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Research Article

A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors

Xin-Cheng Qin, Mang Shi, Jun-Hua Tian, Xian-Dan Lin, Dong-Ya Gao, Jin-Rong He, Jian-Bo Wang, Ci-Xiu Li, Yan-Jun Kang, Bin Yu, Dun-Jin Zhou, Jianguo Xu, Alexander Plyusnin, Edward C. Holmes, and Yong-Zhen Zhang
PNAS May 6, 2014 111 (18) 6744-6749; first published April 21, 2014; https://doi.org/10.1073/pnas.1324194111
Xin-Cheng Qin
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
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Mang Shi
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
bMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia;
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Jun-Hua Tian
cWuhan Center for Disease Control and Prevention, Wuhan 430015, China;
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Xian-Dan Lin
dWenzhou Center for Disease Control and Prevention, Wenzhou 325001, China; and
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Dong-Ya Gao
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
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Jin-Rong He
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
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Jian-Bo Wang
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
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Ci-Xiu Li
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
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Yan-Jun Kang
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
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Bin Yu
cWuhan Center for Disease Control and Prevention, Wuhan 430015, China;
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Dun-Jin Zhou
cWuhan Center for Disease Control and Prevention, Wuhan 430015, China;
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Jianguo Xu
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
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Alexander Plyusnin
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
eDepartment of Virology, Haartman Institute, University of Helsinki, 00014, Helsinki, Finland
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Edward C. Holmes
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
bMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia;
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Yong-Zhen Zhang
aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
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  • For correspondence: zhangyongzhen@icdc.cn
  1. Edited by Peter Palese, Icahn School of Medicine at Mount Sinai, New York, NY, and approved March 27, 2014 (received for review December 30, 2013)

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Article Information

vol. 111 no. 18 6744-6749
DOI: 
https://doi.org/10.1073/pnas.1324194111
PubMed: 
24753611

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue May 6, 2014.
  • Published first April 21, 2014.


Author Information

  1. Xin-Cheng Qina,1,
  2. Mang Shia,b,1,
  3. Jun-Hua Tianc,1,
  4. Xian-Dan Lind,1,
  5. Dong-Ya Gaoa,
  6. Jin-Rong Hea,
  7. Jian-Bo Wanga,
  8. Ci-Xiu Lia,
  9. Yan-Jun Kanga,
  10. Bin Yuc,
  11. Dun-Jin Zhouc,
  12. Jianguo Xua,
  13. Alexander Plyusnina,e,
  14. Edward C. Holmesa,b, and
  15. Yong-Zhen Zhanga,2
  1. aState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100206, China;
  2. bMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia;
  3. cWuhan Center for Disease Control and Prevention, Wuhan 430015, China;
  4. dWenzhou Center for Disease Control and Prevention, Wenzhou 325001, China; and
  5. eDepartment of Virology, Haartman Institute, University of Helsinki, 00014, Helsinki, Finland
  1. Edited by Peter Palese, Icahn School of Medicine at Mount Sinai, New York, NY, and approved March 27, 2014 (received for review December 30, 2013)

Footnotes

  • ↵1X.-C.Q., M.S., J.-H.T., and X.-D.L. contributed equally to this work.

  • ↵2To whom correspondence should be addressed. E-mail: zhangyongzhen{at}icdc.cn.
  • Author contributions: X.-C.Q., M.S., and Y.-Z.Z. designed research; X.-C.Q., M.S., J.-H.T., X.-D.L., D.-Y.G., J.-R.H., C.-X.L., and Y.-J.K. performed research; J.-H.T., X.-D.L., J.-B.W., B.Y., D.-J.Z., and J.X. contributed new reagents/analytic tools; X.-C.Q., M.S., J.X., A.P., E.C.H., and Y.-Z.Z. analyzed data; and M.S., A.P., E.C.H., and Y.-Z.Z. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • Data deposition: The sequences reported in this paper have been deposited in the GenBank database (accession nos. KJ001547–KJ001634).

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1324194111/-/DCSupplemental.

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Article usage

Article usage: April 2014 to January 2021

AbstractFullPdf
Apr 201417633162
May 20143011136233
Jun 201457380125
Jul 20143024754
Aug 20141951015
Sep 20142415325
Oct 20142243024
Nov 20141162322
Dec 20141723124
Total 20146597413684
Jan 20151111719
Feb 201587187
Mar 2015833617
Apr 2015891219
May 2015783614
Jun 2015481118
Jul 2015532315
Aug 2015481124
Sep 201544138
Oct 2015632624
Nov 2015391712
Dec 2015601821
Total 2015803238198
Jan 2016651418
Feb 2016441728
Mar 2016681736
Apr 2016521625
May 2016421322
Jun 2016372318
Jul 201646920
Aug 20161372126
Sep 2016882735
Oct 2016932427
Nov 2016953434
Dec 2016903722
Total 2016857252311
Jan 2017822127
Feb 2017692919
Mar 2017703236
Apr 2017531713
May 2017521924
Jun 2017241924
Jul 2017272119
Aug 2017461424
Sep 2017261917
Oct 2017332417
Nov 2017572413
Dec 20174579
Total 2017584246242
Jan 2018451822
Feb 2018536723
Mar 2018516825
Apr 20188410524
May 2018525513
Jun 2018465718
Jul 2018545713
Aug 2018667022
Sep 2018729033
Oct 2018147224
Nov 2018820029
Dec 201887116
Total 2018553930262
Jan 2019216816
Feb 2019196824
Mar 2019236020
Apr 2019198424
May 20191411541
Jun 20191933249
Jul 201987932
Aug 2019135620
Sep 2019138031
Oct 20191413425
Nov 20192910813
Dec 2019154913
Total 20192071233308
Jan 2020218020
Feb 2020189431
Mar 202076732
Apr 2020159613
May 2020811146
Jun 20201514926
Jul 202025916
Aug 202075512
Sep 2020114922
Oct 2020136834
Nov 20202711030
Dec 20202116137
Total 20201651099319
Jan 2021126529
Total 2021126529
Total977844762353
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Segmented relative of flavivirus
Xin-Cheng Qin, Mang Shi, Jun-Hua Tian, Xian-Dan Lin, Dong-Ya Gao, Jin-Rong He, Jian-Bo Wang, Ci-Xiu Li, Yan-Jun Kang, Bin Yu, Dun-Jin Zhou, Jianguo Xu, Alexander Plyusnin, Edward C. Holmes, Yong-Zhen Zhang
Proceedings of the National Academy of Sciences May 2014, 111 (18) 6744-6749; DOI: 10.1073/pnas.1324194111

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Segmented relative of flavivirus
Xin-Cheng Qin, Mang Shi, Jun-Hua Tian, Xian-Dan Lin, Dong-Ya Gao, Jin-Rong He, Jian-Bo Wang, Ci-Xiu Li, Yan-Jun Kang, Bin Yu, Dun-Jin Zhou, Jianguo Xu, Alexander Plyusnin, Edward C. Holmes, Yong-Zhen Zhang
Proceedings of the National Academy of Sciences May 2014, 111 (18) 6744-6749; DOI: 10.1073/pnas.1324194111
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