Table of Contents

Biological Sciences

• Biochemistry

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    Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules

    Roland D. Kersten, Nadine Ziemert, David J. Gonzalez, Brendan M. Duggan, Victor Nizet, Pieter C. Dorrestein, and Bradley S. Moore

    PNAS November 19, 2013 110 (47) E4407-E4416; https://doi.org/10.1073/pnas.1315492110
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    Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate

    Leon Harrington, Stephen Cheley, Leila T. Alexander, Stefan Knapp, and Hagan Bayley

    PNAS November 19, 2013 110 (47) E4417-E4426; https://doi.org/10.1073/pnas.1312739110
  • Open Access

    Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing

    • Inaugural Article

    K. C. Allen Chan, Peiyong Jiang, Carol W. M. Chan, Kun Sun, John Wong, Edwin P. Hui, Stephen L. Chan, Wing Cheong Chan, David S. C. Hui, Simon S. M. Ng, Henry L. Y. Chan, Cesar S. C. Wong, Brigette B. Y. Ma, Anthony T. C. Chan, Paul B. S. Lai, Hao Sun, Rossa W. K. Chiu, and Y. M. Dennis Lo

    PNAS November 19, 2013 110 (47) 18761-18768; https://doi.org/10.1073/pnas.1313995110

    See companion article:

    • Profile of Dennis Lo

      - Oct 21, 2013
  • Open Access

    Rescue of a primary myelofibrosis model by retinoid-antagonist therapy

    Suk-Hyun Hong, Melita Dvorak-Ewell, Hazel Y. Stevens, Grant D. Barish, Glenda L. Castro, Russell Nofsinger, John A. Frangos, Dolores Shoback, and Ronald M. Evans

    PNAS November 19, 2013 110 (47) 18820-18825; https://doi.org/10.1073/pnas.1318974110
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    Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals

    Samarpita Sengupta, Andrés Lorente-Rodríguez, Svetlana Earnest, Steve Stippec, Xiaofeng Guo, David C. Trudgian, Hamid Mirzaei, and Melanie H. Cobb

    PNAS November 19, 2013 110 (47) 18826-18831; https://doi.org/10.1073/pnas.1318676110
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    Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase

    Jie Liu, Resat Cinar, Keming Xiong, Grzegorz Godlewski, Tony Jourdan, Yuhong Lin, James M. Ntambi, and George Kunos

    PNAS November 19, 2013 110 (47) 18832-18837; https://doi.org/10.1073/pnas.1309469110
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    Frontalin pheromone biosynthesis in the mountain pine beetle, Dendroctonus ponderosae, and the role of isoprenyl diphosphate synthases

    Christopher I. Keeling, Christine C. Chiu, Tidiane Aw, Maria Li, Hannah Henderson, Claus Tittiger, Hong-Biao Weng, Gary J. Blomquist, and Joerg Bohlmann

    PNAS November 19, 2013 110 (47) 18838-18843; https://doi.org/10.1073/pnas.1316498110
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    Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12

    Zoltan Metlagel, Chinatsu Otomo, Giichi Takaesu, and Takanori Otomo

    PNAS November 19, 2013 110 (47) 18844-18849; https://doi.org/10.1073/pnas.1314755110
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    DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass

    Giovanni Maga, Emmanuele Crespan, Enni Markkanen, Ralph Imhof, Antonia Furrer, Giuseppe Villani, Ulrich Hübscher, and Barbara van Loon

    PNAS November 19, 2013 110 (47) 18850-18855; https://doi.org/10.1073/pnas.1308760110
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    Functional asymmetry within the Sec61p translocon

    Erhan Demirci, Tina Junne, Sefer Baday, Simon Bernèche, and Martin Spiess

    PNAS November 19, 2013 110 (47) 18856-18861; https://doi.org/10.1073/pnas.1318432110
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    Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

    Oscar Vadas, Hashem A. Dbouk, Aliaksei Shymanets, Olga Perisic, John E. Burke, Widian F. Abi Saab, Bassem D. Khalil, Christian Harteneck, Anne R. Bresnick, Bernd Nürnberg, Jonathan M. Backer, and Roger L. Williams

    PNAS November 19, 2013 110 (47) 18862-18867; https://doi.org/10.1073/pnas.1304801110
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    Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET

    Brian Cannon, Jeffrey Kuhnlein, Soo-Hyun Yang, Anita Cheng, Detlev Schindler, Jeremy M. Stark, Rick Russell, and Tanya T. Paull

    PNAS November 19, 2013 110 (47) 18868-18873; https://doi.org/10.1073/pnas.1309816110
  • Open Access

    Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases

    Bigna Wörsdörfer, Mahesh Lingaraju, Neela H. Yennawar, Amie K. Boal, Carsten Krebs, J. Martin Bollinger Jr., and Maria-Eirini Pandelia

    PNAS November 19, 2013 110 (47) 18874-18879; https://doi.org/10.1073/pnas.1315927110

• Biophysics and Computational Biology

  • Open Access

    Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions

    Zoltan Bozoky, Mickael Krzeminski, Ranjith Muhandiram, James R. Birtley, Ateeq Al-Zahrani, Philip J. Thomas, Raymond A. Frizzell, Robert C. Ford, and Julie D. Forman-Kay

    PNAS November 19, 2013 110 (47) E4427-E4436; https://doi.org/10.1073/pnas.1315104110
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    NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors

    Lukasz Skora, Jürgen Mestan, Doriano Fabbro, Wolfgang Jahnke, and Stephan Grzesiek

    PNAS November 19, 2013 110 (47) E4437-E4445; https://doi.org/10.1073/pnas.1314712110
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    Single-molecule inhibition of human kinesin by adociasulfate-13 and -14 from the sponge Cladocroce aculeata

    Thomas E. Smith, Weili Hong, Malcolm M. Zachariah, Mary Kay Harper, Teatulohi K. Matainaho, Ryan M. Van Wagoner, Chris M. Ireland, and Michael Vershinin

    PNAS November 19, 2013 110 (47) 18880-18885; https://doi.org/10.1073/pnas.1314132110
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    Changing hydration level in an internal cavity modulates the proton affinity of a key glutamate in cytochrome c oxidase

    Puja Goyal, Jianxun Lu, Shuo Yang, M. R. Gunner, and Qiang Cui

    PNAS November 19, 2013 110 (47) 18886-18891; https://doi.org/10.1073/pnas.1313908110
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    Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

    Jae-Won Shin, Kyle R. Spinler, Joe Swift, Joel A. Chasis, Narla Mohandas, and Dennis E. Discher

    PNAS November 19, 2013 110 (47) 18892-18897; https://doi.org/10.1073/pnas.1304996110
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    Folding of a large protein at high structural resolution

    Benjamin T. Walters, Leland Mayne, James R. Hinshaw, Tobin R. Sosnick, and S. Walter Englander

    PNAS November 19, 2013 110 (47) 18898-18903; https://doi.org/10.1073/pnas.1319482110
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    Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA

    Andrew H. Laszlo, Ian M. Derrington, Henry Brinkerhoff, Kyle W. Langford, Ian C. Nova, Jenny Mae Samson, Joshua J. Bartlett, Mikhail Pavlenok, and Jens H. Gundlach

    PNAS November 19, 2013 110 (47) 18904-18909; https://doi.org/10.1073/pnas.1310240110

    See companion article:

    • Nanopore discrimination among C, mC, and hmC

      - Oct 28, 2013
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    Error rates for nanopore discrimination among cytosine, methylcytosine, and hydroxymethylcytosine along individual DNA strands

    Jacob Schreiber, Zachary L. Wescoe, Robin Abu-Shumays, John T. Vivian, Baldandorj Baatar, Kevin Karplus, and Mark Akeson

    PNAS November 19, 2013 110 (47) 18910-18915; https://doi.org/10.1073/pnas.1310615110

    See companion article:

    • Mapping of ^mC and ^hC with nanopore MspA

      - Oct 28, 2013
  • Open Access

    Mechanistic picture for conformational transition of a membrane transporter at atomic resolution

    Mahmoud Moradi and Emad Tajkhorshid

    PNAS November 19, 2013 110 (47) 18916-18921; https://doi.org/10.1073/pnas.1313202110
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    Intracellular ATP binding is required to activate the slowly activating K⁺ channel I_Ks

    Yang Li, Junyuan Gao, Zhongju Lu, Kelli McFarland, Jingyi Shi, Kevin Bock, Ira S. Cohen, and Jianmin Cui

    PNAS November 19, 2013 110 (47) 18922-18927; https://doi.org/10.1073/pnas.1315649110
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    Filopodial retraction force is generated by cortical actin dynamics and controlled by reversible tethering at the tip

    Thomas Bornschlögl, Stéphane Romero, Christian L. Vestergaard, Jean-François Joanny, Guy Tran Van Nhieu, and Patricia Bassereau

    PNAS November 19, 2013 110 (47) 18928-18933; https://doi.org/10.1073/pnas.1316572110

• Cell Biology

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    Cell-cycle regulation of formin-mediated actin cable assembly

    • From the Cover

    Yansong Miao, Catherine C. L. Wong, Vito Mennella, Alphée Michelot, David A. Agard, Liam J. Holt, John R. Yates III, and David G. Drubin

    PNAS November 19, 2013 110 (47) E4446-E4455; https://doi.org/10.1073/pnas.1314000110

    See companion article:

    • In vitro formin-dependent actin cable assembly

      - Oct 31, 2013
  • Open Access

    Assembly factors for the membrane arm of human complex I

    Byron Andrews, Joe Carroll, Shujing Ding, Ian M. Fearnley, and John E. Walker

    PNAS November 19, 2013 110 (47) 18934-18939; https://doi.org/10.1073/pnas.1319247110
  • Open Access

    Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression

    Yasuhiro Yoshimatsu, Yulia G. Lee, Yuichi Akatsu, Luna Taguchi, Hiroshi I. Suzuki, Sara I. Cunha, Kazuichi Maruyama, Yuka Suzuki, Tomoko Yamazaki, Akihiro Katsura, S. Paul Oh, Teresa A. Zimmers, Se-Jin Lee, Kristian Pietras, Gou Young Koh, Kohei Miyazono, and Tetsuro Watabe

    PNAS November 19, 2013 110 (47) 18940-18945; https://doi.org/10.1073/pnas.1310479110

    See companion article:

    • Another fateful role for BMPs

      - Nov 12, 2013
  • Open Access

    MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis

    • From the Cover

    Catalina Perdomo, Joshua D. Campbell, Joseph Gerrein, Carmen S. Tellez, Carly B. Garrison, Tonya C. Walser, Eduard Drizik, Huiqing Si, Adam C. Gower, Jessica Vick, Christina Anderlind, George R. Jackson, Courtney Mankus, Frank Schembri, Carl O’Hara, Brigitte N. Gomperts, Steven M. Dubinett, Patrick Hayden, Steven A. Belinsky, Marc E. Lenburg, and Avrum Spira

    PNAS November 19, 2013 110 (47) 18946-18951; https://doi.org/10.1073/pnas.1220319110

    See companion article:

    • miR-4423 enters the lung cancer landscape

      - Nov 04, 2013
  • Open Access

    TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor

    Maria Victoria Niklison-Chirou, Joern R. Steinert, Massimiliano Agostini, Richard A. Knight, David Dinsdale, Antonio Cattaneo, Tak W. Mak, and Gerry Melino

    PNAS November 19, 2013 110 (47) 18952-18957; https://doi.org/10.1073/pnas.1221172110
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    Self-contact elimination by membrane fusion

    Grant M. Sumida and Soichiro Yamada

    PNAS November 19, 2013 110 (47) 18958-18963; https://doi.org/10.1073/pnas.1311135110
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    ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress

    Masato Mashimo, Jiro Kato, and Joel Moss

    PNAS November 19, 2013 110 (47) 18964-18969; https://doi.org/10.1073/pnas.1312783110
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    Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation

    Adam Burton, Cristina Azevedo, Catia Andreassi, Antonella Riccio, and Adolfo Saiardi

    PNAS November 19, 2013 110 (47) 18970-18975; https://doi.org/10.1073/pnas.1309699110
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    Rab GAP cascade regulates dynamics of Ypt6 in the Golgi traffic

    Yasuyuki Suda, Kazuo Kurokawa, Ryogo Hirata, and Akihiko Nakano

    PNAS November 19, 2013 110 (47) 18976-18981; https://doi.org/10.1073/pnas.1308627110

• Developmental Biology

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    Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

    Briana E. Rockich, Steven M. Hrycaj, Hung Ping Shih, Melinda S. Nagy, Michael A. H. Ferguson, Janel L. Kopp, Maike Sander, Deneen M. Wellik, and Jason R. Spence

    PNAS November 19, 2013 110 (47) E4456-E4464; https://doi.org/10.1073/pnas.1311847110
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    Glycolysis supports embryonic muscle growth by promoting myoblast fusion

    Vanessa Tixier, Laetitia Bataillé, Christelle Etard, Teresa Jagla, Meltem Weger, Jean Philippe DaPonte, Uwe Strähle, Thomas Dickmeis, and Krzysztof Jagla

    PNAS November 19, 2013 110 (47) 18982-18987; https://doi.org/10.1073/pnas.1301262110

• Ecology

  • Open Access

    Sagebrush carrying out hydraulic lift enhances surface soil nitrogen cycling and nitrogen uptake into inflorescences

    Zoe G. Cardon, John M. Stark, Patrick M. Herron, and Jed A. Rasmussen

    PNAS November 19, 2013 110 (47) 18988-18993; https://doi.org/10.1073/pnas.1311314110

• Environmental Sciences

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    Nitrogen isotope effects induced by anammox bacteria

    Benjamin Brunner, Sergio Contreras, Moritz F. Lehmann, Olga Matantseva, Mark Rollog, Tim Kalvelage, Gabriele Klockgether, Gaute Lavik, Mike S. M. Jetten, Boran Kartal, and Marcel M. M. Kuypers

    PNAS November 19, 2013 110 (47) 18994-18999; https://doi.org/10.1073/pnas.1310488110

• Evolution

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    Pulvinar neurons reveal neurobiological evidence of past selection for rapid detection of snakes

    • From the Cover

    Quan Van Le, Lynne A. Isbell, Jumpei Matsumoto, Minh Nguyen, Etsuro Hori, Rafael S. Maior, Carlos Tomaz, Anh Hai Tran, Taketoshi Ono, and Hisao Nishijo

    PNAS November 19, 2013 110 (47) 19000-19005; https://doi.org/10.1073/pnas.1312648110

• Genetics

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    Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat

    Tadas Jakočiūnas, Marie Domange Jordö, Mazhoura Aït Mebarek, Camilla Marie Bünner, Janne Verhein-Hansen, Lene B. Oddershede, and Geneviève Thon

    PNAS November 19, 2013 110 (47) E4465-E4473; https://doi.org/10.1073/pnas.1315581110
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    Drosophila switch gene Sex-lethal can bypass its switch-gene target transformer to regulate aspects of female behavior

    Daniel S. Evans and Thomas W. Cline

    PNAS November 19, 2013 110 (47) E4474-E4481; https://doi.org/10.1073/pnas.1319063110
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    Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging

    David C. Glahn, Jack W. Kent Jr., Emma Sprooten, Vincent P. Diego, Anderson M. Winkler, Joanne E. Curran, D. Reese McKay, Emma E. Knowles, Melanie A Carless, Harald H. H. Göring, Thomas D. Dyer, Rene L. Olvera, Peter T. Fox, Laura Almasy, Jac Charlesworth, Peter Kochunov, Ravi Duggirala, and John Blangero

    PNAS November 19, 2013 110 (47) 19006-19011; https://doi.org/10.1073/pnas.1313735110
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    Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9

    Xingjie Ren, Jin Sun, Benjamin E. Housden, Yanhui Hu, Charles Roesel, Shuailiang Lin, Lu-Ping Liu, Zhihao Yang, Decai Mao, Lingzhu Sun, Qujie Wu, Jun-Yuan Ji, Jianzhong Xi, Stephanie E. Mohr, Jiang Xu, Norbert Perrimon, and Jian-Quan Ni

    PNAS November 19, 2013 110 (47) 19012-19017; https://doi.org/10.1073/pnas.1318481110
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    Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins

    Sanshu Li, Kathryn D. Smith, Jared H. Davis, Patricia B. Gordon, Ronald R. Breaker, and Scott A. Strobel

    PNAS November 19, 2013 110 (47) 19018-19023; https://doi.org/10.1073/pnas.1310439110
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    Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy

    Kelly Hyunju Oh and Hongkyun Kim

    PNAS November 19, 2013 110 (47) 19024-19029; https://doi.org/10.1073/pnas.1308866110

• Immunology

  • Open Access

    Syntaxin binding mechanism and disease-causing mutations in Munc18-2

    Yvonne Hackmann, Stephen C. Graham, Stephan Ehl, Stefan Höning, Kai Lehmberg, Maurizio Aricò, David J. Owen, and Gillian M. Griffiths

    PNAS November 19, 2013 110 (47) E4482-E4491; https://doi.org/10.1073/pnas.1313474110
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    Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA

    Megan H. Orzalli, Sara E. Conwell, Christian Berrios, James A. DeCaprio, and David M. Knipe

    PNAS November 19, 2013 110 (47) E4492-E4501; https://doi.org/10.1073/pnas.1316194110
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    Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells

    Xinli Hu, Hyun Kim, Patrick J. Brennan, Buhm Han, Clare M. Baecher-Allan, Philip L. De Jager, Michael B. Brenner, and Soumya Raychaudhuri

    PNAS November 19, 2013 110 (47) 19030-19035; https://doi.org/10.1073/pnas.1318322110
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    Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain

    Wenji Piao, Lisa W. Ru, Kurt H. Piepenbrink, Eric J. Sundberg, Stefanie N. Vogel, and Vladimir Y. Toshchakov

    PNAS November 19, 2013 110 (47) 19036-19041; https://doi.org/10.1073/pnas.1313575110
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    B cells are critical for autoimmune pathology in Scurfy mice

    Susanne Aschermann, Christian H. K. Lehmann, Sidonia Mihai, Georg Schett, Diana Dudziak, and Falk Nimmerjahn

    PNAS November 19, 2013 110 (47) 19042-19047; https://doi.org/10.1073/pnas.1313547110

• Medical Sciences

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    Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease

    • From the Cover

    Tammie L. S. Benzinger, Tyler Blazey, Clifford R. Jack Jr., Robert A. Koeppe, Yi Su, Chengjie Xiong, Marcus E. Raichle, Abraham Z. Snyder, Beau M. Ances, Randall J. Bateman, Nigel J. Cairns, Anne M. Fagan, Alison Goate, Daniel S. Marcus, Paul S. Aisen, Jon J. Christensen, Lindsay Ercole, Russ C. Hornbeck, Angela M. Farrar, Patricia Aldea, Mateusz S. Jasielec, Christopher J. Owen, Xianyun Xie, Richard Mayeux, Adam Brickman, Eric McDade, William Klunk, Chester A. Mathis, John Ringman, Paul M. Thompson, Bernardino Ghetti, Andrew J. Saykin, Reisa A. Sperling, Keith A. Johnson, Stephen Salloway, Stephen Correia, Peter R. Schofield, Colin L. Masters, Christopher Rowe, Victor L. Villemagne, Ralph Martins, Sebastien Ourselin, Martin N. Rossor, Nick C. Fox, David M. Cash, Michael W. Weiner, David M. Holtzman, Virginia D. Buckles, Krista Moulder, and John C. Morris

    PNAS November 19, 2013 110 (47) E4502-E4509; https://doi.org/10.1073/pnas.1317918110
  • Open Access

    Photoswitchable nanoparticles for in vivo cancer chemotherapy

    Rong Tong, Homer H. Chiang, and Daniel S. Kohane

    PNAS November 19, 2013 110 (47) 19048-19053; https://doi.org/10.1073/pnas.1315336110
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    Transplantation of human islets without immunosuppression

    Barbara Ludwig, Andreas Reichel, Anja Steffen, Baruch Zimerman, Andrew V. Schally, Norman L. Block, Clark K. Colton, Stefan Ludwig, Stephan Kersting, Ezio Bonifacio, Michele Solimena, Zohar Gendler, Avi Rotem, Uriel Barkai, and Stefan R. Bornstein

    PNAS November 19, 2013 110 (47) 19054-19058; https://doi.org/10.1073/pnas.1317561110
  • Open Access

    Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation

    Tracy T. Batchelor, Elizabeth R. Gerstner, Kyrre E. Emblem, Dan G. Duda, Jayashree Kalpathy-Cramer, Matija Snuderl, Marek Ancukiewicz, Pavlina Polaskova, Marco C. Pinho, Dominique Jennings, Scott R. Plotkin, Andrew S. Chi, April F. Eichler, Jorg Dietrich, Fred H. Hochberg, Christine Lu-Emerson, A. John Iafrate, S. Percy Ivy, Bruce R. Rosen, Jay S. Loeffler, Patrick Y. Wen, A. Greg Sorensen, and Rakesh K. Jain

    PNAS November 19, 2013 110 (47) 19059-19064; https://doi.org/10.1073/pnas.1318022110
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    Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention

    Hua Liu and Paul Talalay

    PNAS November 19, 2013 110 (47) 19065-19070; https://doi.org/10.1073/pnas.1318247110
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    Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency

    Yucheng Yao, Jiayi Yao, Melina Radparvar, Ana M. Blazquez-Medela, Pierre J. Guihard, Medet Jumabay, and Kristina I. Boström

    PNAS November 19, 2013 110 (47) 19071-19076; https://doi.org/10.1073/pnas.1310905110

• Microbiology

  • Open Access

    Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X

    Francesca Micoli, Maria Rosaria Romano, Marta Tontini, Emilia Cappelletti, Massimiliano Gavini, Daniela Proietti, Simona Rondini, Erwin Swennen, Laura Santini, Sara Filippini, Cristiana Balocchi, Roberto Adamo, Gerd Pluschke, Gunnstein Norheim, Andrew Pollard, Allan Saul, Rino Rappuoli, Calman A. MacLennan, Francesco Berti, and Paolo Costantino

    PNAS November 19, 2013 110 (47) 19077-19082; https://doi.org/10.1073/pnas.1314476110
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    MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells

    Shufeng Liu, Chao Qiu, Ruidong Miao, Jianhua Zhou, Aram Lee, Baoming Liu, Sandra N. Lester, Weihui Fu, Lingyan Zhu, Linxia Zhang, Jianqing Xu, Daping Fan, Kui Li, Mingui Fu, and Tianyi Wang

    PNAS November 19, 2013 110 (47) 19083-19088; https://doi.org/10.1073/pnas.1316208110
  • Open Access

    Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin

    Dagmara I. Kisiela, Victoria B. Rodriguez, Veronika Tchesnokova, Hovhannes Avagyan, Pavel Aprikian, Yan Liu, Xue-Ru Wu, Wendy E. Thomas, and Evgeni V. Sokurenko

    PNAS November 19, 2013 110 (47) 19089-19094; https://doi.org/10.1073/pnas.1314395110
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    A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

    Jee-Hyun Kim, Kathryn M. O’Brien, Ritu Sharma, Helena I. M. Boshoff, German Rehren, Sumit Chakraborty, Joshua B. Wallach, Mercedes Monteleone, Daniel J. Wilson, Courtney C. Aldrich, Clifton E. Barry III, Kyu Y. Rhee, Sabine Ehrt, and Dirk Schnappinger

    PNAS November 19, 2013 110 (47) 19095-19100; https://doi.org/10.1073/pnas.1315860110

• Neuroscience

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    Long-term depression triggers the selective elimination of weakly integrated synapses

    J. Simon Wiegert and Thomas G. Oertner

    PNAS November 19, 2013 110 (47) E4510-E4519; https://doi.org/10.1073/pnas.1315926110
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    CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells

    Kun Do Rhee, Steven Nusinowitz, Kevin Chao, Fei Yu, Dean Bok, and Xian-Jie Yang

    PNAS November 19, 2013 110 (47) E4520-E4529; https://doi.org/10.1073/pnas.1303604110
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    Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

    Clotilde Lagier-Tourenne, Michael Baughn, Frank Rigo, Shuying Sun, Patrick Liu, Hai-Ri Li, Jie Jiang, Andrew T. Watt, Seung Chun, Melanie Katz, Jinsong Qiu, Ying Sun, Shuo-Chien Ling, Qiang Zhu, Magdalini Polymenidou, Kevin Drenner, Jonathan W. Artates, Melissa McAlonis-Downes, Sebastian Markmiller, Kasey R. Hutt, Donald P. Pizzo, Janet Cady, Matthew B. Harms, Robert H. Baloh, Scott R. Vandenberg, Gene W. Yeo, Xiang-Dong Fu, C. Frank Bennett, Don W. Cleveland, and John Ravits

    PNAS November 19, 2013 110 (47) E4530-E4539; https://doi.org/10.1073/pnas.1318835110
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    Long-term inhibitory plasticity in visual cortical layer 4 switches sign at the opening of the critical period

    Sandrine Lefort, Annette C. Gray, and Gina G. Turrigiano

    PNAS November 19, 2013 110 (47) E4540-E4547; https://doi.org/10.1073/pnas.1319571110
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    Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2

    Sven Loebrich, Biljana Djukic, Zachary J. Tong, Jeffrey R. Cottrell, Gina G. Turrigiano, and Elly Nedivi

    PNAS November 19, 2013 110 (47) E4548-E4556; https://doi.org/10.1073/pnas.1318860110
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    Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via G_αs/G_αq-mediated protein kinases A/C

    Daesung Shin, Shu-Ting Lin, Ying-Hui Fu, and Louis J. Ptáček

    PNAS November 19, 2013 110 (47) 19101-19106; https://doi.org/10.1073/pnas.1318501110
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    Epileptic baboons have lower numbers of neurons in specific areas of cortex

    Nicole A. Young, C. Ákos Szabó, Clyde F. Phelix, David K. Flaherty, Pooja Balaram, Kallie B. Foust-Yeoman, Christine E. Collins, and Jon H. Kaas

    PNAS November 19, 2013 110 (47) 19107-19112; https://doi.org/10.1073/pnas.1318894110
  • Open Access

    Cellular organization of cortical barrel columns is whisker-specific

    Hanno S. Meyer, Robert Egger, Jason M. Guest, Rita Foerster, Stefan Reissl, and Marcel Oberlaender

    PNAS November 19, 2013 110 (47) 19113-19118; https://doi.org/10.1073/pnas.1312691110
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    Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence

    Ryan J. Herringa, Rasmus M. Birn, Paula L. Ruttle, Cory A. Burghy, Diane E. Stodola, Richard J. Davidson, and Marilyn J. Essex

    PNAS November 19, 2013 110 (47) 19119-19124; https://doi.org/10.1073/pnas.1310766110
  • Open Access

    Estrogen receptor (ER) β expression in oligodendrocytes is required for attenuation of clinical disease by an ERβ ligand

    Anna J. Khalaj, JaeHee Yoon, Jaspreet Nakai, Zachary Winchester, Spencer M. Moore, Timothy Yoo, Leonardo Martinez-Torres, Shalini Kumar, Noriko Itoh, and Seema Kaushalya Tiwari-Woodruff

    PNAS November 19, 2013 110 (47) 19125-19130; https://doi.org/10.1073/pnas.1311763110
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    X-linked microtubule-associated protein, Mid1, regulates axon development

    Tingjia Lu, Renchao Chen, Timothy C. Cox, Randal X. Moldrich, Nyoman Kurniawan, Guohe Tan, Jo K. Perry, Alan Ashworth, Perry F. Bartlett, Li Xu, Jing Zhang, Bin Lu, Mingyue Wu, Qi Shen, Yuanyuan Liu, Linda J. Richards, and Zhiqi Xiong

    PNAS November 19, 2013 110 (47) 19131-19136; https://doi.org/10.1073/pnas.1303687110
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    Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro

    Jing Wang and Robert K. Yu

    PNAS November 19, 2013 110 (47) 19137-19142; https://doi.org/10.1073/pnas.1307224110

• Pharmacology

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    Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)

    Shujuan Chen, Mei-Fei Yueh, Cyril Bigo, Olivier Barbier, Kepeng Wang, Michael Karin, Nghia Nguyen, and Robert H. Tukey

    PNAS November 19, 2013 110 (47) 19143-19148; https://doi.org/10.1073/pnas.1319123110

• Plant Biology

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    Phytoplasmal infection derails genetically preprogrammed meristem fate and alters plant architecture

    Wei Wei, Robert Edward Davis, Donald L. Nuss, and Yan Zhao

    PNAS November 19, 2013 110 (47) 19149-19154; https://doi.org/10.1073/pnas.1318489110

• Physiology

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    Functional identification and characterization of sodium binding sites in Na symporters

    Donald D. F. Loo, Xuan Jiang, Edurne Gorraitz, Bruce A. Hirayama, and Ernest M. Wright

    PNAS November 19, 2013 110 (47) E4557-E4566; https://doi.org/10.1073/pnas.1319218110

• Psychological and Cognitive Sciences

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    Honey bees selectively avoid difficult choices

    Clint J. Perry and Andrew B. Barron

    PNAS November 19, 2013 110 (47) 19155-19159; https://doi.org/10.1073/pnas.1314571110

• Systems Biology

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    miRNA and mRNA cancer signatures determined by analysis of expression levels in large cohorts of patients

    • From the Cover

    Sohila Zadran, F. Remacle, and R. D. Levine

    PNAS November 19, 2013 110 (47) 19160-19165; https://doi.org/10.1073/pnas.1316991110

    See companion article:

    • Thermodynamic classifier for molecular phenotypes

      - Nov 07, 2013
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    Computational evaluation of cellular metabolic costs successfully predicts genes whose expression is deleterious

    Allon Wagner, Raphy Zarecki, Leah Reshef, Camelia Gochev, Rotem Sorek, Uri Gophna, and Eytan Ruppin

    PNAS November 19, 2013 110 (47) 19166-19171; https://doi.org/10.1073/pnas.1312361110