Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions

    Guangchuan Wang, Rui-Yuan Cao, Rong Chen, Lijuan Mo, Jian-Feng Han, Xiaoyu Wang, Xurong Xu, Tao Jiang, Yong-Qiang Deng, Ke Lyu, Shun-Ya Zhu, E-De Qin, Ruikang Tang, and Cheng-Feng Qin

    PNAS May 7, 2013 110 (19) 7619-7624; https://doi.org/10.1073/pnas.1300233110
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    Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates

    Chung Hang J. Choi, Liangliang Hao, Suguna P. Narayan, Evelyn Auyeung, and Chad A. Mirkin

    PNAS May 7, 2013 110 (19) 7625-7630; https://doi.org/10.1073/pnas.1305804110
  • Open Access

    A thin polymer membrane, nano-suit, enhancing survival across the continuum between air and high vacuum

    • From the Cover

    Yasuharu Takaku, Hiroshi Suzuki, Isao Ohta, Daisuke Ishii, Yoshinori Muranaka, Masatsugu Shimomura, and Takahiko Hariyama

    PNAS May 7, 2013 110 (19) 7631-7635; https://doi.org/10.1073/pnas.1221341110
  • Open Access

    Synthesis of customized petroleum-replica fuel molecules by targeted modification of free fatty acid pools in Escherichia coli

    Thomas P. Howard, Sabine Middelhaufe, Karen Moore, Christoph Edner, Dagmara M. Kolak, George N. Taylor, David A. Parker, Rob Lee, Nicholas Smirnoff, Stephen J. Aves, and John Love

    PNAS May 7, 2013 110 (19) 7636-7641; https://doi.org/10.1073/pnas.1215966110
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    Transporter-mediated biofuel secretion

    Rupak Doshi, Tuan Nguyen, and Geoffrey Chang

    PNAS May 7, 2013 110 (19) 7642-7647; https://doi.org/10.1073/pnas.1301358110

• Biochemistry

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    Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets

    Youngchang Kim, Zi Ye, Grazyna Joachimiak, Patrick Videau, Jasmine Young, Kathryn Hurd, Sean M. Callahan, Piotr Gornicki, Jindong Zhao, Robert Haselkorn, and Andrzej Joachimiak

    PNAS May 7, 2013 110 (19) E1716-E1723; https://doi.org/10.1073/pnas.1305971110
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    Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis

    Richard W. Gantt, Pauline Peltier-Pain, Shanteri Singh, Maoquan Zhou, and Jon S. Thorson

    PNAS May 7, 2013 110 (19) 7648-7653; https://doi.org/10.1073/pnas.1220220110
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    Histone chaperone FACT action during transcription through chromatin by RNA polymerase II

    Fu-Kai Hsieh, Olga I. Kulaeva, Smita S. Patel, Pamela N. Dyer, Karolin Luger, Danny Reinberg, and Vasily M. Studitsky

    PNAS May 7, 2013 110 (19) 7654-7659; https://doi.org/10.1073/pnas.1222198110
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    Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains

    Matthew B. Lohse, Aaron D. Hernday, Polly M. Fordyce, Liron Noiman, Trevor R. Sorrells, Victor Hanson-Smith, Clarissa J. Nobile, Joseph L. DeRisi, and Alexander D. Johnson

    PNAS May 7, 2013 110 (19) 7660-7665; https://doi.org/10.1073/pnas.1221734110
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    Precise timing of ATPase activation drives targeting of tail-anchored proteins

    Michael E. Rome, Meera Rao, William M. Clemons, and Shu-ou Shan

    PNAS May 7, 2013 110 (19) 7666-7671; https://doi.org/10.1073/pnas.1222054110
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    PCNA is efficiently loaded on the DNA recombination intermediate to modulate polymerase δ, η, and ζ activities

    Jian Li, Donald L. Holzschu, and Tomohiko Sugiyama

    PNAS May 7, 2013 110 (19) 7672-7677; https://doi.org/10.1073/pnas.1222241110
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    Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription

    Katie L. Pennington, Sharon K. Marr, Gung-Wei Chirn, and Michael T. Marr II

    PNAS May 7, 2013 110 (19) 7678-7683; https://doi.org/10.1073/pnas.1221712110

• Biophysics and Computational Biology

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    Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

    Wenbing Hu, Benjamin T. Walters, Zhong-Yuan Kan, Leland Mayne, Laura E. Rosen, Susan Marqusee, and S. Walter Englander

    PNAS May 7, 2013 110 (19) 7684-7689; https://doi.org/10.1073/pnas.1305887110
  • Open Access

    Mechanism of tyrosine D oxidation in Photosystem II

    Keisuke Saito, A. William Rutherford, and Hiroshi Ishikita

    PNAS May 7, 2013 110 (19) 7690-7695; https://doi.org/10.1073/pnas.1300817110
  • Open Access

    Transient formation of water-conducting states in membrane transporters

    Jing Li, Saher A. Shaikh, Giray Enkavi, Po-Chao Wen, Zhijian Huang, and Emad Tajkhorshid

    PNAS May 7, 2013 110 (19) 7696-7701; https://doi.org/10.1073/pnas.1218986110
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    Different 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediates

    Leonardus M. I. Koharudin, Lin Liu, and Angela M. Gronenborn

    PNAS May 7, 2013 110 (19) 7702-7707; https://doi.org/10.1073/pnas.1300327110

• Cell Biology

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    E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways

    Antonina Pechkovsky, Maoz Lahav, Eliya Bitman, Adi Salzberg, and Tamar Kleinberger

    PNAS May 7, 2013 110 (19) E1724-E1733; https://doi.org/10.1073/pnas.1220282110
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    Characterizing deformability and surface friction of cancer cells

    Sangwon Byun, Sungmin Son, Dario Amodei, Nathan Cermak, Josephine Shaw, Joon Ho Kang, Vivian C. Hecht, Monte M. Winslow, Tyler Jacks, Parag Mallick, and Scott R. Manalis

    PNAS May 7, 2013 110 (19) 7580-7585; https://doi.org/10.1073/pnas.1218806110
  • Open Access

    Long tethers provide high-force coupling of the Dam1 ring to shortening microtubules

    Vladimir A. Volkov, Anatoly V. Zaytsev, Nikita Gudimchuk, Paula M. Grissom, Alexander L. Gintsburg, Fazly I. Ataullakhanov, J. Richard McIntosh, and Ekaterina L. Grishchuk

    PNAS May 7, 2013 110 (19) 7708-7713; https://doi.org/10.1073/pnas.1305821110
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    Ancestral amphibian v2rs are expressed in the main olfactory epithelium

    Adnan S. Syed, Alfredo Sansone, Walter Nadler, Ivan Manzini, and Sigrun I. Korsching

    PNAS May 7, 2013 110 (19) 7714-7719; https://doi.org/10.1073/pnas.1302088110
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    Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

    Lan N. Truong, Yongjiang Li, Linda Z. Shi, Patty Yi-Hwa Hwang, Jing He, Hailong Wang, Niema Razavian, Michael W. Berns, and Xiaohua Wu

    PNAS May 7, 2013 110 (19) 7720-7725; https://doi.org/10.1073/pnas.1213431110
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    Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate

    Yuanfu Xu, Hongmei Li, Besnik Bajrami, Hyunjeong Kwak, Shannan Cao, Peng Liu, Jiaxi Zhou, Yuan Zhou, Haiyan Zhu, Keqiang Ye, and Hongbo R. Luo

    PNAS May 7, 2013 110 (19) 7726-7731; https://doi.org/10.1073/pnas.1302906110

• Developmental Biology

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    Castor is required for Hedgehog-dependent cell-fate specification and follicle stem cell maintenance in Drosophila oogenesis

    Yu-Chiuan Chang, Anna C.-C. Jang, Cheng-Han Lin, and Denise J. Montell

    PNAS May 7, 2013 110 (19) E1734-E1742; https://doi.org/10.1073/pnas.1300725110
  • Open Access

    Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis

    Chaeuk Chung, Tackhoon Kim, Miju Kim, Minchul Kim, Hoogeun Song, Tae-Shin Kim, Eunjeong Seo, Sang-Hee Lee, Hanbyul Kim, Sang Kyum Kim, Geon Yoo, Da-Hye Lee, Deog-Su Hwang, Tatsuo Kinashi, Jin-Man Kim, and Dae-Sik Lim

    PNAS May 7, 2013 110 (19) 7732-7737; https://doi.org/10.1073/pnas.1220603110

• Ecology

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    Centrality in primate–parasite networks reveals the potential for the transmission of emerging infectious diseases to humans

    José María Gómez, Charles L. Nunn, and Miguel Verdú

    PNAS May 7, 2013 110 (19) 7738-7741; https://doi.org/10.1073/pnas.1220716110
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    Organic-matter loading determines regime shifts and alternative states in an aquatic ecosystem

    Jennie Sirota, Benjamin Baiser, Nicholas J. Gotelli, and Aaron M. Ellison

    PNAS May 7, 2013 110 (19) 7742-7747; https://doi.org/10.1073/pnas.1221037110

• Environmental Sciences

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    Pre-Miocene birth of the Yangtze River

    • From the Cover

    Hongbo Zheng, Peter D. Clift, Ping Wang, Ryuji Tada, Juntao Jia, Mengying He, and Fred Jourdan

    PNAS May 7, 2013 110 (19) 7556-7561; https://doi.org/10.1073/pnas.1216241110

• Evolution

  • Open Access

    Genomic rearrangements and the evolution of clusters of locally adaptive loci

    Sam Yeaman

    PNAS May 7, 2013 110 (19) E1743-E1751; https://doi.org/10.1073/pnas.1219381110
  • Open Access

    Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes

    Bo Wu, Jacopo Novelli, Daojun Jiang, Harry A. Dailey, Frédéric Landmann, Louise Ford, Mark J. Taylor, Clotilde K. S. Carlow, Sanjay Kumar, Jeremy M. Foster, and Barton E. Slatko

    PNAS May 7, 2013 110 (19) 7748-7753; https://doi.org/10.1073/pnas.1304049110
  • Open Access

    Neutral forces acting on intragenomic variability shape the Escherichia coli regulatory network topology

    Troy Ruths and Luay Nakhleh

    PNAS May 7, 2013 110 (19) 7754-7759; https://doi.org/10.1073/pnas.1217630110
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    Diversification of the eutherian placenta is associated with changes in the pace of life

    Michael Garratt, Jean-Michel Gaillard, Robert C. Brooks, and Jean-François Lemaître

    PNAS May 7, 2013 110 (19) 7760-7765; https://doi.org/10.1073/pnas.1305018110
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    Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts

    Søren Damkiær, Lei Yang, Søren Molin, and Lars Jelsbak

    PNAS May 7, 2013 110 (19) 7766-7771; https://doi.org/10.1073/pnas.1221466110

• Genetics

  • Open Access

    Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain

    Yang Cao, Stanislava Chtarbanova, Andrew J. Petersen, and Barry Ganetzky

    PNAS May 7, 2013 110 (19) E1752-E1760; https://doi.org/10.1073/pnas.1306220110
  • Open Access

    Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells

    Patrick J. Murphy, Benjamin R. Cipriany, Christopher B. Wallin, Chan Yang Ju, Kylan Szeto, James A. Hagarman, Jaime J. Benitez, Harold G. Craighead, and Paul D. Soloway

    PNAS May 7, 2013 110 (19) 7772-7777; https://doi.org/10.1073/pnas.1218495110
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    Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

    • From the Cover

    Zihui Xu, Mickael Poidevin, Xuekun Li, Yujing Li, Liqi Shu, David L. Nelson, He Li, Chadwick M. Hales, Marla Gearing, Thomas S. Wingo, and Peng Jin

    PNAS May 7, 2013 110 (19) 7778-7783; https://doi.org/10.1073/pnas.1219643110

    See companion article:

    • ALS/FTD pathogenesis

      - Apr 29, 2013
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    Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation

    Masatoshi Aida, Nesreen Hamad, Andre Stanlie, Nasim A. Begum, and Tasuku Honjo

    PNAS May 7, 2013 110 (19) 7784-7789; https://doi.org/10.1073/pnas.1305859110
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    Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis

    Gina M. DeStefano, Katherine A. Fantauzzo, Lynn Petukhova, Mazen Kurban, Marija Tadin-Strapps, Brynn Levy, Dorothy Warburton, Elizabeth T. Cirulli, Yujun Han, Xiaoyun Sun, Yufeng Shen, Maryam Shirazi, Vaidehi Jobanputra, Rodrigo Cepeda-Valdes, Julio Cesar Salas-Alanis, and Angela M. Christiano

    PNAS May 7, 2013 110 (19) 7790-7795; https://doi.org/10.1073/pnas.1216412110
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    Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

    Nicolas F. Berbari, Raymond C. Pasek, Erik B. Malarkey, S. M. Zaki Yazdi, Andrew D. McNair, Wesley R. Lewis, Tim R. Nagy, Robert A. Kesterson, and Bradley K. Yoder

    PNAS May 7, 2013 110 (19) 7796-7801; https://doi.org/10.1073/pnas.1210192110

• Immunology

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    Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity

    Wangko Lundström, Steven Highfill, Scott T. R. Walsh, Stephanie Beq, Elizabeth Morse, Ingrid Kockum, Lars Alfredsson, Tomas Olsson, Jan Hillert, and Crystal L. Mackall

    PNAS May 7, 2013 110 (19) E1761-E1770; https://doi.org/10.1073/pnas.1222303110
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    The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins

    Jacinto López-Sagaseta, Charles L. Dulberger, James E. Crooks, Chelsea D. Parks, Adrienne M. Luoma, Amanda McFedries, Ildiko Van Rhijn, Alan Saghatelian, and Erin J. Adams

    PNAS May 7, 2013 110 (19) E1771-E1778; https://doi.org/10.1073/pnas.1222678110
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    Metallothioneins negatively regulate IL-27–induced type 1 regulatory T-cell differentiation

    Chuan Wu, Caroline Pot, Lionel Apetoh, Theresa Thalhamer, Bing Zhu, Gopal Murugaiyan, Sheng Xiao, Youjin Lee, Manu Rangachari, Nir Yosef, and Vijay K. Kuchroo

    PNAS May 7, 2013 110 (19) 7802-7807; https://doi.org/10.1073/pnas.1211776110
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    Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation

    Motti Gerlic, Benjamin Faustin, Antonio Postigo, Eric Chi-Wang Yu, Martina Proell, Naran Gombosuren, Maryla Krajewska, Rachel Flynn, Michael Croft, Michael Way, Arnold Satterthwait, Robert C. Liddington, Shahram Salek-Ardakani, Shu-ichi Matsuzawa, and John C. Reed

    PNAS May 7, 2013 110 (19) 7808-7813; https://doi.org/10.1073/pnas.1215995110
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    Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation

    Juan Liu, Shuxun Liu, Meng Xia, Sheng Xu, Chunmei Wang, Yan Bao, Minghong Jiang, Yue Wu, Tian Xu, and Xuetao Cao

    PNAS May 7, 2013 110 (19) 7814-7819; https://doi.org/10.1073/pnas.1220466110
  • Open Access

    Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

    Alessandro Michelucci, Thekla Cordes, Jenny Ghelfi, Arnaud Pailot, Norbert Reiling, Oliver Goldmann, Tina Binz, André Wegner, Aravind Tallam, Antonio Rausell, Manuel Buttini, Carole L. Linster, Eva Medina, Rudi Balling, and Karsten Hiller

    PNAS May 7, 2013 110 (19) 7820-7825; https://doi.org/10.1073/pnas.1218599110
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    Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation

    Norihito Kawasaki, Jose Luis Vela, Corwin M. Nycholat, Christoph Rademacher, Archana Khurana, Nico van Rooijen, Paul R. Crocker, Mitchell Kronenberg, and James C. Paulson

    PNAS May 7, 2013 110 (19) 7826-7831; https://doi.org/10.1073/pnas.1219888110
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    Characterization of pathogenic human monoclonal autoantibodies against GM-CSF

    Yanni Wang, Christy A. Thomson, Lenka L. Allan, Linda M. Jackson, Melanie Olson, Timothy R. Hercus, Tracy L. Nero, Amanda Turner, Michael W. Parker, Angel L. Lopez, Thomas K. Waddell, Gary P. Anderson, John A. Hamilton, and John W. Schrader

    PNAS May 7, 2013 110 (19) 7832-7837; https://doi.org/10.1073/pnas.1216011110

• Medical Sciences

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    Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

    Jiun-Ming Wu, Chiung-Tong Chen, Mohane Selvaraj Coumar, Wen-Hsin Lin, Zi-Jie Chen, John T.-A. Hsu, Yi-Hui Peng, Hui-Yi Shiao, Wen-Hsing Lin, Chang-Ying Chu, Jian-Sung Wu, Chih-Tsung Lin, Ching-Ping Chen, Ching-Cheng Hsueh, Kai-Yen Chang, Li-Pin Kao, Chi-Ying F. Huang, Yu-Sheng Chao, Su-Ying Wu, Hsing-Pang Hsieh, and Ya-Hui Chi

    PNAS May 7, 2013 110 (19) E1779-E1787; https://doi.org/10.1073/pnas.1220523110
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    Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis

    Guoxiang Yuan, Ying-Jie Peng, Vaddi Damodara Reddy, Vladislav V. Makarenko, Jayasri Nanduri, Shakil A. Khan, Joseph A. Garcia, Ganesh K. Kumar, Gregg L. Semenza, and Nanduri R. Prabhakar

    PNAS May 7, 2013 110 (19) E1788-E1796; https://doi.org/10.1073/pnas.1305961110
  • Open Access

    Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

    • From the Cover

    Shigeru Shibata, Junhui Zhang, Jeremy Puthumana, Kathryn L. Stone, and Richard P. Lifton

    PNAS May 7, 2013 110 (19) 7838-7843; https://doi.org/10.1073/pnas.1304592110

    See companion article:

    • Ubiquitination and electrolyte balance

      - Apr 23, 2013
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    Serum microRNA-122 level correlates with virologic responses to pegylated interferon therapy in chronic hepatitis C

    Tung-Hung Su, Chen-Hua Liu, Chun-Jen Liu, Chi-Ling Chen, Te-Tien Ting, Tai-Chung Tseng, Pei-Jer Chen, Jia-Horng Kao, and Ding-Shinn Chen

    PNAS May 7, 2013 110 (19) 7844-7849; https://doi.org/10.1073/pnas.1306138110
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    Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α

    Laura Fozzatti, Dong Wook Kim, Jeong Won Park, Mark C. Willingham, Anthony N. Hollenberg, and Sheue-Yann Cheng

    PNAS May 7, 2013 110 (19) 7850-7855; https://doi.org/10.1073/pnas.1222334110

• Microbiology

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    HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures

    • Inaugural Article

    Eun-Young Kho, Hsu-Kun Wang, N. Sanjib Banerjee, Thomas R. Broker, and Louise T. Chow

    PNAS May 7, 2013 110 (19) 7542-7549; https://doi.org/10.1073/pnas.1304855110
  • Open Access

    Rate enhancement of bacterial extracellular electron transport involves bound flavin semiquinones

    • From the Cover

    Akihiro Okamoto, Kazuhito Hashimoto, Kenneth H. Nealson, and Ryuhei Nakamura

    PNAS May 7, 2013 110 (19) 7856-7861; https://doi.org/10.1073/pnas.1220823110

    See companion article:

    • Extracellular electron transfer

      - Apr 29, 2013
  • Open Access

    Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

    Else M. Bijker, Guido J. H. Bastiaens, Anne C. Teirlinck, Geert-Jan van Gemert, Wouter Graumans, Marga van de Vegte-Bolmer, Rianne Siebelink-Stoter, Theo Arens, Karina Teelen, Wiebke Nahrendorf, Edmond J. Remarque, Will Roeffen, Annemieke Jansens, Dunja Zimmerman, Martijn Vos, Ben C. L. van Schaijk, Jorien Wiersma, André J. A. M. van der Ven, Quirijn de Mast, Lisette van Lieshout, Jaco J. Verweij, Cornelus C. Hermsen, Anja Scholzen, and Robert W. Sauerwein

    PNAS May 7, 2013 110 (19) 7862-7867; https://doi.org/10.1073/pnas.1220360110
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    Conserved glycolipid termini in capsular polysaccharides synthesized by ATP-binding cassette transporter-dependent pathways in Gram-negative pathogens

    Lisa M. Willis, Jacek Stupak, Michele R. Richards, Todd L. Lowary, Jianjun Li, and Chris Whitfield

    PNAS May 7, 2013 110 (19) 7868-7873; https://doi.org/10.1073/pnas.1222317110
  • Open Access

    The c-ring stoichiometry of ATP synthase is adapted to cell physiological requirements of alkaliphilic Bacillus pseudofirmus OF4

    Laura Preiss, Adriana L. Klyszejko, David B. Hicks, Jun Liu, Oliver J. Fackelmayer, Özkan Yildiz, Terry A. Krulwich, and Thomas Meier

    PNAS May 7, 2013 110 (19) 7874-7879; https://doi.org/10.1073/pnas.1303333110

• Neuroscience

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    Mapping remodeling of thalamocortical projections in the living reeler mouse brain by diffusion tractography

    Laura-Adela Harsan, Csaba Dávid, Marco Reisert, Susanne Schnell, Jürgen Hennig, Dominik von Elverfeldt, and Jochen F. Staiger

    PNAS May 7, 2013 110 (19) E1797-E1806; https://doi.org/10.1073/pnas.1218330110
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    ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

    Philip B. Verghese, Joseph M. Castellano, Kanchan Garai, Yinong Wang, Hong Jiang, Aarti Shah, Guojun Bu, Carl Frieden, and David M. Holtzman

    PNAS May 7, 2013 110 (19) E1807-E1816; https://doi.org/10.1073/pnas.1220484110
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    TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

    Mickael Decressac, Bengt Mattsson, Pia Weikop, Martin Lundblad, Johan Jakobsson, and Anders Björklund

    PNAS May 7, 2013 110 (19) E1817-E1826; https://doi.org/10.1073/pnas.1305623110
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    Phase transition in the economically modeled growth of a cellular nervous system

    Vincenzo Nicosia, Petra E. Vértes, William R. Schafer, Vito Latora, and Edward T. Bullmore

    PNAS May 7, 2013 110 (19) 7880-7885; https://doi.org/10.1073/pnas.1300753110
  • Open Access

    Origin of intrinsic irregular firing in cortical interneurons

    Klaus M. Stiefel, Bernhard Englitz, and Terrence J. Sejnowski

    PNAS May 7, 2013 110 (19) 7886-7891; https://doi.org/10.1073/pnas.1305219110
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    Analogues of simple and complex cells in rhesus monkey auditory cortex

    Biao Tian, Paweł Kuśmierek, and Josef P. Rauschecker

    PNAS May 7, 2013 110 (19) 7892-7897; https://doi.org/10.1073/pnas.1221062110
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    Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation

    Tsung-Pin Pai, Chun-Chao Chen, Hui-Hao Lin, An-Lun Chin, Jason Sih-Yu Lai, Pei-Tseng Lee, Tim Tully, and Ann-Shyn Chiang

    PNAS May 7, 2013 110 (19) 7898-7903; https://doi.org/10.1073/pnas.1216336110
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    Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

    Hong Xie, Steven Hou, Jun Jiang, Maria Sekutowicz, Jonathan Kelly, and Brian J. Bacskai

    PNAS May 7, 2013 110 (19) 7904-7909; https://doi.org/10.1073/pnas.1217938110
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    Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator

    Ioannis Zalachoras, René Houtman, Erika Atucha, Rene Devos, Ans M. I. Tijssen, Pu Hu, Peter M. Lockey, Nicole A. Datson, Joseph K. Belanoff, Paul J. Lucassen, Marian Joëls, E. Ronald de Kloet, Benno Roozendaal, Hazel Hunt, and Onno C. Meijer

    PNAS May 7, 2013 110 (19) 7910-7915; https://doi.org/10.1073/pnas.1219411110
  • Open Access

    Modulation of the endoplasmic reticulum–mitochondria interface in Alzheimer’s disease and related models

    Louise Hedskog, Catarina Moreira Pinho, Riccardo Filadi, Annica Rönnbäck, Laura Hertwig, Birgitta Wiehager, Pia Larssen, Sandra Gellhaar, Anna Sandebring, Marie Westerlund, Caroline Graff, Bengt Winblad, Dagmar Galter, Homira Behbahani, Paola Pizzo, Elzbieta Glaser, and Maria Ankarcrona

    PNAS May 7, 2013 110 (19) 7916-7921; https://doi.org/10.1073/pnas.1300677110

• Pharmacology

  • Open Access

    Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

    Sarah K. Knutson, Natalie M. Warholic, Tim J. Wigle, Christine R. Klaus, Christina J. Allain, Alejandra Raimondi, Margaret Porter Scott, Richard Chesworth, Mikel P. Moyer, Robert A. Copeland, Victoria M. Richon, Roy M. Pollock, Kevin W. Kuntz, and Heike Keilhack

    PNAS May 7, 2013 110 (19) 7922-7927; https://doi.org/10.1073/pnas.1303800110

• Physiology

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    Renal intercalated cells are rather energized by a proton than a sodium pump

    Régine Chambrey, Ingo Kurth, Janos Peti-Peterdi, Pascal Houillier, Jeffrey M. Purkerson, Françoise Leviel, Moritz Hentschke, Anselm A. Zdebik, George J. Schwartz, Christian A. Hübner, and Dominique Eladari

    PNAS May 7, 2013 110 (19) 7928-7933; https://doi.org/10.1073/pnas.1221496110

• Plant Biology

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    Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm

    Paolo A. Sabelli, Yan Liu, Ricardo A. Dante, Lucina E. Lizarraga, Hong N. Nguyen, Sara W. Brown, John P. Klingler, Jingjuan Yu, Evan LaBrant, Tracy M. Layton, Max Feldman, and Brian A. Larkins

    PNAS May 7, 2013 110 (19) E1827-E1836; https://doi.org/10.1073/pnas.1304903110
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    Imprinted expression of genes and small RNA is associated with localized hypomethylation of the maternal genome in rice endosperm

    Jessica A. Rodrigues, Randy Ruan, Toshiro Nishimura, Manoj K. Sharma, Rita Sharma, Pamela C. Ronald, Robert L. Fischer, and Daniel Zilberman

    PNAS May 7, 2013 110 (19) 7934-7939; https://doi.org/10.1073/pnas.1306164110
  • Open Access

    A 4-gigabase physical map unlocks the structure and evolution of the complex genome of Aegilops tauschii, the wheat D-genome progenitor

    Ming-Cheng Luo, Yong Q. Gu, Frank M. You, Karin R. Deal, Yaqin Ma, Yuqin Hu, Naxin Huo, Yi Wang, Jirui Wang, Shiyong Chen, Chad M. Jorgensen, Yong Zhang, Patrick E. McGuire, Shiran Pasternak, Joshua C. Stein, Doreen Ware, Melissa Kramer, W. Richard McCombie, Shahryar F. Kianian, Mihaela M. Martis, Klaus F. X. Mayer, Sunish K. Sehgal, Wanlong Li, Bikram S. Gill, Michael W. Bevan, Hana Šimková, Jaroslav Doležel, Song Weining, Gerard R. Lazo, Olin D. Anderson, and Jan Dvorak

    PNAS May 7, 2013 110 (19) 7940-7945; https://doi.org/10.1073/pnas.1219082110
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    Salicylic acid interferes with clathrin-mediated endocytic protein trafficking

    Yunlong Du, Ricardo Tejos, Martina Beck, Ellie Himschoot, Hongjiang Li, Silke Robatzek, Steffen Vanneste, and Jiří Friml

    PNAS May 7, 2013 110 (19) 7946-7951; https://doi.org/10.1073/pnas.1220205110

• Population Biology

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    Cost-effectiveness of a community-based intervention for reducing the transmission of Schistosoma haematobium and HIV in Africa

    Martial L. Ndeffo Mbah, Eyrun F. Kjetland, Katherine E. Atkins, Eric M. Poolman, Evan W. Orenstein, Lauren Ancel Meyers, Jeffrey P. Townsend, and Alison P. Galvani

    PNAS May 7, 2013 110 (19) 7952-7957; https://doi.org/10.1073/pnas.1221396110

• Sustainability Science

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    Agricultural intensification escalates future conservation costs

    Jacob Phelps, Luis Roman Carrasco, Edward L. Webb, Lian Pin Koh, and Unai Pascual

    PNAS May 7, 2013 110 (19) 7601-7606; https://doi.org/10.1073/pnas.1220070110