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Table of Contents

February 21, 2012; vol. 109 no. 8

This Week in PNAS

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    In This Issue
    PNAS February 21, 2012 109 (8) 2685-3190; https://doi.org/10.1073/iti0812109

Letters (Online Only)

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    Viruses do replicate in cell-free systems
    Yervand E. Karapetyan
    PNAS February 21, 2012 109 (8) E461; https://doi.org/10.1073/pnas.1118908109
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    Reply to Karapetyan: Viral synthesis and assembly is unlikely to occur under cell-free PMCA conditions
    Bruce Chesebro, Mikael Klingeborn, and Brent Race
    PNAS February 21, 2012 109 (8) E462; https://doi.org/10.1073/pnas.1120371109

QnAs

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    QnAs with Richard T. Durrett
    Sandeep Ravindran
    PNAS February 21, 2012 109 (8) 2687; https://doi.org/10.1073/pnas.1121488109

Profile

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    Profile of Robert B. Goldberg
    Nicholette Zeliadt
    PNAS February 21, 2012 109 (8) 2688-2690; https://doi.org/10.1073/pnas.1121586109

    See companion article:

    • Global analysis of gene activity during Arabidopsis seed development and identification of seed-specific transcription factors
      - Apr 12, 2010

Commentaries

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    RNA modeling, naturally
    Eric Westhof
    PNAS February 21, 2012 109 (8) 2691-2692; https://doi.org/10.1073/pnas.1121363109

    See companion article:

    • Modeling and design by hierarchical natural moves
      - Jan 23, 2012
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    Actin bends over backward for directional branching
    Tatyana M. Svitkina
    PNAS February 21, 2012 109 (8) 2693-2694; https://doi.org/10.1073/pnas.1121360109

    See companion article:

    • Actin filament curvature biases branching direction
      - Jan 30, 2012
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    MicroRNA expression by an oncogenic retrovirus
    Bryan R. Cullen
    PNAS February 21, 2012 109 (8) 2695-2696; https://doi.org/10.1073/pnas.1200328109

    See companion article:

    • RNA virus microRNA that mimics a B-cell oncomiR
      - Jan 30, 2012
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    Shifting pharmacology of nicotine use and withdrawal: Breaking the cycle of drug abuse
    Thibaut Sesia and Anthony A. Grace
    PNAS February 21, 2012 109 (8) 2697-2698; https://doi.org/10.1073/pnas.1200179109

    See companion article:

    • Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal
      - Jan 20, 2012
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    AgRP neurons: The foes of reproduction in leptin-deficient obese subjects
    Marcelo O. Dietrich and Tamas L. Horvath
    PNAS February 21, 2012 109 (8) 2699-2700; https://doi.org/10.1073/pnas.1121355109

    See companion article:

    • Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
      - Jan 09, 2012

PNAS Plus (Author Summaries and Research Articles)

  • Physical Sciences – Chemistry – Biological Sciences – Ecology

    • Open Access
      Unusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpecker
      Dorit Eliyahu, Satoshi Nojima, Richard G. Santangelo, Shannon Carpenter, Francis X. Webster, David J. Kiemle, Cesar Gemeno, Walter S. Leal, and Coby Schal
      PNAS February 21, 2012 109 (8) E490-E496; https://doi.org/10.1073/pnas.1111748109
  • Social Sciences – Anthropology

    • You have access
      Heterogeneity of hunting ability and nutritional status among domestic dogs in lowland Nicaragua
      Jeremy M. Koster and Kenneth B. Tankersley
      PNAS February 21, 2012 109 (8) E463-E470; https://doi.org/10.1073/pnas.1112515109
  • Biological Sciences – Cell Biology

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      Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis
      Deanna M. Navaroli, Karl D. Bellvé, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera
      PNAS February 21, 2012 109 (8) E471-E480; https://doi.org/10.1073/pnas.1115495109
  • Biological Sciences – Developmental Biology

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      Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development
      Pengpeng Ma, Hua Pan, Rusty L. Montgomery, Eric N. Olson, and Richard M. Schultz
      PNAS February 21, 2012 109 (8) E481-E489; https://doi.org/10.1073/pnas.1118403109
  • Biological Sciences – Microbiology

    • Open Access
      Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus
      Sabiha Yasmin, Laura Alcazar-Fuoli, Mario Gründlinger, Thomas Puempel, Timothy Cairns, Michael Blatzer, Jordi F. Lopez, Joan O. Grimalt, Elaine Bignell, and Hubertus Haas
      PNAS February 21, 2012 109 (8) E497-E504; https://doi.org/10.1073/pnas.1106399108
  • Biological Sciences – Neuroscience

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      Phoneme and word recognition in the auditory ventral stream
      Iain DeWitt and Josef P. Rauschecker
      PNAS February 21, 2012 109 (8) E505-E514; https://doi.org/10.1073/pnas.1113427109
    • Open Access
      Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses
      Xuelin Lou, Fan Fan, Mirko Messa, Andrea Raimondi, Yumei Wu, Loren L. Looger, Shawn M. Ferguson, and Pietro De Camilli
      PNAS February 21, 2012 109 (8) E515-E523; https://doi.org/10.1073/pnas.1121626109
  • Biological Sciences – Physiology

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      Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
      George A. Kyriazis, Mangala M. Soundarapandian, and Björn Tyrberg
      PNAS February 21, 2012 109 (8) E524-E532; https://doi.org/10.1073/pnas.1115183109

Breast Cancer Special Feature (free online)

  • Introduction

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      Progress in breast cancer research
      • From the Cover
      Kornelia Polyak and Peter K. Vogt
      PNAS February 21, 2012 109 (8) 2715-2717; https://doi.org/10.1073/pnas.1201091109
  • Research Articles

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      Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors
      Anindita Chakrabarty, Violeta Sánchez, María G. Kuba, Cammie Rinehart, and Carlos L. Arteaga
      PNAS February 21, 2012 109 (8) 2718-2723; https://doi.org/10.1073/pnas.1018001108
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      Subtype and pathway specific responses to anticancer compounds in breast cancer
      Laura M. Heiser, Anguraj Sadanandam, Wen-Lin Kuo, Stephen C. Benz, Theodore C. Goldstein, Sam Ng, William J. Gibb, Nicholas J. Wang, Safiyyah Ziyad, Frances Tong, Nora Bayani, Zhi Hu, Jessica I. Billig, Andrea Dueregger, Sophia Lewis, Lakshmi Jakkula, James E. Korkola, Steffen Durinck, François Pepin, Yinghui Guan, Elizabeth Purdom, Pierre Neuvial, Henrik Bengtsson, Kenneth W. Wood, Peter G. Smith, Lyubomir T. Vassilev, Bryan T. Hennessy, Joel Greshock, Kurtis E. Bachman, Mary Ann Hardwicke, John W. Park, Laurence J. Marton, Denise M. Wolf, Eric A. Collisson, Richard M. Neve, Gordon B. Mills, Terence P. Speed, Heidi S. Feiler, Richard F. Wooster, David Haussler, Joshua M. Stuart, Joe W. Gray, and Paul T. Spellman
      PNAS February 21, 2012 109 (8) 2724-2729; https://doi.org/10.1073/pnas.1018854108
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      Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen
      Ana M. Mendes-Pereira, David Sims, Tim Dexter, Kerry Fenwick, Ioannis Assiotis, Iwanka Kozarewa, Costas Mitsopoulos, Jarle Hakas, Marketa Zvelebil, Christopher J. Lord, and Alan Ashworth
      PNAS February 21, 2012 109 (8) 2730-2735; https://doi.org/10.1073/pnas.1018872108
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      The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway
      Kideok Jin, Xiangjun Kong, Tariq Shah, Marie-France Penet, Flonne Wildes, Dennis C. Sgroi, Xiao-Jun Ma, Yi Huang, Anne Kallioniemi, Goran Landberg, Ivan Bieche, Xinyan Wu, Peter E. Lobie, Nancy E. Davidson, Zaver M. Bhujwalla, Tao Zhu, and Saraswati Sukumar
      PNAS February 21, 2012 109 (8) 2736-2741; https://doi.org/10.1073/pnas.1018859108
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      Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch
      James M. Haughian, Mauricio P. Pinto, J. Chuck Harrell, Brian S. Bliesner, Kristiina M. Joensuu, Wendy W. Dye, Carol A. Sartorius, Aik Choon Tan, Päivi Heikkilä, Charles M. Perou, and Kathryn B. Horwitz
      PNAS February 21, 2012 109 (8) 2742-2747; https://doi.org/10.1073/pnas.1106509108
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      Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells
      Kelly A. Holmes, Antoni Hurtado, Gordon D. Brown, Rosalind Launchbury, Caryn S. Ross-Innes, James Hadfield, Duncan T. Odom, and Jason S. Carroll
      PNAS February 21, 2012 109 (8) 2748-2753; https://doi.org/10.1073/pnas.1018863108
    • You have access
      Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins
      Vasco Liberal, Hanna-Stina Martinsson-Ahlzén, Jennifer Liberal, Charles H. Spruck, Martin Widschwendter, Clare H. McGowan, and Steven I. Reed
      PNAS February 21, 2012 109 (8) 2754-2759; https://doi.org/10.1073/pnas.1102434108
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      Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses
      Naokazu Chiba, Valentine Comaills, Bunsyo Shiotani, Fumiyuki Takahashi, Toshiyuki Shimada, Ken Tajima, Daniel Winokur, Tetsu Hayashida, Henning Willers, Elena Brachtel, Maria d. M. Vivanco, Daniel A. Haber, Lee Zou, and Shyamala Maheswaran
      PNAS February 21, 2012 109 (8) 2760-2765; https://doi.org/10.1073/pnas.1018867108
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      Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737
      Samantha R. Oakes, François Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E. Ritchie, Elena Takano, Teresa Ward, Stephen B. Fox, Daniele Generali, Gordon K. Smyth, Andreas Strasser, David C. S. Huang, Jane E. Visvader, and Geoffrey J. Lindeman
      PNAS February 21, 2012 109 (8) 2766-2771; https://doi.org/10.1073/pnas.1104778108
    • You have access
      Defining the cellular precursors to human breast cancer
      Patricia J. Keller, Lisa M. Arendt, Adam Skibinski, Tanya Logvinenko, Ina Klebba, Shumin Dong, Avi E. Smith, Aleix Prat, Charles M. Perou, Hannah Gilmore, Stuart Schnitt, Stephen P. Naber, Jonathan A. Garlick, and Charlotte Kuperwasser
      PNAS February 21, 2012 109 (8) 2772-2777; https://doi.org/10.1073/pnas.1017626108
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      Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells
      Jason I. Herschkowitz, Wei Zhao, Mei Zhang, Jerry Usary, George Murrow, David Edwards, Jana Knezevic, Stephanie B. Greene, David Darr, Melissa A. Troester, Susan G. Hilsenbeck, Daniel Medina, Charles M. Perou, and Jeffrey M. Rosen
      PNAS February 21, 2012 109 (8) 2778-2783; https://doi.org/10.1073/pnas.1018862108
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      Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
      Sarah J. Conley, Elizabeth Gheordunescu, Pramod Kakarala, Bryan Newman, Hasan Korkaya, Amber N. Heath, Shawn G. Clouthier, and Max S. Wicha
      PNAS February 21, 2012 109 (8) 2784-2789; https://doi.org/10.1073/pnas.1018866109
    • You have access
      Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression
      Xiaoli Zhang, Amy S. Farrell, Colin J. Daniel, Hugh Arnold, Charles Scanlan, Bryan J. Laraway, Mahnaz Janghorban, Lawrence Lum, Dexi Chen, Megan Troxell, and Rosalie Sears
      PNAS February 21, 2012 109 (8) 2790-2795; https://doi.org/10.1073/pnas.1100764108
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      Leukocyte composition of human breast cancer
      Brian Ruffell, Alfred Au, Hope S. Rugo, Laura J. Esserman, E. Shelley Hwang, and Lisa M. Coussens
      PNAS February 21, 2012 109 (8) 2796-2801; https://doi.org/10.1073/pnas.1104303108
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      Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
      Vessela N. Kristensen, Charles J. Vaske, Josie Ursini-Siegel, Peter Van Loo, Silje H. Nordgard, Ravi Sachidanandam, Therese Sørlie, Fredrik Wärnberg, Vilde D. Haakensen, Åslaug Helland, Bjørn Naume, Charles M. Perou, David Haussler, Olga G. Troyanskaya, and Anne-Lise Børresen-Dale
      PNAS February 21, 2012 109 (8) 2802-2807; https://doi.org/10.1073/pnas.1108781108
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      Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis
      Richard Marcotte, Harvey W. Smith, Virginie Sanguin-Gendreau, Rosalie V. McDonough, and William J. Muller
      PNAS February 21, 2012 109 (8) 2808-2813; https://doi.org/10.1073/pnas.1018861108
    • You have access
      Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators
      Philip Owens, Michael W. Pickup, Sergey V. Novitskiy, Anna Chytil, Agnieszka E. Gorska, Mary E. Aakre, James West, and Harold L. Moses
      PNAS February 21, 2012 109 (8) 2814-2819; https://doi.org/10.1073/pnas.1101139108
    • You have access
      Altered antisense-to-sense transcript ratios in breast cancer
      Reo Maruyama, Michail Shipitsin, Sibgat Choudhury, Zhenhua Wu, Alexei Protopopov, Jun Yao, Pang-Kuo Lo, Marina Bessarabova, Alex Ishkin, Yuri Nikolsky, X. Shirley Liu, Saraswati Sukumar, and Kornelia Polyak
      PNAS February 21, 2012 109 (8) 2820-2824; https://doi.org/10.1073/pnas.1010559107

Physical Sciences

  • Applied Physical Sciences

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      A small world of weak ties provides optimal global integration of self-similar modules in functional brain networks
      Lazaros K. Gallos, Hernán A. Makse, and Mariano Sigman
      PNAS February 21, 2012 109 (8) 2825-2830; https://doi.org/10.1073/pnas.1106612109
    • You have access
      The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue
      Michael W. Harman, Star M. Dunham-Ems, Melissa J. Caimano, Alexia A. Belperron, Linda K. Bockenstedt, Henry C. Fu, Justin D. Radolf, and Charles W. Wolgemuth
      PNAS February 21, 2012 109 (8) 3059-3064; https://doi.org/10.1073/pnas.1114362109
  • Chemistry

    • Open Access
      Unusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpecker
      Dorit Eliyahu, Satoshi Nojima, Richard G. Santangelo, Shannon Carpenter, Francis X. Webster, David J. Kiemle, Cesar Gemeno, Walter S. Leal, and Coby Schal
      PNAS February 21, 2012 109 (8) E490-E496; https://doi.org/10.1073/pnas.1111748109
  • Earth, Atmospheric, and Planetary Sciences

    • Open Access
      A serpentinite-hosted ecosystem in the Southern Mariana Forearc
      Yasuhiko Ohara, Mark K. Reagan, Katsunori Fujikura, Hiromi Watanabe, Katsuyoshi Michibayashi, Teruaki Ishii, Robert J. Stern, Ignacio Pujana, Fernando Martinez, Guillaume Girard, Julia Ribeiro, Maryjo Brounce, Naoaki Komori, and Masashi Kino
      PNAS February 21, 2012 109 (8) 2831-2835; https://doi.org/10.1073/pnas.1112005109
    • You have access
      Nonequilibrium atmospheric secondary organic aerosol formation and growth
      Véronique Perraud, Emily A. Bruns, Michael J. Ezell, Stanley N. Johnson, Yong Yu, M. Lizabeth Alexander, Alla Zelenyuk, Dan Imre, Wayne L. Chang, Donald Dabdub, James F. Pankow, and Barbara J. Finlayson-Pitts
      PNAS February 21, 2012 109 (8) 2836-2841; https://doi.org/10.1073/pnas.1119909109
  • Mathematics

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      Approximately diagonalizing matrices over C(Y)
      Huaxin Lin
      PNAS February 21, 2012 109 (8) 2842-2847; https://doi.org/10.1073/pnas.1101079108
  • Statistics

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      Significance analysis of xMap cytokine bead arrays
      Joong-Ho Won, Ofir Goldberger, Shai S. Shen-Orr, Mark M. Davis, and Richard A. Olshen
      PNAS February 21, 2012 109 (8) 2848-2853; https://doi.org/10.1073/pnas.1112599109

Social Sciences

  • Anthropology

    • You have access
      Heterogeneity of hunting ability and nutritional status among domestic dogs in lowland Nicaragua
      Jeremy M. Koster and Kenneth B. Tankersley
      PNAS February 21, 2012 109 (8) E463-E470; https://doi.org/10.1073/pnas.1112515109
  • Psychological and Cognitive Sciences

    • Open Access
      Maternal support in early childhood predicts larger hippocampal volumes at school age
      Joan L. Luby, Deanna M. Barch, Andy Belden, Michael S. Gaffrey, Rebecca Tillman, Casey Babb, Tomoyuki Nishino, Hideo Suzuki, and Kelly N. Botteron
      PNAS February 21, 2012 109 (8) 2854-2859; https://doi.org/10.1073/pnas.1118003109

Biological Sciences

  • Applied Biological Sciences

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      Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells
      Kelly A. Holmes, Antoni Hurtado, Gordon D. Brown, Rosalind Launchbury, Caryn S. Ross-Innes, James Hadfield, Duncan T. Odom, and Jason S. Carroll
      PNAS February 21, 2012 109 (8) 2748-2753; https://doi.org/10.1073/pnas.1018863108
  • Biochemistry

    • Open Access
      STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability
      Tuoping Luo, Kristina Masson, Jacob D. Jaffe, Whitney Silkworth, Nathan T. Ross, Christina A. Scherer, Claudia Scholl, Stefan Fröhling, Steven A. Carr, Andrew M. Stern, Stuart L. Schreiber, and Todd R. Golub
      PNAS February 21, 2012 109 (8) 2860-2865; https://doi.org/10.1073/pnas.1120589109
    • You have access
      Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interaction
      Yue Jiao, Karsten Seeger, Aurelie Lautrette, Albane Gaubert, Florence Mousson, Raphael Guerois, Carl Mann, and Françoise Ochsenbein
      PNAS February 21, 2012 109 (8) 2866-2871; https://doi.org/10.1073/pnas.1106023109
    • Open Access
      Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan
      Stephen N. Floor, Mark S. Borja, and John D. Gross
      PNAS February 21, 2012 109 (8) 2872-2877; https://doi.org/10.1073/pnas.1113620109
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      Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly
      Giselle C. Yeo, Clair Baldock, Anne Tuukkanen, Manfred Roessle, Leanne B. Dyksterhuis, Steven G. Wise, Jacqueline Matthews, Suzanne M. Mithieux, and Anthony S. Weiss
      PNAS February 21, 2012 109 (8) 2878-2883; https://doi.org/10.1073/pnas.1111615108
  • Biophysics and Computational Biology

    • Open Access
      Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling
      Nir Kalisman, Christopher M. Adams, and Michael Levitt
      PNAS February 21, 2012 109 (8) 2884-2889; https://doi.org/10.1073/pnas.1119472109
    • Open Access
      Modeling and design by hierarchical natural moves
      • From the Cover
      Adelene Y. L. Sim, Michael Levitt, and Peter Minary
      PNAS February 21, 2012 109 (8) 2890-2895; https://doi.org/10.1073/pnas.1119918109

      See companion article:

      • RNA modeling, naturally
        - Feb 03, 2012
    • Open Access
      Anomalous Brownian motion discloses viscoelasticity in the ear’s mechanoelectrical-transduction apparatus
      Andrei S. Kozlov, Daniel Andor-Ardó, and A. J. Hudspeth
      PNAS February 21, 2012 109 (8) 2896-2901; https://doi.org/10.1073/pnas.1121389109
    • You have access
      Entropic origin of Mg2+-facilitated RNA folding
      Julie L. Fiore, Erik D. Holmstrom, and David J. Nesbitt
      PNAS February 21, 2012 109 (8) 2902-2907; https://doi.org/10.1073/pnas.1114859109
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      Structure of saposin A lipoprotein discs
      Konstantin Popovic, John Holyoake, Régis Pomès, and Gilbert G. Privé
      PNAS February 21, 2012 109 (8) 2908-2912; https://doi.org/10.1073/pnas.1115743109
    • You have access
      Actin filament curvature biases branching direction
      Viviana I. Risca, Evan B. Wang, Ovijit Chaudhuri, Jia Jun Chia, Phillip L. Geissler, and Daniel A. Fletcher
      PNAS February 21, 2012 109 (8) 2913-2918; https://doi.org/10.1073/pnas.1114292109

      See companion article:

      • Actin bends over backward for directional branching
        - Feb 09, 2012
    • Open Access
      Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates
      Edward J. Botcherby, Christopher W. Smith, Michael M. Kohl, Delphine Débarre, Martin J. Booth, Rimas Juškaitis, Ole Paulsen, and Tony Wilson
      PNAS February 21, 2012 109 (8) 2919-2924; https://doi.org/10.1073/pnas.1111662109
    • Open Access
      DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA
      Sanghwa Lee, Seung-Ryoung Jung, Kang Heo, Jo Ann W. Byl, Joseph E. Deweese, Neil Osheroff, and Sungchul Hohng
      PNAS February 21, 2012 109 (8) 2925-2930; https://doi.org/10.1073/pnas.1115704109
  • Cell Biology

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      Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis
      Deanna M. Navaroli, Karl D. Bellvé, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera
      PNAS February 21, 2012 109 (8) E471-E480; https://doi.org/10.1073/pnas.1115495109
    • You have access
      Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins
      Vasco Liberal, Hanna-Stina Martinsson-Ahlzén, Jennifer Liberal, Charles H. Spruck, Martin Widschwendter, Clare H. McGowan, and Steven I. Reed
      PNAS February 21, 2012 109 (8) 2754-2759; https://doi.org/10.1073/pnas.1102434108
    • You have access
      Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses
      Naokazu Chiba, Valentine Comaills, Bunsyo Shiotani, Fumiyuki Takahashi, Toshiyuki Shimada, Ken Tajima, Daniel Winokur, Tetsu Hayashida, Henning Willers, Elena Brachtel, Maria d. M. Vivanco, Daniel A. Haber, Lee Zou, and Shyamala Maheswaran
      PNAS February 21, 2012 109 (8) 2760-2765; https://doi.org/10.1073/pnas.1018867108
    • You have access
      Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression
      Xiaoli Zhang, Amy S. Farrell, Colin J. Daniel, Hugh Arnold, Charles Scanlan, Bryan J. Laraway, Mahnaz Janghorban, Lawrence Lum, Dexi Chen, Megan Troxell, and Rosalie Sears
      PNAS February 21, 2012 109 (8) 2790-2795; https://doi.org/10.1073/pnas.1100764108
    • You have access
      Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators
      Philip Owens, Michael W. Pickup, Sergey V. Novitskiy, Anna Chytil, Agnieszka E. Gorska, Mary E. Aakre, James West, and Harold L. Moses
      PNAS February 21, 2012 109 (8) 2814-2819; https://doi.org/10.1073/pnas.1101139108
    • You have access
      Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction
      Lydia W. S. Finley, Jaewon Lee, Amanda Souza, Valérie Desquiret-Dumas, Kevin Bullock, Glenn C. Rowe, Vincent Procaccio, Clary B. Clish, Zoltan Arany, and Marcia C. Haigis
      PNAS February 21, 2012 109 (8) 2931-2936; https://doi.org/10.1073/pnas.1115813109
    • You have access
      Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity
      Shinji Tsutsumi, Mehdi Mollapour, Chrisostomos Prodromou, Chung-Tien Lee, Barry Panaretou, Soichiro Yoshida, Matthias P. Mayer, and Leonard M. Neckers
      PNAS February 21, 2012 109 (8) 2937-2942; https://doi.org/10.1073/pnas.1114414109
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      Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production
      Ming Fu, Weihua Zhang, Lingyun Wu, Guangdong Yang, Hongzhu Li, and Rui Wang
      PNAS February 21, 2012 109 (8) 2943-2948; https://doi.org/10.1073/pnas.1115634109
  • Developmental Biology

    • You have access
      Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development
      Pengpeng Ma, Hua Pan, Rusty L. Montgomery, Eric N. Olson, and Richard M. Schultz
      PNAS February 21, 2012 109 (8) E481-E489; https://doi.org/10.1073/pnas.1118403109
    • You have access
      Control of target gene specificity during metamorphosis by the steroid response gene E93
      Xiaochun Mou, Dianne M. Duncan, Eric H. Baehrecke, and Ian Duncan
      PNAS February 21, 2012 109 (8) 2949-2954; https://doi.org/10.1073/pnas.1117559109
    • You have access
      A Y-linked anti-Müllerian hormone duplication takes over a critical role in sex determination
      Ricardo S. Hattori, Yu Murai, Miho Oura, Shuji Masuda, Sullip K. Majhi, Takashi Sakamoto, Juan I. Fernandino, Gustavo M. Somoza, Masashi Yokota, and Carlos A. Strüssmann
      PNAS February 21, 2012 109 (8) 2955-2959; https://doi.org/10.1073/pnas.1018392109
  • Ecology

    • Open Access
      Unusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpecker
      Dorit Eliyahu, Satoshi Nojima, Richard G. Santangelo, Shannon Carpenter, Francis X. Webster, David J. Kiemle, Cesar Gemeno, Walter S. Leal, and Coby Schal
      PNAS February 21, 2012 109 (8) E490-E496; https://doi.org/10.1073/pnas.1111748109
    • Open Access
      A serpentinite-hosted ecosystem in the Southern Mariana Forearc
      Yasuhiko Ohara, Mark K. Reagan, Katsunori Fujikura, Hiromi Watanabe, Katsuyoshi Michibayashi, Teruaki Ishii, Robert J. Stern, Ignacio Pujana, Fernando Martinez, Guillaume Girard, Julia Ribeiro, Maryjo Brounce, Naoaki Komori, and Masashi Kino
      PNAS February 21, 2012 109 (8) 2831-2835; https://doi.org/10.1073/pnas.1112005109
  • Evolution

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      “Evolution Canyon,” a potential microscale monitor of global warming across life
      Eviatar Nevo
      PNAS February 21, 2012 109 (8) 2960-2965; https://doi.org/10.1073/pnas.1120633109
    • You have access
      Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates
      Ruiqi Huang, Frank Hippauf, Diana Rohrbeck, Maria Haustein, Katrin Wenke, Janie Feike, Noah Sorrelle, Birgit Piechulla, and Todd J. Barkman
      PNAS February 21, 2012 109 (8) 2966-2971; https://doi.org/10.1073/pnas.1019605109
  • Genetics

    • You have access
      Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells
      Jason I. Herschkowitz, Wei Zhao, Mei Zhang, Jerry Usary, George Murrow, David Edwards, Jana Knezevic, Stephanie B. Greene, David Darr, Melissa A. Troester, Susan G. Hilsenbeck, Daniel Medina, Charles M. Perou, and Jeffrey M. Rosen
      PNAS February 21, 2012 109 (8) 2778-2783; https://doi.org/10.1073/pnas.1018862108
    • Open Access
      Human genetic variation altering anthrax toxin sensitivity
      Mikhail Martchenko, Sophie I. Candille, Hua Tang, and Stanley N. Cohen
      PNAS February 21, 2012 109 (8) 2972-2977; https://doi.org/10.1073/pnas.1121006109
    • You have access
      Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes
      Meaghan K. Russell, Mauro Longoni, Julie Wells, Faouzi I. Maalouf, Adam A. Tracy, Maria Loscertales, Kate G. Ackerman, Barbara R. Pober, Kasper Lage, Carol J. Bult, and Patricia K. Donahoe
      PNAS February 21, 2012 109 (8) 2978-2983; https://doi.org/10.1073/pnas.1121621109
    • You have access
      Exposure to anticancer drugs can result in transgenerational genomic instability in mice
      Colin D. Glen and Yuri E. Dubrova
      PNAS February 21, 2012 109 (8) 2984-2988; https://doi.org/10.1073/pnas.1119396109
    • Open Access
      Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
      Michael T. McCabe, Alan P. Graves, Gopinath Ganji, Elsie Diaz, Wendy S. Halsey, Yong Jiang, Kimberly N. Smitheman, Heidi M. Ott, Melissa B. Pappalardi, Kimberly E. Allen, Stephanie B. Chen, Anthony Della Pietra III, Edward Dul, Ashley M. Hughes, Seth A. Gilbert, Sara H. Thrall, Peter J. Tummino, Ryan G. Kruger, Martin Brandt, Benjamin Schwartz, and Caretha L. Creasy
      PNAS February 21, 2012 109 (8) 2989-2994; https://doi.org/10.1073/pnas.1116418109
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      Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria
      Irene Kamileri, Ismene Karakasilioti, Aria Sideri, Theodoros Kosteas, Antonis Tatarakis, Iannis Talianidis, and George A. Garinis
      PNAS February 21, 2012 109 (8) 2995-3000; https://doi.org/10.1073/pnas.1114941109
  • Immunology

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      Leukocyte composition of human breast cancer
      Brian Ruffell, Alfred Au, Hope S. Rugo, Laura J. Esserman, E. Shelley Hwang, and Lisa M. Coussens
      PNAS February 21, 2012 109 (8) 2796-2801; https://doi.org/10.1073/pnas.1104303108
    • You have access
      Significance analysis of xMap cytokine bead arrays
      Joong-Ho Won, Ofir Goldberger, Shai S. Shen-Orr, Mark M. Davis, and Richard A. Olshen
      PNAS February 21, 2012 109 (8) 2848-2853; https://doi.org/10.1073/pnas.1112599109
    • You have access
      IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
      Frank L. van de Veerdonk, Angela K. Stoeckman, Gouping Wu, Aaron N. Boeckermann, Tania Azam, Mihai G. Netea, Leo A. B. Joosten, Jos W. M. van der Meer, Ruyi Hao, Vassili Kalabokis, and Charles A. Dinarello
      PNAS February 21, 2012 109 (8) 3001-3005; https://doi.org/10.1073/pnas.1121534109
    • You have access
      Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells
      Giovanna Clavarino, Nuno Cláudio, Alexandre Dalet, Seigo Terawaki, Thérèse Couderc, Lionel Chasson, Maurizio Ceppi, Enrico K. Schmidt, Till Wenger, Marc Lecuit, Evelina Gatti, and Philippe Pierre
      PNAS February 21, 2012 109 (8) 3006-3011; https://doi.org/10.1073/pnas.1104491109
    • Open Access
      Plasmacytoid dendritic cells control T-cell response to chronic viral infection
      Luisa Cervantes-Barragan, Kanako L. Lewis, Sonja Firner, Volker Thiel, Stephanie Hugues, Walter Reith, Burkhard Ludewig, and Boris Reizis
      PNAS February 21, 2012 109 (8) 3012-3017; https://doi.org/10.1073/pnas.1117359109
  • Medical Sciences

    • You have access
      Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors
      Anindita Chakrabarty, Violeta Sánchez, María G. Kuba, Cammie Rinehart, and Carlos L. Arteaga
      PNAS February 21, 2012 109 (8) 2718-2723; https://doi.org/10.1073/pnas.1018001108
    • You have access
      Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen
      Ana M. Mendes-Pereira, David Sims, Tim Dexter, Kerry Fenwick, Ioannis Assiotis, Iwanka Kozarewa, Costas Mitsopoulos, Jarle Hakas, Marketa Zvelebil, Christopher J. Lord, and Alan Ashworth
      PNAS February 21, 2012 109 (8) 2730-2735; https://doi.org/10.1073/pnas.1018872108
    • You have access
      The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway
      Kideok Jin, Xiangjun Kong, Tariq Shah, Marie-France Penet, Flonne Wildes, Dennis C. Sgroi, Xiao-Jun Ma, Yi Huang, Anne Kallioniemi, Goran Landberg, Ivan Bieche, Xinyan Wu, Peter E. Lobie, Nancy E. Davidson, Zaver M. Bhujwalla, Tao Zhu, and Saraswati Sukumar
      PNAS February 21, 2012 109 (8) 2736-2741; https://doi.org/10.1073/pnas.1018859108
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      Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch
      James M. Haughian, Mauricio P. Pinto, J. Chuck Harrell, Brian S. Bliesner, Kristiina M. Joensuu, Wendy W. Dye, Carol A. Sartorius, Aik Choon Tan, Päivi Heikkilä, Charles M. Perou, and Kathryn B. Horwitz
      PNAS February 21, 2012 109 (8) 2742-2747; https://doi.org/10.1073/pnas.1106509108
    • You have access
      Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737
      Samantha R. Oakes, François Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E. Ritchie, Elena Takano, Teresa Ward, Stephen B. Fox, Daniele Generali, Gordon K. Smyth, Andreas Strasser, David C. S. Huang, Jane E. Visvader, and Geoffrey J. Lindeman
      PNAS February 21, 2012 109 (8) 2766-2771; https://doi.org/10.1073/pnas.1104778108
    • You have access
      Defining the cellular precursors to human breast cancer
      Patricia J. Keller, Lisa M. Arendt, Adam Skibinski, Tanya Logvinenko, Ina Klebba, Shumin Dong, Avi E. Smith, Aleix Prat, Charles M. Perou, Hannah Gilmore, Stuart Schnitt, Stephen P. Naber, Jonathan A. Garlick, and Charlotte Kuperwasser
      PNAS February 21, 2012 109 (8) 2772-2777; https://doi.org/10.1073/pnas.1017626108
    • You have access
      Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
      Sarah J. Conley, Elizabeth Gheordunescu, Pramod Kakarala, Bryan Newman, Hasan Korkaya, Amber N. Heath, Shawn G. Clouthier, and Max S. Wicha
      PNAS February 21, 2012 109 (8) 2784-2789; https://doi.org/10.1073/pnas.1018866109
    • You have access
      Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
      Vessela N. Kristensen, Charles J. Vaske, Josie Ursini-Siegel, Peter Van Loo, Silje H. Nordgard, Ravi Sachidanandam, Therese Sørlie, Fredrik Wärnberg, Vilde D. Haakensen, Åslaug Helland, Bjørn Naume, Charles M. Perou, David Haussler, Olga G. Troyanskaya, and Anne-Lise Børresen-Dale
      PNAS February 21, 2012 109 (8) 2802-2807; https://doi.org/10.1073/pnas.1108781108
    • You have access
      Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis
      Richard Marcotte, Harvey W. Smith, Virginie Sanguin-Gendreau, Rosalie V. McDonough, and William J. Muller
      PNAS February 21, 2012 109 (8) 2808-2813; https://doi.org/10.1073/pnas.1018861108
    • You have access
      Altered antisense-to-sense transcript ratios in breast cancer
      Reo Maruyama, Michail Shipitsin, Sibgat Choudhury, Zhenhua Wu, Alexei Protopopov, Jun Yao, Pang-Kuo Lo, Marina Bessarabova, Alex Ishkin, Yuri Nikolsky, X. Shirley Liu, Saraswati Sukumar, and Kornelia Polyak
      PNAS February 21, 2012 109 (8) 2820-2824; https://doi.org/10.1073/pnas.1010559107
    • You have access
      Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis
      Haizhong Feng, Bo Hu, Michael J. Jarzynka, Yanxin Li, Susan Keezer, Terrance G. Johns, Careen K. Tang, Ronald L. Hamilton, Kristiina Vuori, Ryo Nishikawa, Jann N. Sarkaria, Tim Fenton, Tao Cheng, Frank B. Furnari, Webster K. Cavenee, and Shi-Yuan Cheng
      PNAS February 21, 2012 109 (8) 3018-3023; https://doi.org/10.1073/pnas.1121457109
    • Open Access
      Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA
      Stefano Volinia, Marco Galasso, Maria Elena Sana, Timothy F. Wise, Jeff Palatini, Kay Huebner, and Carlo M. Croce
      PNAS February 21, 2012 109 (8) 3024-3029; https://doi.org/10.1073/pnas.1200010109
    • You have access
      Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β
      Chiara Gabbi, Xiaomu Kong, Hitoshi Suzuki, Hyun-Jin Kim, Min Gao, Xiao Jia, Hideo Ohnishi, Yoichi Ueta, Margaret Warner, Youfei Guan, and Jan-Åke Gustafsson
      PNAS February 21, 2012 109 (8) 3030-3034; https://doi.org/10.1073/pnas.1200588109
    • You have access
      Role of retroviral restriction factors in the interferon-α–mediated suppression of HIV-1 in vivo
      Satish K. Pillai, Mohamed Abdel-Mohsen, John Guatelli, Mark Skasko, Alexander Monto, Katsuya Fujimoto, Steven Yukl, Warner C. Greene, Helen Kovari, Andri Rauch, Jacques Fellay, Manuel Battegay, Bernard Hirschel, Andrea Witteck, Enos Bernasconi, Bruno Ledergerber, Huldrych F. Günthard, Joseph K. Wong, and the Swiss HIV Cohort Study
      PNAS February 21, 2012 109 (8) 3035-3040; https://doi.org/10.1073/pnas.1111573109
    • Open Access
      Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
      Nicholas J. Szerlip, Alicia Pedraza, Debyani Chakravarty, Mohammad Azim, Jeremy McGuire, Yuqiang Fang, Tatsuya Ozawa, Eric C. Holland, Jason T. Huse, Suresh Jhanwar, Margaret A. Leversha, Tom Mikkelsen, and Cameron W. Brennan
      PNAS February 21, 2012 109 (8) 3041-3046; https://doi.org/10.1073/pnas.1114033109
    • You have access
      Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling
      Caroline Bonnans, Maud Flacelière, Fanny Grillet, Christelle Dantec, Jean-Pierre Desvignes, Julie Pannequin, Dany Severac, Emeric Dubois, Frédéric Bibeau, Virginie Escriou, Philippe Crespy, Laurent Journot, Frédéric Hollande, and Dominique Joubert
      PNAS February 21, 2012 109 (8) 3047-3052; https://doi.org/10.1073/pnas.1109457109
    • You have access
      Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis
      Zehua Wang, Zemin Wang, Jianhui Guo, Yingchun Li, Jasmin H. Bavarva, Chiping Qian, M. Christiane Brahimi-Horn, Deyong Tan, and Wanguo Liu
      PNAS February 21, 2012 109 (8) 3053-3058; https://doi.org/10.1073/pnas.1113356109
  • Microbiology

    • Open Access
      Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus
      Sabiha Yasmin, Laura Alcazar-Fuoli, Mario Gründlinger, Thomas Puempel, Timothy Cairns, Michael Blatzer, Jordi F. Lopez, Joan O. Grimalt, Elaine Bignell, and Hubertus Haas
      PNAS February 21, 2012 109 (8) E497-E504; https://doi.org/10.1073/pnas.1106399108
    • You have access
      The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue
      Michael W. Harman, Star M. Dunham-Ems, Melissa J. Caimano, Alexia A. Belperron, Linda K. Bockenstedt, Henry C. Fu, Justin D. Radolf, and Charles W. Wolgemuth
      PNAS February 21, 2012 109 (8) 3059-3064; https://doi.org/10.1073/pnas.1114362109
    • Open Access
      Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011
      Yonatan H. Grad, Marc Lipsitch, Michael Feldgarden, Harindra M. Arachchi, Gustavo C. Cerqueira, Michael FitzGerald, Paul Godfrey, Brian J. Haas, Cheryl I. Murphy, Carsten Russ, Sean Sykes, Bruce J. Walker, Jennifer R. Wortman, Sarah Young, Qiandong Zeng, Amr Abouelleil, James Bochicchio, Sara Chauvin, Timothy DeSmet, Sharvari Gujja, Caryn McCowan, Anna Montmayeur, Scott Steelman, Jakob Frimodt-Møller, Andreas M. Petersen, Carsten Struve, Karen A. Krogfelt, Edouard Bingen, François-Xavier Weill, Eric S. Lander, Chad Nusbaum, Bruce W. Birren, Deborah T. Hung, and William P. Hanage
      PNAS February 21, 2012 109 (8) 3065-3070; https://doi.org/10.1073/pnas.1121491109

      See companion article:

      • Support for a bottleneck in the O104:H4 outbreaks
        - Dec 17, 2012
    • You have access
      Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection
      Laura J. Terry, Livia Vastag, Joshua D. Rabinowitz, and Thomas Shenk
      PNAS February 21, 2012 109 (8) 3071-3076; https://doi.org/10.1073/pnas.1200494109
    • You have access
      RNA virus microRNA that mimics a B-cell oncomiR
      • From the Cover
      Rodney P. Kincaid, James M. Burke, and Christopher S. Sullivan
      PNAS February 21, 2012 109 (8) 3077-3082; https://doi.org/10.1073/pnas.1116107109

      See companion article:

      • MicroRNA expression by an oncogenic retrovirus
        - Feb 02, 2012
    • You have access
      Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation
      Paul A. Price, Jianping Jin, and William E. Goldman
      PNAS February 21, 2012 109 (8) 3083-3088; https://doi.org/10.1073/pnas.1112729109
    • You have access
      Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention
      Margarita Magro, Vicente Mas, Keith Chappell, Mónica Vázquez, Olga Cano, Daniel Luque, María C. Terrón, José A. Melero, and Concepción Palomo
      PNAS February 21, 2012 109 (8) 3089-3094; https://doi.org/10.1073/pnas.1115941109
  • Neuroscience

    • You have access
      Phoneme and word recognition in the auditory ventral stream
      Iain DeWitt and Josef P. Rauschecker
      PNAS February 21, 2012 109 (8) E505-E514; https://doi.org/10.1073/pnas.1113427109
    • Open Access
      Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses
      Xuelin Lou, Fan Fan, Mirko Messa, Andrea Raimondi, Yumei Wu, Loren L. Looger, Shawn M. Ferguson, and Pietro De Camilli
      PNAS February 21, 2012 109 (8) E515-E523; https://doi.org/10.1073/pnas.1121626109
    • You have access
      A neurophysiological–metabolic model for burst suppression
      ShiNung Ching, Patrick L. Purdon, Sujith Vijayan, Nancy J. Kopell, and Emery N. Brown
      PNAS February 21, 2012 109 (8) 3095-3100; https://doi.org/10.1073/pnas.1121461109
    • You have access
      Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal
      • From the Cover
      Taryn E. Grieder, Olivier George, Huibing Tan, Susan R. George, Bernard Le Foll, Steven R. Laviolette, and Derek van der Kooy
      PNAS February 21, 2012 109 (8) 3101-3106; https://doi.org/10.1073/pnas.1114422109

      See companion article:

      • Shifting pharmacology of nicotine use and withdrawal: Breaking the cycle of drug abuse
        - Feb 03, 2012
    • Open Access
      Cortical topography of intracortical inhibition influences the speed of decision making
      Claudia Wilimzig, Patrick Ragert, and Hubert R. Dinse
      PNAS February 21, 2012 109 (8) 3107-3112; https://doi.org/10.1073/pnas.1114250109
    • You have access
      Highly neurotoxic monomeric α-helical prion protein
      Minghai Zhou, Gregory Ottenberg, Gian Franco Sferrazza, and Corinne Ida Lasmézas
      PNAS February 21, 2012 109 (8) 3113-3118; https://doi.org/10.1073/pnas.1118090109
    • Open Access
      Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum
      Rita Lopes, Nicole Verhey van Wijk, Guilherme Neves, and Vassilis Pachnis
      PNAS February 21, 2012 109 (8) 3119-3124; https://doi.org/10.1073/pnas.1109251109
    • Open Access
      MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function
      Brooke H. Miller, Zane Zeier, Li Xi, Thomas A. Lanz, Shibing Deng, Julia Strathmann, David Willoughby, Paul J. Kenny, John D. Elsworth, Matthew S. Lawrence, Robert H. Roth, Dieter Edbauer, Robin J. Kleiman, and Claes Wahlestedt
      PNAS February 21, 2012 109 (8) 3125-3130; https://doi.org/10.1073/pnas.1113793109
    • You have access
      Temporally-independent functional modes of spontaneous brain activity
      Stephen M. Smith, Karla L. Miller, Steen Moeller, Junqian Xu, Edward J. Auerbach, Mark W. Woolrich, Christian F. Beckmann, Mark Jenkinson, Jesper Andersson, Matthew F. Glasser, David C. Van Essen, David A. Feinberg, Essa S. Yacoub, and Kamil Ugurbil
      PNAS February 21, 2012 109 (8) 3131-3136; https://doi.org/10.1073/pnas.1121329109
  • Pharmacology

    • Open Access
      Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
      Jonathan E. Zuckerman, Chung Hang J. Choi, Han Han, and Mark E. Davis
      PNAS February 21, 2012 109 (8) 3137-3142; https://doi.org/10.1073/pnas.1200718109
    • You have access
      Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
      Wei Wei, Paul A. Dutchak, Xunde Wang, Xunshan Ding, Xueqian Wang, Angie L. Bookout, Regina Goetz, Moosa Mohammadi, Robert D. Gerard, Paul C. Dechow, David J. Mangelsdorf, Steven A. Kliewer, and Yihong Wan
      PNAS February 21, 2012 109 (8) 3143-3148; https://doi.org/10.1073/pnas.1200797109
    • You have access
      Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2
      Jianxiong Jiang, Thota Ganesh, Yuhong Du, Yi Quan, Geidy Serrano, Min Qui, Iris Speigel, Asheebo Rojas, Nadia Lelutiu, and Raymond Dingledine
      PNAS February 21, 2012 109 (8) 3149-3154; https://doi.org/10.1073/pnas.1120195109
  • Physiology

    • You have access
      Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
      George A. Kyriazis, Mangala M. Soundarapandian, and Björn Tyrberg
      PNAS February 21, 2012 109 (8) E524-E532; https://doi.org/10.1073/pnas.1115183109
    • Open Access
      Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
      Qi Wu, Benjamin B. Whiddon, and Richard D. Palmiter
      PNAS February 21, 2012 109 (8) 3155-3160; https://doi.org/10.1073/pnas.1120501109

      See companion article:

      • AgRP neurons: The foes of reproduction in leptin-deficient obese subjects
        - Feb 09, 2012
    • You have access
      Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels
      Byung-Chang Suh, Dong-Il Kim, Björn H. Falkenburger, and Bertil Hille
      PNAS February 21, 2012 109 (8) 3161-3166; https://doi.org/10.1073/pnas.1121434109
  • Plant Biology

    • Open Access
      Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor
      Joshua M. Gendron, José L. Pruneda-Paz, Colleen J. Doherty, Andrew M. Gross, S. Earl Kang, and Steve A. Kay
      PNAS February 21, 2012 109 (8) 3167-3172; https://doi.org/10.1073/pnas.1200355109
  • Population Biology

    • You have access
      Impact of cross-protective vaccines on epidemiological and evolutionary dynamics of influenza
      Nimalan Arinaminpathy, Oliver Ratmann, Katia Koelle, Suzanne L. Epstein, Graeme E. Price, Cecile Viboud, Mark A. Miller, and Bryan T. Grenfell
      PNAS February 21, 2012 109 (8) 3173-3177; https://doi.org/10.1073/pnas.1113342109
  • Psychological and Cognitive Sciences

    • You have access
      Optimal inference of sameness
      Ronald van den Berg, Michael Vogel, Krešimir Josić, and Wei Ji Ma
      PNAS February 21, 2012 109 (8) 3178-3183; https://doi.org/10.1073/pnas.1108790109
  • Systems Biology

    • You have access
      Subtype and pathway specific responses to anticancer compounds in breast cancer
      Laura M. Heiser, Anguraj Sadanandam, Wen-Lin Kuo, Stephen C. Benz, Theodore C. Goldstein, Sam Ng, William J. Gibb, Nicholas J. Wang, Safiyyah Ziyad, Frances Tong, Nora Bayani, Zhi Hu, Jessica I. Billig, Andrea Dueregger, Sophia Lewis, Lakshmi Jakkula, James E. Korkola, Steffen Durinck, François Pepin, Yinghui Guan, Elizabeth Purdom, Pierre Neuvial, Henrik Bengtsson, Kenneth W. Wood, Peter G. Smith, Lyubomir T. Vassilev, Bryan T. Hennessy, Joel Greshock, Kurtis E. Bachman, Mary Ann Hardwicke, John W. Park, Laurence J. Marton, Denise M. Wolf, Eric A. Collisson, Richard M. Neve, Gordon B. Mills, Terence P. Speed, Heidi S. Feiler, Richard F. Wooster, David Haussler, Joshua M. Stuart, Joe W. Gray, and Paul T. Spellman
      PNAS February 21, 2012 109 (8) 2724-2729; https://doi.org/10.1073/pnas.1018854108
    • You have access
      Integrated cross-species transcriptional network analysis of metastatic susceptibility
      Ying Hu, Gang Wu, Michael Rusch, Luanne Lukes, Kenneth H. Buetow, Jinghui Zhang, and Kent W. Hunter
      PNAS February 21, 2012 109 (8) 3184-3189; https://doi.org/10.1073/pnas.1117872109

Corrections

  • You have access
    Correction for Otten et al., Elucidating the mechanism of selective ion adsorption to the liquid water surface
    PNAS February 21, 2012 109 (8) 3190; https://doi.org/10.1073/pnas.1201349109
  • You have access
    Correction for Bonachela et al., Dynamic model of flexible phytoplankton nutrient uptake
    PNAS February 21, 2012 109 (8) 3190; https://doi.org/10.1073/pnas.1201165109
  • You have access
    Correction for Yang et al., Completely phased genome sequencing through chromosome sorting
    PNAS February 21, 2012 109 (8) 3190; https://doi.org/10.1073/pnas.1200309109
  • You have access
    Correction for Brown et al., Polar growth in the Alphaproteobacterial order Rhizobiales
    PNAS February 21, 2012 109 (8) 3190; https://doi.org/10.1073/pnas.1201353109
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Proceedings of the National Academy of Sciences: 109 (8)
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