Table of Contents

Biological Sciences

• Agricultural Sciences

  • Open Access

    Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars

    Colin R. Cavanagh, Shiaoman Chao, Shichen Wang, Bevan Emma Huang, Stuart Stephen, Seifollah Kiani, Kerrie Forrest, Cyrille Saintenac, Gina L. Brown-Guedira, Alina Akhunova, Deven See, Guihua Bai, Michael Pumphrey, Luxmi Tomar, Debbie Wong, Stephan Kong, Matthew Reynolds, Marta Lopez da Silva, Harold Bockelman, Luther Talbert, James A. Anderson, Susanne Dreisigacker, Stephen Baenziger, Arron Carter, Viktor Korzun, Peter Laurent Morrell, Jorge Dubcovsky, Matthew K. Morell, Mark E. Sorrells, Matthew J. Hayden, and Eduard Akhunov

    PNAS May 14, 2013 110 (20) 8057-8062; https://doi.org/10.1073/pnas.1217133110

• Anthropology

  • You have access

    Ash from the Toba supereruption in Lake Malawi shows no volcanic winter in East Africa at 75 ka

    Christine S. Lane, Ben T. Chorn, and Thomas C. Johnson

    PNAS May 14, 2013 110 (20) 8025-8029; https://doi.org/10.1073/pnas.1301474110

    See companion article:

    • Subdecadal climate record of the Toba eruption

      - Jun 21, 2013
  • You have access

    A model comparison approach shows stronger support for economic models of fertility decline

    Mary K. Shenk, Mary C. Towner, Howard C. Kress, and Nurul Alam

    PNAS May 14, 2013 110 (20) 8045-8050; https://doi.org/10.1073/pnas.1217029110

• Applied Biological Sciences

  • You have access

    Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics

    Guizhi Zhu, Jing Zheng, Erqun Song, Michael Donovan, Kejing Zhang, Chen Liu, and Weihong Tan

    PNAS May 14, 2013 110 (20) 7998-8003; https://doi.org/10.1073/pnas.1220817110

• Biochemistry

  • Open Access

    Single-molecule DNA repair in live bacteria

    Stephan Uphoff, Rodrigo Reyes-Lamothe, Federico Garza de Leon, David J. Sherratt, and Achillefs N. Kapanidis

    PNAS May 14, 2013 110 (20) 8063-8068; https://doi.org/10.1073/pnas.1301804110
  • You have access

    A new member of the 4-methylideneimidazole-5-one–containing aminomutase family from the enediyne kedarcidin biosynthetic pathway

    Sheng-Xiong Huang, Jeremy R. Lohman, Tingting Huang, and Ben Shen

    PNAS May 14, 2013 110 (20) 8069-8074; https://doi.org/10.1073/pnas.1304733110
  • You have access

    Structures of the phage Sf6 large terminase provide new insights into DNA translocation and cleavage

    Haiyan Zhao, Theodore E. Christensen, Yvonne N. Kamau, and Liang Tang

    PNAS May 14, 2013 110 (20) 8075-8080; https://doi.org/10.1073/pnas.1301133110
  • You have access

    Structure–kinetic relationship study of CDK8/CycC specific compounds

    Elisabeth V. Schneider, Jark Böttcher, Robert Huber, Klaus Maskos, and Lars Neumann

    PNAS May 14, 2013 110 (20) 8081-8086; https://doi.org/10.1073/pnas.1305378110

• Biophysics and Computational Biology

  • You have access

    Misplaced helix slows down ultrafast pressure-jump protein folding

    Maxim B. Prigozhin, Yanxin Liu, Anna Jean Wirth, Shobhna Kapoor, Roland Winter, Klaus Schulten, and Martin Gruebele

    PNAS May 14, 2013 110 (20) 8087-8092; https://doi.org/10.1073/pnas.1219163110
  • You have access

    Quantification of cellular penetrative forces using lab-on-a-chip technology and finite element modeling

    Amir Sanati Nezhad, Mahsa Naghavi, Muthukumaran Packirisamy, Rama Bhat, and Anja Geitmann

    PNAS May 14, 2013 110 (20) 8093-8098; https://doi.org/10.1073/pnas.1221677110

• Cell Biology

  • Open Access

    Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis

    Anni I. Nieminen, Vilja M. Eskelinen, Heidi M. Haikala, Topi A. Tervonen, Yan Yan, Johanna I. Partanen, and Juha Klefström

    PNAS May 14, 2013 110 (20) E1839-E1848; https://doi.org/10.1073/pnas.1208530110
  • You have access

    Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells

    Jia Xie, Hongkai Zhang, Kyungmoo Yea, and Richard A. Lerner

    PNAS May 14, 2013 110 (20) 8099-8104; https://doi.org/10.1073/pnas.1306263110

• Developmental Biology

  • Open Access

    p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia

    Jean-Christophe Pignon, Chiara Grisanzio, Yan Geng, Jiaxi Song, Ramesh A. Shivdasani, and Sabina Signoretti

    PNAS May 14, 2013 110 (20) 8105-8110; https://doi.org/10.1073/pnas.1221216110
  • You have access

    Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa

    Yoshitaka Fujihara, Keizo Tokuhiro, Yuko Muro, Gen Kondoh, Yoshihiko Araki, Masahito Ikawa, and Masaru Okabe

    PNAS May 14, 2013 110 (20) 8111-8116; https://doi.org/10.1073/pnas.1222166110

• Ecology

  • You have access

    Warming-induced upslope advance of subalpine forest is severely limited by geomorphic processes

    • From the Cover

    Marc Macias-Fauria and Edward A. Johnson

    PNAS May 14, 2013 110 (20) 8117-8122; https://doi.org/10.1073/pnas.1221278110

    See companion article:

    • Climate change and shifts in mountain treelines

      - Apr 30, 2013

• Evolution

  • Open Access

    Escalation of polymerization in a thermal gradient

    Christof B. Mast, Severin Schink, Ulrich Gerland, and Dieter Braun

    PNAS May 14, 2013 110 (20) 8030-8035; https://doi.org/10.1073/pnas.1303222110
  • You have access

    Diversity, host switching and evolution of Plasmodium vivax infecting African great apes

    Franck Prugnolle, Virginie Rougeron, Pierre Becquart, Antoine Berry, Boris Makanga, Nil Rahola, Céline Arnathau, Barthélémy Ngoubangoye, Sandie Menard, Eric Willaume, Francisco J. Ayala, Didier Fontenille, Benjamin Ollomo, Patrick Durand, Christophe Paupy, and François Renaud

    PNAS May 14, 2013 110 (20) 8123-8128; https://doi.org/10.1073/pnas.1306004110
  • You have access

    Provincialization of terrestrial faunas following the end-Permian mass extinction

    Christian A. Sidor, Daril A. Vilhena, Kenneth D. Angielczyk, Adam K. Huttenlocker, Sterling J. Nesbitt, Brandon R. Peecook, J. Sébastien Steyer, Roger M. H. Smith, and Linda A. Tsuji

    PNAS May 14, 2013 110 (20) 8129-8133; https://doi.org/10.1073/pnas.1302323110

• Genetics

  • You have access

    Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease

    Yohei Kirino, Qing Zhou, Yoshiaki Ishigatsubo, Nobuhisa Mizuki, Ilknur Tugal-Tutkun, Emire Seyahi, Yilmaz Özyazgan, Serdal Ugurlu, Burak Erer, Neslihan Abaci, Duran Ustek, Akira Meguro, Atsuhisa Ueda, Mitsuhiro Takeno, Hidetoshi Inoko, Michael J. Ombrello, Colleen L. Satorius, Baishali Maskeri, James C. Mullikin, Hong-Wei Sun, Gustavo Gutierrez-Cruz, Yoonhee Kim, Alexander F. Wilson, Daniel L. Kastner, Ahmet Gül, and Elaine F. Remmers

    PNAS May 14, 2013 110 (20) 8134-8139; https://doi.org/10.1073/pnas.1306352110
  • You have access

    Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis

    Francesco Acquati, Marta Lualdi, Sabrina Bertilaccio, Laura Monti, Giovanna Turconi, Marco Fabbri, Annalisa Grimaldi, Achille Anselmo, Antonio Inforzato, Angelo Collotta, Laura Cimetti, Cristina Riva, Laura Gribaldo, Paolo Ghia, and Roberto Taramelli

    PNAS May 14, 2013 110 (20) 8140-8145; https://doi.org/10.1073/pnas.1222079110

• Immunology

  • You have access

    Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and Protein kinase B AKT signaling

    Liying Guo, Craig Martens, Daniel Bruno, Stephen F. Porcella, Hidehiro Yamane, Stephane M. Caucheteux, Jinfang Zhu, and William E. Paul

    PNAS May 14, 2013 110 (20) E1849-E1856; https://doi.org/10.1073/pnas.1305070110
  • You have access

    Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η

    Ye Zhao, Mark T. Gregory, Christian Biertümpfel, Yue-Jin Hua, Fumio Hanaoka, and Wei Yang

    PNAS May 14, 2013 110 (20) 8146-8151; https://doi.org/10.1073/pnas.1303126110
  • You have access

    Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8⁺ T cell skewing in allergic lung disease

    Yi Jia, Joanne Domenico, Katsuyuki Takeda, Junyan Han, Meiqin Wang, Michael Armstrong, Nichole Reisdorph, Brian P. O’Connor, Joseph J. Lucas, and Erwin W. Gelfand

    PNAS May 14, 2013 110 (20) 8152-8157; https://doi.org/10.1073/pnas.1216671110
  • You have access

    IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner

    Rebecca Berlant Liu, Boris Engels, Karin Schreiber, Cezary Ciszewski, Andrea Schietinger, Hans Schreiber, and Bana Jabri

    PNAS May 14, 2013 110 (20) 8158-8163; https://doi.org/10.1073/pnas.1301022110
  • You have access

    Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases

    John S. Barber, Lauren K. Yokomizo, Virginia Sheikh, Alexandra F. Freeman, Elizabeth Garabedian, Evert van Dijk, Robert Sokolic, Fabio Candotti, Nan-ping Weng, Irini Sereti, and Joshua D. Milner

    PNAS May 14, 2013 110 (20) 8164-8169; https://doi.org/10.1073/pnas.1302103110

• Medical Sciences

  • Open Access

    Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist

    Lyudmila G. Burdelya, Craig M. Brackett, Bojidar Kojouharov, Ilya I. Gitlin, Katerina I. Leonova, Anatoli S. Gleiberman, Semra Aygun-Sunar, Jean Veith, Christopher Johnson, Gary J. Haderski, Patricia Stanhope-Baker, Shyam Allamaneni, Joseph Skitzki, Ming Zeng, Elena Martsen, Alexander Medvedev, Dmitry Scheblyakov, Nataliya M. Artemicheva, Denis Y. Logunov, Alexander L. Gintsburg, Boris S. Naroditsky, Sergei S. Makarov, and Andrei V. Gudkov

    PNAS May 14, 2013 110 (20) E1857-E1866; https://doi.org/10.1073/pnas.1222805110
  • You have access

    Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth

    Georg Mahlknecht, Ruth Maron, Maicol Mancini, Bilha Schechter, Michael Sela, and Yosef Yarden

    PNAS May 14, 2013 110 (20) 8170-8175; https://doi.org/10.1073/pnas.1302594110
  • You have access

    Latency of Epstein–Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA

    Kuan-Ping Yu, Lee Heston, Richard Park, Zhaowei Ding, Ruth Wang’ondu, Henri-Jacques Delecluse, and George Miller

    PNAS May 14, 2013 110 (20) 8176-8181; https://doi.org/10.1073/pnas.1301577110
  • You have access

    In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction

    Fumi Shima, Yoko Yoshikawa, Min Ye, Mitsugu Araki, Shigeyuki Matsumoto, Jingling Liao, Lizhi Hu, Takeshi Sugimoto, Yuichi Ijiri, Azusa Takeda, Yuko Nishiyama, Chie Sato, Shin Muraoka, Atsuo Tamura, Tsutomu Osoda, Ken-ichiro Tsuda, Tomoya Miyakawa, Hiroaki Fukunishi, Jiro Shimada, Takashi Kumasaka, Masaki Yamamoto, and Tohru Kataoka

    PNAS May 14, 2013 110 (20) 8182-8187; https://doi.org/10.1073/pnas.1217730110
  • Open Access

    Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

    Lori A. Ramkissoon, Peleg M. Horowitz, Justin M. Craig, Shakti H. Ramkissoon, Benjamin E. Rich, Steven E. Schumacher, Aaron McKenna, Michael S. Lawrence, Guillaume Bergthold, Priscilla K. Brastianos, Barbara Tabak, Matthew D. Ducar, Paul Van Hummelen, Laura E. MacConaill, Tina Pouissant-Young, Yoon-Jae Cho, Hala Taha, Madeha Mahmoud, Daniel C. Bowers, Linda Margraf, Uri Tabori, Cynthia Hawkins, Roger J. Packer, D. Ashley Hill, Scott L. Pomeroy, Charles G. Eberhart, Ian F. Dunn, Liliana Goumnerova, Gad Getz, Jennifer A. Chan, Sandro Santagata, William C. Hahn, Charles D. Stiles, Azra H. Ligon, Mark W. Kieran, Rameen Beroukhim, and Keith L. Ligon

    PNAS May 14, 2013 110 (20) 8188-8193; https://doi.org/10.1073/pnas.1300252110

• Microbiology

  • You have access

    Engineering recombinant reoviruses with tandem repeats and a tetravirus 2A-like element for exogenous polypeptide expression

    Aleksander A. Demidenko, Joseph N. Blattman, Negin N. Blattman, Philip D. Greenberg, and Max L. Nibert

    PNAS May 14, 2013 110 (20) E1867-E1876; https://doi.org/10.1073/pnas.1220107110
  • You have access

    Bats are a major natural reservoir for hepaciviruses and pegiviruses

    Phenix-Lan Quan, Cadhla Firth, Juliette M. Conte, Simon H. Williams, Carlos M. Zambrana-Torrelio, Simon J. Anthony, James A. Ellison, Amy T. Gilbert, Ivan V. Kuzmin, Michael Niezgoda, Modupe O. V. Osinubi, Sergio Recuenco, Wanda Markotter, Robert F. Breiman, Lems Kalemba, Jean Malekani, Kim A. Lindblade, Melinda K. Rostal, Rafael Ojeda-Flores, Gerardo Suzan, Lora B. Davis, Dianna M. Blau, Albert B. Ogunkoya, Danilo A. Alvarez Castillo, David Moran, Sali Ngam, Dudu Akaibe, Bernard Agwanda, Thomas Briese, Jonathan H. Epstein, Peter Daszak, Charles E. Rupprecht, Edward C. Holmes, and W. Ian Lipkin

    PNAS May 14, 2013 110 (20) 8194-8199; https://doi.org/10.1073/pnas.1303037110
  • You have access

    miRNA regulation of BK polyomavirus replication during early infection

    Nicole M. Broekema and Michael J. Imperiale

    PNAS May 14, 2013 110 (20) 8200-8205; https://doi.org/10.1073/pnas.1301907110
  • You have access

    Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus

    Laura A. Mike, Brendan F. Dutter, Devin L. Stauff, Jessica L. Moore, Nicholas P. Vitko, Olusegun Aranmolate, Thomas E. Kehl-Fie, Sarah Sullivan, Paul R. Reid, Jennifer L. DuBois, Anthony R. Richardson, Richard M. Caprioli, Gary A. Sulikowski, and Eric P. Skaar

    PNAS May 14, 2013 110 (20) 8206-8211; https://doi.org/10.1073/pnas.1303674110
  • You have access

    Surface display of a massively variable lipoprotein by a Legionella diversity-generating retroelement

    Diego Arambula, Wenge Wong, Bob A. Medhekar, Huatao Guo, Mari Gingery, Elizabeth Czornyj, Minghsun Liu, Sanghamitra Dey, Partho Ghosh, and Jeff F. Miller

    PNAS May 14, 2013 110 (20) 8212-8217; https://doi.org/10.1073/pnas.1301366110

• Neuroscience

  • You have access

    AMPA receptor exchange underlies transient memory destabilization on retrieval

    Ingie Hong, Jeongyeon Kim, Jihye Kim, Sukwon Lee, Hyoung-Gon Ko, Karim Nader, Bong-Kiun Kaang, Richard W. Tsien, and Sukwoo Choi

    PNAS May 14, 2013 110 (20) 8218-8223; https://doi.org/10.1073/pnas.1305235110
  • Open Access

    Conserved MIP receptor–ligand pair regulates Platynereis larval settlement

    • From the Cover

    Markus Conzelmann, Elizabeth A. Williams, Sorin Tunaru, Nadine Randel, Réza Shahidi, Albina Asadulina, Jürgen Berger, Stefan Offermanns, and Gáspár Jékely

    PNAS May 14, 2013 110 (20) 8224-8229; https://doi.org/10.1073/pnas.1220285110

    See companion article:

    • Neuropeptides control life-phase transitions

      - Apr 23, 2013
  • You have access

    Neural predictors of individual differences in response to math tutoring in primary-grade school children

    Kaustubh Supekar, Anna G. Swigart, Caitlin Tenison, Dietsje D. Jolles, Miriam Rosenberg-Lee, Lynn Fuchs, and Vinod Menon

    PNAS May 14, 2013 110 (20) 8230-8235; https://doi.org/10.1073/pnas.1222154110
  • You have access

    Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling

    Xi Lin, Baohui Liu, Xiangsheng Yang, Xiaojing Yue, Lixia Diao, Jing Wang, and Jiang Chang

    PNAS May 14, 2013 110 (20) 8236-8241; https://doi.org/10.1073/pnas.1219995110
  • Open Access

    Synaptopodin regulates denervation-induced homeostatic synaptic plasticity

    Andreas Vlachos, Benno Ikenberg, Maximilian Lenz, Denise Becker, Kurt Reifenberg, Carlos Bas-Orth, and Thomas Deller

    PNAS May 14, 2013 110 (20) 8242-8247; https://doi.org/10.1073/pnas.1213677110
  • You have access

    Intermediate intrinsic diversity enhances neural population coding

    Shreejoy J. Tripathy, Krishnan Padmanabhan, Richard C. Gerkin, and Nathaniel N. Urban

    PNAS May 14, 2013 110 (20) 8248-8253; https://doi.org/10.1073/pnas.1221214110
  • You have access

    Regulator of G protein signaling 4 is a crucial modulator of antidepressant drug action in depression and neuropathic pain models

    Maria Stratinaki, Artemis Varidaki, Vasiliki Mitsi, Subroto Ghose, Jane Magida, Caroline Dias, Scott J. Russo, Vincent Vialou, Barbara J. Caldarone, Carol A. Tamminga, Eric J. Nestler, and Venetia Zachariou

    PNAS May 14, 2013 110 (20) 8254-8259; https://doi.org/10.1073/pnas.1214696110
  • You have access

    Blood meal-induced changes to antennal transcriptome profiles reveal shifts in odor sensitivities in Anopheles gambiae

    • From the Cover

    David C. Rinker, R. Jason Pitts, Xiaofan Zhou, Eunho Suh, Antonis Rokas, and Laurence J. Zwiebel

    PNAS May 14, 2013 110 (20) 8260-8265; https://doi.org/10.1073/pnas.1302562110
  • You have access

    Fast neurotransmitter release regulated by the endocytic scaffold intersectin

    Takeshi Sakaba, Natalia L. Kononenko, Jelena Bacetic, Arndt Pechstein, Jan Schmoranzer, Lijun Yao, Holger Barth, Oleg Shupliakov, Oliver Kobler, Klaus Aktories, and Volker Haucke

    PNAS May 14, 2013 110 (20) 8266-8271; https://doi.org/10.1073/pnas.1219234110

• Physiology

  • You have access

    Dynamics of internal pore opening in K_V channels probed by a fluorescent unnatural amino acid

    Tanja Kalstrup and Rikard Blunck

    PNAS May 14, 2013 110 (20) 8272-8277; https://doi.org/10.1073/pnas.1220398110
  • You have access

    Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

    Myriam Aouadi, Michaela Tencerova, Pranitha Vangala, Joseph C. Yawe, Sarah M. Nicoloro, Shinya U. Amano, Jessica L. Cohen, and Michael P. Czech

    PNAS May 14, 2013 110 (20) 8278-8283; https://doi.org/10.1073/pnas.1300492110

• Plant Biology

  • Open Access

    Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis

    Yongxia Guo, Zuyu Zheng, James J. La Clair, Joanne Chory, and Joseph P. Noel

    PNAS May 14, 2013 110 (20) 8284-8289; https://doi.org/10.1073/pnas.1306265110
  • You have access

    DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV

    Heng Zhang, Ze-Yang Ma, Liang Zeng, Kaori Tanaka, Cui-Jun Zhang, Jun Ma, Ge Bai, Pengcheng Wang, Su-Wei Zhang, Zhang-Wei Liu, Tao Cai, Kai Tang, Renyi Liu, Xiaobing Shi, Xin-Jian He, and Jian-Kang Zhu

    PNAS May 14, 2013 110 (20) 8290-8295; https://doi.org/10.1073/pnas.1300585110
  • You have access

    Arabidopsis nanodomain-delimited ABA signaling pathway regulates the anion channel SLAH3

    Fatih Demir, Claudia Horntrich, Jörg O. Blachutzik, Sönke Scherzer, Yvonne Reinders, Sylwia Kierszniowska, Waltraud X. Schulze, Gregory S. Harms, Rainer Hedrich, Dietmar Geiger, and Ines Kreuzer

    PNAS May 14, 2013 110 (20) 8296-8301; https://doi.org/10.1073/pnas.1211667110

• Psychological and Cognitive Sciences

  • You have access

    Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder

    Divya Mehta, Torsten Klengel, Karen N. Conneely, Alicia K. Smith, André Altmann, Thaddeus W. Pace, Monika Rex-Haffner, Anne Loeschner, Mariya Gonik, Kristina B. Mercer, Bekh Bradley, Bertram Müller-Myhsok, Kerry J. Ressler, and Elisabeth B. Binder

    PNAS May 14, 2013 110 (20) 8302-8307; https://doi.org/10.1073/pnas.1217750110
  • You have access

    Subjective costs drive overly patient foraging strategies in rats on an intertemporal foraging task

    Andrew M. Wikenheiser, David W. Stephens, and A. David Redish

    PNAS May 14, 2013 110 (20) 8308-8313; https://doi.org/10.1073/pnas.1220738110