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Table of Contents

March 05, 2013; vol. 110 no. 10

This Week in PNAS

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    In This Issue
    PNAS March 5, 2013 110 (10) 3701-3702; https://doi.org/10.1073/iti1013110

Letters (Online Only)

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    Proteome size as the major factor determining mutation rates
    Steven E. Massey
    PNAS March 5, 2013 110 (10) E858-E859; https://doi.org/10.1073/pnas.1219306110
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    Reply to Massey: Drift does influence mutation-rate evolution
    Way Sung, Matthew S. Ackerman, Samuel F. Miller, Thomas G. Doak, and Michael Lynch
    PNAS March 5, 2013 110 (10) E860; https://doi.org/10.1073/pnas.1220650110

News Feature

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    Agents of influence
    • Front Matter
    Robert Frederick
    PNAS March 5, 2013 110 (10) 3703-3705; https://doi.org/10.1073/pnas.1302005110

Science and Culture

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    Curved-crease sculpture
    • Front Matter
    Nicholette Zeliadt
    PNAS March 5, 2013 110 (10) 3706; https://doi.org/10.1073/pnas.1302489110

Retrospective

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    Elwood V. Jensen (1920–2012): Father of the nuclear receptors
    Bert W. O’Malley and Sohaib Khan
    PNAS March 5, 2013 110 (10) 3707-3708; https://doi.org/10.1073/pnas.1301566110

Inner Workings

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    Deep cleaning
    • Front Matter
    Danielle Venton
    PNAS March 5, 2013 110 (10) 3709; https://doi.org/10.1073/pnas.1302491110

Core Concepts

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    Giant magnetoresistance
    • Front Matter
    Stephen Ornes
    PNAS March 5, 2013 110 (10) 3710; https://doi.org/10.1073/pnas.1302494110

Commentaries

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    Geography of forest disturbance
    Gregory P. Asner
    PNAS March 5, 2013 110 (10) 3711-3712; https://doi.org/10.1073/pnas.1300396110
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    Inviable immigrants drive diversification in the sea
    David W. Pfennig
    PNAS March 5, 2013 110 (10) 3713-3714; https://doi.org/10.1073/pnas.1300517110
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    Reemerging role of cable properties in action potential initiation
    Yunyong Ma and John R. Huguenard
    PNAS March 5, 2013 110 (10) 3715-3716; https://doi.org/10.1073/pnas.1300520110
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    Why we need more synaptogenic cell-adhesion proteins
    Nils Brose
    PNAS March 5, 2013 110 (10) 3717-3718; https://doi.org/10.1073/pnas.1300505110
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    Eurasian jays predict the food preferences of their mates
    Alan C. Kamil
    PNAS March 5, 2013 110 (10) 3719-3720; https://doi.org/10.1073/pnas.1300515110

PNAS Plus Significance Statements

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    PNAS Plus Significance Statements
    PNAS March 5, 2013 110 (10) 3721-3722; https://doi.org/10.1073/pnas.ss11010

Physical Sciences

  • Applied Mathematics

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      Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism
      Paul François, Guillaume Voisinne, Eric D. Siggia, Grégoire Altan-Bonnet, and Massimo Vergassola
      PNAS March 5, 2013 110 (10) E888-E897; https://doi.org/10.1073/pnas.1300752110
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      Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
      Jeremie Guedj, Harel Dahari, Libin Rong, Natasha D. Sansone, Richard E. Nettles, Scott J. Cotler, Thomas J. Layden, Susan L. Uprichard, and Alan S. Perelson
      PNAS March 5, 2013 110 (10) 3991-3996; https://doi.org/10.1073/pnas.1203110110
  • Applied Physical Sciences

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      Surface layering and melting in an ionic liquid studied by resonant soft X-ray reflectivity
      Markus Mezger, Benjamin M. Ocko, Harald Reichert, and Moshe Deutsch
      PNAS March 5, 2013 110 (10) 3733-3737; https://doi.org/10.1073/pnas.1211749110
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      Coupling the valley degree of freedom to antiferromagnetic order
      Xiao Li, Ting Cao, Qian Niu, Junren Shi, and Ji Feng
      PNAS March 5, 2013 110 (10) 3738-3742; https://doi.org/10.1073/pnas.1219420110
  • Chemistry

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      Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species
      Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Jung-Suk Choi, Ayyalusamy Ramamoorthy, Brandon T. Ruotolo, and Mi Hee Lim
      PNAS March 5, 2013 110 (10) 3743-3748; https://doi.org/10.1073/pnas.1220326110
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      Synthesis of an extra-large molecular sieve using proton sponges as organic structure-directing agents
      Raquel Martínez-Franco, Manuel Moliner, Yifeng Yun, Junliang Sun, Wei Wan, Xiaodong Zou, and Avelino Corma
      PNAS March 5, 2013 110 (10) 3749-3754; https://doi.org/10.1073/pnas.1220733110
    • You have access
      Elasticity, structure, and relaxation of extended proteins under force
      Guillaume Stirnemann, David Giganti, Julio M. Fernandez, and B. J. Berne
      PNAS March 5, 2013 110 (10) 3847-3852; https://doi.org/10.1073/pnas.1300596110
  • Earth, Atmospheric, and Planetary Sciences

    • Open Access
      Real-time 3D imaging of Haines jumps in porous media flow
      Steffen Berg, Holger Ott, Stephan A. Klapp, Alex Schwing, Rob Neiteler, Niels Brussee, Axel Makurat, Leon Leu, Frieder Enzmann, Jens-Oliver Schwarz, Michael Kersten, Sarah Irvine, and Marco Stampanoni
      PNAS March 5, 2013 110 (10) 3755-3759; https://doi.org/10.1073/pnas.1221373110
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      Worldwide data sets constrain the water vapor uptake coefficient in cloud formation
      Tomi Raatikainen, Athanasios Nenes, John H. Seinfeld, Ricardo Morales, Richard H. Moore, Terry L. Lathem, Sara Lance, Luz T. Padró, Jack J. Lin, Kate M. Cerully, Aikaterini Bougiatioti, Julie Cozic, Christopher R. Ruehl, Patrick Y. Chuang, Bruce E. Anderson, Richard C. Flagan, Haflidi Jonsson, Nikos Mihalopoulos, and James N. Smith
      PNAS March 5, 2013 110 (10) 3760-3764; https://doi.org/10.1073/pnas.1219591110
  • Environmental Sciences

    • Open Access
      Proteomic analysis of skeletal organic matrix from the stony coral Stylophora pistillata
      Jeana L. Drake, Tali Mass, Liti Haramaty, Ehud Zelzion, Debashish Bhattacharya, and Paul G. Falkowski
      PNAS March 5, 2013 110 (10) 3788-3793; https://doi.org/10.1073/pnas.1301419110
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      The steady-state mosaic of disturbance and succession across an old-growth Central Amazon forest landscape
      • From the Cover
      Jeffrey Q. Chambers, Robinson I. Negron-Juarez, Daniel Magnabosco Marra, Alan Di Vittorio, Joerg Tews, Dar Roberts, Gabriel H. P. M. Ribeiro, Susan E. Trumbore, and Niro Higuchi
      PNAS March 5, 2013 110 (10) 3949-3954; https://doi.org/10.1073/pnas.1202894110
  • Physics

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      Experimental demonstration of radicaloid character in a RuV=O intermediate in catalytic water oxidation
      Dooshaye Moonshiram, Igor Alperovich, Javier J. Concepcion, Thomas J. Meyer, and Yulia Pushkar
      PNAS March 5, 2013 110 (10) 3765-3770; https://doi.org/10.1073/pnas.1222102110
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      Relation between ordering and shear thinning in colloidal suspensions
      Xinliang Xu, Stuart A. Rice, and Aaron R. Dinner
      PNAS March 5, 2013 110 (10) 3771-3776; https://doi.org/10.1073/pnas.1301055110
    • Open Access
      Opening up three quantum boxes causes classically undetectable wavefunction collapse
      Richard E. George, Lucio M. Robledo, Owen J. E. Maroney, Machiel S. Blok, Hannes Bernien, Matthew L. Markham, Daniel J. Twitchen, John J. L. Morton, G. Andrew D. Briggs, and Ronald Hanson
      PNAS March 5, 2013 110 (10) 3777-3781; https://doi.org/10.1073/pnas.1208374110
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      Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations
      Christian Westendorf, Jose Negrete Jr., Albert J. Bae, Rabea Sandmann, Eberhard Bodenschatz, and Carsten Beta
      PNAS March 5, 2013 110 (10) 3853-3858; https://doi.org/10.1073/pnas.1216629110

Social Sciences

  • Economic Sciences

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      Variants at serotonin transporter and 2A receptor genes predict cooperative behavior differentially according to presence of punishment
      Kari B. Schroeder, Richard McElreath, and Daniel Nettle
      PNAS March 5, 2013 110 (10) 3955-3960; https://doi.org/10.1073/pnas.1216841110

Biological Sciences

  • Applied Biological Sciences

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      Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides
      Benedikt Wefers, Melanie Meyer, Oskar Ortiz, Martin Hrabé de Angelis, Jens Hansen, Wolfgang Wurst, and Ralf Kühn
      PNAS March 5, 2013 110 (10) 3782-3787; https://doi.org/10.1073/pnas.1218721110
  • Biochemistry

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      Nascent peptides that block protein synthesis in bacteria
      Christopher J. Woolstenhulme, Shankar Parajuli, David W. Healey, Diana P. Valverde, E. Nicholas Petersen, Agata L. Starosta, Nicholas R. Guydosh, W. Evan Johnson, Daniel N. Wilson, and Allen R. Buskirk
      PNAS March 5, 2013 110 (10) E878-E887; https://doi.org/10.1073/pnas.1219536110
    • Open Access
      Host–rabies virus protein–protein interactions as druggable antiviral targets
      Usha F. Lingappa, Xianfu Wu, Amanda Macieik, Shao Feng Yu, Andy Atuegbu, Michael Corpuz, Jean Francis, Christine Nichols, Alfredo Calayag, Hong Shi, James A. Ellison, Emma K. T. Harrell, Vinod Asundi, Jaisri R. Lingappa, M. Dharma Prasad, W. Ian Lipkin, Debendranath Dey, Clarence R. Hurt, Vishwanath R. Lingappa, William J. Hansen, and Charles E. Rupprecht
      PNAS March 5, 2013 110 (10) E861-E868; https://doi.org/10.1073/pnas.1210198110
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      Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters
      Birgit Dreier, Annemarie Honegger, Christian Hess, Gabriela Nagy-Davidescu, Peer R. E. Mittl, Markus G. Grütter, Natalya Belousova, Galina Mikheeva, Victor Krasnykh, and Andreas Plückthun
      PNAS March 5, 2013 110 (10) E869-E877; https://doi.org/10.1073/pnas.1213653110
    • You have access
      Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species
      Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Jung-Suk Choi, Ayyalusamy Ramamoorthy, Brandon T. Ruotolo, and Mi Hee Lim
      PNAS March 5, 2013 110 (10) 3743-3748; https://doi.org/10.1073/pnas.1220326110
    • Open Access
      Proteomic analysis of skeletal organic matrix from the stony coral Stylophora pistillata
      Jeana L. Drake, Tali Mass, Liti Haramaty, Ehud Zelzion, Debashish Bhattacharya, and Paul G. Falkowski
      PNAS March 5, 2013 110 (10) 3788-3793; https://doi.org/10.1073/pnas.1301419110
    • You have access
      Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits
      PuiYee Chan, Celestine J. Thomas, Stephen R. Sprang, and Gregory G. Tall
      PNAS March 5, 2013 110 (10) 3794-3799; https://doi.org/10.1073/pnas.1220943110
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      UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy
      Takafumi Tasaki, Sung Tae Kim, Adriana Zakrzewska, Bo Eun Lee, Min Jueng Kang, Young Dong Yoo, Hyun Joo Cha-Molstad, Joonsung Hwang, Nak Kyun Soung, Ki Sa Sung, Su-Hyeon Kim, Minh Dang Nguyen, Ming Sun, Eugene C. Yi, Bo Yeon Kim, and Yong Tae Kwon
      PNAS March 5, 2013 110 (10) 3800-3805; https://doi.org/10.1073/pnas.1217358110
    • You have access
      Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily
      Tove Sjögren, Johan Nord, Margareta Ek, Patrik Johansson, Gang Liu, and Stefan Geschwindner
      PNAS March 5, 2013 110 (10) 3806-3811; https://doi.org/10.1073/pnas.1218504110
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      Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis
      Lasse Jenner, Agata L. Starosta, Daniel S. Terry, Aleksandra Mikolajka, Liudmila Filonava, Marat Yusupov, Scott C. Blanchard, Daniel N. Wilson, and Gulnara Yusupova
      PNAS March 5, 2013 110 (10) 3812-3816; https://doi.org/10.1073/pnas.1216691110
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      Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens
      Li Li, Andrés Palencia, Tiit Lukk, Zhi Li, Zaida A. Luthey-Schulten, Stephen Cusack, Susan A. Martinis, and Michal T. Boniecki
      PNAS March 5, 2013 110 (10) 3817-3822; https://doi.org/10.1073/pnas.1218374110
    • You have access
      The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes
      Henning J. kleine Balderhaar, Jens Lachmann, Erdal Yavavli, Cornelia Bröcker, Anna Lürick, and Christian Ungermann
      PNAS March 5, 2013 110 (10) 3823-3828; https://doi.org/10.1073/pnas.1221785110
    • Open Access
      Global structural motions from the strain of a single hydrogen bond
      Jens Danielsson, Wael Awad, Kadhirvel Saraboji, Martin Kurnik, Lisa Lang, Lina Leinartaitė, Stefan L. Marklund, Derek T. Logan, and Mikael Oliveberg
      PNAS March 5, 2013 110 (10) 3829-3834; https://doi.org/10.1073/pnas.1217306110
    • You have access
      Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase
      Ellen C. Minnihan, Nozomi Ando, Edward J. Brignole, Lisa Olshansky, Johnathan Chittuluru, Francisco J. Asturias, Catherine L. Drennan, Daniel G. Nocera, and JoAnne Stubbe
      PNAS March 5, 2013 110 (10) 3835-3840; https://doi.org/10.1073/pnas.1220691110
    • You have access
      Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens
      Steven M. Damo, Thomas E. Kehl-Fie, Norie Sugitani, Marilyn E. Holt, Subodh Rathi, Wesley J. Murphy, Yaofang Zhang, Christine Betz, Laura Hench, Günter Fritz, Eric P. Skaar, and Walter J. Chazin
      PNAS March 5, 2013 110 (10) 3841-3846; https://doi.org/10.1073/pnas.1220341110
  • Biophysics and Computational Biology

    • You have access
      Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism
      Paul François, Guillaume Voisinne, Eric D. Siggia, Grégoire Altan-Bonnet, and Massimo Vergassola
      PNAS March 5, 2013 110 (10) E888-E897; https://doi.org/10.1073/pnas.1300752110
    • You have access
      Elasticity, structure, and relaxation of extended proteins under force
      Guillaume Stirnemann, David Giganti, Julio M. Fernandez, and B. J. Berne
      PNAS March 5, 2013 110 (10) 3847-3852; https://doi.org/10.1073/pnas.1300596110
    • You have access
      Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations
      Christian Westendorf, Jose Negrete Jr., Albert J. Bae, Rabea Sandmann, Eberhard Bodenschatz, and Carsten Beta
      PNAS March 5, 2013 110 (10) 3853-3858; https://doi.org/10.1073/pnas.1216629110
    • Open Access
      Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching using fluorescence microscopy
      Graeme A. King, Peter Gross, Ulrich Bockelmann, Mauro Modesti, Gijs J. L. Wuite, and Erwin J. G. Peterman
      PNAS March 5, 2013 110 (10) 3859-3864; https://doi.org/10.1073/pnas.1213676110
    • Open Access
      Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry
      Xinghua Zhang, Hu Chen, Shimin Le, Ioulia Rouzina, Patrick S. Doyle, and Jie Yan
      PNAS March 5, 2013 110 (10) 3865-3870; https://doi.org/10.1073/pnas.1213740110
    • You have access
      SOD1 exhibits allosteric frustration to facilitate metal binding affinity
      Atanu Das and Steven S. Plotkin
      PNAS March 5, 2013 110 (10) 3871-3876; https://doi.org/10.1073/pnas.1216597110
    • You have access
      eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition
      Michael J. Osborne, Laurent Volpon, Jack A. Kornblatt, Biljana Culjkovic-Kraljacic, Aurélie Baguet, and Katherine L. B. Borden
      PNAS March 5, 2013 110 (10) 3877-3882; https://doi.org/10.1073/pnas.1216862110
    • You have access
      Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5
      Lei Song and Joseph Santos-Sacchi
      PNAS March 5, 2013 110 (10) 3883-3888; https://doi.org/10.1073/pnas.1218341110
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      Structure of Sr-substituted photosystem II at 2.1 Å resolution and its implications in the mechanism of water oxidation
      Faisal Hammad Mekky Koua, Yasufumi Umena, Keisuke Kawakami, and Jian-Ren Shen
      PNAS March 5, 2013 110 (10) 3889-3894; https://doi.org/10.1073/pnas.1219922110
  • Cell Biology

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      Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis
      Mara Schvarzstein, Divya Pattabiraman, Joshua N. Bembenek, and Anne M. Villeneuve
      PNAS March 5, 2013 110 (10) E898-E907; https://doi.org/10.1073/pnas.1213888110
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      MOZ increases p53 acetylation and premature senescence through its complex formation with PML
      Susumu Rokudai, Oleg Laptenko, Suzzette M. Arnal, Yoichi Taya, Issay Kitabayashi, and Carol Prives
      PNAS March 5, 2013 110 (10) 3895-3900; https://doi.org/10.1073/pnas.1300490110
    • Open Access
      Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
      Eric Wang, Shinpei Kawaoka, Ming Yu, Junwei Shi, Ting Ni, Wenjing Yang, Jun Zhu, Robert G. Roeder, and Christopher R. Vakoc
      PNAS March 5, 2013 110 (10) 3901-3906; https://doi.org/10.1073/pnas.1301045110
    • Open Access
      Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel
      Liang Jin, Tao Feng, Hung Ping Shih, Ricardo Zerda, Angela Luo, Jasper Hsu, Alborz Mahdavi, Maike Sander, David A. Tirrell, Arthur D. Riggs, and Hsun Teresa Ku
      PNAS March 5, 2013 110 (10) 3907-3912; https://doi.org/10.1073/pnas.1301889110
    • Open Access
      Design of a superior cytokine antagonist for topical ophthalmic use
      Jinzhao Hou, Sharon A. Townson, Joseph T. Kovalchin, Allyson Masci, Olga Kiner, Yanqun Shu, Bracken M. King, Emily Schirmer, Kathryn Golden, Christoph Thomas, K. Christopher Garcia, Gregory Zarbis-Papastoitsis, Eric S. Furfine, and Thomas M. Barnes
      PNAS March 5, 2013 110 (10) 3913-3918; https://doi.org/10.1073/pnas.1217996110
    • Open Access
      Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
      Fabienne Guillaumond, Julie Leca, Orianne Olivares, Marie-Noëlle Lavaut, Nicolas Vidal, Patrice Berthezène, Nelson Javier Dusetti, Céline Loncle, Ezequiel Calvo, Olivier Turrini, Juan Lucio Iovanna, Richard Tomasini, and Sophie Vasseur
      PNAS March 5, 2013 110 (10) 3919-3924; https://doi.org/10.1073/pnas.1219555110
    • Open Access
      Avalanche-like behavior in ciliary import
      William B. Ludington, Kimberly A. Wemmer, Karl F. Lechtreck, George B. Witman, and Wallace F. Marshall
      PNAS March 5, 2013 110 (10) 3925-3930; https://doi.org/10.1073/pnas.1217354110
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      DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions
      Alessandra Insinga, Angelo Cicalese, Mario Faretta, Barbara Gallo, Luisa Albano, Simona Ronzoni, Laura Furia, Andrea Viale, and Pier Giuseppe Pelicci
      PNAS March 5, 2013 110 (10) 3931-3936; https://doi.org/10.1073/pnas.1213394110
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      Direct reprogramming by oncogenic Ras and Myc
      Irene Ischenko, Jizu Zhi, Ute M. Moll, Alice Nemajerova, and Oleksi Petrenko
      PNAS March 5, 2013 110 (10) 3937-3942; https://doi.org/10.1073/pnas.1219592110
  • Developmental Biology

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      Responses of hair follicle–associated structures to loss of planar cell polarity signaling
      Hao Chang and Jeremy Nathans
      PNAS March 5, 2013 110 (10) E908-E917; https://doi.org/10.1073/pnas.1301430110
    • You have access
      Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma
      Michael Chiorazzi, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W. Maurer, Stella M. Ranuncolo, Hong Zhao, Weihong Xu, Wing-Chung C. Chan, Elaine S. Jaffe, Randy D. Gascoyne, Elias Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M. Rimsza, Shai Shaham, and Louis M. Staudt
      PNAS March 5, 2013 110 (10) 3943-3948; https://doi.org/10.1073/pnas.1217271110
  • Ecology

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      The steady-state mosaic of disturbance and succession across an old-growth Central Amazon forest landscape
      • From the Cover
      Jeffrey Q. Chambers, Robinson I. Negron-Juarez, Daniel Magnabosco Marra, Alan Di Vittorio, Joerg Tews, Dar Roberts, Gabriel H. P. M. Ribeiro, Susan E. Trumbore, and Niro Higuchi
      PNAS March 5, 2013 110 (10) 3949-3954; https://doi.org/10.1073/pnas.1202894110
  • Evolution

    • You have access
      Variants at serotonin transporter and 2A receptor genes predict cooperative behavior differentially according to presence of punishment
      Kari B. Schroeder, Richard McElreath, and Daniel Nettle
      PNAS March 5, 2013 110 (10) 3955-3960; https://doi.org/10.1073/pnas.1216841110
    • You have access
      Long prereproductive selection and divergence by depth in a Caribbean candelabrum coral
      Carlos Prada and Michael E. Hellberg
      PNAS March 5, 2013 110 (10) 3961-3966; https://doi.org/10.1073/pnas.1208931110
    • You have access
      Functional consequences of sequence variation in the pheromone biosynthetic gene pgFAR for Ostrinia moths
      Jean-Marc Lassance, Marjorie A. Liénard, Binu Antony, Shuguang Qian, Takeshi Fujii, Jun Tabata, Yukio Ishikawa, and Christer Löfstedt
      PNAS March 5, 2013 110 (10) 3967-3972; https://doi.org/10.1073/pnas.1208706110
    • You have access
      Plant mating system transitions drive the macroevolution of defense strategies
      Stuart A. Campbell and André Kessler
      PNAS March 5, 2013 110 (10) 3973-3978; https://doi.org/10.1073/pnas.1213867110
  • Genetics

    • Open Access
      Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos
      Soyoung Kim, Takao Ishidate, Rita Sharma, Martha C. Soto, Darryl Conte Jr., Craig C. Mello, and Masaki Shirayama
      PNAS March 5, 2013 110 (10) E918-E927; https://doi.org/10.1073/pnas.1300769110
    • You have access
      Anatomical and transcriptional dynamics of maize embryonic leaves during seed germination
      Wen-Yu Liu, Yao-Ming Chang, Sean Chun-Chang Chen, Chen-Hua Lu, Yeh-Hwa Wu, Mei-Yeh Jade Lu, Di-Rong Chen, Arthur Chun-Chieh Shih, Chiou-Rong Sheue, Hsuan-Cheng Huang, Chun-Ping Yu, Hsin-Hung Lin, Shin-Han Shiu, Maurice Sun-Ben Ku, and Wen-Hsiung Li
      PNAS March 5, 2013 110 (10) 3979-3984; https://doi.org/10.1073/pnas.1301009110
    • Open Access
      Rare variant detection using family-based sequencing analysis
      Gang Peng, Yu Fan, Timothy B. Palculict, Peidong Shen, E. Cristy Ruteshouser, Aung-Kyaw Chi, Ronald W. Davis, Vicki Huff, Curt Scharfe, and Wenyi Wang
      PNAS March 5, 2013 110 (10) 3985-3990; https://doi.org/10.1073/pnas.1222158110
  • Medical Sciences

    • You have access
      Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target
      Liaquat S. Verjee, Jennifer S. N. Verhoekx, James K. K. Chan, Thomas Krausgruber, Vicky Nicolaidou, David Izadi, Dominique Davidson, Marc Feldmann, Kim S. Midwood, and Jagdeep Nanchahal
      PNAS March 5, 2013 110 (10) E928-E937; https://doi.org/10.1073/pnas.1301100110
    • You have access
      Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
      Jeremie Guedj, Harel Dahari, Libin Rong, Natasha D. Sansone, Richard E. Nettles, Scott J. Cotler, Thomas J. Layden, Susan L. Uprichard, and Alan S. Perelson
      PNAS March 5, 2013 110 (10) 3991-3996; https://doi.org/10.1073/pnas.1203110110
    • You have access
      Engineering of a functional bone organ through endochondral ossification
      Celeste Scotti, Elia Piccinini, Hitoshi Takizawa, Atanas Todorov, Paul Bourgine, Adam Papadimitropoulos, Andrea Barbero, Markus G. Manz, and Ivan Martin
      PNAS March 5, 2013 110 (10) 3997-4002; https://doi.org/10.1073/pnas.1220108110
    • You have access
      Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration
      Arun K. Sharma, Matthew I. Bury, Natalie J. Fuller, Andrew J. Marks, David M. Kollhoff, Manoj V. Rao, Partha V. Hota, Derek J. Matoka, Seby L. Edassery, Hatim Thaker, John F. Sarwark, Joseph A. Janicki, Guillermo A. Ameer, and Earl Y. Cheng
      PNAS March 5, 2013 110 (10) 4003-4008; https://doi.org/10.1073/pnas.1220764110
    • Open Access
      Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
      Andrea Sottoriva, Inmaculada Spiteri, Sara G. M. Piccirillo, Anestis Touloumis, V. Peter Collins, John C. Marioni, Christina Curtis, Colin Watts, and Simon Tavaré
      PNAS March 5, 2013 110 (10) 4009-4014; https://doi.org/10.1073/pnas.1219747110
    • You have access
      Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo
      Christian Posch, Homayoun Moslehi, Luzviminda Feeney, Gary A. Green, Anoosheh Ebaee, Valentin Feichtenschlager, Kim Chong, Lily Peng, Michelle T. Dimon, Thomas Phillips, Adil I. Daud, Timothy H. McCalmont, Philip E. LeBoit, and Susana Ortiz-Urda
      PNAS March 5, 2013 110 (10) 4015-4020; https://doi.org/10.1073/pnas.1216013110
  • Microbiology

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      Mechanistic link between β barrel assembly and the initiation of autotransporter secretion
      Olga Pavlova, Janine H. Peterson, Raffaele Ieva, and Harris D. Bernstein
      PNAS March 5, 2013 110 (10) E938-E947; https://doi.org/10.1073/pnas.1219076110
    • You have access
      Engineering furfural tolerance in Escherichia coli improves the fermentation of lignocellulosic sugars into renewable chemicals
      Xuan Wang, Lorraine P. Yomano, James Y. Lee, Sean W. York, Huabao Zheng, Michael T. Mullinnix, K. T. Shanmugam, and Lonnie O. Ingram
      PNAS March 5, 2013 110 (10) 4021-4026; https://doi.org/10.1073/pnas.1217958110
  • Neuroscience

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      The δ2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites
      Kazuhisa Kohda, Wataru Kakegawa, Shinji Matsuda, Tadashi Yamamoto, Hisashi Hirano, and Michisuke Yuzaki
      PNAS March 5, 2013 110 (10) E948-E957; https://doi.org/10.1073/pnas.1218380110
    • You have access
      Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression
      Sadegh Nabavi, Helmut W. Kessels, Stephanie Alfonso, Jonathan Aow, Rocky Fox, and Roberto Malinow
      PNAS March 5, 2013 110 (10) 4027-4032; https://doi.org/10.1073/pnas.1219454110
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      Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression
      Helmut W. Kessels, Sadegh Nabavi, and Roberto Malinow
      PNAS March 5, 2013 110 (10) 4033-4038; https://doi.org/10.1073/pnas.1219605110
    • You have access
      DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
      Trent A. Watkins, Bei Wang, Sarah Huntwork-Rodriguez, Jing Yang, Zhiyu Jiang, Jeffrey Eastham-Anderson, Zora Modrusan, Joshua S. Kaminker, Marc Tessier-Lavigne, and Joseph W. Lewcock
      PNAS March 5, 2013 110 (10) 4039-4044; https://doi.org/10.1073/pnas.1211074110
    • You have access
      Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death
      Derek S. Welsbie, Zhiyong Yang, Yan Ge, Katherine L. Mitchell, Xinrong Zhou, Scott E. Martin, Cynthia A. Berlinicke, Laszlo Hackler Jr., John Fuller, Jie Fu, Li-hui Cao, Bing Han, Douglas Auld, Tian Xue, Syu-ichi Hirai, Lucie Germain, Caroline Simard-Bisson, Richard Blouin, Judy V. Nguyen, Chung-ha O. Davis, Raymond A. Enke, Sanford L. Boye, Shannath L. Merbs, Nicholas Marsh-Armstrong, William W. Hauswirth, Aaron DiAntonio, Robert W. Nickells, James Inglese, Justin Hanes, King-Wai Yau, Harry A. Quigley, and Donald J. Zack
      PNAS March 5, 2013 110 (10) 4045-4050; https://doi.org/10.1073/pnas.1211284110
    • You have access
      Spatial mismatch between the Na+ flux and spike initiation in axon initial segment
      • From the Cover
      Gytis Baranauskas, Yaron David, and Ilya A. Fleidervish
      PNAS March 5, 2013 110 (10) 4051-4056; https://doi.org/10.1073/pnas.1215125110
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      Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases
      • From the Cover
      Yeong Shin Yim, Younghee Kwon, Jungyong Nam, Hong In Yoon, Kangduk Lee, Dong Goo Kim, Eunjoon Kim, Chul Hoon Kim, and Jaewon Ko
      PNAS March 5, 2013 110 (10) 4057-4062; https://doi.org/10.1073/pnas.1209881110
    • You have access
      Ambient noise induces independent shifts in call frequency and amplitude within the Lombard effect in echolocating bats
      • From the Cover
      Steffen R. Hage, Tinglei Jiang, Sean W. Berquist, Jiang Feng, and Walter Metzner
      PNAS March 5, 2013 110 (10) 4063-4068; https://doi.org/10.1073/pnas.1211533110
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      Reactive astrocytes secrete lcn2 to promote neuron death
      Fangfang Bi, Cao Huang, Jianbin Tong, Guang Qiu, Bo Huang, Qinxue Wu, Fang Li, Zuoshang Xu, Robert Bowser, Xu-Gang Xia, and Hongxia Zhou
      PNAS March 5, 2013 110 (10) 4069-4074; https://doi.org/10.1073/pnas.1218497110
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      Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelin
      Berit E. Powers, Drew L. Sellers, Emilie A. Lovelett, Willy Cheung, Sheida P. Aalami, Nikolai Zapertov, Don O. Maris, and Philip J. Horner
      PNAS March 5, 2013 110 (10) 4075-4080; https://doi.org/10.1073/pnas.1210293110
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      The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map
      Gina E. Elsen, Rebecca D. Hodge, Francesco Bedogni, Ray A. M. Daza, Branden R. Nelson, Naoko Shiba, Steven L. Reiner, and Robert F. Hevner
      PNAS March 5, 2013 110 (10) 4081-4086; https://doi.org/10.1073/pnas.1209076110
    • You have access
      Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
      Bong-Kyu Choi, Mal-Gi Choi, Jae-Yeol Kim, Yoosoo Yang, Ying Lai, Dae-Hyuk Kweon, Nam Ki Lee, and Yeon-Kyun Shin
      PNAS March 5, 2013 110 (10) 4087-4092; https://doi.org/10.1073/pnas.1218424110
    • Open Access
      Dorsolateral caudate nucleus differentiates cocaine from natural reward-associated contextual cues
      Hua-Shan Liu, Svetlana Chefer, Hanbing Lu, Karine Guillem, William Rea, Pradeep Kurup, Yihong Yang, Laura Peoples, and Elliot A. Stein
      PNAS March 5, 2013 110 (10) 4093-4098; https://doi.org/10.1073/pnas.1207531110
  • Pharmacology

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      Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure
      Kamel Maouche, Kahina Medjber, Jean-Marie Zahm, Franck Delavoie, Christine Terryn, Christelle Coraux, Stéphanie Pons, Isabelle Cloëz-Tayarani, Uwe Maskos, Philippe Birembaut, and Jean-Marie Tournier
      PNAS March 5, 2013 110 (10) 4099-4104; https://doi.org/10.1073/pnas.1216939110
  • Physiology

    • Open Access
      Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics
      Marie A. Schroeder, Mohammad A. Ali, Alzbeta Hulikova, Claudiu T. Supuran, Kieran Clarke, Richard D. Vaughan-Jones, Damian J. Tyler, and Pawel Swietach
      PNAS March 5, 2013 110 (10) E958-E967; https://doi.org/10.1073/pnas.1213471110
    • You have access
      Convergence of IRBIT, phosphatidylinositol (4,5) bisphosphate, and WNK/SPAK kinases in regulation of the Na+-HCO3− cotransporters family
      Jeong Hee Hong, Dongki Yang, Nikolay Shcheynikov, Ehud Ohana, Dong Min Shin, and Shmuel Muallem
      PNAS March 5, 2013 110 (10) 4105-4110; https://doi.org/10.1073/pnas.1221410110
  • Plant Biology

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      Flavodiiron proteins Flv1 and Flv3 enable cyanobacterial growth and photosynthesis under fluctuating light
      Yagut Allahverdiyeva, Henna Mustila, Maria Ermakova, Luca Bersanini, Pierre Richaud, Ghada Ajlani, Natalia Battchikova, Laurent Cournac, and Eva-Mari Aro
      PNAS March 5, 2013 110 (10) 4111-4116; https://doi.org/10.1073/pnas.1221194110
    • Open Access
      3′ fragment of miR173-programmed RISC-cleaved RNA is protected from degradation in a complex with RISC and SGS3
      Manabu Yoshikawa, Taichiro Iki, Yasuhiro Tsutsui, Kyoko Miyashita, R. Scott Poethig, Yoshiki Habu, and Masayuki Ishikawa
      PNAS March 5, 2013 110 (10) 4117-4122; https://doi.org/10.1073/pnas.1217050110
  • Psychological and Cognitive Sciences

    • You have access
      Evidence suggesting that desire-state attribution may govern food sharing in Eurasian jays
      • From the Cover
      Ljerka Ostojić, Rachael C. Shaw, Lucy G. Cheke, and Nicola S. Clayton
      PNAS March 5, 2013 110 (10) 4123-4128; https://doi.org/10.1073/pnas.1209926110
    • You have access
      Stress increases aversive prediction error signal in the ventral striatum
      Oliver J. Robinson, Cassie Overstreet, Danielle R. Charney, Katherine Vytal, and Christian Grillon
      PNAS March 5, 2013 110 (10) 4129-4133; https://doi.org/10.1073/pnas.1213923110
  • Sustainability Science

    • Open Access
      Recent land use change in the Western Corn Belt threatens grasslands and wetlands
      Christopher K. Wright and Michael C. Wimberly
      PNAS March 5, 2013 110 (10) 4134-4139; https://doi.org/10.1073/pnas.1215404110
  • Systems Biology

    • You have access
      Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program
      Xin Guo, Allister Bernard, David A. Orlando, Steven B. Haase, and Alexander J. Hartemink
      PNAS March 5, 2013 110 (10) E968-E977; https://doi.org/10.1073/pnas.1120991110
    • Open Access
      Rate of environmental change determines stress response specificity
      Jonathan W. Young, James C. W. Locke, and Michael B. Elowitz
      PNAS March 5, 2013 110 (10) 4140-4145; https://doi.org/10.1073/pnas.1213060110

Corrections

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    Correction for Verman and Harris, PNAS introduces new magazine section
    PNAS March 5, 2013 110 (10) 4148; https://doi.org/10.1073/pnas.1302830110
  • You have access
    Correction for Zhang et al., TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21
    PNAS March 5, 2013 110 (10) 4148; https://doi.org/10.1073/pnas.1300693110
  • You have access
    Correction for Morin et al., Genome sequence of the button mushroom Agaricus bisporus reveals mechanisms governing adaptation to a humic-rich ecological niche
    PNAS March 5, 2013 110 (10) 4146; https://doi.org/10.1073/pnas.1300201110
  • You have access
    Correction for Gururaj et al., MTA1, a transcriptional activator of breast cancer amplified sequence 3
    PNAS March 5, 2013 110 (10) 4147-4148; https://doi.org/10.1073/pnas.1300338110
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Proceedings of the National Academy of Sciences: 110 (10)
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