Proceedings of the National Academy of Sciences: 111 (11)

New Research In

March 18, 2014; vol. 111 no. 11

This Week in PNAS

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In This Issue
PNAS March 18, 2014 111 (11) 3897-3898; https://doi.org/10.1073/iti1114111

Letters (Online Only)

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Distinguishing constitutional and acquired nonclonal aneuploidy
Henry H. Heng

PNAS March 18, 2014 111 (11) E972; https://doi.org/10.1073/pnas.1323636111
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Reply to Heng: Inborn aneuploidy and chromosomal instability
Anders Valind and David Gisselsson

PNAS March 18, 2014 111 (11) E973; https://doi.org/10.1073/pnas.1323978111
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Does aneuploidy destabilize karyotypes automatically?
Peter H. Duesberg

PNAS March 18, 2014 111 (11) E974; https://doi.org/10.1073/pnas.1401413111
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Reply to Duesberg: Stability of peritriploid and triploid states in neoplastic and nonneoplastic cells
Anders Valind and David Gisselsson

PNAS March 18, 2014 111 (11) E975; https://doi.org/10.1073/pnas.1402008111
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Concerns over the origin of NIH-CQV, a novel virus discovered in Chinese patients with seronegative hepatitis
Samia N. Naccache, John Hackett Jr., Eric L. Delwart, and Charles Y. Chiu

PNAS March 18, 2014 111 (11) E976; https://doi.org/10.1073/pnas.1317064111
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Reply to Naccache et al: Viral sequences of NIH-CQV virus, a contamination of DNA extraction method
Ning Zhi, Gangqing Hu, Susan Wong, Keji Zhao, Qing Mao, and Neal S. Young

PNAS March 18, 2014 111 (11) E977; https://doi.org/10.1073/pnas.1318965111

Science and Culture

How science intersects with culture.

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Protein structure paintings
Front Matter
J. D. Talasek

PNAS March 18, 2014 111 (11) 3899; https://doi.org/10.1073/pnas.1400947111

Profile

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Profile of Andrea Rinaldo
Paul Gabrielsen

PNAS March 18, 2014 111 (11) 3900-3902; https://doi.org/10.1073/pnas.1401995111

Commentaries

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Design and development of effective siRNA delivery vehicles
David Putnam

PNAS March 18, 2014 111 (11) 3903-3904; https://doi.org/10.1073/pnas.1401746111
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Transcriptional pausing to scout ahead for DNA damage
Bennett Van Houten and Caroline Kisker

PNAS March 18, 2014 111 (11) 3905-3906; https://doi.org/10.1073/pnas.1402020111
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Oxygen and animals in Earth history
Andrew H. Knoll and Erik A. Sperling

PNAS March 18, 2014 111 (11) 3907-3908; https://doi.org/10.1073/pnas.1401745111
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Matching and mechanisms in protected area and poverty alleviation research
Arun Agrawal

PNAS March 18, 2014 111 (11) 3909-3910; https://doi.org/10.1073/pnas.1401327111

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS March 18, 2014 111 (11) 3911-3912; https://doi.org/10.1073/pnas.ss11111

Physical Sciences

Applied Physical Sciences
- Open Access
  In vivo X-ray cine-tomography for tracking morphological dynamics
  Tomy dos Santos Rolo, Alexey Ershov, Thomas van de Kamp, and Tilo Baumbach
  
  PNAS March 18, 2014 111 (11) 3921-3926; https://doi.org/10.1073/pnas.1308650111
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  Harvesting renewable energy from Earth’s mid-infrared emissions
  Steven J. Byrnes, Romain Blanchard, and Federico Capasso
  
  PNAS March 18, 2014 111 (11) 3927-3932; https://doi.org/10.1073/pnas.1402036111
- Open Access
  Anisotropic two-dimensional electron gas at SrTiO₃(110)
  Zhiming Wang, Zhicheng Zhong, Xianfeng Hao, Stefan Gerhold, Bernhard Stöger, Michael Schmid, Jaime Sánchez-Barriga, Andrei Varykhalov, Cesare Franchini, Karsten Held, and Ulrike Diebold
  
  PNAS March 18, 2014 111 (11) 3933-3937; https://doi.org/10.1073/pnas.1318304111
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  Nucleation of shear bands in amorphous alloys
  John H. Perepezko, Seth D. Imhoff, Ming-Wei Chen, Jun-Qiang Wang, and Sergio Gonzalez
  
  PNAS March 18, 2014 111 (11) 3938-3942; https://doi.org/10.1073/pnas.1321518111
Chemistry
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  Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus
  Daniel Reker, Tiago Rodrigues, Petra Schneider, and Gisbert Schneider
  
  PNAS March 18, 2014 111 (11) 4067-4072; https://doi.org/10.1073/pnas.1320001111
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  Chemical defenses and resource trade-offs structure sponge communities on Caribbean coral reefs
  From the Cover
  
  Tse-Lynn Loh and Joseph R. Pawlik
  
  PNAS March 18, 2014 111 (11) 4151-4156; https://doi.org/10.1073/pnas.1321626111
Earth, Atmospheric, and Planetary Sciences
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  A controlling role for the air−sea interface in the chemical processing of reactive nitrogen in the coastal marine boundary layer
  Michelle J. Kim, Delphine K. Farmer, and Timothy H. Bertram
  
  PNAS March 18, 2014 111 (11) 3943-3948; https://doi.org/10.1073/pnas.1318694111
- Open Access
  Oxygen requirements of the earliest animals
  From the Cover
  
  Daniel B. Mills, Lewis M. Ward, CarriAyne Jones, Brittany Sweeten, Michael Forth, Alexander H. Treusch, and Donald E. Canfield
  
  PNAS March 18, 2014 111 (11) 4168-4172; https://doi.org/10.1073/pnas.1400547111
Engineering
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  Three-dimensional cell migration does not follow a random walk
  Pei-Hsun Wu, Anjil Giri, Sean X. Sun, and Denis Wirtz
  
  PNAS March 18, 2014 111 (11) 3949-3954; https://doi.org/10.1073/pnas.1318967111
- Open Access
  Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
  From the Cover
  
  Yizhou Dong, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yunlong Zhang, Delai Chen, Roman L. Bogorad, Hao Yin, Yi Chen, Arturo J. Vegas, Christopher A. Alabi, Gaurav Sahay, Karsten T. Olejnik, Weiheng Wang, Avi Schroeder, Abigail K. R. Lytton-Jean, Daniel J. Siegwart, Akin Akinc, Carmen Barnes, Scott A. Barros, Mary Carioto, Kevin Fitzgerald, Julia Hettinger, Varun Kumar, Tatiana I. Novobrantseva, June Qin, William Querbes, Victor Koteliansky, Robert Langer, and Daniel G. Anderson
  
  PNAS March 18, 2014 111 (11) 3955-3960; https://doi.org/10.1073/pnas.1322937111
Environmental Sciences
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  A soil actinobacterium scavenges atmospheric H₂ using two membrane-associated, oxygen-dependent [NiFe] hydrogenases
  Chris Greening, Michael Berney, Kiel Hards, Gregory M. Cook, and Ralf Conrad
  
  PNAS March 18, 2014 111 (11) 4257-4261; https://doi.org/10.1073/pnas.1320586111
Mathematics
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  Holomorphic projections and Ramanujan’s mock theta functions
  Özlem Imamoğlu, Martin Raum, and Olav K. Richter
  
  PNAS March 18, 2014 111 (11) 3961-3967; https://doi.org/10.1073/pnas.1311621111
Physics
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  Quantifying the atomic-level mechanics of single long physisorbed molecular chains
  Shigeki Kawai, Matthias Koch, Enrico Gnecco, Ali Sadeghi, Rémy Pawlak, Thilo Glatzel, Jutta Schwarz, Stefan Goedecker, Stefan Hecht, Alexis Baratoff, Leonhard Grill, and Ernst Meyer
  
  PNAS March 18, 2014 111 (11) 3968-3972; https://doi.org/10.1073/pnas.1319938111
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  Molecular interferometer to decode attosecond electron–nuclear dynamics
  Alicia Palacios, Alberto González-Castrillo, and Fernando Martín
  
  PNAS March 18, 2014 111 (11) 3973-3978; https://doi.org/10.1073/pnas.1316762111
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  Electric double-layer transistor using layered iron selenide Mott insulator TlFe_1.6Se₂
  Takayoshi Katase, Hidenori Hiramatsu, Toshio Kamiya, and Hideo Hosono
  
  PNAS March 18, 2014 111 (11) 3979-3983; https://doi.org/10.1073/pnas.1318045111

Biological Sciences

Agricultural Sciences
- Open Access
  Increasing homogeneity in global food supplies and the implications for food security
  Colin K. Khoury, Anne D. Bjorkman, Hannes Dempewolf, Julian Ramirez-Villegas, Luigi Guarino, Andy Jarvis, Loren H. Rieseberg, and Paul C. Struik
  
  PNAS March 18, 2014 111 (11) 4001-4006; https://doi.org/10.1073/pnas.1313490111
Biochemistry
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  Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner
  Rajas Chodankar, Dai-Ying Wu, Benjamin J. Schiller, Keith R. Yamamoto, and Michael R. Stallcup
  
  PNAS March 18, 2014 111 (11) 4007-4012; https://doi.org/10.1073/pnas.1400522111
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  Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity
  Kent E. S. Matlack, Daniel F. Tardiff, Priyanka Narayan, Shusei Hamamichi, Kim A. Caldwell, Guy A. Caldwell, and Susan Lindquist
  
  PNAS March 18, 2014 111 (11) 4013-4018; https://doi.org/10.1073/pnas.1402228111
- Open Access
  Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
  Christoph Loenarz, Rok Sekirnik, Armin Thalhammer, Wei Ge, Ekaterina Spivakovsky, Mukram M. Mackeen, Michael A. McDonough, Matthew E. Cockman, Benedikt M. Kessler, Peter J. Ratcliffe, Alexander Wolf, and Christopher J. Schofield
  
  PNAS March 18, 2014 111 (11) 4019-4024; https://doi.org/10.1073/pnas.1311750111
- Open Access
  Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
  Maximiliano J. Katz, Julieta M. Acevedo, Christoph Loenarz, Diego Galagovsky, Phebee Liu-Yi, Marcelo Pérez-Pepe, Armin Thalhammer, Rok Sekirnik, Wei Ge, Mariana Melani, María G. Thomas, Sergio Simonetta, Graciela L. Boccaccio, Christopher J. Schofield, Matthew E. Cockman, Peter J. Ratcliffe, and Pablo Wappner
  
  PNAS March 18, 2014 111 (11) 4025-4030; https://doi.org/10.1073/pnas.1314485111
- Open Access
  OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
  Rachelle S. Singleton, Phebee Liu-Yi, Fabio Formenti, Wei Ge, Rok Sekirnik, Roman Fischer, Julie Adam, Patrick J. Pollard, Alexander Wolf, Armin Thalhammer, Christoph Loenarz, Emily Flashman, Atsushi Yamamoto, Mathew L. Coleman, Benedikt M. Kessler, Pablo Wappner, Christopher J. Schofield, Peter J. Ratcliffe, and Matthew E. Cockman
  
  PNAS March 18, 2014 111 (11) 4031-4036; https://doi.org/10.1073/pnas.1314482111
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  Stalled transcription complexes promote DNA repair at a distance
  From the Cover
  
  Nia M. Haines, Young-In T. Kim, Abigail J. Smith, and Nigel J. Savery
  
  PNAS March 18, 2014 111 (11) 4037-4042; https://doi.org/10.1073/pnas.1322350111
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  Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2
  Catherine B. Poor, Seraphine V. Wegner, Haoran Li, Adrienne C. Dlouhy, Jonathan P. Schuermann, Ruslan Sanishvili, James R. Hinshaw, Pamela J. Riggs-Gelasco, Caryn E. Outten, and Chuan He
  
  PNAS March 18, 2014 111 (11) 4043-4048; https://doi.org/10.1073/pnas.1318869111
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  Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog
  Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Sakiyama, Christopher J. Hipolito, Akane Fujioka, Ryo Hirokane, Keiji Ikeguchi, Bunta Watanabe, Jun Hiratake, Yasuhisa Kimura, Hiroaki Suga, Kazumitsu Ueda, and Hiroaki Kato
  
  PNAS March 18, 2014 111 (11) 4049-4054; https://doi.org/10.1073/pnas.1321562111
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  Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain
  Jingling Liao, Chun-Xiang Wu, Christopher Burlak, Sheng Zhang, Heather Sahm, Mu Wang, Zhong-Yin Zhang, Kurt W. Vogel, Mark Federici, Steve M. Riddle, R. Jeremy Nichols, Dali Liu, Mark R. Cookson, Todd A. Stone, and Quyen Q. Hoang
  
  PNAS March 18, 2014 111 (11) 4055-4060; https://doi.org/10.1073/pnas.1323285111
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  Redesign of extensive protein–DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization
  Ryo Takeuchi, Michael Choi, and Barry L. Stoddard
  
  PNAS March 18, 2014 111 (11) 4061-4066; https://doi.org/10.1073/pnas.1321030111
Biophysics and Computational Biology
- Open Access
  In vivo X-ray cine-tomography for tracking morphological dynamics
  Tomy dos Santos Rolo, Alexey Ershov, Thomas van de Kamp, and Tilo Baumbach
  
  PNAS March 18, 2014 111 (11) 3921-3926; https://doi.org/10.1073/pnas.1308650111
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  Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus
  Daniel Reker, Tiago Rodrigues, Petra Schneider, and Gisbert Schneider
  
  PNAS March 18, 2014 111 (11) 4067-4072; https://doi.org/10.1073/pnas.1320001111
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  Single-molecule studies of polymerase dynamics and stoichiometry at the bacteriophage T7 replication machinery
  Hylkje J. Geertsema, Arkadiusz W. Kulczyk, Charles C. Richardson, and Antoine M. van Oijen
  
  PNAS March 18, 2014 111 (11) 4073-4078; https://doi.org/10.1073/pnas.1402010111
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  Graph-based sampling for approximating global helical topologies of RNA
  Namhee Kim, Christian Laing, Shereef Elmetwaly, Segun Jung, Jeremy Curuksu, and Tamar Schlick
  
  PNAS March 18, 2014 111 (11) 4079-4084; https://doi.org/10.1073/pnas.1318893111
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  Strength of a bifurcated H bond
  Esther S. Feldblum and Isaiah T. Arkin
  
  PNAS March 18, 2014 111 (11) 4085-4090; https://doi.org/10.1073/pnas.1319827111
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  Myosin lever arm directs collective motion on cellular actin network
  Rizal F. Hariadi, Mario Cale, and Sivaraj Sivaramakrishnan
  
  PNAS March 18, 2014 111 (11) 4091-4096; https://doi.org/10.1073/pnas.1315923111
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  Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code
  Meng S. Choy, Martina Hieke, Ganesan Senthil Kumar, Greyson R. Lewis, Kristofer R. Gonzalez-DeWhitt, Rene P. Kessler, Benjamin J. Stein, Manuel Hessenberger, Angus C. Nairn, Wolfgang Peti, and Rebecca Page
  
  PNAS March 18, 2014 111 (11) 4097-4102; https://doi.org/10.1073/pnas.1317395111
Cell Biology
- Open Access
  Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis
  Masashi Maekawa, Shimpei Terasaka, Yasuhiro Mochizuki, Katsuhisa Kawai, Yuka Ikeda, Nobukazu Araki, Edward Y. Skolnik, Tomohiko Taguchi, and Hiroyuki Arai
  
  PNAS March 18, 2014 111 (11) E978-E987; https://doi.org/10.1073/pnas.1311029111
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  Three-dimensional cell migration does not follow a random walk
  Pei-Hsun Wu, Anjil Giri, Sean X. Sun, and Denis Wirtz
  
  PNAS March 18, 2014 111 (11) 3949-3954; https://doi.org/10.1073/pnas.1318967111
- Open Access
  Transcriptional divergence and conservation of human and mouse erythropoiesis
  Novalia Pishesha, Prathapan Thiru, Jiahai Shi, Jennifer C. Eng, Vijay G. Sankaran, and Harvey F. Lodish
  
  PNAS March 18, 2014 111 (11) 4103-4108; https://doi.org/10.1073/pnas.1401598111
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  Requirement of MEF2A, C, and D for skeletal muscle regeneration
  Ning Liu, Benjamin R. Nelson, Svetlana Bezprozvannaya, John M. Shelton, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson
  
  PNAS March 18, 2014 111 (11) 4109-4114; https://doi.org/10.1073/pnas.1401732111
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  BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy
  Salwa Sebti, Christine Prébois, Esther Pérez-Gracia, Chantal Bauvy, Fabienne Desmots, Nelly Pirot, Céline Gongora, Anne-Sophie Bach, Andrew V. Hubberstey, Valérie Palissot, Guy Berchem, Patrice Codogno, Laetitia K. Linares, Emmanuelle Liaudet-Coopman, and Sophie Pattingre
  
  PNAS March 18, 2014 111 (11) 4115-4120; https://doi.org/10.1073/pnas.1313618111
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  Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin
  Jonathan D. Winkelman, Colleen G. Bilancia, Mark Peifer, and David R. Kovar
  
  PNAS March 18, 2014 111 (11) 4121-4126; https://doi.org/10.1073/pnas.1322093111
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  Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates
  Roland Thuenauer, Ya-Chu Hsu, Jose Maria Carvajal-Gonzalez, Sylvie Deborde, Jen-Zen Chuang, Winfried Römer, Alois Sonnleitner, Enrique Rodriguez-Boulan, and Ching-Hwa Sung
  
  PNAS March 18, 2014 111 (11) 4127-4132; https://doi.org/10.1073/pnas.1304168111
Developmental Biology
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  BMP signaling is required for the generation of primordial germ cells in an insect
  Seth Donoughe, Taro Nakamura, Ben Ewen-Campen, Delbert A. Green II, Lory Henderson, and Cassandra G. Extavour
  
  PNAS March 18, 2014 111 (11) 4133-4138; https://doi.org/10.1073/pnas.1400525111
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  Fine mapping of genome activation in bovine embryos by RNA sequencing
  Alexander Graf, Stefan Krebs, Valeri Zakhartchenko, Björn Schwalb, Helmut Blum, and Eckhard Wolf
  
  PNAS March 18, 2014 111 (11) 4139-4144; https://doi.org/10.1073/pnas.1321569111
- Open Access
  Seminal vesicle protein SVS2 is required for sperm survival in the uterus
  Natsuko Kawano, Naoya Araki, Kaoru Yoshida, Taku Hibino, Naoko Ohnami, Maako Makino, Seiya Kanai, Hidetoshi Hasuwa, Manabu Yoshida, Kenji Miyado, and Akihiro Umezawa
  
  PNAS March 18, 2014 111 (11) 4145-4150; https://doi.org/10.1073/pnas.1320715111
Ecology
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  Chemical defenses and resource trade-offs structure sponge communities on Caribbean coral reefs
  From the Cover
  
  Tse-Lynn Loh and Joseph R. Pawlik
  
  PNAS March 18, 2014 111 (11) 4151-4156; https://doi.org/10.1073/pnas.1321626111
- Open Access
  Evidence that dimethyl sulfide facilitates a tritrophic mutualism between marine primary producers and top predators
  Matthew S. Savoca and Gabrielle A. Nevitt
  
  PNAS March 18, 2014 111 (11) 4157-4161; https://doi.org/10.1073/pnas.1317120111
- Open Access
  High herbivore density associated with vegetation diversity in interglacial ecosystems
  Christopher J. Sandom, Rasmus Ejrnæs, Morten D. D. Hansen, and Jens-Christian Svenning
  
  PNAS March 18, 2014 111 (11) 4162-4167; https://doi.org/10.1073/pnas.1311014111
Evolution
- Open Access
  Oxygen requirements of the earliest animals
  From the Cover
  
  Daniel B. Mills, Lewis M. Ward, CarriAyne Jones, Brittany Sweeten, Michael Forth, Alexander H. Treusch, and Donald E. Canfield
  
  PNAS March 18, 2014 111 (11) 4168-4172; https://doi.org/10.1073/pnas.1400547111
Genetics
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  Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5
  Taewan Kim, Ri Cui, Young-Jun Jeon, Ji-Hoon Lee, Ju Hee Lee, Hosung Sim, Jong Kook Park, Paolo Fadda, Esmerina Tili, Hiroshi Nakanishi, Man-Il Huh, Sung-Hak Kim, Ju Hwan Cho, Bong Hwan Sung, Yong Peng, Tae Jin Lee, Zhenghua Luo, Hui-Lung Sun, Huijun Wei, Hansjuerg Alder, Jeong Su Oh, Kang Sup Shim, Sang-Bong Ko, and Carlo M. Croce
  
  PNAS March 18, 2014 111 (11) 4173-4178; https://doi.org/10.1073/pnas.1400350111
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  NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation
  Ann-Kathrin Eisfeld, Sebastian Schwind, Kevin W. Hoag, Christopher J. Walker, Sandya Liyanarachchi, Ravi Patel, Xiaomeng Huang, Joseph Markowitz, Wenrui Duan, Gregory A. Otterson, William E. Carson III, Guido Marcucci, Clara D. Bloomfield, and Albert de la Chapelle
  
  PNAS March 18, 2014 111 (11) 4179-4184; https://doi.org/10.1073/pnas.1401727111
- Open Access
  Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast
  Beate Schwer, Danny Asher Bitton, Ana M. Sanchez, Jürg Bähler, and Stewart Shuman
  
  PNAS March 18, 2014 111 (11) 4185-4190; https://doi.org/10.1073/pnas.1321842111
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  G-protein–coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion
  Michael E. Feigin, Bin Xue, Molly C. Hammell, and Senthil K. Muthuswamy
  
  PNAS March 18, 2014 111 (11) 4191-4196; https://doi.org/10.1073/pnas.1320239111
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  Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis
  Vasyl Nesin, Graham Wiley, Maria Kousi, E-Ching Ong, Thomas Lehmann, David J. Nicholl, Mohnish Suri, Nortina Shahrizaila, Nicholas Katsanis, Patrick M. Gaffney, Klaas J. Wierenga, and Leonidas Tsiokas
  
  PNAS March 18, 2014 111 (11) 4197-4202; https://doi.org/10.1073/pnas.1312520111
Immunology
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  Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination
  Astrid Zahn, Anil K. Eranki, Anne-Marie Patenaude, Stephen P. Methot, Heather Fifield, Elena M. Cortizas, Paul Foster, Kohsuke Imai, Anne Durandy, Mani Larijani, Ramiro E. Verdun, and Javier M. Di Noia
  
  PNAS March 18, 2014 111 (11) E988-E997; https://doi.org/10.1073/pnas.1320486111
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  Dendritic cell fate is determined by BCL11A
  Gregory C. Ippolito, Joseph D. Dekker, Yui-Hsi Wang, Bum-Kyu Lee, Arthur L. Shaffer III, Jian Lin, Jason K. Wall, Baeck-Seung Lee, Louis M. Staudt, Yong-Jun Liu, Vishwanath R. Iyer, and Haley O. Tucker
  
  PNAS March 18, 2014 111 (11) E998-E1006; https://doi.org/10.1073/pnas.1319228111
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  Duality of the murine CD8 compartment
  Raphaël Genolet, Julie Leignadier, Magne Østerås, Laurent Farinelli, Brian J. Stevenson, and Immanuel F. Luescher
  
  PNAS March 18, 2014 111 (11) E1007-E1015; https://doi.org/10.1073/pnas.1317847111
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  Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
  Ashraf S. Yousif, Andre Stanlie, Samiran Mondal, Tasuku Honjo, and Nasim A. Begum
  
  PNAS March 18, 2014 111 (11) E1016-E1024; https://doi.org/10.1073/pnas.1402391111
- Open Access
  TGF-β–inducible microRNA-183 silences tumor-associated natural killer cells
  Sarah S. Donatelli, Jun-Min Zhou, Danielle L. Gilvary, Erika A. Eksioglu, Xianghong Chen, W. Douglas Cress, Eric B. Haura, Matthew B. Schabath, Domenico Coppola, Sheng Wei, and Julie Y. Djeu
  
  PNAS March 18, 2014 111 (11) 4203-4208; https://doi.org/10.1073/pnas.1319269111
- Open Access
  C1q as a unique player in angiogenesis with therapeutic implication in wound healing
  Fleur Bossi, Claudio Tripodo, Lucia Rizzi, Roberta Bulla, Chiara Agostinis, Carla Guarnotta, Carine Munaut, Gustavo Baldassarre, Giovanni Papa, Sonia Zorzet, Berhane Ghebrehiwet, Guang Sheng Ling, Marina Botto, and Francesco Tedesco
  
  PNAS March 18, 2014 111 (11) 4209-4214; https://doi.org/10.1073/pnas.1311968111
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  Marginal zone CD169⁺ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance
  Buvana Ravishankar, Rahul Shinde, Haiyun Liu, Kapil Chaudhary, Jillian Bradley, Henrique P. Lemos, Phillip Chandler, Masato Tanaka, David H. Munn, Andrew L. Mellor, and Tracy L. McGaha
  
  PNAS March 18, 2014 111 (11) 4215-4220; https://doi.org/10.1073/pnas.1320924111
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  Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients
  Wen-Chao Wu, Hong-Wei Sun, Hai-Tian Chen, Jing Liang, Xing-Juan Yu, Chong Wu, Zilian Wang, and Limin Zheng
  
  PNAS March 18, 2014 111 (11) 4221-4226; https://doi.org/10.1073/pnas.1320753111
Medical Sciences
- Open Access
  Binding of Pro-Gly-Pro at the active site of leukotriene A₄ hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor
  Alena Stsiapanava, Ulrika Olsson, Min Wan, Thea Kleinschmidt, Dorothea Rutishauser, Roman A. Zubarev, Bengt Samuelsson, Agnes Rinaldo-Matthis, and Jesper Z. Haeggström
  
  PNAS March 18, 2014 111 (11) 4227-4232; https://doi.org/10.1073/pnas.1402136111
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  Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer
  Lindsey M. Kelly, Guillermo Barila, Pengyuan Liu, Viktoria N. Evdokimova, Sumita Trivedi, Federica Panebianco, Manoj Gandhi, Sally E. Carty, Steven P. Hodak, Jianhua Luo, Sanja Dacic, Yan P. Yu, Marina N. Nikiforova, Robert L. Ferris, Daniel L. Altschuler, and Yuri E. Nikiforov
  
  PNAS March 18, 2014 111 (11) 4233-4238; https://doi.org/10.1073/pnas.1321937111
- Open Access
  Tumor suppressor role of phospholipase Cε in Ras-triggered cancers
  Marta Martins, Afshan McCarthy, Rhona Baxendale, Sabrina Guichard, Lorenza Magno, Nicoletta Kessaris, Mona El-Bahrawy, Philipp Yu, and Matilda Katan
  
  PNAS March 18, 2014 111 (11) 4239-4244; https://doi.org/10.1073/pnas.1311500111
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  Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media
  Jillian E. Tengood, Ivan S. Alferiev, Kehan Zhang, Ilia Fishbein, Robert J. Levy, and Michael Chorny
  
  PNAS March 18, 2014 111 (11) 4245-4250; https://doi.org/10.1073/pnas.1324104111
- Open Access
  Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer
  Shan Wang, Rahul K. Kollipara, Nishi Srivastava, Rui Li, Preethi Ravindranathan, Elizabeth Hernandez, Eva Freeman, Caroline G. Humphries, Payal Kapur, Yair Lotan, Ladan Fazli, Martin E. Gleave, Stephen R. Plymate, Ganesh V. Raj, Jer-Tsong Hsieh, and Ralf Kittler
  
  PNAS March 18, 2014 111 (11) 4251-4256; https://doi.org/10.1073/pnas.1322198111
Microbiology
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  Rod-like bacterial shape is maintained by feedback between cell curvature and cytoskeletal localization
  Tristan S. Ursell, Jeffrey Nguyen, Russell D. Monds, Alexandre Colavin, Gabriel Billings, Nikolay Ouzounov, Zemer Gitai, Joshua W. Shaevitz, and Kerwyn Casey Huang
  
  PNAS March 18, 2014 111 (11) E1025-E1034; https://doi.org/10.1073/pnas.1317174111
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  A soil actinobacterium scavenges atmospheric H₂ using two membrane-associated, oxygen-dependent [NiFe] hydrogenases
  Chris Greening, Michael Berney, Kiel Hards, Gregory M. Cook, and Ralf Conrad
  
  PNAS March 18, 2014 111 (11) 4257-4261; https://doi.org/10.1073/pnas.1320586111
- You have access
  microRNAs are biomarkers of oncogenic human papillomavirus infections
  Xiaohong Wang, Hsu-Kun Wang, Yang Li, Markus Hafner, Nilam Sanjib Banerjee, Shuang Tang, Daniel Briskin, Craig Meyers, Louise T. Chow, Xing Xie, Thomas Tuschl, and Zhi-Ming Zheng
  
  PNAS March 18, 2014 111 (11) 4262-4267; https://doi.org/10.1073/pnas.1401430111
- Open Access
  Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota
  Yijun Zhu, Eleanor Jameson, Marialuisa Crosatti, Hendrik Schäfer, Kumar Rajakumar, Timothy D. H. Bugg, and Yin Chen
  
  PNAS March 18, 2014 111 (11) 4268-4273; https://doi.org/10.1073/pnas.1316569111
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  Thirty-thousand-year-old distant relative of giant icosahedral DNA viruses with a pandoravirus morphology
  Matthieu Legendre, Julia Bartoli, Lyubov Shmakova, Sandra Jeudy, Karine Labadie, Annie Adrait, Magali Lescot, Olivier Poirot, Lionel Bertaux, Christophe Bruley, Yohann Couté, Elizaveta Rivkina, Chantal Abergel, and Jean-Michel Claverie
  
  PNAS March 18, 2014 111 (11) 4274-4279; https://doi.org/10.1073/pnas.1320670111
- Open Access
  Combinatorial quorum sensing allows bacteria to resolve their social and physical environment
  Daniel M. Cornforth, Roman Popat, Luke McNally, James Gurney, Thomas C. Scott-Phillips, Alasdair Ivens, Stephen P. Diggle, and Sam P. Brown
  
  PNAS March 18, 2014 111 (11) 4280-4284; https://doi.org/10.1073/pnas.1319175111
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  Structural basis of Flavivirus NS1 assembly and antibody recognition
  Melissa A. Edeling, Michael S. Diamond, and Daved H. Fremont
  
  PNAS March 18, 2014 111 (11) 4285-4290; https://doi.org/10.1073/pnas.1322036111
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  Gene silencing and gene expression in phytopathogenic fungi using a plant virus vector
  Tiziana Mascia, Franco Nigro, Alì Abdallah, Massimo Ferrara, Angelo De Stradis, Roberto Faedda, Peter Palukaitis, and Donato Gallitelli
  
  PNAS March 18, 2014 111 (11) 4291-4296; https://doi.org/10.1073/pnas.1315668111
Neuroscience
- Open Access
  Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice
  Ethan A. Winkler, Jesse D. Sengillo, Abhay P. Sagare, Zhen Zhao, Qingyi Ma, Edward Zuniga, Yaoming Wang, Zhihui Zhong, John S. Sullivan, John H. Griffin, Don W. Cleveland, and Berislav V. Zlokovic
  
  PNAS March 18, 2014 111 (11) E1035-E1042; https://doi.org/10.1073/pnas.1401595111
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  Identification of ocular dominance domains in New World owl monkeys by immediate-early gene expression
  Toru Takahata, Masanobu Miyashita, Shigeru Tanaka, and Jon H. Kaas
  
  PNAS March 18, 2014 111 (11) 4297-4302; https://doi.org/10.1073/pnas.1401951111
- Open Access
  Mossy fiber-evoked subthreshold responses induce timing-dependent plasticity at hippocampal CA3 recurrent synapses
  Federico Brandalise and Urs Gerber
  
  PNAS March 18, 2014 111 (11) 4303-4308; https://doi.org/10.1073/pnas.1317667111
- Open Access
  Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life
  James A. Austin, Gareth S. A. Wright, Seiji Watanabe, J. Günter Grossmann, Svetlana V. Antonyuk, Koji Yamanaka, and S. Samar Hasnain
  
  PNAS March 18, 2014 111 (11) 4309-4314; https://doi.org/10.1073/pnas.1317317111
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  Memory loss in a nonnavigational spatial task after hippocampal inactivation in monkeys
  Patrick A. Forcelli, Guillermo Palchik, Taylor Leath, Jacqueline T. DesJardin, Karen Gale, and Ludise Malkova
  
  PNAS March 18, 2014 111 (11) 4315-4320; https://doi.org/10.1073/pnas.1320562111
- Open Access
  Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors
  Natalia V. Luchkina, Johanna Huupponen, Vernon R. J. Clarke, Sarah K. Coleman, Kari Keinänen, Tomi Taira, and Sari E. Lauri
  
  PNAS March 18, 2014 111 (11) 4321-4326; https://doi.org/10.1073/pnas.1315769111
Physiology
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  Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise
  Milène Catoire, Sheril Alex, Nicolas Paraskevopulos, Frits Mattijssen, Inkie Evers-van Gogh, Gert Schaart, Jacob Jeppesen, Anita Kneppers, Marco Mensink, Peter J. Voshol, Gunilla Olivecrona, Nguan Soon Tan, Matthijs K. C. Hesselink, Jimmy F. Berbée, Patrick C. N. Rensen, Eric Kalkhoven, Patrick Schrauwen, and Sander Kersten
  
  PNAS March 18, 2014 111 (11) E1043-E1052; https://doi.org/10.1073/pnas.1400889111
Plant Biology
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  Endogenous localizome identifies 43 mitotic kinesins in a plant cell
  Tomohiro Miki, Haruko Naito, Momoko Nishina, and Gohta Goshima
  
  PNAS March 18, 2014 111 (11) E1053-E1061; https://doi.org/10.1073/pnas.1311243111
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  Ethylene-orchestrated circuitry coordinates a seedling’s response to soil cover and etiolated growth
  Inaugural Article
  
  Shangwei Zhong, Hui Shi, Chang Xue, Ning Wei, Hongwei Guo, and Xing Wang Deng
  
  PNAS March 18, 2014 111 (11) 3913-3920; https://doi.org/10.1073/pnas.1402491111
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  Actin-dependent plastid movement is required for motive force generation in directional nuclear movement in plants
  Takeshi Higa, Noriyuki Suetsugu, Sam-Geun Kong, and Masamitsu Wada
  
  PNAS March 18, 2014 111 (11) 4327-4331; https://doi.org/10.1073/pnas.1317902111
Sustainability Science
- Open Access
  Quantifying causal mechanisms to determine how protected areas affect poverty through changes in ecosystem services and infrastructure
  From the Cover
  
  Paul J. Ferraro and Merlin M. Hanauer
  
  PNAS March 18, 2014 111 (11) 4332-4337; https://doi.org/10.1073/pnas.1307712111
Systems Biology
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  Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode
  Praveen Agrawal, Tomasz Kurcon, Kanoelani T. Pilobello, John F. Rakus, Sujeethraj Koppolu, Zhongyin Liu, Bianca S. Batista, William S. Eng, Ku-Lung Hsu, Yaxuan Liang, and Lara K. Mahal
  
  PNAS March 18, 2014 111 (11) 4338-4343; https://doi.org/10.1073/pnas.1321524111

Corrections

You have access
Correction for Xu et al., Hybrid DNA virus in Chinese patients with seronegative hepatitis discovered by deep sequencing
PNAS March 18, 2014 111 (11) 4344-4345; https://doi.org/10.1073/pnas.1402288111
You have access
Correction for Mitchell et al., mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases
PNAS March 18, 2014 111 (11) 4346; https://doi.org/10.1073/pnas.1401790111

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