Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

    Benedikt Wefers, Melanie Meyer, Oskar Ortiz, Martin Hrabé de Angelis, Jens Hansen, Wolfgang Wurst, and Ralf Kühn

    PNAS March 5, 2013 110 (10) 3782-3787; https://doi.org/10.1073/pnas.1218721110

• Biochemistry

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    Nascent peptides that block protein synthesis in bacteria

    Christopher J. Woolstenhulme, Shankar Parajuli, David W. Healey, Diana P. Valverde, E. Nicholas Petersen, Agata L. Starosta, Nicholas R. Guydosh, W. Evan Johnson, Daniel N. Wilson, and Allen R. Buskirk

    PNAS March 5, 2013 110 (10) E878-E887; https://doi.org/10.1073/pnas.1219536110
  • Open Access

    Host–rabies virus protein–protein interactions as druggable antiviral targets

    Usha F. Lingappa, Xianfu Wu, Amanda Macieik, Shao Feng Yu, Andy Atuegbu, Michael Corpuz, Jean Francis, Christine Nichols, Alfredo Calayag, Hong Shi, James A. Ellison, Emma K. T. Harrell, Vinod Asundi, Jaisri R. Lingappa, M. Dharma Prasad, W. Ian Lipkin, Debendranath Dey, Clarence R. Hurt, Vishwanath R. Lingappa, William J. Hansen, and Charles E. Rupprecht

    PNAS March 5, 2013 110 (10) E861-E868; https://doi.org/10.1073/pnas.1210198110
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    Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters

    Birgit Dreier, Annemarie Honegger, Christian Hess, Gabriela Nagy-Davidescu, Peer R. E. Mittl, Markus G. Grütter, Natalya Belousova, Galina Mikheeva, Victor Krasnykh, and Andreas Plückthun

    PNAS March 5, 2013 110 (10) E869-E877; https://doi.org/10.1073/pnas.1213653110
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    Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species

    Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Jung-Suk Choi, Ayyalusamy Ramamoorthy, Brandon T. Ruotolo, and Mi Hee Lim

    PNAS March 5, 2013 110 (10) 3743-3748; https://doi.org/10.1073/pnas.1220326110
  • Open Access

    Proteomic analysis of skeletal organic matrix from the stony coral Stylophora pistillata

    Jeana L. Drake, Tali Mass, Liti Haramaty, Ehud Zelzion, Debashish Bhattacharya, and Paul G. Falkowski

    PNAS March 5, 2013 110 (10) 3788-3793; https://doi.org/10.1073/pnas.1301419110

    See companion article:

    • Coral skeletal proteome response

      - May 03, 2013
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    Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits

    PuiYee Chan, Celestine J. Thomas, Stephen R. Sprang, and Gregory G. Tall

    PNAS March 5, 2013 110 (10) 3794-3799; https://doi.org/10.1073/pnas.1220943110
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    UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy

    Takafumi Tasaki, Sung Tae Kim, Adriana Zakrzewska, Bo Eun Lee, Min Jueng Kang, Young Dong Yoo, Hyun Joo Cha-Molstad, Joonsung Hwang, Nak Kyun Soung, Ki Sa Sung, Su-Hyeon Kim, Minh Dang Nguyen, Ming Sun, Eugene C. Yi, Bo Yeon Kim, and Yong Tae Kwon

    PNAS March 5, 2013 110 (10) 3800-3805; https://doi.org/10.1073/pnas.1217358110
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    Crystal structure of microsomal prostaglandin E₂ synthase provides insight into diversity in the MAPEG superfamily

    Tove Sjögren, Johan Nord, Margareta Ek, Patrik Johansson, Gang Liu, and Stefan Geschwindner

    PNAS March 5, 2013 110 (10) 3806-3811; https://doi.org/10.1073/pnas.1218504110
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    Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

    Lasse Jenner, Agata L. Starosta, Daniel S. Terry, Aleksandra Mikolajka, Liudmila Filonava, Marat Yusupov, Scott C. Blanchard, Daniel N. Wilson, and Gulnara Yusupova

    PNAS March 5, 2013 110 (10) 3812-3816; https://doi.org/10.1073/pnas.1216691110
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    Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens

    Li Li, Andrés Palencia, Tiit Lukk, Zhi Li, Zaida A. Luthey-Schulten, Stephen Cusack, Susan A. Martinis, and Michal T. Boniecki

    PNAS March 5, 2013 110 (10) 3817-3822; https://doi.org/10.1073/pnas.1218374110
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    The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes

    Henning J. kleine Balderhaar, Jens Lachmann, Erdal Yavavli, Cornelia Bröcker, Anna Lürick, and Christian Ungermann

    PNAS March 5, 2013 110 (10) 3823-3828; https://doi.org/10.1073/pnas.1221785110
  • Open Access

    Global structural motions from the strain of a single hydrogen bond

    Jens Danielsson, Wael Awad, Kadhirvel Saraboji, Martin Kurnik, Lisa Lang, Lina Leinartaitė, Stefan L. Marklund, Derek T. Logan, and Mikael Oliveberg

    PNAS March 5, 2013 110 (10) 3829-3834; https://doi.org/10.1073/pnas.1217306110
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    Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase

    Ellen C. Minnihan, Nozomi Ando, Edward J. Brignole, Lisa Olshansky, Johnathan Chittuluru, Francisco J. Asturias, Catherine L. Drennan, Daniel G. Nocera, and JoAnne Stubbe

    PNAS March 5, 2013 110 (10) 3835-3840; https://doi.org/10.1073/pnas.1220691110
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    Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

    Steven M. Damo, Thomas E. Kehl-Fie, Norie Sugitani, Marilyn E. Holt, Subodh Rathi, Wesley J. Murphy, Yaofang Zhang, Christine Betz, Laura Hench, Günter Fritz, Eric P. Skaar, and Walter J. Chazin

    PNAS March 5, 2013 110 (10) 3841-3846; https://doi.org/10.1073/pnas.1220341110

• Biophysics and Computational Biology

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    Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism

    Paul François, Guillaume Voisinne, Eric D. Siggia, Grégoire Altan-Bonnet, and Massimo Vergassola

    PNAS March 5, 2013 110 (10) E888-E897; https://doi.org/10.1073/pnas.1300752110
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    Elasticity, structure, and relaxation of extended proteins under force

    Guillaume Stirnemann, David Giganti, Julio M. Fernandez, and B. J. Berne

    PNAS March 5, 2013 110 (10) 3847-3852; https://doi.org/10.1073/pnas.1300596110
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    Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations

    Christian Westendorf, Jose Negrete Jr., Albert J. Bae, Rabea Sandmann, Eberhard Bodenschatz, and Carsten Beta

    PNAS March 5, 2013 110 (10) 3853-3858; https://doi.org/10.1073/pnas.1216629110
  • Open Access

    Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching using fluorescence microscopy

    Graeme A. King, Peter Gross, Ulrich Bockelmann, Mauro Modesti, Gijs J. L. Wuite, and Erwin J. G. Peterman

    PNAS March 5, 2013 110 (10) 3859-3864; https://doi.org/10.1073/pnas.1213676110

    See companion article:

    • Nature of DNA overstretching

      - Feb 19, 2013
  • Open Access

    Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry

    Xinghua Zhang, Hu Chen, Shimin Le, Ioulia Rouzina, Patrick S. Doyle, and Jie Yan

    PNAS March 5, 2013 110 (10) 3865-3870; https://doi.org/10.1073/pnas.1213740110

    See companion article:

    • Three competing mechanisms of DNA overstretching

      - Feb 19, 2013
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    SOD1 exhibits allosteric frustration to facilitate metal binding affinity

    Atanu Das and Steven S. Plotkin

    PNAS March 5, 2013 110 (10) 3871-3876; https://doi.org/10.1073/pnas.1216597110
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    eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition

    Michael J. Osborne, Laurent Volpon, Jack A. Kornblatt, Biljana Culjkovic-Kraljacic, Aurélie Baguet, and Katherine L. B. Borden

    PNAS March 5, 2013 110 (10) 3877-3882; https://doi.org/10.1073/pnas.1216862110
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    Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5

    Lei Song and Joseph Santos-Sacchi

    PNAS March 5, 2013 110 (10) 3883-3888; https://doi.org/10.1073/pnas.1218341110
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    Structure of Sr-substituted photosystem II at 2.1 Å resolution and its implications in the mechanism of water oxidation

    Faisal Hammad Mekky Koua, Yasufumi Umena, Keisuke Kawakami, and Jian-Ren Shen

    PNAS March 5, 2013 110 (10) 3889-3894; https://doi.org/10.1073/pnas.1219922110

• Cell Biology

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    Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis

    Mara Schvarzstein, Divya Pattabiraman, Joshua N. Bembenek, and Anne M. Villeneuve

    PNAS March 5, 2013 110 (10) E898-E907; https://doi.org/10.1073/pnas.1213888110
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    MOZ increases p53 acetylation and premature senescence through its complex formation with PML

    Susumu Rokudai, Oleg Laptenko, Suzzette M. Arnal, Yoichi Taya, Issay Kitabayashi, and Carol Prives

    PNAS March 5, 2013 110 (10) 3895-3900; https://doi.org/10.1073/pnas.1300490110
  • Open Access

    Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

    Eric Wang, Shinpei Kawaoka, Ming Yu, Junwei Shi, Ting Ni, Wenjing Yang, Jun Zhu, Robert G. Roeder, and Christopher R. Vakoc

    PNAS March 5, 2013 110 (10) 3901-3906; https://doi.org/10.1073/pnas.1301045110
  • Open Access

    Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel

    Liang Jin, Tao Feng, Hung Ping Shih, Ricardo Zerda, Angela Luo, Jasper Hsu, Alborz Mahdavi, Maike Sander, David A. Tirrell, Arthur D. Riggs, and Hsun Teresa Ku

    PNAS March 5, 2013 110 (10) 3907-3912; https://doi.org/10.1073/pnas.1301889110
  • Open Access

    Design of a superior cytokine antagonist for topical ophthalmic use

    Jinzhao Hou, Sharon A. Townson, Joseph T. Kovalchin, Allyson Masci, Olga Kiner, Yanqun Shu, Bracken M. King, Emily Schirmer, Kathryn Golden, Christoph Thomas, K. Christopher Garcia, Gregory Zarbis-Papastoitsis, Eric S. Furfine, and Thomas M. Barnes

    PNAS March 5, 2013 110 (10) 3913-3918; https://doi.org/10.1073/pnas.1217996110
  • Open Access

    Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

    Fabienne Guillaumond, Julie Leca, Orianne Olivares, Marie-Noëlle Lavaut, Nicolas Vidal, Patrice Berthezène, Nelson Javier Dusetti, Céline Loncle, Ezequiel Calvo, Olivier Turrini, Juan Lucio Iovanna, Richard Tomasini, and Sophie Vasseur

    PNAS March 5, 2013 110 (10) 3919-3924; https://doi.org/10.1073/pnas.1219555110
  • Open Access

    Avalanche-like behavior in ciliary import

    William B. Ludington, Kimberly A. Wemmer, Karl F. Lechtreck, George B. Witman, and Wallace F. Marshall

    PNAS March 5, 2013 110 (10) 3925-3930; https://doi.org/10.1073/pnas.1217354110
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    DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions

    Alessandra Insinga, Angelo Cicalese, Mario Faretta, Barbara Gallo, Luisa Albano, Simona Ronzoni, Laura Furia, Andrea Viale, and Pier Giuseppe Pelicci

    PNAS March 5, 2013 110 (10) 3931-3936; https://doi.org/10.1073/pnas.1213394110
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    Direct reprogramming by oncogenic Ras and Myc

    Irene Ischenko, Jizu Zhi, Ute M. Moll, Alice Nemajerova, and Oleksi Petrenko

    PNAS March 5, 2013 110 (10) 3937-3942; https://doi.org/10.1073/pnas.1219592110

• Developmental Biology

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    Responses of hair follicle–associated structures to loss of planar cell polarity signaling

    Hao Chang and Jeremy Nathans

    PNAS March 5, 2013 110 (10) E908-E917; https://doi.org/10.1073/pnas.1301430110
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    Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma

    Michael Chiorazzi, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W. Maurer, Stella M. Ranuncolo, Hong Zhao, Weihong Xu, Wing-Chung C. Chan, Elaine S. Jaffe, Randy D. Gascoyne, Elias Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M. Rimsza, Shai Shaham, and Louis M. Staudt

    PNAS March 5, 2013 110 (10) 3943-3948; https://doi.org/10.1073/pnas.1217271110

• Ecology

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    The steady-state mosaic of disturbance and succession across an old-growth Central Amazon forest landscape

    • From the Cover

    Jeffrey Q. Chambers, Robinson I. Negron-Juarez, Daniel Magnabosco Marra, Alan Di Vittorio, Joerg Tews, Dar Roberts, Gabriel H. P. M. Ribeiro, Susan E. Trumbore, and Niro Higuchi

    PNAS March 5, 2013 110 (10) 3949-3954; https://doi.org/10.1073/pnas.1202894110

    See companion article:

    • Forest disturbance

      - Feb 20, 2013

• Evolution

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    Variants at serotonin transporter and 2A receptor genes predict cooperative behavior differentially according to presence of punishment

    Kari B. Schroeder, Richard McElreath, and Daniel Nettle

    PNAS March 5, 2013 110 (10) 3955-3960; https://doi.org/10.1073/pnas.1216841110
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    Long prereproductive selection and divergence by depth in a Caribbean candelabrum coral

    Carlos Prada and Michael E. Hellberg

    PNAS March 5, 2013 110 (10) 3961-3966; https://doi.org/10.1073/pnas.1208931110

    See companion article:

    • Diversification in the sea

      - Feb 14, 2013
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    Functional consequences of sequence variation in the pheromone biosynthetic gene pgFAR for Ostrinia moths

    Jean-Marc Lassance, Marjorie A. Liénard, Binu Antony, Shuguang Qian, Takeshi Fujii, Jun Tabata, Yukio Ishikawa, and Christer Löfstedt

    PNAS March 5, 2013 110 (10) 3967-3972; https://doi.org/10.1073/pnas.1208706110
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    Plant mating system transitions drive the macroevolution of defense strategies

    Stuart A. Campbell and André Kessler

    PNAS March 5, 2013 110 (10) 3973-3978; https://doi.org/10.1073/pnas.1213867110

• Genetics

  • Open Access

    Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos

    Soyoung Kim, Takao Ishidate, Rita Sharma, Martha C. Soto, Darryl Conte Jr., Craig C. Mello, and Masaki Shirayama

    PNAS March 5, 2013 110 (10) E918-E927; https://doi.org/10.1073/pnas.1300769110
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    Anatomical and transcriptional dynamics of maize embryonic leaves during seed germination

    Wen-Yu Liu, Yao-Ming Chang, Sean Chun-Chang Chen, Chen-Hua Lu, Yeh-Hwa Wu, Mei-Yeh Jade Lu, Di-Rong Chen, Arthur Chun-Chieh Shih, Chiou-Rong Sheue, Hsuan-Cheng Huang, Chun-Ping Yu, Hsin-Hung Lin, Shin-Han Shiu, Maurice Sun-Ben Ku, and Wen-Hsiung Li

    PNAS March 5, 2013 110 (10) 3979-3984; https://doi.org/10.1073/pnas.1301009110
  • Open Access

    Rare variant detection using family-based sequencing analysis

    Gang Peng, Yu Fan, Timothy B. Palculict, Peidong Shen, E. Cristy Ruteshouser, Aung-Kyaw Chi, Ronald W. Davis, Vicki Huff, Curt Scharfe, and Wenyi Wang

    PNAS March 5, 2013 110 (10) 3985-3990; https://doi.org/10.1073/pnas.1222158110

• Medical Sciences

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    Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target

    Liaquat S. Verjee, Jennifer S. N. Verhoekx, James K. K. Chan, Thomas Krausgruber, Vicky Nicolaidou, David Izadi, Dominique Davidson, Marc Feldmann, Kim S. Midwood, and Jagdeep Nanchahal

    PNAS March 5, 2013 110 (10) E928-E937; https://doi.org/10.1073/pnas.1301100110
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    Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

    Jeremie Guedj, Harel Dahari, Libin Rong, Natasha D. Sansone, Richard E. Nettles, Scott J. Cotler, Thomas J. Layden, Susan L. Uprichard, and Alan S. Perelson

    PNAS March 5, 2013 110 (10) 3991-3996; https://doi.org/10.1073/pnas.1203110110
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    Engineering of a functional bone organ through endochondral ossification

    Celeste Scotti, Elia Piccinini, Hitoshi Takizawa, Atanas Todorov, Paul Bourgine, Adam Papadimitropoulos, Andrea Barbero, Markus G. Manz, and Ivan Martin

    PNAS March 5, 2013 110 (10) 3997-4002; https://doi.org/10.1073/pnas.1220108110
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    Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration

    Arun K. Sharma, Matthew I. Bury, Natalie J. Fuller, Andrew J. Marks, David M. Kollhoff, Manoj V. Rao, Partha V. Hota, Derek J. Matoka, Seby L. Edassery, Hatim Thaker, John F. Sarwark, Joseph A. Janicki, Guillermo A. Ameer, and Earl Y. Cheng

    PNAS March 5, 2013 110 (10) 4003-4008; https://doi.org/10.1073/pnas.1220764110
  • Open Access

    Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

    Andrea Sottoriva, Inmaculada Spiteri, Sara G. M. Piccirillo, Anestis Touloumis, V. Peter Collins, John C. Marioni, Christina Curtis, Colin Watts, and Simon Tavaré

    PNAS March 5, 2013 110 (10) 4009-4014; https://doi.org/10.1073/pnas.1219747110
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    Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo

    Christian Posch, Homayoun Moslehi, Luzviminda Feeney, Gary A. Green, Anoosheh Ebaee, Valentin Feichtenschlager, Kim Chong, Lily Peng, Michelle T. Dimon, Thomas Phillips, Adil I. Daud, Timothy H. McCalmont, Philip E. LeBoit, and Susana Ortiz-Urda

    PNAS March 5, 2013 110 (10) 4015-4020; https://doi.org/10.1073/pnas.1216013110

• Microbiology

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    Mechanistic link between β barrel assembly and the initiation of autotransporter secretion

    Olga Pavlova, Janine H. Peterson, Raffaele Ieva, and Harris D. Bernstein

    PNAS March 5, 2013 110 (10) E938-E947; https://doi.org/10.1073/pnas.1219076110
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    Engineering furfural tolerance in Escherichia coli improves the fermentation of lignocellulosic sugars into renewable chemicals

    Xuan Wang, Lorraine P. Yomano, James Y. Lee, Sean W. York, Huabao Zheng, Michael T. Mullinnix, K. T. Shanmugam, and Lonnie O. Ingram

    PNAS March 5, 2013 110 (10) 4021-4026; https://doi.org/10.1073/pnas.1217958110

• Neuroscience

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    The δ2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites

    Kazuhisa Kohda, Wataru Kakegawa, Shinji Matsuda, Tadashi Yamamoto, Hisashi Hirano, and Michisuke Yuzaki

    PNAS March 5, 2013 110 (10) E948-E957; https://doi.org/10.1073/pnas.1218380110
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    Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

    Sadegh Nabavi, Helmut W. Kessels, Stephanie Alfonso, Jonathan Aow, Rocky Fox, and Roberto Malinow

    PNAS March 5, 2013 110 (10) 4027-4032; https://doi.org/10.1073/pnas.1219454110

    See companion article:

    • Effects of β-amyloid on NMDA receptor function

      - Feb 19, 2013
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    Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression

    Helmut W. Kessels, Sadegh Nabavi, and Roberto Malinow

    PNAS March 5, 2013 110 (10) 4033-4038; https://doi.org/10.1073/pnas.1219605110

    See companion article:

    • Metabotropic NMDA receptor function in LTD

      - Feb 19, 2013
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    DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

    Trent A. Watkins, Bei Wang, Sarah Huntwork-Rodriguez, Jing Yang, Zhiyu Jiang, Jeffrey Eastham-Anderson, Zora Modrusan, Joshua S. Kaminker, Marc Tessier-Lavigne, and Joseph W. Lewcock

    PNAS March 5, 2013 110 (10) 4039-4044; https://doi.org/10.1073/pnas.1211074110

    See companion article:

    • Identification of DLK as a mediator of RGC death

      - Feb 19, 2013
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    Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

    Derek S. Welsbie, Zhiyong Yang, Yan Ge, Katherine L. Mitchell, Xinrong Zhou, Scott E. Martin, Cynthia A. Berlinicke, Laszlo Hackler Jr., John Fuller, Jie Fu, Li-hui Cao, Bing Han, Douglas Auld, Tian Xue, Syu-ichi Hirai, Lucie Germain, Caroline Simard-Bisson, Richard Blouin, Judy V. Nguyen, Chung-ha O. Davis, Raymond A. Enke, Sanford L. Boye, Shannath L. Merbs, Nicholas Marsh-Armstrong, William W. Hauswirth, Aaron DiAntonio, Robert W. Nickells, James Inglese, Justin Hanes, King-Wai Yau, Harry A. Quigley, and Donald J. Zack

    PNAS March 5, 2013 110 (10) 4045-4050; https://doi.org/10.1073/pnas.1211284110

    See companion article:

    • DLK regulates apoptosis and regeneration

      - Feb 19, 2013
  • You have access

    Spatial mismatch between the Na⁺ flux and spike initiation in axon initial segment

    • From the Cover

    Gytis Baranauskas, Yaron David, and Ilya A. Fleidervish

    PNAS March 5, 2013 110 (10) 4051-4056; https://doi.org/10.1073/pnas.1215125110

    See companion article:

    • Cable properties and action potential initiation

      - Feb 25, 2013
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    Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases

    • From the Cover

    Yeong Shin Yim, Younghee Kwon, Jungyong Nam, Hong In Yoon, Kangduk Lee, Dong Goo Kim, Eunjoon Kim, Chul Hoon Kim, and Jaewon Ko

    PNAS March 5, 2013 110 (10) 4057-4062; https://doi.org/10.1073/pnas.1209881110

    See companion article:

    • PTPs and Slitrks in synaptogenesis

      - Feb 20, 2013
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    Ambient noise induces independent shifts in call frequency and amplitude within the Lombard effect in echolocating bats

    • From the Cover

    Steffen R. Hage, Tinglei Jiang, Sean W. Berquist, Jiang Feng, and Walter Metzner

    PNAS March 5, 2013 110 (10) 4063-4068; https://doi.org/10.1073/pnas.1211533110
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    Reactive astrocytes secrete lcn2 to promote neuron death

    Fangfang Bi, Cao Huang, Jianbin Tong, Guang Qiu, Bo Huang, Qinxue Wu, Fang Li, Zuoshang Xu, Robert Bowser, Xu-Gang Xia, and Hongxia Zhou

    PNAS March 5, 2013 110 (10) 4069-4074; https://doi.org/10.1073/pnas.1218497110
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    Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelin

    Berit E. Powers, Drew L. Sellers, Emilie A. Lovelett, Willy Cheung, Sheida P. Aalami, Nikolai Zapertov, Don O. Maris, and Philip J. Horner

    PNAS March 5, 2013 110 (10) 4075-4080; https://doi.org/10.1073/pnas.1210293110
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    The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map

    Gina E. Elsen, Rebecca D. Hodge, Francesco Bedogni, Ray A. M. Daza, Branden R. Nelson, Naoko Shiba, Steven L. Reiner, and Robert F. Hevner

    PNAS March 5, 2013 110 (10) 4081-4086; https://doi.org/10.1073/pnas.1209076110
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    Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

    Bong-Kyu Choi, Mal-Gi Choi, Jae-Yeol Kim, Yoosoo Yang, Ying Lai, Dae-Hyuk Kweon, Nam Ki Lee, and Yeon-Kyun Shin

    PNAS March 5, 2013 110 (10) 4087-4092; https://doi.org/10.1073/pnas.1218424110
  • Open Access

    Dorsolateral caudate nucleus differentiates cocaine from natural reward-associated contextual cues

    Hua-Shan Liu, Svetlana Chefer, Hanbing Lu, Karine Guillem, William Rea, Pradeep Kurup, Yihong Yang, Laura Peoples, and Elliot A. Stein

    PNAS March 5, 2013 110 (10) 4093-4098; https://doi.org/10.1073/pnas.1207531110

• Pharmacology

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    Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure

    Kamel Maouche, Kahina Medjber, Jean-Marie Zahm, Franck Delavoie, Christine Terryn, Christelle Coraux, Stéphanie Pons, Isabelle Cloëz-Tayarani, Uwe Maskos, Philippe Birembaut, and Jean-Marie Tournier

    PNAS March 5, 2013 110 (10) 4099-4104; https://doi.org/10.1073/pnas.1216939110

• Physiology

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    Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics

    Marie A. Schroeder, Mohammad A. Ali, Alzbeta Hulikova, Claudiu T. Supuran, Kieran Clarke, Richard D. Vaughan-Jones, Damian J. Tyler, and Pawel Swietach

    PNAS March 5, 2013 110 (10) E958-E967; https://doi.org/10.1073/pnas.1213471110
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    Convergence of IRBIT, phosphatidylinositol (4,5) bisphosphate, and WNK/SPAK kinases in regulation of the Na⁺-HCO₃⁻ cotransporters family

    Jeong Hee Hong, Dongki Yang, Nikolay Shcheynikov, Ehud Ohana, Dong Min Shin, and Shmuel Muallem

    PNAS March 5, 2013 110 (10) 4105-4110; https://doi.org/10.1073/pnas.1221410110

• Plant Biology

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    Flavodiiron proteins Flv1 and Flv3 enable cyanobacterial growth and photosynthesis under fluctuating light

    Yagut Allahverdiyeva, Henna Mustila, Maria Ermakova, Luca Bersanini, Pierre Richaud, Ghada Ajlani, Natalia Battchikova, Laurent Cournac, and Eva-Mari Aro

    PNAS March 5, 2013 110 (10) 4111-4116; https://doi.org/10.1073/pnas.1221194110
  • Open Access

    3′ fragment of miR173-programmed RISC-cleaved RNA is protected from degradation in a complex with RISC and SGS3

    Manabu Yoshikawa, Taichiro Iki, Yasuhiro Tsutsui, Kyoko Miyashita, R. Scott Poethig, Yoshiki Habu, and Masayuki Ishikawa

    PNAS March 5, 2013 110 (10) 4117-4122; https://doi.org/10.1073/pnas.1217050110

• Psychological and Cognitive Sciences

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    Evidence suggesting that desire-state attribution may govern food sharing in Eurasian jays

    • From the Cover

    Ljerka Ostojić, Rachael C. Shaw, Lucy G. Cheke, and Nicola S. Clayton

    PNAS March 5, 2013 110 (10) 4123-4128; https://doi.org/10.1073/pnas.1209926110

    See companion article:

    • Eurasian jays predict mates’ food preferences

      - Feb 20, 2013
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    Stress increases aversive prediction error signal in the ventral striatum

    Oliver J. Robinson, Cassie Overstreet, Danielle R. Charney, Katherine Vytal, and Christian Grillon

    PNAS March 5, 2013 110 (10) 4129-4133; https://doi.org/10.1073/pnas.1213923110

• Sustainability Science

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    Recent land use change in the Western Corn Belt threatens grasslands and wetlands

    Christopher K. Wright and Michael C. Wimberly

    PNAS March 5, 2013 110 (10) 4134-4139; https://doi.org/10.1073/pnas.1215404110

    See companion article:

    • CDL provides valid estimates of grassland change

      - Jun 10, 2013

• Systems Biology

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    Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program

    Xin Guo, Allister Bernard, David A. Orlando, Steven B. Haase, and Alexander J. Hartemink

    PNAS March 5, 2013 110 (10) E968-E977; https://doi.org/10.1073/pnas.1120991110
  • Open Access

    Rate of environmental change determines stress response specificity

    Jonathan W. Young, James C. W. Locke, and Michael B. Elowitz

    PNAS March 5, 2013 110 (10) 4140-4145; https://doi.org/10.1073/pnas.1213060110