Table of Contents

Biological Sciences

• Agricultural Sciences

  • Open Access

    A link between host plant adaptation and pesticide resistance in the polyphagous spider mite Tetranychus urticae

    Wannes Dermauw, Nicky Wybouw, Stephane Rombauts, Björn Menten, John Vontas, Miodrag Grbić, Richard M. Clark, René Feyereisen, and Thomas Van Leeuwen

    PNAS January 8, 2013 110 (2) E113-E122; https://doi.org/10.1073/pnas.1213214110
  • Open Access

    Population genomic and genome-wide association studies of agroclimatic traits in sorghum

    Geoffrey P. Morris, Punna Ramu, Santosh P. Deshpande, C. Thomas Hash, Trushar Shah, Hari D. Upadhyaya, Oscar Riera-Lizarazu, Patrick J. Brown, Charlotte B. Acharya, Sharon E. Mitchell, James Harriman, Jeffrey C. Glaubitz, Edward S. Buckler, and Stephen Kresovich

    PNAS January 8, 2013 110 (2) 453-458; https://doi.org/10.1073/pnas.1215985110

• Applied Biological Sciences

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    Reverse-engineering the genetic circuitry of a cancer cell with predicted intervention in chronic lymphocytic leukemia

    Laurent Vallat, Corey A. Kemper, Nicolas Jung, Myriam Maumy-Bertrand, Frédéric Bertrand, Nicolas Meyer, Arnaud Pocheville, John W. Fisher III, John G. Gribben, and Seiamak Bahram

    PNAS January 8, 2013 110 (2) 459-464; https://doi.org/10.1073/pnas.1211130110
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    pHLIP peptide targets nanogold particles to tumors

    Lan Yao, Jennifer Daniels, Anna Moshnikova, Sergey Kuznetsov, Aftab Ahmed, Donald M. Engelman, Yana K. Reshetnyak, and Oleg A. Andreev

    PNAS January 8, 2013 110 (2) 465-470; https://doi.org/10.1073/pnas.1219665110
  • Open Access

    Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications

    Jaqueline S. Soares, Ishan Barman, Narahara Chari Dingari, Zoya Volynskaya, Wendy Liu, Nina Klein, Donna Plecha, Ramachandra R. Dasari, and Maryann Fitzmaurice

    PNAS January 8, 2013 110 (2) 471-476; https://doi.org/10.1073/pnas.1215473110
  • Open Access

    Proteome-wide protein interaction measurements of bacterial proteins of unknown function

    Matthias Meier, Rene V. Sit, and Stephen R. Quake

    PNAS January 8, 2013 110 (2) 477-482; https://doi.org/10.1073/pnas.1210634110

• Biochemistry

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    HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold

    Seemay Chou, Heather Upton, Katherine Bao, Ursula Schulze-Gahmen, Avi J. Samelson, Nanhai He, Anna Nowak, Huasong Lu, Nevan J. Krogan, Qiang Zhou, and Tom Alber

    PNAS January 8, 2013 110 (2) E123-E131; https://doi.org/10.1073/pnas.1216971110
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    Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity

    • Inaugural Article

    Eonyoung Park, Michael L. Gleghorn, and Lynne E. Maquat

    PNAS January 8, 2013 110 (2) 405-412; https://doi.org/10.1073/pnas.1213508110
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    Electronic structure of the unique [4Fe-3S] cluster in O₂-tolerant hydrogenases characterized by ⁵⁷Fe Mössbauer and EPR spectroscopy

    Maria-Eirini Pandelia, Dmytro Bykov, Robert Izsak, Pascale Infossi, Marie-Thérèse Giudici-Orticoni, Eckhard Bill, Frank Neese, and Wolfgang Lubitz

    PNAS January 8, 2013 110 (2) 483-488; https://doi.org/10.1073/pnas.1202575110

    See companion article:

    • DFT electronic structure of [4Fe-3S] cluster

      - May 28, 2013
  • Open Access

    M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

    Marta Cortés-Cros, Christelle Hemmerlin, Stephane Ferretti, Juan Zhang, John S. Gounarides, Hong Yin, Alban Muller, Anne Haberkorn, Patrick Chene, William R. Sellers, and Francesco Hofmann

    PNAS January 8, 2013 110 (2) 489-494; https://doi.org/10.1073/pnas.1212780110

• Biophysics and Computational Biology

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    In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome

    Prajwal Ciryam, Richard I. Morimoto, Michele Vendruscolo, Christopher M. Dobson, and Edward P. O’Brien

    PNAS January 8, 2013 110 (2) E132-E140; https://doi.org/10.1073/pnas.1213624110
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    Exploring the nature of the translocon-assisted protein insertion

    Anna Rychkova and Arieh Warshel

    PNAS January 8, 2013 110 (2) 495-500; https://doi.org/10.1073/pnas.1220361110
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    Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors

    Ken’ya Furuta, Akane Furuta, Yoko Y. Toyoshima, Misako Amino, Kazuhiro Oiwa, and Hiroaki Kojima

    PNAS January 8, 2013 110 (2) 501-506; https://doi.org/10.1073/pnas.1201390110
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    Marked changes in electron transport through the blue copper protein azurin in the solid state upon deuteration

    Nadav Amdursky, Israel Pecht, Mordechai Sheves, and David Cahen

    PNAS January 8, 2013 110 (2) 507-512; https://doi.org/10.1073/pnas.1210457110
  • Open Access

    Molecular structures of trimeric HIV-1 Env in complex with small antibody derivatives

    Joel R. Meyerson, Erin E. H. Tran, Oleg Kuybeda, Weizao Chen, Dimiter S. Dimitrov, Andrea Gorlani, Theo Verrips, Jeffrey D. Lifson, and Sriram Subramaniam

    PNAS January 8, 2013 110 (2) 513-518; https://doi.org/10.1073/pnas.1214810110
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    Aliphatic peptides show similar self-assembly to amyloid core sequences, challenging the importance of aromatic interactions in amyloidosis

    Anupama Lakshmanan, Daniel W. Cheong, Angelo Accardo, Enzo Di Fabrizio, Christian Riekel, and Charlotte A. E. Hauser

    PNAS January 8, 2013 110 (2) 519-524; https://doi.org/10.1073/pnas.1217742110

• Cell Biology

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    α2 and α3 helices of dystrophin R16 and R17 frame a microdomain in the α1 helix of dystrophin R17 for neuronal NOS binding

    • From the Cover

    Yi Lai, Junling Zhao, Yongping Yue, and Dongsheng Duan

    PNAS January 8, 2013 110 (2) 525-530; https://doi.org/10.1073/pnas.1211431109

    See companion article:

    • Pinpointing the nNOS binding site in dystrophin

      - Dec 31, 2012
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    Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes

    Robert W. Moon, Joanna Hall, Farania Rangkuti, Yung Shwen Ho, Neil Almond, Graham H. Mitchell, Arnab Pain, Anthony A. Holder, and Michael J. Blackman

    PNAS January 8, 2013 110 (2) 531-536; https://doi.org/10.1073/pnas.1216457110

• Developmental Biology

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    Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition

    Peter Geon Kim, Colleen E. Albacker, Yi-fen Lu, Il-ho Jang, Yoowon Lim, Garrett C. Heffner, Natasha Arora, Teresa V. Bowman, Michelle I. Lin, M. William Lensch, Alejandro De Los Angeles, Leonard I. Zon, Sabine Loewer, and George Q. Daley

    PNAS January 8, 2013 110 (2) E141-E150; https://doi.org/10.1073/pnas.1214361110
  • Open Access

    Maternal exposure to bisphenol A and genistein has minimal effect on A^vy/a offspring coat color but favors birth of agouti over nonagouti mice

    Cheryl S. Rosenfeld, Paizlee T. Sieli, Denise A. Warzak, Mark R. Ellersieck, Kathleen A. Pennington, and R. Michael Roberts

    PNAS January 8, 2013 110 (2) 537-542; https://doi.org/10.1073/pnas.1220230110
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    Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males

    Ming-Han Tong, Qi-En Yang, Jeffrey C. Davis, and Michael D. Griswold

    PNAS January 8, 2013 110 (2) 543-548; https://doi.org/10.1073/pnas.1214883110
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    Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice

    Jessica Momb, Jordan P. Lewandowski, Joshua D. Bryant, Rebecca Fitch, Deborah R. Surman, Steven A. Vokes, and Dean R. Appling

    PNAS January 8, 2013 110 (2) 549-554; https://doi.org/10.1073/pnas.1211199110

• Ecology

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    Resource diversity and landscape-level homogeneity drive native bee foraging

    Shalene Jha and Claire Kremen

    PNAS January 8, 2013 110 (2) 555-558; https://doi.org/10.1073/pnas.1208682110

    See companion article:

    • In This Issue

      - Jan 08, 2013

• Environmental Sciences

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    A continuous climatic impact on Holocene human population in the Rocky Mountains

    Robert L. Kelly, Todd A. Surovell, Bryan N. Shuman, and Geoffrey M. Smith

    PNAS January 8, 2013 110 (2) 443-447; https://doi.org/10.1073/pnas.1201341110
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    Potential impact of microbial activity on the oxidant capacity and organic carbon budget in clouds

    Mickael Vaïtilingom, Laurent Deguillaume, Virginie Vinatier, Martine Sancelme, Pierre Amato, Nadine Chaumerliac, and Anne-Marie Delort

    PNAS January 8, 2013 110 (2) 559-564; https://doi.org/10.1073/pnas.1205743110
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    Persistent effects of a severe drought on Amazonian forest canopy

    Sassan Saatchi, Salvi Asefi-Najafabady, Yadvinder Malhi, Luiz E. O. C. Aragão, Liana O. Anderson, Ranga B. Myneni, and Ramakrishna Nemani

    PNAS January 8, 2013 110 (2) 565-570; https://doi.org/10.1073/pnas.1204651110

• Evolution

  • Open Access

    Genealogies of rapidly adapting populations

    Richard A. Neher and Oskar Hallatschek

    PNAS January 8, 2013 110 (2) 437-442; https://doi.org/10.1073/pnas.1213113110
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    Predictability of evolution depends nonmonotonically on population size

    Ivan G. Szendro, Jasper Franke, J. Arjan G. M. de Visser, and Joachim Krug

    PNAS January 8, 2013 110 (2) 571-576; https://doi.org/10.1073/pnas.1213613110
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    Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis

    Yujun Cui, Chang Yu, Yanfeng Yan, Dongfang Li, Yanjun Li, Thibaut Jombart, Lucy A. Weinert, Zuyun Wang, Zhaobiao Guo, Lizhi Xu, Yujiang Zhang, Hancheng Zheng, Nan Qin, Xiao Xiao, Mingshou Wu, Xiaoyi Wang, Dongsheng Zhou, Zhizhen Qi, Zongmin Du, Honglong Wu, Xianwei Yang, Hongzhi Cao, Hu Wang, Jing Wang, Shusen Yao, Alexander Rakin, Yingrui Li, Daniel Falush, Francois Balloux, Mark Achtman, Yajun Song, Jun Wang, and Ruifu Yang

    PNAS January 8, 2013 110 (2) 577-582; https://doi.org/10.1073/pnas.1205750110
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    Laccase detoxification mediates the nutritional alliance between leaf-cutting ants and fungus-garden symbionts

    Henrik H. De Fine Licht, Morten Schiøtt, Adelina Rogowska-Wrzesinska, Sanne Nygaard, Peter Roepstorff, and Jacobus J. Boomsma

    PNAS January 8, 2013 110 (2) 583-587; https://doi.org/10.1073/pnas.1212709110

• Genetics

  • Open Access

    Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association

    Karl C. Desch, Ayse B. Ozel, David Siemieniak, Yossi Kalish, Jordan A. Shavit, Courtney D. Thornburg, Anjali A. Sharathkumar, Caitlin P. McHugh, Cathy C. Laurie, Andrew Crenshaw, Daniel B. Mirel, Yoonhee Kim, Cheryl D. Cropp, Anne M. Molloy, Peadar N. Kirke, Joan E. Bailey-Wilson, Alexander F. Wilson, James L. Mills, John M. Scott, Lawrence C. Brody, Jun Z. Li, and David Ginsburg

    PNAS January 8, 2013 110 (2) 588-593; https://doi.org/10.1073/pnas.1219885110
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    Two methods for full-length RNA sequencing for low quantities of cells and single cells

    Xinghua Pan, Russell E. Durrett, Haiying Zhu, Yoshiaki Tanaka, Yumei Li, Xiaoyuan Zi, Sadie L. Marjani, Ghia Euskirchen, Chao Ma, Robert H. LaMotte, In-Hyun Park, Michael P. Snyder, Christopher E. Mason, and Sherman M. Weissman

    PNAS January 8, 2013 110 (2) 594-599; https://doi.org/10.1073/pnas.1217322109
  • Open Access

    Recombination regulator PRDM9 influences the instability of its own coding sequence in humans

    Alec J. Jeffreys, Victoria E. Cotton, Rita Neumann, and Kwan-Wood Gabriel Lam

    PNAS January 8, 2013 110 (2) 600-605; https://doi.org/10.1073/pnas.1220813110
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    Cell cycle-dependent deposition of CENP-A requires the Dos1/2–Cdc20 complex

    Marlyn Gonzalez, Haijin He, Siyu Sun, Chen Li, and Fei Li

    PNAS January 8, 2013 110 (2) 606-611; https://doi.org/10.1073/pnas.1214874110

• Immunology

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    Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations

    Shizue Tani-ichi, Akihiro Shimba, Keisuke Wagatsuma, Hitoshi Miyachi, Satsuki Kitano, Kumiko Imai, Takahiro Hara, and Koichi Ikuta

    PNAS January 8, 2013 110 (2) 612-617; https://doi.org/10.1073/pnas.1219242110
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    Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription

    Amy Colleran, Patricia E. Collins, Christine O’Carroll, Abrar Ahmed, Xicheng Mao, Bettina McManus, Patrick A. Kiely, Ezra Burstein, and Ruaidhrí J. Carmody

    PNAS January 8, 2013 110 (2) 618-623; https://doi.org/10.1073/pnas.1208446110
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    Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling

    Hyung-seung Jin, Lujian Liao, Yoon Park, and Yun-Cai Liu

    PNAS January 8, 2013 110 (2) 624-629; https://doi.org/10.1073/pnas.1213819110

• Medical Sciences

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    Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer

    Chien-Yu Chen, Yi-Hua Jan, Yi-Hsiu Juan, Chih-Jen Yang, Ming-Shyan Huang, Chong-Jen Yu, Pan-Chyr Yang, Michael Hsiao, Tsui-Ling Hsu, and Chi-Huey Wong

    PNAS January 8, 2013 110 (2) 630-635; https://doi.org/10.1073/pnas.1220425110
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    Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease

    Arthur G. Fitzmaurice, Shannon L. Rhodes, Aaron Lulla, Niall P. Murphy, Hoa A. Lam, Kelley C. O’Donnell, Lisa Barnhill, John E. Casida, Myles Cockburn, Alvaro Sagasti, Mark C. Stahl, Nigel T. Maidment, Beate Ritz, and Jeff M. Bronstein

    PNAS January 8, 2013 110 (2) 636-641; https://doi.org/10.1073/pnas.1220399110
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    Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation

    Mayurranjan S. Mitra, Zhouji Chen, Hongmei Ren, Thurl E. Harris, Kari T. Chambers, Angela M. Hall, Karim Nadra, Samuel Klein, Roman Chrast, Xiong Su, Andrew J. Morris, and Brian N. Finck

    PNAS January 8, 2013 110 (2) 642-647; https://doi.org/10.1073/pnas.1213493110
  • Open Access

    Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66^Shc

    Fabian Bock, Khurrum Shahzad, Hongjie Wang, Stoyan Stoyanov, Juliane Wolter, Wei Dong, Pier Giuseppe Pelicci, Muhammed Kashif, Satish Ranjan, Simone Schmidt, Robert Ritzel, Vedat Schwenger, Klaus G. Reymann, Charles T. Esmon, Thati Madhusudhan, Peter P. Nawroth, and Berend Isermann

    PNAS January 8, 2013 110 (2) 648-653; https://doi.org/10.1073/pnas.1218667110
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    Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs

    Eva-Maria Eleonora Hedlund, Xiaojuan Yang, Yin Zhang, Yunlong Yang, Masabumi Shibuya, Weide Zhong, Baocun Sun, Yizhi Liu, Kayoko Hosaka, and Yihai Cao

    PNAS January 8, 2013 110 (2) 654-659; https://doi.org/10.1073/pnas.1209310110
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    Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction

    Makoto Kudo, S. M. Amin Khalifeh Soltani, Stephen A. Sakuma, William McKleroy, Ting-Hein Lee, Prescott G. Woodruff, Jae Woo Lee, Katherine Huang, Chun Chen, Mehrdad Arjomandi, Xiaozhu Huang, and Kamran Atabai

    PNAS January 8, 2013 110 (2) 660-665; https://doi.org/10.1073/pnas.1216673110

• Microbiology

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    ATP hydrolysis by a domain related to translation factor GTPases drives polymerization of a static bacterial morphogenetic protein

    Jean-Philippe Castaing, Attila Nagy, Vivek Anantharaman, L. Aravind, and Kumaran S. Ramamurthi

    PNAS January 8, 2013 110 (2) E151-E160; https://doi.org/10.1073/pnas.1210554110
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    Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems

    Guy E. Townsend II, Varsha Raghavan, Igor Zwir, and Eduardo A. Groisman

    PNAS January 8, 2013 110 (2) E161-E169; https://doi.org/10.1073/pnas.1212102110
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    Growth of Carnobacterium spp. from permafrost under low pressure, temperature, and anoxic atmosphere has implications for Earth microbes on Mars

    • From the Cover

    Wayne L. Nicholson, Kirill Krivushin, David Gilichinsky, and Andrew C. Schuerger

    PNAS January 8, 2013 110 (2) 666-671; https://doi.org/10.1073/pnas.1209793110

    See companion article:

    • In This Issue

      - Jan 08, 2013
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    Probing kinase and phosphatase activities of two-component systems in vivo with concentration-dependent phosphorylation profiling

    Rong Gao and Ann M. Stock

    PNAS January 8, 2013 110 (2) 672-677; https://doi.org/10.1073/pnas.1214587110
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    Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals

    Xiaozhen Hu, Jinlei Zhao, William F. DeGrado, and Andrew N. Binns

    PNAS January 8, 2013 110 (2) 678-683; https://doi.org/10.1073/pnas.1215033110

• Neuroscience

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    High-order feature-based mixture models of classification learning predict individual learning curves and enable personalized teaching

    Yarden Cohen and Elad Schneidman

    PNAS January 8, 2013 110 (2) 684-689; https://doi.org/10.1073/pnas.1211606110
  • Open Access

    Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db⁻/db⁻ mouse, a type 2 diabetes model

    Tie-Jun Sten Shi, Ming-Dong Zhang, Hugo Zeberg, Johanna Nilsson, Jacob Grünler, Su-Xing Liu, Qiong Xiang, Jonas Persson, Kaj J. Fried, Sergiu Bogdan Catrina, Masahiko Watanabe, Peter Århem, Kerstin Brismar, and Tomas G. M. Hökfelt

    PNAS January 8, 2013 110 (2) 690-695; https://doi.org/10.1073/pnas.1220794110
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    Eight pairs of descending visual neurons in the dragonfly give wing motor centers accurate population vector of prey direction

    • From the Cover
    • Cozzarelli Prize Winner

    Paloma T. Gonzalez-Bellido, Hanchuan Peng, Jinzhu Yang, Apostolos P. Georgopoulos, and Robert M. Olberg

    PNAS January 8, 2013 110 (2) 696-701; https://doi.org/10.1073/pnas.1210489109

    See companion article:

    • Robust prey detection in a small nervous system

      - Dec 24, 2012
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    Blink-related momentary activation of the default mode network while viewing videos

    • From the Cover

    Tamami Nakano, Makoto Kato, Yusuke Morito, Seishi Itoi, and Shigeru Kitazawa

    PNAS January 8, 2013 110 (2) 702-706; https://doi.org/10.1073/pnas.1214804110

    See companion article:

    • In This Issue

      - Jan 08, 2013
  • Open Access

    Eye opening and PSD95 are required for long-term potentiation in developing superior colliculus

    Jian-Ping Zhao, Yasunobu Murata, and Martha Constantine-Paton

    PNAS January 8, 2013 110 (2) 707-712; https://doi.org/10.1073/pnas.1215854110
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    Selective presynaptic enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine

    Anna Suska, Brian R. Lee, Yanhua H. Huang, Yan Dong, and Oliver M. Schlüter

    PNAS January 8, 2013 110 (2) 713-718; https://doi.org/10.1073/pnas.1206287110
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    Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony

    Carola Sales-Carbonell, Pavel E. Rueda-Orozco, Edgar Soria-Gómez, György Buzsáki, Giovanni Marsicano, and David Robbe

    PNAS January 8, 2013 110 (2) 719-724; https://doi.org/10.1073/pnas.1217144110
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    Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling

    Elaine C. Budreck, Oh-Bin Kwon, Jung Hoon Jung, Stephane Baudouin, Albert Thommen, Hye-Sun Kim, Yugo Fukazawa, Harumi Harada, Katsuhiko Tabuchi, Ryuichi Shigemoto, Peter Scheiffele, and Joung-Hun Kim

    PNAS January 8, 2013 110 (2) 725-730; https://doi.org/10.1073/pnas.1214718110

• Pharmacology

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    Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis

    Aditi Bhargava, Matthew S. Clifton, Pallavi Mhaske, Min Liao, Charalabos Pothoulakis, Susan E. Leeman, and Eileen F. Grady

    PNAS January 8, 2013 110 (2) 731-736; https://doi.org/10.1073/pnas.1219733110
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    Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [¹¹C]ABP688 positron emission tomography

    Funda Akkus, Simon M. Ametamey, Valerie Treyer, Cyrill Burger, Anass Johayem, Daniel Umbricht, Baltazar Gomez Mancilla, Judit Sovago, Alfred Buck, and Gregor Hasler

    PNAS January 8, 2013 110 (2) 737-742; https://doi.org/10.1073/pnas.1210984110

    See companion article:

    • In This Issue

      - Jan 08, 2013
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    Single-molecule analysis of fluorescently labeled G-protein–coupled receptors reveals complexes with distinct dynamics and organization

    Davide Calebiro, Finn Rieken, Julia Wagner, Titiwat Sungkaworn, Ulrike Zabel, Alfio Borzi, Emanuele Cocucci, Alexander Zürn, and Martin J. Lohse

    PNAS January 8, 2013 110 (2) 743-748; https://doi.org/10.1073/pnas.1205798110

• Physiology

  • Open Access

    Amphipathic antenna of an inward rectifier K⁺ channel responds to changes in the inner membrane leaflet

    Masayuki Iwamoto and Shigetoshi Oiki

    PNAS January 8, 2013 110 (2) 749-754; https://doi.org/10.1073/pnas.1217323110

• Plant Biology

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    Unifying model of shoot gravitropism reveals proprioception as a central feature of posture control in plants

    • From the Cover

    Renaud Bastien, Tomas Bohr, Bruno Moulia, and Stéphane Douady

    PNAS January 8, 2013 110 (2) 755-760; https://doi.org/10.1073/pnas.1214301109

    See companion article:

    • Beyond the sine law of plant gravitropism

      - Dec 28, 2012
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    Transcriptional corepressor TOPLESS complexes with pseudoresponse regulator proteins and histone deacetylases to regulate circadian transcription

    Lei Wang, Jeongsik Kim, and David E. Somers

    PNAS January 8, 2013 110 (2) 761-766; https://doi.org/10.1073/pnas.1215010110
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    TAWAWA1, a regulator of rice inflorescence architecture, functions through the suppression of meristem phase transition

    Akiko Yoshida, Masafumi Sasao, Naoko Yasuno, Kyoko Takagi, Yasufumi Daimon, Ruihong Chen, Ryo Yamazaki, Hiroki Tokunaga, Yoshinori Kitaguchi, Yutaka Sato, Yoshiaki Nagamura, Tomokazu Ushijima, Toshihiro Kumamaru, Shigeru Iida, Masahiko Maekawa, and Junko Kyozuka

    PNAS January 8, 2013 110 (2) 767-772; https://doi.org/10.1073/pnas.1216151110
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    AtABCA9 transporter supplies fatty acids for lipid synthesis to the endoplasmic reticulum

    Sangwoo Kim, Yasuyo Yamaoka, Hirofumi Ono, Hanul Kim, Donghwan Shim, Masayoshi Maeshima, Enrico Martinoia, Edgar B. Cahoon, Ikuo Nishida, and Youngsook Lee

    PNAS January 8, 2013 110 (2) 773-778; https://doi.org/10.1073/pnas.1214159110
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    Arabidopsis Pumilio protein APUM5 suppresses Cucumber mosaic virus infection via direct binding of viral RNAs

    Sung Un Huh, Min Jung Kim, and Kyung-Hee Paek

    PNAS January 8, 2013 110 (2) 779-784; https://doi.org/10.1073/pnas.1214287110

• Psychological and Cognitive Sciences

  • Open Access

    Learning to detect and combine the features of an object

    Jordan W. Suchow and Denis G. Pelli

    PNAS January 8, 2013 110 (2) 785-790; https://doi.org/10.1073/pnas.1218438110

• Systems Biology

  • Open Access

    Defining principles of combination drug mechanisms of action

    Justin R. Pritchard, Peter M. Bruno, Luke A. Gilbert, Kelsey L. Capron, Douglas A. Lauffenburger, and Michael T. Hemann

    PNAS January 8, 2013 110 (2) E170-E179; https://doi.org/10.1073/pnas.1210419110
  • Open Access

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