Proceedings of the National Academy of Sciences: 110 (10)

New Research In

March 05, 2013; vol. 110 no. 10

This Week in PNAS

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In This Issue
PNAS March 5, 2013 110 (10) 3701-3702; https://doi.org/10.1073/iti1013110

Letters (Online Only)

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Proteome size as the major factor determining mutation rates
Steven E. Massey

PNAS March 5, 2013 110 (10) E858-E859; https://doi.org/10.1073/pnas.1219306110
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Reply to Massey: Drift does influence mutation-rate evolution
Way Sung, Matthew S. Ackerman, Samuel F. Miller, Thomas G. Doak, and Michael Lynch

PNAS March 5, 2013 110 (10) E860; https://doi.org/10.1073/pnas.1220650110

News Feature

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Agents of influence
Front Matter
Robert Frederick

PNAS March 5, 2013 110 (10) 3703-3705; https://doi.org/10.1073/pnas.1302005110

Science and Culture

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Curved-crease sculpture
Front Matter
Nicholette Zeliadt

PNAS March 5, 2013 110 (10) 3706; https://doi.org/10.1073/pnas.1302489110

Retrospective

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Elwood V. Jensen (1920–2012): Father of the nuclear receptors
Bert W. O’Malley and Sohaib Khan

PNAS March 5, 2013 110 (10) 3707-3708; https://doi.org/10.1073/pnas.1301566110

Inner Workings

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Deep cleaning
Front Matter
Danielle Venton

PNAS March 5, 2013 110 (10) 3709; https://doi.org/10.1073/pnas.1302491110

Core Concepts

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Giant magnetoresistance
Front Matter
Stephen Ornes

PNAS March 5, 2013 110 (10) 3710; https://doi.org/10.1073/pnas.1302494110

Commentaries

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Geography of forest disturbance
Gregory P. Asner

PNAS March 5, 2013 110 (10) 3711-3712; https://doi.org/10.1073/pnas.1300396110
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Inviable immigrants drive diversification in the sea
David W. Pfennig

PNAS March 5, 2013 110 (10) 3713-3714; https://doi.org/10.1073/pnas.1300517110
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Reemerging role of cable properties in action potential initiation
Yunyong Ma and John R. Huguenard

PNAS March 5, 2013 110 (10) 3715-3716; https://doi.org/10.1073/pnas.1300520110
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Why we need more synaptogenic cell-adhesion proteins
Nils Brose

PNAS March 5, 2013 110 (10) 3717-3718; https://doi.org/10.1073/pnas.1300505110
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Eurasian jays predict the food preferences of their mates
Alan C. Kamil

PNAS March 5, 2013 110 (10) 3719-3720; https://doi.org/10.1073/pnas.1300515110

PNAS Plus Significance Statements

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PNAS Plus Significance Statements
PNAS March 5, 2013 110 (10) 3721-3722; https://doi.org/10.1073/pnas.ss11010

Physical Sciences

Applied Mathematics
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  Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism
  Paul François, Guillaume Voisinne, Eric D. Siggia, Grégoire Altan-Bonnet, and Massimo Vergassola
  
  PNAS March 5, 2013 110 (10) E888-E897; https://doi.org/10.1073/pnas.1300752110
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  Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
  Jeremie Guedj, Harel Dahari, Libin Rong, Natasha D. Sansone, Richard E. Nettles, Scott J. Cotler, Thomas J. Layden, Susan L. Uprichard, and Alan S. Perelson
  
  PNAS March 5, 2013 110 (10) 3991-3996; https://doi.org/10.1073/pnas.1203110110
Applied Physical Sciences
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  Surface layering and melting in an ionic liquid studied by resonant soft X-ray reflectivity
  Markus Mezger, Benjamin M. Ocko, Harald Reichert, and Moshe Deutsch
  
  PNAS March 5, 2013 110 (10) 3733-3737; https://doi.org/10.1073/pnas.1211749110
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  Coupling the valley degree of freedom to antiferromagnetic order
  Xiao Li, Ting Cao, Qian Niu, Junren Shi, and Ji Feng
  
  PNAS March 5, 2013 110 (10) 3738-3742; https://doi.org/10.1073/pnas.1219420110
Chemistry
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  Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species
  Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Jung-Suk Choi, Ayyalusamy Ramamoorthy, Brandon T. Ruotolo, and Mi Hee Lim
  
  PNAS March 5, 2013 110 (10) 3743-3748; https://doi.org/10.1073/pnas.1220326110
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  Synthesis of an extra-large molecular sieve using proton sponges as organic structure-directing agents
  Raquel Martínez-Franco, Manuel Moliner, Yifeng Yun, Junliang Sun, Wei Wan, Xiaodong Zou, and Avelino Corma
  
  PNAS March 5, 2013 110 (10) 3749-3754; https://doi.org/10.1073/pnas.1220733110
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  Elasticity, structure, and relaxation of extended proteins under force
  Guillaume Stirnemann, David Giganti, Julio M. Fernandez, and B. J. Berne
  
  PNAS March 5, 2013 110 (10) 3847-3852; https://doi.org/10.1073/pnas.1300596110
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Real-time 3D imaging of Haines jumps in porous media flow
  Steffen Berg, Holger Ott, Stephan A. Klapp, Alex Schwing, Rob Neiteler, Niels Brussee, Axel Makurat, Leon Leu, Frieder Enzmann, Jens-Oliver Schwarz, Michael Kersten, Sarah Irvine, and Marco Stampanoni
  
  PNAS March 5, 2013 110 (10) 3755-3759; https://doi.org/10.1073/pnas.1221373110
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  Worldwide data sets constrain the water vapor uptake coefficient in cloud formation
  Tomi Raatikainen, Athanasios Nenes, John H. Seinfeld, Ricardo Morales, Richard H. Moore, Terry L. Lathem, Sara Lance, Luz T. Padró, Jack J. Lin, Kate M. Cerully, Aikaterini Bougiatioti, Julie Cozic, Christopher R. Ruehl, Patrick Y. Chuang, Bruce E. Anderson, Richard C. Flagan, Haflidi Jonsson, Nikos Mihalopoulos, and James N. Smith
  
  PNAS March 5, 2013 110 (10) 3760-3764; https://doi.org/10.1073/pnas.1219591110
Environmental Sciences
- Open Access
  Proteomic analysis of skeletal organic matrix from the stony coral Stylophora pistillata
  Jeana L. Drake, Tali Mass, Liti Haramaty, Ehud Zelzion, Debashish Bhattacharya, and Paul G. Falkowski
  
  PNAS March 5, 2013 110 (10) 3788-3793; https://doi.org/10.1073/pnas.1301419110
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  The steady-state mosaic of disturbance and succession across an old-growth Central Amazon forest landscape
  From the Cover
  
  Jeffrey Q. Chambers, Robinson I. Negron-Juarez, Daniel Magnabosco Marra, Alan Di Vittorio, Joerg Tews, Dar Roberts, Gabriel H. P. M. Ribeiro, Susan E. Trumbore, and Niro Higuchi
  
  PNAS March 5, 2013 110 (10) 3949-3954; https://doi.org/10.1073/pnas.1202894110
Physics
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  Experimental demonstration of radicaloid character in a Ru^V=O intermediate in catalytic water oxidation
  Dooshaye Moonshiram, Igor Alperovich, Javier J. Concepcion, Thomas J. Meyer, and Yulia Pushkar
  
  PNAS March 5, 2013 110 (10) 3765-3770; https://doi.org/10.1073/pnas.1222102110
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  Relation between ordering and shear thinning in colloidal suspensions
  Xinliang Xu, Stuart A. Rice, and Aaron R. Dinner
  
  PNAS March 5, 2013 110 (10) 3771-3776; https://doi.org/10.1073/pnas.1301055110
- Open Access
  Opening up three quantum boxes causes classically undetectable wavefunction collapse
  Richard E. George, Lucio M. Robledo, Owen J. E. Maroney, Machiel S. Blok, Hannes Bernien, Matthew L. Markham, Daniel J. Twitchen, John J. L. Morton, G. Andrew D. Briggs, and Ronald Hanson
  
  PNAS March 5, 2013 110 (10) 3777-3781; https://doi.org/10.1073/pnas.1208374110
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  Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations
  Christian Westendorf, Jose Negrete Jr., Albert J. Bae, Rabea Sandmann, Eberhard Bodenschatz, and Carsten Beta
  
  PNAS March 5, 2013 110 (10) 3853-3858; https://doi.org/10.1073/pnas.1216629110

Biological Sciences

Applied Biological Sciences
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  Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides
  Benedikt Wefers, Melanie Meyer, Oskar Ortiz, Martin Hrabé de Angelis, Jens Hansen, Wolfgang Wurst, and Ralf Kühn
  
  PNAS March 5, 2013 110 (10) 3782-3787; https://doi.org/10.1073/pnas.1218721110
Biochemistry
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  Nascent peptides that block protein synthesis in bacteria
  Christopher J. Woolstenhulme, Shankar Parajuli, David W. Healey, Diana P. Valverde, E. Nicholas Petersen, Agata L. Starosta, Nicholas R. Guydosh, W. Evan Johnson, Daniel N. Wilson, and Allen R. Buskirk
  
  PNAS March 5, 2013 110 (10) E878-E887; https://doi.org/10.1073/pnas.1219536110
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  Host–rabies virus protein–protein interactions as druggable antiviral targets
  Usha F. Lingappa, Xianfu Wu, Amanda Macieik, Shao Feng Yu, Andy Atuegbu, Michael Corpuz, Jean Francis, Christine Nichols, Alfredo Calayag, Hong Shi, James A. Ellison, Emma K. T. Harrell, Vinod Asundi, Jaisri R. Lingappa, M. Dharma Prasad, W. Ian Lipkin, Debendranath Dey, Clarence R. Hurt, Vishwanath R. Lingappa, William J. Hansen, and Charles E. Rupprecht
  
  PNAS March 5, 2013 110 (10) E861-E868; https://doi.org/10.1073/pnas.1210198110
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  Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters
  Birgit Dreier, Annemarie Honegger, Christian Hess, Gabriela Nagy-Davidescu, Peer R. E. Mittl, Markus G. Grütter, Natalya Belousova, Galina Mikheeva, Victor Krasnykh, and Andreas Plückthun
  
  PNAS March 5, 2013 110 (10) E869-E877; https://doi.org/10.1073/pnas.1213653110
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  Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species
  Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Jung-Suk Choi, Ayyalusamy Ramamoorthy, Brandon T. Ruotolo, and Mi Hee Lim
  
  PNAS March 5, 2013 110 (10) 3743-3748; https://doi.org/10.1073/pnas.1220326110
- Open Access
  Proteomic analysis of skeletal organic matrix from the stony coral Stylophora pistillata
  Jeana L. Drake, Tali Mass, Liti Haramaty, Ehud Zelzion, Debashish Bhattacharya, and Paul G. Falkowski
  
  PNAS March 5, 2013 110 (10) 3788-3793; https://doi.org/10.1073/pnas.1301419110
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  Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits
  PuiYee Chan, Celestine J. Thomas, Stephen R. Sprang, and Gregory G. Tall
  
  PNAS March 5, 2013 110 (10) 3794-3799; https://doi.org/10.1073/pnas.1220943110
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  UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy
  Takafumi Tasaki, Sung Tae Kim, Adriana Zakrzewska, Bo Eun Lee, Min Jueng Kang, Young Dong Yoo, Hyun Joo Cha-Molstad, Joonsung Hwang, Nak Kyun Soung, Ki Sa Sung, Su-Hyeon Kim, Minh Dang Nguyen, Ming Sun, Eugene C. Yi, Bo Yeon Kim, and Yong Tae Kwon
  
  PNAS March 5, 2013 110 (10) 3800-3805; https://doi.org/10.1073/pnas.1217358110
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  Crystal structure of microsomal prostaglandin E₂ synthase provides insight into diversity in the MAPEG superfamily
  Tove Sjögren, Johan Nord, Margareta Ek, Patrik Johansson, Gang Liu, and Stefan Geschwindner
  
  PNAS March 5, 2013 110 (10) 3806-3811; https://doi.org/10.1073/pnas.1218504110
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  Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis
  Lasse Jenner, Agata L. Starosta, Daniel S. Terry, Aleksandra Mikolajka, Liudmila Filonava, Marat Yusupov, Scott C. Blanchard, Daniel N. Wilson, and Gulnara Yusupova
  
  PNAS March 5, 2013 110 (10) 3812-3816; https://doi.org/10.1073/pnas.1216691110
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  Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens
  Li Li, Andrés Palencia, Tiit Lukk, Zhi Li, Zaida A. Luthey-Schulten, Stephen Cusack, Susan A. Martinis, and Michal T. Boniecki
  
  PNAS March 5, 2013 110 (10) 3817-3822; https://doi.org/10.1073/pnas.1218374110
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  The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes
  Henning J. kleine Balderhaar, Jens Lachmann, Erdal Yavavli, Cornelia Bröcker, Anna Lürick, and Christian Ungermann
  
  PNAS March 5, 2013 110 (10) 3823-3828; https://doi.org/10.1073/pnas.1221785110
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  Global structural motions from the strain of a single hydrogen bond
  Jens Danielsson, Wael Awad, Kadhirvel Saraboji, Martin Kurnik, Lisa Lang, Lina Leinartaitė, Stefan L. Marklund, Derek T. Logan, and Mikael Oliveberg
  
  PNAS March 5, 2013 110 (10) 3829-3834; https://doi.org/10.1073/pnas.1217306110
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  Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase
  Ellen C. Minnihan, Nozomi Ando, Edward J. Brignole, Lisa Olshansky, Johnathan Chittuluru, Francisco J. Asturias, Catherine L. Drennan, Daniel G. Nocera, and JoAnne Stubbe
  
  PNAS March 5, 2013 110 (10) 3835-3840; https://doi.org/10.1073/pnas.1220691110
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  Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens
  Steven M. Damo, Thomas E. Kehl-Fie, Norie Sugitani, Marilyn E. Holt, Subodh Rathi, Wesley J. Murphy, Yaofang Zhang, Christine Betz, Laura Hench, Günter Fritz, Eric P. Skaar, and Walter J. Chazin
  
  PNAS March 5, 2013 110 (10) 3841-3846; https://doi.org/10.1073/pnas.1220341110
Biophysics and Computational Biology
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  Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism
  Paul François, Guillaume Voisinne, Eric D. Siggia, Grégoire Altan-Bonnet, and Massimo Vergassola
  
  PNAS March 5, 2013 110 (10) E888-E897; https://doi.org/10.1073/pnas.1300752110
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  Elasticity, structure, and relaxation of extended proteins under force
  Guillaume Stirnemann, David Giganti, Julio M. Fernandez, and B. J. Berne
  
  PNAS March 5, 2013 110 (10) 3847-3852; https://doi.org/10.1073/pnas.1300596110
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  Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations
  Christian Westendorf, Jose Negrete Jr., Albert J. Bae, Rabea Sandmann, Eberhard Bodenschatz, and Carsten Beta
  
  PNAS March 5, 2013 110 (10) 3853-3858; https://doi.org/10.1073/pnas.1216629110
- Open Access
  Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching using fluorescence microscopy
  Graeme A. King, Peter Gross, Ulrich Bockelmann, Mauro Modesti, Gijs J. L. Wuite, and Erwin J. G. Peterman
  
  PNAS March 5, 2013 110 (10) 3859-3864; https://doi.org/10.1073/pnas.1213676110
- Open Access
  Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry
  Xinghua Zhang, Hu Chen, Shimin Le, Ioulia Rouzina, Patrick S. Doyle, and Jie Yan
  
  PNAS March 5, 2013 110 (10) 3865-3870; https://doi.org/10.1073/pnas.1213740110
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  SOD1 exhibits allosteric frustration to facilitate metal binding affinity
  Atanu Das and Steven S. Plotkin
  
  PNAS March 5, 2013 110 (10) 3871-3876; https://doi.org/10.1073/pnas.1216597110
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  eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition
  Michael J. Osborne, Laurent Volpon, Jack A. Kornblatt, Biljana Culjkovic-Kraljacic, Aurélie Baguet, and Katherine L. B. Borden
  
  PNAS March 5, 2013 110 (10) 3877-3882; https://doi.org/10.1073/pnas.1216862110
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  Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5
  Lei Song and Joseph Santos-Sacchi
  
  PNAS March 5, 2013 110 (10) 3883-3888; https://doi.org/10.1073/pnas.1218341110
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  Structure of Sr-substituted photosystem II at 2.1 Å resolution and its implications in the mechanism of water oxidation
  Faisal Hammad Mekky Koua, Yasufumi Umena, Keisuke Kawakami, and Jian-Ren Shen
  
  PNAS March 5, 2013 110 (10) 3889-3894; https://doi.org/10.1073/pnas.1219922110
Cell Biology
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  Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis
  Mara Schvarzstein, Divya Pattabiraman, Joshua N. Bembenek, and Anne M. Villeneuve
  
  PNAS March 5, 2013 110 (10) E898-E907; https://doi.org/10.1073/pnas.1213888110
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  MOZ increases p53 acetylation and premature senescence through its complex formation with PML
  Susumu Rokudai, Oleg Laptenko, Suzzette M. Arnal, Yoichi Taya, Issay Kitabayashi, and Carol Prives
  
  PNAS March 5, 2013 110 (10) 3895-3900; https://doi.org/10.1073/pnas.1300490110
- Open Access
  Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
  Eric Wang, Shinpei Kawaoka, Ming Yu, Junwei Shi, Ting Ni, Wenjing Yang, Jun Zhu, Robert G. Roeder, and Christopher R. Vakoc
  
  PNAS March 5, 2013 110 (10) 3901-3906; https://doi.org/10.1073/pnas.1301045110
- Open Access
  Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel
  Liang Jin, Tao Feng, Hung Ping Shih, Ricardo Zerda, Angela Luo, Jasper Hsu, Alborz Mahdavi, Maike Sander, David A. Tirrell, Arthur D. Riggs, and Hsun Teresa Ku
  
  PNAS March 5, 2013 110 (10) 3907-3912; https://doi.org/10.1073/pnas.1301889110
- Open Access
  Design of a superior cytokine antagonist for topical ophthalmic use
  Jinzhao Hou, Sharon A. Townson, Joseph T. Kovalchin, Allyson Masci, Olga Kiner, Yanqun Shu, Bracken M. King, Emily Schirmer, Kathryn Golden, Christoph Thomas, K. Christopher Garcia, Gregory Zarbis-Papastoitsis, Eric S. Furfine, and Thomas M. Barnes
  
  PNAS March 5, 2013 110 (10) 3913-3918; https://doi.org/10.1073/pnas.1217996110
- Open Access
  Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
  Fabienne Guillaumond, Julie Leca, Orianne Olivares, Marie-Noëlle Lavaut, Nicolas Vidal, Patrice Berthezène, Nelson Javier Dusetti, Céline Loncle, Ezequiel Calvo, Olivier Turrini, Juan Lucio Iovanna, Richard Tomasini, and Sophie Vasseur
  
  PNAS March 5, 2013 110 (10) 3919-3924; https://doi.org/10.1073/pnas.1219555110
- Open Access
  Avalanche-like behavior in ciliary import
  William B. Ludington, Kimberly A. Wemmer, Karl F. Lechtreck, George B. Witman, and Wallace F. Marshall
  
  PNAS March 5, 2013 110 (10) 3925-3930; https://doi.org/10.1073/pnas.1217354110
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  DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions
  Alessandra Insinga, Angelo Cicalese, Mario Faretta, Barbara Gallo, Luisa Albano, Simona Ronzoni, Laura Furia, Andrea Viale, and Pier Giuseppe Pelicci
  
  PNAS March 5, 2013 110 (10) 3931-3936; https://doi.org/10.1073/pnas.1213394110
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  Direct reprogramming by oncogenic Ras and Myc
  Irene Ischenko, Jizu Zhi, Ute M. Moll, Alice Nemajerova, and Oleksi Petrenko
  
  PNAS March 5, 2013 110 (10) 3937-3942; https://doi.org/10.1073/pnas.1219592110
Developmental Biology
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  Responses of hair follicle–associated structures to loss of planar cell polarity signaling
  Hao Chang and Jeremy Nathans
  
  PNAS March 5, 2013 110 (10) E908-E917; https://doi.org/10.1073/pnas.1301430110
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  Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma
  Michael Chiorazzi, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W. Maurer, Stella M. Ranuncolo, Hong Zhao, Weihong Xu, Wing-Chung C. Chan, Elaine S. Jaffe, Randy D. Gascoyne, Elias Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M. Rimsza, Shai Shaham, and Louis M. Staudt
  
  PNAS March 5, 2013 110 (10) 3943-3948; https://doi.org/10.1073/pnas.1217271110
Ecology
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  The steady-state mosaic of disturbance and succession across an old-growth Central Amazon forest landscape
  From the Cover
  
  Jeffrey Q. Chambers, Robinson I. Negron-Juarez, Daniel Magnabosco Marra, Alan Di Vittorio, Joerg Tews, Dar Roberts, Gabriel H. P. M. Ribeiro, Susan E. Trumbore, and Niro Higuchi
  
  PNAS March 5, 2013 110 (10) 3949-3954; https://doi.org/10.1073/pnas.1202894110
Evolution
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  Variants at serotonin transporter and 2A receptor genes predict cooperative behavior differentially according to presence of punishment
  Kari B. Schroeder, Richard McElreath, and Daniel Nettle
  
  PNAS March 5, 2013 110 (10) 3955-3960; https://doi.org/10.1073/pnas.1216841110
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  Long prereproductive selection and divergence by depth in a Caribbean candelabrum coral
  Carlos Prada and Michael E. Hellberg
  
  PNAS March 5, 2013 110 (10) 3961-3966; https://doi.org/10.1073/pnas.1208931110
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  Functional consequences of sequence variation in the pheromone biosynthetic gene pgFAR for Ostrinia moths
  Jean-Marc Lassance, Marjorie A. Liénard, Binu Antony, Shuguang Qian, Takeshi Fujii, Jun Tabata, Yukio Ishikawa, and Christer Löfstedt
  
  PNAS March 5, 2013 110 (10) 3967-3972; https://doi.org/10.1073/pnas.1208706110
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  Plant mating system transitions drive the macroevolution of defense strategies
  Stuart A. Campbell and André Kessler
  
  PNAS March 5, 2013 110 (10) 3973-3978; https://doi.org/10.1073/pnas.1213867110
Genetics
- Open Access
  Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos
  Soyoung Kim, Takao Ishidate, Rita Sharma, Martha C. Soto, Darryl Conte Jr., Craig C. Mello, and Masaki Shirayama
  
  PNAS March 5, 2013 110 (10) E918-E927; https://doi.org/10.1073/pnas.1300769110
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  Anatomical and transcriptional dynamics of maize embryonic leaves during seed germination
  Wen-Yu Liu, Yao-Ming Chang, Sean Chun-Chang Chen, Chen-Hua Lu, Yeh-Hwa Wu, Mei-Yeh Jade Lu, Di-Rong Chen, Arthur Chun-Chieh Shih, Chiou-Rong Sheue, Hsuan-Cheng Huang, Chun-Ping Yu, Hsin-Hung Lin, Shin-Han Shiu, Maurice Sun-Ben Ku, and Wen-Hsiung Li
  
  PNAS March 5, 2013 110 (10) 3979-3984; https://doi.org/10.1073/pnas.1301009110
- Open Access
  Rare variant detection using family-based sequencing analysis
  Gang Peng, Yu Fan, Timothy B. Palculict, Peidong Shen, E. Cristy Ruteshouser, Aung-Kyaw Chi, Ronald W. Davis, Vicki Huff, Curt Scharfe, and Wenyi Wang
  
  PNAS March 5, 2013 110 (10) 3985-3990; https://doi.org/10.1073/pnas.1222158110
Medical Sciences
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  Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target
  Liaquat S. Verjee, Jennifer S. N. Verhoekx, James K. K. Chan, Thomas Krausgruber, Vicky Nicolaidou, David Izadi, Dominique Davidson, Marc Feldmann, Kim S. Midwood, and Jagdeep Nanchahal
  
  PNAS March 5, 2013 110 (10) E928-E937; https://doi.org/10.1073/pnas.1301100110
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  Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
  Jeremie Guedj, Harel Dahari, Libin Rong, Natasha D. Sansone, Richard E. Nettles, Scott J. Cotler, Thomas J. Layden, Susan L. Uprichard, and Alan S. Perelson
  
  PNAS March 5, 2013 110 (10) 3991-3996; https://doi.org/10.1073/pnas.1203110110
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  Engineering of a functional bone organ through endochondral ossification
  Celeste Scotti, Elia Piccinini, Hitoshi Takizawa, Atanas Todorov, Paul Bourgine, Adam Papadimitropoulos, Andrea Barbero, Markus G. Manz, and Ivan Martin
  
  PNAS March 5, 2013 110 (10) 3997-4002; https://doi.org/10.1073/pnas.1220108110
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  Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration
  Arun K. Sharma, Matthew I. Bury, Natalie J. Fuller, Andrew J. Marks, David M. Kollhoff, Manoj V. Rao, Partha V. Hota, Derek J. Matoka, Seby L. Edassery, Hatim Thaker, John F. Sarwark, Joseph A. Janicki, Guillermo A. Ameer, and Earl Y. Cheng
  
  PNAS March 5, 2013 110 (10) 4003-4008; https://doi.org/10.1073/pnas.1220764110
- Open Access
  Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
  Andrea Sottoriva, Inmaculada Spiteri, Sara G. M. Piccirillo, Anestis Touloumis, V. Peter Collins, John C. Marioni, Christina Curtis, Colin Watts, and Simon Tavaré
  
  PNAS March 5, 2013 110 (10) 4009-4014; https://doi.org/10.1073/pnas.1219747110
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  Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo
  Christian Posch, Homayoun Moslehi, Luzviminda Feeney, Gary A. Green, Anoosheh Ebaee, Valentin Feichtenschlager, Kim Chong, Lily Peng, Michelle T. Dimon, Thomas Phillips, Adil I. Daud, Timothy H. McCalmont, Philip E. LeBoit, and Susana Ortiz-Urda
  
  PNAS March 5, 2013 110 (10) 4015-4020; https://doi.org/10.1073/pnas.1216013110
Microbiology
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  Mechanistic link between β barrel assembly and the initiation of autotransporter secretion
  Olga Pavlova, Janine H. Peterson, Raffaele Ieva, and Harris D. Bernstein
  
  PNAS March 5, 2013 110 (10) E938-E947; https://doi.org/10.1073/pnas.1219076110
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  Engineering furfural tolerance in Escherichia coli improves the fermentation of lignocellulosic sugars into renewable chemicals
  Xuan Wang, Lorraine P. Yomano, James Y. Lee, Sean W. York, Huabao Zheng, Michael T. Mullinnix, K. T. Shanmugam, and Lonnie O. Ingram
  
  PNAS March 5, 2013 110 (10) 4021-4026; https://doi.org/10.1073/pnas.1217958110
Neuroscience
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  The δ2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites
  Kazuhisa Kohda, Wataru Kakegawa, Shinji Matsuda, Tadashi Yamamoto, Hisashi Hirano, and Michisuke Yuzaki
  
  PNAS March 5, 2013 110 (10) E948-E957; https://doi.org/10.1073/pnas.1218380110
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  Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression
  Sadegh Nabavi, Helmut W. Kessels, Stephanie Alfonso, Jonathan Aow, Rocky Fox, and Roberto Malinow
  
  PNAS March 5, 2013 110 (10) 4027-4032; https://doi.org/10.1073/pnas.1219454110
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  Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression
  Helmut W. Kessels, Sadegh Nabavi, and Roberto Malinow
  
  PNAS March 5, 2013 110 (10) 4033-4038; https://doi.org/10.1073/pnas.1219605110
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  DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
  Trent A. Watkins, Bei Wang, Sarah Huntwork-Rodriguez, Jing Yang, Zhiyu Jiang, Jeffrey Eastham-Anderson, Zora Modrusan, Joshua S. Kaminker, Marc Tessier-Lavigne, and Joseph W. Lewcock
  
  PNAS March 5, 2013 110 (10) 4039-4044; https://doi.org/10.1073/pnas.1211074110
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  Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death
  Derek S. Welsbie, Zhiyong Yang, Yan Ge, Katherine L. Mitchell, Xinrong Zhou, Scott E. Martin, Cynthia A. Berlinicke, Laszlo Hackler Jr., John Fuller, Jie Fu, Li-hui Cao, Bing Han, Douglas Auld, Tian Xue, Syu-ichi Hirai, Lucie Germain, Caroline Simard-Bisson, Richard Blouin, Judy V. Nguyen, Chung-ha O. Davis, Raymond A. Enke, Sanford L. Boye, Shannath L. Merbs, Nicholas Marsh-Armstrong, William W. Hauswirth, Aaron DiAntonio, Robert W. Nickells, James Inglese, Justin Hanes, King-Wai Yau, Harry A. Quigley, and Donald J. Zack
  
  PNAS March 5, 2013 110 (10) 4045-4050; https://doi.org/10.1073/pnas.1211284110
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  Spatial mismatch between the Na⁺ flux and spike initiation in axon initial segment
  From the Cover
  
  Gytis Baranauskas, Yaron David, and Ilya A. Fleidervish
  
  PNAS March 5, 2013 110 (10) 4051-4056; https://doi.org/10.1073/pnas.1215125110
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  Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases
  From the Cover
  
  Yeong Shin Yim, Younghee Kwon, Jungyong Nam, Hong In Yoon, Kangduk Lee, Dong Goo Kim, Eunjoon Kim, Chul Hoon Kim, and Jaewon Ko
  
  PNAS March 5, 2013 110 (10) 4057-4062; https://doi.org/10.1073/pnas.1209881110
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  Ambient noise induces independent shifts in call frequency and amplitude within the Lombard effect in echolocating bats
  From the Cover
  
  Steffen R. Hage, Tinglei Jiang, Sean W. Berquist, Jiang Feng, and Walter Metzner
  
  PNAS March 5, 2013 110 (10) 4063-4068; https://doi.org/10.1073/pnas.1211533110
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  Reactive astrocytes secrete lcn2 to promote neuron death
  Fangfang Bi, Cao Huang, Jianbin Tong, Guang Qiu, Bo Huang, Qinxue Wu, Fang Li, Zuoshang Xu, Robert Bowser, Xu-Gang Xia, and Hongxia Zhou
  
  PNAS March 5, 2013 110 (10) 4069-4074; https://doi.org/10.1073/pnas.1218497110
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  Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelin
  Berit E. Powers, Drew L. Sellers, Emilie A. Lovelett, Willy Cheung, Sheida P. Aalami, Nikolai Zapertov, Don O. Maris, and Philip J. Horner
  
  PNAS March 5, 2013 110 (10) 4075-4080; https://doi.org/10.1073/pnas.1210293110
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  The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map
  Gina E. Elsen, Rebecca D. Hodge, Francesco Bedogni, Ray A. M. Daza, Branden R. Nelson, Naoko Shiba, Steven L. Reiner, and Robert F. Hevner
  
  PNAS March 5, 2013 110 (10) 4081-4086; https://doi.org/10.1073/pnas.1209076110
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  Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
  Bong-Kyu Choi, Mal-Gi Choi, Jae-Yeol Kim, Yoosoo Yang, Ying Lai, Dae-Hyuk Kweon, Nam Ki Lee, and Yeon-Kyun Shin
  
  PNAS March 5, 2013 110 (10) 4087-4092; https://doi.org/10.1073/pnas.1218424110
- Open Access
  Dorsolateral caudate nucleus differentiates cocaine from natural reward-associated contextual cues
  Hua-Shan Liu, Svetlana Chefer, Hanbing Lu, Karine Guillem, William Rea, Pradeep Kurup, Yihong Yang, Laura Peoples, and Elliot A. Stein
  
  PNAS March 5, 2013 110 (10) 4093-4098; https://doi.org/10.1073/pnas.1207531110
Pharmacology
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  Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure
  Kamel Maouche, Kahina Medjber, Jean-Marie Zahm, Franck Delavoie, Christine Terryn, Christelle Coraux, Stéphanie Pons, Isabelle Cloëz-Tayarani, Uwe Maskos, Philippe Birembaut, and Jean-Marie Tournier
  
  PNAS March 5, 2013 110 (10) 4099-4104; https://doi.org/10.1073/pnas.1216939110
Physiology
- Open Access
  Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics
  Marie A. Schroeder, Mohammad A. Ali, Alzbeta Hulikova, Claudiu T. Supuran, Kieran Clarke, Richard D. Vaughan-Jones, Damian J. Tyler, and Pawel Swietach
  
  PNAS March 5, 2013 110 (10) E958-E967; https://doi.org/10.1073/pnas.1213471110
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  Convergence of IRBIT, phosphatidylinositol (4,5) bisphosphate, and WNK/SPAK kinases in regulation of the Na⁺-HCO₃⁻ cotransporters family
  Jeong Hee Hong, Dongki Yang, Nikolay Shcheynikov, Ehud Ohana, Dong Min Shin, and Shmuel Muallem
  
  PNAS March 5, 2013 110 (10) 4105-4110; https://doi.org/10.1073/pnas.1221410110
Plant Biology
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  Flavodiiron proteins Flv1 and Flv3 enable cyanobacterial growth and photosynthesis under fluctuating light
  Yagut Allahverdiyeva, Henna Mustila, Maria Ermakova, Luca Bersanini, Pierre Richaud, Ghada Ajlani, Natalia Battchikova, Laurent Cournac, and Eva-Mari Aro
  
  PNAS March 5, 2013 110 (10) 4111-4116; https://doi.org/10.1073/pnas.1221194110
- Open Access
  3′ fragment of miR173-programmed RISC-cleaved RNA is protected from degradation in a complex with RISC and SGS3
  Manabu Yoshikawa, Taichiro Iki, Yasuhiro Tsutsui, Kyoko Miyashita, R. Scott Poethig, Yoshiki Habu, and Masayuki Ishikawa
  
  PNAS March 5, 2013 110 (10) 4117-4122; https://doi.org/10.1073/pnas.1217050110
Psychological and Cognitive Sciences
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  Evidence suggesting that desire-state attribution may govern food sharing in Eurasian jays
  From the Cover
  
  Ljerka Ostojić, Rachael C. Shaw, Lucy G. Cheke, and Nicola S. Clayton
  
  PNAS March 5, 2013 110 (10) 4123-4128; https://doi.org/10.1073/pnas.1209926110
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  Stress increases aversive prediction error signal in the ventral striatum
  Oliver J. Robinson, Cassie Overstreet, Danielle R. Charney, Katherine Vytal, and Christian Grillon
  
  PNAS March 5, 2013 110 (10) 4129-4133; https://doi.org/10.1073/pnas.1213923110
Sustainability Science
- Open Access
  Recent land use change in the Western Corn Belt threatens grasslands and wetlands
  Christopher K. Wright and Michael C. Wimberly
  
  PNAS March 5, 2013 110 (10) 4134-4139; https://doi.org/10.1073/pnas.1215404110
Systems Biology
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  Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program
  Xin Guo, Allister Bernard, David A. Orlando, Steven B. Haase, and Alexander J. Hartemink
  
  PNAS March 5, 2013 110 (10) E968-E977; https://doi.org/10.1073/pnas.1120991110
- Open Access
  Rate of environmental change determines stress response specificity
  Jonathan W. Young, James C. W. Locke, and Michael B. Elowitz
  
  PNAS March 5, 2013 110 (10) 4140-4145; https://doi.org/10.1073/pnas.1213060110

Corrections

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Correction for Verman and Harris, PNAS introduces new magazine section
PNAS March 5, 2013 110 (10) 4148; https://doi.org/10.1073/pnas.1302830110
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Correction for Zhang et al., TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21
PNAS March 5, 2013 110 (10) 4148; https://doi.org/10.1073/pnas.1300693110
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Correction for Morin et al., Genome sequence of the button mushroom Agaricus bisporus reveals mechanisms governing adaptation to a humic-rich ecological niche
PNAS March 5, 2013 110 (10) 4146; https://doi.org/10.1073/pnas.1300201110
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Correction for Gururaj et al., MTA1, a transcriptional activator of breast cancer amplified sequence 3
PNAS March 5, 2013 110 (10) 4147-4148; https://doi.org/10.1073/pnas.1300338110

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