Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types

Jason L. Kubinak, James S. Ruff, Cornelius Whitney Hyzer, Patricia R. Slev, and Wayne K. Potts
PNAS February 28, 2012 109 (9) 3422-3427; https://doi.org/10.1073/pnas.1112633109

  1. Edited by Michael Lynch, Indiana University, Bloomington, IN, and approved January 17, 2012 (received for review August 4, 2011)

Online Impact

Article Information

vol. 109 no. 9 3422-3427
DOI: 
https://doi.org/10.1073/pnas.1112633109
PubMed: 
22323587
Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue February 28, 2012.
  • Published first February 7, 2012.

Author Information

  1. Jason L. Kubinaka,1,
  2. James S. Ruffa,
  3. Cornelius Whitney Hyzera,
  4. Patricia R. Slevb, and
  5. Wayne K. Pottsa
  1. aDepartment of Biology and
  2. bDepartment of Pathology, University of Utah, Salt Lake City, UT 84112

  1. Edited by Michael Lynch, Indiana University, Bloomington, IN, and approved January 17, 2012 (received for review August 4, 2011)

Footnotes

  • ↵1To whom correspondence should be addressed. E-mail: jason.kubinak{at}path.utah.edu.

  • Author contributions: J.L.K., J.S.R., P.R.S., and W.K.P. designed research; J.L.K. and C.W.H. performed research; J.L.K. and W.K.P. analyzed data; and J.L.K. and W.K.P. wrote the manuscript.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1112633109/-/DCSupplemental.

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Feb 2012445474559
Mar 20123232130365
Apr 20123762454
May 20122474151
Jun 20121403231
Jul 20121081015
Aug 20121151931
Sep 2012811625
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Total 201290144091214
Jan 2013802032
Feb 2013782123
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Apr 2013941723
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Jul 201360818
Aug 2013531117
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Oct 2013651526
Nov 20131072825
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Total 2013802163289
Jan 2014601915
Feb 2014571316
Mar 201443167
Apr 2014682220
May 2014352411
Jun 2014371910
Jul 201433147
Aug 20145095
Sep 2014601811
Oct 2014541310
Nov 201452179
Dec 201458204
Total 2014607204125
Jan 201557813
Feb 201537512
Mar 201553325
Apr 2015401120
May 201533413
Jun 2015462014
Jul 2015431288
Aug 201525106
Sep 2015601111
Oct 20152936
Nov 2015851117
Dec 201553910
Total 2015561252135
Jan 201649410
Feb 201634169
Mar 2016371210
Apr 20163632
May 20164368
Jun 2016331310
Jul 201635511
Aug 20164164
Sep 20164288
Oct 20166444
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Total 201650915395
Jan 20174299
Feb 20173294
Mar 201733811
Apr 201727143
May 20173193
Jun 201730910
Jul 201732148
Aug 20172886
Sep 201740139
Oct 201744913
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Dec 20172664
Total 201739512189
Jan 201831164
Feb 201832286
Mar 2018353010
Apr 2018503820
May 201829474
Jun 201843305
Jul 201815174
Aug 201828195
Sep 201830338
Oct 20185269
Nov 201872310
Dec 20183196
Total 201830832691
Total1219616282038
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Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types
Jason L. Kubinak, James S. Ruff, Cornelius Whitney Hyzer, Patricia R. Slev, Wayne K. Potts
Proceedings of the National Academy of Sciences Feb 2012, 109 (9) 3422-3427; DOI: 10.1073/pnas.1112633109
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