Table of Contents

Biological Sciences

• Anthropology

  • Open Access

    The characteristics and chronology of the earliest Acheulean at Konso, Ethiopia

    • Inaugural Article

    Yonas Beyene, Shigehiro Katoh, Giday WoldeGabriel, William K. Hart, Kozo Uto, Masafumi Sudo, Megumi Kondo, Masayuki Hyodo, Paul R. Renne, Gen Suwa, and Berhane Asfaw

    PNAS January 29, 2013 110 (5) 1584-1591; https://doi.org/10.1073/pnas.1221285110

• Applied Biological Sciences

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    Impact of seawater acidification on pH at the tissue–skeleton interface and calcification in reef corals

    • From the Cover

    Alexander A. Venn, Eric Tambutté, Michael Holcomb, Julien Laurent, Denis Allemand, and Sylvie Tambutté

    PNAS January 29, 2013 110 (5) 1634-1639; https://doi.org/10.1073/pnas.1216153110

    See companion article:

    • Coral Calcification feels the acid

      - Jan 17, 2013
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    Generation of functional eggs and sperm from cryopreserved whole testes

    Seungki Lee, Yoshiko Iwasaki, Shinya Shikina, and Goro Yoshizaki

    PNAS January 29, 2013 110 (5) 1640-1645; https://doi.org/10.1073/pnas.1218468110

• Biochemistry

  • Open Access

    NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase

    Zhinan Jin, Vincent Leveque, Han Ma, Kenneth A. Johnson, and Klaus Klumpp

    PNAS January 29, 2013 110 (5) E348-E357; https://doi.org/10.1073/pnas.1214924110
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    Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases

    Ryan D. Baldridge and Todd R. Graham

    PNAS January 29, 2013 110 (5) E358-E367; https://doi.org/10.1073/pnas.1216948110
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    Transmembrane helix orientation influences membrane binding of the intracellular juxtamembrane domain in Neu receptor peptides

    Chihiro Matsushita, Hiroko Tamagaki, Yudai Miyazawa, Saburo Aimoto, Steven O. Smith, and Takeshi Sato

    PNAS January 29, 2013 110 (5) 1646-1651; https://doi.org/10.1073/pnas.1215207110
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    Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

    Jesse Donovan, Matthew Dufner, and Alexei Korennykh

    PNAS January 29, 2013 110 (5) 1652-1657; https://doi.org/10.1073/pnas.1218528110
  • Open Access

    Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair

    Mihaela Robu, Rashmi G. Shah, Nancy Petitclerc, Julie Brind’Amour, Febitha Kandan-Kulangara, and Girish M. Shah

    PNAS January 29, 2013 110 (5) 1658-1663; https://doi.org/10.1073/pnas.1209507110

• Biophysics and Computational Biology

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    Propulsion of microorganisms by a helical flagellum

    Bruce Rodenborn, Chih-Hung Chen, Harry L. Swinney, Bin Liu, and H. P. Zhang

    PNAS January 29, 2013 110 (5) E338-E347; https://doi.org/10.1073/pnas.1219831110
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    High-pressure NMR reveals close similarity between cold and alcohol protein denaturation in ubiquitin

    Navratna Vajpai, Lydia Nisius, Maciej Wiktor, and Stephan Grzesiek

    PNAS January 29, 2013 110 (5) E368-E376; https://doi.org/10.1073/pnas.1212222110
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    Snapshots of a protein folding intermediate

    Seiji Yamada, Nicole D. Bouley Ford, Gretchen E. Keller, William C. Ford, Harry B. Gray, and Jay R. Winkler

    PNAS January 29, 2013 110 (5) 1606-1610; https://doi.org/10.1073/pnas.1221832110
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    Explaining why Gleevec is a specific and potent inhibitor of Abl kinase

    Yen-Lin Lin, Yilin Meng, Wei Jiang, and Benoît Roux

    PNAS January 29, 2013 110 (5) 1664-1669; https://doi.org/10.1073/pnas.1214330110
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    Properties of hydrophobic free energy found by gas–liquid transfer

    Robert L. Baldwin

    PNAS January 29, 2013 110 (5) 1670-1673; https://doi.org/10.1073/pnas.1220825110
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    Caulobacter chromosome in vivo configuration matches model predictions for a supercoiled polymer in a cell-like confinement

    Sun-Hae Hong, Esteban Toro, Kim I. Mortensen, Mario A. Díaz de la Rosa, Sebastian Doniach, Lucy Shapiro, Andrew J. Spakowitz, and Harley H. McAdams

    PNAS January 29, 2013 110 (5) 1674-1679; https://doi.org/10.1073/pnas.1220824110
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    Frustration in the energy landscapes of multidomain protein misfolding

    Weihua Zheng, Nicholas P. Schafer, and Peter G. Wolynes

    PNAS January 29, 2013 110 (5) 1680-1685; https://doi.org/10.1073/pnas.1222130110
  • Open Access

    Minimization of thermodynamic costs in cancer cell invasion

    Liyu Liu, Guillaume Duclos, Bo Sun, Jeongseog Lee, Amy Wu, Yoonseok Kam, Eduardo D. Sontag, Howard A. Stone, James C. Sturm, Robert A. Gatenby, and Robert H. Austin

    PNAS January 29, 2013 110 (5) 1686-1691; https://doi.org/10.1073/pnas.1221147110
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    Buried lysine, but not arginine, titrates and alters transmembrane helix tilt

    Nicholas J. Gleason, Vitaly V. Vostrikov, Denise V. Greathouse, and Roger E. Koeppe II

    PNAS January 29, 2013 110 (5) 1692-1695; https://doi.org/10.1073/pnas.1215400110
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    Crystal structure of glycoprotein C from Rift Valley fever virus

    Moshe Dessau and Yorgo Modis

    PNAS January 29, 2013 110 (5) 1696-1701; https://doi.org/10.1073/pnas.1217780110
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    Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase

    Dmitry Lyumkis, Selom K. Doamekpor, Mario H. Bengtson, Joong-Won Lee, Tasha B. Toro, Matthew D. Petroski, Christopher D. Lima, Clinton S. Potter, Bridget Carragher, and Claudio A. P. Joazeiro

    PNAS January 29, 2013 110 (5) 1702-1707; https://doi.org/10.1073/pnas.1210041110

• Cell Biology

  • Open Access

    A kinase interacting protein (AKIP1) is a key regulator of cardiac stress

    Mira Sastri, Kristofer J. Haushalter, Mathivadhani Panneerselvam, Philip Chang, Heidi Fridolfsson, J. Cameron Finley, Daniel Ng, Jan M. Schilling, Atsushi Miyanohara, Michele E. Day, Hiro Hakozaki, Susanna Petrosyan, Antonius Koller, Charles C. King, Manjula Darshi, Donald K. Blumenthal, Sameh Saad Ali, David M. Roth, Hemal H. Patel, and Susan S. Taylor

    PNAS January 29, 2013 110 (5) E387-E396; https://doi.org/10.1073/pnas.1221670110

    See companion article:

    • PNAS Plus Significance Statements

      - Jan 29, 2013
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    Activation of NF-κB signalling by fusicoccin-induced dimerization

    Malgorzata Skwarczynska, Manuela Molzan, and Christian Ottmann

    PNAS January 29, 2013 110 (5) E377-E386; https://doi.org/10.1073/pnas.1212990110
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    NONO couples the circadian clock to the cell cycle

    • From the Cover

    Elzbieta Kowalska, Juergen A. Ripperger, Dominik C. Hoegger, Pascal Bruegger, Thorsten Buch, Thomas Birchler, Anke Mueller, Urs Albrecht, Claudio Contaldo, and Steven A. Brown

    PNAS January 29, 2013 110 (5) 1592-1599; https://doi.org/10.1073/pnas.1213317110

    See companion article:

    • A NONO-gate times the cell cycle

      - Jan 16, 2013
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    H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation

    Seung-Min Yang, Byung Ju Kim, Laura Norwood Toro, and Arthur I. Skoultchi

    PNAS January 29, 2013 110 (5) 1708-1713; https://doi.org/10.1073/pnas.1213266110
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    High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer

    Julia Izrailit, Hal K. Berman, Alessandro Datti, Jeffrey L. Wrana, and Michael Reedijk

    PNAS January 29, 2013 110 (5) 1714-1719; https://doi.org/10.1073/pnas.1214014110
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    RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development

    Wen-jing Su, Jun-shun Fang, Feng Cheng, Chao Liu, Fang Zhou, and Jian Zhang

    PNAS January 29, 2013 110 (5) 1720-1725; https://doi.org/10.1073/pnas.1211604110
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    Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

    Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Toshiaki Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi, and Takehiko Sasaki

    PNAS January 29, 2013 110 (5) 1726-1731; https://doi.org/10.1073/pnas.1213212110

• Developmental Biology

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    Reprogramming of adult rod photoreceptors prevents retinal degeneration

    Cynthia L. Montana, Alexander V. Kolesnikov, Susan Q. Shen, Connie A. Myers, Vladimir J. Kefalov, and Joseph C. Corbo

    PNAS January 29, 2013 110 (5) 1732-1737; https://doi.org/10.1073/pnas.1214387110
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    Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development

    Wei Li, Yiqin Xiong, Ching Shang, Karen Y. Twu, Calvin T. Hang, Jin Yang, Pei Han, Chieh-Yu Lin, Chien-Jung Lin, Feng-Chiao Tsai, Kryn Stankunas, Tobias Meyer, Daniel Bernstein, Minggui Pan, and Ching-Pin Chang

    PNAS January 29, 2013 110 (5) 1738-1743; https://doi.org/10.1073/pnas.1218072110

• Ecology

  • Open Access

    Plant invasions and extinction debts

    Benjamin Gilbert and Jonathan M. Levine

    PNAS January 29, 2013 110 (5) 1744-1749; https://doi.org/10.1073/pnas.1212375110
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    Centennial-scale fluctuations and regional complexity characterize Pacific salmon population dynamics over the past five centuries

    Lauren A. Rogers, Daniel E. Schindler, Peter J. Lisi, Gordon W. Holtgrieve, Peter R. Leavitt, Lynda Bunting, Bruce P. Finney, Daniel T. Selbie, Guangjie Chen, Irene Gregory-Eaves, Mark J. Lisac, and Patrick B. Walsh

    PNAS January 29, 2013 110 (5) 1750-1755; https://doi.org/10.1073/pnas.1212858110

• Environmental Sciences

  • Open Access

    Biogeochemistry of beetle-killed forests: Explaining a weak nitrate response

    Charles C. Rhoades, James H. McCutchan Jr., Leigh A. Cooper, David Clow, Thomas M. Detmer, Jennifer S. Briggs, John D. Stednick, Thomas T. Veblen, Rachel M. Ertz, Gene E. Likens, and William M. Lewis Jr.

    PNAS January 29, 2013 110 (5) 1756-1760; https://doi.org/10.1073/pnas.1221029110
  • Open Access

    Legacy of a half century of Athabasca oil sands development recorded by lake ecosystems

    • From the Cover

    Joshua Kurek, Jane L. Kirk, Derek C. G. Muir, Xiaowa Wang, Marlene S. Evans, and John P. Smol

    PNAS January 29, 2013 110 (5) 1761-1766; https://doi.org/10.1073/pnas.1217675110

    See companion article:

    • History of oil sands contamination

      - Jan 11, 2013
    • In This Issue

      - Jan 29, 2013

    See companion article:

    • Kurek et al. reply to Hrudey

      - May 29, 2013
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    SLC4 family transporters in a marine diatom directly pump bicarbonate from seawater

    Kensuke Nakajima, Atsuko Tanaka, and Yusuke Matsuda

    PNAS January 29, 2013 110 (5) 1767-1772; https://doi.org/10.1073/pnas.1216234110
  • Open Access

    Filling the Eastern European gap in millennium-long temperature reconstructions

    Ulf Büntgen, Tomáš Kyncl, Christian Ginzler, David S. Jacks, Jan Esper, Willy Tegel, Karl-Uwe Heussner, and Josef Kyncl

    PNAS January 29, 2013 110 (5) 1773-1778; https://doi.org/10.1073/pnas.1211485110
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    Frequency and intensity of productivity regime shifts in marine fish stocks

    Katyana A. Vert-pre, Ricardo O. Amoroso, Olaf P. Jensen, and Ray Hilborn

    PNAS January 29, 2013 110 (5) 1779-1784; https://doi.org/10.1073/pnas.1214879110

    See companion article:

    • Robust policies needed

      - Mar 27, 2013

• Evolution

  • Open Access

    Reference-assisted chromosome assembly

    Jaebum Kim, Denis M. Larkin, Qingle Cai, Asan, Yongfen Zhang, Ri-Li Ge, Loretta Auvil, Boris Capitanu, Guojie Zhang, Harris A. Lewin, and Jian Ma

    PNAS January 29, 2013 110 (5) 1785-1790; https://doi.org/10.1073/pnas.1220349110
  • Open Access

    Evolution of multicellularity coincided with increased diversification of cyanobacteria and the Great Oxidation Event

    Bettina E. Schirrmeister, Jurriaan M. de Vos, Alexandre Antonelli, and Homayoun C. Bagheri

    PNAS January 29, 2013 110 (5) 1791-1796; https://doi.org/10.1073/pnas.1209927110
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    Gene body methylation is conserved between plant orthologs and is of evolutionary consequence

    Shohei Takuno and Brandon S. Gaut

    PNAS January 29, 2013 110 (5) 1797-1802; https://doi.org/10.1073/pnas.1215380110

• Genetics

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    STOP gene Phactr4 is a tumor suppressor

    Nicole L. Solimini, Anthony C. Liang, Chunxiao Xu, Natalya N. Pavlova, Qikai Xu, Teresa Davoli, Mamie Z. Li, Kwok-Kin Wong, and Stephen J. Elledge

    PNAS January 29, 2013 110 (5) E407-E414; https://doi.org/10.1073/pnas.1221385110

    See companion article:

    • PNAS Plus Significance Statements

      - Jan 29, 2013
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    Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in Streptomyces

    Neil A. Holmes, John Walshaw, Richard M. Leggett, Annabelle Thibessard, Kate A. Dalton, Michael D. Gillespie, Andrew M. Hemmings, Bertolt Gust, and Gabriella H. Kelemen

    PNAS January 29, 2013 110 (5) E397-E406; https://doi.org/10.1073/pnas.1210657110
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    Genome-wide data substantiate Holocene gene flow from India to Australia

    Irina Pugach, Frederick Delfin, Ellen Gunnarsdóttir, Manfred Kayser, and Mark Stoneking

    PNAS January 29, 2013 110 (5) 1803-1808; https://doi.org/10.1073/pnas.1211927110

    See companion article:

    • Indian genes and Australian archaeological record

      - Jun 10, 2013

• Immunology

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    Role of the inflammasome in defense against venoms

    • From the Cover

    Noah W. Palm and Ruslan Medzhitov

    PNAS January 29, 2013 110 (5) 1809-1814; https://doi.org/10.1073/pnas.1221476110

    See companion article:

    • In This Issue

      - Jan 29, 2013
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    Inhibition of triple-negative breast cancer models by combinations of antibodies to EGFR

    Daniela A. Ferraro, Nadège Gaborit, Ruth Maron, Hadas Cohen-Dvashi, Ziv Porat, Fresia Pareja, Sara Lavi, Moshit Lindzen, Nir Ben-Chetrit, Michael Sela, and Yosef Yarden

    PNAS January 29, 2013 110 (5) 1815-1820; https://doi.org/10.1073/pnas.1220763110
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    Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration

    Stephane M. Caucheteux, Parizad Torabi-Parizi, and William E. Paul

    PNAS January 29, 2013 110 (5) 1821-1826; https://doi.org/10.1073/pnas.1221306110
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    Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

    Raju V. V. Tatituri, Gerald F. M. Watts, Veemal Bhowruth, Nathaniel Barton, Alissa Rothchild, Fong-Fu Hsu, Catarina F. Almeida, Liam R. Cox, Lothar Eggeling, Susanna Cardell, Jamie Rossjohn, Dale I. Godfrey, Samuel M. Behar, Gurdyal S. Besra, Michael B. Brenner, and Manfred Brigl

    PNAS January 29, 2013 110 (5) 1827-1832; https://doi.org/10.1073/pnas.1220601110
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    Aire’s plant homeodomain(PHD)-2 is critical for induction of immunological tolerance

    Siyoung Yang, Kushagra Bansal, Jared Lopes, Christophe Benoist, and Diane Mathis

    PNAS January 29, 2013 110 (5) 1833-1838; https://doi.org/10.1073/pnas.1222023110
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    Ecological analysis of antigen-specific CTL repertoires defines the relationship between naïve and immune T-cell populations

    Paul G. Thomas, Andreas Handel, Peter C. Doherty, and Nicole L. La Gruta

    PNAS January 29, 2013 110 (5) 1839-1844; https://doi.org/10.1073/pnas.1222149110
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    Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription

    Vaishali R. Moulton, Alexandros P. Grammatikos, Lisa M. Fitzgerald, and George C. Tsokos

    PNAS January 29, 2013 110 (5) 1845-1850; https://doi.org/10.1073/pnas.1214207110
  • Open Access

    Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

    Christopher L. Case, Lara J. Kohler, Jonilson B. Lima, Till Strowig, Marcel R. de Zoete, Richard A. Flavell, Dario S. Zamboni, and Craig R. Roy

    PNAS January 29, 2013 110 (5) 1851-1856; https://doi.org/10.1073/pnas.1211521110

• Medical Sciences

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    Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery

    Jarrod Predina, Evgeniy Eruslanov, Brendan Judy, Veena Kapoor, Guanjun Cheng, Liang-Chuan Wang, Jing Sun, Edmund K. Moon, Zvi Gregorio Fridlender, Steven Albelda, and Sunil Singhal

    PNAS January 29, 2013 110 (5) E415-E424; https://doi.org/10.1073/pnas.1211850110
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    Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors

    Livia S. Eberlin, Isaiah Norton, Daniel Orringer, Ian F. Dunn, Xiaohui Liu, Jennifer L. Ide, Alan K. Jarmusch, Keith L. Ligon, Ferenc A. Jolesz, Alexandra J. Golby, Sandro Santagata, Nathalie Y. R. Agar, and R. Graham Cooks

    PNAS January 29, 2013 110 (5) 1611-1616; https://doi.org/10.1073/pnas.1215687110

    See companion article:

    • In This Issue

      - Jan 29, 2013
  • Open Access

    Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene

    Melissa N. McCracken, Eric H. Gschweng, Evan Nair-Gill, Jami McLaughlin, Aaron R. Cooper, Mireille Riedinger, Donghui Cheng, Christopher Nosala, Donald B. Kohn, and Owen N. Witte

    PNAS January 29, 2013 110 (5) 1857-1862; https://doi.org/10.1073/pnas.1221840110
  • Open Access

    Antitumor activity of a pyrrole-imidazole polyamide

    Fei Yang, Nicholas G. Nickols, Benjamin C. Li, Georgi K. Marinov, Jonathan W. Said, and Peter B. Dervan

    PNAS January 29, 2013 110 (5) 1863-1868; https://doi.org/10.1073/pnas.1222035110
  • Open Access

    CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

    Jennifer L. Cantley, Toru Yoshimura, Joao Paulo G. Camporez, Dongyan Zhang, Francois R. Jornayvaz, Naoki Kumashiro, Fitsum Guebre-Egziabher, Michael J. Jurczak, Mario Kahn, Blas A. Guigni, Julie Serr, Joseph Hankin, Robert C. Murphy, Gary W. Cline, Sanjay Bhanot, Vara Prasad Manchem, J. Mark Brown, Varman T. Samuel, and Gerald I. Shulman

    PNAS January 29, 2013 110 (5) 1869-1874; https://doi.org/10.1073/pnas.1219456110
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    Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

    Yoko Hosaka, Taku Saito, Shurei Sugita, Tomohiro Hikata, Hiroshi Kobayashi, Atsushi Fukai, Yuki Taniguchi, Makoto Hirata, Haruhiko Akiyama, Ung-il Chung, and Hiroshi Kawaguchi

    PNAS January 29, 2013 110 (5) 1875-1880; https://doi.org/10.1073/pnas.1207458110

• Microbiology

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    Competing and noncompeting activities of miR-122 and the 5′ exonuclease Xrn1 in regulation of hepatitis C virus replication

    • From the Cover

    You Li, Takahiro Masaki, Daisuke Yamane, David R. McGivern, and Stanley M. Lemon

    PNAS January 29, 2013 110 (5) 1881-1886; https://doi.org/10.1073/pnas.1213515110

    See companion article:

    • Hepatitis C virus and miR-122

      - Jan 16, 2013
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    Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity

    Guozhong Huang, Paula J. Bartlett, Andrew P. Thomas, Silvia N. J. Moreno, and Roberto Docampo

    PNAS January 29, 2013 110 (5) 1887-1892; https://doi.org/10.1073/pnas.1216955110
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    Antibodies are necessary for rVSV/ZEBOV-GP–mediated protection against lethal Ebola virus challenge in nonhuman primates

    Andrea Marzi, Flora Engelmann, Friederike Feldmann, Kristen Haberthur, W. Lesley Shupert, Douglas Brining, Dana P. Scott, Thomas W. Geisbert, Yoshihiro Kawaoka, Michael G. Katze, Heinz Feldmann, and Ilhem Messaoudi

    PNAS January 29, 2013 110 (5) 1893-1898; https://doi.org/10.1073/pnas.1209591110
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    Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors

    Yuan-Ju Wu, Herbert Schulz, Chia-Ching Lin, Kathrin Saar, Giannino Patone, Heike Fischer, Norbert Hübner, Bernd Heimrich, and Martin Schwemmle

    PNAS January 29, 2013 110 (5) 1899-1904; https://doi.org/10.1073/pnas.1214939110
  • Open Access

    Structure of the trypanosome haptoglobin–hemoglobin receptor and implications for nutrient uptake and innate immunity

    Matthew K. Higgins, Olga Tkachenko, Alan Brown, Jenny Reed, Jayne Raper, and Mark Carrington

    PNAS January 29, 2013 110 (5) 1905-1910; https://doi.org/10.1073/pnas.1214943110
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    An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis

    Stefan L. Oliver, Jennifer J. Brady, Marvin H. Sommer, Mike Reichelt, Phillip Sung, Helen M. Blau, and Ann M. Arvin

    PNAS January 29, 2013 110 (5) 1911-1916; https://doi.org/10.1073/pnas.1216985110

• Neuroscience

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    Using model-based functional MRI to locate working memory updates and declarative memory retrievals in the fronto-parietal network

    Jelmer P. Borst and John R. Anderson

    PNAS January 29, 2013 110 (5) 1628-1633; https://doi.org/10.1073/pnas.1221572110
  • Open Access

    Physical activity and obesity mediate the association between childhood motor function and adolescents’ academic achievement

    Marko T. Kantomaa, Emmanuel Stamatakis, Anna Kankaanpää, Marika Kaakinen, Alina Rodriguez, Anja Taanila, Timo Ahonen, Marjo-Riitta Järvelin, and Tuija Tammelin

    PNAS January 29, 2013 110 (5) 1917-1922; https://doi.org/10.1073/pnas.1214574110

    See companion article:

    • In This Issue

      - Jan 29, 2013
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    ∆FosB differentially modulates nucleus accumbens direct and indirect pathway function

    Brad A. Grueter, Alfred J. Robison, Rachael L. Neve, Eric J. Nestler, and Robert C. Malenka

    PNAS January 29, 2013 110 (5) 1923-1928; https://doi.org/10.1073/pnas.1221742110
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    Coupling of functional connectivity and regional cerebral blood flow reveals a physiological basis for network hubs of the human brain

    Xia Liang, Qihong Zou, Yong He, and Yihong Yang

    PNAS January 29, 2013 110 (5) 1929-1934; https://doi.org/10.1073/pnas.1214900110
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    Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons

    Erik Keimpema, Giuseppe Tortoriello, Alán Alpár, Simona Capsoni, Ivan Arisi, Daniela Calvigioni, Sherry Shu-Jung Hu, Antonino Cattaneo, Patrick Doherty, Kenneth Mackie, and Tibor Harkany

    PNAS January 29, 2013 110 (5) 1935-1940; https://doi.org/10.1073/pnas.1212563110
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    Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology

    Jean-Philippe Michaud, Maxime Hallé, Antoine Lampron, Peter Thériault, Paul Préfontaine, Mohammed Filali, Pascale Tribout-Jover, Anne-Marie Lanteigne, Rachel Jodoin, Christopher Cluff, Vincent Brichard, Rémi Palmantier, Anthony Pilorget, Daniel Larocque, and Serge Rivest

    PNAS January 29, 2013 110 (5) 1941-1946; https://doi.org/10.1073/pnas.1215165110

• Plant Biology

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    Transcriptional responses of Pseudomonas syringae to growth in epiphytic versus apoplastic leaf sites

    Xilan Yu, Steven P. Lund, Russell A. Scott, Jessica W. Greenwald, Angela H. Records, Dan Nettleton, Steven E. Lindow, Dennis C. Gross, and Gwyn A. Beattie

    PNAS January 29, 2013 110 (5) E425-E434; https://doi.org/10.1073/pnas.1221892110

    See companion article:

    • PNAS Plus Significance Statements

      - Jan 29, 2013
  • Open Access

    Comprehensive developmental profiles of gene activity in regions and subregions of the Arabidopsis seed

    Mark F. Belmonte, Ryan C. Kirkbride, Sandra L. Stone, Julie M. Pelletier, Anhthu Q. Bui, Edward C. Yeung, Meryl Hashimoto, Jiong Fei, Corey M. Harada, Matthew D. Munoz, Brandon H. Le, Gary N. Drews, Siobhan M. Brady, Robert B. Goldberg, and John J. Harada

    PNAS January 29, 2013 110 (5) E435-E444; https://doi.org/10.1073/pnas.1222061110

    See companion article:

    • PNAS Plus Significance Statements

      - Jan 29, 2013
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    CYP714B1 and CYP714B2 encode gibberellin 13-oxidases that reduce gibberellin activity in rice

    Hiroshi Magome, Takahito Nomura, Atsushi Hanada, Noriko Takeda-Kamiya, Toshiyuki Ohnishi, Yuko Shinma, Takumi Katsumata, Hiroshi Kawaide, Yuji Kamiya, and Shinjiro Yamaguchi

    PNAS January 29, 2013 110 (5) 1947-1952; https://doi.org/10.1073/pnas.1215788110
  • Open Access

    Control of transposon activity by a histone H3K4 demethylase in rice

    Xiekui Cui, Ping Jin, Xia Cui, Lianfeng Gu, Zhike Lu, Yongming Xue, Liya Wei, Jianfei Qi, Xianwei Song, Ming Luo, Gynheung An, and Xiaofeng Cao

    PNAS January 29, 2013 110 (5) 1953-1958; https://doi.org/10.1073/pnas.1217020110

• Psychological and Cognitive Sciences

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    Monkeys are perceptually tuned to facial expressions that exhibit a theta-like speech rhythm

    Asif A. Ghazanfar, Ryan J. Morrill, and Christoph Kayser

    PNAS January 29, 2013 110 (5) 1959-1963; https://doi.org/10.1073/pnas.1214956110

• Systems Biology

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    Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action

    Sheng-hong Chen, Kiriko Masuno, Samantha B. Cooper, and Keith R. Yamamoto

    PNAS January 29, 2013 110 (5) 1964-1969; https://doi.org/10.1073/pnas.1216108110