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Table of Contents

November 12, 2013; vol. 110 no. 46

This Week in PNAS

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    In This Issue
    PNAS November 12, 2013 110 (46) 18341-18342; https://doi.org/10.1073/iti4613110

Letters (Online Only)

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    Negative production of acetoin in the photochemistry of aqueous pyruvic acid
    Alexis J. Eugene, Sha-Sha Xia, and Marcelo I. Guzman
    PNAS November 12, 2013 110 (46) E4274-E4275; https://doi.org/10.1073/pnas.1313991110
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    Reply to Eugene et al.: Photochemistry of aqueous pyruvic acid
    Elizabeth C. Griffith, Barry K. Carpenter, Richard K. Shoemaker, and Veronica Vaida
    PNAS November 12, 2013 110 (46) E4276; https://doi.org/10.1073/pnas.1316367110

    See companion article:

    • Photochemistry of aqueous pyruvic acid
      - Jul 02, 2013
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    No bull: Upholding community standards in public sharing of biological datasets
    Jennifer F. Hughes, Helen Skaletsky, D. Winston Bellott, Bhanu P. Chowdhary, Wesley C. Warren, Kim C. Worley, Richard K. Wilson, Richard A. Gibbs, and David C. Page
    PNAS November 12, 2013 110 (46) E4277; https://doi.org/10.1073/pnas.1315122110
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    Reply to Hughes et al.: No bullying: Publications comply with international standards
    Wan-Sheng Liu, Ti-Cheng Chang, and Yang Yang
    PNAS November 12, 2013 110 (46) E4278; https://doi.org/10.1073/pnas.1316664110

    See companion article:

    • Bovine Y is gene rich
      - Jul 10, 2013

Core Concepts

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    Brain–machine interface
    • Front Matter
    Prashant Nair
    PNAS November 12, 2013 110 (46) 18343; https://doi.org/10.1073/pnas.1319310110

Retrospective

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    Hugh Esmor Huxley (1924–2013)
    Kenneth C. Holmes
    PNAS November 12, 2013 110 (46) 18344-18345; https://doi.org/10.1073/pnas.1318966110

Profiles

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    Profile of Richard Eisenberg
    Nicholette Zeliadt
    PNAS November 12, 2013 110 (46) 18346-18348; https://doi.org/10.1073/pnas.1319293110

    See companion article:

    • Surface exchange in photogeneration of hydrogen
      - Sep 30, 2013
  • You have access
    Profile of Thomas Südhof, James Rothman, and Randy Schekman, 2013 Nobel Laureates in Physiology or Medicine
    William T. Wickner
    PNAS November 12, 2013 110 (46) 18349-18350; https://doi.org/10.1073/pnas.1319309110

Commentaries

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    Hypoxia and inflammation are two sides of the same coin
    Karsten Bartels, Almut Grenz, and Holger K. Eltzschig
    PNAS November 12, 2013 110 (46) 18351-18352; https://doi.org/10.1073/pnas.1318345110

    See companion article:

    • Hydroxylases regulate IL-1β signaling
      - Oct 21, 2013
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    A mosquito’s last supper reminds us not to underestimate the fossil record
    Derek E. G. Briggs
    PNAS November 12, 2013 110 (46) 18353-18354; https://doi.org/10.1073/pnas.1319306110

    See companion article:

    • Porphyrins in a blood-engorged fossil mosquito
      - Oct 14, 2013
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    Small molecule derived from a natural product that mitigates radiation injury
    Philip P. Connell and Ralph R. Weichselbaum
    PNAS November 12, 2013 110 (46) 18355-18356; https://doi.org/10.1073/pnas.1318343110

    See companion article:

    • DIM protects against ionizing radiation
      - Oct 14, 2013

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.
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    PNAS Plus Significance Statements
    PNAS November 12, 2013 110 (46) 18357-18359; https://doi.org/10.1073/pnas.ss11046

Perspective

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    Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health
    Graham A. Rook
    PNAS November 12, 2013 110 (46) 18360-18367; https://doi.org/10.1073/pnas.1313731110

Physical Sciences

  • Applied Mathematics

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      Compressed modes for variational problems in mathematics and physics
      Vidvuds Ozoliņš, Rongjie Lai, Russel Caflisch, and Stanley Osher
      PNAS November 12, 2013 110 (46) 18368-18373; https://doi.org/10.1073/pnas.1318679110
  • Applied Physical Sciences

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      High-speed laser microsurgery of alert fruit flies for fluorescence imaging of neural activity
      Supriyo Sinha, Liang Liang, Eric T. W. Ho, Karel E. Urbanek, Liqun Luo, Thomas M. Baer, and Mark J. Schnitzer
      PNAS November 12, 2013 110 (46) 18374-18379; https://doi.org/10.1073/pnas.1216287110
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      3D printing of microscopic bacterial communities
      • From the Cover
      Jodi L. Connell, Eric T. Ritschdorff, Marvin Whiteley, and Jason B. Shear
      PNAS November 12, 2013 110 (46) 18380-18385; https://doi.org/10.1073/pnas.1309729110
    • Open Access
      Plasmonic antennas as design elements for coherent ultrafast nanophotonics
      Daan Brinks, Marta Castro-Lopez, Richard Hildner, and Niek F. van Hulst
      PNAS November 12, 2013 110 (46) 18386-18390; https://doi.org/10.1073/pnas.1308652110
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      Submillisecond second harmonic holographic imaging of biological specimens in three dimensions
      David R. Smith, David G. Winters, and Randy A. Bartels
      PNAS November 12, 2013 110 (46) 18391-18396; https://doi.org/10.1073/pnas.1306856110
  • Chemistry

    • Open Access
      Electrolytic synthesis of aqueous aluminum nanoclusters and in situ characterization by femtosecond Raman spectroscopy and computations
      Wei Wang, Weimin Liu, I-Ya Chang, Lindsay A. Wills, Lev N. Zakharov, Shannon W. Boettcher, Paul Ha-Yeon Cheong, Chong Fang, and Douglas A. Keszler
      PNAS November 12, 2013 110 (46) 18397-18401; https://doi.org/10.1073/pnas.1315396110
  • Earth, Atmospheric, and Planetary Sciences

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      Electronic structure of carbon dioxide under pressure and insights into the molecular-to-nonmolecular transition
      Sean R. Shieh, Ignace Jarrige, Min Wu, Nozomu Hiraoka, John S. Tse, Zhongying Mi, Linada Kaci, Jian-Zhong Jiang, and Yong Q. Cai
      PNAS November 12, 2013 110 (46) 18402-18406; https://doi.org/10.1073/pnas.1305116110
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      Sulfur isotopes track the global extent and dynamics of euxinia during Cretaceous Oceanic Anoxic Event 2
      Jeremy D. Owens, Benjamin C. Gill, Hugh C. Jenkyns, Steven M. Bates, Silke Severmann, Marcel M. M. Kuypers, Richard G. Woodfine, and Timothy W. Lyons
      PNAS November 12, 2013 110 (46) 18407-18412; https://doi.org/10.1073/pnas.1305304110
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      Sulfur isotope homogeneity of oceanic DMSP and DMS
      Alon Amrani, Ward Said-Ahmad, Yeala Shaked, and Ronald P. Kiene
      PNAS November 12, 2013 110 (46) 18413-18418; https://doi.org/10.1073/pnas.1312956110
  • Engineering

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      Enhanced fatigue endurance of metallic glasses through a staircase-like fracture mechanism
      Bernd Gludovatz, Marios D. Demetriou, Michael Floyd, Anton Hohenwarter, William L. Johnson, and Robert O. Ritchie
      PNAS November 12, 2013 110 (46) 18419-18424; https://doi.org/10.1073/pnas.1317715110
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      High-performance, low-voltage electroosmotic pumps with molecularly thin silicon nanomembranes
      Jessica L. Snyder, Jirachai Getpreecharsawas, David Z. Fang, Thomas R. Gaborski, Christopher C. Striemer, Philippe M. Fauchet, David A. Borkholder, and James L. McGrath
      PNAS November 12, 2013 110 (46) 18425-18430; https://doi.org/10.1073/pnas.1308109110
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      Designing DNA-grafted particles that self-assemble into desired crystalline structures using the genetic algorithm
      Babji Srinivasan, Thi Vo, Yugang Zhang, Oleg Gang, Sanat Kumar, and Venkat Venkatasubramanian
      PNAS November 12, 2013 110 (46) 18431-18435; https://doi.org/10.1073/pnas.1316533110
    • Open Access
      Combining two strategies to improve perfusion and drug delivery in solid tumors
      Triantafyllos Stylianopoulos and Rakesh K. Jain
      PNAS November 12, 2013 110 (46) 18632-18637; https://doi.org/10.1073/pnas.1318415110
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      Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug
      Xiaoyang Xu, Kun Xie, Xue-Qing Zhang, Eric M. Pridgen, Ga Young Park, Danica S. Cui, Jinjun Shi, Jun Wu, Philip W. Kantoff, Stephen J. Lippard, Robert Langer, Graham C. Walker, and Omid C. Farokhzad
      PNAS November 12, 2013 110 (46) 18638-18643; https://doi.org/10.1073/pnas.1303958110
  • Environmental Sciences

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      Enduring legacy of a toxic fan via episodic redistribution of California gold mining debris
      Michael Bliss Singer, Rolf Aalto, L. Allan James, Nina E. Kilham, John L. Higson, and Subhajit Ghoshal
      PNAS November 12, 2013 110 (46) 18436-18441; https://doi.org/10.1073/pnas.1302295110
  • Mathematics

    • Open Access
      Topology of viral evolution
      Joseph Minhow Chan, Gunnar Carlsson, and Raul Rabadan
      PNAS November 12, 2013 110 (46) 18566-18571; https://doi.org/10.1073/pnas.1313480110
  • Physics

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      Keratins significantly contribute to cell stiffness and impact invasive behavior
      Kristin Seltmann, Anatol W. Fritsch, Josef A. Käs, and Thomas M. Magin
      PNAS November 12, 2013 110 (46) 18507-18512; https://doi.org/10.1073/pnas.1310493110

      See companion article:

      • Keratin-dependent cell mechanics
        - Oct 28, 2013
    • You have access
      Keratins as the main component for the mechanical integrity of keratinocytes
      Lena Ramms, Gloria Fabris, Reinhard Windoffer, Nicole Schwarz, Ronald Springer, Chen Zhou, Jaroslav Lazar, Simone Stiefel, Nils Hersch, Uwe Schnakenberg, Thomas M. Magin, Rudolf E. Leube, Rudolf Merkel, and Bernd Hoffmann
      PNAS November 12, 2013 110 (46) 18513-18518; https://doi.org/10.1073/pnas.1313491110

      See companion article:

      • Keratins role in cell stiffness and invasion
        - Oct 28, 2013

Social Sciences

  • Psychological and Cognitive Sciences

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      Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood
      Pilyoung Kim, Gary W. Evans, Michael Angstadt, S. Shaun Ho, Chandra S. Sripada, James E. Swain, Israel Liberzon, and K. Luan Phan
      PNAS November 12, 2013 110 (46) 18442-18447; https://doi.org/10.1073/pnas.1308240110
    • Open Access
      Grammatical morphology as a source of early number word meanings
      Alhanouf Almoammer, Jessica Sullivan, Chris Donlan, Franc Marušič, Rok Žaucer, Timothy O’Donnell, and David Barner
      PNAS November 12, 2013 110 (46) 18448-18453; https://doi.org/10.1073/pnas.1313652110
  • Sustainability Science

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      Elevated rates of gold mining in the Amazon revealed through high-resolution monitoring
      Gregory P. Asner, William Llactayo, Raul Tupayachi, and Ernesto Ráez Luna
      PNAS November 12, 2013 110 (46) 18454-18459; https://doi.org/10.1073/pnas.1318271110

Biological Sciences

  • Applied Biological Sciences

    • Open Access
      Quantitative selection and parallel characterization of aptamers
      Minseon Cho, Seung Soo Oh, Jeff Nie, Ron Stewart, Michael Eisenstein, James Chambers, Jamey D. Marth, Faye Walker, James A. Thomson, and H. Tom Soh
      PNAS November 12, 2013 110 (46) 18460-18465; https://doi.org/10.1073/pnas.1315866110
    • Open Access
      Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees
      • Cozzarelli Prize Winner
      Gennaro Di Prisco, Valeria Cavaliere, Desiderato Annoscia, Paola Varricchio, Emilio Caprio, Francesco Nazzi, Giuseppe Gargiulo, and Francesco Pennacchio
      PNAS November 12, 2013 110 (46) 18466-18471; https://doi.org/10.1073/pnas.1314923110
  • Biochemistry

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      Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain
      Helena Öhrvik, Yasuhiro Nose, L. Kent Wood, Byung-Eun Kim, Sophie-Charlotte Gleber, Martina Ralle, and Dennis J. Thiele
      PNAS November 12, 2013 110 (46) E4279-E4288; https://doi.org/10.1073/pnas.1311749110
    • Open Access
      Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins
      Nikki Bowen, Catherine E. Smith, Anjana Srivatsan, Smaranda Willcox, Jack D. Griffith, and Richard D. Kolodner
      PNAS November 12, 2013 110 (46) 18472-18477; https://doi.org/10.1073/pnas.1318971110
    • You have access
      Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ
      Claudine Baraquet and Caroline S. Harwood
      PNAS November 12, 2013 110 (46) 18478-18483; https://doi.org/10.1073/pnas.1318972110
    • You have access
      Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter
      John Edward Pak, Elisabeth Ngonlong Ekendé, Efrem G. Kifle, Joseph Daniel O’Connell III, Fabien De Angelis, Meseret B. Tessema, Kheiro-Mouna Derfoufi, Yaneth Robles-Colmenares, Rebecca A. Robbins, Erik Goormaghtigh, Guy Vandenbussche, and Robert M. Stroud
      PNAS November 12, 2013 110 (46) 18484-18489; https://doi.org/10.1073/pnas.1318705110
    • You have access
      Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways
      • From the Cover
      Carsten C. Scholz, Miguel A. S. Cavadas, Murtaza M. Tambuwala, Emily Hams, Javier Rodríguez, Alex von Kriegsheim, Philip Cotter, Ulrike Bruning, Padraic G. Fallon, Alex Cheong, Eoin P. Cummins, and Cormac T. Taylor
      PNAS November 12, 2013 110 (46) 18490-18495; https://doi.org/10.1073/pnas.1309718110

      See companion article:

      • Hypoxia and inflammation
        - Nov 01, 2013
    • You have access
      Hemoglobin-derived porphyrins preserved in a Middle Eocene blood-engorged mosquito
      • From the Cover
      Dale E. Greenwalt, Yulia S. Goreva, Sandra M. Siljeström, Tim Rose, and Ralph E. Harbach
      PNAS November 12, 2013 110 (46) 18496-18500; https://doi.org/10.1073/pnas.1310885110

      See companion article:

      • Fossil mosquito's last supper
        - Nov 01, 2013
    • You have access
      Cytosolic reducing power preserves glutamate in retina
      Jianhai Du, Whitney Cleghorn, Laura Contreras, Jonathan D. Linton, Guy C.-K. Chan, Andrei O. Chertov, Takeyori Saheki, Viren Govindaraju, Martin Sadilek, Jorgina Satrústegui, and James B. Hurley
      PNAS November 12, 2013 110 (46) 18501-18506; https://doi.org/10.1073/pnas.1311193110
  • Biophysics and Computational Biology

    • Open Access
      Substrate protein switches GroE chaperonins from asymmetric to symmetric cycling by catalyzing nucleotide exchange
      Xiang Ye and George H. Lorimer
      PNAS November 12, 2013 110 (46) E4289-E4297; https://doi.org/10.1073/pnas.1317702110

      See companion article:

      • Symmetric GroEL:GroES2 is the folding active form
        - Oct 28, 2013
    • Open Access
      Symmetric GroEL:GroES2 complexes are the protein-folding functional form of the chaperonin nanomachine
      Dong Yang, Xiang Ye, and George H. Lorimer
      PNAS November 12, 2013 110 (46) E4298-E4305; https://doi.org/10.1073/pnas.1318862110

      See companion article:

      • Substrate protein changes the kinetic mechanism
        - Oct 28, 2013
    • You have access
      Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants
      Carlos J. López, Zhongyu Yang, Christian Altenbach, and Wayne L. Hubbell
      PNAS November 12, 2013 110 (46) E4306-E4315; https://doi.org/10.1073/pnas.1318754110
    • You have access
      Keratins significantly contribute to cell stiffness and impact invasive behavior
      Kristin Seltmann, Anatol W. Fritsch, Josef A. Käs, and Thomas M. Magin
      PNAS November 12, 2013 110 (46) 18507-18512; https://doi.org/10.1073/pnas.1310493110

      See companion article:

      • Keratin-dependent cell mechanics
        - Oct 28, 2013
    • You have access
      Keratins as the main component for the mechanical integrity of keratinocytes
      Lena Ramms, Gloria Fabris, Reinhard Windoffer, Nicole Schwarz, Ronald Springer, Chen Zhou, Jaroslav Lazar, Simone Stiefel, Nils Hersch, Uwe Schnakenberg, Thomas M. Magin, Rudolf E. Leube, Rudolf Merkel, and Bernd Hoffmann
      PNAS November 12, 2013 110 (46) 18513-18518; https://doi.org/10.1073/pnas.1313491110

      See companion article:

      • Keratins role in cell stiffness and invasion
        - Oct 28, 2013
    • Open Access
      Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling
      Xiaolin Nan, Eric A. Collisson, Sophia Lewis, Jing Huang, Tanja M. Tamgüney, Jan T. Liphardt, Frank McCormick, Joe W. Gray, and Steven Chu
      PNAS November 12, 2013 110 (46) 18519-18524; https://doi.org/10.1073/pnas.1318188110
    • You have access
      Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes
      Andrew J. Glowacki, Sayuri Yoshizawa, Siddharth Jhunjhunwala, Andreia E. Vieira, Gustavo P. Garlet, Charles Sfeir, and Steven R. Little
      PNAS November 12, 2013 110 (46) 18525-18530; https://doi.org/10.1073/pnas.1302829110
    • You have access
      Cell responses only partially shape cell-to-cell variations in protein abundances in Escherichia coli chemotaxis
      Sayak Mukherjee, Sang-Cheol Seok, Veronica J. Vieland, and Jayajit Das
      PNAS November 12, 2013 110 (46) 18531-18536; https://doi.org/10.1073/pnas.1311069110
  • Cell Biology

    • Open Access
      Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes
      Nathaniel P. Hoyle and David Ish-Horowicz
      PNAS November 12, 2013 110 (46) E4316-E4324; https://doi.org/10.1073/pnas.1308811110
    • You have access
      Epstein–Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2
      Daniel Portal, Hufeng Zhou, Bo Zhao, Peter V. Kharchenko, Elizabeth Lowry, Limsoon Wong, John Quackenbush, Dustin Holloway, Sizun Jiang, Yong Lu, and Elliott Kieff
      PNAS November 12, 2013 110 (46) 18537-18542; https://doi.org/10.1073/pnas.1317608110
  • Developmental Biology

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      Ca2+ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways
      Hiroyuki Tateno, Dario Krapf, Toshiaki Hino, Claudia Sánchez-Cárdenas, Alberto Darszon, Ryuzo Yanagimachi, and Pablo E. Visconti
      PNAS November 12, 2013 110 (46) 18543-18548; https://doi.org/10.1073/pnas.1317113110
    • You have access
      Numb-deficient satellite cells have regeneration and proliferation defects
      Rajani M. George, Stefano Biressi, Brian J. Beres, Erik Rogers, Amanda K. Mulia, Ronald E. Allen, Alan Rawls, Thomas A. Rando, and Jeanne Wilson-Rawls
      PNAS November 12, 2013 110 (46) 18549-18554; https://doi.org/10.1073/pnas.1311628110
    • You have access
      Odd-skipped related-1 controls neural crest chondrogenesis during tongue development
      Han Liu, Yu Lan, Jingyue Xu, Ching-Fang Chang, Samantha A. Brugmann, and Rulang Jiang
      PNAS November 12, 2013 110 (46) 18555-18560; https://doi.org/10.1073/pnas.1306495110
  • Ecology

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      Microclimate moderates plant responses to macroclimate warming
      Pieter De Frenne, Francisco Rodríguez-Sánchez, David Anthony Coomes, Lander Baeten, Gorik Verstraeten, Mark Vellend, Markus Bernhardt-Römermann, Carissa D. Brown, Jörg Brunet, Johnny Cornelis, Guillaume M. Decocq, Hartmut Dierschke, Ove Eriksson, Frank S. Gilliam, Radim Hédl, Thilo Heinken, Martin Hermy, Patrick Hommel, Michael A. Jenkins, Daniel L. Kelly, Keith J. Kirby, Fraser J. G. Mitchell, Tobias Naaf, Miles Newman, George Peterken, Petr Petřík, Jan Schultz, Grégory Sonnier, Hans Van Calster, Donald M. Waller, Gian-Reto Walther, Peter S. White, Kerry D. Woods, Monika Wulf, Bente Jessen Graae, and Kris Verheyen
      PNAS November 12, 2013 110 (46) 18561-18565; https://doi.org/10.1073/pnas.1311190110

      See companion article:

      • Robust thermophilization estimation
        - Feb 25, 2014
  • Evolution

    • Open Access
      Topology of viral evolution
      Joseph Minhow Chan, Gunnar Carlsson, and Raul Rabadan
      PNAS November 12, 2013 110 (46) 18566-18571; https://doi.org/10.1073/pnas.1313480110
    • You have access
      Rapidly evolving R genes in diverse grass species confer resistance to rice blast disease
      Sihai Yang, Jing Li, Xiaohui Zhang, Qijun Zhang, Ju Huang, Jian-Qun Chen, Daniel L. Hartl, and Dacheng Tian
      PNAS November 12, 2013 110 (46) 18572-18577; https://doi.org/10.1073/pnas.1318211110
    • You have access
      Developmental origins of the world’s largest flowers, Rafflesiaceae
      • From the Cover
      Lachezar A. Nikolov, Peter K. Endress, M. Sugumaran, Sawitree Sasirat, Suyanee Vessabutr, Elena M. Kramer, and Charles C. Davis
      PNAS November 12, 2013 110 (46) 18578-18583; https://doi.org/10.1073/pnas.1310356110
    • You have access
      Large-scale detection of in vivo transcription errors
      Jean-François Gout, W. Kelley Thomas, Zachary Smith, Kazufusa Okamoto, and Michael Lynch
      PNAS November 12, 2013 110 (46) 18584-18589; https://doi.org/10.1073/pnas.1309843110
    • You have access
      Polynucleobacter necessarius, a model for genome reduction in both free-living and symbiotic bacteria
      Vittorio Boscaro, Michele Felletti, Claudia Vannini, Matthew S. Ackerman, Patrick S. G. Chain, Stephanie Malfatti, Lisa M. Vergez, Maria Shin, Thomas G. Doak, Michael Lynch, and Giulio Petroni
      PNAS November 12, 2013 110 (46) 18590-18595; https://doi.org/10.1073/pnas.1316687110
  • Genetics

    • You have access
      Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups
      Laura A. Genovesi, Ching Ging Ng, Melissa J. Davis, Marc Remke, Michael D. Taylor, David J. Adams, Alistair G. Rust, Jerrold M. Ward, Kenneth H. Ban, Nancy A. Jenkins, Neal G. Copeland, and Brandon J. Wainwright
      PNAS November 12, 2013 110 (46) E4325-E4334; https://doi.org/10.1073/pnas.1318639110
    • You have access
      Hypermutability and error catastrophe due to defects in ribonucleotide reductase
      Deepti Ahluwalia and Roel M. Schaaper
      PNAS November 12, 2013 110 (46) 18596-18601; https://doi.org/10.1073/pnas.1310849110
    • Open Access
      Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins
      Leonid Teytelman, Deborah M. Thurtle, Jasper Rine, and Alexander van Oudenaarden
      PNAS November 12, 2013 110 (46) 18602-18607; https://doi.org/10.1073/pnas.1316064110
  • Immunology

    • You have access
      Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation
      Hui-fang Zhou, Huimin Yan, Paula Bertram, Ying Hu, Luke E. Springer, Robert W. Thompson, John A. Curci, Dennis E. Hourcade, and Christine T. N. Pham
      PNAS November 12, 2013 110 (46) E4335-E4344; https://doi.org/10.1073/pnas.1315512110
    • You have access
      MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation
      Sara Trifari, Matthew E. Pipkin, Hozefa S. Bandukwala, Tarmo Äijö, Jed Bassein, Runqiang Chen, Gustavo J. Martinez, and Anjana Rao
      PNAS November 12, 2013 110 (46) 18608-18613; https://doi.org/10.1073/pnas.1317191110
    • You have access
      Immunosignatures can predict vaccine efficacy
      Joseph Barten Legutki and Stephen Albert Johnston
      PNAS November 12, 2013 110 (46) 18614-18619; https://doi.org/10.1073/pnas.1309390110
    • You have access
      GATA-1 regulates the generation and function of basophils
      Yuichiro Nei, Kazushige Obata-Ninomiya, Hidemitsu Tsutsui, Kenji Ishiwata, Masayuki Miyasaka, Kenji Matsumoto, Susumu Nakae, Hirotaka Kanuka, Naohiko Inase, and Hajime Karasuyama
      PNAS November 12, 2013 110 (46) 18620-18625; https://doi.org/10.1073/pnas.1311668110
    • You have access
      Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression
      Hiroyuki Hosokawa, Tomoaki Tanaka, Miki Kato, Kenta Shinoda, Hiroyuki Tohyama, Asami Hanazawa, Yuuki Tamaki, Kiyoshi Hirahara, Ryoji Yagi, Ikue Sakikawa, Atsushi Morita, Morio Nagira, Masha V. Poyurovsky, Yutaka Suzuki, Shinichiro Motohashi, and Toshinori Nakayama
      PNAS November 12, 2013 110 (46) 18626-18631; https://doi.org/10.1073/pnas.1311100110
  • Medical Sciences

    • Open Access
      Combining two strategies to improve perfusion and drug delivery in solid tumors
      Triantafyllos Stylianopoulos and Rakesh K. Jain
      PNAS November 12, 2013 110 (46) 18632-18637; https://doi.org/10.1073/pnas.1318415110
    • You have access
      Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug
      Xiaoyang Xu, Kun Xie, Xue-Qing Zhang, Eric M. Pridgen, Ga Young Park, Danica S. Cui, Jinjun Shi, Jun Wu, Philip W. Kantoff, Stephen J. Lippard, Robert Langer, Graham C. Walker, and Omid C. Farokhzad
      PNAS November 12, 2013 110 (46) 18638-18643; https://doi.org/10.1073/pnas.1303958110
    • You have access
      Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia
      Roberto Tamma, Li Sun, Concetta Cuscito, Ping Lu, Michelangelo Corcelli, Jianhua Li, Graziana Colaianni, Surinder S. Moonga, Adriana Di Benedetto, Maria Grano, Silvia Colucci, Tony Yuen, Maria I. New, Alberta Zallone, and Mone Zaidi
      PNAS November 12, 2013 110 (46) 18644-18649; https://doi.org/10.1073/pnas.1318257110
    • Open Access
      DIM (3,3′-diindolylmethane) confers protection against ionizing radiation by a unique mechanism
      • From the Cover
      Saijun Fan, Qinghui Meng, Jiaying Xu, Yang Jiao, Lin Zhao, Xiaodong Zhang, Fazlul H. Sarkar, Milton L. Brown, Anatoly Dritschilo, and Eliot M. Rosen
      PNAS November 12, 2013 110 (46) 18650-18655; https://doi.org/10.1073/pnas.1308206110

      See companion article:

      • A small molecule that mitigates radiation injury
        - Nov 01, 2013
    • You have access
      Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ
      Fenfen Wang, Shannon E. Mullican, Joanna R. DiSpirito, Lindsey C. Peed, and Mitchell A. Lazar
      PNAS November 12, 2013 110 (46) 18656-18661; https://doi.org/10.1073/pnas.1314863110
  • Microbiology

    • Open Access
      Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation
      Ida Paciello, Alba Silipo, Luigi Lembo-Fazio, Laura Curcurù, Anna Zumsteg, Gaëlle Noël, Valeria Ciancarella, Luisa Sturiale, Antonio Molinaro, and Maria Lina Bernardini
      PNAS November 12, 2013 110 (46) E4345-E4354; https://doi.org/10.1073/pnas.1303641110
    • You have access
      Atomic-level functional model of dengue virus Envelope protein infectivity
      Elizabeth A. Christian, Kristen M. Kahle, Kimberly Mattia, Bridget A. Puffer, Jennifer M. Pfaff, Adam Miller, Cheryl Paes, Edgar Davidson, and Benjamin J. Doranz
      PNAS November 12, 2013 110 (46) 18662-18667; https://doi.org/10.1073/pnas.1310962110
    • You have access
      Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3
      Tadaki Suzuki, Yasuko Orba, Yoshinori Makino, Yuki Okada, Yuji Sunden, Hideki Hasegawa, William W. Hall, and Hirofumi Sawa
      PNAS November 12, 2013 110 (46) 18668-18673; https://doi.org/10.1073/pnas.1311457110
    • You have access
      Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex
      Melissa A. Farrow, Nicole M. Chumbler, Lynne A. Lapierre, Jeffrey L. Franklin, Stacey A. Rutherford, James R. Goldenring, and D. Borden Lacy
      PNAS November 12, 2013 110 (46) 18674-18679; https://doi.org/10.1073/pnas.1313658110
  • Neuroscience

    • Open Access
      A neuropeptide speeds circadian entrainment by reducing intercellular synchrony
      Sungwon An, Rich Harang, Kirsten Meeker, Daniel Granados-Fuentes, Connie A. Tsai, Cristina Mazuski, Jihee Kim, Francis J. Doyle III, Linda R. Petzold, and Erik D. Herzog
      PNAS November 12, 2013 110 (46) E4355-E4361; https://doi.org/10.1073/pnas.1307088110
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      Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase
      Tina I. Lam, Angela M. Brennan-Minnella, Seok Joon Won, Yiguo Shen, Colleen Hefner, Yejie Shi, Dandan Sun, and Raymond A. Swanson
      PNAS November 12, 2013 110 (46) E4362-E4368; https://doi.org/10.1073/pnas.1313029110
    • Open Access
      Human genome–guided identification of memory-modulating drugs
      Andreas Papassotiropoulos, Christiane Gerhards, Angela Heck, Sandra Ackermann, Amanda Aerni, Nathalie Schicktanz, Bianca Auschra, Philippe Demougin, Eva Mumme, Thomas Elbert, Verena Ertl, Leo Gschwind, Edveena Hanser, Kim-Dung Huynh, Frank Jessen, Iris-Tatjana Kolassa, Annette Milnik, Paolo Paganetti, Klara Spalek, Christian Vogler, Andreas Muhs, Andrea Pfeifer, and Dominique J.-F. de Quervain
      PNAS November 12, 2013 110 (46) E4369-E4374; https://doi.org/10.1073/pnas.1314478110
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      Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism
      Daniella Rylander, Vincenza Bagetta, Valentina Pendolino, Elisa Zianni, Shane Grealish, Fabrizio Gardoni, Monica Di Luca, Paolo Calabresi, M. Angela Cenci, and Barbara Picconi
      PNAS November 12, 2013 110 (46) E4375-E4384; https://doi.org/10.1073/pnas.1311187110
    • You have access
      C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
      Christian S. Lobsiger, Severine Boillée, Christine Pozniak, Amir M. Khan, Melissa McAlonis-Downes, Joseph W. Lewcock, and Don W. Cleveland
      PNAS November 12, 2013 110 (46) E4385-E4392; https://doi.org/10.1073/pnas.1318309110

      See companion article:

      • Reply to Woodruff: Role of C1q and C3 in ALS mice
        - Dec 31, 2013
    • You have access
      High-speed laser microsurgery of alert fruit flies for fluorescence imaging of neural activity
      Supriyo Sinha, Liang Liang, Eric T. W. Ho, Karel E. Urbanek, Liqun Luo, Thomas M. Baer, and Mark J. Schnitzer
      PNAS November 12, 2013 110 (46) 18374-18379; https://doi.org/10.1073/pnas.1216287110
    • You have access
      Pheromone discrimination by a pH-tuned polymorphism of the Bombyx mori pheromone-binding protein
      Fred F. Damberger, Erich Michel, Yuko Ishida, Walter S. Leal, and Kurt Wüthrich
      PNAS November 12, 2013 110 (46) 18680-18685; https://doi.org/10.1073/pnas.1317706110
    • You have access
      A universal strategy for visually guided landing
      Emily Baird, Norbert Boeddeker, Michael R. Ibbotson, and Mandyam V. Srinivasan
      PNAS November 12, 2013 110 (46) 18686-18691; https://doi.org/10.1073/pnas.1314311110
    • You have access
      Mind wandering away from pain dynamically engages antinociceptive and default mode brain networks
      Aaron Kucyi, Tim V. Salomons, and Karen D. Davis
      PNAS November 12, 2013 110 (46) 18692-18697; https://doi.org/10.1073/pnas.1312902110
    • You have access
      Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons
      Lynn George, Marta Chaverra, Lindsey Wolfe, Julian Thorne, Mattheson Close-Davis, Amy Eibs, Vickie Riojas, Andrea Grindeland, Miranda Orr, George A. Carlson, and Frances Lefcort
      PNAS November 12, 2013 110 (46) 18698-18703; https://doi.org/10.1073/pnas.1308596110
    • Open Access
      Differential expression of olfactory genes in the southern house mosquito and insights into unique odorant receptor gene isoforms
      Walter S. Leal, Young-Moo Choo, Pingxi Xu, Cherre S. B. da Silva, and Carlos Ueira-Vieira
      PNAS November 12, 2013 110 (46) 18704-18709; https://doi.org/10.1073/pnas.1316059110
  • Physiology

    • You have access
      Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction
      Daniela Wenzel, Michaela Matthey, Laura Bindila, Raissa Lerner, Beat Lutz, Andreas Zimmer, and Bernd K. Fleischmann
      PNAS November 12, 2013 110 (46) 18710-18715; https://doi.org/10.1073/pnas.1308130110
    • You have access
      Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography
      Giovanni Gonzalez-Gutierrez, Luis G. Cuello, Satish K. Nair, and Claudio Grosman
      PNAS November 12, 2013 110 (46) 18716-18721; https://doi.org/10.1073/pnas.1313156110
  • Plant Biology

    • You have access
      The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a
      Jennifer D. Lewis, Amy Huei-Yi Lee, Jana A. Hassan, Janet Wan, Brenden Hurley, Jacquelyn R. Jhingree, Pauline W. Wang, Timothy Lo, Ji-Young Youn, David S. Guttman, and Darrell Desveaux
      PNAS November 12, 2013 110 (46) 18722-18727; https://doi.org/10.1073/pnas.1315520110
  • Psychological and Cognitive Sciences

    • You have access
      Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood
      Pilyoung Kim, Gary W. Evans, Michael Angstadt, S. Shaun Ho, Chandra S. Sripada, James E. Swain, Israel Liberzon, and K. Luan Phan
      PNAS November 12, 2013 110 (46) 18442-18447; https://doi.org/10.1073/pnas.1308240110
    • You have access
      First-person action experience reveals sensitivity to action efficiency in prereaching infants
      Amy E. Skerry, Susan E. Carey, and Elizabeth S. Spelke
      PNAS November 12, 2013 110 (46) 18728-18733; https://doi.org/10.1073/pnas.1312322110
  • Systems Biology

    • Open Access
      Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes
      Patrick A. Gibney, Charles Lu, Amy A. Caudy, David C. Hess, and David Botstein
      PNAS November 12, 2013 110 (46) E4393-E4402; https://doi.org/10.1073/pnas.1318100110

Corrections

  • You have access
    Correction for Kamisetty et al., Assessing the utility of coevolution-based residue-residue contact predictions in a sequence- and structure-rich era
    PNAS November 12, 2013 110 (46) 18734; https://doi.org/10.1073/pnas.1319550110
  • You have access
    Correction for Flores et al., Trafficking of gap junction channels at a vertebrate electrical synapse in vivo
    PNAS November 12, 2013 110 (46) 18735; https://doi.org/10.1073/pnas.1319624110
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Proceedings of the National Academy of Sciences: 110 (46)
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