase and 2ouf-knot

    Wenfei Li, Tsuyoshi Terakawa, Wei Wang, and Shoji Takada

    PNAS October 30, 2012 109 (44) 17789-17794; https://doi.org/10.1073/pnas.1201807109
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    Separating the effects of internal friction and transition state energy to explain the slow, frustrated folding of spectrin domains

    Beth G. Wensley, Lee Gyan Kwa, Sarah L. Shammas, Joseph M. Rogers, Stuart Browning, Ziqi Yang, and Jane Clarke

    PNAS October 30, 2012 109 (44) 17795-17799; https://doi.org/10.1073/pnas.1201793109
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    Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy

    Andrea Soranno, Brigitte Buchli, Daniel Nettels, Ryan R. Cheng, Sonja Müller-Späth, Shawn H. Pfeil, Armin Hoffmann, Everett A. Lipman, Dmitrii E. Makarov, and Benjamin Schuler

    PNAS October 30, 2012 109 (44) 17800-17806; https://doi.org/10.1073/pnas.1117368109
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    Simple few-state models reveal hidden complexity in protein folding

    Kyle A. Beauchamp, Robert McGibbon, Yu-Shan Lin, and Vijay S. Pande

    PNAS October 30, 2012 109 (44) 17807-17813; https://doi.org/10.1073/pnas.1201810109
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    Calcium-dependent folding of single calmodulin molecules

    Johannes Stigler and Matthias Rief

    PNAS October 30, 2012 109 (44) 17814-17819; https://doi.org/10.1073/pnas.1201801109
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    Direct observation of a force-induced switch in the anisotropic mechanical unfolding pathway of a protein

    Bharat Jagannathan, Phillip J. Elms, Carlos Bustamante, and Susan Marqusee

    PNAS October 30, 2012 109 (44) 17820-17825; https://doi.org/10.1073/pnas.1201800109
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    Counteracting chemical chaperone effects on the single-molecule α-synuclein structural landscape

    Allan Chris M. Ferreon, Mahdi Muhammad Moosa, Yann Gambin, and Ashok A. Deniz

    PNAS October 30, 2012 109 (44) 17826-17831; https://doi.org/10.1073/pnas.1201802109
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    Denaturant-dependent folding of GFP

    Govardhan Reddy, Zhenxing Liu, and D. Thirumalai

    PNAS October 30, 2012 109 (44) 17832-17838; https://doi.org/10.1073/pnas.1201808109
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    Nonnative interactions regulate folding and switching of myristoylated protein

    Dalit Shental-Bechor, Martin T.J. Smith, Duncan MacKenzie, Aron Broom, Amir Marcovitz, Fadila Ghashut, Chris Go, Fernando Bralha, Elizabeth M. Meiering, and Yaakov Levy

    PNAS October 30, 2012 109 (44) 17839-17844; https://doi.org/10.1073/pnas.1201803109
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    Protein folding kinetics and thermodynamics from atomistic simulation

    Stefano Piana, Kresten Lindorff-Larsen, and David E. Shaw

    PNAS October 30, 2012 109 (44) 17845-17850; https://doi.org/10.1073/pnas.1201811109
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    Multimolecule test-tube simulations of protein unfolding and aggregation

    Michelle E. McCully, David A. C. Beck, and Valerie Daggett

    PNAS October 30, 2012 109 (44) 17851-17856; https://doi.org/10.1073/pnas.1201809109
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    Regulation of the H4 tail binding and folding landscapes via Lys-16 acetylation

    Davit A. Potoyan and Garegin A. Papoian

    PNAS October 30, 2012 109 (44) 17857-17862; https://doi.org/10.1073/pnas.1201805109
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    Temperature dependence of protein folding kinetics in living cells

    Minghao Guo, Yangfan Xu, and Martin Gruebele

    PNAS October 30, 2012 109 (44) 17863-17867; https://doi.org/10.1073/pnas.1201797109
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    Fibrillation precursor of superoxide dismutase 1 revealed by gradual tuning of the protein-folding equilibrium

    Lisa Lang, Martin Kurnik, Jens Danielsson, and Mikael Oliveberg

    PNAS October 30, 2012 109 (44) 17868-17873; https://doi.org/10.1073/pnas.1201795109
  • Open Access

    Reverse engineering the euglenoid movement

    Marino Arroyo, Luca Heltai, Daniel Millán, and Antonio DeSimone

    PNAS October 30, 2012 109 (44) 17874-17879; https://doi.org/10.1073/pnas.1213977109
  • Open Access

    Effects of long DNA folding and small RNA stem–loop in thermophoresis

    Yusuke T. Maeda, Tsvi Tlusty, and Albert Libchaber

    PNAS October 30, 2012 109 (44) 17972-17977; https://doi.org/10.1073/pnas.1215764109
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    Energetic costs of cellular computation

    Pankaj Mehta and David J. Schwab

    PNAS October 30, 2012 109 (44) 17978-17982; https://doi.org/10.1073/pnas.1207814109

• Cell Biology

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    PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells

    Mary E. Hunzicker-Dunn, Blanca Lopez-Biladeau, Nathan C. Law, Sarah E. Fiedler, Daniel W. Carr, and Evelyn T. Maizels

    PNAS October 30, 2012 109 (44) E2979-E2988; https://doi.org/10.1073/pnas.1205661109
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    Plasticity of the asialoglycoprotein receptor deciphered by ensemble FRET imaging and single-molecule counting PALM imaging

    Malte Renz, Brian R. Daniels, György Vámosi, Irwin M. Arias, and Jennifer Lippincott-Schwartz

    PNAS October 30, 2012 109 (44) E2989-E2997; https://doi.org/10.1073/pnas.1211753109
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    Thin, a Trim32 ortholog, is essential for myofibril stability and is required for the integrity of the costamere in Drosophila

    Elisa M. LaBeau-DiMenna, Kathleen A. Clark, Kenneth D. Bauman, Daniel S. Parker, Richard M. Cripps, and Erika R. Geisbrecht

    PNAS October 30, 2012 109 (44) 17983-17988; https://doi.org/10.1073/pnas.1208408109

• Environmental Sciences

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    Role for urea in nitrification by polar marine Archaea

    Laura Alonso-Sáez, Alison S. Waller, Daniel R. Mende, Kevin Bakker, Hanna Farnelid, Patricia L. Yager, Connie Lovejoy, Jean-Éric Tremblay, Marianne Potvin, Friederike Heinrich, Marta Estrada, Lasse Riemann, Peer Bork, Carlos Pedrós-Alió, and Stefan Bertilsson

    PNAS October 30, 2012 109 (44) 17989-17994; https://doi.org/10.1073/pnas.1201914109
  • Open Access

    The 27–year decline of coral cover on the Great Barrier Reef and its causes

    • From the Cover

    Glenn De’ath, Katharina E. Fabricius, Hugh Sweatman, and Marji Puotinen

    PNAS October 30, 2012 109 (44) 17995-17999; https://doi.org/10.1073/pnas.1208909109
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    An original mode of symbiosis in open ocean plankton

    Johan Decelle, Ian Probert, Lucie Bittner, Yves Desdevises, Sébastien Colin, Colomban de Vargas, Martí Galí, Rafel Simó, and Fabrice Not

    PNAS October 30, 2012 109 (44) 18000-18005; https://doi.org/10.1073/pnas.1212303109

• Evolution

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    Comparative analyses of evolutionary rates reveal different pathways to encephalization in bats, carnivorans, and primates

    Jeroen B. Smaers, Dina K. N. Dechmann, Anjali Goswami, Christophe Soligo, and Kamran Safi

    PNAS October 30, 2012 109 (44) 18006-18011; https://doi.org/10.1073/pnas.1212181109
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    Recombination is associated with the evolution of genome structure and worker behavior in honey bees

    Clement F. Kent, Shermineh Minaei, Brock A. Harpur, and Amro Zayed

    PNAS October 30, 2012 109 (44) 18012-18017; https://doi.org/10.1073/pnas.1208094109

• Genetics

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    Extensive genetic variation in somatic human tissues

    Maeve O’Huallachain, Konrad J. Karczewski, Sherman M. Weissman, Alexander Eckehart Urban, and Michael P. Snyder

    PNAS October 30, 2012 109 (44) 18018-18023; https://doi.org/10.1073/pnas.1213736109
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    Punctuation and syntax of the RNA polymerase II CTD code in fission yeast

    Beate Schwer, Ana M. Sanchez, and Stewart Shuman

    PNAS October 30, 2012 109 (44) 18024-18029; https://doi.org/10.1073/pnas.1208995109

• Immunology

  • Open Access

    Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

    Gene Garrard Olinger Jr., James Pettitt, Do Kim, Cara Working, Ognian Bohorov, Barry Bratcher, Ernie Hiatt, Steven D. Hume, Ashley K. Johnson, Josh Morton, Michael Pauly, Kevin J. Whaley, Calli M. Lear, Julia E. Biggins, Corinne Scully, Lisa Hensley, and Larry Zeitlin

    PNAS October 30, 2012 109 (44) 18030-18035; https://doi.org/10.1073/pnas.1213709109
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    Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4⁺ and CD8⁺ T cells

    Judith N. Mandl, Rachel Liou, Frederick Klauschen, Nienke Vrisekoop, João P. Monteiro, Andrew J. Yates, Alex Y. Huang, and Ronald N. Germain

    PNAS October 30, 2012 109 (44) 18036-18041; https://doi.org/10.1073/pnas.1211717109

• Medical Sciences

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    Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells

    Hideto Koso, Haruna Takeda, Christopher Chin Kuan Yew, Jerrold M. Ward, Naoki Nariai, Kazuko Ueno, Masao Nagasaki, Sumiko Watanabe, Alistair G. Rust, David J. Adams, Neal G. Copeland, and Nancy A. Jenkins

    PNAS October 30, 2012 109 (44) E2998-E3007; https://doi.org/10.1073/pnas.1215899109
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    Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus

    Julia Freimuth, Frederic F. Clermont, Xiaozhu Huang, Angela DeSapio, Taku A. Tokuyasu, Dean Sheppard, and Rosemary J. Akhurst

    PNAS October 30, 2012 109 (44) 18042-18047; https://doi.org/10.1073/pnas.1205374109
  • Open Access

    Evidence of asymmetric cell division and centrosome inheritance in human neuroblastoma cells

    Hideki Izumi and Yasuhiko Kaneko

    PNAS October 30, 2012 109 (44) 18048-18053; https://doi.org/10.1073/pnas.1205525109
  • Open Access

    Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease

    Leelamma M. Panicker, Diana Miller, Tea Soon Park, Brijesh Patel, Judi L. Azevedo, Ola Awad, M. Athar Masood, Timothy D. Veenstra, Ehud Goldin, Barbara K. Stubblefield, Nahid Tayebi, Swamy K. Polumuri, Stefanie N. Vogel, Ellen Sidransky, Elias T. Zambidis, and Ricardo A. Feldman

    PNAS October 30, 2012 109 (44) 18054-18059; https://doi.org/10.1073/pnas.1207889109
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    Estrogen receptor prevents p53-dependent apoptosis in breast cancer

    Shannon T. Bailey, Hyunjin Shin, Thomas Westerling, Xiaole Shirley Liu, and Myles Brown

    PNAS October 30, 2012 109 (44) 18060-18065; https://doi.org/10.1073/pnas.1018858109
  • Open Access

    High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

    Elisa Mazzoni, Alfredo Corallini, Alfonso Cristaudo, Angelo Taronna, Gianfranco Tassi, Marco Manfrini, Manola Comar, Massimo Bovenzi, Roberto Guaschino, Francesca Vaniglia, Corrado Magnani, Ferruccio Casali, Giovanni Rezza, Giuseppe Barbanti-Brodano, Fernanda Martini, and Mauro G. Tognon

    PNAS October 30, 2012 109 (44) 18066-18071; https://doi.org/10.1073/pnas.1213238109
  • Open Access

    Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

    Fatih M. Uckun, Hong Ma, Jian Zhang, Zahide Ozer, Sinisa Dovat, Cheney Mao, Rita Ishkhanian, Patricia Goodman, and Sanjive Qazi

    PNAS October 30, 2012 109 (44) 18072-18077; https://doi.org/10.1073/pnas.1209828109

• Microbiology

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    Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

    Megan H. Orzalli, Neal A. DeLuca, and David M. Knipe

    PNAS October 30, 2012 109 (44) E3008-E3017; https://doi.org/10.1073/pnas.1211302109
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    Triggering the measles virus membrane fusion machinery

    Melinda A. Brindley, Makoto Takeda, Philippe Plattet, and Richard K. Plemper

    PNAS October 30, 2012 109 (44) E3018-E3027; https://doi.org/10.1073/pnas.1210925109
  • Open Access

    Provirophages and transpovirons as the diverse mobilome of giant viruses

    Christelle Desnues, Bernard La Scola, Natalya Yutin, Ghislain Fournous, Catherine Robert, Saïd Azza, Priscilla Jardot, Sonia Monteil, Angélique Campocasso, Eugene V. Koonin, and Didier Raoult

    PNAS October 30, 2012 109 (44) 18078-18083; https://doi.org/10.1073/pnas.1208835109
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    Link between intraphagosomal biotin and rapid phagosomal escape in Francisella

    Brooke A. Napier, Lena Meyer, James E. Bina, Mark A. Miller, Anders Sjöstedt, and David S. Weiss

    PNAS October 30, 2012 109 (44) 18084-18089; https://doi.org/10.1073/pnas.1206411109
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    Engineering robust control of two-component system phosphotransfer using modular scaffolds

    Weston R. Whitaker, Stephanie A. Davis, Adam P. Arkin, and John E. Dueber

    PNAS October 30, 2012 109 (44) 18090-18095; https://doi.org/10.1073/pnas.1209230109
  • Open Access

    BapE DNA endonuclease induces an apoptotic-like response to DNA damage in Caulobacter

    Julia Bos, Anastasiya A. Yakhnina, and Zemer Gitai

    PNAS October 30, 2012 109 (44) 18096-18101; https://doi.org/10.1073/pnas.1213332109

• Neuroscience

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    Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Na_v1.7)

    James R. Walker, Paul A. Novick, William H. Parsons, Malcolm McGregor, Jeff Zablocki, Vijay S. Pande, and J. Du Bois

    PNAS October 30, 2012 109 (44) 18102-18107; https://doi.org/10.1073/pnas.1206952109
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    Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates

    Andrew S. Fox, Jonathan A. Oler, Steven E. Shelton, Steven A. Nanda, Richard J. Davidson, Patrick H. Roseboom, and Ned H. Kalin

    PNAS October 30, 2012 109 (44) 18108-18113; https://doi.org/10.1073/pnas.1206723109
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    Mapping multisensory parietal face and body areas in humans

    Ruey-Song Huang, Ching-fu Chen, Alyssa T. Tran, Katie L. Holstein, and Martin I. Sereno

    PNAS October 30, 2012 109 (44) 18114-18119; https://doi.org/10.1073/pnas.1207946109
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    Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development

    Garret R. Anderson, Timothy Galfin, Wei Xu, Jason Aoto, Robert C. Malenka, and Thomas C. Südhof

    PNAS October 30, 2012 109 (44) 18120-18125; https://doi.org/10.1073/pnas.1216398109
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    Effects of dopamine depletion on LFP oscillations in striatum are task- and learning-dependent and selectively reversed by l-DOPA

    Nuné Lemaire, Ledia F. Hernandez, Dan Hu, Yasuo Kubota, Mark W. Howe, and Ann M. Graybiel

    PNAS October 30, 2012 109 (44) 18126-18131; https://doi.org/10.1073/pnas.1216403109
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    Acute selective ablation of rat insulin promoter-expressing (RIP_HER) neurons defines their orexigenic nature

    Eva Rother, Bengt F. Belgardt, Eva Tsaousidou, Brigitte Hampel, Ari Waisman, Martin G. Myers Jr., and Jens C. Brüning

    PNAS October 30, 2012 109 (44) 18132-18137; https://doi.org/10.1073/pnas.1206147109
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    Readily releasable pool of synaptic vesicles measured at single synaptic contacts

    Federico F. Trigo, Takeshi Sakaba, David Ogden, and Alain Marty

    PNAS October 30, 2012 109 (44) 18138-18143; https://doi.org/10.1073/pnas.1209798109
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    Oxytocin facilitates protective responses to aversive social stimuli in males

    Nadine Striepens, Dirk Scheele, Keith M. Kendrick, Benjamin Becker, Lea Schäfer, Knut Schwalba, Jürgen Reul, Wolfgang Maier, and René Hurlemann

    PNAS October 30, 2012 109 (44) 18144-18149; https://doi.org/10.1073/pnas.1208852109
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    Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells

    Nicholas H. Varvel, Stefan A. Grathwohl, Frank Baumann, Christian Liebig, Andrea Bosch, Bianca Brawek, Dietmar R. Thal, Israel F. Charo, Frank L. Heppner, Adriano Aguzzi, Olga Garaschuk, Richard M. Ransohoff, and Mathias Jucker

    PNAS October 30, 2012 109 (44) 18150-18155; https://doi.org/10.1073/pnas.1210150109
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    Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking

    Olivier George, Chelsea Sanders, John Freiling, Edward Grigoryan, Shayla Vu, Camryn D. Allen, Elena Crawford, Chitra D. Mandyam, and George F. Koob

    PNAS October 30, 2012 109 (44) 18156-18161; https://doi.org/10.1073/pnas.1116523109
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    Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia

    Xiaojing Ye, Andreea Marina, and Thomas J. Carew

    PNAS October 30, 2012 109 (44) 18162-18167; https://doi.org/10.1073/pnas.1209956109
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    Neural latencies across auditory cortex of macaque support a dorsal stream supramodal timing advantage in primates

    Corrie R. Camalier, William R. D’Angelo, Susanne J. Sterbing-D’Angelo, Lisa A. de la Mothe, and Troy A. Hackett

    PNAS October 30, 2012 109 (44) 18168-18173; https://doi.org/10.1073/pnas.1206387109

• Pharmacology

  • Open Access

    Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

    Radovan Spurny, Joachim Ramerstorfer, Kerry Price, Marijke Brams, Margot Ernst, Hugues Nury, Mark Verheij, Pierre Legrand, Daniel Bertrand, Sonia Bertrand, Dennis A. Dougherty, Iwan J. P. de Esch, Pierre-Jean Corringer, Werner Sieghart, Sarah C. R. Lummis, and Chris Ulens

    PNAS October 30, 2012 109 (44) E3028-E3034; https://doi.org/10.1073/pnas.1208208109
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    Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca²⁺ events, and IK_Ca channels, reducing arteriolar tone

    Pooneh Bagher, Timea Beleznai, Yasuo Kansui, Ray Mitchell, Christopher J. Garland, and Kim A. Dora

    PNAS October 30, 2012 109 (44) 18174-18179; https://doi.org/10.1073/pnas.1211946109

• Physiology

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    Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP

    Kamil Khafizov, Camilo Perez, Caroline Koshy, Matthias Quick, Klaus Fendler, Christine Ziegler, and Lucy R. Forrest

    PNAS October 30, 2012 109 (44) E3035-E3044; https://doi.org/10.1073/pnas.1209039109
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    Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance

    Xiaozhe Zhang, Jingjing Wang, Yue Feng, Jingpeng Ge, Wenfei Li, Wending Sun, Irene Iscla, Jie Yu, Paul Blount, Yang Li, and Maojun Yang

    PNAS October 30, 2012 109 (44) 18180-18185; https://doi.org/10.1073/pnas.1207977109
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    Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart

    Michael J. Cutler, Bradley N. Plummer, Xiaoping Wan, Qi-An Sun, Douglas Hess, Haiyan Liu, Isabelle Deschenes, David S. Rosenbaum, Jonathan S. Stamler, and Kenneth R. Laurita

    PNAS October 30, 2012 109 (44) 18186-18191; https://doi.org/10.1073/pnas.1210565109
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    Acidified seawater impacts sea urchin larvae pH regulatory systems relevant for calcification

    Meike Stumpp, Marian Y. Hu, Frank Melzner, Magdalena A. Gutowska, Narimane Dorey, Nina Himmerkus, Wiebke C. Holtmann, Sam T. Dupont, Michael C. Thorndyke, and Markus Bleich

    PNAS October 30, 2012 109 (44) 18192-18197; https://doi.org/10.1073/pnas.1209174109

• Plant Biology

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    Arabidopsis proline-rich protein important for development and abiotic stress tolerance is involved in microRNA biogenesis

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    From simple innate biases to complex visual concepts

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• Sustainability Science

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