Better explicating the strengths and shortcomings of these models will help refine projections and improve transparency in the years ahead.
Image credit: Witsawat.S.
Edited by David E. Clapham, Howard Hughes Medical Institute, Children's Hospital Boston, Boston, MA, and approved January 20, 2012 (received for review September 8, 2011)
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History:
- Published in issue February 28, 2012.
- Published first February 13, 2012.
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Freely available online through the PNAS open access option.
Author Information
- Departments of aAnesthesiology, Pharmacology and Therapeutics,
- bCellular and Physiological Sciences, and
- cBiochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada, V6T 1Z3
Edited by David E. Clapham, Howard Hughes Medical Institute, Children's Hospital Boston, Boston, MA, and approved January 20, 2012 (received for review September 8, 2011)
Footnotes
- ↵1To whom correspondence may be addressed. E-mail: filip.vanpetegem{at}gmail.com or chrisahern{at}gmail.com.
Author contributions: M.F.S., F.V.P., and C.A.A. designed research; M.F.S., C.-C.T., and F.V.P. performed research; M.F.S., C.-C.T., F.V.P., and C.A.A. analyzed data; and M.F.S., F.V.P., and C.A.A. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
Data deposition: The atomic coordinates and structure factors reported in this paper have been deposited in the Protein Data Bank, www.pdb.org (PDB ID code 4DJC).
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1114748109/-/DCSupplemental.
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- Physiology
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