MEDICAL SCIENCES Correction for “Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59,” by Ali H. Ellebedy, Christopher Lupfer, Hazem E. Ghoneim, Jennifer DeBeauchamp, Thirumala-Devi Kanneganti, and Richard J. Webby, which appeared in issue 7, February 15, 2011, of Proc Natl Acad Sci USA (108:2927–2932; first published January 26, 2011; 10.1073/pnas.1012455108).

The authors wish to note the following: “In Ellebedy et al. we showed a role for the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. However, in pilot studies in an alternative ASC-deficient mouse line generated by Dr. V. Dixit (Genentech, Inc.), this phenotype was not reproduced. A similar observation was recently reported, thus highlighting differences in the available ASC-deficient mouse lines (1). The data in Ellebedy et al. is accurate, and in that line of ASC-deficient mice there is indeed a reduced adjuvant effect of MF59. We stand by that data, but caution should be used in interpreting data gained from the different ASC-deficient mice.”