Proceedings of the National Academy of Sciences: 111 (34)

New Research In

August 26, 2014; vol. 111 no. 34

This Week in PNAS

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In This Issue
PNAS August 26, 2014 111 (34) 12271-12272; https://doi.org/10.1073/iti3414111

Letters (Online Only)

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Female hurricanes are not deadlier than male hurricanes
Daniel Malter

PNAS August 26, 2014 111 (34) E3496; first published August 4, 2014. https://doi.org/10.1073/pnas.1411428111
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Are female hurricanes really deadlier than male hurricanes?
Björn Christensen and Sören Christensen

PNAS August 26, 2014 111 (34) E3497-E3498; first published August 4, 2014. https://doi.org/10.1073/pnas.1410910111
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Reply to Christensen and Christensen and to Malter: Pitfalls of erroneous analyses of hurricanes names
Kiju Jung, Sharon Shavitt, Madhu Viswanathan, and Joseph M. Hilbe

PNAS August 26, 2014 111 (34) E3499-E3500; first published August 4, 2014. https://doi.org/10.1073/pnas.1411652111

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: 1885, the first rabies vaccination in humans
Front Matter
Rino Rappuoli

PNAS August 26, 2014 111 (34) 12273; https://doi.org/10.1073/pnas.1414226111

Commentaries

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Pharmacological chaperones in the age of proteomic pathology
Scott A. Small

PNAS August 26, 2014 111 (34) 12274-12275; first published August 13, 2014. https://doi.org/10.1073/pnas.1413111111
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Clovis at the end of the world
David J. Meltzer

PNAS August 26, 2014 111 (34) 12276-12277; first published August 13, 2014. https://doi.org/10.1073/pnas.1412945111
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Fungal polyketide engineering comes of age
Vinayak Agarwal and Bradley S. Moore

PNAS August 26, 2014 111 (34) 12278-12279; first published August 12, 2014. https://doi.org/10.1073/pnas.1412946111

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS August 26, 2014 111 (34) 12280-12281; https://doi.org/10.1073/pnas.ss11134

Vaccines PNAS 100th Anniversary Special Feature (Free Online)

Introduction
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  Vaccines: Science, health, longevity, and wealth
  From the Cover
  
  Rino Rappuoli
  
  PNAS August 26, 2014 111 (34) 12282; first published August 19, 2014. https://doi.org/10.1073/pnas.1413559111
Perspectives
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  History of vaccination
  Stanley Plotkin
  
  PNAS August 26, 2014 111 (34) 12283-12287; first published August 18, 2014. https://doi.org/10.1073/pnas.1400472111
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  Vaccines, new opportunities for a new society
  Rino Rappuoli, Mariagrazia Pizza, Giuseppe Del Giudice, and Ennio De Gregorio
  
  PNAS August 26, 2014 111 (34) 12288-12293; first published August 18, 2014. https://doi.org/10.1073/pnas.1402981111
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  Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants
  Charles Maisonneuve, Sylvie Bertholet, Dana J. Philpott, and Ennio De Gregorio
  
  PNAS August 26, 2014 111 (34) 12294-12299; first published August 18, 2014. https://doi.org/10.1073/pnas.1400478111
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  Systems vaccinology: Probing humanity’s diverse immune systems with vaccines
  Bali Pulendran
  
  PNAS August 26, 2014 111 (34) 12300-12306; first published August 18, 2014. https://doi.org/10.1073/pnas.1400476111
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  Vaccines against poverty
  Calman A. MacLennan and Allan Saul
  
  PNAS August 26, 2014 111 (34) 12307-12312; first published August 18, 2014. https://doi.org/10.1073/pnas.1400473111
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  Valuing vaccination
  Till Bärnighausen, David E. Bloom, Elizabeth T. Cafiero-Fonseca, and Jennifer Carroll O’Brien
  
  PNAS August 26, 2014 111 (34) 12313-12319; first published August 18, 2014. https://doi.org/10.1073/pnas.1400475111

Physical Sciences

Applied Physical Sciences
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  Single-shot stand-off chemical identification of powders using random Raman lasing
  From the Cover
  
  Brett H. Hokr, Joel N. Bixler, Gary D. Noojin, Robert J. Thomas, Benjamin A. Rockwell, Vladislav V. Yakovlev, and Marlan O. Scully
  
  PNAS August 26, 2014 111 (34) 12320-12324; first published August 11, 2014. https://doi.org/10.1073/pnas.1412535111
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  Collective credit allocation in science
  Hua-Wei Shen and Albert-László Barabási
  
  PNAS August 26, 2014 111 (34) 12325-12330; first published August 11, 2014. https://doi.org/10.1073/pnas.1401992111
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  A cellular solution to an information-processing problem
  Garud Iyengar and Madan Rao
  
  PNAS August 26, 2014 111 (34) 12402-12407; first published August 11, 2014. https://doi.org/10.1073/pnas.1406608111
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Quasi-resonant circulation regimes and hemispheric synchronization of extreme weather in boreal summer
  Dim Coumou, Vladimir Petoukhov, Stefan Rahmstorf, Stefan Petri, and Hans Joachim Schellnhuber
  
  PNAS August 26, 2014 111 (34) 12331-12336; first published August 11, 2014. https://doi.org/10.1073/pnas.1412797111
Environmental Sciences
- Open Access
  The Holocene temperature conundrum
  Zhengyu Liu, Jiang Zhu, Yair Rosenthal, Xu Zhang, Bette L. Otto-Bliesner, Axel Timmermann, Robin S. Smith, Gerrit Lohmann, Weipeng Zheng, and Oliver Elison Timm
  
  PNAS August 26, 2014 111 (34) E3501-E3505; first published August 11, 2014. https://doi.org/10.1073/pnas.1407229111
Physics
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  Fair sampling perspective on an apparent violation of duality
  Eliot Bolduc, Jonathan Leach, Filippo M. Miatto, Gerd Leuchs, and Robert W. Boyd
  
  PNAS August 26, 2014 111 (34) 12337-12341; first published August 11, 2014. https://doi.org/10.1073/pnas.1400106111
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  Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection
  Faruck Morcos, Nicholas P. Schafer, Ryan R. Cheng, José N. Onuchic, and Peter G. Wolynes
  
  PNAS August 26, 2014 111 (34) 12408-12413; first published August 11, 2014. https://doi.org/10.1073/pnas.1413575111

Biological Sciences

Anthropology
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  Drought stress variability in ancient Near Eastern agricultural systems evidenced by δ¹³C in barley grain
  Simone Riehl, Konstantin E. Pustovoytov, Heike Weippert, Stefan Klett, and Frank Hole
  
  PNAS August 26, 2014 111 (34) 12348-12353; first published August 11, 2014. https://doi.org/10.1073/pnas.1409516111
Applied Biological Sciences
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  Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases
  From the Cover
  
  Yuquan Xu, Tong Zhou, Shuwei Zhang, Patricia Espinosa-Artiles, Luoyi Wang, Wei Zhang, Min Lin, A. A. Leslie Gunatilaka, Jixun Zhan, and István Molnár
  
  PNAS August 26, 2014 111 (34) 12354-12359; first published July 21, 2014. https://doi.org/10.1073/pnas.1406999111
- Open Access
  Hybrid biosynthetic gene therapy vector development and dual engineering capacity
  Charles H. Jones, Anitha Ravikrishnan, Mingfu Chen, Ryan Reddinger, Mahmoud Kamal Ahmadi, Snehal Rane, Anders P. Hakansson, and Blaine A. Pfeifer
  
  PNAS August 26, 2014 111 (34) 12360-12365; first published August 11, 2014. https://doi.org/10.1073/pnas.1411355111
Biochemistry
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  A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface
  Linda Warfield, Lisa M. Tuttle, Derek Pacheco, Rachel E. Klevit, and Steven Hahn
  
  PNAS August 26, 2014 111 (34) E3506-E3513; first published August 13, 2014. https://doi.org/10.1073/pnas.1412088111
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  Mapping the λ Integrase bridges in the nucleoprotein Holliday junction intermediates of viral integrative and excisive recombination
  Wenjun Tong, David Warren, Nicole E. Seah, Gurunathan Laxmikanthan, Gregory D. Van Duyne, and Arthur Landy
  
  PNAS August 26, 2014 111 (34) 12366-12371; first published August 11, 2014. https://doi.org/10.1073/pnas.1413007111
- Open Access
  Nucleoprotein architectures regulating the directionality of viral integration and excision
  Nicole E. Seah, David Warren, Wenjun Tong, Gurunathan Laxmikanthan, Gregory D. Van Duyne, and Arthur Landy
  
  PNAS August 26, 2014 111 (34) 12372-12377; first published August 11, 2014. https://doi.org/10.1073/pnas.1413019111
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  EFA6 controls Arf1 and Arf6 activation through a negative feedback loop
  Dominique Padovani, Marcia Folly-Klan, Audrey Labarde, Sonia Boulakirba, Valérie Campanacci, Michel Franco, Mahel Zeghouf, and Jacqueline Cherfils
  
  PNAS August 26, 2014 111 (34) 12378-12383; first published August 11, 2014. https://doi.org/10.1073/pnas.1409832111
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  α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction
  Yi Jin, Debabrata Bhattasali, Erika Pellegrini, Stephanie M. Forget, Nicola J. Baxter, Matthew J. Cliff, Matthew W. Bowler, David L. Jakeman, G. Michael Blackburn, and Jonathan P. Waltho
  
  PNAS August 26, 2014 111 (34) 12384-12389; first published August 7, 2014. https://doi.org/10.1073/pnas.1402850111
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  Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking
  Jonathan E. Bird, Yasuharu Takagi, Neil Billington, Marie-Paule Strub, James R. Sellers, and Thomas B. Friedman
  
  PNAS August 26, 2014 111 (34) 12390-12395; first published August 11, 2014. https://doi.org/10.1073/pnas.1409459111
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  Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus
  André Schütte, Anna Ermund, Christoph Becker-Pauly, Malin E. V. Johansson, Ana M. Rodriguez-Pineiro, Fredrik Bäckhed, Stefan Müller, Daniel Lottaz, Judith S. Bond, and Gunnar C. Hansson
  
  PNAS August 26, 2014 111 (34) 12396-12401; first published August 11, 2014. https://doi.org/10.1073/pnas.1407597111
Biophysics and Computational Biology
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  Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5
  María Lucas, Andrew H. Gaspar, Chiara Pallara, Adriana Lucely Rojas, Juan Fernández-Recio, Matthias P. Machner, and Aitor Hierro
  
  PNAS August 26, 2014 111 (34) E3514-E3523; first published August 11, 2014. https://doi.org/10.1073/pnas.1405391111
- Open Access
  Electron spin changes during general anesthesia in Drosophila
  Luca Turin, Efthimios M. C. Skoulakis, and Andrew P. Horsfield
  
  PNAS August 26, 2014 111 (34) E3524-E3533; first published August 11, 2014. https://doi.org/10.1073/pnas.1404387111
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  A cellular solution to an information-processing problem
  Garud Iyengar and Madan Rao
  
  PNAS August 26, 2014 111 (34) 12402-12407; first published August 11, 2014. https://doi.org/10.1073/pnas.1406608111
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  Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection
  Faruck Morcos, Nicholas P. Schafer, Ryan R. Cheng, José N. Onuchic, and Peter G. Wolynes
  
  PNAS August 26, 2014 111 (34) 12408-12413; first published August 11, 2014. https://doi.org/10.1073/pnas.1413575111
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  Characterizing the proton loading site in cytochrome c oxidase
  Jianxun Lu and M. R. Gunner
  
  PNAS August 26, 2014 111 (34) 12414-12419; first published August 11, 2014. https://doi.org/10.1073/pnas.1407187111
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  Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms
  Pei-Hsuan Chu, Denis Tsygankov, Matthew E. Berginski, Onur Dagliyan, Shawn M. Gomez, Timothy C. Elston, Andrei V. Karginov, and Klaus M. Hahn
  
  PNAS August 26, 2014 111 (34) 12420-12425; first published August 12, 2014. https://doi.org/10.1073/pnas.1404487111
Cell Biology
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  Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma
  Frances E. Lock, Rita Rebollo, Katharine Miceli-Royer, Liane Gagnier, Sabrina Kuah, Artem Babaian, Maialen Sistiaga-Poveda, C. Benjamin Lai, Oksana Nemirovsky, Isabel Serrano, Christian Steidl, Mohammad M. Karimi, and Dixie L. Mager
  
  PNAS August 26, 2014 111 (34) E3534-E3543; first published August 11, 2014. https://doi.org/10.1073/pnas.1405507111
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  Calcineurin determines toxic versus beneficial responses to α-synuclein
  Gabriela Caraveo, Pavan K. Auluck, Luke Whitesell, Chee Yeun Chung, Valeriya Baru, Eugene V. Mosharov, Xiaohui Yan, Manu Ben-Johny, Martin Soste, Paola Picotti, Hanna Kim, Kim A. Caldwell, Guy A. Caldwell, David Sulzer, David T. Yue, and Susan Lindquist
  
  PNAS August 26, 2014 111 (34) E3544-E3552; first published August 13, 2014. https://doi.org/10.1073/pnas.1413201111
- Open Access
  Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential
  Mari Ohnuki, Koji Tanabe, Kenta Sutou, Ito Teramoto, Yuka Sawamura, Megumi Narita, Michiko Nakamura, Yumie Tokunaga, Masahiro Nakamura, Akira Watanabe, Shinya Yamanaka, and Kazutoshi Takahashi
  
  PNAS August 26, 2014 111 (34) 12426-12431; first published August 5, 2014. https://doi.org/10.1073/pnas.1413299111
- Open Access
  Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli
  Francis Impens, Lilliana Radoshevich, Pascale Cossart, and David Ribet
  
  PNAS August 26, 2014 111 (34) 12432-12437; first published August 11, 2014. https://doi.org/10.1073/pnas.1413825111
Developmental Biology
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  Primary cilia are required in a unique subpopulation of neural progenitors
  Cheuk Ka Tong, Young-Goo Han, Jugal K. Shah, Kirsten Obernier, Cristina D. Guinto, and Arturo Alvarez-Buylla
  
  PNAS August 26, 2014 111 (34) 12438-12443; first published August 11, 2014. https://doi.org/10.1073/pnas.1321425111
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  Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape
  Rachel S. Kadzik, Ethan David Cohen, Michael P. Morley, Kathleen M. Stewart, Min Min Lu, and Edward E. Morrisey
  
  PNAS August 26, 2014 111 (34) 12444-12449; first published August 11, 2014. https://doi.org/10.1073/pnas.1406639111
Genetics
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  Small RNA combination therapy for lung cancer
  Wen Xue, James E. Dahlman, Tuomas Tammela, Omar F. Khan, Sabina Sood, Apeksha Dave, Wenxin Cai, Leilani M. Chirino, Gillian R. Yang, Roderick Bronson, Denise G. Crowley, Gaurav Sahay, Avi Schroeder, Robert Langer, Daniel G. Anderson, and Tyler Jacks
  
  PNAS August 26, 2014 111 (34) E3553-E3561; first published August 11, 2014. https://doi.org/10.1073/pnas.1412686111
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  Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics
  Mauro Longoni, Frances A. High, Meaghan K. Russell, Alireza Kashani, Adam A. Tracy, Caroline M. Coletti, Regis Hila, Ahmed Shamia, Julie Wells, Kate G. Ackerman, Jay M. Wilson, Carol J. Bult, Charles Lee, Kasper Lage, Barbara R. Pober, and Patricia K. Donahoe
  
  PNAS August 26, 2014 111 (34) 12450-12455; first published August 8, 2014. https://doi.org/10.1073/pnas.1412509111
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  Predicting hybrid performance in rice using genomic best linear unbiased prediction
  Shizhong Xu, Dan Zhu, and Qifa Zhang
  
  PNAS August 26, 2014 111 (34) 12456-12461; first published August 11, 2014. https://doi.org/10.1073/pnas.1413750111
- Open Access
  Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics
  From the Cover
  
  Allen A. Cheng, Huiming Ding, and Timothy K. Lu
  
  PNAS August 26, 2014 111 (34) 12462-12467; first published August 11, 2014. https://doi.org/10.1073/pnas.1400093111
Immunology and Inflammation
- Open Access
  Murine CD27⁽⁻⁾ Vγ6⁽⁺⁾ γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages
  Margarida Rei, Natacha Gonçalves-Sousa, Telma Lança, Richard G. Thompson, Sofia Mensurado, Frances R. Balkwill, Hagen Kulbe, Daniel J. Pennington, and Bruno Silva-Santos
  
  PNAS August 26, 2014 111 (34) E3562-E3570; first published August 11, 2014. https://doi.org/10.1073/pnas.1403424111
- Open Access
  Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells
  Thomas B. Sundberg, Hwan Geun Choi, Joo-Hye Song, Caitlin N. Russell, Mahmud M. Hussain, Daniel B. Graham, Bernard Khor, John Gagnon, Daniel J. O’Connell, Kavitha Narayan, Vlado Dančík, Jose R. Perez, Hans-Christian Reinecker, Nathanael S. Gray, Stuart L. Schreiber, Ramnik J. Xavier, and Alykhan F. Shamji
  
  PNAS August 26, 2014 111 (34) 12468-12473; first published August 11, 2014. https://doi.org/10.1073/pnas.1412308111
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  KLRG⁺ invariant natural killer T cells are long-lived effectors
  Kanako Shimizu, Yusuke Sato, Jun Shinga, Takashi Watanabe, Takaho Endo, Miki Asakura, Satoru Yamasaki, Kazuyoshi Kawahara, Yuki Kinjo, Hiroshi Kitamura, Hiroshi Watarai, Yasuyuki Ishii, Moriya Tsuji, Masaru Taniguchi, Osamu Ohara, and Shin-ichiro Fujii
  
  PNAS August 26, 2014 111 (34) 12474-12479; first published August 12, 2014. https://doi.org/10.1073/pnas.1406240111
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  Autophagy protects C. elegans against necrosis during Pseudomonas aeruginosa infection
  Cheng-Gang Zou, Yi-Cheng Ma, Li-Li Dai, and Ke-Qin Zhang
  
  PNAS August 26, 2014 111 (34) 12480-12485; first published August 11, 2014. https://doi.org/10.1073/pnas.1405032111
Medical Sciences
- Open Access
  Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia–cell cycle dual reporter
  Anne Le, Zachary E. Stine, Christopher Nguyen, Junaid Afzal, Peng Sun, Max Hamaker, Nicholas M. Siegel, Arvin M. Gouw, Byung-hak Kang, Shu-Han Yu, Rory L. Cochran, Kurt A. Sailor, Hongjun Song, and Chi V. Dang
  
  PNAS August 26, 2014 111 (34) 12486-12491; first published August 11, 2014. https://doi.org/10.1073/pnas.1402012111
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  Interleukin-1 deficiency prolongs ovarian lifespan in mice
  Shiri Uri-Belapolsky, Aviv Shaish, Efrat Eliyahu, Hadas Grossman, Mattan Levi, Dana Chuderland, Lihi Ninio-Many, Noa Hasky, David Shashar, Tal Almog, Michal Kandel-Kfir, Dror Harats, Ruth Shalgi, and Yehuda Kamari
  
  PNAS August 26, 2014 111 (34) 12492-12497; first published August 11, 2014. https://doi.org/10.1073/pnas.1323955111
Microbiology
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  Native microbiome impedes vertical transmission of Wolbachia in Anopheles mosquitoes
  Grant L. Hughes, Brittany L. Dodson, Rebecca M. Johnson, Courtney C. Murdock, Hitoshi Tsujimoto, Yasutsugu Suzuki, Alyssa A. Patt, Long Cui, Carlos W. Nossa, Rhiannon M. Barry, Joyce M. Sakamoto, Emily A. Hornett, and Jason L. Rasgon
  
  PNAS August 26, 2014 111 (34) 12498-12503; first published August 11, 2014. https://doi.org/10.1073/pnas.1408888111
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  Marine ammonia-oxidizing archaeal isolates display obligate mixotrophy and wide ecotypic variation
  Wei Qin, Shady A. Amin, Willm Martens-Habbena, Christopher B. Walker, Hidetoshi Urakawa, Allan H. Devol, Anitra E. Ingalls, James W. Moffett, E. Virginia Armbrust, and David A. Stahl
  
  PNAS August 26, 2014 111 (34) 12504-12509; first published August 11, 2014. https://doi.org/10.1073/pnas.1324115111
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  Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids
  John P. Santa Maria Jr., Ama Sadaka, Samir H. Moussa, Stephanie Brown, Yanjia J. Zhang, Eric J. Rubin, Michael S. Gilmore, and Suzanne Walker
  
  PNAS August 26, 2014 111 (34) 12510-12515; first published August 7, 2014. https://doi.org/10.1073/pnas.1404099111
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  Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus
  Yang Yang, Lanying Du, Chang Liu, Lili Wang, Cuiqing Ma, Jian Tang, Ralph S. Baric, Shibo Jiang, and Fang Li
  
  PNAS August 26, 2014 111 (34) 12516-12521; first published August 11, 2014. https://doi.org/10.1073/pnas.1405889111
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  Patterned progression of bacterial populations in the premature infant gut
  Patricio S. La Rosa, Barbara B. Warner, Yanjiao Zhou, George M. Weinstock, Erica Sodergren, Carla M. Hall-Moore, Harold J. Stevens, William E. Bennett Jr., Nurmohammad Shaikh, Laura A. Linneman, Julie A. Hoffmann, Aaron Hamvas, Elena Deych, Berkley A. Shands, William D. Shannon, and Phillip I. Tarr
  
  PNAS August 26, 2014 111 (34) 12522-12527; first published August 11, 2014. https://doi.org/10.1073/pnas.1409497111
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  Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice
  Cailin Deal, Alejandro B. Balazs, Diego A. Espinosa, Fidel Zavala, David Baltimore, and Gary Ketner
  
  PNAS August 26, 2014 111 (34) 12528-12532; first published August 11, 2014. https://doi.org/10.1073/pnas.1407362111
Neuroscience
- Open Access
  Socially responsive effects of brain oxidative metabolism on aggression
  Hongmei Li-Byarlay, Clare C. Rittschof, Jonathan H. Massey, Barry R. Pittendrigh, and Gene E. Robinson
  
  PNAS August 26, 2014 111 (34) 12533-12537; first published August 4, 2014. https://doi.org/10.1073/pnas.1412306111
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  Nicotinic and muscarinic agonists and acetylcholinesterase inhibitors stimulate a common pathway to enhance GluN2B-NMDAR responses
  Masaru Ishibashi, Yoshihiko Yamazaki, Ricardo Miledi, and Katumi Sumikawa
  
  PNAS August 26, 2014 111 (34) 12538-12543; first published August 11, 2014. https://doi.org/10.1073/pnas.1408805111
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  DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris
  Tsai-Yi Lu, Johnna Doherty, and Marc R. Freeman
  
  PNAS August 26, 2014 111 (34) 12544-12549; first published August 6, 2014. https://doi.org/10.1073/pnas.1403450111
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  MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma
  Brian J. Gill, David J. Pisapia, Hani R. Malone, Hannah Goldstein, Liang Lei, Adam Sonabend, Jonathan Yun, Jorge Samanamud, Jennifer S. Sims, Matei Banu, Athanassios Dovas, Andrew F. Teich, Sameer A. Sheth, Guy M. McKhann, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, and Peter Canoll
  
  PNAS August 26, 2014 111 (34) 12550-12555; first published August 11, 2014. https://doi.org/10.1073/pnas.1405839111
Pharmacology
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  Inhibitor of MYC identified in a Kröhnke pyridine library
  Jonathan R. Hart, Amanda L. Garner, Jing Yu, Yoshihiro Ito, Minghao Sun, Lynn Ueno, Jin-Kyu Rhee, Michael M. Baksh, Eduard Stefan, Markus Hartl, Klaus Bister, Peter K. Vogt, and Kim D. Janda
  
  PNAS August 26, 2014 111 (34) 12556-12561; first published August 11, 2014. https://doi.org/10.1073/pnas.1319488111
Physiology
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  Genetic–epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity
  Mihaela Stefan, Chengguo Wei, Angela Lombardi, Cheuk Wun Li, Erlinda S. Concepcion, William B. Inabnet III, Randall Owen, Weijia Zhang, and Yaron Tomer
  
  PNAS August 26, 2014 111 (34) 12562-12567; first published August 13, 2014. https://doi.org/10.1073/pnas.1408821111
Plant Biology
- Open Access
  DELAY OF GERMINATION 1 mediates a conserved coat-dormancy mechanism for the temperature- and gibberellin-dependent control of seed germination
  Kai Graeber, Ada Linkies, Tina Steinbrecher, Klaus Mummenhoff, Danuše Tarkowská, Veronika Turečková, Michael Ignatz, Katja Sperber, Antje Voegele, Hans de Jong, Terezie Urbanová, Miroslav Strnad, and Gerhard Leubner-Metzger
  
  PNAS August 26, 2014 111 (34) E3571-E3580; first published August 11, 2014. https://doi.org/10.1073/pnas.1403851111

Correction

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Correction for Poulson-Ellestad et al., Metabolomics and proteomics reveal impacts of chemically mediated competition on marine plankton
PNAS August 26, 2014 111 (34) 12568; first published August 11, 2014. https://doi.org/10.1073/pnas.1413432111

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This Week in PNAS

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This Week in PNAS

Letters (Online Only)

Inner Workings

Commentaries

PNAS Plus Significance Statements

Vaccines PNAS 100th Anniversary Special Feature (Free Online)

Introduction

Perspectives

Physical Sciences

Applied Physical Sciences

Earth, Atmospheric, and Planetary Sciences

Environmental Sciences

Physics

Social Sciences

Anthropology

Sustainability Science

Biological Sciences

Anthropology

Applied Biological Sciences

Biochemistry

Biophysics and Computational Biology

Cell Biology

Developmental Biology

Genetics

Immunology and Inflammation

Medical Sciences

Microbiology

Neuroscience

Pharmacology

Physiology

Plant Biology

Correction

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