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Research Article

Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity

Nora D. Volkow, Gene-Jack Wang, Frank Telang, Joanna S. Fowler, David Alexoff, Jean Logan, Millard Jayne, Christopher Wong, and Dardo Tomasi
PNAS July 29, 2014 111 (30) E3149-E3156; first published July 14, 2014; https://doi.org/10.1073/pnas.1411228111
Nora D. Volkow
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20857;
bNational Institute on Drug Abuse, Rockville, MD 20857;
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  • For correspondence: nvolkow@nida.nih.gov fowler@bnl.gov
Gene-Jack Wang
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20857;
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Frank Telang
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20857;
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Joanna S. Fowler
cBiosciences Department, Brookhaven National Laboratory, Upton, NY 11973; and
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  • For correspondence: nvolkow@nida.nih.gov fowler@bnl.gov
David Alexoff
cBiosciences Department, Brookhaven National Laboratory, Upton, NY 11973; and
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Jean Logan
dDepartment of Radiology, New York University Langone Medical Center, New York, NY 10016
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Millard Jayne
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20857;
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Christopher Wong
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20857;
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Dardo Tomasi
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20857;
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  1. Contributed by Joanna S. Fowler, June 20, 2014 (sent for review April 9, 2014; reviewed by Bertha Madras, Harvard University Medical School, and Karen Berman, National Institute of Mental Health)

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    - Aug 11, 2014
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Article Information

vol. 111 no. 30 E3149-E3156
DOI: 
https://doi.org/10.1073/pnas.1411228111
PubMed: 
25024177

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue July 29, 2014.
  • Published first July 14, 2014.

Copyright & Usage: 
Freely available online through the PNAS open access option.

Author Information

  1. Nora D. Volkowa,b,1,
  2. Gene-Jack Wanga,
  3. Frank Telanga,
  4. Joanna S. Fowlerc,1,
  5. David Alexoffc,
  6. Jean Logand,
  7. Millard Jaynea,
  8. Christopher Wonga, and
  9. Dardo Tomasia
  1. aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20857;
  2. bNational Institute on Drug Abuse, Rockville, MD 20857;
  3. cBiosciences Department, Brookhaven National Laboratory, Upton, NY 11973; and
  4. dDepartment of Radiology, New York University Langone Medical Center, New York, NY 10016
  1. Contributed by Joanna S. Fowler, June 20, 2014 (sent for review April 9, 2014; reviewed by Bertha Madras, Harvard University Medical School, and Karen Berman, National Institute of Mental Health)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: nvolkow{at}nida.nih.gov or fowler{at}bnl.gov.
  • Author contributions: N.D.V., G.-J.W., and J.S.F. designed research; G.-J.W., F.T., D.A., and M.J. performed research; D.A. contributed new reagents/analytic tools; M.J. recruited and screened volunteers; N.D.V., G.-J.W., J.L., C.W., and D.T. analyzed data; and N.D.V. and J.S.F. wrote the paper.

  • No author conflict of interest response is available.

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Article usage

Article usage: July 2014 to January 2021

AbstractFullPdf
Jul 201424088923618
Aug 20144408386486
Sep 20142382414245
Oct 20141900371199
Nov 20142260546288
Dec 20141406303139
Total 20143644421124975
Jan 20151188236137
Feb 20151035275120
Mar 2015994277139
Apr 2015848256140
May 2015606147113
Jun 201550210573
Jul 2015693137106
Aug 2015540132117
Sep 2015835234232
Oct 2015939271427
Nov 2015858275404
Dec 2015587219193
Total 2015962525642201
Jan 2016805140194
Feb 2016520143197
Mar 2016626162327
Apr 2016714128284
May 201651382184
Jun 2016379157167
Jul 20161428235207
Aug 201658470184
Sep 2016675101116
Oct 2016795237218
Nov 2016873223224
Dec 201652022592
Total 2016843219032394
Jan 201759626267
Feb 201764362697
Mar 2017775353207
Apr 2017992202119
May 2017757150111
Jun 20175479971
Jul 201749210161
Aug 20174099473
Sep 2017465208176
Oct 2017536198141
Nov 2017593231121
Dec 201744515768
Total 2017725026811312
Jan 201853014446
Feb 2018601275100
Mar 2018816520140
Apr 2018621378126
May 20181450124390
Jun 201899668359
Jul 20181233330128
Aug 201860836892
Sep 201854234186
Oct 2018343450168
Nov 2018279506127
Dec 201819553378
Total 2018821457711240
Jan 2019184447103
Feb 2019250421137
Mar 2019318366155
Apr 2019237347160
May 2019177270148
Jun 201911525565
Jul 2019140267123
Aug 201911432692
Sep 2019175266101
Oct 2019233329138
Nov 2019216327147
Dec 2019241296110
Total 2019240039171479
Jan 2020157283103
Feb 2020218273116
Mar 2020205322131
Apr 2020263400148
May 2020327352129
Jun 2020191392105
Jul 2020134473102
Aug 202012451895
Sep 2020158580147
Oct 2020323672172
Nov 2020283746162
Dec 2020224692165
Total 2020260757031575
Jan 20215239444
Total 20215239444
Total750242504515220
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Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity
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Decreased brain DA reactivity in marijuana abusers
Nora D. Volkow, Gene-Jack Wang, Frank Telang, Joanna S. Fowler, David Alexoff, Jean Logan, Millard Jayne, Christopher Wong, Dardo Tomasi
Proceedings of the National Academy of Sciences Jul 2014, 111 (30) E3149-E3156; DOI: 10.1073/pnas.1411228111

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Decreased brain DA reactivity in marijuana abusers
Nora D. Volkow, Gene-Jack Wang, Frank Telang, Joanna S. Fowler, David Alexoff, Jean Logan, Millard Jayne, Christopher Wong, Dardo Tomasi
Proceedings of the National Academy of Sciences Jul 2014, 111 (30) E3149-E3156; DOI: 10.1073/pnas.1411228111
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Proceedings of the National Academy of Sciences: 111 (30)
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