Table of Contents

Biological Sciences

• Agricultural Sciences

  • Open Access

    Increasing homogeneity in global food supplies and the implications for food security

    Colin K. Khoury, Anne D. Bjorkman, Hannes Dempewolf, Julian Ramirez-Villegas, Luigi Guarino, Andy Jarvis, Loren H. Rieseberg, and Paul C. Struik

    PNAS March 18, 2014 111 (11) 4001-4006; https://doi.org/10.1073/pnas.1313490111

• Biochemistry

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    Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner

    Rajas Chodankar, Dai-Ying Wu, Benjamin J. Schiller, Keith R. Yamamoto, and Michael R. Stallcup

    PNAS March 18, 2014 111 (11) 4007-4012; https://doi.org/10.1073/pnas.1400522111
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    Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

    Kent E. S. Matlack, Daniel F. Tardiff, Priyanka Narayan, Shusei Hamamichi, Kim A. Caldwell, Guy A. Caldwell, and Susan Lindquist

    PNAS March 18, 2014 111 (11) 4013-4018; https://doi.org/10.1073/pnas.1402228111
  • Open Access

    Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

    Christoph Loenarz, Rok Sekirnik, Armin Thalhammer, Wei Ge, Ekaterina Spivakovsky, Mukram M. Mackeen, Michael A. McDonough, Matthew E. Cockman, Benedikt M. Kessler, Peter J. Ratcliffe, Alexander Wolf, and Christopher J. Schofield

    PNAS March 18, 2014 111 (11) 4019-4024; https://doi.org/10.1073/pnas.1311750111

    See companion article:

    • Prolyl hydroxylation of RPS23 by OGFOD1

      - Feb 18, 2014
    • Drosophila ribosomal protein hydroxylation

      - Feb 18, 2014
  • Open Access

    Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth

    Maximiliano J. Katz, Julieta M. Acevedo, Christoph Loenarz, Diego Galagovsky, Phebee Liu-Yi, Marcelo Pérez-Pepe, Armin Thalhammer, Rok Sekirnik, Wei Ge, Mariana Melani, María G. Thomas, Sergio Simonetta, Graciela L. Boccaccio, Christopher J. Schofield, Matthew E. Cockman, Peter J. Ratcliffe, and Pablo Wappner

    PNAS March 18, 2014 111 (11) 4025-4030; https://doi.org/10.1073/pnas.1314485111

    See companion article:

    • Prolyl hydroxylation of RPS23 by OGFOD1

      - Feb 18, 2014
    • Ribosome hydroxylation and translation termination

      - Feb 18, 2014
  • Open Access

    OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

    Rachelle S. Singleton, Phebee Liu-Yi, Fabio Formenti, Wei Ge, Rok Sekirnik, Roman Fischer, Julie Adam, Patrick J. Pollard, Alexander Wolf, Armin Thalhammer, Christoph Loenarz, Emily Flashman, Atsushi Yamamoto, Mathew L. Coleman, Benedikt M. Kessler, Pablo Wappner, Christopher J. Schofield, Peter J. Ratcliffe, and Matthew E. Cockman

    PNAS March 18, 2014 111 (11) 4031-4036; https://doi.org/10.1073/pnas.1314482111

    See companion article:

    • Drosophila ribosomal protein hydroxylation

      - Feb 18, 2014
    • Ribosome hydroxylation and translation termination

      - Feb 18, 2014
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    Stalled transcription complexes promote DNA repair at a distance

    • From the Cover

    Nia M. Haines, Young-In T. Kim, Abigail J. Smith, and Nigel J. Savery

    PNAS March 18, 2014 111 (11) 4037-4042; https://doi.org/10.1073/pnas.1322350111

    See companion article:

    • Pausing to scout ahead for damage

      - Mar 05, 2014
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    Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2

    Catherine B. Poor, Seraphine V. Wegner, Haoran Li, Adrienne C. Dlouhy, Jonathan P. Schuermann, Ruslan Sanishvili, James R. Hinshaw, Pamela J. Riggs-Gelasco, Caryn E. Outten, and Chuan He

    PNAS March 18, 2014 111 (11) 4043-4048; https://doi.org/10.1073/pnas.1318869111
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    Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

    Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Sakiyama, Christopher J. Hipolito, Akane Fujioka, Ryo Hirokane, Keiji Ikeguchi, Bunta Watanabe, Jun Hiratake, Yasuhisa Kimura, Hiroaki Suga, Kazumitsu Ueda, and Hiroaki Kato

    PNAS March 18, 2014 111 (11) 4049-4054; https://doi.org/10.1073/pnas.1321562111
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    Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain

    Jingling Liao, Chun-Xiang Wu, Christopher Burlak, Sheng Zhang, Heather Sahm, Mu Wang, Zhong-Yin Zhang, Kurt W. Vogel, Mark Federici, Steve M. Riddle, R. Jeremy Nichols, Dali Liu, Mark R. Cookson, Todd A. Stone, and Quyen Q. Hoang

    PNAS March 18, 2014 111 (11) 4055-4060; https://doi.org/10.1073/pnas.1323285111
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    Redesign of extensive protein–DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization

    Ryo Takeuchi, Michael Choi, and Barry L. Stoddard

    PNAS March 18, 2014 111 (11) 4061-4066; https://doi.org/10.1073/pnas.1321030111

• Biophysics and Computational Biology

  • Open Access

    In vivo X-ray cine-tomography for tracking morphological dynamics

    Tomy dos Santos Rolo, Alexey Ershov, Thomas van de Kamp, and Tilo Baumbach

    PNAS March 18, 2014 111 (11) 3921-3926; https://doi.org/10.1073/pnas.1308650111
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    Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus

    Daniel Reker, Tiago Rodrigues, Petra Schneider, and Gisbert Schneider

    PNAS March 18, 2014 111 (11) 4067-4072; https://doi.org/10.1073/pnas.1320001111
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    Single-molecule studies of polymerase dynamics and stoichiometry at the bacteriophage T7 replication machinery

    Hylkje J. Geertsema, Arkadiusz W. Kulczyk, Charles C. Richardson, and Antoine M. van Oijen

    PNAS March 18, 2014 111 (11) 4073-4078; https://doi.org/10.1073/pnas.1402010111
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    Graph-based sampling for approximating global helical topologies of RNA

    Namhee Kim, Christian Laing, Shereef Elmetwaly, Segun Jung, Jeremy Curuksu, and Tamar Schlick

    PNAS March 18, 2014 111 (11) 4079-4084; https://doi.org/10.1073/pnas.1318893111
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    Strength of a bifurcated H bond

    Esther S. Feldblum and Isaiah T. Arkin

    PNAS March 18, 2014 111 (11) 4085-4090; https://doi.org/10.1073/pnas.1319827111
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    Myosin lever arm directs collective motion on cellular actin network

    Rizal F. Hariadi, Mario Cale, and Sivaraj Sivaramakrishnan

    PNAS March 18, 2014 111 (11) 4091-4096; https://doi.org/10.1073/pnas.1315923111
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    Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code

    Meng S. Choy, Martina Hieke, Ganesan Senthil Kumar, Greyson R. Lewis, Kristofer R. Gonzalez-DeWhitt, Rene P. Kessler, Benjamin J. Stein, Manuel Hessenberger, Angus C. Nairn, Wolfgang Peti, and Rebecca Page

    PNAS March 18, 2014 111 (11) 4097-4102; https://doi.org/10.1073/pnas.1317395111

• Cell Biology

  • Open Access

    Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis

    Masashi Maekawa, Shimpei Terasaka, Yasuhiro Mochizuki, Katsuhisa Kawai, Yuka Ikeda, Nobukazu Araki, Edward Y. Skolnik, Tomohiko Taguchi, and Hiroyuki Arai

    PNAS March 18, 2014 111 (11) E978-E987; https://doi.org/10.1073/pnas.1311029111
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    Three-dimensional cell migration does not follow a random walk

    Pei-Hsun Wu, Anjil Giri, Sean X. Sun, and Denis Wirtz

    PNAS March 18, 2014 111 (11) 3949-3954; https://doi.org/10.1073/pnas.1318967111
  • Open Access

    Transcriptional divergence and conservation of human and mouse erythropoiesis

    Novalia Pishesha, Prathapan Thiru, Jiahai Shi, Jennifer C. Eng, Vijay G. Sankaran, and Harvey F. Lodish

    PNAS March 18, 2014 111 (11) 4103-4108; https://doi.org/10.1073/pnas.1401598111
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    Requirement of MEF2A, C, and D for skeletal muscle regeneration

    Ning Liu, Benjamin R. Nelson, Svetlana Bezprozvannaya, John M. Shelton, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson

    PNAS March 18, 2014 111 (11) 4109-4114; https://doi.org/10.1073/pnas.1401732111
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    BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy

    Salwa Sebti, Christine Prébois, Esther Pérez-Gracia, Chantal Bauvy, Fabienne Desmots, Nelly Pirot, Céline Gongora, Anne-Sophie Bach, Andrew V. Hubberstey, Valérie Palissot, Guy Berchem, Patrice Codogno, Laetitia K. Linares, Emmanuelle Liaudet-Coopman, and Sophie Pattingre

    PNAS March 18, 2014 111 (11) 4115-4120; https://doi.org/10.1073/pnas.1313618111
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    Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin

    Jonathan D. Winkelman, Colleen G. Bilancia, Mark Peifer, and David R. Kovar

    PNAS March 18, 2014 111 (11) 4121-4126; https://doi.org/10.1073/pnas.1322093111
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    Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates

    Roland Thuenauer, Ya-Chu Hsu, Jose Maria Carvajal-Gonzalez, Sylvie Deborde, Jen-Zen Chuang, Winfried Römer, Alois Sonnleitner, Enrique Rodriguez-Boulan, and Ching-Hwa Sung

    PNAS March 18, 2014 111 (11) 4127-4132; https://doi.org/10.1073/pnas.1304168111

• Developmental Biology

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    BMP signaling is required for the generation of primordial germ cells in an insect

    Seth Donoughe, Taro Nakamura, Ben Ewen-Campen, Delbert A. Green II, Lory Henderson, and Cassandra G. Extavour

    PNAS March 18, 2014 111 (11) 4133-4138; https://doi.org/10.1073/pnas.1400525111
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    Fine mapping of genome activation in bovine embryos by RNA sequencing

    Alexander Graf, Stefan Krebs, Valeri Zakhartchenko, Björn Schwalb, Helmut Blum, and Eckhard Wolf

    PNAS March 18, 2014 111 (11) 4139-4144; https://doi.org/10.1073/pnas.1321569111
  • Open Access

    Seminal vesicle protein SVS2 is required for sperm survival in the uterus

    Natsuko Kawano, Naoya Araki, Kaoru Yoshida, Taku Hibino, Naoko Ohnami, Maako Makino, Seiya Kanai, Hidetoshi Hasuwa, Manabu Yoshida, Kenji Miyado, and Akihiro Umezawa

    PNAS March 18, 2014 111 (11) 4145-4150; https://doi.org/10.1073/pnas.1320715111

• Ecology

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    Chemical defenses and resource trade-offs structure sponge communities on Caribbean coral reefs

    • From the Cover

    Tse-Lynn Loh and Joseph R. Pawlik

    PNAS March 18, 2014 111 (11) 4151-4156; https://doi.org/10.1073/pnas.1321626111
  • Open Access

    Evidence that dimethyl sulfide facilitates a tritrophic mutualism between marine primary producers and top predators

    Matthew S. Savoca and Gabrielle A. Nevitt

    PNAS March 18, 2014 111 (11) 4157-4161; https://doi.org/10.1073/pnas.1317120111
  • Open Access

    High herbivore density associated with vegetation diversity in interglacial ecosystems

    Christopher J. Sandom, Rasmus Ejrnæs, Morten D. D. Hansen, and Jens-Christian Svenning

    PNAS March 18, 2014 111 (11) 4162-4167; https://doi.org/10.1073/pnas.1311014111

• Evolution

  • Open Access

    Oxygen requirements of the earliest animals

    • From the Cover

    Daniel B. Mills, Lewis M. Ward, CarriAyne Jones, Brittany Sweeten, Michael Forth, Alexander H. Treusch, and Donald E. Canfield

    PNAS March 18, 2014 111 (11) 4168-4172; https://doi.org/10.1073/pnas.1400547111

    See companion article:

    • Oxygen and animals

      - Mar 10, 2014

• Genetics

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    Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5

    Taewan Kim, Ri Cui, Young-Jun Jeon, Ji-Hoon Lee, Ju Hee Lee, Hosung Sim, Jong Kook Park, Paolo Fadda, Esmerina Tili, Hiroshi Nakanishi, Man-Il Huh, Sung-Hak Kim, Ju Hwan Cho, Bong Hwan Sung, Yong Peng, Tae Jin Lee, Zhenghua Luo, Hui-Lung Sun, Huijun Wei, Hansjuerg Alder, Jeong Su Oh, Kang Sup Shim, Sang-Bong Ko, and Carlo M. Croce

    PNAS March 18, 2014 111 (11) 4173-4178; https://doi.org/10.1073/pnas.1400350111
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    NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation

    Ann-Kathrin Eisfeld, Sebastian Schwind, Kevin W. Hoag, Christopher J. Walker, Sandya Liyanarachchi, Ravi Patel, Xiaomeng Huang, Joseph Markowitz, Wenrui Duan, Gregory A. Otterson, William E. Carson III, Guido Marcucci, Clara D. Bloomfield, and Albert de la Chapelle

    PNAS March 18, 2014 111 (11) 4179-4184; https://doi.org/10.1073/pnas.1401727111
  • Open Access

    Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast

    Beate Schwer, Danny Asher Bitton, Ana M. Sanchez, Jürg Bähler, and Stewart Shuman

    PNAS March 18, 2014 111 (11) 4185-4190; https://doi.org/10.1073/pnas.1321842111
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    G-protein–coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion

    Michael E. Feigin, Bin Xue, Molly C. Hammell, and Senthil K. Muthuswamy

    PNAS March 18, 2014 111 (11) 4191-4196; https://doi.org/10.1073/pnas.1320239111
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    Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

    Vasyl Nesin, Graham Wiley, Maria Kousi, E-Ching Ong, Thomas Lehmann, David J. Nicholl, Mohnish Suri, Nortina Shahrizaila, Nicholas Katsanis, Patrick M. Gaffney, Klaas J. Wierenga, and Leonidas Tsiokas

    PNAS March 18, 2014 111 (11) 4197-4202; https://doi.org/10.1073/pnas.1312520111

• Immunology

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    Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination

    Astrid Zahn, Anil K. Eranki, Anne-Marie Patenaude, Stephen P. Methot, Heather Fifield, Elena M. Cortizas, Paul Foster, Kohsuke Imai, Anne Durandy, Mani Larijani, Ramiro E. Verdun, and Javier M. Di Noia

    PNAS March 18, 2014 111 (11) E988-E997; https://doi.org/10.1073/pnas.1320486111
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    Dendritic cell fate is determined by BCL11A

    Gregory C. Ippolito, Joseph D. Dekker, Yui-Hsi Wang, Bum-Kyu Lee, Arthur L. Shaffer III, Jian Lin, Jason K. Wall, Baeck-Seung Lee, Louis M. Staudt, Yong-Jun Liu, Vishwanath R. Iyer, and Haley O. Tucker

    PNAS March 18, 2014 111 (11) E998-E1006; https://doi.org/10.1073/pnas.1319228111
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    Duality of the murine CD8 compartment

    Raphaël Genolet, Julie Leignadier, Magne Østerås, Laurent Farinelli, Brian J. Stevenson, and Immanuel F. Luescher

    PNAS March 18, 2014 111 (11) E1007-E1015; https://doi.org/10.1073/pnas.1317847111
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    Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase

    Ashraf S. Yousif, Andre Stanlie, Samiran Mondal, Tasuku Honjo, and Nasim A. Begum

    PNAS March 18, 2014 111 (11) E1016-E1024; https://doi.org/10.1073/pnas.1402391111
  • Open Access

    TGF-β–inducible microRNA-183 silences tumor-associated natural killer cells

    Sarah S. Donatelli, Jun-Min Zhou, Danielle L. Gilvary, Erika A. Eksioglu, Xianghong Chen, W. Douglas Cress, Eric B. Haura, Matthew B. Schabath, Domenico Coppola, Sheng Wei, and Julie Y. Djeu

    PNAS March 18, 2014 111 (11) 4203-4208; https://doi.org/10.1073/pnas.1319269111
  • Open Access

    C1q as a unique player in angiogenesis with therapeutic implication in wound healing

    Fleur Bossi, Claudio Tripodo, Lucia Rizzi, Roberta Bulla, Chiara Agostinis, Carla Guarnotta, Carine Munaut, Gustavo Baldassarre, Giovanni Papa, Sonia Zorzet, Berhane Ghebrehiwet, Guang Sheng Ling, Marina Botto, and Francesco Tedesco

    PNAS March 18, 2014 111 (11) 4209-4214; https://doi.org/10.1073/pnas.1311968111
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    Marginal zone CD169⁺ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance

    Buvana Ravishankar, Rahul Shinde, Haiyun Liu, Kapil Chaudhary, Jillian Bradley, Henrique P. Lemos, Phillip Chandler, Masato Tanaka, David H. Munn, Andrew L. Mellor, and Tracy L. McGaha

    PNAS March 18, 2014 111 (11) 4215-4220; https://doi.org/10.1073/pnas.1320924111
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    Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients

    Wen-Chao Wu, Hong-Wei Sun, Hai-Tian Chen, Jing Liang, Xing-Juan Yu, Chong Wu, Zilian Wang, and Limin Zheng

    PNAS March 18, 2014 111 (11) 4221-4226; https://doi.org/10.1073/pnas.1320753111

• Medical Sciences

  • Open Access

    Binding of Pro-Gly-Pro at the active site of leukotriene A₄ hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

    Alena Stsiapanava, Ulrika Olsson, Min Wan, Thea Kleinschmidt, Dorothea Rutishauser, Roman A. Zubarev, Bengt Samuelsson, Agnes Rinaldo-Matthis, and Jesper Z. Haeggström

    PNAS March 18, 2014 111 (11) 4227-4232; https://doi.org/10.1073/pnas.1402136111
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    Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer

    Lindsey M. Kelly, Guillermo Barila, Pengyuan Liu, Viktoria N. Evdokimova, Sumita Trivedi, Federica Panebianco, Manoj Gandhi, Sally E. Carty, Steven P. Hodak, Jianhua Luo, Sanja Dacic, Yan P. Yu, Marina N. Nikiforova, Robert L. Ferris, Daniel L. Altschuler, and Yuri E. Nikiforov

    PNAS March 18, 2014 111 (11) 4233-4238; https://doi.org/10.1073/pnas.1321937111
  • Open Access

    Tumor suppressor role of phospholipase Cε in Ras-triggered cancers

    Marta Martins, Afshan McCarthy, Rhona Baxendale, Sabrina Guichard, Lorenza Magno, Nicoletta Kessaris, Mona El-Bahrawy, Philipp Yu, and Matilda Katan

    PNAS March 18, 2014 111 (11) 4239-4244; https://doi.org/10.1073/pnas.1311500111
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    Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media

    Jillian E. Tengood, Ivan S. Alferiev, Kehan Zhang, Ilia Fishbein, Robert J. Levy, and Michael Chorny

    PNAS March 18, 2014 111 (11) 4245-4250; https://doi.org/10.1073/pnas.1324104111
  • Open Access

    Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer

    Shan Wang, Rahul K. Kollipara, Nishi Srivastava, Rui Li, Preethi Ravindranathan, Elizabeth Hernandez, Eva Freeman, Caroline G. Humphries, Payal Kapur, Yair Lotan, Ladan Fazli, Martin E. Gleave, Stephen R. Plymate, Ganesh V. Raj, Jer-Tsong Hsieh, and Ralf Kittler

    PNAS March 18, 2014 111 (11) 4251-4256; https://doi.org/10.1073/pnas.1322198111

• Microbiology

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    Rod-like bacterial shape is maintained by feedback between cell curvature and cytoskeletal localization

    Tristan S. Ursell, Jeffrey Nguyen, Russell D. Monds, Alexandre Colavin, Gabriel Billings, Nikolay Ouzounov, Zemer Gitai, Joshua W. Shaevitz, and Kerwyn Casey Huang

    PNAS March 18, 2014 111 (11) E1025-E1034; https://doi.org/10.1073/pnas.1317174111
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    A soil actinobacterium scavenges atmospheric H₂ using two membrane-associated, oxygen-dependent [NiFe] hydrogenases

    Chris Greening, Michael Berney, Kiel Hards, Gregory M. Cook, and Ralf Conrad

    PNAS March 18, 2014 111 (11) 4257-4261; https://doi.org/10.1073/pnas.1320586111
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    microRNAs are biomarkers of oncogenic human papillomavirus infections

    Xiaohong Wang, Hsu-Kun Wang, Yang Li, Markus Hafner, Nilam Sanjib Banerjee, Shuang Tang, Daniel Briskin, Craig Meyers, Louise T. Chow, Xing Xie, Thomas Tuschl, and Zhi-Ming Zheng

    PNAS March 18, 2014 111 (11) 4262-4267; https://doi.org/10.1073/pnas.1401430111
  • Open Access

    Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota

    Yijun Zhu, Eleanor Jameson, Marialuisa Crosatti, Hendrik Schäfer, Kumar Rajakumar, Timothy D. H. Bugg, and Yin Chen

    PNAS March 18, 2014 111 (11) 4268-4273; https://doi.org/10.1073/pnas.1316569111
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    Thirty-thousand-year-old distant relative of giant icosahedral DNA viruses with a pandoravirus morphology

    Matthieu Legendre, Julia Bartoli, Lyubov Shmakova, Sandra Jeudy, Karine Labadie, Annie Adrait, Magali Lescot, Olivier Poirot, Lionel Bertaux, Christophe Bruley, Yohann Couté, Elizaveta Rivkina, Chantal Abergel, and Jean-Michel Claverie

    PNAS March 18, 2014 111 (11) 4274-4279; https://doi.org/10.1073/pnas.1320670111
  • Open Access

    Combinatorial quorum sensing allows bacteria to resolve their social and physical environment

    Daniel M. Cornforth, Roman Popat, Luke McNally, James Gurney, Thomas C. Scott-Phillips, Alasdair Ivens, Stephen P. Diggle, and Sam P. Brown

    PNAS March 18, 2014 111 (11) 4280-4284; https://doi.org/10.1073/pnas.1319175111
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    Structural basis of Flavivirus NS1 assembly and antibody recognition

    Melissa A. Edeling, Michael S. Diamond, and Daved H. Fremont

    PNAS March 18, 2014 111 (11) 4285-4290; https://doi.org/10.1073/pnas.1322036111
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    Gene silencing and gene expression in phytopathogenic fungi using a plant virus vector

    Tiziana Mascia, Franco Nigro, Alì Abdallah, Massimo Ferrara, Angelo De Stradis, Roberto Faedda, Peter Palukaitis, and Donato Gallitelli

    PNAS March 18, 2014 111 (11) 4291-4296; https://doi.org/10.1073/pnas.1315668111

• Neuroscience

  • Open Access

    Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

    Ethan A. Winkler, Jesse D. Sengillo, Abhay P. Sagare, Zhen Zhao, Qingyi Ma, Edward Zuniga, Yaoming Wang, Zhihui Zhong, John S. Sullivan, John H. Griffin, Don W. Cleveland, and Berislav V. Zlokovic

    PNAS March 18, 2014 111 (11) E1035-E1042; https://doi.org/10.1073/pnas.1401595111
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    Identification of ocular dominance domains in New World owl monkeys by immediate-early gene expression

    Toru Takahata, Masanobu Miyashita, Shigeru Tanaka, and Jon H. Kaas

    PNAS March 18, 2014 111 (11) 4297-4302; https://doi.org/10.1073/pnas.1401951111
  • Open Access

    Mossy fiber-evoked subthreshold responses induce timing-dependent plasticity at hippocampal CA3 recurrent synapses

    Federico Brandalise and Urs Gerber

    PNAS March 18, 2014 111 (11) 4303-4308; https://doi.org/10.1073/pnas.1317667111
  • Open Access

    Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

    James A. Austin, Gareth S. A. Wright, Seiji Watanabe, J. Günter Grossmann, Svetlana V. Antonyuk, Koji Yamanaka, and S. Samar Hasnain

    PNAS March 18, 2014 111 (11) 4309-4314; https://doi.org/10.1073/pnas.1317317111
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    Memory loss in a nonnavigational spatial task after hippocampal inactivation in monkeys

    Patrick A. Forcelli, Guillermo Palchik, Taylor Leath, Jacqueline T. DesJardin, Karen Gale, and Ludise Malkova

    PNAS March 18, 2014 111 (11) 4315-4320; https://doi.org/10.1073/pnas.1320562111
  • Open Access

    Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors

    Natalia V. Luchkina, Johanna Huupponen, Vernon R. J. Clarke, Sarah K. Coleman, Kari Keinänen, Tomi Taira, and Sari E. Lauri

    PNAS March 18, 2014 111 (11) 4321-4326; https://doi.org/10.1073/pnas.1315769111

• Physiology

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    Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

    Milène Catoire, Sheril Alex, Nicolas Paraskevopulos, Frits Mattijssen, Inkie Evers-van Gogh, Gert Schaart, Jacob Jeppesen, Anita Kneppers, Marco Mensink, Peter J. Voshol, Gunilla Olivecrona, Nguan Soon Tan, Matthijs K. C. Hesselink, Jimmy F. Berbée, Patrick C. N. Rensen, Eric Kalkhoven, Patrick Schrauwen, and Sander Kersten

    PNAS March 18, 2014 111 (11) E1043-E1052; https://doi.org/10.1073/pnas.1400889111

• Plant Biology

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    Endogenous localizome identifies 43 mitotic kinesins in a plant cell

    Tomohiro Miki, Haruko Naito, Momoko Nishina, and Gohta Goshima

    PNAS March 18, 2014 111 (11) E1053-E1061; https://doi.org/10.1073/pnas.1311243111
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    Ethylene-orchestrated circuitry coordinates a seedling’s response to soil cover and etiolated growth

    • Inaugural Article

    Shangwei Zhong, Hui Shi, Chang Xue, Ning Wei, Hongwei Guo, and Xing Wang Deng

    PNAS March 18, 2014 111 (11) 3913-3920; https://doi.org/10.1073/pnas.1402491111
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    Actin-dependent plastid movement is required for motive force generation in directional nuclear movement in plants

    Takeshi Higa, Noriyuki Suetsugu, Sam-Geun Kong, and Masamitsu Wada

    PNAS March 18, 2014 111 (11) 4327-4331; https://doi.org/10.1073/pnas.1317902111

• Sustainability Science

  • Open Access

    Quantifying causal mechanisms to determine how protected areas affect poverty through changes in ecosystem services and infrastructure

    • From the Cover

    Paul J. Ferraro and Merlin M. Hanauer

    PNAS March 18, 2014 111 (11) 4332-4337; https://doi.org/10.1073/pnas.1307712111

    See companion article:

    • Matching and causal mechanisms

      - Mar 05, 2014

• Systems Biology

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    Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode

    Praveen Agrawal, Tomasz Kurcon, Kanoelani T. Pilobello, John F. Rakus, Sujeethraj Koppolu, Zhongyin Liu, Bianca S. Batista, William S. Eng, Ku-Lung Hsu, Yaxuan Liang, and Lara K. Mahal

    PNAS March 18, 2014 111 (11) 4338-4343; https://doi.org/10.1073/pnas.1321524111