Table of Contents

Biological Sciences

• Anthropology

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    Third-party punishment increases cooperation in children through (misaligned) expectations and conditional cooperation

    Philipp Lergetporer, Silvia Angerer, Daniela Glätzle-Rützler, and Matthias Sutter

    PNAS May 13, 2014 111 (19) 6916-6921; first published April 28, 2014. https://doi.org/10.1073/pnas.1320451111

• Applied Biological Sciences

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    Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation

    Sarindr Bhumiratana, Ryan E. Eton, Sevan R. Oungoulian, Leo Q. Wan, Gerard A. Ateshian, and Gordana Vunjak-Novakovic

    PNAS May 13, 2014 111 (19) 6940-6945; first published April 28, 2014. https://doi.org/10.1073/pnas.1324050111
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    Collagen-binding protein, Aegyptin, regulates probing time and blood feeding success in the dengue vector mosquito, Aedes aegypti

    Andrezza Campos Chagas, José Luis Ramirez, Nijole Jasinskiene, Anthony A. James, José M. C. Ribeiro, Osvaldo Marinotti, and Eric Calvo

    PNAS May 13, 2014 111 (19) 6946-6951; first published April 28, 2014. https://doi.org/10.1073/pnas.1404179111
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    Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF₁₆₄

    Veronica Sacchi, Rainer Mittermayr, Joachim Hartinger, Mikaël M. Martino, Kristen M. Lorentz, Susanne Wolbank, Anna Hofmann, Remo A. Largo, Jeffrey S. Marschall, Elena Groppa, Roberto Gianni-Barrera, Martin Ehrbar, Jeffrey A. Hubbell, Heinz Redl, and Andrea Banfi

    PNAS May 13, 2014 111 (19) 6952-6957; first published April 28, 2014. https://doi.org/10.1073/pnas.1404605111

• Biochemistry

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    Heterodimeric coiled-coil interactions of human GABA_B receptor

    Svetlana Burmakina, Yong Geng, Yan Chen, and Qing R. Fan

    PNAS May 13, 2014 111 (19) 6958-6963; first published April 28, 2014. https://doi.org/10.1073/pnas.1400081111
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    Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase

    Irina Pader, Rajib Sengupta, Marcus Cebula, Jianqiang Xu, Jon O. Lundberg, Arne Holmgren, Katarina Johansson, and Elias S. J. Arnér

    PNAS May 13, 2014 111 (19) 6964-6969; first published April 28, 2014. https://doi.org/10.1073/pnas.1317320111
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    TRIM65 regulates microRNA activity by ubiquitination of TNRC6

    Shitao Li, Lingyan Wang, Bishi Fu, Michael A. Berman, Alos Diallo, and Martin E. Dorf

    PNAS May 13, 2014 111 (19) 6970-6975; first published April 28, 2014. https://doi.org/10.1073/pnas.1322545111

• Biophysics and Computational Biology

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    A model for the generation and transmission of variations in evolution

    Olivier Rivoire and Stanislas Leibler

    PNAS May 13, 2014 111 (19) E1940-E1949; first published April 24, 2014. https://doi.org/10.1073/pnas.1323901111
  • Open Access

    Moving gating charges through the gating pore in a Kv channel voltage sensor

    Jérôme J. Lacroix, H. Clark Hyde, Fabiana V. Campos, and Francisco Bezanilla

    PNAS May 13, 2014 111 (19) E1950-E1959; first published April 29, 2014. https://doi.org/10.1073/pnas.1406161111
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    Gait synchronization in Caenorhabditis elegans

    Jinzhou Yuan, David M. Raizen, and Haim H. Bau

    PNAS May 13, 2014 111 (19) 6865-6870; first published April 28, 2014. https://doi.org/10.1073/pnas.1401828111
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    Redox active motifs in selenoproteins

    Fei Li, Patricia B. Lutz, Yuliya Pepelyayeva, Elias S. J. Arnér, Craig A. Bayse, and Sharon Rozovsky

    PNAS May 13, 2014 111 (19) 6976-6981; first published April 25, 2014. https://doi.org/10.1073/pnas.1319022111
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    Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation

    Mark R. Ambroso, Balachandra G. Hegde, and Ralf Langen

    PNAS May 13, 2014 111 (19) 6982-6987; first published April 28, 2014. https://doi.org/10.1073/pnas.1402233111
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    Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I

    Ville R. I. Kaila, Mårten Wikström, and Gerhard Hummer

    PNAS May 13, 2014 111 (19) 6988-6993; first published April 28, 2014. https://doi.org/10.1073/pnas.1319156111
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    Phenotypic switching in gene regulatory networks

    Philipp Thomas, Nikola Popović, and Ramon Grima

    PNAS May 13, 2014 111 (19) 6994-6999; first published April 29, 2014. https://doi.org/10.1073/pnas.1400049111
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    CK2 activates kinesin via induction of a conformational change

    Michelle K. Mattson-Hoss, Yamato Niitani, Elizabeth A. Gordon, Yonggun Jun, Lee Bardwell, Michio Tomishige, and Steven P. Gross

    PNAS May 13, 2014 111 (19) 7000-7005; first published April 29, 2014. https://doi.org/10.1073/pnas.1321419111

• Cell Biology

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    CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120_IIIB binding to the cell surface

    Laura Martínez-Muñoz, Rubén Barroso, Sunniva Y. Dyrhaug, Gemma Navarro, Pilar Lucas, Silvia F. Soriano, Beatriz Vega, Coloma Costas, M. Ángeles Muñoz-Fernández, César Santiago, José Miguel Rodríguez Frade, Rafael Franco, and Mario Mellado

    PNAS May 13, 2014 111 (19) E1960-E1969; first published April 28, 2014. https://doi.org/10.1073/pnas.1322887111
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    Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges

    Ikuko Fujiwara, Kirsten Remmert, Grzegorz Piszczek, and John A. Hammer

    PNAS May 13, 2014 111 (19) E1970-E1979; first published April 28, 2014. https://doi.org/10.1073/pnas.1313738111
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    Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation

    Noa Rivlin, Shir Katz, Maayan Doody, Michal Sheffer, Stav Horesh, Alina Molchadsky, Gabriela Koifman, Yoav Shetzer, Naomi Goldfinger, Varda Rotter, and Tamar Geiger

    PNAS May 13, 2014 111 (19) 7006-7011; first published April 28, 2014. https://doi.org/10.1073/pnas.1320428111
  • Open Access

    Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase

    • From the Cover

    Leonor Miller-Fleming, Pedro Antas, Teresa Faria Pais, Joshua L. Smalley, Flaviano Giorgini, and Tiago Fleming Outeiro

    PNAS May 13, 2014 111 (19) 7012-7017; first published April 2, 2014. https://doi.org/10.1073/pnas.1319221111

    See companion article:

    • Yeast DJ-1 in metabolism

      - Apr 30, 2014

• Developmental Biology

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    Crumbs promotes expanded recognition and degradation by the SCF^{Slimb/β-TrCP} ubiquitin ligase

    Paulo Ribeiro, Maxine Holder, David Frith, Ambrosius P. Snijders, and Nicolas Tapon

    PNAS May 13, 2014 111 (19) E1980-E1989; first published April 28, 2014. https://doi.org/10.1073/pnas.1315508111
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    Ca_v3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage

    Shin-Shiou Lin, Bing-Hsiean Tzeng, Kuan-Rong Lee, Richard J. H. Smith, Kevin P. Campbell, and Chien-Chang Chen

    PNAS May 13, 2014 111 (19) E1990-E1998; first published April 28, 2014. https://doi.org/10.1073/pnas.1323112111
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    Juvenile hormone regulates body size and perturbs insulin signaling in Drosophila

    Christen Kerry Mirth, Hui Yuan Tang, Sasha C. Makohon-Moore, Samy Salhadar, Rewatee H. Gokhale, Raechel D. Warner, Takashi Koyama, Lynn M. Riddiford, and Alexander W. Shingleton

    PNAS May 13, 2014 111 (19) 7018-7023; first published April 28, 2014. https://doi.org/10.1073/pnas.1313058111
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    Transcription factor E93 specifies adult metamorphosis in hemimetabolous and holometabolous insects

    Enric Ureña, Cristina Manjón, Xavier Franch-Marro, and David Martín

    PNAS May 13, 2014 111 (19) 7024-7029; first published April 28, 2014. https://doi.org/10.1073/pnas.1401478111

• Ecology

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    Network analysis reveals multiscale controls on streamwater chemistry

    Kevin J. McGuire, Christian E. Torgersen, Gene E. Likens, Donald C. Buso, Winsor H. Lowe, and Scott W. Bailey

    PNAS May 13, 2014 111 (19) 7030-7035; first published April 21, 2014. https://doi.org/10.1073/pnas.1404820111
  • Open Access

    Declines in large wildlife increase landscape-level prevalence of rodent-borne disease in Africa

    Hillary S. Young, Rodolfo Dirzo, Kristofer M. Helgen, Douglas J. McCauley, Sarah A. Billeter, Michael Y. Kosoy, Lynn M. Osikowicz, Daniel J. Salkeld, Truman P. Young, and Katharina Dittmar

    PNAS May 13, 2014 111 (19) 7036-7041; first published April 28, 2014. https://doi.org/10.1073/pnas.1404958111

• Environmental Sciences

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    Undocumented water column sink for cadmium in open ocean oxygen-deficient zones

    David J. Janssen, Tim M. Conway, Seth G. John, James R. Christian, Dennis I. Kramer, Tom F. Pedersen, and Jay T. Cullen

    PNAS May 13, 2014 111 (19) 6888-6893; first published April 28, 2014. https://doi.org/10.1073/pnas.1402388111

• Evolution

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    Evolutionary history of redox metal-binding domains across the tree of life

    Arye Harel, Yana Bromberg, Paul G. Falkowski, and Debashish Bhattacharya

    PNAS May 13, 2014 111 (19) 7042-7047; first published April 28, 2014. https://doi.org/10.1073/pnas.1403676111

• Genetics

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    Unusually long-lived pause required for regulation of a Rho-dependent transcription terminator

    Kerry Hollands, Anastasia Sevostiyanova, and Eduardo A. Groisman

    PNAS May 13, 2014 111 (19) E1999-E2007; first published April 28, 2014. https://doi.org/10.1073/pnas.1319193111
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    Microfluidic single-cell whole-transcriptome sequencing

    Aaron M. Streets, Xiannian Zhang, Chen Cao, Yuhong Pang, Xinglong Wu, Liang Xiong, Lu Yang, Yusi Fu, Liang Zhao, Fuchou Tang, and Yanyi Huang

    PNAS May 13, 2014 111 (19) 7048-7053; first published April 29, 2014. https://doi.org/10.1073/pnas.1402030111
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    Lack of testicular seipin causes teratozoospermia syndrome in men

    Min Jiang, Mingming Gao, Chaoming Wu, Hui He, Xuejiang Guo, Zuomin Zhou, Hongyuan Yang, Xinhua Xiao, George Liu, and Jiahao Sha

    PNAS May 13, 2014 111 (19) 7054-7059; first published April 28, 2014. https://doi.org/10.1073/pnas.1324025111
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    Cell cycle-specific cleavage of Scc2 regulates its cohesin deposition activity

    Julie Woodman, Tyler Fara, Monika Dzieciatkowska, Michael Trejo, Nancy Luong, Kirk C. Hansen, and Paul C. Megee

    PNAS May 13, 2014 111 (19) 7060-7065; first published April 28, 2014. https://doi.org/10.1073/pnas.1321722111

• Immunology

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    Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development

    Heon Park, Mark Tsang, Brian M. Iritani, and Michael J. Bevan

    PNAS May 13, 2014 111 (19) 7066-7071; first published April 30, 2014. https://doi.org/10.1073/pnas.1406473111
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    UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5

    Ji-Won Huh, Takuma Shibata, Misun Hwang, Eun-Hye Kwon, Min Seong Jang, Ryutaro Fukui, Atsuo Kanno, Da-Jung Jung, Myoung Ho Jang, Kensuke Miyake, and You-Me Kim

    PNAS May 13, 2014 111 (19) 7072-7077; first published April 28, 2014. https://doi.org/10.1073/pnas.1322838111

• Medical Sciences

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    GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling

    Shuangba He, Chun-Hao Chen, Natalya Chernichenko, Shizhi He, Richard L. Bakst, Fernando Barajas, Sylvie Deborde, Peter J. Allen, Efsevia Vakiani, Zhenkun Yu, and Richard J. Wong

    PNAS May 13, 2014 111 (19) E2008-E2017; first published April 28, 2014. https://doi.org/10.1073/pnas.1402944111
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    Quantification of HIV-1 latency reversal in resting CD4⁺ T cells from patients on suppressive antiretroviral therapy

    • From the Cover

    Anthony R. Cillo, Michele D. Sobolewski, Ronald J. Bosch, Elizabeth Fyne, Michael Piatak Jr., John M. Coffin, and John W. Mellors

    PNAS May 13, 2014 111 (19) 7078-7083; first published March 31, 2014. https://doi.org/10.1073/pnas.1402873111

    See companion article:

    • Measuring reversal of HIV-1 latency ex vivo

      - May 05, 2014
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    Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth

    Dingzhi Wang, Lingchen Fu, Wei Ning, Lixia Guo, Xiaofei Sun, Sudhansu K. Dey, Rupesh Chaturvedi, Keith T. Wilson, and Raymond N. DuBois

    PNAS May 13, 2014 111 (19) 7084-7089; first published April 24, 2014. https://doi.org/10.1073/pnas.1324233111
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    PAI-1–regulated extracellular proteolysis governs senescence and survival in Klotho mice

    Mesut Eren, Amanda E. Boe, Sheila B. Murphy, Aaron T. Place, Varun Nagpal, Luisa Morales-Nebreda, Daniela Urich, Susan E. Quaggin, G. R. Scott Budinger, Gökhan M. Mutlu, Toshio Miyata, and Douglas E. Vaughan

    PNAS May 13, 2014 111 (19) 7090-7095; first published April 28, 2014. https://doi.org/10.1073/pnas.1321942111
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    Histone demethylase KDM5B is a key regulator of genome stability

    Xin Li, Ling Liu, Shangda Yang, Nan Song, Xing Zhou, Jie Gao, Na Yu, Lin Shan, Qian Wang, Jing Liang, Chenghao Xuan, Yan Wang, Yongfeng Shang, and Lei Shi

    PNAS May 13, 2014 111 (19) 7096-7101; first published April 28, 2014. https://doi.org/10.1073/pnas.1324036111

• Microbiology

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    Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution

    Xian-Chun Tang, Sudhakar S. Agnihothram, Yongjun Jiao, Jeremy Stanhope, Rachel L. Graham, Eric C. Peterson, Yuval Avnir, Aimee St. Clair Tallarico, Jared Sheehan, Quan Zhu, Ralph S. Baric, and Wayne A. Marasco

    PNAS May 13, 2014 111 (19) E2018-E2026; first published April 28, 2014. https://doi.org/10.1073/pnas.1402074111
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    Control of type III secretion activity and substrate specificity by the cytoplasmic regulator PcrG

    Pei-Chung Lee, Stephanie Elizabeth Zmina, Charles Morgan Stopford, Jonida Toska, and Arne Rietsch

    PNAS May 13, 2014 111 (19) E2027-E2036; first published April 28, 2014. https://doi.org/10.1073/pnas.1402658111
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    Differential regulation of staphylococcal virulence by the sensor kinase SaeS in response to neutrophil-derived stimuli

    Caralyn E. Flack, Oliwia W. Zurek, Delisha D. Meishery, Kyler B. Pallister, Cheryl L. Malone, Alexander R. Horswill, and Jovanka M. Voyich

    PNAS May 13, 2014 111 (19) E2037-E2045; first published April 29, 2014. https://doi.org/10.1073/pnas.1322125111
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    Bacterial scaffold directs pole-specific centromere segregation

    Jerod L. Ptacin, Andreas Gahlmann, Grant R. Bowman, Adam M. Perez, Alexander R. S. von Diezmann, Michael R. Eckart, W. E. Moerner, and Lucy Shapiro

    PNAS May 13, 2014 111 (19) E2046-E2055; first published April 28, 2014. https://doi.org/10.1073/pnas.1405188111
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    A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria

    Peter Spanogiannopoulos, Nicholas Waglechner, Kalinka Koteva, and Gerard D. Wright

    PNAS May 13, 2014 111 (19) 7102-7107; first published April 28, 2014. https://doi.org/10.1073/pnas.1402358111
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    Drosha as an interferon-independent antiviral factor

    Jillian S. Shapiro, Sonja Schmid, Lauren C. Aguado, Leah R. Sabin, Ari Yasunaga, Jaehee V. Shim, David Sachs, Sara Cherry, and Benjamin R. tenOever

    PNAS May 13, 2014 111 (19) 7108-7113; first published April 28, 2014. https://doi.org/10.1073/pnas.1319635111
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    Pathophysiology of hantavirus pulmonary syndrome in rhesus macaques

    David Safronetz, Joseph Prescott, Friederike Feldmann, Elaine Haddock, Rebecca Rosenke, Atsushi Okumura, Douglas Brining, Eric Dahlstrom, Stephen F. Porcella, Hideki Ebihara, Dana P. Scott, Brian Hjelle, and Heinz Feldmann

    PNAS May 13, 2014 111 (19) 7114-7119; first published April 28, 2014. https://doi.org/10.1073/pnas.1401998111

• Neuroscience

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    Visuospatial selective attention in chickens

    Devarajan Sridharan, Deepa L. Ramamurthy, Jason S. Schwarz, and Eric I. Knudsen

    PNAS May 13, 2014 111 (19) E2056-E2065; first published April 21, 2014. https://doi.org/10.1073/pnas.1316824111
  • Open Access

    Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia

    Shashwath A. Meda, Gualberto Ruaño, Andreas Windemuth, Kasey O’Neil, Clifton Berwise, Sabra M. Dunn, Leah E. Boccaccio, Balaji Narayanan, Mohan Kocherla, Emma Sprooten, Matcheri S. Keshavan, Carol A. Tamminga, John A. Sweeney, Brett A. Clementz, Vince D. Calhoun, and Godfrey D. Pearlson

    PNAS May 13, 2014 111 (19) E2066-E2075; first published April 28, 2014. https://doi.org/10.1073/pnas.1313093111
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    Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

    Xiang Li, Wei Wei, Qiong-Yi Zhao, Jocelyn Widagdo, Danay Baker-Andresen, Charlotte R. Flavell, Ana D’Alessio, Yi Zhang, and Timothy W. Bredy

    PNAS May 13, 2014 111 (19) 7120-7125; first published April 22, 2014. https://doi.org/10.1073/pnas.1318906111
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    Noise differentially impacts phoneme representations in the auditory and speech motor systems

    Yi Du, Bradley R. Buchsbaum, Cheryl L. Grady, and Claude Alain

    PNAS May 13, 2014 111 (19) 7126-7131; first published April 28, 2014. https://doi.org/10.1073/pnas.1318738111
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    Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABA_A receptors

    Armen M. Abramian, Eydith Comenencia-Ortiz, Amit Modgil, Thuy N. Vien, Yasuko Nakamura, Yvonne E. Moore, Jamie L. Maguire, Miho Terunuma, Paul A. Davies, and Stephen J. Moss

    PNAS May 13, 2014 111 (19) 7132-7137; first published April 28, 2014. https://doi.org/10.1073/pnas.1403285111
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    GAL₃ receptor KO mice exhibit an anxiety-like phenotype

    Susanne M. Brunner, Aitak Farzi, Felix Locker, Barbara S. Holub, Meinrad Drexel, Florian Reichmann, Andreas A. Lang, Johannes A. Mayr, Jorge J. Vilches, Xavier Navarro, Roland Lang, Günther Sperk, Peter Holzer, and Barbara Kofler

    PNAS May 13, 2014 111 (19) 7138-7143; first published April 29, 2014. https://doi.org/10.1073/pnas.1318066111

• Plant Biology

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    Intake and transformation to a glycoside of (Z)-3-hexenol from infested neighbors reveals a mode of plant odor reception and defense

    • From the Cover

    Koichi Sugimoto, Kenji Matsui, Yoko Iijima, Yoshihiko Akakabe, Shoko Muramoto, Rika Ozawa, Masayoshi Uefune, Ryosuke Sasaki, Kabir Md. Alamgir, Shota Akitake, Tatsunori Nobuke, Ivan Galis, Koh Aoki, Daisuke Shibata, and Junji Takabayashi

    PNAS May 13, 2014 111 (19) 7144-7149; first published April 28, 2014. https://doi.org/10.1073/pnas.1320660111
  • Open Access

    Arabidopsis ABCG14 is essential for the root-to-shoot translocation of cytokinin

    Donghwi Ko, Joohyun Kang, Takatoshi Kiba, Jiyoung Park, Mikiko Kojima, Jihye Do, Kyung Yoon Kim, Mi Kwon, Anne Endler, Won-Yong Song, Enrico Martinoia, Hitoshi Sakakibara, and Youngsook Lee

    PNAS May 13, 2014 111 (19) 7150-7155; first published April 28, 2014. https://doi.org/10.1073/pnas.1321519111

• Systems Biology

  • Open Access

    Controllability in protein interaction networks

    Stefan Wuchty

    PNAS May 13, 2014 111 (19) 7156-7160; first published April 28, 2014. https://doi.org/10.1073/pnas.1311231111