Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo

    Mark Juhas, George C. Engelmayr Jr., Andrew N. Fontanella, Gregory M. Palmer, and Nenad Bursac

    PNAS April 15, 2014 111 (15) 5508-5513; first published March 31, 2014. https://doi.org/10.1073/pnas.1402723111

• Biochemistry

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    Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes

    Peyton Shieh, M. Sloan Siegrist, Andrew J. Cullen, and Carolyn R. Bertozzi

    PNAS April 15, 2014 111 (15) 5456-5461; first published March 31, 2014. https://doi.org/10.1073/pnas.1322727111
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    The docking protein FRS2α is a critical regulator of VEGF receptors signaling

    Pei-Yu Chen, Lingfeng Qin, Zhen W. Zhuang, George Tellides, Irit Lax, Joseph Schlessinger, and Michael Simons

    PNAS April 15, 2014 111 (15) 5514-5519; first published April 2, 2014. https://doi.org/10.1073/pnas.1404545111
  • Open Access

    Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

    Vincent S. Tagliabracci, James L. Engel, Sandra E. Wiley, Junyu Xiao, David J. Gonzalez, Hitesh Nidumanda Appaiah, Antonius Koller, Victor Nizet, Kenneth E. White, and Jack E. Dixon

    PNAS April 15, 2014 111 (15) 5520-5525; first published March 26, 2014. https://doi.org/10.1073/pnas.1402218111
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    Chronology in lesion tolerance gives priority to genetic variability

    Karel Naiman, Gaëlle Philippin, Robert P. Fuchs, and Vincent Pagès

    PNAS April 15, 2014 111 (15) 5526-5531; first published March 28, 2014. https://doi.org/10.1073/pnas.1321008111

• Biophysics and Computational Biology

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    Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4

    Gregory T. Tietjen, Zhiliang Gong, Chiu-Hao Chen, Ernesto Vargas, James E. Crooks, Kathleen D. Cao, Charles T. R. Heffern, J. Michael Henderson, Mati Meron, Binhua Lin, Benoît Roux, Mark L. Schlossman, Theodore L. Steck, Ka Yee C. Lee, and Erin J. Adams

    PNAS April 15, 2014 111 (15) E1463-E1472; first published March 31, 2014. https://doi.org/10.1073/pnas.1320174111
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    From a structural average to the conformational ensemble of a DNA bulge

    Xuesong Shi, Kyle A. Beauchamp, Pehr B. Harbury, and Daniel Herschlag

    PNAS April 15, 2014 111 (15) E1473-E1480; first published March 31, 2014. https://doi.org/10.1073/pnas.1317032111
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    Understanding the mechanism of proteasome 20S core particle gating

    Michael P. Latham, Ashok Sekhar, and Lewis E. Kay

    PNAS April 15, 2014 111 (15) 5532-5537; first published March 31, 2014. https://doi.org/10.1073/pnas.1322079111
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    A frameshifting stimulatory stem loop destabilizes the hybrid state and impedes ribosomal translocation

    Hee-Kyung Kim, Fei Liu, Jingyi Fei, Carlos Bustamante, Ruben L. Gonzalez Jr., and Ignacio Tinoco Jr.

    PNAS April 15, 2014 111 (15) 5538-5543; first published March 31, 2014. https://doi.org/10.1073/pnas.1403457111
  • Open Access

    Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome

    Pia Unverdorben, Florian Beck, Paweł Śledź, Andreas Schweitzer, Günter Pfeifer, Jürgen M. Plitzko, Wolfgang Baumeister, and Friedrich Förster

    PNAS April 15, 2014 111 (15) 5544-5549; first published March 24, 2014. https://doi.org/10.1073/pnas.1403409111
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    Crosstalk and the evolution of specificity in two-component signaling

    Michael A. Rowland and Eric J. Deeds

    PNAS April 15, 2014 111 (15) 5550-5555; first published March 31, 2014. https://doi.org/10.1073/pnas.1317178111
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    Solid-state electron transport via cytochrome c depends on electronic coupling to electrodes and across the protein

    Nadav Amdursky, Doron Ferber, Carlo Augusto Bortolotti, Dmitry A. Dolgikh, Rita V. Chertkova, Israel Pecht, Mordechai Sheves, and David Cahen

    PNAS April 15, 2014 111 (15) 5556-5561; first published March 31, 2014. https://doi.org/10.1073/pnas.1319351111
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    Dimerization of mammalian kinesin-3 motors results in superprocessive motion

    Virupakshi Soppina, Stephen R. Norris, Aslan S. Dizaji, Matt Kortus, Sarah Veatch, Michelle Peckham, and Kristen J. Verhey

    PNAS April 15, 2014 111 (15) 5562-5567; first published April 2, 2014. https://doi.org/10.1073/pnas.1400759111
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    Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin

    Lorenz Rognoni, Tobias Möst, Gabriel Žoldák, and Matthias Rief

    PNAS April 15, 2014 111 (15) 5568-5573; first published April 2, 2014. https://doi.org/10.1073/pnas.1319448111

• Cell Biology

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    Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition

    Anan Yu, Yoko Shibata, Bijal Shah, Barbara Calamini, Donald C. Lo, and Richard I. Morimoto

    PNAS April 15, 2014 111 (15) E1481-E1490; first published April 1, 2014. https://doi.org/10.1073/pnas.1321811111
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    Sumoylation differentially regulates Sp1 to control cell differentiation

    Lili Gong, Wei-Ke Ji, Xiao-Hui Hu, Wen-Feng Hu, Xiang-Cheng Tang, Zhao-Xia Huang, Ling Li, Mugen Liu, Shi-Hua Xiang, Erxi Wu, Zachary Woodward, Yi-Zhi Liu, Quan Dong Nguyen, and David Wan-Cheng Li

    PNAS April 15, 2014 111 (15) 5574-5579; first published March 27, 2014. https://doi.org/10.1073/pnas.1315034111
  • Open Access

    Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation

    James E. Dixon, Disheet A. Shah, Catherine Rogers, Stephen Hall, Nicola Weston, Christopher D. J. Parmenter, Donal McNally, Chris Denning, and Kevin M. Shakesheff

    PNAS April 15, 2014 111 (15) 5580-5585; first published March 27, 2014. https://doi.org/10.1073/pnas.1319685111

• Developmental Biology

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    Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

    Hisham Bazzi and Kathryn V. Anderson

    PNAS April 15, 2014 111 (15) E1491-E1500; first published March 31, 2014. https://doi.org/10.1073/pnas.1400568111
  • Open Access

    Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

    Giacomo Donati, Valentina Proserpio, Beate Maria Lichtenberger, Ken Natsuga, Rodney Sinclair, Hironobu Fujiwara, and Fiona M. Watt

    PNAS April 15, 2014 111 (15) E1501-E1509; first published March 31, 2014. https://doi.org/10.1073/pnas.1312880111
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    Spatial constraints control cell proliferation in tissues

    Sebastian J. Streichan, Christian R. Hoerner, Tatjana Schneidt, Daniela Holzer, and Lars Hufnagel

    PNAS April 15, 2014 111 (15) 5586-5591; first published March 31, 2014. https://doi.org/10.1073/pnas.1323016111
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    O-GlcNAc reports ambient temperature and confers heat resistance on ectotherm development

    Pablo T. Radermacher, Faina Myachina, Fritz Bosshardt, Rahul Pandey, Daniel Mariappa, H.-Arno J. Müller, and Christian F. Lehner

    PNAS April 15, 2014 111 (15) 5592-5597; first published March 31, 2014. https://doi.org/10.1073/pnas.1322396111

• Ecology

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    Fine-scale ecological and economic assessment of climate change on olive in the Mediterranean Basin reveals winners and losers

    Luigi Ponti, Andrew Paul Gutierrez, Paolo Michele Ruti, and Alessandro Dell’Aquila

    PNAS April 15, 2014 111 (15) 5598-5603; first published March 24, 2014. https://doi.org/10.1073/pnas.1314437111
  • Open Access

    Amazonian functional diversity from forest canopy chemical assembly

    • From the Cover

    Gregory P. Asner, Roberta E. Martin, Raul Tupayachi, Christopher B. Anderson, Felipe Sinca, Loreli Carranza-Jiménez, and Paola Martinez

    PNAS April 15, 2014 111 (15) 5604-5609; first published March 3, 2014. https://doi.org/10.1073/pnas.1401181111

    See companion article:

    • Functional megadiversity

      - Apr 22, 2014
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    Thermal-safety margins and the necessity of thermoregulatory behavior across latitude and elevation

    • From the Cover

    Jennifer M. Sunday, Amanda E. Bates, Michael R. Kearney, Robert K. Colwell, Nicholas K. Dulvy, John T. Longino, and Raymond B. Huey

    PNAS April 15, 2014 111 (15) 5610-5615; first published March 10, 2014. https://doi.org/10.1073/pnas.1316145111

    See companion article:

    • Biologically grounded predictions of species resistance and resilience to climate change

      - Apr 15, 2014
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    Trait-mediated assembly processes predict successional changes in community diversity of tropical forests

    Jesse R. Lasky, María Uriarte, Vanessa K. Boukili, and Robin L. Chazdon

    PNAS April 15, 2014 111 (15) 5616-5621; first published March 31, 2014. https://doi.org/10.1073/pnas.1319342111
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    Competition–dispersal tradeoff ecologically differentiates recently speciated marine bacterioplankton populations

    Yutaka Yawata, Otto X. Cordero, Filippo Menolascina, Jan-Hendrik Hehemann, Martin F. Polz, and Roman Stocker

    PNAS April 15, 2014 111 (15) 5622-5627; first published April 1, 2014. https://doi.org/10.1073/pnas.1318943111
  • Open Access

    Deoxygenation of the Baltic Sea during the last century

    Jacob Carstensen, Jesper H. Andersen, Bo G. Gustafsson, and Daniel J. Conley

    PNAS April 15, 2014 111 (15) 5628-5633; first published March 31, 2014. https://doi.org/10.1073/pnas.1323156111

• Environmental Sciences

  • Open Access

    Deepwater Horizon crude oil impacts the developing hearts of large predatory pelagic fish

    • From the Cover

    John P. Incardona, Luke D. Gardner, Tiffany L. Linbo, Tanya L. Brown, Andrew J. Esbaugh, Edward M. Mager, John D. Stieglitz, Barbara L. French, Jana S. Labenia, Cathy A. Laetz, Mark Tagal, Catherine A. Sloan, Abigail Elizur, Daniel D. Benetti, Martin Grosell, Barbara A. Block, and Nathaniel L. Scholz

    PNAS April 15, 2014 111 (15) E1510-E1518; first published March 24, 2014. https://doi.org/10.1073/pnas.1320950111

• Evolution

  • Open Access

    Methanogenic burst in the end-Permian carbon cycle

    Daniel H. Rothman, Gregory P. Fournier, Katherine L. French, Eric J. Alm, Edward A. Boyle, Changqun Cao, and Roger E. Summons

    PNAS April 15, 2014 111 (15) 5462-5467; first published March 31, 2014. https://doi.org/10.1073/pnas.1318106111
  • Open Access

    SQUID–SIMS is a useful approach to uncover primary signals in the Archean sulfur cycle

    Woodward W. Fischer, David A. Fike, Jena E. Johnson, Timothy D. Raub, Yunbin Guan, Joseph L. Kirschvink, and John M. Eiler

    PNAS April 15, 2014 111 (15) 5468-5473; first published April 1, 2014. https://doi.org/10.1073/pnas.1322577111
  • Open Access

    Geothermal activity helps life survive glacial cycles

    • From the Cover

    Ceridwen I. Fraser, Aleks Terauds, John Smellie, Peter Convey, and Steven L. Chown

    PNAS April 15, 2014 111 (15) 5634-5639; first published March 10, 2014. https://doi.org/10.1073/pnas.1321437111

    See companion article:

    • Diverse cryptic refuges for life during glaciation

      - Apr 15, 2014

• Genetics

  • Open Access

    Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis

    Sergey O. Sulima, Stephanie Patchett, Vivek M. Advani, Kim De Keersmaecker, Arlen W. Johnson, and Jonathan D. Dinman

    PNAS April 15, 2014 111 (15) 5640-5645; first published March 31, 2014. https://doi.org/10.1073/pnas.1400247111

• Immunology

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    Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I–mediated antiviral innate immunity

    Kanako Kuniyoshi, Osamu Takeuchi, Surya Pandey, Takashi Satoh, Hidenori Iwasaki, Shizuo Akira, and Taro Kawai

    PNAS April 15, 2014 111 (15) 5646-5651; first published March 27, 2014. https://doi.org/10.1073/pnas.1401674111
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    Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal-center interactions

    Lauren E. Higdon, Katherine A. Deets, Travis J. Friesen, Kai-Yin Sze, and Pamela J. Fink

    PNAS April 15, 2014 111 (15) 5652-5657; first published March 31, 2014. https://doi.org/10.1073/pnas.1321803111
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    Enforcement of γδ-lineage commitment by the pre–T-cell receptor in precursors with weak γδ-TCR signals

    Payam Zarin, Gladys W. Wong, Mahmood Mohtashami, David L. Wiest, and Juan Carlos Zúñiga-Pflücker

    PNAS April 15, 2014 111 (15) 5658-5663; first published March 31, 2014. https://doi.org/10.1073/pnas.1312872111
  • Open Access

    T helper 17 cells play a critical pathogenic role in lung cancer

    Seon Hee Chang, Seyedeh Golsar Mirabolfathinejad, Harshadadevi Katta, Amber M. Cumpian, Lei Gong, Mauricio S. Caetano, Seyed Javad Moghaddam, and Chen Dong

    PNAS April 15, 2014 111 (15) 5664-5669; first published March 31, 2014. https://doi.org/10.1073/pnas.1319051111
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    Cryptic MHC class I-binding peptides are revealed by aminoglycoside-induced stop codon read-through into the 3′ UTR

    Elliot Goodenough, Tara M. Robinson, Matthew B. Zook, Kevin M. Flanigan, John F. Atkins, Michael T. Howard, and Laurence C. Eisenlohr

    PNAS April 15, 2014 111 (15) 5670-5675; first published March 31, 2014. https://doi.org/10.1073/pnas.1402670111

• Medical Sciences

  • Open Access

    Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype

    • From the Cover

    Jan M. McAllister, Bhavi Modi, Bruce A. Miller, Jessica Biegler, Richard Bruggeman, Richard S. Legro, and Jerome F. Strauss III

    PNAS April 15, 2014 111 (15) E1519-E1527; first published March 31, 2014. https://doi.org/10.1073/pnas.1400574111
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    IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4⁺ T cells for heterosubtypic protection

    Sophie A. Valkenburg, Olive T. W. Li, Polly W. Y. Mak, Chris K. P. Mok, John M. Nicholls, Yi Guan, Thomas A. Waldmann, J. S. Malik Peiris, Liyanage P. Perera, and Leo L. M. Poon

    PNAS April 15, 2014 111 (15) 5676-5681; first published March 31, 2014. https://doi.org/10.1073/pnas.1403684111
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    Bcl2L13 is a ceramide synthase inhibitor in glioblastoma

    Samuel A. Jensen, Andrea E. Calvert, Giora Volpert, Fotini M. Kouri, Lisa A. Hurley, Janina P. Luciano, Yongfei Wu, Alexandra Chalastanis, Anthony H. Futerman, and Alexander H. Stegh

    PNAS April 15, 2014 111 (15) 5682-5687; first published March 31, 2014. https://doi.org/10.1073/pnas.1316700111

• Microbiology

  • Open Access

    Heat shock protein 90 controls HIV-1 reactivation from latency

    Ian Anderson, Jun Siong Low, Stuart Weston, Michael Weinberger, Alexander Zhyvoloup, Aksana A. Labokha, Gianmarco Corazza, Russell A. Kitson, Christopher J. Moody, Alessandro Marcello, and Ariberto Fassati

    PNAS April 15, 2014 111 (15) E1528-E1537; first published March 31, 2014. https://doi.org/10.1073/pnas.1320178111
  • Open Access

    Uncoupling reproduction from metabolism extends chronological lifespan in yeast

    Saisubramanian Nagarajan, Arthur L. Kruckeberg, Karen H. Schmidt, Evgueny Kroll, Morgan Hamilton, Kate McInnerney, Ryan Summers, Timothy Taylor, and Frank Rosenzweig

    PNAS April 15, 2014 111 (15) E1538-E1547; first published March 31, 2014. https://doi.org/10.1073/pnas.1323918111
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    Proteomic analysis of Vibrio cholerae outer membrane vesicles

    Emrah Altindis, Yang Fu, and John J. Mekalanos

    PNAS April 15, 2014 111 (15) E1548-E1556; first published March 31, 2014. https://doi.org/10.1073/pnas.1403683111
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    Angucyclines as signals modulate the behaviors of Streptomyces coelicolor

    Weishan Wang, Junjie Ji, Xiao Li, Juan Wang, Shanshan Li, Guohui Pan, Keqiang Fan, and Keqian Yang

    PNAS April 15, 2014 111 (15) 5688-5693; first published March 28, 2014. https://doi.org/10.1073/pnas.1324253111
  • Open Access

    Global dissemination of a multidrug resistant Escherichia coli clone

    Nicola K. Petty, Nouri L. Ben Zakour, Mitchell Stanton-Cook, Elizabeth Skippington, Makrina Totsika, Brian M. Forde, Minh-Duy Phan, Danilo Gomes Moriel, Kate M. Peters, Mark Davies, Benjamin A. Rogers, Gordon Dougan, Jesús Rodriguez-Baño, Alvaro Pascual, Johann D. D. Pitout, Mathew Upton, David L. Paterson, Timothy R. Walsh, Mark A. Schembri, and Scott A. Beatson

    PNAS April 15, 2014 111 (15) 5694-5699; first published March 31, 2014. https://doi.org/10.1073/pnas.1322678111

• Neuroscience

  • Open Access

    Cellular mechanisms for integral feedback in visually guided behavior

    Bettina Schnell, Peter T. Weir, Eatai Roth, Adrienne L. Fairhall, and Michael H. Dickinson

    PNAS April 15, 2014 111 (15) 5700-5705; first published March 31, 2014. https://doi.org/10.1073/pnas.1400698111
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    Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A

    Kavita P. Bhat, Sen Yan, Chuan-En Wang, Shihua Li, and Xiao-Jiang Li

    PNAS April 15, 2014 111 (15) 5706-5711; first published March 31, 2014. https://doi.org/10.1073/pnas.1402215111
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    Functional evolution of Erg potassium channel gating reveals an ancient origin for I_Kr

    Alexandra S. Martinson, Damian B. van Rossum, Fortunay H. Diatta, Michael J. Layden, Sarah A. Rhodes, Mark Q. Martindale, and Timothy Jegla

    PNAS April 15, 2014 111 (15) 5712-5717; first published March 31, 2014. https://doi.org/10.1073/pnas.1321716111
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    Neural representations of ethologically relevant hand/mouth synergies in the human precentral gyrus

    Michel Desmurget, Nathalie Richard, Sylvain Harquel, Pierre Baraduc, Alexandru Szathmari, Carmine Mottolese, and Angela Sirigu

    PNAS April 15, 2014 111 (15) 5718-5722; first published March 31, 2014. https://doi.org/10.1073/pnas.1321909111

• Physiology

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    Compound facial expressions of emotion

    Shichuan Du, Yong Tao, and Aleix M. Martinez

    PNAS April 15, 2014 111 (15) E1454-E1462; first published March 31, 2014. https://doi.org/10.1073/pnas.1322355111
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    Microtubule binding distinguishes dystrophin from utrophin

    Joseph J. Belanto, Tara L. Mader, Michael D. Eckhoff, Dana M. Strandjord, Glen B. Banks, Melissa K. Gardner, Dawn A. Lowe, and James M. Ervasti

    PNAS April 15, 2014 111 (15) 5723-5728; first published March 31, 2014. https://doi.org/10.1073/pnas.1323842111
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    Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster

    Arpan C. Ghosh and Michael B. O’Connor

    PNAS April 15, 2014 111 (15) 5729-5734; first published March 31, 2014. https://doi.org/10.1073/pnas.1319116111
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    Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice

    Huizhen Wang, Melissa Larson, Albina Jablonka-Shariff, Christopher A. Pearl, William L. Miller, P. Michael Conn, Irving Boime, and T. Rajendra Kumar

    PNAS April 15, 2014 111 (15) 5735-5740; first published March 31, 2014. https://doi.org/10.1073/pnas.1321404111

• Plant Biology

  • Open Access

    Abscisic acid sensor RCAR7/PYL13, specific regulator of protein phosphatase coreceptors

    Stefan Fuchs, Stefanie V. Tischer, Christian Wunschel, Alexander Christmann, and Erwin Grill

    PNAS April 15, 2014 111 (15) 5741-5746; first published April 1, 2014. https://doi.org/10.1073/pnas.1322085111

• Systems Biology

  • Open Access

    Identifying regulatory mechanisms underlying tumorigenesis using locus expression signature analysis

    Eunjee Lee, Jeroen de Ridder, Jaap Kool, Lodewyk F. A. Wessels, and Harmen J. Bussemaker

    PNAS April 15, 2014 111 (15) 5747-5752; first published April 2, 2014. https://doi.org/10.1073/pnas.1309293111