Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types | PNAS

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Edited by Michael Lynch, Indiana University, Bloomington, IN, and approved January 17, 2012 (received for review August 4, 2011)

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Article Information

vol. 109 no. 9 3422-3427

DOI:

https://doi.org/10.1073/pnas.1112633109

PubMed:

Published By:

National Academy of Sciences

Print ISSN:

Online ISSN:

History:

Published in issue February 28, 2012.
Published first February 7, 2012.

Author Information

Jason L. Kubinak^a,¹,
James S. Ruff^a,
Cornelius Whitney Hyzer^a,
Patricia R. Slev^b, and
Wayne K. Potts^a

^aDepartment of Biology and
^bDepartment of Pathology, University of Utah, Salt Lake City, UT 84112

Edited by Michael Lynch, Indiana University, Bloomington, IN, and approved January 17, 2012 (received for review August 4, 2011)

Footnotes

↵¹To whom correspondence should be addressed. E-mail: jason.kubinak{at}path.utah.edu.

Author contributions: J.L.K., J.S.R., P.R.S., and W.K.P. designed research; J.L.K. and C.W.H. performed research; J.L.K. and W.K.P. analyzed data; and J.L.K. and W.K.P. wrote the manuscript.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1112633109/-/DCSupplemental.

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Article usage

Article usage: February 2012 to December 2019

	Abstract	Full	Pdf
Feb 2012	4454	74	559
Mar 2012	3232	130	365
Apr 2012	376	24	54
May 2012	247	41	51
Jun 2012	140	32	31
Jul 2012	108	10	15
Aug 2012	115	19	31
Sep 2012	81	16	25
Oct 2012	89	16	26
Nov 2012	88	31	34
Dec 2012	84	16	23
Total 2012	9014	409	1214
Jan 2013	80	20	32
Feb 2013	78	21	23
Mar 2013	72	23	46
Apr 2013	94	17	23
May 2013	52	9	29
Jun 2013	41	3	14
Jul 2013	60	8	18
Aug 2013	53	11	17
Sep 2013	48	4	26
Oct 2013	65	15	26
Nov 2013	107	28	25
Dec 2013	52	4	10
Total 2013	802	163	289
Jan 2014	60	19	15
Feb 2014	57	13	16
Mar 2014	43	16	7
Apr 2014	68	22	20
May 2014	35	24	11
Jun 2014	37	19	10
Jul 2014	33	14	7
Aug 2014	50	9	5
Sep 2014	60	18	11
Oct 2014	54	13	10
Nov 2014	52	17	9
Dec 2014	58	20	4
Total 2014	607	204	125
Jan 2015	57	8	13
Feb 2015	37	5	12
Mar 2015	53	32	5
Apr 2015	40	11	20
May 2015	33	4	13
Jun 2015	46	20	14
Jul 2015	43	128	8
Aug 2015	25	10	6
Sep 2015	60	11	11
Oct 2015	29	3	6
Nov 2015	85	11	17
Dec 2015	53	9	10
Total 2015	561	252	135
Jan 2016	49	4	10
Feb 2016	34	16	9
Mar 2016	37	12	10
Apr 2016	36	3	2
May 2016	43	6	8
Jun 2016	33	13	10
Jul 2016	35	5	11
Aug 2016	41	6	4
Sep 2016	42	8	8
Oct 2016	64	4	4
Nov 2016	52	65	7
Dec 2016	43	11	12
Total 2016	509	153	95
Jan 2017	42	9	9
Feb 2017	32	9	4
Mar 2017	33	8	11
Apr 2017	27	14	3
May 2017	31	9	3
Jun 2017	30	9	10
Jul 2017	32	14	8
Aug 2017	28	8	6
Sep 2017	40	13	9
Oct 2017	44	9	13
Nov 2017	30	13	9
Dec 2017	26	6	4
Total 2017	395	121	89
Jan 2018	31	16	4
Feb 2018	32	28	6
Mar 2018	35	30	10
Apr 2018	50	38	20
May 2018	29	47	4
Jun 2018	43	30	5
Jul 2018	15	17	4
Aug 2018	28	19	5
Sep 2018	30	33	8
Oct 2018	5	26	9
Nov 2018	7	23	10
Dec 2018	3	29	11
Total 2018	308	336	96
Jan 2019	3	15	5
Feb 2019	4	20	5
Mar 2019	5	14	8
Apr 2019	8	20	6
May 2019	12	11	11
Jun 2019	4	16	8
Jul 2019	1	22	12
Aug 2019	11	21	6
Sep 2019	2	44	11
Oct 2019	8	50	13
Nov 2019	7	20	7
Dec 2019	2	5	2
Total 2019	67	258	94
Total	12263	1896	2137

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Article Classifications

Biological Sciences
Evolution

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