Table of Contents

Biological Sciences

• Applied Biological Sciences

  • Open Access

    Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations

    Zev Williams, Iddo Z. Ben-Dov, Rony Elias, Aleksandra Mihailovic, Miguel Brown, Zev Rosenwaks, and Thomas Tuschl

    PNAS March 12, 2013 110 (11) 4255-4260; https://doi.org/10.1073/pnas.1214046110

• Biochemistry

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    Direct activation of full-length proapoptotic BAK

    Elizaveta S. Leshchiner, Craig R. Braun, Gregory H. Bird, and Loren D. Walensky

    PNAS March 12, 2013 110 (11) E986-E995; https://doi.org/10.1073/pnas.1214313110
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    Transketolase reaction under credible prebiotic conditions

    Ronald Breslow and Chandrakumar Appayee

    PNAS March 12, 2013 110 (11) 4184-4187; https://doi.org/10.1073/pnas.1301522110
  • Open Access

    Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution

    Andrea Haller, Roger B. Altman, Marie F. Soulière, Scott C. Blanchard, and Ronald Micura

    PNAS March 12, 2013 110 (11) 4188-4193; https://doi.org/10.1073/pnas.1218062110
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    Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway

    Sindy Frick, Raimund Nagel, Axel Schmidt, René R. Bodemann, Peter Rahfeld, Gerhard Pauls, Wolfgang Brandt, Jonathan Gershenzon, Wilhelm Boland, and Antje Burse

    PNAS March 12, 2013 110 (11) 4194-4199; https://doi.org/10.1073/pnas.1221489110
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    Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation

    Feng Wang, Shiladitya Sen, Yong Zhang, Insha Ahmad, Xueyong Zhu, Ian A. Wilson, Vaughn V. Smider, Thomas J. Magliery, and Peter G. Schultz

    PNAS March 12, 2013 110 (11) 4261-4266; first published February 25, 2013. https://doi.org/10.1073/pnas.1301810110
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    Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex

    • From the Cover

    Toshiharu Tsurumura, Yayoi Tsumori, Hao Qiu, Masataka Oda, Jun Sakurai, Masahiro Nagahama, and Hideaki Tsuge

    PNAS March 12, 2013 110 (11) 4267-4272; https://doi.org/10.1073/pnas.1217227110

    See companion article:

    • Model of the ADP-ribosylation reaction

      - Mar 01, 2013

• Biophysics and Computational Biology

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    Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I_Ks

    Daniel Werry, Jodene Eldstrom, Zhuren Wang, and David Fedida

    PNAS March 12, 2013 110 (11) E996-E1005; https://doi.org/10.1073/pnas.1214875110
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    Free energy landscape for the binding process of Huperzine A to acetylcholinesterase

    Fang Bai, Yechun Xu, Jing Chen, Qiufeng Liu, Junfeng Gu, Xicheng Wang, Jianpeng Ma, Honglin Li, José N. Onuchic, and Hualiang Jiang

    PNAS March 12, 2013 110 (11) 4273-4278; https://doi.org/10.1073/pnas.1301814110
  • Open Access

    Electrokinetic properties of the mammalian tectorial membrane

    Roozbeh Ghaffari, Scott L. Page, Shirin Farrahi, Jonathan B. Sellon, and Dennis M. Freeman

    PNAS March 12, 2013 110 (11) 4279-4284; https://doi.org/10.1073/pnas.1214744110
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    Membrane protein thermodynamic stability may serve as the energy sink for sorting in the periplasm

    C. Preston Moon, Nathan R. Zaccai, Patrick J. Fleming, Dennis Gessmann, and Karen G. Fleming

    PNAS March 12, 2013 110 (11) 4285-4290; https://doi.org/10.1073/pnas.1212527110
  • Open Access

    KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia

    Makarand Deo, Yanfei Ruan, Sandeep V. Pandit, Kushal Shah, Omer Berenfeld, Andrew Blaufox, Marina Cerrone, Sami F. Noujaim, Marco Denegri, José Jalife, and Silvia G. Priori

    PNAS March 12, 2013 110 (11) 4291-4296; https://doi.org/10.1073/pnas.1218154110
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    Quinone-dependent proton transfer pathways in the photosynthetic cytochrome b₆f complex

    S. Saif Hasan, Eiki Yamashita, Danas Baniulis, and William A. Cramer

    PNAS March 12, 2013 110 (11) 4297-4302; https://doi.org/10.1073/pnas.1222248110

• Cell Biology

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    Statistical method for comparing the level of intracellular organization between cells

    Zachary S. Apte and Wallace F. Marshall

    PNAS March 12, 2013 110 (11) E1006-E1015; https://doi.org/10.1073/pnas.1212277109

• Developmental Biology

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    Forces shaping a Hox morphogenetic gene network

    Sol Sotillos, Mario Aguilar, and James Castelli-Gair Hombría

    PNAS March 12, 2013 110 (11) 4303-4308; https://doi.org/10.1073/pnas.1212970110

• Ecology

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    Green-up dates in the Tibetan Plateau have continuously advanced from 1982 to 2011

    Geli Zhang, Yangjian Zhang, Jinwei Dong, and Xiangming Xiao

    PNAS March 12, 2013 110 (11) 4309-4314; https://doi.org/10.1073/pnas.1210423110

    See companion article:

    • Spring phenology advanced in Tibetan Plateau

      - May 09, 2013
    • Snow and air temperature affect spring phenology

      - Jun 05, 2013

• Environmental Sciences

  • Open Access

    Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter

    Michele Yeo, Ken Berglund, Michael Hanna, Junjie U. Guo, Jaya Kittur, Maria D. Torres, Joel Abramowitz, Jorge Busciglio, Yuan Gao, Lutz Birnbaumer, and Wolfgang B. Liedtke

    PNAS March 12, 2013 110 (11) 4315-4320; https://doi.org/10.1073/pnas.1300959110

• Genetics

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    H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A

    Paul F. South, Kayla M. Harmeyer, Nina D. Serratore, and Scott D. Briggs

    PNAS March 12, 2013 110 (11) E1016-E1025; https://doi.org/10.1073/pnas.1215768110
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    BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition

    Rizwan Haq, Satoru Yokoyama, Elena B. Hawryluk, Göran B. Jönsson, Dennie Tompers Frederick, Kevin McHenry, Dale Porter, Thanh-Nga Tran, Kevin T. Love, Robert Langer, Daniel G. Anderson, Levi A. Garraway, Lyn McDivitt Duncan, Donald L. Morton, Dave S. B. Hoon, Jennifer A. Wargo, Jun S. Song, and David E. Fisher

    PNAS March 12, 2013 110 (11) 4321-4326; https://doi.org/10.1073/pnas.1205575110

• Medical Sciences

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    Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling

    Adrian Britschgi, Anke Bill, Heike Brinkhaus, Christopher Rothwell, Ieuan Clay, Stephan Duss, Michael Rebhan, Pichai Raman, Chantale T. Guy, Kristie Wetzel, Elizabeth George, M. Oana Popa, Sarah Lilley, Hedaythul Choudhury, Martin Gosling, Louis Wang, Stephanie Fitzgerald, Jason Borawski, Jonathan Baffoe, Mark Labow, L. Alex Gaither, and Mohamed Bentires-Alj

    PNAS March 12, 2013 110 (11) E1026-E1034; https://doi.org/10.1073/pnas.1217072110
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    Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning

    Isabell Hess, Norimasa Iwanami, Michael Schorpp, and Thomas Boehm

    PNAS March 12, 2013 110 (11) 4327-4332; https://doi.org/10.1073/pnas.1219847110
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    Hypothalamic ventromedial COUP-TFII protects against hypoglycemia-associated autonomic failure

    Lina Sabra-Makke, Micol Maritan, Julien Planchais, Marie Boutant, Jean-Paul Pégorier, Patrick C. Even, Mireille Vasseur-Cognet, and Pascale Bossard

    PNAS March 12, 2013 110 (11) 4333-4338; https://doi.org/10.1073/pnas.1219262110
  • Open Access

    PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies

    Akio Iwanami, Beatrice Gini, Ciro Zanca, Tomoo Matsutani, Alvaro Assuncao, Ali Nael, Julie Dang, Huijun Yang, Shaojun Zhu, Jun Kohyama, Issay Kitabayashi, Webster K. Cavenee, Timothy F. Cloughesy, Frank B. Furnari, Masaya Nakamura, Yoshiaki Toyama, Hideyuki Okano, and Paul S. Mischel

    PNAS March 12, 2013 110 (11) 4339-4344; https://doi.org/10.1073/pnas.1217602110

• Microbiology

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    Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence

    Nicolas Mirouze, Mathieu A. Bergé, Anne-Lise Soulet, Isabelle Mortier-Barrière, Yves Quentin, Gwennaele Fichant, Chantal Granadel, Marie-Françoise Noirot-Gros, Philippe Noirot, Patrice Polard, Bernard Martin, and Jean-Pierre Claverys

    PNAS March 12, 2013 110 (11) E1035-E1044; https://doi.org/10.1073/pnas.1219868110
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    Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza

    • Inaugural Article

    Michael B. A. Oldstone

    PNAS March 12, 2013 110 (11) 4180-4183; https://doi.org/10.1073/pnas.1222025110

    See companion article:

    • Profile of Michael B. A. Oldstone

      - Mar 04, 2013
  • Open Access

    Biofilm streamers cause catastrophic disruption of flow with consequences for environmental and medical systems

    Knut Drescher, Yi Shen, Bonnie L. Bassler, and Howard A. Stone

    PNAS March 12, 2013 110 (11) 4345-4350; https://doi.org/10.1073/pnas.1300321110
  • Open Access

    Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9

    Jean-Philippe Julien, Jeong Hyun Lee, Albert Cupo, Charles D. Murin, Ronald Derking, Simon Hoffenberg, Michael J. Caulfield, C. Richter King, Andre J. Marozsan, Per Johan Klasse, Rogier W. Sanders, John P. Moore, Ian A. Wilson, and Andrew B. Ward

    PNAS March 12, 2013 110 (11) 4351-4356; https://doi.org/10.1073/pnas.1217537110

• Neuroscience

  • Open Access

    Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice

    Giovanna Ponti, Kirsten Obernier, Cristina Guinto, Lingu Jose, Luca Bonfanti, and Arturo Alvarez-Buylla

    PNAS March 12, 2013 110 (11) E1045-E1054; https://doi.org/10.1073/pnas.1219563110
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    Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex

    Magali Richard, Thomas Boulin, Valérie J. P. Robert, Janet E. Richmond, and Jean-Louis Bessereau

    PNAS March 12, 2013 110 (11) E1055-E1063; https://doi.org/10.1073/pnas.1216154110
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    Reversal of age-related neural timing delays with training

    Samira Anderson, Travis White-Schwoch, Alexandra Parbery-Clark, and Nina Kraus

    PNAS March 12, 2013 110 (11) 4357-4362; https://doi.org/10.1073/pnas.1213555110
  • Open Access

    Superiority illusion arises from resting-state brain networks modulated by dopamine

    Makiko Yamada, Lucina Q. Uddin, Hidehiko Takahashi, Yasuyuki Kimura, Keisuke Takahata, Ririko Kousa, Yoko Ikoma, Yoko Eguchi, Harumasa Takano, Hiroshi Ito, Makoto Higuchi, and Tetsuya Suhara

    PNAS March 12, 2013 110 (11) 4363-4367; https://doi.org/10.1073/pnas.1221681110
  • Open Access

    Sensory adaptation as optimal resource allocation

    Sergei Gepshtein, Luis A. Lesmes, and Thomas D. Albright

    PNAS March 12, 2013 110 (11) 4368-4373; https://doi.org/10.1073/pnas.1204109110
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    Lifespan of neurons is uncoupled from organismal lifespan

    Lorenzo Magrassi, Ketty Leto, and Ferdinando Rossi

    PNAS March 12, 2013 110 (11) 4374-4379; https://doi.org/10.1073/pnas.1217505110
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    Resolving the transition from negative to positive blood oxygen level-dependent responses in the developing brain

    Mariel G. Kozberg, Brenda R. Chen, Sarah E. DeLeo, Matthew B. Bouchard, and Elizabeth M. C. Hillman

    PNAS March 12, 2013 110 (11) 4380-4385; https://doi.org/10.1073/pnas.1212785110
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    Genotype–phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of K_v7.2 potassium channel subunits

    Francesco Miceli, Maria Virginia Soldovieri, Paolo Ambrosino, Vincenzo Barrese, Michele Migliore, Maria Roberta Cilio, and Maurizio Taglialatela

    PNAS March 12, 2013 110 (11) 4386-4391; https://doi.org/10.1073/pnas.1216867110
  • Open Access

    Time-varying functional network information extracted from brief instances of spontaneous brain activity

    Xiao Liu and Jeff H. Duyn

    PNAS March 12, 2013 110 (11) 4392-4397; https://doi.org/10.1073/pnas.1216856110
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    Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples

    Maria Pangalos, José R. Donoso, Jochen Winterer, Aleksandar R. Zivkovic, Richard Kempter, Nikolaus Maier, and Dietmar Schmitz

    PNAS March 12, 2013 110 (11) 4398-4403; https://doi.org/10.1073/pnas.1215496110

• Pharmacology

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    Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle

    Kang-Yang Jih and Tzyh-Chang Hwang

    PNAS March 12, 2013 110 (11) 4404-4409; https://doi.org/10.1073/pnas.1215982110

• Physiology

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    Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

    Jennifer L. Pluznick, Ryan J. Protzko, Haykanush Gevorgyan, Zita Peterlin, Arnold Sipos, Jinah Han, Isabelle Brunet, La-Xiang Wan, Federico Rey, Tong Wang, Stuart J. Firestein, Masashi Yanagisawa, Jeffrey I. Gordon, Anne Eichmann, Janos Peti-Peterdi, and Michael J. Caplan

    PNAS March 12, 2013 110 (11) 4410-4415; https://doi.org/10.1073/pnas.1215927110
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    Autonomous regulation of the insect gut by circadian genes acting downstream of juvenile hormone signaling

    Adam Bajgar, Marek Jindra, and David Dolezel

    PNAS March 12, 2013 110 (11) 4416-4421; https://doi.org/10.1073/pnas.1217060110

• Psychological and Cognitive Sciences

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    The brain uses adaptive internal models of scene statistics for sensorimotor estimation and planning

    Oh-Sang Kwon and David C. Knill

    PNAS March 12, 2013 110 (11) E1064-E1073; https://doi.org/10.1073/pnas.1214869110
  • Open Access

    Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving

    • From the Cover

    Takuya Hayashi, Ji Hyun Ko, Antonio P. Strafella, and Alain Dagher

    PNAS March 12, 2013 110 (11) 4422-4427; https://doi.org/10.1073/pnas.1212185110

    See companion article:

    • Control of craving by the prefrontal cortex

      - Mar 04, 2013

• Systems Biology

  • Open Access

    Pattern discovery and cancer gene identification in integrated cancer genomic data

    Qianxing Mo, Sijian Wang, Venkatraman E. Seshan, Adam B. Olshen, Nikolaus Schultz, Chris Sander, R. Scott Powers, Marc Ladanyi, and Ronglai Shen

    PNAS March 12, 2013 110 (11) 4245-4250; https://doi.org/10.1073/pnas.1208949110