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Research Article

Dynamic force sensing of filamin revealed in single-molecule experiments

Lorenz Rognoni, Johannes Stigler, Benjamin Pelz, Jari Ylänne, and Matthias Rief
PNAS November 27, 2012 109 (48) 19679-19684; https://doi.org/10.1073/pnas.1211274109
Lorenz Rognoni
aPhysik Department E22, Technische Universität München, 85748 Garching, Germany;
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Johannes Stigler
aPhysik Department E22, Technische Universität München, 85748 Garching, Germany;
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Benjamin Pelz
aPhysik Department E22, Technische Universität München, 85748 Garching, Germany;
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Jari Ylänne
bDepartment of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland; and
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Matthias Rief
aPhysik Department E22, Technische Universität München, 85748 Garching, Germany;
cMunich Center for Integrated Protein Science, 81377 München, Germany
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  • For correspondence: mrief@ph.tum.de
  1. Edited by James A. Spudich, Stanford University School of Medicine, Stanford, CA, and approved October 15, 2012 (received for review July 2, 2012)

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Article Information

vol. 109 no. 48 19679-19684
DOI: 
https://doi.org/10.1073/pnas.1211274109
PubMed: 
23150587

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue November 27, 2012.
  • Published first November 13, 2012.


Author Information

  1. Lorenz Rognonia,
  2. Johannes Stiglera,
  3. Benjamin Pelza,
  4. Jari Ylänneb, and
  5. Matthias Riefa,c,1
  1. aPhysik Department E22, Technische Universität München, 85748 Garching, Germany;
  2. bDepartment of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland; and
  3. cMunich Center for Integrated Protein Science, 81377 München, Germany
  1. Edited by James A. Spudich, Stanford University School of Medicine, Stanford, CA, and approved October 15, 2012 (received for review July 2, 2012)

Footnotes

  • ↵1To whom correspondence should be addressed. E-mail: mrief{at}ph.tum.de.
  • Author contributions: L.R. and M.R. designed research; L.R. performed research; J.S. and B.P. contributed new reagents/analytic tools; L.R., J.Y., and M.R. analyzed data; and L.R., J.Y., and M.R. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1211274109/-/DCSupplemental.

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Filamin is a dynamic cellular force sensor
Lorenz Rognoni, Johannes Stigler, Benjamin Pelz, Jari Ylänne, Matthias Rief
Proceedings of the National Academy of Sciences Nov 2012, 109 (48) 19679-19684; DOI: 10.1073/pnas.1211274109

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Filamin is a dynamic cellular force sensor
Lorenz Rognoni, Johannes Stigler, Benjamin Pelz, Jari Ylänne, Matthias Rief
Proceedings of the National Academy of Sciences Nov 2012, 109 (48) 19679-19684; DOI: 10.1073/pnas.1211274109
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Proceedings of the National Academy of Sciences: 109 (48)
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