Table of Contents

Biological Sciences

• Biochemistry

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    Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin

    Raquel Ruivo, Gian Carlo Bellenchi, Xiong Chen, Giovanni Zifarelli, Corinne Sagné, Cécile Debacker, Michael Pusch, Stéphane Supplisson, and Bruno Gasnier

    PNAS January 31, 2012 109 (5) E210-E217; https://doi.org/10.1073/pnas.1115581109
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    Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase

    • From the Cover

    Darragh Crotty, Gary Silkstone, Soumya Poddar, Richard Ranson, Adriele Prina-Mello, Michael T. Wilson, and J. M. D. Coey

    PNAS January 31, 2012 109 (5) 1437-1442; https://doi.org/10.1073/pnas.1117840108

    See companion article:

    • Are biochemical reactions affected by weak magnetic fields?

      - Jan 19, 2012
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    Efficient coupling of ATP hydrolysis to translocation by RecQ helicase

    Behzad Rad and Stephen C. Kowalczykowski

    PNAS January 31, 2012 109 (5) 1443-1448; https://doi.org/10.1073/pnas.1119952109
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    Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P₄-ATPase ATP8A2

    Jonathan A. Coleman, Anna L. Vestergaard, Robert S. Molday, Bente Vilsen, and Jens Peter Andersen

    PNAS January 31, 2012 109 (5) 1449-1454; https://doi.org/10.1073/pnas.1108862109
  • Open Access

    Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation

    Xuan Cao, Courtney Voss, Bing Zhao, Tomonori Kaneko, and Shawn Shun-Cheng Li

    PNAS January 31, 2012 109 (5) 1455-1460; https://doi.org/10.1073/pnas.1114368109
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    Protein-binding dynamics imaged in a living cell

    Yael Phillip, Vladimir Kiss, and Gideon Schreiber

    PNAS January 31, 2012 109 (5) 1461-1466; https://doi.org/10.1073/pnas.1112171109

• Biophysics and Computational Biology

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    Full-length myosin Va exhibits altered gating during processive movement on actin

    Jessica M. Armstrong, Elena Krementsova, Arthur J. Michalek, Aoife T. Heaslip, Shane R. Nelson, Kathleen M. Trybus, and David M. Warshaw

    PNAS January 31, 2012 109 (5) E218-E224; https://doi.org/10.1073/pnas.1109709109
  • Open Access

    Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach

    • Inaugural Article

    Keren Lasker, Friedrich Förster, Stefan Bohn, Thomas Walzthoeni, Elizabeth Villa, Pia Unverdorben, Florian Beck, Ruedi Aebersold, Andrej Sali, and Wolfgang Baumeister

    PNAS January 31, 2012 109 (5) 1380-1387; https://doi.org/10.1073/pnas.1120559109
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    Sampling protein motion and solvent effect during ligand binding

    Vittorio Limongelli, Luciana Marinelli, Sandro Cosconati, Concettina La Motta, Stefania Sartini, Laura Mugnaini, Federico Da Settimo, Ettore Novellino, and Michele Parrinello

    PNAS January 31, 2012 109 (5) 1467-1472; https://doi.org/10.1073/pnas.1112181108
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    Tracking energy transfer between light harvesting complex 2 and 1 in photosynthetic membranes grown under high and low illumination

    Larry Lüer, Vladimíra Moulisová, Sarah Henry, Dario Polli, Tatas H. P. Brotosudarmo, Sajjad Hoseinkhani, Daniele Brida, Guglielmo Lanzani, Giulio Cerullo, and Richard J. Cogdell

    PNAS January 31, 2012 109 (5) 1473-1478; https://doi.org/10.1073/pnas.1113080109
  • Open Access

    Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy

    Eri Sakata, Stefan Bohn, Oana Mihalache, Petra Kiss, Florian Beck, Istvan Nagy, Stephan Nickell, Keiji Tanaka, Yasushi Saeki, Friedrich Förster, and Wolfgang Baumeister

    PNAS January 31, 2012 109 (5) 1479-1484; https://doi.org/10.1073/pnas.1119394109
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    Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer

    Peter C. Anthony, Christian F. Perez, Cuauhtémoc García-García, and Steven M. Block

    PNAS January 31, 2012 109 (5) 1485-1489; https://doi.org/10.1073/pnas.1115045109
  • Open Access

    β-Bulge triggers route-switching on the functional landscape of interleukin-1β

    Dominique T. Capraro, Melinda Roy, José N. Onuchic, Shachi Gosavi, and Patricia A. Jennings

    PNAS January 31, 2012 109 (5) 1490-1493; https://doi.org/10.1073/pnas.1114430109
  • Open Access

    Automated selection of stabilizing mutations in designed and natural proteins

    Benjamin Borgo and James J. Havranek

    PNAS January 31, 2012 109 (5) 1494-1499; https://doi.org/10.1073/pnas.1115172109
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    Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment

    Seamus Morrone, Zhihong Cheng, Randall T. Moon, Feng Cong, and Wenqing Xu

    PNAS January 31, 2012 109 (5) 1500-1505; https://doi.org/10.1073/pnas.1116618109

• Cell Biology

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    Spatial organization of the extracellular matrix regulates cell–cell junction positioning

    Qingzong Tseng, Eve Duchemin-Pelletier, Alexandre Deshiere, Martial Balland, Hervé Guillou, Odile Filhol, and Manuel Théry

    PNAS January 31, 2012 109 (5) 1506-1511; https://doi.org/10.1073/pnas.1106377109
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    Soluble factors produced by activated CD4⁺ T cells modulate EBV latency

    Noémi Nagy, Mónika Ádori, Abu Rasul, Frank Heuts, Daniel Salamon, Dorina Ujvári, Harsha S. Madapura, Benjamin Leveau, George Klein, and Eva Klein

    PNAS January 31, 2012 109 (5) 1512-1517; https://doi.org/10.1073/pnas.1120587109
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    Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state

    Philipp Mergenthaler, Anja Kahl, Anne Kamitz, Vincent van Laak, Katharina Stohlmann, Susanne Thomsen, Heiko Klawitter, Ingo Przesdzing, Lars Neeb, Dorette Freyer, Josef Priller, Tony J. Collins, Dirk Megow, Ulrich Dirnagl, David W. Andrews, and Andreas Meisel

    PNAS January 31, 2012 109 (5) 1518-1523; https://doi.org/10.1073/pnas.1108225109
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    Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription

    Wensheng Deng, Cesar Lopez-Camacho, Jen-Yang Tang, Daniel Mendoza-Villanueva, Apolinar Maya-Mendoza, Dean A. Jackson, and Paul Shore

    PNAS January 31, 2012 109 (5) 1524-1529; https://doi.org/10.1073/pnas.1107879109
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    Brush border Myosin Ia has tumor suppressor activity in the intestine

    Rocco Mazzolini, Higinio Dopeso, Silvia Mateo-Lozano, Wakam Chang, Paulo Rodrigues, Sarah Bazzocco, Hafid Alazzouzi, Stefania Landolfi, Javier Hernández-Losa, Elena Andretta, Pia Alhopuro, Eloy Espín, Manel Armengol, Josep Tabernero, Santiago Ramón y Cajal, Matthias Kloor, Johannes Gebert, John M. Mariadason, Simo Schwartz Jr., Lauri A. Aaltonen, Mark S. Mooseker, and Diego Arango

    PNAS January 31, 2012 109 (5) 1530-1535; https://doi.org/10.1073/pnas.1108411109
  • Open Access

    Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2

    Brad J. Niles, Huzefa Mogri, Andrew Hill, Ariadne Vlahakis, and Ted Powers

    PNAS January 31, 2012 109 (5) 1536-1541; https://doi.org/10.1073/pnas.1117563109
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    Nematode sperm maturation triggered by protease involves sperm-secreted serine protease inhibitor (Serpin)

    Yanmei Zhao, Wei Sun, Pan Zhang, Hao Chi, Mei-Jun Zhang, Chun-Qing Song, Xuan Ma, Yunlong Shang, Bin Wang, Youqiao Hu, Zhiqi Hao, Andreas F. Hühmer, Fanxia Meng, Steven W. L'Hernault, Si-Min He, Meng-Qiu Dong, and Long Miao

    PNAS January 31, 2012 109 (5) 1542-1547; https://doi.org/10.1073/pnas.1109912109

• Developmental Biology

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    The channel kinase, TRPM7, is required for early embryonic development

    Jie Jin, Long-Jun Wu, Janice Jun, Xiping Cheng, Haoxing Xu, Nancy C. Andrews, and David E. Clapham

    PNAS January 31, 2012 109 (5) E225-E233; https://doi.org/10.1073/pnas.1120033109
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    Synthetic in vivo validation of gene network circuitry

    Sagar S. Damle and Eric H. Davidson

    PNAS January 31, 2012 109 (5) 1548-1553; https://doi.org/10.1073/pnas.1119905109
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    Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis

    Wim Grunewald, Ive De Smet, Daniel R. Lewis, Christian Löfke, Leentje Jansen, Geert Goeminne, Robin Vanden Bossche, Mansour Karimi, Bert De Rybel, Bartel Vanholme, Thomas Teichmann, Wout Boerjan, Marc C. E. Van Montagu, Godelieve Gheysen, Gloria K. Muday, Jiří Friml, and Tom Beeckman

    PNAS January 31, 2012 109 (5) 1554-1559; https://doi.org/10.1073/pnas.1121134109
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    Characterization of MADS-domain transcription factor complexes in Arabidopsis flower development

    Cezary Smaczniak, Richard G. H. Immink, Jose M. Muiño, Robert Blanvillain, Marco Busscher, Jacqueline Busscher-Lange, Q. D. (Peter) Dinh, Shujing Liu, Adrie H. Westphal, Sjef Boeren, François Parcy, Lin Xu, Cristel C. Carles, Gerco C. Angenent, and Kerstin Kaufmann

    PNAS January 31, 2012 109 (5) 1560-1565; https://doi.org/10.1073/pnas.1112871109
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    BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord

    Qian Ding, Pushkar S. Joshi, Zheng-hua Xie, Mengqing Xiang, and Lin Gan

    PNAS January 31, 2012 109 (5) 1566-1571; https://doi.org/10.1073/pnas.1112392109
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    Transcriptional interpretation of the EGF receptor signaling gradient

    Alisa Fuchs, Lily S. Cheung, Enrica Charbonnier, Stanislav Y. Shvartsman, and George Pyrowolakis

    PNAS January 31, 2012 109 (5) 1572-1577; https://doi.org/10.1073/pnas.1115190109
  • Open Access

    Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system

    Jessica Plavicki, Sara Mader, Eric Pueschel, Patrick Peebles, and Grace Boekhoff-Falk

    PNAS January 31, 2012 109 (5) 1578-1583; https://doi.org/10.1073/pnas.1016741109

• Evolution

  • Open Access

    Evolution of patterns on Conus shells

    Zhenqiang Gong, Nichilos J. Matzke, Bard Ermentrout, Dawn Song, Jann E. Vendetti, Montgomery Slatkin, and George Oster

    PNAS January 31, 2012 109 (5) E234-E241; https://doi.org/10.1073/pnas.1119859109
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    Carnivorous dinocephalian from the Middle Permian of Brazil and tetrapod dispersal in Pangaea

    Juan Carlos Cisneros, Fernando Abdala, Saniye Atayman-Güven, Bruce S. Rubidge, A. M. Celâl Şengör, and Cesar L. Schultz

    PNAS January 31, 2012 109 (5) 1584-1588; https://doi.org/10.1073/pnas.1115975109
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    Exceptionally preserved crustaceans from western Canada reveal a cryptic Cambrian radiation

    Thomas H. P. Harvey, Maria I. Vélez, and Nicholas J. Butterfield

    PNAS January 31, 2012 109 (5) 1589-1594; https://doi.org/10.1073/pnas.1115244109
  • Open Access

    Experimental evolution of multicellularity

    William C. Ratcliff, R. Ford Denison, Mark Borrello, and Michael Travisano

    PNAS January 31, 2012 109 (5) 1595-1600; https://doi.org/10.1073/pnas.1115323109
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    Evolution of CpG island promoter function underlies changes in KChIP2 potassium channel subunit gene expression in mammalian heart

    Qinghong Yan, Rajeev Masson, Yi Ren, Barbara Rosati, and David McKinnon

    PNAS January 31, 2012 109 (5) 1601-1606; https://doi.org/10.1073/pnas.1114516109

• Immunology

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    Polyfunctional responses by human T cells result from sequential release of cytokines

    • From the Cover

    Qing Han, Neda Bagheri, Elizabeth M. Bradshaw, David A. Hafler, Douglas A. Lauffenburger, and J. Christopher Love

    PNAS January 31, 2012 109 (5) 1607-1612; https://doi.org/10.1073/pnas.1117194109

    See companion article:

    • Travels in time: Assessing the functional complexity of T cells

      - Jan 20, 2012
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    Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81

    Yael Sagi, Angela Landrigan, Ronald Levy, and Shoshana Levy

    PNAS January 31, 2012 109 (5) 1613-1618; https://doi.org/10.1073/pnas.1121307109
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    Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing

    Delphyne Descamps, Mathieu Le Gars, Viviane Balloy, Diane Barbier, Sophia Maschalidi, Mira Tohme, Michel Chignard, Reuben Ramphal, Bénédicte Manoury, and Jean-Michel Sallenave

    PNAS January 31, 2012 109 (5) 1619-1624; https://doi.org/10.1073/pnas.1108464109
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    Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function

    Alexandra Zanin-Zhorov, Jiqiang Lin, Jose Scher, Sudha Kumari, David Blair, Keli L. Hippen, Bruce R. Blazar, Steven B. Abramson, Juan J. Lafaille, and Michael L. Dustin

    PNAS January 31, 2012 109 (5) 1625-1630; https://doi.org/10.1073/pnas.1110120109
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    Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance

    Maria Papatriantafyllou, Gerhard Moldenhauer, Julia Ludwig, Anna Tafuri, Natalio Garbi, Gorana Hollmann, Günter Küblbeck, Alexandra Klevenz, Sabine Schmitt, Georg Pougialis, Christof Niehrs, Hermann-Josef Gröne, Gunter J. Hämmerling, Bernd Arnold, and Thilo Oelert

    PNAS January 31, 2012 109 (5) 1631-1636; https://doi.org/10.1073/pnas.1115980109

• Medical Sciences

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    Glycogen synthase kinase 3β transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K⁺ channels

    Dennis Rottlaender, Kerstin Boengler, Martin Wolny, Astrid Schwaiger, Lukas J. Motloch, Michel Ovize, Rainer Schulz, Gerd Heusch, and Uta C. Hoppe

    PNAS January 31, 2012 109 (5) E242-E251; https://doi.org/10.1073/pnas.1107479109
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    Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer

    A. Hunter Shain, Craig P. Giacomini, Karen Matsukuma, Collins A. Karikari, Murali D. Bashyam, Manuel Hidalgo, Anirban Maitra, and Jonathan R. Pollack

    PNAS January 31, 2012 109 (5) E252-E259; https://doi.org/10.1073/pnas.1114817109
  • Open Access

    Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment

    Liliana Guzman-Rojas, Roberto Rangel, Ahmad Salameh, Julianna K. Edwards, Eleonora Dondossola, Yun-Gon Kim, Alan Saghatelian, Ricardo J. Giordano, Mikhail G. Kolonin, Fernanda I. Staquicini, Erkki Koivunen, Richard L. Sidman, Wadih Arap, and Renata Pasqualini

    PNAS January 31, 2012 109 (5) 1637-1642; https://doi.org/10.1073/pnas.1120790109
  • Open Access

    Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression

    Justin M. Drake, Nicholas A. Graham, Tanya Stoyanova, Amir Sedghi, Andrew S. Goldstein, Houjian Cai, Daniel A. Smith, Hong Zhang, Evangelia Komisopoulou, Jiaoti Huang, Thomas G. Graeber, and Owen N. Witte

    PNAS January 31, 2012 109 (5) 1643-1648; https://doi.org/10.1073/pnas.1120985109
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    Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice

    Viviana Moresi, Michele Carrer, Chad E. Grueter, Oktay F. Rifki, John M. Shelton, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson

    PNAS January 31, 2012 109 (5) 1649-1654; https://doi.org/10.1073/pnas.1121159109
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    Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases

    Ferenc G. Rick, Andrew V. Schally, Luca Szalontay, Norman L. Block, Karoly Szepeshazi, Mehrdad Nadji, Marta Zarandi, Florian Hohla, Stefan Buchholz, and Stephan Seitz

    PNAS January 31, 2012 109 (5) 1655-1660; https://doi.org/10.1073/pnas.1120588109
  • Open Access

    Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)

    Martine Girard, Roxanne Larivière, David A. Parfitt, Emily C. Deane, Rebecca Gaudet, Nadya Nossova, Francois Blondeau, George Prenosil, Esmeralda G. M. Vermeulen, Michael R. Duchen, Andrea Richter, Eric A. Shoubridge, Kalle Gehring, R. Anne McKinney, Bernard Brais, J. Paul Chapple, and Peter S. McPherson

    PNAS January 31, 2012 109 (5) 1661-1666; https://doi.org/10.1073/pnas.1113166109
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    Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

    Chongben Zhang, Angela A. Wendel, Matthew R. Keogh, Thurl E. Harris, Jie Chen, and Rosalind A. Coleman

    PNAS January 31, 2012 109 (5) 1667-1672; https://doi.org/10.1073/pnas.1110730109
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    IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

    Emma Lefrançais, Stephane Roga, Violette Gautier, Anne Gonzalez-de-Peredo, Bernard Monsarrat, Jean-Philippe Girard, and Corinne Cayrol

    PNAS January 31, 2012 109 (5) 1673-1678; https://doi.org/10.1073/pnas.1115884109
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    Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)–induced proliferation, migration, and neovascularization of ischemic muscle

    Eugene Jang, Hassan Albadawi, Michael T. Watkins, Elazer R. Edelman, and Aaron B. Baker

    PNAS January 31, 2012 109 (5) 1679-1684; https://doi.org/10.1073/pnas.1117885109
  • Open Access

    Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity

    Amanda M. Goh, Chin Yan Lim, Poh Cheang Chiam, Ling Li, Michael B. Mann, Karen M. Mann, Sergio Menendez, and David P. Lane

    PNAS January 31, 2012 109 (5) 1685-1690; https://doi.org/10.1073/pnas.1114173109

• Microbiology

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    Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses

    Elizabeth A. White, Mathew E. Sowa, Min Jie Alvin Tan, Sheila Jeudy, Sebastian D. Hayes, Sreevidya Santha, Karl Münger, J. Wade Harper, and Peter M. Howley

    PNAS January 31, 2012 109 (5) E260-E267; https://doi.org/10.1073/pnas.1116776109
  • Open Access

    In-feed antibiotic effects on the swine intestinal microbiome

    • From the Cover

    Torey Looft, Timothy A. Johnson, Heather K. Allen, Darrell O. Bayles, David P. Alt, Robert D. Stedtfeld, Woo Jun Sul, Tiffany M. Stedtfeld, Benli Chai, James R. Cole, Syed A. Hashsham, James M. Tiedje, and Thad B. Stanton

    PNAS January 31, 2012 109 (5) 1691-1696; https://doi.org/10.1073/pnas.1120238109
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    Polar growth in the Alphaproteobacterial order Rhizobiales

    Pamela J. B. Brown, Miguel A. de Pedro, David T. Kysela, Charles Van der Henst, Jinwoo Kim, Xavier De Bolle, Clay Fuqua, and Yves V. Brun

    PNAS January 31, 2012 109 (5) 1697-1701; https://doi.org/10.1073/pnas.1114476109
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    Surface multiheme c-type cytochromes from Thermincola potens and implications for respiratory metal reduction by Gram-positive bacteria

    Hans K. Carlson, Anthony T. Iavarone, Amita Gorur, Boon Siang Yeo, Rosalie Tran, Ryan A. Melnyk, Richard A. Mathies, Manfred Auer, and John D. Coates

    PNAS January 31, 2012 109 (5) 1702-1707; https://doi.org/10.1073/pnas.1112905109

• Neuroscience

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    Distinct energy metabolism of auditory and vestibular sensory epithelia revealed by quantitative mass spectrometry using MS2 intensity

    Kateri J. Spinelli, John E. Klimek, Phillip A. Wilmarth, Jung-Bum Shin, Dongseok Choi, Larry L. David, and Peter G. Gillespie

    PNAS January 31, 2012 109 (5) E268-E277; https://doi.org/10.1073/pnas.1115866109
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    GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis

    Tiffany A. Wills, Jason R. Klug, Yuval Silberman, Anthony J. Baucum, Carl Weitlauf, Roger J. Colbran, Eric Delpire, and Danny G. Winder

    PNAS January 31, 2012 109 (5) E278-E287; https://doi.org/10.1073/pnas.1113820109
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    Functional profiling of neurons through cellular neuropharmacology

    • Inaugural Article

    Russell W. Teichert, Nathan J. Smith, Shrinivasan Raghuraman, Doju Yoshikami, Alan R. Light, and Baldomero M. Olivera

    PNAS January 31, 2012 109 (5) 1388-1395; https://doi.org/10.1073/pnas.1118833109

    See companion article:

    • QnAs with Baldomero M. Olivera

      - Jul 30, 2012
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    Dissociable neural representations of reinforcement and belief prediction errors underlie strategic learning

    Lusha Zhu, Kyle E. Mathewson, and Ming Hsu

    PNAS January 31, 2012 109 (5) 1419-1424; https://doi.org/10.1073/pnas.1116783109
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    Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor β ligand

    Xin-jie Tan, Yu-bing Dai, Wan-fu Wu, Hyun-Jin Kim, Rodrigo P. A. Barros, Timothy I. Richardson, Benjamin C. Yaden, Margaret Warner, David L. McKinzie, Venkatesh Krishnan, and Jan-Åke Gustafsson

    PNAS January 31, 2012 109 (5) 1708-1712; https://doi.org/10.1073/pnas.1121162109
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    3β-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders

    Massimiliano Bianchi and Etienne-Emile Baulieu

    PNAS January 31, 2012 109 (5) 1713-1718; https://doi.org/10.1073/pnas.1121485109
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    Striatum processes reward differently in adolescents versus adults

    David A. Sturman and Bita Moghaddam

    PNAS January 31, 2012 109 (5) 1719-1724; https://doi.org/10.1073/pnas.1114137109
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    Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches

    Yasuko Noda, Shinsuke Niwa, Noriko Homma, Hiroyuki Fukuda, Shinobu Imajo-Ohmi, and Nobutaka Hirokawa

    PNAS January 31, 2012 109 (5) 1725-1730; https://doi.org/10.1073/pnas.1107808109
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    Spatiotemporal dynamics of neocortical excitation and inhibition during human sleep

    Adrien Peyrache, Nima Dehghani, Emad N. Eskandar, Joseph R. Madsen, William S. Anderson, Jacob A. Donoghue, Leigh R. Hochberg, Eric Halgren, Sydney S. Cash, and Alain Destexhe

    PNAS January 31, 2012 109 (5) 1731-1736; https://doi.org/10.1073/pnas.1109895109
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    Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-d-aspartate receptors

    Haitao You, Shigeki Tsutsui, Shahid Hameed, Thomas J. Kannanayakal, Lina Chen, Peng Xia, Jordan D. T. Engbers, Stuart A. Lipton, Peter K. Stys, and Gerald W. Zamponi

    PNAS January 31, 2012 109 (5) 1737-1742; https://doi.org/10.1073/pnas.1110789109

• Physiology

  • Open Access

    Telomere length in early life predicts lifespan

    Britt J. Heidinger, Jonathan D. Blount, Winnie Boner, Kate Griffiths, Neil B. Metcalfe, and Pat Monaghan

    PNAS January 31, 2012 109 (5) 1743-1748; https://doi.org/10.1073/pnas.1113306109
  • Open Access

    Ca²⁺ signaling amplification by oligomerization of L-type Ca_v1.2 channels

    Rose E. Dixon, Can Yuan, Edward P. Cheng, Manuel F. Navedo, and Luis F. Santana

    PNAS January 31, 2012 109 (5) 1749-1754; https://doi.org/10.1073/pnas.1116731109

• Plant Biology

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    Preceramic maize from Paredones and Huaca Prieta, Peru

    Alexander Grobman, Duccio Bonavia, Tom D. Dillehay, Dolores R. Piperno, José Iriarte, and Irene Holst

    PNAS January 31, 2012 109 (5) 1755-1759; https://doi.org/10.1073/pnas.1120270109
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    CLE-like (CLEL) peptides control the pattern of root growth and lateral root development in Arabidopsis

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    PNAS January 31, 2012 109 (5) 1760-1765; https://doi.org/10.1073/pnas.1119864109
  • Open Access

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  • Open Access

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    • From the Cover

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    PNAS January 31, 2012 109 (5) 1772-1777; https://doi.org/10.1073/pnas.1120992109
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    Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis

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    PNAS January 31, 2012 109 (5) 1778-1783; https://doi.org/10.1073/pnas.1112500109
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    Qa-SNAREs localized to the trans-Golgi network regulate multiple transport pathways and extracellular disease resistance in plants

    Tomohiro Uemura, Hyeran Kim, Chieko Saito, Kazuo Ebine, Takashi Ueda, Paul Schulze-Lefert, and Akihiko Nakano

    PNAS January 31, 2012 109 (5) 1784-1789; https://doi.org/10.1073/pnas.1115146109
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    MicroRNA regulation of plant innate immune receptors

    Feng Li, Daniela Pignatta, Claire Bendix, Jacob O. Brunkard, Megan M. Cohn, Jeffery Tung, Haoyu Sun, Pavan Kumar, and Barbara Baker

    PNAS January 31, 2012 109 (5) 1790-1795; https://doi.org/10.1073/pnas.1118282109

• Psychological and Cognitive Sciences

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    Retinotopic memory is more precise than spatiotopic memory

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    PNAS January 31, 2012 109 (5) 1796-1801; https://doi.org/10.1073/pnas.1113168109

• Systems Biology

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    Noninvasive inference of the molecular chemotactic response using bacterial trajectories

    Jean-Baptiste Masson, Guillaume Voisinne, Jerome Wong-Ng, Antonio Celani, and Massimo Vergassola

    PNAS January 31, 2012 109 (5) 1802-1807; https://doi.org/10.1073/pnas.1116772109