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Biological Sciences

• Agricultural Sciences

  • Open Access

    Host-induced gene silencing of cytochrome P450 lanosterol C14α-demethylase–encoding genes confers strong resistance to Fusarium species

    Aline Koch, Neelendra Kumar, Lennart Weber, Harald Keller, Jafargholi Imani, and Karl-Heinz Kogel

    PNAS November 26, 2013 110 (48) 19324-19329; https://doi.org/10.1073/pnas.1306373110

• Applied Biological Sciences

  • Open Access

    Antibody biomarker discovery through in vitro directed evolution of consensus recognition epitopes

    John T. Ballew, Joseph A. Murray, Pekka Collin, Markku Mäki, Martin F. Kagnoff, Katri Kaukinen, and Patrick S. Daugherty

    PNAS November 26, 2013 110 (48) 19330-19335; https://doi.org/10.1073/pnas.1314792110
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    Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway

    Huan Wang, Mark W. Tibbitt, Stephen J. Langer, Leslie A. Leinwand, and Kristi S. Anseth

    PNAS November 26, 2013 110 (48) 19336-19341; https://doi.org/10.1073/pnas.1306369110

• Biochemistry

  • Open Access

    Structural and genetic analyses reveal the protein SepF as a new membrane anchor for the Z ring

    Ramona Duman, Shu Ishikawa, Ilkay Celik, Henrik Strahl, Naotake Ogasawara, Paulina Troc, Jan Löwe, and Leendert W. Hamoen

    PNAS November 26, 2013 110 (48) E4601-E4610; https://doi.org/10.1073/pnas.1313978110
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    Crystal structure of the human eIF4AIII–CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain

    Gretel Buchwald, Steffen Schüssler, Claire Basquin, Hervé Le Hir, and Elena Conti

    PNAS November 26, 2013 110 (48) E4611-E4618; https://doi.org/10.1073/pnas.1314684110
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    Impact of reconstituted cytosol on protein stability

    Mohona Sarkar, Austin E. Smith, and Gary J. Pielak

    PNAS November 26, 2013 110 (48) 19342-19347; https://doi.org/10.1073/pnas.1312678110
  • Open Access

    Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy

    Zhenxi Zhang, Anna Maria Pinto, Lili Wan, Wei Wang, Michael G. Berg, Isabela Oliva, Larry N. Singh, Christopher Dengler, Zhi Wei, and Gideon Dreyfuss

    PNAS November 26, 2013 110 (48) 19348-19353; https://doi.org/10.1073/pnas.1319280110
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    Purified TMEM16A is sufficient to form Ca²⁺-activated Cl⁻ channels

    • From the Cover

    Hiroyuki Terashima, Alessandra Picollo, and Alessio Accardi

    PNAS November 26, 2013 110 (48) 19354-19359; https://doi.org/10.1073/pnas.1312014110

    See companion article:

    • Functional reconstitution of a chloride channel

      - Nov 14, 2013
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    Structural and functional insights into the regulation mechanism of CK2 by IP₆ and the intrinsically disordered protein Nopp140

    Won-Kyu Lee, Sang Hyeon Son, Bong-Suk Jin, Jung-Hyun Na, Soo-Youl Kim, Kook-Han Kim, Eunice EunKyeong Kim, Yeon Gyu Yu, and Hyung Ho Lee

    PNAS November 26, 2013 110 (48) 19360-19365; https://doi.org/10.1073/pnas.1304670110
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    Metabolically programmed quality control system for dolichol-linked oligosaccharides

    Yoichiro Harada, Kazuki Nakajima, Yuki Masahara-Negishi, Hudson H. Freeze, Takashi Angata, Naoyuki Taniguchi, and Tadashi Suzuki

    PNAS November 26, 2013 110 (48) 19366-19371; https://doi.org/10.1073/pnas.1312187110

• Biophysics and Computational Biology

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    Quantifying the dynamic interactions between a clathrin-coated pit and cargo molecules

    Aubrey V. Weigel, Michael M. Tamkun, and Diego Krapf

    PNAS November 26, 2013 110 (48) E4591-E4600; https://doi.org/10.1073/pnas.1315202110
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    Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

    Jihye Seong, Arash Tajik, Jie Sun, Jun-Lin Guan, Martin J. Humphries, Susan E. Craig, Asha Shekaran, Andrés J. García, Shaoying Lu, Michael Z. Lin, Ning Wang, and Yingxiao Wang

    PNAS November 26, 2013 110 (48) 19372-19377; https://doi.org/10.1073/pnas.1307405110
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    Detection of single photons by toad and mouse rods

    Jürgen Reingruber, Johan Pahlberg, Michael L. Woodruff, Alapakkam P. Sampath, Gordon L. Fain, and David Holcman

    PNAS November 26, 2013 110 (48) 19378-19383; https://doi.org/10.1073/pnas.1314030110
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    Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate

    Binyong Liang, Volker Kiessling, and Lukas K. Tamm

    PNAS November 26, 2013 110 (48) 19384-19389; https://doi.org/10.1073/pnas.1314699110
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    Structural insights into the histone H1-nucleosome complex

    Bing-Rui Zhou, Hanqiao Feng, Hidenori Kato, Liang Dai, Yuedong Yang, Yaoqi Zhou, and Yawen Bai

    PNAS November 26, 2013 110 (48) 19390-19395; https://doi.org/10.1073/pnas.1314905110
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    Single-molecule resolution of protein structure and interfacial dynamics on biomaterial surfaces

    Sean Yu McLoughlin, Mark Kastantin, Daniel K. Schwartz, and Joel L. Kaar

    PNAS November 26, 2013 110 (48) 19396-19401; https://doi.org/10.1073/pnas.1311761110

• Cell Biology

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    Emergence of spatial structure in the tumor microenvironment due to the Warburg effect

    Carlos Carmona-Fontaine, Vanni Bucci, Leila Akkari, Maxime Deforet, Johanna A. Joyce, and Joao B. Xavier

    PNAS November 26, 2013 110 (48) 19402-19407; https://doi.org/10.1073/pnas.1311939110
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    Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

    Jaakko L. O. Pohjoismäki, Siôn L. Williams, Thomas Boettger, Steffi Goffart, Johnny Kim, Anu Suomalainen, Carlos T. Moraes, and Thomas Braun

    PNAS November 26, 2013 110 (48) 19408-19413; https://doi.org/10.1073/pnas.1303046110
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    Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer

    Soo J. Shin, Jeffrey A. Smith, Günther A. Rezniczek, Sheng Pan, Ru Chen, Teresa A. Brentnall, Gerhard Wiche, and Kimberly A. Kelly

    PNAS November 26, 2013 110 (48) 19414-19419; https://doi.org/10.1073/pnas.1309720110
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    Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy

    Mica Ohara-Imaizumi, Hail Kim, Masashi Yoshida, Tomonori Fujiwara, Kyota Aoyagi, Yukiko Toyofuku, Yoko Nakamichi, Chiyono Nishiwaki, Tadashi Okamura, Toyoyoshi Uchida, Yoshio Fujitani, Kimio Akagawa, Masafumi Kakei, Hirotaka Watada, Michael S. German, and Shinya Nagamatsu

    PNAS November 26, 2013 110 (48) 19420-19425; https://doi.org/10.1073/pnas.1310953110
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    Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition

    Donald S. Kirkpatrick, Daisy J. Bustos, Taner Dogan, Jocelyn Chan, Lilian Phu, Amy Young, Lori S. Friedman, Marcia Belvin, Qinghua Song, Corey E. Bakalarski, and Klaus P. Hoeflich

    PNAS November 26, 2013 110 (48) 19426-19431; https://doi.org/10.1073/pnas.1309473110
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    The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway

    Dongyan Tan, Yiying Cai, Juan Wang, Jinzhong Zhang, Shekar Menon, Hui-Ting Chou, Susan Ferro-Novick, Karin M. Reinisch, and Thomas Walz

    PNAS November 26, 2013 110 (48) 19432-19437; https://doi.org/10.1073/pnas.1316356110

• Developmental Biology

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    Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb

    Ben Xu, Steven M. Hrycaj, Daniel C. McIntyre, Nicholas C. Baker, Jun K. Takeuchi, Lucie Jeannotte, Zachary B. Gaber, Bennett G. Novitch, and Deneen M. Wellik

    PNAS November 26, 2013 110 (48) 19438-19443; https://doi.org/10.1073/pnas.1315075110
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    Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways

    Elizabeth A. Hines, Mary-Kayt N. Jones, Jamie M. Verheyden, Julie F. Harvey, and Xin Sun

    PNAS November 26, 2013 110 (48) 19444-19449; https://doi.org/10.1073/pnas.1313223110
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    Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation

    Lick Pui Lai, Brendan N. Lilley, Joshua R. Sanes, and Andrew P. McMahon

    PNAS November 26, 2013 110 (48) 19450-19455; https://doi.org/10.1073/pnas.1309001110

• Ecology

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    Global meta-analysis reveals no net change in local-scale plant biodiversity over time

    • From the Cover

    Mark Vellend, Lander Baeten, Isla H. Myers-Smith, Sarah C. Elmendorf, Robin Beauséjour, Carissa D. Brown, Pieter De Frenne, Kris Verheyen, and Sonja Wipf

    PNAS November 26, 2013 110 (48) 19456-19459; https://doi.org/10.1073/pnas.1312779110

    See companion article:

    • Biodiversity crisis?

      - Nov 18, 2013

• Evolution

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    Gene amplification and microsatellite polymorphism underlie a recent insect host shift

    Chris Bass, Christoph T. Zimmer, Jacob M. Riveron, Craig S. Wilding, Charles S. Wondji, Martin Kaussmann, Linda M. Field, Martin S. Williamson, and Ralf Nauen

    PNAS November 26, 2013 110 (48) 19460-19465; https://doi.org/10.1073/pnas.1314122110

• Genetics

  • Open Access

    Intrinsic karyotype stability and gene copy number variations may have laid the foundation for tetraploid wheat formation

    Huakun Zhang, Yao Bian, Xiaowan Gou, Yuzhu Dong, Sachin Rustgi, Bangjiao Zhang, Chunming Xu, Ning Li, Bao Qi, Fangpu Han, Diter von Wettstein, and Bao Liu

    PNAS November 26, 2013 110 (48) 19466-19471; https://doi.org/10.1073/pnas.1319598110
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    Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH

    Maria Suntsova, Elena V. Gogvadze, Sergey Salozhin, Nurshat Gaifullin, Fedor Eroshkin, Sergey E. Dmitriev, Natalia Martynova, Kirill Kulikov, Galina Malakhova, Gulnur Tukhbatova, Alexey P. Bolshakov, Dmitry Ghilarov, Andrew Garazha, Alexander Aliper, Charles R. Cantor, Yuri Solokhin, Sergey Roumiantsev, Pavel Balaban, Alex Zhavoronkov, and Anton Buzdin

    PNAS November 26, 2013 110 (48) 19472-19477; https://doi.org/10.1073/pnas.1318172110
  • Open Access

    Fine-scale variation in meiotic recombination in Mimulus inferred from population shotgun sequencing

    Uffe Hellsten, Kevin M. Wright, Jerry Jenkins, Shengqiang Shu, Yaowu Yuan, Susan R. Wessler, Jeremy Schmutz, John H. Willis, and Daniel S. Rokhsar

    PNAS November 26, 2013 110 (48) 19478-19482; https://doi.org/10.1073/pnas.1319032110
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    Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons

    Christiane Kuschal, John. J. DiGiovanna, Sikandar G. Khan, Richard A. Gatti, and Kenneth H. Kraemer

    PNAS November 26, 2013 110 (48) 19483-19488; https://doi.org/10.1073/pnas.1312088110
  • Open Access

    Synthetic lethality between CCNE1 amplification and loss of BRCA1

    Dariush Etemadmoghadam, Barbara A. Weir, George Au-Yeung, Kathryn Alsop, Gillian Mitchell, Joshy George, Australian Ovarian Cancer Study Group, Sally Davis, Alan D. D’Andrea, Kaylene Simpson, William C. Hahn, and David D. L. Bowtell

    PNAS November 26, 2013 110 (48) 19489-19494; https://doi.org/10.1073/pnas.1314302110
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    Genetic variants related to gap junctions and hormone secretion influence conception rates in cows

    Mayumi Sugimoto, Shinji Sasaki, Yusaku Gotoh, Yuuki Nakamura, Yoshito Aoyagi, Takayoshi Kawahara, and Yoshikazu Sugimoto

    PNAS November 26, 2013 110 (48) 19495-19500; https://doi.org/10.1073/pnas.1309307110

• Immunology

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    IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

    • From the Cover

    Martin R. Jakobsen, Rasmus O. Bak, Annika Andersen, Randi K. Berg, Søren B. Jensen, Tengchuan Jin, Anders Laustsen, Kathrine Hansen, Lars Østergaard, Katherine A. Fitzgerald, T. Sam Xiao, Jacob G. Mikkelsen, Trine H. Mogensen, and Søren R. Paludan

    PNAS November 26, 2013 110 (48) E4571-E4580; https://doi.org/10.1073/pnas.1311669110

    See companion article:

    • HIV provides ample PAMPs

      - Nov 13, 2013
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    Growth hormone prevents the development of autoimmune diabetes

    Ricardo Villares, Dimitri Kakabadse, Yasmina Juarranz, Rosa P. Gomariz, Carlos Martínez-A, and Mario Mellado

    PNAS November 26, 2013 110 (48) E4619-E4627; https://doi.org/10.1073/pnas.1314985110
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    Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2

    Elizabeth A. W. Chan, Grace Teng, Elizabeth Corbett, Kingshuk Roy Choudhury, Craig H. Bassing, David G. Schatz, and Michael S. Krangel

    PNAS November 26, 2013 110 (48) E4628-E4637; https://doi.org/10.1073/pnas.1310846110
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    Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo

    Fubin Li and Jeffrey V. Ravetch

    PNAS November 26, 2013 110 (48) 19501-19506; https://doi.org/10.1073/pnas.1319502110

• Medical Sciences

  • Open Access

    Bioavailable copper modulates oxidative phosphorylation and growth of tumors

    Seiko Ishida, Pénélope Andreux, Carole Poitry-Yamate, Johan Auwerx, and Douglas Hanahan

    PNAS November 26, 2013 110 (48) 19507-19512; https://doi.org/10.1073/pnas.1318431110
  • Open Access

    Mouse model of intrahepatic cholangiocarcinoma validates FIG–ROS as a potent fusion oncogene and therapeutic target

    Anna Saborowski, Michael Saborowski, Monika A. Davare, Brian J. Druker, David S. Klimstra, and Scott W. Lowe

    PNAS November 26, 2013 110 (48) 19513-19518; https://doi.org/10.1073/pnas.1311707110

    See companion article:

    • Foretinib is a potent ROS1 inhibitor

      - Nov 11, 2013
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    Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

    Monika A. Davare, Anna Saborowski, Christopher A. Eide, Cristina Tognon, Rebecca L. Smith, Johannes Elferich, Anupriya Agarwal, Jeffrey W. Tyner, Ujwal P. Shinde, Scott W. Lowe, and Brian J. Druker

    PNAS November 26, 2013 110 (48) 19519-19524; https://doi.org/10.1073/pnas.1319583110

    See companion article:

    • FIG–ROS is a promising therapeutic target in ICC

      - Oct 23, 2013
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    CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome

    Vincent J. Guen, Carly Gamble, Marc Flajolet, Sheila Unger, Aurélie Thollet, Yoan Ferandin, Andrea Superti-Furga, Pascale A. Cohen, Laurent Meijer, and Pierre Colas

    PNAS November 26, 2013 110 (48) 19525-19530; https://doi.org/10.1073/pnas.1306814110
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    TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection

    Lígia Antunes Gonçalves, Lurdes Rodrigues-Duarte, Joana Rodo, Luciana Vieira de Moraes, Isabel Marques, and Carlos Penha-Gonçalves

    PNAS November 26, 2013 110 (48) 19531-19536; https://doi.org/10.1073/pnas.1306873110
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    Keratin 16 regulates innate immunity in response to epidermal barrier breach

    Juliane C. Lessard, Sylvia Piña-Paz, Jeremy D. Rotty, Robyn P. Hickerson, Roger L. Kaspar, Allan Balmain, and Pierre A. Coulombe

    PNAS November 26, 2013 110 (48) 19537-19542; https://doi.org/10.1073/pnas.1309576110

• Microbiology

  • Open Access

    Structure and assembly of an inner membrane platform for initiation of type IV pilus biogenesis

    Vijaykumar Karuppiah, Richard F. Collins, Angela Thistlethwaite, Ya Gao, and Jeremy P. Derrick

    PNAS November 26, 2013 110 (48) E4638-E4647; https://doi.org/10.1073/pnas.1312313110
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    Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network

    Lars Plate and Michael A. Marletta

    PNAS November 26, 2013 110 (48) E4648-E4657; https://doi.org/10.1073/pnas.1318128110
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    Global methylation state at base-pair resolution of the Caulobacter genome throughout the cell cycle

    Jennifer B. Kozdon, Michael D. Melfi, Khai Luong, Tyson A. Clark, Matthew Boitano, Susana Wang, Bo Zhou, Diego Gonzalez, Justine Collier, Stephen W. Turner, Jonas Korlach, Lucy Shapiro, and Harley H. McAdams

    PNAS November 26, 2013 110 (48) E4658-E4667; https://doi.org/10.1073/pnas.1319315110
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    Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein

    Jessica S. Schneider, Shilpa P. Reddy, Hock Y. E, Henry W. Evans, and Michael S. Glickman

    PNAS November 26, 2013 110 (48) 19543-19548; https://doi.org/10.1073/pnas.1305934110
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    Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division

    Ruth Kiro, Shahar Molshanski-Mor, Ido Yosef, Sara L. Milam, Harold P. Erickson, and Udi Qimron

    PNAS November 26, 2013 110 (48) 19549-19554; https://doi.org/10.1073/pnas.1314096110

• Neuroscience

  • Open Access

    Dynamic faces speed up the onset of auditory cortical spiking responses during vocal detection

    Chandramouli Chandrasekaran, Luis Lemus, and Asif A. Ghazanfar

    PNAS November 26, 2013 110 (48) E4668-E4677; https://doi.org/10.1073/pnas.1312518110
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    Rapid stimulus-evoked astrocyte Ca²⁺ elevations and hemodynamic responses in mouse somatosensory cortex in vivo

    Barbara Lykke Lind, Alexey R. Brazhe, Sanne Barsballe Jessen, Florence C. C. Tan, and Martin J. Lauritzen

    PNAS November 26, 2013 110 (48) E4678-E4687; https://doi.org/10.1073/pnas.1310065110
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    Transmission of multiple system atrophy prions to transgenic mice

    Joel C. Watts, Kurt Giles, Abby Oehler, Lefkos Middleton, David T. Dexter, Steve M. Gentleman, Stephen J. DeArmond, and Stanley B. Prusiner

    PNAS November 26, 2013 110 (48) 19555-19560; https://doi.org/10.1073/pnas.1318268110
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    Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

    Arati A. Inamdar, Muhammad M. Hossain, Alison I. Bernstein, Gary W. Miller, Jason R. Richardson, and Joan Wennstrom Bennett

    PNAS November 26, 2013 110 (48) 19561-19566; https://doi.org/10.1073/pnas.1318830110
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    BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer’s disease

    Rebecca M. Burke, Timothy A. Norman, Tarik F. Haydar, Barbara E. Slack, Susan E. Leeman, Jan Krzysztof Blusztajn, and Tiffany J. Mellott

    PNAS November 26, 2013 110 (48) 19567-19572; https://doi.org/10.1073/pnas.1319297110
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    Differential effects of global versus local testosterone on singing behavior and its underlying neural substrate

    Beau A. Alward, Jacques Balthazart, and Gregory F. Ball

    PNAS November 26, 2013 110 (48) 19573-19578; https://doi.org/10.1073/pnas.1311371110
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    High-affinity olfactory receptor for the death-associated odor cadaverine

    Ashiq Hussain, Luis R. Saraiva, David M. Ferrero, Gaurav Ahuja, Venkatesh S. Krishna, Stephen D. Liberles, and Sigrun I. Korsching

    PNAS November 26, 2013 110 (48) 19579-19584; https://doi.org/10.1073/pnas.1318596110
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    Frequency-specific mechanism links human brain networks for spatial attention

    Amy L. Daitch, Mohit Sharma, Jarod L. Roland, Serguei V. Astafiev, David T. Bundy, Charles M. Gaona, Abraham Z. Snyder, Gordon L. Shulman, Eric C. Leuthardt, and Maurizio Corbetta

    PNAS November 26, 2013 110 (48) 19585-19590; https://doi.org/10.1073/pnas.1307947110
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    Persistence of hippocampal multivoxel patterns into postencoding rest is related to memory

    Arielle Tambini and Lila Davachi

    PNAS November 26, 2013 110 (48) 19591-19596; https://doi.org/10.1073/pnas.1308499110
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    Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans

    Oliver G. Bosch, Julia S. Rihm, Milan Scheidegger, Hans-Peter Landolt, Philipp Stämpfli, Janis Brakowski, Fabrizio Esposito, Björn Rasch, and Erich Seifritz

    PNAS November 26, 2013 110 (48) 19597-19602; https://doi.org/10.1073/pnas.1317010110
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    ErbB4 reduces synaptic GABA_A currents independent of its receptor tyrosine kinase activity

    Robert M. Mitchell, Megan J. Janssen, Irina Karavanova, Detlef Vullhorst, Katrina Furth, Anthony Makusky, Sanford P. Markey, and Andres Buonanno

    PNAS November 26, 2013 110 (48) 19603-19608; https://doi.org/10.1073/pnas.1312791110
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    Serotonin selectively enhances perception and sensory neural responses to stimuli generated by same-sex conspecifics

    Tara Deemyad, Michael G. Metzen, Yingzhou Pan, and Maurice J. Chacron

    PNAS November 26, 2013 110 (48) 19609-19614; https://doi.org/10.1073/pnas.1314008110

• Pharmacology

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    Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

    Bin Gong, Thomas Shelite, Fang C. Mei, Tuha Ha, Yaohua Hu, Guang Xu, Qing Chang, Maki Wakamiya, Thomas G. Ksiazek, Paul J. Boor, Donald H. Bouyer, Vsevolod L. Popov, Ju Chen, David H. Walker, and Xiaodong Cheng

    PNAS November 26, 2013 110 (48) 19615-19620; https://doi.org/10.1073/pnas.1314400110

• Physiology

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    Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response

    Ying Fu, Ruth E. Westenbroek, Todd Scheuer, and William A. Catterall

    PNAS November 26, 2013 110 (48) 19621-19626; https://doi.org/10.1073/pnas.1319421110

• Plant Biology

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    Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by interacting with each other via the PPC/DUF296 domain

    Jianfei Zhao, David S. Favero, Hao Peng, and Michael M. Neff

    PNAS November 26, 2013 110 (48) E4688-E4697; https://doi.org/10.1073/pnas.1219277110
  • Open Access

    GmNAC30 and GmNAC81 integrate the endoplasmic reticulum stress- and osmotic stress-induced cell death responses through a vacuolar processing enzyme

    Giselle C. Mendes, Pedro A. B. Reis, Iara P. Calil, Humberto H. Carvalho, Francisco J. L. Aragão, and Elizabeth P. B. Fontes

    PNAS November 26, 2013 110 (48) 19627-19632; https://doi.org/10.1073/pnas.1311729110

    See companion article:

    • Players in the plant unfolded response

      - Nov 13, 2013
  • Open Access

    Protein kinase and ribonuclease domains of IRE1 confer stress tolerance, vegetative growth, and reproductive development in Arabidopsis

    Yan Deng, Renu Srivastava, and Stephen H. Howell

    PNAS November 26, 2013 110 (48) 19633-19638; https://doi.org/10.1073/pnas.1314749110

    See companion article:

    • Players in the plant unfolded response

      - Nov 13, 2013
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    Comprehensive analysis of imprinted genes in maize reveals allelic variation for imprinting and limited conservation with other species

    Amanda J. Waters, Paul Bilinski, Steven R. Eichten, Matthew W. Vaughn, Jeffrey Ross-Ibarra, Mary Gehring, and Nathan M. Springer

    PNAS November 26, 2013 110 (48) 19639-19644; https://doi.org/10.1073/pnas.1309182110

• Population Biology

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    Searching for efficient Markov chain Monte Carlo proposal kernels

    Ziheng Yang and Carlos E. Rodríguez

    PNAS November 26, 2013 110 (48) 19307-19312; https://doi.org/10.1073/pnas.1311790110
  • Open Access

    Pathogen selection drives nonoverlapping associations between HLA loci

    Bridget S. Penman, Ben Ashby, Caroline O. Buckee, and Sunetra Gupta

    PNAS November 26, 2013 110 (48) 19645-19650; https://doi.org/10.1073/pnas.1304218110

• Psychological and Cognitive Sciences

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    Similarity increases altruistic punishment in humans

    Thomas Mussweiler and Axel Ockenfels

    PNAS November 26, 2013 110 (48) 19318-19323; https://doi.org/10.1073/pnas.1215443110