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About the Cover

November 26, 2013; vol. 110 no. 48

This Week in PNAS

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    In This Issue
    PNAS November 26, 2013 110 (48) 19175-19176; https://doi.org/10.1073/iti4813110

Letters (Online Only)

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    Oxygen isotope anomaly not present in water vapor from Alert, Canada
    Martin F. Miller
    PNAS November 26, 2013 110 (48) E4567; https://doi.org/10.1073/pnas.1318925110
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    Reply to Miller: Concerning the oxygen isotope anomaly observed in water vapor from Alert, Canada, and its stratospheric source
    Ying Lin, Robert N. Clayton, Lin Huang, Noboru Nakamura, and James R. Lyons
    PNAS November 26, 2013 110 (48) E4568; https://doi.org/10.1073/pnas.1319439110

    See companion article:

    • Oxygen isotopes in high-latitude water vapor
      - Sep 05, 2013
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    Alternative explanation for indole-induced antibiotic tolerance in Salmonella
    Jessica M. A. Blair, Axel Cloeckaert, Kunihiko Nishino, and Laura J. V. Piddock
    PNAS November 26, 2013 110 (48) E4569; https://doi.org/10.1073/pnas.1318318110
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    Reply to Blair et al.: Dose-dependent effects and oxidative stress responses in antibiotic tolerance in Salmonella typhimurium
    Nicole M. Vega, Kyle R. Allison, Amanda N. Samuels, Mark S. Klempner, and James J. Collins
    PNAS November 26, 2013 110 (48) E4570; https://doi.org/10.1073/pnas.1318744110

    See companion article:

    • Salmonella use E. coli signal to enhance tolerance
      - Aug 14, 2013

Science and Culture

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    Digital dome
    • Front Matter
    J. D. Talasek
    PNAS November 26, 2013 110 (48) 19177; https://doi.org/10.1073/pnas.1318202110

QnAs

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    QnAs with John Clarke
    Farooq Ahmed
    PNAS November 26, 2013 110 (48) 19178; https://doi.org/10.1073/pnas.1319654110

    See companion article:

    • MRI of the human brain at 130 microtesla
      - Nov 19, 2013

Retrospective

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    Harold Agnew, physicist, atomic bomb Everyman
    William H. Press
    PNAS November 26, 2013 110 (48) 19179-19180; https://doi.org/10.1073/pnas.1319623110

Commentaries

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    Thermodynamically inspired classifier for molecular phenotypes of health and disease
    Marc T. Facciotti
    PNAS November 26, 2013 110 (48) 19181-19182; https://doi.org/10.1073/pnas.1317876110

    See companion article:

    • Cancer signature by surprisal analysis
      - Oct 07, 2013
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    HIV provides ample PAMPs for innate immune sensing
    Benhur Lee
    PNAS November 26, 2013 110 (48) 19183-19184; https://doi.org/10.1073/pnas.1319118110

    See companion article:

    • IFI16 is a sensor for HIV-1 RT products
      - Oct 23, 2013
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    Functional reconstitution of a chloride channel bares its soul
    H. Criss Hartzell and Chelsey Chandler Ruppersburg
    PNAS November 26, 2013 110 (48) 19185-19186; https://doi.org/10.1073/pnas.1319415110

    See companion article:

    • Reconstitution of TMEM16A
      - Oct 28, 2013
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    Local diversity stays about the same, regional diversity increases, and global diversity declines
    Chris D. Thomas
    PNAS November 26, 2013 110 (48) 19187-19188; https://doi.org/10.1073/pnas.1319304110

    See companion article:

    • No change over time in local plant diversity
      - Oct 28, 2013
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    More players in the plant unfolded response
    Alessandro Vitale
    PNAS November 26, 2013 110 (48) 19189-19190; https://doi.org/10.1073/pnas.1320254110

    See companion article:

    • NACs and VPE as a regulatory circuit of cell death
      - Oct 21, 2013
    • Function of IRE1 in plant growth and development
      - Oct 21, 2013

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.
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    PNAS Plus Significance Statements
    PNAS November 26, 2013 110 (48) 19191-19193; https://doi.org/10.1073/pnas.ss11048

Quantitative Geometry Special Feature (Free Online)

  • Introduction

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      Quantitative geometry
      Assaf Naor
      PNAS November 26, 2013 110 (48) 19202-19205; https://doi.org/10.1073/pnas.1320388110
  • Research Articles

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      Homological and homotopical Dehn functions are different
      • From the Cover
      Aaron Abrams, Noel Brady, Pallavi Dani, and Robert Young
      PNAS November 26, 2013 110 (48) 19206-19212; https://doi.org/10.1073/pnas.1207377110
    • You have access
      Fractional Sylvester–Gallai theorems
      Boaz Barak, Zeev Dvir, Avi Wigderson, and Amir Yehudayoff
      PNAS November 26, 2013 110 (48) 19213-19219; https://doi.org/10.1073/pnas.1203737109
    • You have access
      On the rate of convergence to the asymptotic cone for nilpotent groups and subFinsler geometry
      Emmanuel Breuillard and Enrico Le Donne
      PNAS November 26, 2013 110 (48) 19220-19226; https://doi.org/10.1073/pnas.1203854109
    • You have access
      Violating the Shannon capacity of metric graphs with entanglement
      Jop Briët, Harry Buhrman, and Dion Gijswijt
      PNAS November 26, 2013 110 (48) 19227-19232; https://doi.org/10.1073/pnas.1203857110
    • You have access
      Monotonicity and its analytic and geometric implications
      Tobias Holck Colding and William P. Minicozzi II
      PNAS November 26, 2013 110 (48) 19233-19236; https://doi.org/10.1073/pnas.1203856109
    • You have access
      Near-optimal deterministic algorithms for volume computation via M-ellipsoids
      Daniel Dadush and Santosh S. Vempala
      PNAS November 26, 2013 110 (48) 19237-19245; https://doi.org/10.1073/pnas.1203863110
    • You have access
      Quantitative algebraic topology and Lipschitz homotopy
      Steve Ferry and Shmuel Weinberger
      PNAS November 26, 2013 110 (48) 19246-19250; https://doi.org/10.1073/pnas.1208041110
    • You have access
      A quantitative version of the commutator theorem for zero trace matrices
      William B. Johnson, Narutaka Ozawa, and Gideon Schechtman
      PNAS November 26, 2013 110 (48) 19251-19255; https://doi.org/10.1073/pnas.1202411109
    • You have access
      Ultrametric skeletons
      Manor Mendel and Assaf Naor
      PNAS November 26, 2013 110 (48) 19256-19262; https://doi.org/10.1073/pnas.1202500109

Physical Sciences

  • Applied Physical Sciences

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      Quantifying the dynamic interactions between a clathrin-coated pit and cargo molecules
      Aubrey V. Weigel, Michael M. Tamkun, and Diego Krapf
      PNAS November 26, 2013 110 (48) E4591-E4600; https://doi.org/10.1073/pnas.1315202110
    • You have access
      MRI of the human brain at 130 microtesla
      • Inaugural Article
      Ben Inglis, Kai Buckenmaier, Paul SanGiorgio, Anders F. Pedersen, Matthew A. Nichols, and John Clarke
      PNAS November 26, 2013 110 (48) 19194-19201; https://doi.org/10.1073/pnas.1319334110

      See companion article:

      • QnAs with John Clarke
        - Nov 11, 2013
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      Three-dimensional textures and defects of soft material layering revealed by thermal sublimation
      Dong Ki Yoon, Yun Ho Kim, Dae Seok Kim, Seong Dae Oh, Ivan I. Smalyukh, Noel A. Clark, and Hee-Tae Jung
      PNAS November 26, 2013 110 (48) 19263-19267; https://doi.org/10.1073/pnas.1317922110
    • Open Access
      Motionless phase stepping in X-ray phase contrast imaging with a compact source
      Houxun Miao, Lei Chen, Eric E. Bennett, Nick M. Adamo, Andrew A. Gomella, Alexa M. DeLuca, Ajay Patel, Nicole Y. Morgan, and Han Wen
      PNAS November 26, 2013 110 (48) 19268-19272; https://doi.org/10.1073/pnas.1311053110
  • Astronomy

    • Open Access
      Prevalence of Earth-size planets orbiting Sun-like stars
      • Cozzarelli Prize Winner
      Erik A. Petigura, Andrew W. Howard, and Geoffrey W. Marcy
      PNAS November 26, 2013 110 (48) 19273-19278; https://doi.org/10.1073/pnas.1319909110
  • Chemistry

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      Islet amyloid polypeptide toxicity and membrane interactions
      Ping Cao, Andisheh Abedini, Hui Wang, Ling-Hsien Tu, Xiaoxue Zhang, Ann Marie Schmidt, and Daniel P. Raleigh
      PNAS November 26, 2013 110 (48) 19279-19284; https://doi.org/10.1073/pnas.1305517110
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      Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet
      Lauren E. Buchanan, Emily B. Dunkelberger, Huong Q. Tran, Pin-Nan Cheng, Chi-Cheng Chiu, Ping Cao, Daniel P. Raleigh, Juan J. de Pablo, James S. Nowick, and Martin T. Zanni
      PNAS November 26, 2013 110 (48) 19285-19290; https://doi.org/10.1073/pnas.1314481110
    • You have access
      Impact of reconstituted cytosol on protein stability
      Mohona Sarkar, Austin E. Smith, and Gary J. Pielak
      PNAS November 26, 2013 110 (48) 19342-19347; https://doi.org/10.1073/pnas.1312678110
  • Computer Sciences

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      Near-optimal deterministic algorithms for volume computation via M-ellipsoids
      Daniel Dadush and Santosh S. Vempala
      PNAS November 26, 2013 110 (48) 19237-19245; https://doi.org/10.1073/pnas.1203863110
  • Earth, Atmospheric, and Planetary Sciences

    • Open Access
      Microphysical effects determine macrophysical response for aerosol impacts on deep convective clouds
      Jiwen Fan, L. Ruby Leung, Daniel Rosenfeld, Qian Chen, Zhanqing Li, Jinqiang Zhang, and Hongru Yan
      PNAS November 26, 2013 110 (48) E4581-E4590; https://doi.org/10.1073/pnas.1316830110
  • Engineering

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      Comminution of solids caused by kinetic energy of high shear strain rate, with implications for impact, shock, and shale fracturing
      Zdeněk P. Bažant and Ferhun C. Caner
      PNAS November 26, 2013 110 (48) 19291-19294; https://doi.org/10.1073/pnas.1318739110
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      Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins
      Jihye Seong, Arash Tajik, Jie Sun, Jun-Lin Guan, Martin J. Humphries, Susan E. Craig, Asha Shekaran, Andrés J. García, Shaoying Lu, Michael Z. Lin, Ning Wang, and Yingxiao Wang
      PNAS November 26, 2013 110 (48) 19372-19377; https://doi.org/10.1073/pnas.1307405110
  • Environmental Sciences

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      Exploring network scaling through variations on optimal channel networks
      Lily A. Briggs and Mukkai Krishnamoorthy
      PNAS November 26, 2013 110 (48) 19295-19300; https://doi.org/10.1073/pnas.1313866110
    • Open Access
      Identifying external influences on global precipitation
      Kate Marvel and Céline Bonfils
      PNAS November 26, 2013 110 (48) 19301-19306; https://doi.org/10.1073/pnas.1314382110
  • Mathematics

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      Homological and homotopical Dehn functions are different
      • From the Cover
      Aaron Abrams, Noel Brady, Pallavi Dani, and Robert Young
      PNAS November 26, 2013 110 (48) 19206-19212; https://doi.org/10.1073/pnas.1207377110
    • You have access
      Fractional Sylvester–Gallai theorems
      Boaz Barak, Zeev Dvir, Avi Wigderson, and Amir Yehudayoff
      PNAS November 26, 2013 110 (48) 19213-19219; https://doi.org/10.1073/pnas.1203737109
    • You have access
      On the rate of convergence to the asymptotic cone for nilpotent groups and subFinsler geometry
      Emmanuel Breuillard and Enrico Le Donne
      PNAS November 26, 2013 110 (48) 19220-19226; https://doi.org/10.1073/pnas.1203854109
    • You have access
      Violating the Shannon capacity of metric graphs with entanglement
      Jop Briët, Harry Buhrman, and Dion Gijswijt
      PNAS November 26, 2013 110 (48) 19227-19232; https://doi.org/10.1073/pnas.1203857110
    • You have access
      Monotonicity and its analytic and geometric implications
      Tobias Holck Colding and William P. Minicozzi II
      PNAS November 26, 2013 110 (48) 19233-19236; https://doi.org/10.1073/pnas.1203856109
    • You have access
      Quantitative algebraic topology and Lipschitz homotopy
      Steve Ferry and Shmuel Weinberger
      PNAS November 26, 2013 110 (48) 19246-19250; https://doi.org/10.1073/pnas.1208041110
    • You have access
      A quantitative version of the commutator theorem for zero trace matrices
      William B. Johnson, Narutaka Ozawa, and Gideon Schechtman
      PNAS November 26, 2013 110 (48) 19251-19255; https://doi.org/10.1073/pnas.1202411109
    • You have access
      Ultrametric skeletons
      Manor Mendel and Assaf Naor
      PNAS November 26, 2013 110 (48) 19256-19262; https://doi.org/10.1073/pnas.1202500109
  • Statistics

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      Searching for efficient Markov chain Monte Carlo proposal kernels
      Ziheng Yang and Carlos E. Rodríguez
      PNAS November 26, 2013 110 (48) 19307-19312; https://doi.org/10.1073/pnas.1311790110
    • Open Access
      Revised standards for statistical evidence
      Valen E. Johnson
      PNAS November 26, 2013 110 (48) 19313-19317; https://doi.org/10.1073/pnas.1313476110

      See companion article:

      • More reasons to revise standards for evidence
        - Apr 23, 2014

Social Sciences

  • Economic Sciences

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      Similarity increases altruistic punishment in humans
      Thomas Mussweiler and Axel Ockenfels
      PNAS November 26, 2013 110 (48) 19318-19323; https://doi.org/10.1073/pnas.1215443110

Biological Sciences

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      Host-induced gene silencing of cytochrome P450 lanosterol C14α-demethylase–encoding genes confers strong resistance to Fusarium species
      Aline Koch, Neelendra Kumar, Lennart Weber, Harald Keller, Jafargholi Imani, and Karl-Heinz Kogel
      PNAS November 26, 2013 110 (48) 19324-19329; https://doi.org/10.1073/pnas.1306373110
  • Applied Biological Sciences

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      Antibody biomarker discovery through in vitro directed evolution of consensus recognition epitopes
      John T. Ballew, Joseph A. Murray, Pekka Collin, Markku Mäki, Martin F. Kagnoff, Katri Kaukinen, and Patrick S. Daugherty
      PNAS November 26, 2013 110 (48) 19330-19335; https://doi.org/10.1073/pnas.1314792110
    • You have access
      Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway
      Huan Wang, Mark W. Tibbitt, Stephen J. Langer, Leslie A. Leinwand, and Kristi S. Anseth
      PNAS November 26, 2013 110 (48) 19336-19341; https://doi.org/10.1073/pnas.1306369110
  • Biochemistry

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      Structural and genetic analyses reveal the protein SepF as a new membrane anchor for the Z ring
      Ramona Duman, Shu Ishikawa, Ilkay Celik, Henrik Strahl, Naotake Ogasawara, Paulina Troc, Jan Löwe, and Leendert W. Hamoen
      PNAS November 26, 2013 110 (48) E4601-E4610; https://doi.org/10.1073/pnas.1313978110
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      Crystal structure of the human eIF4AIII–CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain
      Gretel Buchwald, Steffen Schüssler, Claire Basquin, Hervé Le Hir, and Elena Conti
      PNAS November 26, 2013 110 (48) E4611-E4618; https://doi.org/10.1073/pnas.1314684110
    • You have access
      Impact of reconstituted cytosol on protein stability
      Mohona Sarkar, Austin E. Smith, and Gary J. Pielak
      PNAS November 26, 2013 110 (48) 19342-19347; https://doi.org/10.1073/pnas.1312678110
    • Open Access
      Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy
      Zhenxi Zhang, Anna Maria Pinto, Lili Wan, Wei Wang, Michael G. Berg, Isabela Oliva, Larry N. Singh, Christopher Dengler, Zhi Wei, and Gideon Dreyfuss
      PNAS November 26, 2013 110 (48) 19348-19353; https://doi.org/10.1073/pnas.1319280110
    • You have access
      Purified TMEM16A is sufficient to form Ca2+-activated Cl− channels
      • From the Cover
      Hiroyuki Terashima, Alessandra Picollo, and Alessio Accardi
      PNAS November 26, 2013 110 (48) 19354-19359; https://doi.org/10.1073/pnas.1312014110

      See companion article:

      • Functional reconstitution of a chloride channel
        - Nov 14, 2013
    • You have access
      Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140
      Won-Kyu Lee, Sang Hyeon Son, Bong-Suk Jin, Jung-Hyun Na, Soo-Youl Kim, Kook-Han Kim, Eunice EunKyeong Kim, Yeon Gyu Yu, and Hyung Ho Lee
      PNAS November 26, 2013 110 (48) 19360-19365; https://doi.org/10.1073/pnas.1304670110
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      Metabolically programmed quality control system for dolichol-linked oligosaccharides
      Yoichiro Harada, Kazuki Nakajima, Yuki Masahara-Negishi, Hudson H. Freeze, Takashi Angata, Naoyuki Taniguchi, and Tadashi Suzuki
      PNAS November 26, 2013 110 (48) 19366-19371; https://doi.org/10.1073/pnas.1312187110
  • Biophysics and Computational Biology

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      Quantifying the dynamic interactions between a clathrin-coated pit and cargo molecules
      Aubrey V. Weigel, Michael M. Tamkun, and Diego Krapf
      PNAS November 26, 2013 110 (48) E4591-E4600; https://doi.org/10.1073/pnas.1315202110
    • You have access
      Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins
      Jihye Seong, Arash Tajik, Jie Sun, Jun-Lin Guan, Martin J. Humphries, Susan E. Craig, Asha Shekaran, Andrés J. García, Shaoying Lu, Michael Z. Lin, Ning Wang, and Yingxiao Wang
      PNAS November 26, 2013 110 (48) 19372-19377; https://doi.org/10.1073/pnas.1307405110
    • You have access
      Detection of single photons by toad and mouse rods
      Jürgen Reingruber, Johan Pahlberg, Michael L. Woodruff, Alapakkam P. Sampath, Gordon L. Fain, and David Holcman
      PNAS November 26, 2013 110 (48) 19378-19383; https://doi.org/10.1073/pnas.1314030110
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      Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate
      Binyong Liang, Volker Kiessling, and Lukas K. Tamm
      PNAS November 26, 2013 110 (48) 19384-19389; https://doi.org/10.1073/pnas.1314699110
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      Structural insights into the histone H1-nucleosome complex
      Bing-Rui Zhou, Hanqiao Feng, Hidenori Kato, Liang Dai, Yuedong Yang, Yaoqi Zhou, and Yawen Bai
      PNAS November 26, 2013 110 (48) 19390-19395; https://doi.org/10.1073/pnas.1314905110
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      Single-molecule resolution of protein structure and interfacial dynamics on biomaterial surfaces
      Sean Yu McLoughlin, Mark Kastantin, Daniel K. Schwartz, and Joel L. Kaar
      PNAS November 26, 2013 110 (48) 19396-19401; https://doi.org/10.1073/pnas.1311761110
  • Cell Biology

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      Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
      Carlos Carmona-Fontaine, Vanni Bucci, Leila Akkari, Maxime Deforet, Johanna A. Joyce, and Joao B. Xavier
      PNAS November 26, 2013 110 (48) 19402-19407; https://doi.org/10.1073/pnas.1311939110
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      Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species
      Jaakko L. O. Pohjoismäki, Siôn L. Williams, Thomas Boettger, Steffi Goffart, Johnny Kim, Anu Suomalainen, Carlos T. Moraes, and Thomas Braun
      PNAS November 26, 2013 110 (48) 19408-19413; https://doi.org/10.1073/pnas.1303046110
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      Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer
      Soo J. Shin, Jeffrey A. Smith, Günther A. Rezniczek, Sheng Pan, Ru Chen, Teresa A. Brentnall, Gerhard Wiche, and Kimberly A. Kelly
      PNAS November 26, 2013 110 (48) 19414-19419; https://doi.org/10.1073/pnas.1309720110
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      Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy
      Mica Ohara-Imaizumi, Hail Kim, Masashi Yoshida, Tomonori Fujiwara, Kyota Aoyagi, Yukiko Toyofuku, Yoko Nakamichi, Chiyono Nishiwaki, Tadashi Okamura, Toyoyoshi Uchida, Yoshio Fujitani, Kimio Akagawa, Masafumi Kakei, Hirotaka Watada, Michael S. German, and Shinya Nagamatsu
      PNAS November 26, 2013 110 (48) 19420-19425; https://doi.org/10.1073/pnas.1310953110
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      Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition
      Donald S. Kirkpatrick, Daisy J. Bustos, Taner Dogan, Jocelyn Chan, Lilian Phu, Amy Young, Lori S. Friedman, Marcia Belvin, Qinghua Song, Corey E. Bakalarski, and Klaus P. Hoeflich
      PNAS November 26, 2013 110 (48) 19426-19431; https://doi.org/10.1073/pnas.1309473110
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      The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway
      Dongyan Tan, Yiying Cai, Juan Wang, Jinzhong Zhang, Shekar Menon, Hui-Ting Chou, Susan Ferro-Novick, Karin M. Reinisch, and Thomas Walz
      PNAS November 26, 2013 110 (48) 19432-19437; https://doi.org/10.1073/pnas.1316356110
  • Developmental Biology

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      Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb
      Ben Xu, Steven M. Hrycaj, Daniel C. McIntyre, Nicholas C. Baker, Jun K. Takeuchi, Lucie Jeannotte, Zachary B. Gaber, Bennett G. Novitch, and Deneen M. Wellik
      PNAS November 26, 2013 110 (48) 19438-19443; https://doi.org/10.1073/pnas.1315075110
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      Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways
      Elizabeth A. Hines, Mary-Kayt N. Jones, Jamie M. Verheyden, Julie F. Harvey, and Xin Sun
      PNAS November 26, 2013 110 (48) 19444-19449; https://doi.org/10.1073/pnas.1313223110
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      Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation
      Lick Pui Lai, Brendan N. Lilley, Joshua R. Sanes, and Andrew P. McMahon
      PNAS November 26, 2013 110 (48) 19450-19455; https://doi.org/10.1073/pnas.1309001110
  • Ecology

    • You have access
      Global meta-analysis reveals no net change in local-scale plant biodiversity over time
      • From the Cover
      Mark Vellend, Lander Baeten, Isla H. Myers-Smith, Sarah C. Elmendorf, Robin Beauséjour, Carissa D. Brown, Pieter De Frenne, Kris Verheyen, and Sonja Wipf
      PNAS November 26, 2013 110 (48) 19456-19459; https://doi.org/10.1073/pnas.1312779110

      See companion article:

      • Biodiversity crisis?
        - Nov 18, 2013
  • Evolution

    • You have access
      Gene amplification and microsatellite polymorphism underlie a recent insect host shift
      Chris Bass, Christoph T. Zimmer, Jacob M. Riveron, Craig S. Wilding, Charles S. Wondji, Martin Kaussmann, Linda M. Field, Martin S. Williamson, and Ralf Nauen
      PNAS November 26, 2013 110 (48) 19460-19465; https://doi.org/10.1073/pnas.1314122110
  • Genetics

    • Open Access
      Intrinsic karyotype stability and gene copy number variations may have laid the foundation for tetraploid wheat formation
      Huakun Zhang, Yao Bian, Xiaowan Gou, Yuzhu Dong, Sachin Rustgi, Bangjiao Zhang, Chunming Xu, Ning Li, Bao Qi, Fangpu Han, Diter von Wettstein, and Bao Liu
      PNAS November 26, 2013 110 (48) 19466-19471; https://doi.org/10.1073/pnas.1319598110
    • You have access
      Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH
      Maria Suntsova, Elena V. Gogvadze, Sergey Salozhin, Nurshat Gaifullin, Fedor Eroshkin, Sergey E. Dmitriev, Natalia Martynova, Kirill Kulikov, Galina Malakhova, Gulnur Tukhbatova, Alexey P. Bolshakov, Dmitry Ghilarov, Andrew Garazha, Alexander Aliper, Charles R. Cantor, Yuri Solokhin, Sergey Roumiantsev, Pavel Balaban, Alex Zhavoronkov, and Anton Buzdin
      PNAS November 26, 2013 110 (48) 19472-19477; https://doi.org/10.1073/pnas.1318172110
    • Open Access
      Fine-scale variation in meiotic recombination in Mimulus inferred from population shotgun sequencing
      Uffe Hellsten, Kevin M. Wright, Jerry Jenkins, Shengqiang Shu, Yaowu Yuan, Susan R. Wessler, Jeremy Schmutz, John H. Willis, and Daniel S. Rokhsar
      PNAS November 26, 2013 110 (48) 19478-19482; https://doi.org/10.1073/pnas.1319032110
    • You have access
      Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons
      Christiane Kuschal, John. J. DiGiovanna, Sikandar G. Khan, Richard A. Gatti, and Kenneth H. Kraemer
      PNAS November 26, 2013 110 (48) 19483-19488; https://doi.org/10.1073/pnas.1312088110
    • Open Access
      Synthetic lethality between CCNE1 amplification and loss of BRCA1
      Dariush Etemadmoghadam, Barbara A. Weir, George Au-Yeung, Kathryn Alsop, Gillian Mitchell, Joshy George, Australian Ovarian Cancer Study Group, Sally Davis, Alan D. D’Andrea, Kaylene Simpson, William C. Hahn, and David D. L. Bowtell
      PNAS November 26, 2013 110 (48) 19489-19494; https://doi.org/10.1073/pnas.1314302110
    • You have access
      Genetic variants related to gap junctions and hormone secretion influence conception rates in cows
      Mayumi Sugimoto, Shinji Sasaki, Yusaku Gotoh, Yuuki Nakamura, Yoshito Aoyagi, Takayoshi Kawahara, and Yoshikazu Sugimoto
      PNAS November 26, 2013 110 (48) 19495-19500; https://doi.org/10.1073/pnas.1309307110
  • Immunology

    • You have access
      IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
      • From the Cover
      Martin R. Jakobsen, Rasmus O. Bak, Annika Andersen, Randi K. Berg, Søren B. Jensen, Tengchuan Jin, Anders Laustsen, Kathrine Hansen, Lars Østergaard, Katherine A. Fitzgerald, T. Sam Xiao, Jacob G. Mikkelsen, Trine H. Mogensen, and Søren R. Paludan
      PNAS November 26, 2013 110 (48) E4571-E4580; https://doi.org/10.1073/pnas.1311669110

      See companion article:

      • HIV provides ample PAMPs
        - Nov 13, 2013
    • You have access
      Growth hormone prevents the development of autoimmune diabetes
      Ricardo Villares, Dimitri Kakabadse, Yasmina Juarranz, Rosa P. Gomariz, Carlos Martínez-A, and Mario Mellado
      PNAS November 26, 2013 110 (48) E4619-E4627; https://doi.org/10.1073/pnas.1314985110
    • You have access
      Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2
      Elizabeth A. W. Chan, Grace Teng, Elizabeth Corbett, Kingshuk Roy Choudhury, Craig H. Bassing, David G. Schatz, and Michael S. Krangel
      PNAS November 26, 2013 110 (48) E4628-E4637; https://doi.org/10.1073/pnas.1310846110
    • You have access
      Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo
      Fubin Li and Jeffrey V. Ravetch
      PNAS November 26, 2013 110 (48) 19501-19506; https://doi.org/10.1073/pnas.1319502110
  • Medical Sciences

    • Open Access
      Bioavailable copper modulates oxidative phosphorylation and growth of tumors
      Seiko Ishida, Pénélope Andreux, Carole Poitry-Yamate, Johan Auwerx, and Douglas Hanahan
      PNAS November 26, 2013 110 (48) 19507-19512; https://doi.org/10.1073/pnas.1318431110
    • Open Access
      Mouse model of intrahepatic cholangiocarcinoma validates FIG–ROS as a potent fusion oncogene and therapeutic target
      Anna Saborowski, Michael Saborowski, Monika A. Davare, Brian J. Druker, David S. Klimstra, and Scott W. Lowe
      PNAS November 26, 2013 110 (48) 19513-19518; https://doi.org/10.1073/pnas.1311707110

      See companion article:

      • Foretinib is a potent ROS1 inhibitor
        - Nov 11, 2013
    • You have access
      Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins
      Monika A. Davare, Anna Saborowski, Christopher A. Eide, Cristina Tognon, Rebecca L. Smith, Johannes Elferich, Anupriya Agarwal, Jeffrey W. Tyner, Ujwal P. Shinde, Scott W. Lowe, and Brian J. Druker
      PNAS November 26, 2013 110 (48) 19519-19524; https://doi.org/10.1073/pnas.1319583110

      See companion article:

      • FIG–ROS is a promising therapeutic target in ICC
        - Oct 23, 2013
    • You have access
      CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome
      Vincent J. Guen, Carly Gamble, Marc Flajolet, Sheila Unger, Aurélie Thollet, Yoan Ferandin, Andrea Superti-Furga, Pascale A. Cohen, Laurent Meijer, and Pierre Colas
      PNAS November 26, 2013 110 (48) 19525-19530; https://doi.org/10.1073/pnas.1306814110
    • You have access
      TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection
      Lígia Antunes Gonçalves, Lurdes Rodrigues-Duarte, Joana Rodo, Luciana Vieira de Moraes, Isabel Marques, and Carlos Penha-Gonçalves
      PNAS November 26, 2013 110 (48) 19531-19536; https://doi.org/10.1073/pnas.1306873110
    • You have access
      Keratin 16 regulates innate immunity in response to epidermal barrier breach
      Juliane C. Lessard, Sylvia Piña-Paz, Jeremy D. Rotty, Robyn P. Hickerson, Roger L. Kaspar, Allan Balmain, and Pierre A. Coulombe
      PNAS November 26, 2013 110 (48) 19537-19542; https://doi.org/10.1073/pnas.1309576110
  • Microbiology

    • Open Access
      Structure and assembly of an inner membrane platform for initiation of type IV pilus biogenesis
      Vijaykumar Karuppiah, Richard F. Collins, Angela Thistlethwaite, Ya Gao, and Jeremy P. Derrick
      PNAS November 26, 2013 110 (48) E4638-E4647; https://doi.org/10.1073/pnas.1312313110
    • You have access
      Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network
      Lars Plate and Michael A. Marletta
      PNAS November 26, 2013 110 (48) E4648-E4657; https://doi.org/10.1073/pnas.1318128110
    • You have access
      Global methylation state at base-pair resolution of the Caulobacter genome throughout the cell cycle
      Jennifer B. Kozdon, Michael D. Melfi, Khai Luong, Tyson A. Clark, Matthew Boitano, Susana Wang, Bo Zhou, Diego Gonzalez, Justine Collier, Stephen W. Turner, Jonas Korlach, Lucy Shapiro, and Harley H. McAdams
      PNAS November 26, 2013 110 (48) E4658-E4667; https://doi.org/10.1073/pnas.1319315110
    • You have access
      Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein
      Jessica S. Schneider, Shilpa P. Reddy, Hock Y. E, Henry W. Evans, and Michael S. Glickman
      PNAS November 26, 2013 110 (48) 19543-19548; https://doi.org/10.1073/pnas.1305934110
    • You have access
      Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division
      Ruth Kiro, Shahar Molshanski-Mor, Ido Yosef, Sara L. Milam, Harold P. Erickson, and Udi Qimron
      PNAS November 26, 2013 110 (48) 19549-19554; https://doi.org/10.1073/pnas.1314096110
  • Neuroscience

    • Open Access
      Dynamic faces speed up the onset of auditory cortical spiking responses during vocal detection
      Chandramouli Chandrasekaran, Luis Lemus, and Asif A. Ghazanfar
      PNAS November 26, 2013 110 (48) E4668-E4677; https://doi.org/10.1073/pnas.1312518110
    • You have access
      Rapid stimulus-evoked astrocyte Ca2+ elevations and hemodynamic responses in mouse somatosensory cortex in vivo
      Barbara Lykke Lind, Alexey R. Brazhe, Sanne Barsballe Jessen, Florence C. C. Tan, and Martin J. Lauritzen
      PNAS November 26, 2013 110 (48) E4678-E4687; https://doi.org/10.1073/pnas.1310065110
    • You have access
      Transmission of multiple system atrophy prions to transgenic mice
      Joel C. Watts, Kurt Giles, Abby Oehler, Lefkos Middleton, David T. Dexter, Steve M. Gentleman, Stephen J. DeArmond, and Stanley B. Prusiner
      PNAS November 26, 2013 110 (48) 19555-19560; https://doi.org/10.1073/pnas.1318268110
    • You have access
      Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration
      Arati A. Inamdar, Muhammad M. Hossain, Alison I. Bernstein, Gary W. Miller, Jason R. Richardson, and Joan Wennstrom Bennett
      PNAS November 26, 2013 110 (48) 19561-19566; https://doi.org/10.1073/pnas.1318830110
    • You have access
      BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer’s disease
      Rebecca M. Burke, Timothy A. Norman, Tarik F. Haydar, Barbara E. Slack, Susan E. Leeman, Jan Krzysztof Blusztajn, and Tiffany J. Mellott
      PNAS November 26, 2013 110 (48) 19567-19572; https://doi.org/10.1073/pnas.1319297110
    • You have access
      Differential effects of global versus local testosterone on singing behavior and its underlying neural substrate
      Beau A. Alward, Jacques Balthazart, and Gregory F. Ball
      PNAS November 26, 2013 110 (48) 19573-19578; https://doi.org/10.1073/pnas.1311371110
    • You have access
      High-affinity olfactory receptor for the death-associated odor cadaverine
      Ashiq Hussain, Luis R. Saraiva, David M. Ferrero, Gaurav Ahuja, Venkatesh S. Krishna, Stephen D. Liberles, and Sigrun I. Korsching
      PNAS November 26, 2013 110 (48) 19579-19584; https://doi.org/10.1073/pnas.1318596110
    • You have access
      Frequency-specific mechanism links human brain networks for spatial attention
      Amy L. Daitch, Mohit Sharma, Jarod L. Roland, Serguei V. Astafiev, David T. Bundy, Charles M. Gaona, Abraham Z. Snyder, Gordon L. Shulman, Eric C. Leuthardt, and Maurizio Corbetta
      PNAS November 26, 2013 110 (48) 19585-19590; https://doi.org/10.1073/pnas.1307947110
    • You have access
      Persistence of hippocampal multivoxel patterns into postencoding rest is related to memory
      Arielle Tambini and Lila Davachi
      PNAS November 26, 2013 110 (48) 19591-19596; https://doi.org/10.1073/pnas.1308499110
    • You have access
      Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans
      Oliver G. Bosch, Julia S. Rihm, Milan Scheidegger, Hans-Peter Landolt, Philipp Stämpfli, Janis Brakowski, Fabrizio Esposito, Björn Rasch, and Erich Seifritz
      PNAS November 26, 2013 110 (48) 19597-19602; https://doi.org/10.1073/pnas.1317010110
    • You have access
      ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity
      Robert M. Mitchell, Megan J. Janssen, Irina Karavanova, Detlef Vullhorst, Katrina Furth, Anthony Makusky, Sanford P. Markey, and Andres Buonanno
      PNAS November 26, 2013 110 (48) 19603-19608; https://doi.org/10.1073/pnas.1312791110
    • You have access
      Serotonin selectively enhances perception and sensory neural responses to stimuli generated by same-sex conspecifics
      Tara Deemyad, Michael G. Metzen, Yingzhou Pan, and Maurice J. Chacron
      PNAS November 26, 2013 110 (48) 19609-19614; https://doi.org/10.1073/pnas.1314008110
  • Pharmacology

    • You have access
      Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses
      Bin Gong, Thomas Shelite, Fang C. Mei, Tuha Ha, Yaohua Hu, Guang Xu, Qing Chang, Maki Wakamiya, Thomas G. Ksiazek, Paul J. Boor, Donald H. Bouyer, Vsevolod L. Popov, Ju Chen, David H. Walker, and Xiaodong Cheng
      PNAS November 26, 2013 110 (48) 19615-19620; https://doi.org/10.1073/pnas.1314400110
  • Physiology

    • You have access
      Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response
      Ying Fu, Ruth E. Westenbroek, Todd Scheuer, and William A. Catterall
      PNAS November 26, 2013 110 (48) 19621-19626; https://doi.org/10.1073/pnas.1319421110
  • Plant Biology

    • You have access
      Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by interacting with each other via the PPC/DUF296 domain
      Jianfei Zhao, David S. Favero, Hao Peng, and Michael M. Neff
      PNAS November 26, 2013 110 (48) E4688-E4697; https://doi.org/10.1073/pnas.1219277110
    • Open Access
      GmNAC30 and GmNAC81 integrate the endoplasmic reticulum stress- and osmotic stress-induced cell death responses through a vacuolar processing enzyme
      Giselle C. Mendes, Pedro A. B. Reis, Iara P. Calil, Humberto H. Carvalho, Francisco J. L. Aragão, and Elizabeth P. B. Fontes
      PNAS November 26, 2013 110 (48) 19627-19632; https://doi.org/10.1073/pnas.1311729110

      See companion article:

      • Players in the plant unfolded response
        - Nov 13, 2013
    • Open Access
      Protein kinase and ribonuclease domains of IRE1 confer stress tolerance, vegetative growth, and reproductive development in Arabidopsis
      Yan Deng, Renu Srivastava, and Stephen H. Howell
      PNAS November 26, 2013 110 (48) 19633-19638; https://doi.org/10.1073/pnas.1314749110

      See companion article:

      • Players in the plant unfolded response
        - Nov 13, 2013
    • You have access
      Comprehensive analysis of imprinted genes in maize reveals allelic variation for imprinting and limited conservation with other species
      Amanda J. Waters, Paul Bilinski, Steven R. Eichten, Matthew W. Vaughn, Jeffrey Ross-Ibarra, Mary Gehring, and Nathan M. Springer
      PNAS November 26, 2013 110 (48) 19639-19644; https://doi.org/10.1073/pnas.1309182110
  • Population Biology

    • You have access
      Searching for efficient Markov chain Monte Carlo proposal kernels
      Ziheng Yang and Carlos E. Rodríguez
      PNAS November 26, 2013 110 (48) 19307-19312; https://doi.org/10.1073/pnas.1311790110
    • Open Access
      Pathogen selection drives nonoverlapping associations between HLA loci
      Bridget S. Penman, Ben Ashby, Caroline O. Buckee, and Sunetra Gupta
      PNAS November 26, 2013 110 (48) 19645-19650; https://doi.org/10.1073/pnas.1304218110
  • Psychological and Cognitive Sciences

    • You have access
      Similarity increases altruistic punishment in humans
      Thomas Mussweiler and Axel Ockenfels
      PNAS November 26, 2013 110 (48) 19318-19323; https://doi.org/10.1073/pnas.1215443110

Corrections

  • You have access
    Correction for Petigura et al., Prevalence of Earth-size planets orbiting Sun-like stars
    PNAS November 26, 2013 110 (48) 19652; https://doi.org/10.1073/pnas.1321363110
  • You have access
    Correction for Briët et al., Violating the Shannon capacity of metric graphs with entanglement
    PNAS November 26, 2013 110 (48) 19651; https://doi.org/10.1073/pnas.1301191110
  • You have access
    Correction for Li et al., Mechanism of E-cadherin dimerization probed by NMR relaxation dispersion
    PNAS November 26, 2013 110 (48) 19651; https://doi.org/10.1073/pnas.1319465110
  • You have access
    Correction for Breau et al., A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling
    PNAS November 26, 2013 110 (48) 19651; https://doi.org/10.1073/pnas.1319266110
  • You have access
    Correction for Jakobsen et al., IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
    PNAS November 26, 2013 110 (48) 19651; https://doi.org/10.1073/pnas.1320190110
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Proceedings of the National Academy of Sciences: 110 (48)
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