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Table of Contents
February 21, 2012; vol. 109 no. 8
This Week in PNAS
Letters (Online Only)
- You have accessReply to Karapetyan: Viral synthesis and assembly is unlikely to occur under cell-free PMCA conditionsBruce Chesebro, Mikael Klingeborn, and Brent Race
QnAs
Profile
PNAS Plus (Author Summaries and Research Articles)
Physical Sciences – Chemistry – Biological Sciences – Ecology
- Open AccessUnusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpeckerDorit Eliyahu, Satoshi Nojima, Richard G. Santangelo, Shannon Carpenter, Francis X. Webster, David J. Kiemle, Cesar Gemeno, Walter S. Leal, and Coby Schal
Social Sciences – Anthropology
- You have accessHeterogeneity of hunting ability and nutritional status among domestic dogs in lowland NicaraguaJeremy M. Koster and Kenneth B. Tankersley
Biological Sciences – Cell Biology
- You have accessRabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosisDeanna M. Navaroli, Karl D. Bellvé, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera
Biological Sciences – Developmental Biology
- You have accessCompensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte developmentPengpeng Ma, Hua Pan, Rusty L. Montgomery, Eric N. Olson, and Richard M. Schultz
Biological Sciences – Microbiology
- Open AccessMevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatusSabiha Yasmin, Laura Alcazar-Fuoli, Mario Gründlinger, Thomas Puempel, Timothy Cairns, Michael Blatzer, Jordi F. Lopez, Joan O. Grimalt, Elaine Bignell, and Hubertus Haas
Biological Sciences – Neuroscience
- You have accessPhoneme and word recognition in the auditory ventral streamIain DeWitt and Josef P. Rauschecker
- Open AccessReduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapsesXuelin Lou, Fan Fan, Mirko Messa, Andrea Raimondi, Yumei Wu, Loren L. Looger, Shawn M. Ferguson, and Pietro De Camilli
Biological Sciences – Physiology
- You have accessSweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretionGeorge A. Kyriazis, Mangala M. Soundarapandian, and Björn Tyrberg
Breast Cancer Special Feature (free online)
Introduction
Research Articles
- You have accessFeedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitorsAnindita Chakrabarty, Violeta Sánchez, María G. Kuba, Cammie Rinehart, and Carlos L. Arteaga
- You have accessSubtype and pathway specific responses to anticancer compounds in breast cancerLaura M. Heiser, Anguraj Sadanandam, Wen-Lin Kuo, Stephen C. Benz, Theodore C. Goldstein, Sam Ng, William J. Gibb, Nicholas J. Wang, Safiyyah Ziyad, Frances Tong, Nora Bayani, Zhi Hu, Jessica I. Billig, Andrea Dueregger, Sophia Lewis, Lakshmi Jakkula, James E. Korkola, Steffen Durinck, François Pepin, Yinghui Guan, Elizabeth Purdom, Pierre Neuvial, Henrik Bengtsson, Kenneth W. Wood, Peter G. Smith, Lyubomir T. Vassilev, Bryan T. Hennessy, Joel Greshock, Kurtis E. Bachman, Mary Ann Hardwicke, John W. Park, Laurence J. Marton, Denise M. Wolf, Eric A. Collisson, Richard M. Neve, Gordon B. Mills, Terence P. Speed, Heidi S. Feiler, Richard F. Wooster, David Haussler, Joshua M. Stuart, Joe W. Gray, and Paul T. Spellman
- You have accessGenome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifenAna M. Mendes-Pereira, David Sims, Tim Dexter, Kerry Fenwick, Ioannis Assiotis, Iwanka Kozarewa, Costas Mitsopoulos, Jarle Hakas, Marketa Zvelebil, Christopher J. Lord, and Alan Ashworth
- You have accessThe HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathwayKideok Jin, Xiangjun Kong, Tariq Shah, Marie-France Penet, Flonne Wildes, Dennis C. Sgroi, Xiao-Jun Ma, Yi Huang, Anne Kallioniemi, Goran Landberg, Ivan Bieche, Xinyan Wu, Peter E. Lobie, Nancy E. Davidson, Zaver M. Bhujwalla, Tao Zhu, and Saraswati Sukumar
- You have accessMaintenance of hormone responsiveness in luminal breast cancers by suppression of NotchJames M. Haughian, Mauricio P. Pinto, J. Chuck Harrell, Brian S. Bliesner, Kristiina M. Joensuu, Wendy W. Dye, Carol A. Sartorius, Aik Choon Tan, Päivi Heikkilä, Charles M. Perou, and Kathryn B. Horwitz
- You have accessTransducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cellsKelly A. Holmes, Antoni Hurtado, Gordon D. Brown, Rosalind Launchbury, Caryn S. Ross-Innes, James Hadfield, Duncan T. Odom, and Jason S. Carroll
- You have accessCyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteinsVasco Liberal, Hanna-Stina Martinsson-Ahlzén, Jennifer Liberal, Charles H. Spruck, Martin Widschwendter, Clare H. McGowan, and Steven I. Reed
- You have accessHomeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responsesNaokazu Chiba, Valentine Comaills, Bunsyo Shiotani, Fumiyuki Takahashi, Toshiyuki Shimada, Ken Tajima, Daniel Winokur, Tetsu Hayashida, Henning Willers, Elena Brachtel, Maria d. M. Vivanco, Daniel A. Haber, Lee Zou, and Shyamala Maheswaran
- You have accessSensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737Samantha R. Oakes, François Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E. Ritchie, Elena Takano, Teresa Ward, Stephen B. Fox, Daniele Generali, Gordon K. Smyth, Andreas Strasser, David C. S. Huang, Jane E. Visvader, and Geoffrey J. Lindeman
- You have accessDefining the cellular precursors to human breast cancerPatricia J. Keller, Lisa M. Arendt, Adam Skibinski, Tanya Logvinenko, Ina Klebba, Shumin Dong, Avi E. Smith, Aleix Prat, Charles M. Perou, Hannah Gilmore, Stuart Schnitt, Stephen P. Naber, Jonathan A. Garlick, and Charlotte Kuperwasser
- You have accessComparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cellsJason I. Herschkowitz, Wei Zhao, Mei Zhang, Jerry Usary, George Murrow, David Edwards, Jana Knezevic, Stephanie B. Greene, David Darr, Melissa A. Troester, Susan G. Hilsenbeck, Daniel Medina, Charles M. Perou, and Jeffrey M. Rosen
- You have accessAntiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxiaSarah J. Conley, Elizabeth Gheordunescu, Pramod Kakarala, Bryan Newman, Hasan Korkaya, Amber N. Heath, Shawn G. Clouthier, and Max S. Wicha
- You have accessMechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expressionXiaoli Zhang, Amy S. Farrell, Colin J. Daniel, Hugh Arnold, Charles Scanlan, Bryan J. Laraway, Mahnaz Janghorban, Lawrence Lum, Dexi Chen, Megan Troxell, and Rosalie Sears
- You have accessLeukocyte composition of human breast cancerBrian Ruffell, Alfred Au, Hope S. Rugo, Laura J. Esserman, E. Shelley Hwang, and Lisa M. Coussens
- You have accessIntegrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signalingVessela N. Kristensen, Charles J. Vaske, Josie Ursini-Siegel, Peter Van Loo, Silje H. Nordgard, Ravi Sachidanandam, Therese Sørlie, Fredrik Wärnberg, Vilde D. Haakensen, Åslaug Helland, Bjørn Naume, Charles M. Perou, David Haussler, Olga G. Troyanskaya, and Anne-Lise Børresen-Dale
- You have accessMammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesisRichard Marcotte, Harvey W. Smith, Virginie Sanguin-Gendreau, Rosalie V. McDonough, and William J. Muller
- You have accessDisruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediatorsPhilip Owens, Michael W. Pickup, Sergey V. Novitskiy, Anna Chytil, Agnieszka E. Gorska, Mary E. Aakre, James West, and Harold L. Moses
- You have accessAltered antisense-to-sense transcript ratios in breast cancerReo Maruyama, Michail Shipitsin, Sibgat Choudhury, Zhenhua Wu, Alexei Protopopov, Jun Yao, Pang-Kuo Lo, Marina Bessarabova, Alex Ishkin, Yuri Nikolsky, X. Shirley Liu, Saraswati Sukumar, and Kornelia Polyak
Physical Sciences
Applied Physical Sciences
- You have accessA small world of weak ties provides optimal global integration of self-similar modules in functional brain networksLazaros K. Gallos, Hernán A. Makse, and Mariano Sigman
- You have accessThe heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissueMichael W. Harman, Star M. Dunham-Ems, Melissa J. Caimano, Alexia A. Belperron, Linda K. Bockenstedt, Henry C. Fu, Justin D. Radolf, and Charles W. Wolgemuth
Chemistry
- Open AccessUnusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpeckerDorit Eliyahu, Satoshi Nojima, Richard G. Santangelo, Shannon Carpenter, Francis X. Webster, David J. Kiemle, Cesar Gemeno, Walter S. Leal, and Coby Schal
Earth, Atmospheric, and Planetary Sciences
- Open AccessA serpentinite-hosted ecosystem in the Southern Mariana ForearcYasuhiko Ohara, Mark K. Reagan, Katsunori Fujikura, Hiromi Watanabe, Katsuyoshi Michibayashi, Teruaki Ishii, Robert J. Stern, Ignacio Pujana, Fernando Martinez, Guillaume Girard, Julia Ribeiro, Maryjo Brounce, Naoaki Komori, and Masashi Kino
- You have accessNonequilibrium atmospheric secondary organic aerosol formation and growthVéronique Perraud, Emily A. Bruns, Michael J. Ezell, Stanley N. Johnson, Yong Yu, M. Lizabeth Alexander, Alla Zelenyuk, Dan Imre, Wayne L. Chang, Donald Dabdub, James F. Pankow, and Barbara J. Finlayson-Pitts
Mathematics
Statistics
- You have accessSignificance analysis of xMap cytokine bead arraysJoong-Ho Won, Ofir Goldberger, Shai S. Shen-Orr, Mark M. Davis, and Richard A. Olshen
Social Sciences
Anthropology
- You have accessHeterogeneity of hunting ability and nutritional status among domestic dogs in lowland NicaraguaJeremy M. Koster and Kenneth B. Tankersley
Psychological and Cognitive Sciences
- Open AccessMaternal support in early childhood predicts larger hippocampal volumes at school ageJoan L. Luby, Deanna M. Barch, Andy Belden, Michael S. Gaffrey, Rebecca Tillman, Casey Babb, Tomoyuki Nishino, Hideo Suzuki, and Kelly N. Botteron
Biological Sciences
Applied Biological Sciences
- You have accessTransducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cellsKelly A. Holmes, Antoni Hurtado, Gordon D. Brown, Rosalind Launchbury, Caryn S. Ross-Innes, James Hadfield, Duncan T. Odom, and Jason S. Carroll
Biochemistry
- Open AccessSTK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viabilityTuoping Luo, Kristina Masson, Jacob D. Jaffe, Whitney Silkworth, Nathan T. Ross, Christina A. Scherer, Claudia Scholl, Stefan Fröhling, Steven A. Carr, Andrew M. Stern, Stuart L. Schreiber, and Todd R. Golub
- You have accessSurprising complexity of the Asf1 histone chaperone-Rad53 kinase interactionYue Jiao, Karsten Seeger, Aurelie Lautrette, Albane Gaubert, Florence Mousson, Raphael Guerois, Carl Mann, and Françoise Ochsenbein
- Open AccessInterdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophanStephen N. Floor, Mark S. Borja, and John D. Gross
- You have accessTropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assemblyGiselle C. Yeo, Clair Baldock, Anne Tuukkanen, Manfred Roessle, Leanne B. Dyksterhuis, Steven G. Wise, Jacqueline Matthews, Suzanne M. Mithieux, and Anthony S. Weiss
Biophysics and Computational Biology
- Open AccessSubunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modelingNir Kalisman, Christopher M. Adams, and Michael Levitt
- Open AccessModeling and design by hierarchical natural moves
- From the Cover
Adelene Y. L. Sim, Michael Levitt, and Peter MinarySee companion article:
- RNA modeling, naturally- Feb 03, 2012
- Open AccessAnomalous Brownian motion discloses viscoelasticity in the ear’s mechanoelectrical-transduction apparatusAndrei S. Kozlov, Daniel Andor-Ardó, and A. J. Hudspeth
- You have accessEntropic origin of Mg2+-facilitated RNA foldingJulie L. Fiore, Erik D. Holmstrom, and David J. Nesbitt
- You have accessStructure of saposin A lipoprotein discsKonstantin Popovic, John Holyoake, Régis Pomès, and Gilbert G. Privé
- You have accessActin filament curvature biases branching directionViviana I. Risca, Evan B. Wang, Ovijit Chaudhuri, Jia Jun Chia, Phillip L. Geissler, and Daniel A. Fletcher
See companion article:
- Actin bends over backward for directional branching- Feb 09, 2012
- Open AccessAberration-free three-dimensional multiphoton imaging of neuronal activity at kHz ratesEdward J. Botcherby, Christopher W. Smith, Michael M. Kohl, Delphine Débarre, Martin J. Booth, Rimas Juškaitis, Ole Paulsen, and Tony Wilson
- Open AccessDNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNASanghwa Lee, Seung-Ryoung Jung, Kang Heo, Jo Ann W. Byl, Joseph E. Deweese, Neil Osheroff, and Sungchul Hohng
Cell Biology
- You have accessRabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosisDeanna M. Navaroli, Karl D. Bellvé, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera
- You have accessCyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteinsVasco Liberal, Hanna-Stina Martinsson-Ahlzén, Jennifer Liberal, Charles H. Spruck, Martin Widschwendter, Clare H. McGowan, and Steven I. Reed
- You have accessHomeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responsesNaokazu Chiba, Valentine Comaills, Bunsyo Shiotani, Fumiyuki Takahashi, Toshiyuki Shimada, Ken Tajima, Daniel Winokur, Tetsu Hayashida, Henning Willers, Elena Brachtel, Maria d. M. Vivanco, Daniel A. Haber, Lee Zou, and Shyamala Maheswaran
- You have accessMechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expressionXiaoli Zhang, Amy S. Farrell, Colin J. Daniel, Hugh Arnold, Charles Scanlan, Bryan J. Laraway, Mahnaz Janghorban, Lawrence Lum, Dexi Chen, Megan Troxell, and Rosalie Sears
- You have accessDisruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediatorsPhilip Owens, Michael W. Pickup, Sergey V. Novitskiy, Anna Chytil, Agnieszka E. Gorska, Mary E. Aakre, James West, and Harold L. Moses
- You have accessSkeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restrictionLydia W. S. Finley, Jaewon Lee, Amanda Souza, Valérie Desquiret-Dumas, Kevin Bullock, Glenn C. Rowe, Vincent Procaccio, Clary B. Clish, Zoltan Arany, and Marcia C. Haigis
- You have accessCharged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activityShinji Tsutsumi, Mehdi Mollapour, Chrisostomos Prodromou, Chung-Tien Lee, Barry Panaretou, Soichiro Yoshida, Matthias P. Mayer, and Leonard M. Neckers
- You have accessHydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy productionMing Fu, Weihua Zhang, Lingyun Wu, Guangdong Yang, Hongzhu Li, and Rui Wang
Developmental Biology
- You have accessCompensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte developmentPengpeng Ma, Hua Pan, Rusty L. Montgomery, Eric N. Olson, and Richard M. Schultz
- You have accessControl of target gene specificity during metamorphosis by the steroid response gene E93Xiaochun Mou, Dianne M. Duncan, Eric H. Baehrecke, and Ian Duncan
- You have accessA Y-linked anti-Müllerian hormone duplication takes over a critical role in sex determinationRicardo S. Hattori, Yu Murai, Miho Oura, Shuji Masuda, Sullip K. Majhi, Takashi Sakamoto, Juan I. Fernandino, Gustavo M. Somoza, Masashi Yokota, and Carlos A. Strüssmann
Ecology
- Open AccessUnusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpeckerDorit Eliyahu, Satoshi Nojima, Richard G. Santangelo, Shannon Carpenter, Francis X. Webster, David J. Kiemle, Cesar Gemeno, Walter S. Leal, and Coby Schal
- Open AccessA serpentinite-hosted ecosystem in the Southern Mariana ForearcYasuhiko Ohara, Mark K. Reagan, Katsunori Fujikura, Hiromi Watanabe, Katsuyoshi Michibayashi, Teruaki Ishii, Robert J. Stern, Ignacio Pujana, Fernando Martinez, Guillaume Girard, Julia Ribeiro, Maryjo Brounce, Naoaki Komori, and Masashi Kino
Evolution
- You have access“Evolution Canyon,” a potential microscale monitor of global warming across lifeEviatar Nevo
- You have accessEnzyme functional evolution through improved catalysis of ancestrally nonpreferred substratesRuiqi Huang, Frank Hippauf, Diana Rohrbeck, Maria Haustein, Katrin Wenke, Janie Feike, Noah Sorrelle, Birgit Piechulla, and Todd J. Barkman
Genetics
- You have accessComparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cellsJason I. Herschkowitz, Wei Zhao, Mei Zhang, Jerry Usary, George Murrow, David Edwards, Jana Knezevic, Stephanie B. Greene, David Darr, Melissa A. Troester, Susan G. Hilsenbeck, Daniel Medina, Charles M. Perou, and Jeffrey M. Rosen
- Open AccessHuman genetic variation altering anthrax toxin sensitivityMikhail Martchenko, Sophie I. Candille, Hua Tang, and Stanley N. Cohen
- You have accessCongenital diaphragmatic hernia candidate genes derived from embryonic transcriptomesMeaghan K. Russell, Mauro Longoni, Julie Wells, Faouzi I. Maalouf, Adam A. Tracy, Maria Loscertales, Kate G. Ackerman, Barbara R. Pober, Kasper Lage, Carol J. Bult, and Patricia K. Donahoe
- You have accessExposure to anticancer drugs can result in transgenerational genomic instability in miceColin D. Glen and Yuri E. Dubrova
- Open AccessMutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)Michael T. McCabe, Alan P. Graves, Gopinath Ganji, Elsie Diaz, Wendy S. Halsey, Yong Jiang, Kimberly N. Smitheman, Heidi M. Ott, Melissa B. Pappalardi, Kimberly E. Allen, Stephanie B. Chen, Anthony Della Pietra III, Edward Dul, Ashley M. Hughes, Seth A. Gilbert, Sara H. Thrall, Peter J. Tummino, Ryan G. Kruger, Martin Brandt, Benjamin Schwartz, and Caretha L. Creasy
- You have accessDefective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeriaIrene Kamileri, Ismene Karakasilioti, Aria Sideri, Theodoros Kosteas, Antonis Tatarakis, Iannis Talianidis, and George A. Garinis
Immunology
- You have accessLeukocyte composition of human breast cancerBrian Ruffell, Alfred Au, Hope S. Rugo, Laura J. Esserman, E. Shelley Hwang, and Lisa M. Coussens
- You have accessSignificance analysis of xMap cytokine bead arraysJoong-Ho Won, Ofir Goldberger, Shai S. Shen-Orr, Mark M. Davis, and Richard A. Olshen
- You have accessIL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonistFrank L. van de Veerdonk, Angela K. Stoeckman, Gouping Wu, Aaron N. Boeckermann, Tania Azam, Mihai G. Netea, Leo A. B. Joosten, Jos W. M. van der Meer, Ruyi Hao, Vassili Kalabokis, and Charles A. Dinarello
- You have accessProtein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cellsGiovanna Clavarino, Nuno Cláudio, Alexandre Dalet, Seigo Terawaki, Thérèse Couderc, Lionel Chasson, Maurizio Ceppi, Enrico K. Schmidt, Till Wenger, Marc Lecuit, Evelina Gatti, and Philippe Pierre
- Open AccessPlasmacytoid dendritic cells control T-cell response to chronic viral infectionLuisa Cervantes-Barragan, Kanako L. Lewis, Sonja Firner, Volker Thiel, Stephanie Hugues, Walter Reith, Burkhard Ludewig, and Boris Reizis
Medical Sciences
- You have accessFeedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitorsAnindita Chakrabarty, Violeta Sánchez, María G. Kuba, Cammie Rinehart, and Carlos L. Arteaga
- You have accessGenome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifenAna M. Mendes-Pereira, David Sims, Tim Dexter, Kerry Fenwick, Ioannis Assiotis, Iwanka Kozarewa, Costas Mitsopoulos, Jarle Hakas, Marketa Zvelebil, Christopher J. Lord, and Alan Ashworth
- You have accessThe HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathwayKideok Jin, Xiangjun Kong, Tariq Shah, Marie-France Penet, Flonne Wildes, Dennis C. Sgroi, Xiao-Jun Ma, Yi Huang, Anne Kallioniemi, Goran Landberg, Ivan Bieche, Xinyan Wu, Peter E. Lobie, Nancy E. Davidson, Zaver M. Bhujwalla, Tao Zhu, and Saraswati Sukumar
- You have accessMaintenance of hormone responsiveness in luminal breast cancers by suppression of NotchJames M. Haughian, Mauricio P. Pinto, J. Chuck Harrell, Brian S. Bliesner, Kristiina M. Joensuu, Wendy W. Dye, Carol A. Sartorius, Aik Choon Tan, Päivi Heikkilä, Charles M. Perou, and Kathryn B. Horwitz
- You have accessSensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737Samantha R. Oakes, François Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E. Ritchie, Elena Takano, Teresa Ward, Stephen B. Fox, Daniele Generali, Gordon K. Smyth, Andreas Strasser, David C. S. Huang, Jane E. Visvader, and Geoffrey J. Lindeman
- You have accessDefining the cellular precursors to human breast cancerPatricia J. Keller, Lisa M. Arendt, Adam Skibinski, Tanya Logvinenko, Ina Klebba, Shumin Dong, Avi E. Smith, Aleix Prat, Charles M. Perou, Hannah Gilmore, Stuart Schnitt, Stephen P. Naber, Jonathan A. Garlick, and Charlotte Kuperwasser
- You have accessAntiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxiaSarah J. Conley, Elizabeth Gheordunescu, Pramod Kakarala, Bryan Newman, Hasan Korkaya, Amber N. Heath, Shawn G. Clouthier, and Max S. Wicha
- You have accessIntegrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signalingVessela N. Kristensen, Charles J. Vaske, Josie Ursini-Siegel, Peter Van Loo, Silje H. Nordgard, Ravi Sachidanandam, Therese Sørlie, Fredrik Wärnberg, Vilde D. Haakensen, Åslaug Helland, Bjørn Naume, Charles M. Perou, David Haussler, Olga G. Troyanskaya, and Anne-Lise Børresen-Dale
- You have accessMammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesisRichard Marcotte, Harvey W. Smith, Virginie Sanguin-Gendreau, Rosalie V. McDonough, and William J. Muller
- You have accessAltered antisense-to-sense transcript ratios in breast cancerReo Maruyama, Michail Shipitsin, Sibgat Choudhury, Zhenhua Wu, Alexei Protopopov, Jun Yao, Pang-Kuo Lo, Marina Bessarabova, Alex Ishkin, Yuri Nikolsky, X. Shirley Liu, Saraswati Sukumar, and Kornelia Polyak
- You have accessPhosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesisHaizhong Feng, Bo Hu, Michael J. Jarzynka, Yanxin Li, Susan Keezer, Terrance G. Johns, Careen K. Tang, Ronald L. Hamilton, Kristiina Vuori, Ryo Nishikawa, Jann N. Sarkaria, Tim Fenton, Tao Cheng, Frank B. Furnari, Webster K. Cavenee, and Shi-Yuan Cheng
- Open AccessBreast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNAStefano Volinia, Marco Galasso, Maria Elena Sana, Timothy F. Wise, Jeff Palatini, Kay Huebner, and Carlo M. Croce
- You have accessCentral diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor βChiara Gabbi, Xiaomu Kong, Hitoshi Suzuki, Hyun-Jin Kim, Min Gao, Xiao Jia, Hideo Ohnishi, Yoichi Ueta, Margaret Warner, Youfei Guan, and Jan-Åke Gustafsson
- You have accessRole of retroviral restriction factors in the interferon-α–mediated suppression of HIV-1 in vivoSatish K. Pillai, Mohamed Abdel-Mohsen, John Guatelli, Mark Skasko, Alexander Monto, Katsuya Fujimoto, Steven Yukl, Warner C. Greene, Helen Kovari, Andri Rauch, Jacques Fellay, Manuel Battegay, Bernard Hirschel, Andrea Witteck, Enos Bernasconi, Bruno Ledergerber, Huldrych F. Günthard, Joseph K. Wong, and the Swiss HIV Cohort Study
- Open AccessIntratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor responseNicholas J. Szerlip, Alicia Pedraza, Debyani Chakravarty, Mohammad Azim, Jeremy McGuire, Yuqiang Fang, Tatsuya Ozawa, Eric C. Holland, Jason T. Huse, Suresh Jhanwar, Margaret A. Leversha, Tom Mikkelsen, and Cameron W. Brennan
- You have accessEssential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signalingCaroline Bonnans, Maud Flacelière, Fanny Grillet, Christelle Dantec, Jean-Pierre Desvignes, Julie Pannequin, Dany Severac, Emeric Dubois, Frédéric Bibeau, Virginie Escriou, Philippe Crespy, Laurent Journot, Frédéric Hollande, and Dominique Joubert
- You have accessInactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesisZehua Wang, Zemin Wang, Jianhui Guo, Yingchun Li, Jasmin H. Bavarva, Chiping Qian, M. Christiane Brahimi-Horn, Deyong Tan, and Wanguo Liu
Microbiology
- Open AccessMevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatusSabiha Yasmin, Laura Alcazar-Fuoli, Mario Gründlinger, Thomas Puempel, Timothy Cairns, Michael Blatzer, Jordi F. Lopez, Joan O. Grimalt, Elaine Bignell, and Hubertus Haas
- You have accessThe heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissueMichael W. Harman, Star M. Dunham-Ems, Melissa J. Caimano, Alexia A. Belperron, Linda K. Bockenstedt, Henry C. Fu, Justin D. Radolf, and Charles W. Wolgemuth
- Open AccessGenomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011Yonatan H. Grad, Marc Lipsitch, Michael Feldgarden, Harindra M. Arachchi, Gustavo C. Cerqueira, Michael FitzGerald, Paul Godfrey, Brian J. Haas, Cheryl I. Murphy, Carsten Russ, Sean Sykes, Bruce J. Walker, Jennifer R. Wortman, Sarah Young, Qiandong Zeng, Amr Abouelleil, James Bochicchio, Sara Chauvin, Timothy DeSmet, Sharvari Gujja, Caryn McCowan, Anna Montmayeur, Scott Steelman, Jakob Frimodt-Møller, Andreas M. Petersen, Carsten Struve, Karen A. Krogfelt, Edouard Bingen, François-Xavier Weill, Eric S. Lander, Chad Nusbaum, Bruce W. Birren, Deborah T. Hung, and William P. Hanage
See companion article:
- Support for a bottleneck in the O104:H4 outbreaks- Dec 17, 2012
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