Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells

    Kelly A. Holmes, Antoni Hurtado, Gordon D. Brown, Rosalind Launchbury, Caryn S. Ross-Innes, James Hadfield, Duncan T. Odom, and Jason S. Carroll

    PNAS February 21, 2012 109 (8) 2748-2753; https://doi.org/10.1073/pnas.1018863108

• Biochemistry

  • Open Access

    STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability

    Tuoping Luo, Kristina Masson, Jacob D. Jaffe, Whitney Silkworth, Nathan T. Ross, Christina A. Scherer, Claudia Scholl, Stefan Fröhling, Steven A. Carr, Andrew M. Stern, Stuart L. Schreiber, and Todd R. Golub

    PNAS February 21, 2012 109 (8) 2860-2865; https://doi.org/10.1073/pnas.1120589109
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    Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interaction

    Yue Jiao, Karsten Seeger, Aurelie Lautrette, Albane Gaubert, Florence Mousson, Raphael Guerois, Carl Mann, and Françoise Ochsenbein

    PNAS February 21, 2012 109 (8) 2866-2871; https://doi.org/10.1073/pnas.1106023109
  • Open Access

    Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan

    Stephen N. Floor, Mark S. Borja, and John D. Gross

    PNAS February 21, 2012 109 (8) 2872-2877; https://doi.org/10.1073/pnas.1113620109
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    Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly

    Giselle C. Yeo, Clair Baldock, Anne Tuukkanen, Manfred Roessle, Leanne B. Dyksterhuis, Steven G. Wise, Jacqueline Matthews, Suzanne M. Mithieux, and Anthony S. Weiss

    PNAS February 21, 2012 109 (8) 2878-2883; https://doi.org/10.1073/pnas.1111615108

• Biophysics and Computational Biology

  • Open Access

    Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling

    Nir Kalisman, Christopher M. Adams, and Michael Levitt

    PNAS February 21, 2012 109 (8) 2884-2889; https://doi.org/10.1073/pnas.1119472109
  • Open Access

    Modeling and design by hierarchical natural moves

    • From the Cover

    Adelene Y. L. Sim, Michael Levitt, and Peter Minary

    PNAS February 21, 2012 109 (8) 2890-2895; https://doi.org/10.1073/pnas.1119918109

    See companion article:

    • RNA modeling, naturally

      - Feb 21, 2012
  • Open Access

    Anomalous Brownian motion discloses viscoelasticity in the ear’s mechanoelectrical-transduction apparatus

    Andrei S. Kozlov, Daniel Andor-Ardó, and A. J. Hudspeth

    PNAS February 21, 2012 109 (8) 2896-2901; https://doi.org/10.1073/pnas.1121389109
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    Entropic origin of Mg²⁺-facilitated RNA folding

    Julie L. Fiore, Erik D. Holmstrom, and David J. Nesbitt

    PNAS February 21, 2012 109 (8) 2902-2907; https://doi.org/10.1073/pnas.1114859109
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    Structure of saposin A lipoprotein discs

    Konstantin Popovic, John Holyoake, Régis Pomès, and Gilbert G. Privé

    PNAS February 21, 2012 109 (8) 2908-2912; https://doi.org/10.1073/pnas.1115743109
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    Actin filament curvature biases branching direction

    Viviana I. Risca, Evan B. Wang, Ovijit Chaudhuri, Jia Jun Chia, Phillip L. Geissler, and Daniel A. Fletcher

    PNAS February 21, 2012 109 (8) 2913-2918; https://doi.org/10.1073/pnas.1114292109

    See companion article:

    • Actin bends over backward for directional branching

      - Feb 21, 2012
  • Open Access

    Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates

    Edward J. Botcherby, Christopher W. Smith, Michael M. Kohl, Delphine Débarre, Martin J. Booth, Rimas Juškaitis, Ole Paulsen, and Tony Wilson

    PNAS February 21, 2012 109 (8) 2919-2924; https://doi.org/10.1073/pnas.1111662109
  • Open Access

    DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg²⁺-mediated dynamic bending of gate-DNA

    Sanghwa Lee, Seung-Ryoung Jung, Kang Heo, Jo Ann W. Byl, Joseph E. Deweese, Neil Osheroff, and Sungchul Hohng

    PNAS February 21, 2012 109 (8) 2925-2930; https://doi.org/10.1073/pnas.1115704109

• Cell Biology

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    Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis

    Deanna M. Navaroli, Karl D. Bellvé, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera

    PNAS February 21, 2012 109 (8) E471-E480; https://doi.org/10.1073/pnas.1115495109
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    Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins

    Vasco Liberal, Hanna-Stina Martinsson-Ahlzén, Jennifer Liberal, Charles H. Spruck, Martin Widschwendter, Clare H. McGowan, and Steven I. Reed

    PNAS February 21, 2012 109 (8) 2754-2759; https://doi.org/10.1073/pnas.1102434108
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    Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses

    Naokazu Chiba, Valentine Comaills, Bunsyo Shiotani, Fumiyuki Takahashi, Toshiyuki Shimada, Ken Tajima, Daniel Winokur, Tetsu Hayashida, Henning Willers, Elena Brachtel, Maria d. M. Vivanco, Daniel A. Haber, Lee Zou, and Shyamala Maheswaran

    PNAS February 21, 2012 109 (8) 2760-2765; https://doi.org/10.1073/pnas.1018867108
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    Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression

    Xiaoli Zhang, Amy S. Farrell, Colin J. Daniel, Hugh Arnold, Charles Scanlan, Bryan J. Laraway, Mahnaz Janghorban, Lawrence Lum, Dexi Chen, Megan Troxell, and Rosalie Sears

    PNAS February 21, 2012 109 (8) 2790-2795; https://doi.org/10.1073/pnas.1100764108
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    Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators

    Philip Owens, Michael W. Pickup, Sergey V. Novitskiy, Anna Chytil, Agnieszka E. Gorska, Mary E. Aakre, James West, and Harold L. Moses

    PNAS February 21, 2012 109 (8) 2814-2819; https://doi.org/10.1073/pnas.1101139108
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    Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

    Lydia W. S. Finley, Jaewon Lee, Amanda Souza, Valérie Desquiret-Dumas, Kevin Bullock, Glenn C. Rowe, Vincent Procaccio, Clary B. Clish, Zoltan Arany, and Marcia C. Haigis

    PNAS February 21, 2012 109 (8) 2931-2936; https://doi.org/10.1073/pnas.1115813109
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    Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

    Shinji Tsutsumi, Mehdi Mollapour, Chrisostomos Prodromou, Chung-Tien Lee, Barry Panaretou, Soichiro Yoshida, Matthias P. Mayer, and Leonard M. Neckers

    PNAS February 21, 2012 109 (8) 2937-2942; https://doi.org/10.1073/pnas.1114414109
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    Hydrogen sulfide (H₂S) metabolism in mitochondria and its regulatory role in energy production

    Ming Fu, Weihua Zhang, Lingyun Wu, Guangdong Yang, Hongzhu Li, and Rui Wang

    PNAS February 21, 2012 109 (8) 2943-2948; https://doi.org/10.1073/pnas.1115634109

• Developmental Biology

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    Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development

    Pengpeng Ma, Hua Pan, Rusty L. Montgomery, Eric N. Olson, and Richard M. Schultz

    PNAS February 21, 2012 109 (8) E481-E489; https://doi.org/10.1073/pnas.1118403109
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    Control of target gene specificity during metamorphosis by the steroid response gene E93

    Xiaochun Mou, Dianne M. Duncan, Eric H. Baehrecke, and Ian Duncan

    PNAS February 21, 2012 109 (8) 2949-2954; https://doi.org/10.1073/pnas.1117559109
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    A Y-linked anti-Müllerian hormone duplication takes over a critical role in sex determination

    Ricardo S. Hattori, Yu Murai, Miho Oura, Shuji Masuda, Sullip K. Majhi, Takashi Sakamoto, Juan I. Fernandino, Gustavo M. Somoza, Masashi Yokota, and Carlos A. Strüssmann

    PNAS February 21, 2012 109 (8) 2955-2959; https://doi.org/10.1073/pnas.1018392109

• Ecology

  • Open Access

    Unusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpecker

    Dorit Eliyahu, Satoshi Nojima, Richard G. Santangelo, Shannon Carpenter, Francis X. Webster, David J. Kiemle, Cesar Gemeno, Walter S. Leal, and Coby Schal

    PNAS February 21, 2012 109 (8) E490-E496; https://doi.org/10.1073/pnas.1111748109
  • Open Access

    A serpentinite-hosted ecosystem in the Southern Mariana Forearc

    Yasuhiko Ohara, Mark K. Reagan, Katsunori Fujikura, Hiromi Watanabe, Katsuyoshi Michibayashi, Teruaki Ishii, Robert J. Stern, Ignacio Pujana, Fernando Martinez, Guillaume Girard, Julia Ribeiro, Maryjo Brounce, Naoaki Komori, and Masashi Kino

    PNAS February 21, 2012 109 (8) 2831-2835; https://doi.org/10.1073/pnas.1112005109

• Evolution

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    “Evolution Canyon,” a potential microscale monitor of global warming across life

    Eviatar Nevo

    PNAS February 21, 2012 109 (8) 2960-2965; https://doi.org/10.1073/pnas.1120633109
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    Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates

    Ruiqi Huang, Frank Hippauf, Diana Rohrbeck, Maria Haustein, Katrin Wenke, Janie Feike, Noah Sorrelle, Birgit Piechulla, and Todd J. Barkman

    PNAS February 21, 2012 109 (8) 2966-2971; https://doi.org/10.1073/pnas.1019605109

• Genetics

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    Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells

    Jason I. Herschkowitz, Wei Zhao, Mei Zhang, Jerry Usary, George Murrow, David Edwards, Jana Knezevic, Stephanie B. Greene, David Darr, Melissa A. Troester, Susan G. Hilsenbeck, Daniel Medina, Charles M. Perou, and Jeffrey M. Rosen

    PNAS February 21, 2012 109 (8) 2778-2783; https://doi.org/10.1073/pnas.1018862108
  • Open Access

    Human genetic variation altering anthrax toxin sensitivity

    Mikhail Martchenko, Sophie I. Candille, Hua Tang, and Stanley N. Cohen

    PNAS February 21, 2012 109 (8) 2972-2977; https://doi.org/10.1073/pnas.1121006109
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    Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes

    Meaghan K. Russell, Mauro Longoni, Julie Wells, Faouzi I. Maalouf, Adam A. Tracy, Maria Loscertales, Kate G. Ackerman, Barbara R. Pober, Kasper Lage, Carol J. Bult, and Patricia K. Donahoe

    PNAS February 21, 2012 109 (8) 2978-2983; https://doi.org/10.1073/pnas.1121621109
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    Exposure to anticancer drugs can result in transgenerational genomic instability in mice

    Colin D. Glen and Yuri E. Dubrova

    PNAS February 21, 2012 109 (8) 2984-2988; https://doi.org/10.1073/pnas.1119396109
  • Open Access

    Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

    Michael T. McCabe, Alan P. Graves, Gopinath Ganji, Elsie Diaz, Wendy S. Halsey, Yong Jiang, Kimberly N. Smitheman, Heidi M. Ott, Melissa B. Pappalardi, Kimberly E. Allen, Stephanie B. Chen, Anthony Della Pietra III, Edward Dul, Ashley M. Hughes, Seth A. Gilbert, Sara H. Thrall, Peter J. Tummino, Ryan G. Kruger, Martin Brandt, Benjamin Schwartz, and Caretha L. Creasy

    PNAS February 21, 2012 109 (8) 2989-2994; https://doi.org/10.1073/pnas.1116418109
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    Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria

    Irene Kamileri, Ismene Karakasilioti, Aria Sideri, Theodoros Kosteas, Antonis Tatarakis, Iannis Talianidis, and George A. Garinis

    PNAS February 21, 2012 109 (8) 2995-3000; https://doi.org/10.1073/pnas.1114941109

• Immunology

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    Leukocyte composition of human breast cancer

    Brian Ruffell, Alfred Au, Hope S. Rugo, Laura J. Esserman, E. Shelley Hwang, and Lisa M. Coussens

    PNAS February 21, 2012 109 (8) 2796-2801; https://doi.org/10.1073/pnas.1104303108
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    Significance analysis of xMap cytokine bead arrays

    Joong-Ho Won, Ofir Goldberger, Shai S. Shen-Orr, Mark M. Davis, and Richard A. Olshen

    PNAS February 21, 2012 109 (8) 2848-2853; https://doi.org/10.1073/pnas.1112599109
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    IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

    Frank L. van de Veerdonk, Angela K. Stoeckman, Gouping Wu, Aaron N. Boeckermann, Tania Azam, Mihai G. Netea, Leo A. B. Joosten, Jos W. M. van der Meer, Ruyi Hao, Vassili Kalabokis, and Charles A. Dinarello

    PNAS February 21, 2012 109 (8) 3001-3005; https://doi.org/10.1073/pnas.1121534109
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    Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells

    Giovanna Clavarino, Nuno Cláudio, Alexandre Dalet, Seigo Terawaki, Thérèse Couderc, Lionel Chasson, Maurizio Ceppi, Enrico K. Schmidt, Till Wenger, Marc Lecuit, Evelina Gatti, and Philippe Pierre

    PNAS February 21, 2012 109 (8) 3006-3011; https://doi.org/10.1073/pnas.1104491109
  • Open Access

    Plasmacytoid dendritic cells control T-cell response to chronic viral infection

    Luisa Cervantes-Barragan, Kanako L. Lewis, Sonja Firner, Volker Thiel, Stephanie Hugues, Walter Reith, Burkhard Ludewig, and Boris Reizis

    PNAS February 21, 2012 109 (8) 3012-3017; https://doi.org/10.1073/pnas.1117359109

• Medical Sciences

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    Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors

    Anindita Chakrabarty, Violeta Sánchez, María G. Kuba, Cammie Rinehart, and Carlos L. Arteaga

    PNAS February 21, 2012 109 (8) 2718-2723; https://doi.org/10.1073/pnas.1018001108
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    Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen

    Ana M. Mendes-Pereira, David Sims, Tim Dexter, Kerry Fenwick, Ioannis Assiotis, Iwanka Kozarewa, Costas Mitsopoulos, Jarle Hakas, Marketa Zvelebil, Christopher J. Lord, and Alan Ashworth

    PNAS February 21, 2012 109 (8) 2730-2735; https://doi.org/10.1073/pnas.1018872108
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    The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway

    Kideok Jin, Xiangjun Kong, Tariq Shah, Marie-France Penet, Flonne Wildes, Dennis C. Sgroi, Xiao-Jun Ma, Yi Huang, Anne Kallioniemi, Goran Landberg, Ivan Bieche, Xinyan Wu, Peter E. Lobie, Nancy E. Davidson, Zaver M. Bhujwalla, Tao Zhu, and Saraswati Sukumar

    PNAS February 21, 2012 109 (8) 2736-2741; https://doi.org/10.1073/pnas.1018859108
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    Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

    James M. Haughian, Mauricio P. Pinto, J. Chuck Harrell, Brian S. Bliesner, Kristiina M. Joensuu, Wendy W. Dye, Carol A. Sartorius, Aik Choon Tan, Päivi Heikkilä, Charles M. Perou, and Kathryn B. Horwitz

    PNAS February 21, 2012 109 (8) 2742-2747; https://doi.org/10.1073/pnas.1106509108
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    Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

    Samantha R. Oakes, François Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E. Ritchie, Elena Takano, Teresa Ward, Stephen B. Fox, Daniele Generali, Gordon K. Smyth, Andreas Strasser, David C. S. Huang, Jane E. Visvader, and Geoffrey J. Lindeman

    PNAS February 21, 2012 109 (8) 2766-2771; https://doi.org/10.1073/pnas.1104778108
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    Defining the cellular precursors to human breast cancer

    Patricia J. Keller, Lisa M. Arendt, Adam Skibinski, Tanya Logvinenko, Ina Klebba, Shumin Dong, Avi E. Smith, Aleix Prat, Charles M. Perou, Hannah Gilmore, Stuart Schnitt, Stephen P. Naber, Jonathan A. Garlick, and Charlotte Kuperwasser

    PNAS February 21, 2012 109 (8) 2772-2777; https://doi.org/10.1073/pnas.1017626108
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    Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

    Sarah J. Conley, Elizabeth Gheordunescu, Pramod Kakarala, Bryan Newman, Hasan Korkaya, Amber N. Heath, Shawn G. Clouthier, and Max S. Wicha

    PNAS February 21, 2012 109 (8) 2784-2789; https://doi.org/10.1073/pnas.1018866109
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    Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling

    Vessela N. Kristensen, Charles J. Vaske, Josie Ursini-Siegel, Peter Van Loo, Silje H. Nordgard, Ravi Sachidanandam, Therese Sørlie, Fredrik Wärnberg, Vilde D. Haakensen, Åslaug Helland, Bjørn Naume, Charles M. Perou, David Haussler, Olga G. Troyanskaya, and Anne-Lise Børresen-Dale

    PNAS February 21, 2012 109 (8) 2802-2807; https://doi.org/10.1073/pnas.1108781108
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    Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis

    Richard Marcotte, Harvey W. Smith, Virginie Sanguin-Gendreau, Rosalie V. McDonough, and William J. Muller

    PNAS February 21, 2012 109 (8) 2808-2813; https://doi.org/10.1073/pnas.1018861108
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    Altered antisense-to-sense transcript ratios in breast cancer

    Reo Maruyama, Michail Shipitsin, Sibgat Choudhury, Zhenhua Wu, Alexei Protopopov, Jun Yao, Pang-Kuo Lo, Marina Bessarabova, Alex Ishkin, Yuri Nikolsky, X. Shirley Liu, Saraswati Sukumar, and Kornelia Polyak

    PNAS February 21, 2012 109 (8) 2820-2824; https://doi.org/10.1073/pnas.1010559107
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    Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

    Haizhong Feng, Bo Hu, Michael J. Jarzynka, Yanxin Li, Susan Keezer, Terrance G. Johns, Careen K. Tang, Ronald L. Hamilton, Kristiina Vuori, Ryo Nishikawa, Jann N. Sarkaria, Tim Fenton, Tao Cheng, Frank B. Furnari, Webster K. Cavenee, and Shi-Yuan Cheng

    PNAS February 21, 2012 109 (8) 3018-3023; https://doi.org/10.1073/pnas.1121457109
  • Open Access

    Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA

    Stefano Volinia, Marco Galasso, Maria Elena Sana, Timothy F. Wise, Jeff Palatini, Kay Huebner, and Carlo M. Croce

    PNAS February 21, 2012 109 (8) 3024-3029; https://doi.org/10.1073/pnas.1200010109
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    Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β

    Chiara Gabbi, Xiaomu Kong, Hitoshi Suzuki, Hyun-Jin Kim, Min Gao, Xiao Jia, Hideo Ohnishi, Yoichi Ueta, Margaret Warner, Youfei Guan, and Jan-Åke Gustafsson

    PNAS February 21, 2012 109 (8) 3030-3034; https://doi.org/10.1073/pnas.1200588109
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    Role of retroviral restriction factors in the interferon-α–mediated suppression of HIV-1 in vivo

    Satish K. Pillai, Mohamed Abdel-Mohsen, John Guatelli, Mark Skasko, Alexander Monto, Katsuya Fujimoto, Steven Yukl, Warner C. Greene, Helen Kovari, Andri Rauch, Jacques Fellay, Manuel Battegay, Bernard Hirschel, Andrea Witteck, Enos Bernasconi, Bruno Ledergerber, Huldrych F. Günthard, Joseph K. Wong, and the Swiss HIV Cohort Study

    PNAS February 21, 2012 109 (8) 3035-3040; https://doi.org/10.1073/pnas.1111573109
  • Open Access

    Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

    Nicholas J. Szerlip, Alicia Pedraza, Debyani Chakravarty, Mohammad Azim, Jeremy McGuire, Yuqiang Fang, Tatsuya Ozawa, Eric C. Holland, Jason T. Huse, Suresh Jhanwar, Margaret A. Leversha, Tom Mikkelsen, and Cameron W. Brennan

    PNAS February 21, 2012 109 (8) 3041-3046; https://doi.org/10.1073/pnas.1114033109
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    Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling

    Caroline Bonnans, Maud Flacelière, Fanny Grillet, Christelle Dantec, Jean-Pierre Desvignes, Julie Pannequin, Dany Severac, Emeric Dubois, Frédéric Bibeau, Virginie Escriou, Philippe Crespy, Laurent Journot, Frédéric Hollande, and Dominique Joubert

    PNAS February 21, 2012 109 (8) 3047-3052; https://doi.org/10.1073/pnas.1109457109
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    Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis

    Zehua Wang, Zemin Wang, Jianhui Guo, Yingchun Li, Jasmin H. Bavarva, Chiping Qian, M. Christiane Brahimi-Horn, Deyong Tan, and Wanguo Liu

    PNAS February 21, 2012 109 (8) 3053-3058; https://doi.org/10.1073/pnas.1113356109

• Microbiology

  • Open Access

    Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus

    Sabiha Yasmin, Laura Alcazar-Fuoli, Mario Gründlinger, Thomas Puempel, Timothy Cairns, Michael Blatzer, Jordi F. Lopez, Joan O. Grimalt, Elaine Bignell, and Hubertus Haas

    PNAS February 21, 2012 109 (8) E497-E504; https://doi.org/10.1073/pnas.1106399108
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    The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue

    Michael W. Harman, Star M. Dunham-Ems, Melissa J. Caimano, Alexia A. Belperron, Linda K. Bockenstedt, Henry C. Fu, Justin D. Radolf, and Charles W. Wolgemuth

    PNAS February 21, 2012 109 (8) 3059-3064; https://doi.org/10.1073/pnas.1114362109
  • Open Access

    Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011

    Yonatan H. Grad, Marc Lipsitch, Michael Feldgarden, Harindra M. Arachchi, Gustavo C. Cerqueira, Michael FitzGerald, Paul Godfrey, Brian J. Haas, Cheryl I. Murphy, Carsten Russ, Sean Sykes, Bruce J. Walker, Jennifer R. Wortman, Sarah Young, Qiandong Zeng, Amr Abouelleil, James Bochicchio, Sara Chauvin, Timothy DeSmet, Sharvari Gujja, Caryn McCowan, Anna Montmayeur, Scott Steelman, Jakob Frimodt-Møller, Andreas M. Petersen, Carsten Struve, Karen A. Krogfelt, Edouard Bingen, François-Xavier Weill, Eric S. Lander, Chad Nusbaum, Bruce W. Birren, Deborah T. Hung, and William P. Hanage

    PNAS February 21, 2012 109 (8) 3065-3070; https://doi.org/10.1073/pnas.1121491109

    See companion article:

    • Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany

      - Dec 26, 2012
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    Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection

    Laura J. Terry, Livia Vastag, Joshua D. Rabinowitz, and Thomas Shenk

    PNAS February 21, 2012 109 (8) 3071-3076; https://doi.org/10.1073/pnas.1200494109
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    RNA virus microRNA that mimics a B-cell oncomiR

    • From the Cover

    Rodney P. Kincaid, James M. Burke, and Christopher S. Sullivan

    PNAS February 21, 2012 109 (8) 3077-3082; https://doi.org/10.1073/pnas.1116107109

    See companion article:

    • MicroRNA expression by an oncogenic retrovirus

      - Feb 21, 2012
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    Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation

    Paul A. Price, Jianping Jin, and William E. Goldman

    PNAS February 21, 2012 109 (8) 3083-3088; https://doi.org/10.1073/pnas.1112729109
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    Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention

    Margarita Magro, Vicente Mas, Keith Chappell, Mónica Vázquez, Olga Cano, Daniel Luque, María C. Terrón, José A. Melero, and Concepción Palomo

    PNAS February 21, 2012 109 (8) 3089-3094; https://doi.org/10.1073/pnas.1115941109

• Neuroscience

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    Phoneme and word recognition in the auditory ventral stream

    Iain DeWitt and Josef P. Rauschecker

    PNAS February 21, 2012 109 (8) E505-E514; https://doi.org/10.1073/pnas.1113427109
  • Open Access

    Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses

    Xuelin Lou, Fan Fan, Mirko Messa, Andrea Raimondi, Yumei Wu, Loren L. Looger, Shawn M. Ferguson, and Pietro De Camilli

    PNAS February 21, 2012 109 (8) E515-E523; https://doi.org/10.1073/pnas.1121626109
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    A neurophysiological–metabolic model for burst suppression

    ShiNung Ching, Patrick L. Purdon, Sujith Vijayan, Nancy J. Kopell, and Emery N. Brown

    PNAS February 21, 2012 109 (8) 3095-3100; https://doi.org/10.1073/pnas.1121461109
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    Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal

    • From the Cover

    Taryn E. Grieder, Olivier George, Huibing Tan, Susan R. George, Bernard Le Foll, Steven R. Laviolette, and Derek van der Kooy

    PNAS February 21, 2012 109 (8) 3101-3106; https://doi.org/10.1073/pnas.1114422109

    See companion article:

    • Shifting pharmacology of nicotine use and withdrawal: Breaking the cycle of drug abuse

      - Feb 21, 2012
  • Open Access

    Cortical topography of intracortical inhibition influences the speed of decision making

    Claudia Wilimzig, Patrick Ragert, and Hubert R. Dinse

    PNAS February 21, 2012 109 (8) 3107-3112; https://doi.org/10.1073/pnas.1114250109
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    Highly neurotoxic monomeric α-helical prion protein

    Minghai Zhou, Gregory Ottenberg, Gian Franco Sferrazza, and Corinne Ida Lasmézas

    PNAS February 21, 2012 109 (8) 3113-3118; https://doi.org/10.1073/pnas.1118090109
  • Open Access

    Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum

    Rita Lopes, Nicole Verhey van Wijk, Guilherme Neves, and Vassilis Pachnis

    PNAS February 21, 2012 109 (8) 3119-3124; https://doi.org/10.1073/pnas.1109251109
  • Open Access

    MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function

    Brooke H. Miller, Zane Zeier, Li Xi, Thomas A. Lanz, Shibing Deng, Julia Strathmann, David Willoughby, Paul J. Kenny, John D. Elsworth, Matthew S. Lawrence, Robert H. Roth, Dieter Edbauer, Robin J. Kleiman, and Claes Wahlestedt

    PNAS February 21, 2012 109 (8) 3125-3130; https://doi.org/10.1073/pnas.1113793109
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    Temporally-independent functional modes of spontaneous brain activity

    Stephen M. Smith, Karla L. Miller, Steen Moeller, Junqian Xu, Edward J. Auerbach, Mark W. Woolrich, Christian F. Beckmann, Mark Jenkinson, Jesper Andersson, Matthew F. Glasser, David C. Van Essen, David A. Feinberg, Essa S. Yacoub, and Kamil Ugurbil

    PNAS February 21, 2012 109 (8) 3131-3136; https://doi.org/10.1073/pnas.1121329109

• Pharmacology

  • Open Access

    Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane

    Jonathan E. Zuckerman, Chung Hang J. Choi, Han Han, and Mark E. Davis

    PNAS February 21, 2012 109 (8) 3137-3142; https://doi.org/10.1073/pnas.1200718109
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    Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

    Wei Wei, Paul A. Dutchak, Xunde Wang, Xunshan Ding, Xueqian Wang, Angie L. Bookout, Regina Goetz, Moosa Mohammadi, Robert D. Gerard, Paul C. Dechow, David J. Mangelsdorf, Steven A. Kliewer, and Yihong Wan

    PNAS February 21, 2012 109 (8) 3143-3148; https://doi.org/10.1073/pnas.1200797109
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    Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

    Jianxiong Jiang, Thota Ganesh, Yuhong Du, Yi Quan, Geidy Serrano, Min Qui, Iris Speigel, Asheebo Rojas, Nadia Lelutiu, and Raymond Dingledine

    PNAS February 21, 2012 109 (8) 3149-3154; https://doi.org/10.1073/pnas.1120195109

• Physiology

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    Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion

    George A. Kyriazis, Mangala M. Soundarapandian, and Björn Tyrberg

    PNAS February 21, 2012 109 (8) E524-E532; https://doi.org/10.1073/pnas.1115183109
  • Open Access

    Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility

    Qi Wu, Benjamin B. Whiddon, and Richard D. Palmiter

    PNAS February 21, 2012 109 (8) 3155-3160; https://doi.org/10.1073/pnas.1120501109

    See companion article:

    • AgRP neurons: The foes of reproduction in leptin-deficient obese subjects

      - Feb 21, 2012
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    Membrane-localized β-subunits alter the PIP₂ regulation of high-voltage activated Ca²⁺ channels

    Byung-Chang Suh, Dong-Il Kim, Björn H. Falkenburger, and Bertil Hille

    PNAS February 21, 2012 109 (8) 3161-3166; https://doi.org/10.1073/pnas.1121434109

• Plant Biology

  • Open Access

    Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor

    Joshua M. Gendron, José L. Pruneda-Paz, Colleen J. Doherty, Andrew M. Gross, S. Earl Kang, and Steve A. Kay

    PNAS February 21, 2012 109 (8) 3167-3172; https://doi.org/10.1073/pnas.1200355109

• Population Biology

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    Impact of cross-protective vaccines on epidemiological and evolutionary dynamics of influenza

    Nimalan Arinaminpathy, Oliver Ratmann, Katia Koelle, Suzanne L. Epstein, Graeme E. Price, Cecile Viboud, Mark A. Miller, and Bryan T. Grenfell

    PNAS February 21, 2012 109 (8) 3173-3177; https://doi.org/10.1073/pnas.1113342109

• Psychological and Cognitive Sciences

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    Optimal inference of sameness

    Ronald van den Berg, Michael Vogel, Krešimir Josić, and Wei Ji Ma

    PNAS February 21, 2012 109 (8) 3178-3183; https://doi.org/10.1073/pnas.1108790109

• Systems Biology

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    Subtype and pathway specific responses to anticancer compounds in breast cancer

    Laura M. Heiser, Anguraj Sadanandam, Wen-Lin Kuo, Stephen C. Benz, Theodore C. Goldstein, Sam Ng, William J. Gibb, Nicholas J. Wang, Safiyyah Ziyad, Frances Tong, Nora Bayani, Zhi Hu, Jessica I. Billig, Andrea Dueregger, Sophia Lewis, Lakshmi Jakkula, James E. Korkola, Steffen Durinck, François Pepin, Yinghui Guan, Elizabeth Purdom, Pierre Neuvial, Henrik Bengtsson, Kenneth W. Wood, Peter G. Smith, Lyubomir T. Vassilev, Bryan T. Hennessy, Joel Greshock, Kurtis E. Bachman, Mary Ann Hardwicke, John W. Park, Laurence J. Marton, Denise M. Wolf, Eric A. Collisson, Richard M. Neve, Gordon B. Mills, Terence P. Speed, Heidi S. Feiler, Richard F. Wooster, David Haussler, Joshua M. Stuart, Joe W. Gray, and Paul T. Spellman

    PNAS February 21, 2012 109 (8) 2724-2729; https://doi.org/10.1073/pnas.1018854108
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    Integrated cross-species transcriptional network analysis of metastatic susceptibility

    Ying Hu, Gang Wu, Michael Rusch, Luanne Lukes, Kenneth H. Buetow, Jinghui Zhang, and Kent W. Hunter

    PNAS February 21, 2012 109 (8) 3184-3189; https://doi.org/10.1073/pnas.1117872109