Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Assembly of complex cell microenvironments using geometrically docked hydrogel shapes

    George Eng, Benjamin W. Lee, Hesam Parsa, Curtis D. Chin, Jesse Schneider, Gary Linkov, Samuel K. Sia, and Gordana Vunjak-Novakovic

    PNAS March 19, 2013 110 (12) 4551-4556; https://doi.org/10.1073/pnas.1300569110
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    Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs

    Hitomi Matsunari, Hiroshi Nagashima, Masahito Watanabe, Kazuhiro Umeyama, Kazuaki Nakano, Masaki Nagaya, Toshihiro Kobayashi, Tomoyuki Yamaguchi, Ryo Sumazaki, Leonard A. Herzenberg, and Hiromitsu Nakauchi

    PNAS March 19, 2013 110 (12) 4557-4562; https://doi.org/10.1073/pnas.1222902110
  • Open Access

    Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

    Mikaël M. Martino, Priscilla S. Briquez, Adrian Ranga, Matthias P. Lutolf, and Jeffrey A. Hubbell

    PNAS March 19, 2013 110 (12) 4563-4568; https://doi.org/10.1073/pnas.1221602110

• Biochemistry

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    Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma

    Mingqian Feng, Wei Gao, Ruoqi Wang, Weizao Chen, Yan-Gao Man, William Douglas Figg, Xin Wei Wang, Dimiter S. Dimitrov, and Mitchell Ho

    PNAS March 19, 2013 110 (12) E1083-E1091; https://doi.org/10.1073/pnas.1217868110
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    Diradical intermediate within the context of tryptophan tryptophylquinone biosynthesis

    Erik T. Yukl, Fange Liu, J. Krzystek, Sooim Shin, Lyndal M. R. Jensen, Victor L. Davidson, Carrie M. Wilmot, and Aimin Liu

    PNAS March 19, 2013 110 (12) 4569-4573; https://doi.org/10.1073/pnas.1215011110
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    NMR-based functional profiling of RASopathies and oncogenic RAS mutations

    Matthew J. Smith, Benjamin G. Neel, and Mitsuhiko Ikura

    PNAS March 19, 2013 110 (12) 4574-4579; https://doi.org/10.1073/pnas.1218173110
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    Structure of the trypanosome cyanide-insensitive alternative oxidase

    Tomoo Shiba, Yasutoshi Kido, Kimitoshi Sakamoto, Daniel Ken Inaoka, Chiaki Tsuge, Ryoko Tatsumi, Gen Takahashi, Emmanuel Oluwadare Balogun, Takeshi Nara, Takashi Aoki, Teruki Honma, Akiko Tanaka, Masayuki Inoue, Shigeru Matsuoka, Hiroyuki Saimoto, Anthony L. Moore, Shigeharu Harada, and Kiyoshi Kita

    PNAS March 19, 2013 110 (12) 4580-4585; https://doi.org/10.1073/pnas.1218386110

• Biophysics and Computational Biology

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    Structural model for the protein-translocating element of the twin-arginine transport system

    Fernanda Rodriguez, Sarah L. Rouse, Claudia E. Tait, Jeffrey Harmer, Antonio De Riso, Christiane R. Timmel, Mark S. P. Sansom, Ben C. Berks, and Jason R. Schnell

    PNAS March 19, 2013 110 (12) E1092-E1101; https://doi.org/10.1073/pnas.1219486110
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    Emergence of metachronal waves in cilia arrays

    Jens Elgeti and Gerhard Gompper

    PNAS March 19, 2013 110 (12) 4470-4475; https://doi.org/10.1073/pnas.1218869110
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    Monolayer curvature stabilizes nanoscale raft domains in mixed lipid bilayers

    Sebastian Meinhardt, Richard L. C. Vink, and Friederike Schmid

    PNAS March 19, 2013 110 (12) 4476-4481; https://doi.org/10.1073/pnas.1221075110
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    From mechanical folding trajectories to intrinsic energy landscapes of biopolymers

    Michael Hinczewski, J. Christof M. Gebhardt, Matthias Rief, and D. Thirumalai

    PNAS March 19, 2013 110 (12) 4500-4505; https://doi.org/10.1073/pnas.1214051110
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    Viscoelastic properties of the nematode Caenorhabditis elegans, a self-similar, shear-thinning worm

    Matilda Backholm, William S. Ryu, and Kari Dalnoki-Veress

    PNAS March 19, 2013 110 (12) 4528-4533; https://doi.org/10.1073/pnas.1219965110
  • Open Access

    Crystal structure and functional mechanism of a human antimicrobial membrane channel

    Chen Song, Conrad Weichbrodt, Evgeniy S. Salnikov, Marek Dynowski, Björn O. Forsberg, Burkhard Bechinger, Claudia Steinem, Bert L. de Groot, Ulrich Zachariae, and Kornelius Zeth

    PNAS March 19, 2013 110 (12) 4586-4591; https://doi.org/10.1073/pnas.1214739110
  • Open Access

    Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies

    Audray K. Harris, Joel R. Meyerson, Yumiko Matsuoka, Oleg Kuybeda, Amy Moran, Donald Bliss, Suman R. Das, Jonathan W. Yewdell, Guillermo Sapiro, Kanta Subbarao, and Sriram Subramaniam

    PNAS March 19, 2013 110 (12) 4592-4597; https://doi.org/10.1073/pnas.1214913110

• Cell Biology

  • Open Access

    Nitration of Hsp90 induces cell death

    Maria Clara Franco, Yaozu Ye, Christian A. Refakis, Jessica L. Feldman, Audrey L. Stokes, Manuela Basso, Raquel M. Melero Fernández de Mera, Nicklaus A. Sparrow, Noel Y. Calingasan, Mahmoud Kiaei, Timothy W. Rhoads, Thong C. Ma, Martin Grumet, Stephen Barnes, M. Flint Beal, Joseph S. Beckman, Ryan Mehl, and Alvaro G. Estévez

    PNAS March 19, 2013 110 (12) E1102-E1111; https://doi.org/10.1073/pnas.1215177110
  • Open Access

    Rare somatic cells from human breast tissue exhibit extensive lineage plasticity

    Somdutta Roy, Philippe Gascard, Nancy Dumont, Jianxin Zhao, Deng Pan, Sarah Petrie, Marta Margeta, and Thea D. Tlsty

    PNAS March 19, 2013 110 (12) 4598-4603; https://doi.org/10.1073/pnas.1218682110
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    HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila

    Ying Xiong, Kai Zhao, Jiaxi Wu, Zhiheng Xu, Shan Jin, and Yong Q. Zhang

    PNAS March 19, 2013 110 (12) 4604-4609; https://doi.org/10.1073/pnas.1207586110
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    Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation

    Na-Ryum Bin, Chang Hun Jung, Christopher Piggott, and Shuzo Sugita

    PNAS March 19, 2013 110 (12) 4610-4615; https://doi.org/10.1073/pnas.1214887110
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    ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways

    Ray-Chang Wu, Ming Jiang, Arthur L. Beaudet, and Mei-Yi Wu

    PNAS March 19, 2013 110 (12) 4616-4621; https://doi.org/10.1073/pnas.1218318110
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    PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

    Kasper M. Rouschop, Ludwig J. Dubois, Tom G. Keulers, Twan van den Beucken, Philippe Lambin, Johan Bussink, Albert J. van der Kogel, Marianne Koritzinsky, and Bradly G. Wouters

    PNAS March 19, 2013 110 (12) 4622-4627; https://doi.org/10.1073/pnas.1210633110
  • Open Access

    Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

    Romain Volmer, Kattria van der Ploeg, and David Ron

    PNAS March 19, 2013 110 (12) 4628-4633; https://doi.org/10.1073/pnas.1217611110

• Developmental Biology

  • Open Access

    Arf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells

    Chunliang Li, David Finkelstein, and Charles J. Sherr

    PNAS March 19, 2013 110 (12) E1112-E1121; https://doi.org/10.1073/pnas.1302184110
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    Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo

    Jayhun Lee, Charlene S. L. Hoi, Karin C. Lilja, Brian S. White, Song Eun Lee, David Shalloway, and Tudorita Tumbar

    PNAS March 19, 2013 110 (12) 4634-4639; https://doi.org/10.1073/pnas.1213015110
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    Role for compartmentalization in nephron progenitor differentiation

    Aaron C. Brown, Sree Deepthi Muthukrishnan, Justin A. Guay, Derek C. Adams, Dillon A. Schafer, Jennifer L. Fetting, and Leif Oxburgh

    PNAS March 19, 2013 110 (12) 4640-4645; https://doi.org/10.1073/pnas.1213971110

• Ecology

  • Open Access

    Scaling body size fluctuations

    Andrea Giometto, Florian Altermatt, Francesco Carrara, Amos Maritan, and Andrea Rinaldo

    PNAS March 19, 2013 110 (12) 4646-4650; https://doi.org/10.1073/pnas.1301552110
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    Evidence for a persistent microbial seed bank throughout the global ocean

    Sean M. Gibbons, J. Gregory Caporaso, Meg Pirrung, Dawn Field, Rob Knight, and Jack A. Gilbert

    PNAS March 19, 2013 110 (12) 4651-4655; https://doi.org/10.1073/pnas.1217767110
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    Historical changes in northeastern US bee pollinators related to shared ecological traits

    • From the Cover

    Ignasi Bartomeus, John S. Ascher, Jason Gibbs, Bryan N. Danforth, David L. Wagner, Shannon M. Hedtke, and Rachael Winfree

    PNAS March 19, 2013 110 (12) 4656-4660; https://doi.org/10.1073/pnas.1218503110
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    Compensatory escape mechanism at low Reynolds number

    Brad J. Gemmell, Jian Sheng, and Edward J. Buskey

    PNAS March 19, 2013 110 (12) 4661-4666; https://doi.org/10.1073/pnas.1212148110

• Environmental Sciences

  • Open Access

    Uranium redox transition pathways in acetate-amended sediments

    John R. Bargar, Kenneth H. Williams, Kate M. Campbell, Philip E. Long, Joanne E. Stubbs, ElenaI I. Suvorova, Juan S. Lezama-Pacheco, Daniel S. Alessi, Malgorzata Stylo, Samuel M. Webb, James A. Davis, Daniel E. Giammar, Lisa Y. Blue, and Rizlan Bernier-Latmani

    PNAS March 19, 2013 110 (12) 4506-4511; https://doi.org/10.1073/pnas.1219198110

• Genetics

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    Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

    Bertrand Coste, Gunnar Houge, Michael F. Murray, Nathan Stitziel, Michael Bandell, Monica A. Giovanni, Anthony Philippakis, Alexander Hoischen, Gunnar Riemer, Unni Steen, Vidar Martin Steen, Jayanti Mathur, James Cox, Matthew Lebo, Heidi Rehm, Scott T. Weiss, John N. Wood, Richard L. Maas, Shamil R. Sunyaev, and Ardem Patapoutian

    PNAS March 19, 2013 110 (12) 4667-4672; https://doi.org/10.1073/pnas.1221400110
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    Identification of genetic variants influencing the human plasma proteome

    Åsa Johansson, Stefan Enroth, Magnus Palmblad, André M. Deelder, Jonas Bergquist, and Ulf Gyllensten

    PNAS March 19, 2013 110 (12) 4673-4678; https://doi.org/10.1073/pnas.1217238110

• Immunology

  • Open Access

    Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells

    Amy S. McKee, Matthew A. Burchill, Michael W. Munks, Lei Jin, John W. Kappler, Rachel S. Friedman, Jordan Jacobelli, and Philippa Marrack

    PNAS March 19, 2013 110 (12) E1122-E1131; https://doi.org/10.1073/pnas.1300392110
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    Murine thymic selection quantified using a unique method to capture deleted T cells

    Gretta L. Stritesky, Yan Xing, Jami R. Erickson, Lokesh A. Kalekar, Xiaodan Wang, Daniel L. Mueller, Stephen C. Jameson, and Kristin A. Hogquist

    PNAS March 19, 2013 110 (12) 4679-4684; https://doi.org/10.1073/pnas.1217532110
  • Open Access

    Dimerization of complement factor H-related proteins modulates complement activation in vivo

    Elena Goicoechea de Jorge, Joseph J. E. Caesar, Talat H. Malik, Mitali Patel, Matthew Colledge, Steven Johnson, Svetlana Hakobyan, B. Paul Morgan, Claire L. Harris, Matthew C. Pickering, and Susan M. Lea

    PNAS March 19, 2013 110 (12) 4685-4690; https://doi.org/10.1073/pnas.1219260110
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    Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

    Hiroyuki Hosokawa, Tomoaki Tanaka, Yutaka Suzuki, Chiaki Iwamura, Shuichi Ohkubo, Kanji Endoh, Miki Kato, Yusuke Endo, Atsushi Onodera, Damon John Tumes, Akinori Kanai, Sumio Sugano, and Toshinori Nakayama

    PNAS March 19, 2013 110 (12) 4691-4696; https://doi.org/10.1073/pnas.1220865110

• Medical Sciences

  • Open Access

    Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome

    • From the Cover

    Carla S. Möller-Levet, Simon N. Archer, Giselda Bucca, Emma E. Laing, Ana Slak, Renata Kabiljo, June C. Y. Lo, Nayantara Santhi, Malcolm von Schantz, Colin P. Smith, and Derk-Jan Dijk

    PNAS March 19, 2013 110 (12) E1132-E1141; https://doi.org/10.1073/pnas.1217154110
  • Open Access

    Electroencephalogram signatures of loss and recovery of consciousness from propofol

    Patrick L. Purdon, Eric T. Pierce, Eran A. Mukamel, Michael J. Prerau, John L. Walsh, Kin Foon K. Wong, Andres F. Salazar-Gomez, Priscilla G. Harrell, Aaron L. Sampson, Aylin Cimenser, ShiNung Ching, Nancy J. Kopell, Casie Tavares-Stoeckel, Kathleen Habeeb, Rebecca Merhar, and Emery N. Brown

    PNAS March 19, 2013 110 (12) E1142-E1151; https://doi.org/10.1073/pnas.1221180110
  • Open Access

    Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

    • From the Cover

    Andrea Serio, Bilada Bilican, Sami J. Barmada, Dale Michael Ando, Chen Zhao, Rick Siller, Karen Burr, Ghazal Haghi, David Story, Agnes Lumi Nishimura, Monica A. Carrasco, Hemali P. Phatnani, Carole Shum, Ian Wilmut, Tom Maniatis, Christopher E. Shaw, Steven Finkbeiner, and Siddharthan Chandran

    PNAS March 19, 2013 110 (12) 4697-4702; https://doi.org/10.1073/pnas.1300398110

    See companion article:

    • Primary astrocyte disease in TDP-43 proteinopathy

      - Mar 19, 2013
  • Open Access

    Quantification of excess risk for diabetes for those born in times of hunger, in an entire population of a nation, across a century

    Stefan Thurner, Peter Klimek, Michael Szell, Georg Duftschmid, Gottfried Endel, Alexandra Kautzky-Willer, and David C. Kasper

    PNAS March 19, 2013 110 (12) 4703-4707; https://doi.org/10.1073/pnas.1215626110

    See companion article:

    • Can viral infections explain diabetes data?

      - Jul 23, 2013
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    Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription

    Paul Mak, Cheng Chang, Bryan Pursell, and Arthur M. Mercurio

    PNAS March 19, 2013 110 (12) 4708-4713; https://doi.org/10.1073/pnas.1221654110
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    TLR4–MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide

    Yuji Kondo, Kazutaka Ikeda, Noriyo Tokuda, Chiaki Nishitani, Umeharu Ohto, Sachiko Akashi-Takamura, Yasutomo Ito, Makoto Uchikawa, Yoshio Kuroki, Ryo Taguchi, Kensuke Miyake, Qing Zhang, Keiko Furukawa, and Koichi Furukawa

    PNAS March 19, 2013 110 (12) 4714-4719; https://doi.org/10.1073/pnas.1218508110

• Microbiology

  • Open Access

    Shigella impairs T lymphocyte dynamics in vivo

    • Inaugural Article

    Wilmara Salgado-Pabón, Susanna Celli, Ellen T. Arena, Katharina Nothelfer, Pascal Roux, Gernot Sellge, Elisabetta Frigimelica, Philippe Bousso, Philippe J. Sansonetti, and Armelle Phalipon

    PNAS March 19, 2013 110 (12) 4458-4463; https://doi.org/10.1073/pnas.1300981110

    See companion article:

    • QnAs with Philippe J. Sansonetti

      - Mar 19, 2013
  • Open Access

    Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing

    David Berry, Bärbel Stecher, Arno Schintlmeister, Jochen Reichert, Sandrine Brugiroux, Birgit Wild, Wolfgang Wanek, Andreas Richter, Isabella Rauch, Thomas Decker, Alexander Loy, and Michael Wagner

    PNAS March 19, 2013 110 (12) 4720-4725; https://doi.org/10.1073/pnas.1219247110
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    Genome-scale analysis of gene function in the hydrogenotrophic methanogenic archaeon Methanococcus maripaludis

    Felipe Sarmiento, Jan Mrázek, and William B. Whitman

    PNAS March 19, 2013 110 (12) 4726-4731; https://doi.org/10.1073/pnas.1220225110

• Neuroscience

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    Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb

    Aditi Deshpande, Matteo Bergami, Alexander Ghanem, Karl-Klaus Conzelmann, Alexandra Lepier, Magdalena Götz, and Benedikt Berninger

    PNAS March 19, 2013 110 (12) E1152-E1161; https://doi.org/10.1073/pnas.1218991110
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    Contrasting effects on path integration after hippocampal damage in humans and rats

    Soyun Kim, Maya Sapiurka, Robert E. Clark, and Larry R. Squire

    PNAS March 19, 2013 110 (12) 4732-4737; https://doi.org/10.1073/pnas.1300869110
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    Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism

    Koichi Takeuchi, Michael J. Gertner, Jing Zhou, Luis F. Parada, Michael V. L. Bennett, and R. Suzanne Zukin

    PNAS March 19, 2013 110 (12) 4738-4743; https://doi.org/10.1073/pnas.1222803110
  • Open Access

    Altered paralimbic interaction in behavioral addiction

    Kristine Rømer Thomsen, Morten Joensson, Hans C. Lou, Arne Møller, Joachim Gross, Morten L. Kringelbach, and Jean-Pierre Changeux

    PNAS March 19, 2013 110 (12) 4744-4749; https://doi.org/10.1073/pnas.1302374110
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    Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock

    Guangsen Shi, Lijuan Xing, Zhiwei Liu, Zhipeng Qu, Xi Wu, Zhen Dong, Xiaohan Wang, Xiang Gao, Moli Huang, Jie Yan, Ling Yang, Yi Liu, Louis J. Ptáček, and Ying Xu

    PNAS March 19, 2013 110 (12) 4750-4755; https://doi.org/10.1073/pnas.1302560110
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    Task-related “cortical” bursting depends critically on basal ganglia input and is linked to vocal plasticity

    • Cozzarelli Prize Winner

    Satoshi Kojima, Mimi H. Kao, and Allison J. Doupe

    PNAS March 19, 2013 110 (12) 4756-4761; https://doi.org/10.1073/pnas.1216308110
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    Mouse alarm pheromone shares structural similarity with predator scents

    Julien Brechbühl, Fabian Moine, Magali Klaey, Monique Nenniger-Tosato, Nicolas Hurni, Frank Sporkert, Christian Giroud, and Marie-Christine Broillet

    PNAS March 19, 2013 110 (12) 4762-4767; https://doi.org/10.1073/pnas.1214249110
  • Open Access

    Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity

    Neda Jahanshad, Priya Rajagopalan, Xue Hua, Derrek P. Hibar, Talia M. Nir, Arthur W. Toga, Clifford R. Jack Jr, Andrew J. Saykin, Robert C. Green, Michael W. Weiner, Sarah E. Medland, Grant W. Montgomery, Narelle K. Hansell, Katie L. McMahon, Greig I. de Zubicaray, Nicholas G. Martin, Margaret J. Wright, Paul M. Thompson, and the Alzheimer’s Disease Neuroimaging Initiative

    PNAS March 19, 2013 110 (12) 4768-4773; https://doi.org/10.1073/pnas.1216206110
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    Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation

    Florence Cotel, Richard Exley, Stephanie J. Cragg, and Jean-François Perrier

    PNAS March 19, 2013 110 (12) 4774-4779; https://doi.org/10.1073/pnas.1216150110
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    Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease

    Coralie de Hemptinne, Elena S. Ryapolova-Webb, Ellen L. Air, Paul A. Garcia, Kai J. Miller, Jeffrey G. Ojemann, Jill L. Ostrem, Nicholas B. Galifianakis, and Philip A. Starr

    PNAS March 19, 2013 110 (12) 4780-4785; https://doi.org/10.1073/pnas.1214546110
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    Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade

    Luigi Bellocchio, Edgar Soria-Gómez, Carmelo Quarta, Mathilde Metna-Laurent, Pierre Cardinal, Elke Binder, Astrid Cannich, Anna Delamarre, Martin Häring, Mar Martín-Fontecha, David Vega, Thierry Leste-Lasserre, Dusan Bartsch, Krisztina Monory, Beat Lutz, Francis Chaouloff, Uberto Pagotto, Manuel Guzman, Daniela Cota, and Giovanni Marsicano

    PNAS March 19, 2013 110 (12) 4786-4791; https://doi.org/10.1073/pnas.1218573110
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    Pubertally born neurons and glia are functionally integrated into limbic and hypothalamic circuits of the male Syrian hamster

    Margaret A. Mohr and Cheryl L. Sisk

    PNAS March 19, 2013 110 (12) 4792-4797; https://doi.org/10.1073/pnas.1219443110
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    Learning and reconsolidation implicate different synaptic mechanisms

    Yan Li, Edward G. Meloni, William A. Carlezon Jr., Mohammed R. Milad, Roger K. Pitman, Karim Nader, and Vadim Y. Bolshakov

    PNAS March 19, 2013 110 (12) 4798-4803; https://doi.org/10.1073/pnas.1217878110

• Pharmacology

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    L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors

    Carla Nasca, Dionysios Xenos, Ylenia Barone, Alessandra Caruso, Sergio Scaccianoce, Francesco Matrisciano, Giuseppe Battaglia, Aleksander A. Mathé, Anna Pittaluga, Luana Lionetto, Maurizio Simmaco, and Ferdinando Nicoletti

    PNAS March 19, 2013 110 (12) 4804-4809; https://doi.org/10.1073/pnas.1216100110

    See companion article:

    • Rapid epigenetic regulators

      - Mar 19, 2013

• Physiology

  • Open Access

    Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

    Chilman Bae, Radhakrishnan Gnanasambandam, Chris Nicolai, Frederick Sachs, and Philip A. Gottlieb

    PNAS March 19, 2013 110 (12) E1162-E1168; https://doi.org/10.1073/pnas.1219777110
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    Role of caspase-1 in regulation of triglyceride metabolism

    Maya E. Kotas, Michael J. Jurczak, Charles Annicelli, Matthew P. Gillum, Gary W. Cline, Gerald I. Shulman, and Ruslan Medzhitov

    PNAS March 19, 2013 110 (12) 4810-4815; https://doi.org/10.1073/pnas.1301996110
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    Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels

    Toshinori Hoshi, Bianka Wissuwa, Yutao Tian, Nobuyoshi Tajima, Rong Xu, Michael Bauer, Stefan H. Heinemann, and Shangwei Hou

    PNAS March 19, 2013 110 (12) 4816-4821; https://doi.org/10.1073/pnas.1221997110

    See companion article:

    • DHA and BK channels

      - Mar 19, 2013

    See companion article:

    • Omega-3 fatty and their derivatives

      - Jun 18, 2013
  • You have access

    Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA

    Toshinori Hoshi, Yutao Tian, Rong Xu, Stefan H. Heinemann, and Shangwei Hou

    PNAS March 19, 2013 110 (12) 4822-4827; https://doi.org/10.1073/pnas.1222003110

    See companion article:

    • Omega-3 fatty acids and BK channels

      - Mar 19, 2013
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    Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca²⁺-sensing and SK channel activation

    Miao Zhang, John M. Pascal, and Ji-Fang Zhang

    PNAS March 19, 2013 110 (12) 4828-4833; https://doi.org/10.1073/pnas.1220253110

• Plant Biology

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    An RNA recognition motif-containing protein is required for plastid RNA editing in Arabidopsis and maize

    Tao Sun, Arnaud Germain, Ludovic Giloteaux, Kamel Hammani, Alice Barkan, Maureen R. Hanson, and Stéphane Bentolila

    PNAS March 19, 2013 110 (12) E1169-E1178; https://doi.org/10.1073/pnas.1220162110
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    Gibberellins accumulate in the elongating endodermal cells of Arabidopsis root

    • From the Cover

    Eilon Shani, Roy Weinstain, Yi Zhang, Cristina Castillejo, Eirini Kaiserli, Joanne Chory, Roger Y. Tsien, and Mark Estelle

    PNAS March 19, 2013 110 (12) 4834-4839; https://doi.org/10.1073/pnas.1300436110

    See companion article:

    • Gibberellin site of action

      - Mar 19, 2013
  • Open Access

    Arabidopsis AHP2, AHP3, and AHP5 histidine phosphotransfer proteins function as redundant negative regulators of drought stress response

    Rie Nishiyama, Yasuko Watanabe, Marco A. Leyva-Gonzalez, Chien Van Ha, Yasunari Fujita, Maho Tanaka, Motoaki Seki, Kazuko Yamaguchi-Shinozaki, Kazuo Shinozaki, Luis Herrera-Estrella, and Lam-Son Phan Tran

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