Table of Contents

Biological Sciences

• Anthropology

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    Temporal labyrinths of eastern Eurasian Pleistocene humans

    Xiu-Jie Wu, Isabelle Crevecoeur, Wu Liu, Song Xing, and Erik Trinkaus

    PNAS July 22, 2014 111 (29) 10509-10513; first published July 7, 2014. https://doi.org/10.1073/pnas.1410735111

• Applied Biological Sciences

  • Open Access

    Device design and materials optimization of conformal coating for islets of Langerhans

    • From the Cover

    Alice A. Tomei, Vita Manzoli, Christopher A. Fraker, Jaime Giraldo, Diana Velluto, Mejdi Najjar, Antonello Pileggi, R. Damaris Molano, Camillo Ricordi, Cherie L. Stabler, and Jeffrey A. Hubbell

    PNAS July 22, 2014 111 (29) 10514-10519; first published June 30, 2014. https://doi.org/10.1073/pnas.1402216111

• Biochemistry

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    Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3

    Jacob A. Galan, Kathryn M. Geraghty, Geneviève Lavoie, Evgeny Kanshin, Joseph Tcherkezian, Viviane Calabrese, Grace R. Jeschke, Benjamin E. Turk, Bryan A. Ballif, John Blenis, Pierre Thibault, and Philippe P. Roux

    PNAS July 22, 2014 111 (29) E2918-E2927; first published July 7, 2014. https://doi.org/10.1073/pnas.1405601111
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    DEAD-box protein CYT-19 is activated by exposed helices in a group I intron RNA

    Inga Jarmoskaite, Hari Bhaskaran, Soenke Seifert, and Rick Russell

    PNAS July 22, 2014 111 (29) E2928-E2936; first published July 7, 2014. https://doi.org/10.1073/pnas.1404307111
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    Molecular mechanisms for the regulation of histone mRNA stem-loop–binding protein by phosphorylation

    Jun Zhang, Dazhi Tan, Eugene F. DeRose, Lalith Perera, Zbigniew Dominski, William F. Marzluff, Liang Tong, and Traci M. Tanaka Hall

    PNAS July 22, 2014 111 (29) E2937-E2946; first published July 7, 2014. https://doi.org/10.1073/pnas.1406381111
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    Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi

    • Inaugural Article

    Matthew B. Lohse, Oren S. Rosenberg, Jeffery S. Cox, Robert M. Stroud, Janet S. Finer-Moore, and Alexander D. Johnson

    PNAS July 22, 2014 111 (29) 10404-10410; first published July 3, 2014. https://doi.org/10.1073/pnas.1410110111

    See companion article:

    • Profile of Alexander D. Johnson

      - Aug 11, 2014
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    Ancient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaea

    Yuchen Liu, Akiyoshi Nakamura, Yuto Nakazawa, Nozomi Asano, Kara A. Ford, Michael J. Hohn, Isao Tanaka, Min Yao, and Dieter Söll

    PNAS July 22, 2014 111 (29) 10520-10525; first published July 7, 2014. https://doi.org/10.1073/pnas.1411267111
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    Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

    Ulrich Schweizer, Christine Schlicker, Doreen Braun, Josef Köhrle, and Clemens Steegborn

    PNAS July 22, 2014 111 (29) 10526-10531; first published July 7, 2014. https://doi.org/10.1073/pnas.1323873111
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    Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

    Joshua B. Parsons, Tyler C. Broussard, Jeffrey L. Bose, Jason W. Rosch, Pamela Jackson, Chitra Subramanian, and Charles O. Rock

    PNAS July 22, 2014 111 (29) 10532-10537; first published July 7, 2014. https://doi.org/10.1073/pnas.1408797111
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    The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling

    FoSheng Hsu, Xi Luo, Jiazhang Qiu, Yan-Bin Teng, Jianping Jin, Marcus B. Smolka, Zhao-Qing Luo, and Yuxin Mao

    PNAS July 22, 2014 111 (29) 10538-10543; first published July 8, 2014. https://doi.org/10.1073/pnas.1402605111
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    Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

    Koji Takeo, Shun Tanimura, Takehiro Shinoda, Satoko Osawa, Ivan Krasmirov Zahariev, Naoki Takegami, Yoshiko Ishizuka-Katsura, Naoko Shinya, Shizuka Takagi-Niidome, Aya Tominaga, Noboru Ohsawa, Tomomi Kimura-Someya, Mikako Shirouzu, Satoshi Yokoshima, Shigeyuki Yokoyama, Tohru Fukuyama, Taisuke Tomita, and Takeshi Iwatsubo

    PNAS July 22, 2014 111 (29) 10544-10549; first published July 9, 2014. https://doi.org/10.1073/pnas.1402171111

• Biophysics and Computational Biology

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    Catalytic strategy used by the myosin motor to hydrolyze ATP

    Farooq Ahmad Kiani and Stefan Fischer

    PNAS July 22, 2014 111 (29) E2947-E2956; first published July 8, 2014. https://doi.org/10.1073/pnas.1401862111
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    SERS and MD simulation studies of a kinase inhibitor demonstrate the emergence of a potential drug discovery tool

    Dhanasekaran Karthigeyan, Soumik Siddhanta, Annavarapu Hari Kishore, Sathya S. R. R. Perumal, Hans Ågren, Surabhi Sudevan, Akshay V. Bhat, Karanam Balasubramanyam, Rangappa Kanchugarakoppal Subbegowda, Tapas K. Kundu, and Chandrabhas Narayana

    PNAS July 22, 2014 111 (29) 10416-10421; first published June 27, 2014. https://doi.org/10.1073/pnas.1402695111
  • Open Access

    Unusual kinetics of thermal decay of dim-light photoreceptors in vertebrate vision

    Ying Guo, Sivakumar Sekharan, Jian Liu, Victor S. Batista, John C. Tully, and Elsa C. Y. Yan

    PNAS July 22, 2014 111 (29) 10438-10443; first published July 7, 2014. https://doi.org/10.1073/pnas.1410826111
  • Open Access

    Energy landscape views for interplays among folding, binding, and allostery of calmodulin domains

    Wenfei Li, Wei Wang, and Shoji Takada

    PNAS July 22, 2014 111 (29) 10550-10555; first published July 7, 2014. https://doi.org/10.1073/pnas.1402768111
  • Open Access

    Simple chained guide trees give high-quality protein multiple sequence alignments

    Kieran Boyce, Fabian Sievers, and Desmond G. Higgins

    PNAS July 22, 2014 111 (29) 10556-10561; first published July 7, 2014. https://doi.org/10.1073/pnas.1405628111

    See companion article:

    • Real and simulated proteins in MSAs

      - Jan 06, 2015
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    Modulation of frustration in folding by sequence permutation

    R. Paul Nobrega, Karunesh Arora, Sagar V. Kathuria, Rita Graceffa, Raul A. Barrea, Liang Guo, Srinivas Chakravarthy, Osman Bilsel, Thomas C. Irving, Charles L. Brooks III, and C. Robert Matthews

    PNAS July 22, 2014 111 (29) 10562-10567; first published July 7, 2014. https://doi.org/10.1073/pnas.1324230111

• Cell Biology

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    Ras transformation uncouples the kinesin-coordinated cellular nutrient response

    Elma Zaganjor, Lauren M. Weil, Joshua X. Gonzales, John D. Minna, and Melanie H. Cobb

    PNAS July 22, 2014 111 (29) 10568-10573; first published July 7, 2014. https://doi.org/10.1073/pnas.1411016111
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    Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

    Andreas Janzer, Natalie J. German, Karina N. Gonzalez-Herrera, John M. Asara, Marcia C. Haigis, and Kevin Struhl

    PNAS July 22, 2014 111 (29) 10574-10579; first published July 7, 2014. https://doi.org/10.1073/pnas.1409844111
  • Open Access

    An uncoupling channel within the c-subunit ring of the F₁F_O ATP synthase is the mitochondrial permeability transition pore

    • From the Cover

    Kambiz N. Alavian, Gisela Beutner, Emma Lazrove, Silvio Sacchetti, Han-A Park, Pawel Licznerski, Hongmei Li, Panah Nabili, Kathryn Hockensmith, Morven Graham, George A. Porter Jr., and Elizabeth A. Jonas

    PNAS July 22, 2014 111 (29) 10580-10585; first published June 16, 2014. https://doi.org/10.1073/pnas.1401591111

    See companion article:

    • Mitochondrial pore rediscovered

      - Jul 07, 2014
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    TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy

    Ariadne Vlahakis, Martin Graef, Jodi Nunnari, and Ted Powers

    PNAS July 22, 2014 111 (29) 10586-10591; first published July 7, 2014. https://doi.org/10.1073/pnas.1406305111
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    Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells

    Ronan Quéré, Laetitia Saint-Paul, Virginie Carmignac, Romain Z. Martin, Marie-Lorraine Chrétien, Anne Largeot, Arlette Hammann, Jean-Paul Pais de Barros, Jean-Noël Bastie, and Laurent Delva

    PNAS July 22, 2014 111 (29) 10592-10597; first published July 7, 2014. https://doi.org/10.1073/pnas.1405546111

• Developmental Biology

  • Open Access

    Dynamic regulation of eve stripe 2 expression reveals transcriptional bursts in living Drosophila embryos

    Jacques P. Bothma, Hernan G. Garcia, Emilia Esposito, Gavin Schlissel, Thomas Gregor, and Michael Levine

    PNAS July 22, 2014 111 (29) 10598-10603; first published July 3, 2014. https://doi.org/10.1073/pnas.1410022111

• Ecology

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    Role of projection in the control of bird flocks

    Daniel J. G. Pearce, Adam M. Miller, George Rowlands, and Matthew S. Turner

    PNAS July 22, 2014 111 (29) 10422-10426; first published July 7, 2014. https://doi.org/10.1073/pnas.1402202111
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    Environmental impact of geometric earthwork construction in pre-Columbian Amazonia

    John Francis Carson, Bronwen S. Whitney, Francis E. Mayle, José Iriarte, Heiko Prümers, J. Daniel Soto, and Jennifer Watling

    PNAS July 22, 2014 111 (29) 10497-10502; first published July 7, 2014. https://doi.org/10.1073/pnas.1321770111

    See companion article:

    • Reply to Silva: South American ecotonal dynamics

      - Aug 26, 2014
  • Open Access

    The role of older children and adults in wild poliovirus transmission

    • From the Cover

    Isobel M. Blake, Rebecca Martin, Ajay Goel, Nino Khetsuriani, Johannes Everts, Christopher Wolff, Steven Wassilak, R. Bruce Aylward, and Nicholas C. Grassly

    PNAS July 22, 2014 111 (29) 10604-10609; first published July 7, 2014. https://doi.org/10.1073/pnas.1323688111
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    Invasive plants have broader physiological niches

    Steven I. Higgins and David M. Richardson

    PNAS July 22, 2014 111 (29) 10610-10614; first published July 2, 2014. https://doi.org/10.1073/pnas.1406075111

• Environmental Sciences

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    Herbarium specimens show contrasting phenological responses to Himalayan climate

    Robbie Hart, Jan Salick, Sailesh Ranjitkar, and Jianchu Xu

    PNAS July 22, 2014 111 (29) 10615-10619; first published July 7, 2014. https://doi.org/10.1073/pnas.1403376111

• Evolution

  • Open Access

    The fossilized birth–death process for coherent calibration of divergence-time estimates

    Tracy A. Heath, John P. Huelsenbeck, and Tanja Stadler

    PNAS July 22, 2014 111 (29) E2957-E2966; first published July 9, 2014. https://doi.org/10.1073/pnas.1319091111
  • Open Access

    Algorithms, games, and evolution

    • From the Cover

    Erick Chastain, Adi Livnat, Christos Papadimitriou, and Umesh Vazirani

    PNAS July 22, 2014 111 (29) 10620-10623; first published June 16, 2014. https://doi.org/10.1073/pnas.1406556111

    See companion article:

    • Selection in evolution and computer science

      - Jul 09, 2014
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    Flight performance of the largest volant bird

    Daniel T. Ksepka

    PNAS July 22, 2014 111 (29) 10624-10629; first published July 7, 2014. https://doi.org/10.1073/pnas.1320297111
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    Divergence of Drosophila melanogaster repeatomes in response to a sharp microclimate contrast in Evolution Canyon, Israel

    Young Bun Kim, Jung Hun Oh, Lauren J. McIver, Eugenia Rashkovetsky, Katarzyna Michalak, Harold R. Garner, Lin Kang, Eviatar Nevo, Abraham B. Korol, and Pawel Michalak

    PNAS July 22, 2014 111 (29) 10630-10635; first published July 8, 2014. https://doi.org/10.1073/pnas.1410372111
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    Drastic population fluctuations explain the rapid extinction of the passenger pigeon

    • From the Cover

    Chih-Ming Hung, Pei-Jen L. Shaner, Robert M. Zink, Wei-Chung Liu, Te-Chin Chu, Wen-San Huang, and Shou-Hsien Li

    PNAS July 22, 2014 111 (29) 10636-10641; first published June 16, 2014. https://doi.org/10.1073/pnas.1401526111

    See companion article:

    • Range and population in an extinct bird

      - Jun 30, 2014

• Genetics

  • Open Access

    Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila

    Fillip Port, Hui-Min Chen, Tzumin Lee, and Simon L. Bullock

    PNAS July 22, 2014 111 (29) E2967-E2976; first published July 7, 2014. https://doi.org/10.1073/pnas.1405500111
  • Open Access

    Mutation of a major CG methylase in rice causes genome-wide hypomethylation, dysregulated genome expression, and seedling lethality

    Lanjuan Hu, Ning Li, Chunming Xu, Silin Zhong, Xiuyun Lin, Jingjing Yang, Tianqi Zhou, Anzhi Yuliang, Ying Wu, Yun-Ru Chen, Xiaofeng Cao, Assaf Zemach, Sachin Rustgi, Diter von Wettstein, and Bao Liu

    PNAS July 22, 2014 111 (29) 10642-10647; first published July 7, 2014. https://doi.org/10.1073/pnas.1410761111
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    FGF5 is a crucial regulator of hair length in humans

    Claire A. Higgins, Lynn Petukhova, Sivan Harel, Yuan Y. Ho, Esther Drill, Lawrence Shapiro, Muhammad Wajid, and Angela M. Christiano

    PNAS July 22, 2014 111 (29) 10648-10653; first published July 2, 2014. https://doi.org/10.1073/pnas.1402862111
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    Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals

    Kaixiong Ye, Jian Lu, Fei Ma, Alon Keinan, and Zhenglong Gu

    PNAS July 22, 2014 111 (29) 10654-10659; first published July 7, 2014. https://doi.org/10.1073/pnas.1403521111

    See companion article:

    • MPS and mitochondrial heteroplasmy

      - Oct 15, 2014

• Immunology and Inflammation

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    Adaptive immunity to murine skin commensals

    Wei Shen, Wenqing Li, Julie A. Hixon, Nicolas Bouladoux, Yasmine Belkaid, Amiran Dzutzev, and Scott K. Durum

    PNAS July 22, 2014 111 (29) E2977-E2986; first published July 7, 2014. https://doi.org/10.1073/pnas.1401820111
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    Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

    Pappanaicken R. Kumaresan, Pallavi R. Manuri, Nathaniel D. Albert, Sourindra Maiti, Harjeet Singh, Tiejuan Mi, Jason Roszik, Brian Rabinovich, Simon Olivares, Janani Krishnamurthy, Ling Zhang, Amer M. Najjar, M. Helen Huls, Dean A. Lee, Richard E. Champlin, Dimitrios P. Kontoyiannis, and Laurence J. N. Cooper

    PNAS July 22, 2014 111 (29) 10660-10665; first published July 7, 2014. https://doi.org/10.1073/pnas.1312789111
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    25-Hydroxycholesterol acts as an amplifier of inflammatory signaling

    Elizabeth S. Gold, Alan H. Diercks, Irina Podolsky, Rebecca L. Podyminogin, Peter S. Askovich, Piper M. Treuting, and Alan Aderem

    PNAS July 22, 2014 111 (29) 10666-10671; first published July 3, 2014. https://doi.org/10.1073/pnas.1404271111
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    Commensal microbes drive intestinal inflammation by IL-17–producing CD4⁺ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2

    Lijun Xin, Tony T. Jiang, Vandana Chaturvedi, Jeremy M. Kinder, James M. Ertelt, Jared H. Rowe, Kris A. Steinbrecher, and Sing Sing Way

    PNAS July 22, 2014 111 (29) 10672-10677; first published July 7, 2014. https://doi.org/10.1073/pnas.1402336111

• Medical Sciences

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    Detouring of cisplatin to access mitochondrial genome for overcoming resistance

    Sean Marrache, Rakesh K. Pathak, and Shanta Dhar

    PNAS July 22, 2014 111 (29) 10444-10449; first published July 7, 2014. https://doi.org/10.1073/pnas.1405244111
  • Open Access

    Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells

    Sen Wu, Yuanyuan Wu, Xi Zhang, and Mario R. Capecchi

    PNAS July 22, 2014 111 (29) 10678-10683; first published July 7, 2014. https://doi.org/10.1073/pnas.1409933111
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    Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

    Ping Zhang, Bo Tu, Hua Wang, Ziyang Cao, Ming Tang, Chaohua Zhang, Bo Gu, Zhiming Li, Lina Wang, Yang Yang, Ying Zhao, Haiying Wang, Jianyuan Luo, Chu-Xia Deng, Bin Gao, Robert G. Roeder, and Wei-Guo Zhu

    PNAS July 22, 2014 111 (29) 10684-10689; first published July 9, 2014. https://doi.org/10.1073/pnas.1411026111

    See companion article:

    • Focus on PCK

      - Sep 26, 2014
  • Open Access

    Discrete conformations of epitope II on the hepatitis C virus E2 protein for antibody-mediated neutralization and nonneutralization

    Lu Deng, Li Ma, Maria Luisa Virata, Lilin Zhong, Hailing Yan, Zhong Zhao, Evi Struble, Stephen Feinstone, Harvey Alter, and Pei Zhang

    PNAS July 22, 2014 111 (29) 10690-10695; first published July 7, 2014. https://doi.org/10.1073/pnas.1411317111
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    G-CSF Induces Membrane Expression of a Myeloperoxidase Glycovariant that Operates as an E-selectin Ligand on Human Myeloid Cells

    Cristina I. Silvescu and Robert Sackstein

    PNAS July 22, 2014 111 (29) 10696-10701; first published July 7, 2014. https://doi.org/10.1073/pnas.1320833111

• Microbiology

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    Rhizobial homologs of the fatty acid transporter FadL facilitate perception of long-chain acyl-homoserine lactone signals

    Elizaveta Krol and Anke Becker

    PNAS July 22, 2014 111 (29) 10702-10707; first published July 7, 2014. https://doi.org/10.1073/pnas.1404929111
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    Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs

    Dal Young Kim, Svetlana Atasheva, Alexander J. McAuley, Jessica A. Plante, Elena I. Frolova, David W. C. Beasley, and Ilya Frolov

    PNAS July 22, 2014 111 (29) 10708-10713; first published July 7, 2014. https://doi.org/10.1073/pnas.1408677111
  • Open Access

    Modeling ecological drivers in marine viral communities using comparative metagenomics and network analyses

    Bonnie L. Hurwitz, Anton H. Westveld, Jennifer R. Brum, and Matthew B. Sullivan

    PNAS July 22, 2014 111 (29) 10714-10719; first published July 7, 2014. https://doi.org/10.1073/pnas.1319778111

• Neuroscience

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    Astrocyte activation is suppressed in both normal and injured brain by FGF signaling

    Wenfei Kang, Francesca Balordi, Nan Su, Lin Chen, Gordon Fishell, and Jean M. Hébert

    PNAS July 22, 2014 111 (29) E2987-E2995; first published July 7, 2014. https://doi.org/10.1073/pnas.1320401111
  • Open Access

    Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner

    Yibo Qu, Yuhua Huang, Jia Feng, Gonzalo Alvarez-Bolado, Elizabeth A. Grove, Yingzi Yang, Fadel Tissir, Libing Zhou, and Andre M. Goffinet

    PNAS July 22, 2014 111 (29) E2996-E3004; first published July 7, 2014. https://doi.org/10.1073/pnas.1402105111

    See companion article:

    • Frizzled3 in axon growth and guidance

      - May 05, 2014
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    Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system

    Zhong L. Hua, Sangmin Jeon, Michael J. Caterina, and Jeremy Nathans

    PNAS July 22, 2014 111 (29) E3005-E3014; first published May 5, 2014. https://doi.org/10.1073/pnas.1406399111

    See companion article:

    • Celsr and forebrain wiring

      - Jul 07, 2014
  • Open Access

    Irrational exuberance and neural crash warning signals during endogenous experimental market bubbles

    Alec Smith, Terry Lohrenz, Justin King, P. Read Montague, and Colin F. Camerer

    PNAS July 22, 2014 111 (29) 10503-10508; first published July 7, 2014. https://doi.org/10.1073/pnas.1318416111
  • Open Access

    CA3 size predicts the precision of memory recall

    Martin J. Chadwick, Heidi M. Bonnici, and Eleanor A. Maguire

    PNAS July 22, 2014 111 (29) 10720-10725; first published July 7, 2014. https://doi.org/10.1073/pnas.1319641111
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    The transcription factor Fezf2 directs the differentiation of neural stem cells in the subventricular zone toward a cortical phenotype

    Annalisa Zuccotti, Corentin Le Magueresse, Min Chen, Angela Neitz, and Hannah Monyer

    PNAS July 22, 2014 111 (29) 10726-10731; first published July 7, 2014. https://doi.org/10.1073/pnas.1320290111
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    Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

    Amanda N. Sacino, Mieu Brooks, Michael A. Thomas, Alex B. McKinney, Sooyeon Lee, Robert W. Regenhardt, Nicholas H. McGarvey, Jacob I. Ayers, Lucia Notterpek, David R. Borchelt, Todd E. Golde, and Benoit I. Giasson

    PNAS July 22, 2014 111 (29) 10732-10737; first published July 7, 2014. https://doi.org/10.1073/pnas.1321785111
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    Neural correlates of auditory streaming in an objective behavioral task

    Naoya Itatani and Georg M. Klump

    PNAS July 22, 2014 111 (29) 10738-10743; first published July 7, 2014. https://doi.org/10.1073/pnas.1321487111

• Pharmacology

  • Open Access

    Covalent agonists for studying G protein-coupled receptor activation

    Dietmar Weichert, Andrew C. Kruse, Aashish Manglik, Christine Hiller, Cheng Zhang, Harald Hübner, Brian K. Kobilka, and Peter Gmeiner

    PNAS July 22, 2014 111 (29) 10744-10748; first published July 8, 2014. https://doi.org/10.1073/pnas.1410415111
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    Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein

    Katarzyna Kaczanowska, Michal Harel, Zoran Radić, Jean-Pierre Changeux, M. G. Finn, and Palmer Taylor

    PNAS July 22, 2014 111 (29) 10749-10754; first published July 8, 2014. https://doi.org/10.1073/pnas.1410992111
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    Mechanisms underlying the activation of G-protein–gated inwardly rectifying K⁺ (GIRK) channels by the novel anxiolytic drug, ML297

    Nicole Wydeven, Ezequiel Marron Fernandez de Velasco, Yu Du, Michael A. Benneyworth, Matthew C. Hearing, Rachel A. Fischer, Mark John Thomas, C. David Weaver, and Kevin Wickman

    PNAS July 22, 2014 111 (29) 10755-10760; first published July 7, 2014. https://doi.org/10.1073/pnas.1405190111

• Physiology

  • Open Access

    Effect of sleep deprivation on the human metabolome

    Sarah K. Davies, Joo Ern Ang, Victoria L. Revell, Ben Holmes, Anuska Mann, Francesca P. Robertson, Nanyi Cui, Benita Middleton, Katrin Ackermann, Manfred Kayser, Alfred E. Thumser, Florence I. Raynaud, and Debra J. Skene

    PNAS July 22, 2014 111 (29) 10761-10766; first published July 7, 2014. https://doi.org/10.1073/pnas.1402663111

• Plant Biology

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    Auxin inhibits stomatal development through MONOPTEROS repression of a mobile peptide gene STOMAGEN in mesophyll

    Jing-Yi Zhang, Sheng-Bo He, Ling Li, and Hong-Quan Yang

    PNAS July 22, 2014 111 (29) E3015-E3023; first published July 7, 2014. https://doi.org/10.1073/pnas.1400542111

• Population Biology

  • Open Access

    Contact between bird species of different lifespans can promote the emergence of highly pathogenic avian influenza strains

    Paul S. Wikramaratna, Oliver G. Pybus, and Sunetra Gupta

    PNAS July 22, 2014 111 (29) 10767-10772; first published June 23, 2014. https://doi.org/10.1073/pnas.1401849111

• Systems Biology

  • Open Access

    Intratumor heterogeneity alters most effective drugs in designed combinations

    Boyang Zhao, Michael T. Hemann, and Douglas A. Lauffenburger

    PNAS July 22, 2014 111 (29) 10773-10778; first published July 7, 2014. https://doi.org/10.1073/pnas.1323934111

    See companion article:

    • Drug combinations for heterogeneous tumors

      - Sep 24, 2014