Table of Contents

Biological Sciences

• Applied Biological Sciences

  • Open Access

    Quantitative selection and parallel characterization of aptamers

    Minseon Cho, Seung Soo Oh, Jeff Nie, Ron Stewart, Michael Eisenstein, James Chambers, Jamey D. Marth, Faye Walker, James A. Thomson, and H. Tom Soh

    PNAS November 12, 2013 110 (46) 18460-18465; https://doi.org/10.1073/pnas.1315866110
  • Open Access

    Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees

    • Cozzarelli Prize Winner

    Gennaro Di Prisco, Valeria Cavaliere, Desiderato Annoscia, Paola Varricchio, Emilio Caprio, Francesco Nazzi, Giuseppe Gargiulo, and Francesco Pennacchio

    PNAS November 12, 2013 110 (46) 18466-18471; https://doi.org/10.1073/pnas.1314923110

• Biochemistry

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    Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain

    Helena Öhrvik, Yasuhiro Nose, L. Kent Wood, Byung-Eun Kim, Sophie-Charlotte Gleber, Martina Ralle, and Dennis J. Thiele

    PNAS November 12, 2013 110 (46) E4279-E4288; https://doi.org/10.1073/pnas.1311749110
  • Open Access

    Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins

    Nikki Bowen, Catherine E. Smith, Anjana Srivatsan, Smaranda Willcox, Jack D. Griffith, and Richard D. Kolodner

    PNAS November 12, 2013 110 (46) 18472-18477; https://doi.org/10.1073/pnas.1318971110
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    Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ

    Claudine Baraquet and Caroline S. Harwood

    PNAS November 12, 2013 110 (46) 18478-18483; https://doi.org/10.1073/pnas.1318972110
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    Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter

    John Edward Pak, Elisabeth Ngonlong Ekendé, Efrem G. Kifle, Joseph Daniel O’Connell III, Fabien De Angelis, Meseret B. Tessema, Kheiro-Mouna Derfoufi, Yaneth Robles-Colmenares, Rebecca A. Robbins, Erik Goormaghtigh, Guy Vandenbussche, and Robert M. Stroud

    PNAS November 12, 2013 110 (46) 18484-18489; https://doi.org/10.1073/pnas.1318705110
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    Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

    • From the Cover

    Carsten C. Scholz, Miguel A. S. Cavadas, Murtaza M. Tambuwala, Emily Hams, Javier Rodríguez, Alex von Kriegsheim, Philip Cotter, Ulrike Bruning, Padraic G. Fallon, Alex Cheong, Eoin P. Cummins, and Cormac T. Taylor

    PNAS November 12, 2013 110 (46) 18490-18495; https://doi.org/10.1073/pnas.1309718110

    See companion article:

    • Hypoxia and inflammation are two sides of the same coin

      - Nov 12, 2013
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    Hemoglobin-derived porphyrins preserved in a Middle Eocene blood-engorged mosquito

    • From the Cover

    Dale E. Greenwalt, Yulia S. Goreva, Sandra M. Siljeström, Tim Rose, and Ralph E. Harbach

    PNAS November 12, 2013 110 (46) 18496-18500; https://doi.org/10.1073/pnas.1310885110

    See companion article:

    • A mosquito’s last supper reminds us not to underestimate the fossil record

      - Nov 12, 2013
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    Cytosolic reducing power preserves glutamate in retina

    Jianhai Du, Whitney Cleghorn, Laura Contreras, Jonathan D. Linton, Guy C.-K. Chan, Andrei O. Chertov, Takeyori Saheki, Viren Govindaraju, Martin Sadilek, Jorgina Satrústegui, and James B. Hurley

    PNAS November 12, 2013 110 (46) 18501-18506; https://doi.org/10.1073/pnas.1311193110

• Biophysics and Computational Biology

  • Open Access

    Substrate protein switches GroE chaperonins from asymmetric to symmetric cycling by catalyzing nucleotide exchange

    Xiang Ye and George H. Lorimer

    PNAS November 12, 2013 110 (46) E4289-E4297; https://doi.org/10.1073/pnas.1317702110

    See companion article:

    • Symmetric GroEL:GroES₂ complexes are the protein-folding functional form of the chaperonin nanomachine

      - Nov 12, 2013
  • Open Access

    Symmetric GroEL:GroES₂ complexes are the protein-folding functional form of the chaperonin nanomachine

    Dong Yang, Xiang Ye, and George H. Lorimer

    PNAS November 12, 2013 110 (46) E4298-E4305; https://doi.org/10.1073/pnas.1318862110

    See companion article:

    • Substrate protein switches GroE chaperonins from asymmetric to symmetric cycling by catalyzing nucleotide exchange

      - Nov 12, 2013
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    Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants

    Carlos J. López, Zhongyu Yang, Christian Altenbach, and Wayne L. Hubbell

    PNAS November 12, 2013 110 (46) E4306-E4315; https://doi.org/10.1073/pnas.1318754110
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    Keratins significantly contribute to cell stiffness and impact invasive behavior

    Kristin Seltmann, Anatol W. Fritsch, Josef A. Käs, and Thomas M. Magin

    PNAS November 12, 2013 110 (46) 18507-18512; https://doi.org/10.1073/pnas.1310493110

    See companion article:

    • Keratins as the main component for the mechanical integrity of keratinocytes

      - Nov 12, 2013
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    Keratins as the main component for the mechanical integrity of keratinocytes

    Lena Ramms, Gloria Fabris, Reinhard Windoffer, Nicole Schwarz, Ronald Springer, Chen Zhou, Jaroslav Lazar, Simone Stiefel, Nils Hersch, Uwe Schnakenberg, Thomas M. Magin, Rudolf E. Leube, Rudolf Merkel, and Bernd Hoffmann

    PNAS November 12, 2013 110 (46) 18513-18518; https://doi.org/10.1073/pnas.1313491110

    See companion article:

    • Keratins significantly contribute to cell stiffness and impact invasive behavior

      - Nov 12, 2013
  • Open Access

    Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling

    Xiaolin Nan, Eric A. Collisson, Sophia Lewis, Jing Huang, Tanja M. Tamgüney, Jan T. Liphardt, Frank McCormick, Joe W. Gray, and Steven Chu

    PNAS November 12, 2013 110 (46) 18519-18524; https://doi.org/10.1073/pnas.1318188110
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    Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes

    Andrew J. Glowacki, Sayuri Yoshizawa, Siddharth Jhunjhunwala, Andreia E. Vieira, Gustavo P. Garlet, Charles Sfeir, and Steven R. Little

    PNAS November 12, 2013 110 (46) 18525-18530; https://doi.org/10.1073/pnas.1302829110
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    Cell responses only partially shape cell-to-cell variations in protein abundances in Escherichia coli chemotaxis

    Sayak Mukherjee, Sang-Cheol Seok, Veronica J. Vieland, and Jayajit Das

    PNAS November 12, 2013 110 (46) 18531-18536; https://doi.org/10.1073/pnas.1311069110

• Cell Biology

  • Open Access

    Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes

    Nathaniel P. Hoyle and David Ish-Horowicz

    PNAS November 12, 2013 110 (46) E4316-E4324; https://doi.org/10.1073/pnas.1308811110
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    Epstein–Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2

    Daniel Portal, Hufeng Zhou, Bo Zhao, Peter V. Kharchenko, Elizabeth Lowry, Limsoon Wong, John Quackenbush, Dustin Holloway, Sizun Jiang, Yong Lu, and Elliott Kieff

    PNAS November 12, 2013 110 (46) 18537-18542; https://doi.org/10.1073/pnas.1317608110

• Developmental Biology

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    Ca²⁺ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways

    Hiroyuki Tateno, Dario Krapf, Toshiaki Hino, Claudia Sánchez-Cárdenas, Alberto Darszon, Ryuzo Yanagimachi, and Pablo E. Visconti

    PNAS November 12, 2013 110 (46) 18543-18548; https://doi.org/10.1073/pnas.1317113110
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    Numb-deficient satellite cells have regeneration and proliferation defects

    Rajani M. George, Stefano Biressi, Brian J. Beres, Erik Rogers, Amanda K. Mulia, Ronald E. Allen, Alan Rawls, Thomas A. Rando, and Jeanne Wilson-Rawls

    PNAS November 12, 2013 110 (46) 18549-18554; https://doi.org/10.1073/pnas.1311628110
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    Odd-skipped related-1 controls neural crest chondrogenesis during tongue development

    Han Liu, Yu Lan, Jingyue Xu, Ching-Fang Chang, Samantha A. Brugmann, and Rulang Jiang

    PNAS November 12, 2013 110 (46) 18555-18560; https://doi.org/10.1073/pnas.1306495110

• Ecology

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    Microclimate moderates plant responses to macroclimate warming

    Pieter De Frenne, Francisco Rodríguez-Sánchez, David Anthony Coomes, Lander Baeten, Gorik Verstraeten, Mark Vellend, Markus Bernhardt-Römermann, Carissa D. Brown, Jörg Brunet, Johnny Cornelis, Guillaume M. Decocq, Hartmut Dierschke, Ove Eriksson, Frank S. Gilliam, Radim Hédl, Thilo Heinken, Martin Hermy, Patrick Hommel, Michael A. Jenkins, Daniel L. Kelly, Keith J. Kirby, Fraser J. G. Mitchell, Tobias Naaf, Miles Newman, George Peterken, Petr Petřík, Jan Schultz, Grégory Sonnier, Hans Van Calster, Donald M. Waller, Gian-Reto Walther, Peter S. White, Kerry D. Woods, Monika Wulf, Bente Jessen Graae, and Kris Verheyen

    PNAS November 12, 2013 110 (46) 18561-18565; https://doi.org/10.1073/pnas.1311190110

    See companion article:

    • Reply to Harwood et al.: Thermophilization estimation is robust to the scale of species distribution data

      - Apr 01, 2014

• Evolution

  • Open Access

    Topology of viral evolution

    Joseph Minhow Chan, Gunnar Carlsson, and Raul Rabadan

    PNAS November 12, 2013 110 (46) 18566-18571; https://doi.org/10.1073/pnas.1313480110
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    Rapidly evolving R genes in diverse grass species confer resistance to rice blast disease

    Sihai Yang, Jing Li, Xiaohui Zhang, Qijun Zhang, Ju Huang, Jian-Qun Chen, Daniel L. Hartl, and Dacheng Tian

    PNAS November 12, 2013 110 (46) 18572-18577; https://doi.org/10.1073/pnas.1318211110
  • You have access

    Developmental origins of the world’s largest flowers, Rafflesiaceae

    • From the Cover

    Lachezar A. Nikolov, Peter K. Endress, M. Sugumaran, Sawitree Sasirat, Suyanee Vessabutr, Elena M. Kramer, and Charles C. Davis

    PNAS November 12, 2013 110 (46) 18578-18583; https://doi.org/10.1073/pnas.1310356110
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    Large-scale detection of in vivo transcription errors

    Jean-François Gout, W. Kelley Thomas, Zachary Smith, Kazufusa Okamoto, and Michael Lynch

    PNAS November 12, 2013 110 (46) 18584-18589; https://doi.org/10.1073/pnas.1309843110
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    Polynucleobacter necessarius, a model for genome reduction in both free-living and symbiotic bacteria

    Vittorio Boscaro, Michele Felletti, Claudia Vannini, Matthew S. Ackerman, Patrick S. G. Chain, Stephanie Malfatti, Lisa M. Vergez, Maria Shin, Thomas G. Doak, Michael Lynch, and Giulio Petroni

    PNAS November 12, 2013 110 (46) 18590-18595; https://doi.org/10.1073/pnas.1316687110

• Genetics

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    Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups

    Laura A. Genovesi, Ching Ging Ng, Melissa J. Davis, Marc Remke, Michael D. Taylor, David J. Adams, Alistair G. Rust, Jerrold M. Ward, Kenneth H. Ban, Nancy A. Jenkins, Neal G. Copeland, and Brandon J. Wainwright

    PNAS November 12, 2013 110 (46) E4325-E4334; https://doi.org/10.1073/pnas.1318639110
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    Hypermutability and error catastrophe due to defects in ribonucleotide reductase

    Deepti Ahluwalia and Roel M. Schaaper

    PNAS November 12, 2013 110 (46) 18596-18601; https://doi.org/10.1073/pnas.1310849110
  • Open Access

    Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins

    Leonid Teytelman, Deborah M. Thurtle, Jasper Rine, and Alexander van Oudenaarden

    PNAS November 12, 2013 110 (46) 18602-18607; https://doi.org/10.1073/pnas.1316064110

• Immunology

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    Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation

    Hui-fang Zhou, Huimin Yan, Paula Bertram, Ying Hu, Luke E. Springer, Robert W. Thompson, John A. Curci, Dennis E. Hourcade, and Christine T. N. Pham

    PNAS November 12, 2013 110 (46) E4335-E4344; https://doi.org/10.1073/pnas.1315512110
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    MicroRNA-directed program of cytotoxic CD8⁺ T-cell differentiation

    Sara Trifari, Matthew E. Pipkin, Hozefa S. Bandukwala, Tarmo Äijö, Jed Bassein, Runqiang Chen, Gustavo J. Martinez, and Anjana Rao

    PNAS November 12, 2013 110 (46) 18608-18613; https://doi.org/10.1073/pnas.1317191110
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    Immunosignatures can predict vaccine efficacy

    Joseph Barten Legutki and Stephen Albert Johnston

    PNAS November 12, 2013 110 (46) 18614-18619; https://doi.org/10.1073/pnas.1309390110
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    GATA-1 regulates the generation and function of basophils

    Yuichiro Nei, Kazushige Obata-Ninomiya, Hidemitsu Tsutsui, Kenji Ishiwata, Masayuki Miyasaka, Kenji Matsumoto, Susumu Nakae, Hirotaka Kanuka, Naohiko Inase, and Hajime Karasuyama

    PNAS November 12, 2013 110 (46) 18620-18625; https://doi.org/10.1073/pnas.1311668110
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    Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression

    Hiroyuki Hosokawa, Tomoaki Tanaka, Miki Kato, Kenta Shinoda, Hiroyuki Tohyama, Asami Hanazawa, Yuuki Tamaki, Kiyoshi Hirahara, Ryoji Yagi, Ikue Sakikawa, Atsushi Morita, Morio Nagira, Masha V. Poyurovsky, Yutaka Suzuki, Shinichiro Motohashi, and Toshinori Nakayama

    PNAS November 12, 2013 110 (46) 18626-18631; https://doi.org/10.1073/pnas.1311100110

• Medical Sciences

  • Open Access

    Combining two strategies to improve perfusion and drug delivery in solid tumors

    Triantafyllos Stylianopoulos and Rakesh K. Jain

    PNAS November 12, 2013 110 (46) 18632-18637; https://doi.org/10.1073/pnas.1318415110
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    Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

    Xiaoyang Xu, Kun Xie, Xue-Qing Zhang, Eric M. Pridgen, Ga Young Park, Danica S. Cui, Jinjun Shi, Jun Wu, Philip W. Kantoff, Stephen J. Lippard, Robert Langer, Graham C. Walker, and Omid C. Farokhzad

    PNAS November 12, 2013 110 (46) 18638-18643; https://doi.org/10.1073/pnas.1303958110
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    Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia

    Roberto Tamma, Li Sun, Concetta Cuscito, Ping Lu, Michelangelo Corcelli, Jianhua Li, Graziana Colaianni, Surinder S. Moonga, Adriana Di Benedetto, Maria Grano, Silvia Colucci, Tony Yuen, Maria I. New, Alberta Zallone, and Mone Zaidi

    PNAS November 12, 2013 110 (46) 18644-18649; https://doi.org/10.1073/pnas.1318257110
  • Open Access

    DIM (3,3′-diindolylmethane) confers protection against ionizing radiation by a unique mechanism

    • From the Cover

    Saijun Fan, Qinghui Meng, Jiaying Xu, Yang Jiao, Lin Zhao, Xiaodong Zhang, Fazlul H. Sarkar, Milton L. Brown, Anatoly Dritschilo, and Eliot M. Rosen

    PNAS November 12, 2013 110 (46) 18650-18655; https://doi.org/10.1073/pnas.1308206110

    See companion article:

    • Small molecule derived from a natural product that mitigates radiation injury

      - Nov 12, 2013
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    Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ

    Fenfen Wang, Shannon E. Mullican, Joanna R. DiSpirito, Lindsey C. Peed, and Mitchell A. Lazar

    PNAS November 12, 2013 110 (46) 18656-18661; https://doi.org/10.1073/pnas.1314863110

• Microbiology

  • Open Access

    Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation

    Ida Paciello, Alba Silipo, Luigi Lembo-Fazio, Laura Curcurù, Anna Zumsteg, Gaëlle Noël, Valeria Ciancarella, Luisa Sturiale, Antonio Molinaro, and Maria Lina Bernardini

    PNAS November 12, 2013 110 (46) E4345-E4354; https://doi.org/10.1073/pnas.1303641110
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    Atomic-level functional model of dengue virus Envelope protein infectivity

    Elizabeth A. Christian, Kristen M. Kahle, Kimberly Mattia, Bridget A. Puffer, Jennifer M. Pfaff, Adam Miller, Cheryl Paes, Edgar Davidson, and Benjamin J. Doranz

    PNAS November 12, 2013 110 (46) 18662-18667; https://doi.org/10.1073/pnas.1310962110
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    Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3

    Tadaki Suzuki, Yasuko Orba, Yoshinori Makino, Yuki Okada, Yuji Sunden, Hideki Hasegawa, William W. Hall, and Hirofumi Sawa

    PNAS November 12, 2013 110 (46) 18668-18673; https://doi.org/10.1073/pnas.1311457110
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    Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex

    Melissa A. Farrow, Nicole M. Chumbler, Lynne A. Lapierre, Jeffrey L. Franklin, Stacey A. Rutherford, James R. Goldenring, and D. Borden Lacy

    PNAS November 12, 2013 110 (46) 18674-18679; https://doi.org/10.1073/pnas.1313658110

• Neuroscience

  • Open Access

    A neuropeptide speeds circadian entrainment by reducing intercellular synchrony

    Sungwon An, Rich Harang, Kirsten Meeker, Daniel Granados-Fuentes, Connie A. Tsai, Cristina Mazuski, Jihee Kim, Francis J. Doyle III, Linda R. Petzold, and Erik D. Herzog

    PNAS November 12, 2013 110 (46) E4355-E4361; https://doi.org/10.1073/pnas.1307088110
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    Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase

    Tina I. Lam, Angela M. Brennan-Minnella, Seok Joon Won, Yiguo Shen, Colleen Hefner, Yejie Shi, Dandan Sun, and Raymond A. Swanson

    PNAS November 12, 2013 110 (46) E4362-E4368; https://doi.org/10.1073/pnas.1313029110
  • Open Access

    Human genome–guided identification of memory-modulating drugs

    Andreas Papassotiropoulos, Christiane Gerhards, Angela Heck, Sandra Ackermann, Amanda Aerni, Nathalie Schicktanz, Bianca Auschra, Philippe Demougin, Eva Mumme, Thomas Elbert, Verena Ertl, Leo Gschwind, Edveena Hanser, Kim-Dung Huynh, Frank Jessen, Iris-Tatjana Kolassa, Annette Milnik, Paolo Paganetti, Klara Spalek, Christian Vogler, Andreas Muhs, Andrea Pfeifer, and Dominique J.-F. de Quervain

    PNAS November 12, 2013 110 (46) E4369-E4374; https://doi.org/10.1073/pnas.1314478110
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    Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism

    Daniella Rylander, Vincenza Bagetta, Valentina Pendolino, Elisa Zianni, Shane Grealish, Fabrizio Gardoni, Monica Di Luca, Paolo Calabresi, M. Angela Cenci, and Barbara Picconi

    PNAS November 12, 2013 110 (46) E4375-E4384; https://doi.org/10.1073/pnas.1311187110
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    C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

    Christian S. Lobsiger, Severine Boillée, Christine Pozniak, Amir M. Khan, Melissa McAlonis-Downes, Joseph W. Lewcock, and Don W. Cleveland

    PNAS November 12, 2013 110 (46) E4385-E4392; https://doi.org/10.1073/pnas.1318309110

    See companion article:

    • Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice

      - Jan 07, 2014
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    High-speed laser microsurgery of alert fruit flies for fluorescence imaging of neural activity

    Supriyo Sinha, Liang Liang, Eric T. W. Ho, Karel E. Urbanek, Liqun Luo, Thomas M. Baer, and Mark J. Schnitzer

    PNAS November 12, 2013 110 (46) 18374-18379; https://doi.org/10.1073/pnas.1216287110
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    Pheromone discrimination by a pH-tuned polymorphism of the Bombyx mori pheromone-binding protein

    Fred F. Damberger, Erich Michel, Yuko Ishida, Walter S. Leal, and Kurt Wüthrich

    PNAS November 12, 2013 110 (46) 18680-18685; https://doi.org/10.1073/pnas.1317706110
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    A universal strategy for visually guided landing

    Emily Baird, Norbert Boeddeker, Michael R. Ibbotson, and Mandyam V. Srinivasan

    PNAS November 12, 2013 110 (46) 18686-18691; https://doi.org/10.1073/pnas.1314311110
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    Mind wandering away from pain dynamically engages antinociceptive and default mode brain networks

    Aaron Kucyi, Tim V. Salomons, and Karen D. Davis

    PNAS November 12, 2013 110 (46) 18692-18697; https://doi.org/10.1073/pnas.1312902110
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    Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3⁺ progenitors and peripheral neurons

    Lynn George, Marta Chaverra, Lindsey Wolfe, Julian Thorne, Mattheson Close-Davis, Amy Eibs, Vickie Riojas, Andrea Grindeland, Miranda Orr, George A. Carlson, and Frances Lefcort

    PNAS November 12, 2013 110 (46) 18698-18703; https://doi.org/10.1073/pnas.1308596110
  • Open Access

    Differential expression of olfactory genes in the southern house mosquito and insights into unique odorant receptor gene isoforms

    Walter S. Leal, Young-Moo Choo, Pingxi Xu, Cherre S. B. da Silva, and Carlos Ueira-Vieira

    PNAS November 12, 2013 110 (46) 18704-18709; https://doi.org/10.1073/pnas.1316059110

• Physiology

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    Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction

    Daniela Wenzel, Michaela Matthey, Laura Bindila, Raissa Lerner, Beat Lutz, Andreas Zimmer, and Bernd K. Fleischmann

    PNAS November 12, 2013 110 (46) 18710-18715; https://doi.org/10.1073/pnas.1308130110
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    Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography

    Giovanni Gonzalez-Gutierrez, Luis G. Cuello, Satish K. Nair, and Claudio Grosman

    PNAS November 12, 2013 110 (46) 18716-18721; https://doi.org/10.1073/pnas.1313156110

• Plant Biology

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    The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a

    Jennifer D. Lewis, Amy Huei-Yi Lee, Jana A. Hassan, Janet Wan, Brenden Hurley, Jacquelyn R. Jhingree, Pauline W. Wang, Timothy Lo, Ji-Young Youn, David S. Guttman, and Darrell Desveaux

    PNAS November 12, 2013 110 (46) 18722-18727; https://doi.org/10.1073/pnas.1315520110

• Psychological and Cognitive Sciences

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    Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood

    Pilyoung Kim, Gary W. Evans, Michael Angstadt, S. Shaun Ho, Chandra S. Sripada, James E. Swain, Israel Liberzon, and K. Luan Phan

    PNAS November 12, 2013 110 (46) 18442-18447; https://doi.org/10.1073/pnas.1308240110
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    First-person action experience reveals sensitivity to action efficiency in prereaching infants

    Amy E. Skerry, Susan E. Carey, and Elizabeth S. Spelke

    PNAS November 12, 2013 110 (46) 18728-18733; https://doi.org/10.1073/pnas.1312322110

• Systems Biology

  • Open Access

    Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes

    Patrick A. Gibney, Charles Lu, Amy A. Caudy, David C. Hess, and David Botstein

    PNAS November 12, 2013 110 (46) E4393-E4402; https://doi.org/10.1073/pnas.1318100110