Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Miniature curved artificial compound eyes

    Dario Floreano, Ramon Pericet-Camara, Stéphane Viollet, Franck Ruffier, Andreas Brückner, Robert Leitel, Wolfgang Buss, Mohsine Menouni, Fabien Expert, Raphaël Juston, Michal Karol Dobrzynski, Geraud L’Eplattenier, Fabian Recktenwald, Hanspeter A. Mallot, and Nicolas Franceschini

    PNAS June 4, 2013 110 (23) 9267-9272; https://doi.org/10.1073/pnas.1219068110

• Biochemistry

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    Sustained accurate recording of intracellular acidification in living tissues with a photo-controllable bioluminescent protein

    Mitsuru Hattori, Sanae Haga, Hideo Takakura, Michitaka Ozaki, and Takeaki Ozawa

    PNAS June 4, 2013 110 (23) 9332-9337; https://doi.org/10.1073/pnas.1304056110
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    In vitro reconstitution of lipid-dependent dual topology and postassembly topological switching of a membrane protein

    Heidi Vitrac, Mikhail Bogdanov, and William Dowhan

    PNAS June 4, 2013 110 (23) 9338-9343; https://doi.org/10.1073/pnas.1304375110

• Biophysics and Computational Biology

  • Open Access

    Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

    Oliver J. Britton, Alfonso Bueno-Orovio, Karel Van Ammel, Hua Rong Lu, Rob Towart, David J. Gallacher, and Blanca Rodriguez

    PNAS June 4, 2013 110 (23) E2098-E2105; https://doi.org/10.1073/pnas.1304382110
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    Interplay of physics and evolution in the likely origin of protein biochemical function

    Jeffrey Skolnick and Mu Gao

    PNAS June 4, 2013 110 (23) 9344-9349; https://doi.org/10.1073/pnas.1300011110
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    Multispot, label-free biodetection at a phantom plastic–water interface

    Fabio Giavazzi, Matteo Salina, Roberto Cerbino, Mattia Bassi, Davide Prosperi, Erica Ceccarello, Francesco Damin, Laura Sola, Marco Rusnati, Marcella Chiari, Bice Chini, Tommaso Bellini, and Marco Buscaglia

    PNAS June 4, 2013 110 (23) 9350-9355; https://doi.org/10.1073/pnas.1214589110

• Cell Biology

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    Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

    Maksim V. Plikus, Christopher Vollmers, Damon de la Cruz, Amandine Chaix, Raul Ramos, Satchidananda Panda, and Cheng-Ming Chuong

    PNAS June 4, 2013 110 (23) E2106-E2115; https://doi.org/10.1073/pnas.1215935110
  • Open Access

    Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium

    Xia Gao, Christopher M. Vockley, Florencia Pauli, Kimberly M. Newberry, Yan Xue, Scott H. Randell, Timothy E. Reddy, and Brigid L. M. Hogan

    PNAS June 4, 2013 110 (23) 9356-9361; first published May 20, 2013. https://doi.org/10.1073/pnas.1307589110
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    Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality

    Seong-Jun Cho, Andrea Rossi, Yong-Sam Jung, Wensheng Yan, Gang Liu, Jin Zhang, Min Zhang, and Xinbin Chen

    PNAS June 4, 2013 110 (23) 9362-9367; https://doi.org/10.1073/pnas.1221242110

• Developmental Biology

  • Open Access

    Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells

    • From the Cover

    Noa Sher, Jessica R. Von Stetina, George W. Bell, Shinobu Matsuura, Katya Ravid, and Terry L. Orr-Weaver

    PNAS June 4, 2013 110 (23) 9368-9373; https://doi.org/10.1073/pnas.1304889110

    See companion article:

    • Making big cells: One size does not fit all

      - Jun 11, 2013

• Ecology

  • Open Access

    Space can substitute for time in predicting climate-change effects on biodiversity

    Jessica L. Blois, John W. Williams, Matthew C. Fitzpatrick, Stephen T. Jackson, and Simon Ferrier

    PNAS June 4, 2013 110 (23) 9374-9379; https://doi.org/10.1073/pnas.1220228110

• Evolution

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    High flight costs, but low dive costs, in auks support the biomechanical hypothesis for flightlessness in penguins

    Kyle H. Elliott, Robert E. Ricklefs, Anthony J. Gaston, Scott A. Hatch, John R. Speakman, and Gail K. Davoren

    PNAS June 4, 2013 110 (23) 9380-9384; https://doi.org/10.1073/pnas.1304838110
  • Open Access

    Complex history of the amphibian-killing chytrid fungus revealed with genome resequencing data

    • From the Cover

    Erica Bree Rosenblum, Timothy Y. James, Kelly R. Zamudio, Thomas J. Poorten, Dan Ilut, David Rodriguez, Jonathan M. Eastman, Katy Richards-Hrdlicka, Suzanne Joneson, Thomas S. Jenkinson, Joyce E. Longcore, Gabriela Parra Olea, Luís Felipe Toledo, Maria Luz Arellano, Edgar M. Medina, Silvia Restrepo, Sandra Victoria Flechas, Lee Berger, Cheryl J. Briggs, and Jason E. Stajich

    PNAS June 4, 2013 110 (23) 9385-9390; https://doi.org/10.1073/pnas.1300130110

    See companion article:

    • History, novelty, and emergence of an infectious amphibian disease

      - Jun 04, 2013
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    Founder effects initiated rapid species radiation in Hawaiian cave planthoppers

    Andreas Wessel, Hannelore Hoch, Manfred Asche, Thomas von Rintelen, Björn Stelbrink, Volker Heck, Fred D. Stone, and Francis G. Howarth

    PNAS June 4, 2013 110 (23) 9391-9396; https://doi.org/10.1073/pnas.1301657110

• Genetics

  • Open Access

    Country-level operational implementation of the Global Plan for Insecticide Resistance Management

    Janet Hemingway, John Vontas, Rodolphe Poupardin, Jaishree Raman, Jo Lines, Chris Schwabe, Abrahan Matias, and Immo Kleinschmidt

    PNAS June 4, 2013 110 (23) 9397-9402; https://doi.org/10.1073/pnas.1307656110
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    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Mark Drost, Anne Lützen, Sandrine van Hees, Daniel Ferreira, Fabienne Calléja, José B. M. Zonneveld, Finn Cilius Nielsen, Lene Juel Rasmussen, and Niels de Wind

    PNAS June 4, 2013 110 (23) 9403-9408; https://doi.org/10.1073/pnas.1220537110

• Immunology

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    Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression

    Tomoyuki Yamaguchi, Ayumi Kishi, Motonao Osaki, Hiromasa Morikawa, Paz Prieto-Martin, Kajsa Wing, Takashi Saito, and Shimon Sakaguchi

    PNAS June 4, 2013 110 (23) E2116-E2125; https://doi.org/10.1073/pnas.1307185110
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    Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

    Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, and Tadamitsu Kishimoto

    PNAS June 4, 2013 110 (23) 9409-9414; https://doi.org/10.1073/pnas.1307419110
  • Open Access

    Macrophages are required for adult salamander limb regeneration

    James W. Godwin, Alexander R. Pinto, and Nadia A. Rosenthal

    PNAS June 4, 2013 110 (23) 9415-9420; https://doi.org/10.1073/pnas.1300290110
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    Fratricide of natural killer cells dressed with tumor-derived NKG2D ligand

    Kyohei Nakamura, Masafumi Nakayama, Mitsuko Kawano, Ryo Amagai, Tomonori Ishii, Hideo Harigae, and Kouetsu Ogasawara

    PNAS June 4, 2013 110 (23) 9421-9426; https://doi.org/10.1073/pnas.1300140110
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    Parasitoid wasp venom SERCA regulates Drosophila calcium levels and inhibits cellular immunity

    Nathan T. Mortimer, Jeremy Goecks, Balint Z. Kacsoh, James A. Mobley, Gregory J. Bowersock, James Taylor, and Todd A. Schlenke

    PNAS June 4, 2013 110 (23) 9427-9432; https://doi.org/10.1073/pnas.1222351110
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    Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex

    Yoon Park, Hyung-seung Jin, and Yun-Cai Liu

    PNAS June 4, 2013 110 (23) 9433-9438; https://doi.org/10.1073/pnas.1221925110
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    The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization

    Mike C. L. Wu, Faith H. Brennan, Jason P. L. Lynch, Susanna Mantovani, Simon Phipps, Rick A. Wetsel, Marc J. Ruitenberg, Stephen M. Taylor, and Trent M. Woodruff

    PNAS June 4, 2013 110 (23) 9439-9444; https://doi.org/10.1073/pnas.1218815110

• Medical Sciences

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    Biodegradable synthetic high-density lipoprotein nanoparticles for atherosclerosis

    Sean Marrache and Shanta Dhar

    PNAS June 4, 2013 110 (23) 9445-9450; https://doi.org/10.1073/pnas.1301929110

    See companion article:

    • Reply to Cormode et al.: High-density lipoprotein mimicking synthetic nanoparticle

      - Sep 17, 2013
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    Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling

    Ibrahim Yazji, Chhinder P. Sodhi, Elizabeth K. Lee, Misty Good, Charlotte E. Egan, Amin Afrazi, Matthew D. Neal, Hongpeng Jia, Joyce Lin, Congrong Ma, Maria F. Branca, Thomas Prindle, Ward M. Richardson, John Ozolek, Timothy R. Billiar, David G. Binion, Mark T. Gladwin, and David J. Hackam

    PNAS June 4, 2013 110 (23) 9451-9456; https://doi.org/10.1073/pnas.1219997110
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    Identifying dynamic tuberculosis case-finding policies for HIV/TB coepidemics

    Reza Yaesoubi and Ted Cohen

    PNAS June 4, 2013 110 (23) 9457-9462; https://doi.org/10.1073/pnas.1218770110
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    Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina

    Hormoz Moaven, Yukihiro Koike, Christine C. Jao, Vsevolod V. Gurevich, Ralf Langen, and Jeannie Chen

    PNAS June 4, 2013 110 (23) 9463-9468; https://doi.org/10.1073/pnas.1301126110
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    NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation

    Jia Chang, Fei Liu, Min Lee, Benjamin Wu, Kang Ting, Janette N. Zara, Chia Soo, Khalid Al Hezaimi, Weiping Zou, Xiaohong Chen, David J. Mooney, and Cun-Yu Wang

    PNAS June 4, 2013 110 (23) 9469-9474; https://doi.org/10.1073/pnas.1300532110
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    HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines

    Philippe Colin, Yann Bénureau, Isabelle Staropoli, Yongjin Wang, Nuria Gonzalez, Jose Alcami, Oliver Hartley, Anne Brelot, Fernando Arenzana-Seisdedos, and Bernard Lagane

    PNAS June 4, 2013 110 (23) 9475-9480; https://doi.org/10.1073/pnas.1222205110

• Microbiology

  • Open Access

    Dietary choice affects Shiga toxin-producing Escherichia coli (STEC) O157:H7 colonization and disease

    Steven D. Zumbrun, Angela R. Melton-Celsa, Mark A. Smith, Jeremy J. Gilbreath, D. Scott Merrell, and Alison D. O’Brien

    PNAS June 4, 2013 110 (23) E2126-E2133; https://doi.org/10.1073/pnas.1222014110
  • Open Access

    Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice

    Chen Yang, Steven Skiena, Bruce Futcher, Steffen Mueller, and Eckard Wimmer

    PNAS June 4, 2013 110 (23) 9481-9486; https://doi.org/10.1073/pnas.1307473110
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    Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag

    William M. Schneider, Jonathon D. Brzezinski, Sriram Aiyer, Nirav Malani, Mercedes Gyuricza, Frederic D. Bushman, and Monica J. Roth

    PNAS June 4, 2013 110 (23) 9487-9492; https://doi.org/10.1073/pnas.1221736110

    See companion article:

    • Murine leukemia virus p12 functions include hitchhiking into the nucleus

      - Jun 04, 2013
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    Methionine oxidation activates a transcription factor in response to oxidative stress

    Adrian Drazic, Haruko Miura, Jirka Peschek, Yan Le, Nina C. Bach, Thomas Kriehuber, and Jeannette Winter

    PNAS June 4, 2013 110 (23) 9493-9498; https://doi.org/10.1073/pnas.1300578110
  • Open Access

    The lipopolysaccharide modification regulator PmrA limits Salmonella virulence by repressing the type three-secretion system Spi/Ssa

    Jeongjoon Choi and Eduardo A. Groisman

    PNAS June 4, 2013 110 (23) 9499-9504; https://doi.org/10.1073/pnas.1303420110
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    Ultrastructural analysis of hepatitis C virus particles

    Maria Teresa Catanese, Kunihiro Uryu, Martina Kopp, Thomas J. Edwards, Linda Andrus, William J. Rice, Mariena Silvestry, Richard J. Kuhn, and Charles M. Rice

    PNAS June 4, 2013 110 (23) 9505-9510; https://doi.org/10.1073/pnas.1307527110

• Neuroscience

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    Functional diversity among sensory receptors in a Drosophila olfactory circuit

    Dennis Mathew, Carlotta Martelli, Elizabeth Kelley-Swift, Christopher Brusalis, Marc Gershow, Aravinthan D. T. Samuel, Thierry Emonet, and John R. Carlson

    PNAS June 4, 2013 110 (23) E2134-E2143; https://doi.org/10.1073/pnas.1306976110
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    Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons

    Emmanuelle Jordi, Myriam Heiman, Lucile Marion-Poll, Pierre Guermonprez, Shuk Kei Cheng, Angus C. Nairn, Paul Greengard, and Jean-Antoine Girault

    PNAS June 4, 2013 110 (23) 9511-9516; https://doi.org/10.1073/pnas.1307116110
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    Spatiotemporal dynamics of neuronal population response in the primary visual cortex

    Douglas Zhou, Aaditya V. Rangan, David W. McLaughlin, and David Cai

    PNAS June 4, 2013 110 (23) 9517-9522; https://doi.org/10.1073/pnas.1308167110
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    Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment

    Gwenaëlle Douaud, Helga Refsum, Celeste A. de Jager, Robin Jacoby, Thomas E. Nichols, Stephen M. Smith, and A. David Smith

    PNAS June 4, 2013 110 (23) 9523-9528; https://doi.org/10.1073/pnas.1301816110
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    GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

    Rebecca C. Meyer, Michelle M. Giddens, Stacy A. Schaefer, and Randy A. Hall

    PNAS June 4, 2013 110 (23) 9529-9534; https://doi.org/10.1073/pnas.1219004110
  • Open Access

    Brain homogenates from human tauopathies induce tau inclusions in mouse brain

    Florence Clavaguera, Hiroyasu Akatsu, Graham Fraser, R. Anthony Crowther, Stephan Frank, Jürgen Hench, Alphonse Probst, David T. Winkler, Julia Reichwald, Matthias Staufenbiel, Bernardino Ghetti, Michel Goedert, and Markus Tolnay

    PNAS June 4, 2013 110 (23) 9535-9540; https://doi.org/10.1073/pnas.1301175110
  • Open Access

    Development of cortical microstructure in the preterm human brain

    Gareth Ball, Latha Srinivasan, Paul Aljabar, Serena J. Counsell, Giuliana Durighel, Joseph V. Hajnal, Mary A. Rutherford, and A. David Edwards

    PNAS June 4, 2013 110 (23) 9541-9546; https://doi.org/10.1073/pnas.1301652110
  • Open Access

    Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse

    Elizabeth S. Maywood, Lesley Drynan, Johanna E. Chesham, Mathew D. Edwards, Hugues Dardente, Jean-Michel Fustin, David G. Hazlerigg, John S. O’Neill, Gemma F. Codner, Nicola J. Smyllie, Marco Brancaccio, and Michael H. Hastings

    PNAS June 4, 2013 110 (23) 9547-9552; https://doi.org/10.1073/pnas.1220894110

• Physiology

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    Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

    Anna Garcia-Elias, Sanela Mrkonjić, Carlos Pardo-Pastor, Hitoshi Inada, Ute A. Hellmich, Fanny Rubio-Moscardó, Cristina Plata, Rachelle Gaudet, Rubén Vicente, and Miguel A. Valverde

    PNAS June 4, 2013 110 (23) 9553-9558; https://doi.org/10.1073/pnas.1220231110

• Plant Biology

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    Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis

    • From the Cover

    Sang-Wook Park, Wei Li, Andrea Viehhauser, Bin He, Soonok Kim, Anders K. Nilsson, Mats X. Andersson, Joshua D. Kittle, Madana M. R. Ambavaram, Sheng Luan, Alan R. Esker, Dorothea Tholl, Daniela Cimini, Mats Ellerström, Gitta Coaker, Thomas K. Mitchell, Andy Pereira, Karl-Josef Dietz, and Christopher B. Lawrence

    PNAS June 4, 2013 110 (23) 9559-9564; https://doi.org/10.1073/pnas.1218872110

    See companion article:

    • 12-oxo-phytodienoic acid interaction with cyclophilin CYP20-3 is a benchmark for understanding retrograde signaling in plants

      - Jun 04, 2013
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    Structural insights into the N-terminal GIY–YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts

    Xi Liu, Shian Liu, Yingang Feng, Jian-Zhong Liu, Yuling Chen, Khanh Pham, Haiteng Deng, Kendal D. Hirschi, Xinquan Wang, and Ninghui Cheng

    PNAS June 4, 2013 110 (23) 9565-9570; https://doi.org/10.1073/pnas.1306899110
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    Recruitment and remodeling of an ancient gene regulatory network during land plant evolution

    Nuno D. Pires, Keke Yi, Holger Breuninger, Bruno Catarino, Benoît Menand, and Liam Dolan

    PNAS June 4, 2013 110 (23) 9571-9576; https://doi.org/10.1073/pnas.1305457110
  • Open Access

    Blast resistance of CC-NB-LRR protein Pb1 is mediated by WRKY45 through protein–protein interaction

    Haruhiko Inoue, Nagao Hayashi, Akane Matsushita, Liu Xinqiong, Akira Nakayama, Shoji Sugano, Chang-Jie Jiang, and Hiroshi Takatsuji

    PNAS June 4, 2013 110 (23) 9577-9582; https://doi.org/10.1073/pnas.1222155110
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    Single-membrane–bounded peroxisome division revealed by isolation of dynamin-based machinery

    Yuuta Imoto, Haruko Kuroiwa, Yamato Yoshida, Mio Ohnuma, Takayuki Fujiwara, Masaki Yoshida, Keiji Nishida, Fumi Yagisawa, Shunsuke Hirooka, Shin-ya Miyagishima, Osami Misumi, Shigeyuki Kawano, and Tsuneyoshi Kuroiwa

    PNAS June 4, 2013 110 (23) 9583-9588; https://doi.org/10.1073/pnas.1303483110
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    Glutathione and tryptophan metabolism are required for Arabidopsis immunity during the hypersensitive response to hemibiotrophs

    Kei Hiruma, Satoshi Fukunaga, Paweł Bednarek, Mariola Piślewska-Bednarek, Satoshi Watanabe, Yoshihiro Narusaka, Ken Shirasu, and Yoshitaka Takano

    PNAS June 4, 2013 110 (23) 9589-9594; https://doi.org/10.1073/pnas.1305745110

• Population Biology

  • Open Access

    Deciphering the impacts of vaccination and immunity on pertussis epidemiology in Thailand

    Julie C. Blackwood, Derek A. T. Cummings, Hélène Broutin, Sopon Iamsirithaworn, and Pejman Rohani

    PNAS June 4, 2013 110 (23) 9595-9600; https://doi.org/10.1073/pnas.1220908110

• Psychological and Cognitive Sciences

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    Impairing existing declarative memory in humans by disrupting reconsolidation

    Jason C. K. Chan and Jessica A. LaPaglia

    PNAS June 4, 2013 110 (23) 9309-9313; https://doi.org/10.1073/pnas.1218472110

• Sustainability Science

  • Open Access

    Dependence of hydropower energy generation on forests in the Amazon Basin at local and regional scales

    Claudia M. Stickler, Michael T. Coe, Marcos H. Costa, Daniel C. Nepstad, David G. McGrath, Livia C. P. Dias, Hermann O. Rodrigues, and Britaldo S. Soares-Filho

    PNAS June 4, 2013 110 (23) 9601-9606; https://doi.org/10.1073/pnas.1215331110

• Systems Biology

  • Open Access

    Systematic functional regulatory assessment of disease-associated variants

    Konrad J. Karczewski, Joel T. Dudley, Kimberly R. Kukurba, Rong Chen, Atul J. Butte, Stephen B. Montgomery, and Michael Snyder

    PNAS June 4, 2013 110 (23) 9607-9612; https://doi.org/10.1073/pnas.1219099110