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Research Article

Robustness against serum neutralization of a poliovirus type 1 from a lethal epidemic of poliomyelitis in the Republic of Congo in 2010

Jan Felix Drexler, Gilda Grard, Alexander N. Lukashev, Liubov I. Kozlovskaya, Sindy Böttcher, Gökhan Uslu, Johan Reimerink, Anatoly P. Gmyl, Raphaël Taty-Taty, Sonia Etenna Lekana-Douki, Dieudonné Nkoghe, Anna M. Eis-Hübinger, Sabine Diedrich, Marion Koopmans, Eric M. Leroy, and Christian Drosten
  1. aInstitute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany;
  2. bCentre International de Recherches Médicales de Franceville, BP 769 Franceville, Gabon;
  3. cChumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow 142782, Russia;
  4. dRobert Koch Institute, National Reference Laboratory for Poliomyelitis and Enteroviruses, 13302 Berlin, Germany;
  5. eNetherlands Center for Infectious Disease Control, 3720, Bilthoven, The Netherlands;
  6. fLomonosov Moscow State University, Moscow 119991, Russia;
  7. gMinistry of Health, Pointe Noire, Republic of Congo; and
  8. hInstitut de Recherche pour le Développement, Unité Mixte de Recherche 224 (Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle), Institut de Recherche pour le Développement/Centre National de la Recherche Scientifique/Unité Mixte 1, 34032 Montpellier, France

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PNAS September 2, 2014 111 (35) 12889-12894; first published August 18, 2014; https://doi.org/10.1073/pnas.1323502111
Jan Felix Drexler
aInstitute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany;
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Gilda Grard
bCentre International de Recherches Médicales de Franceville, BP 769 Franceville, Gabon;
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Alexander N. Lukashev
cChumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow 142782, Russia;
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Liubov I. Kozlovskaya
cChumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow 142782, Russia;
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Sindy Böttcher
dRobert Koch Institute, National Reference Laboratory for Poliomyelitis and Enteroviruses, 13302 Berlin, Germany;
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Gökhan Uslu
eNetherlands Center for Infectious Disease Control, 3720, Bilthoven, The Netherlands;
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Johan Reimerink
eNetherlands Center for Infectious Disease Control, 3720, Bilthoven, The Netherlands;
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Anatoly P. Gmyl
cChumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow 142782, Russia;
fLomonosov Moscow State University, Moscow 119991, Russia;
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Raphaël Taty-Taty
gMinistry of Health, Pointe Noire, Republic of Congo; and
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Sonia Etenna Lekana-Douki
bCentre International de Recherches Médicales de Franceville, BP 769 Franceville, Gabon;
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Dieudonné Nkoghe
bCentre International de Recherches Médicales de Franceville, BP 769 Franceville, Gabon;
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Anna M. Eis-Hübinger
aInstitute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany;
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Sabine Diedrich
dRobert Koch Institute, National Reference Laboratory for Poliomyelitis and Enteroviruses, 13302 Berlin, Germany;
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Marion Koopmans
eNetherlands Center for Infectious Disease Control, 3720, Bilthoven, The Netherlands;
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Eric M. Leroy
bCentre International de Recherches Médicales de Franceville, BP 769 Franceville, Gabon;
hInstitut de Recherche pour le Développement, Unité Mixte de Recherche 224 (Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle), Institut de Recherche pour le Développement/Centre National de la Recherche Scientifique/Unité Mixte 1, 34032 Montpellier, France
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  • For correspondence: drosten@virology-bonn.de eric.leroy@ird.fr
Christian Drosten
aInstitute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany;
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  • For correspondence: drosten@virology-bonn.de eric.leroy@ird.fr
  1. Edited by Eckard Wimmer, Stony Brook University, Stony Brook, NY, and approved July 23, 2014 (received for review December 17, 2013)

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Article Information

vol. 111 no. 35 12889-12894
DOI: 
https://doi.org/10.1073/pnas.1323502111
PubMed: 
25136105

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue September 2, 2014.
  • Published first August 18, 2014.

Article Versions

  • Previous version (August 18, 2014 - 12:12).
  • You are viewing the most recent version of this article.

Author Information

  1. Jan Felix Drexlera,1,
  2. Gilda Grardb,1,
  3. Alexander N. Lukashevc,
  4. Liubov I. Kozlovskayac,
  5. Sindy Böttcherd,
  6. Gökhan Uslue,
  7. Johan Reimerinke,
  8. Anatoly P. Gmylc,f,
  9. Raphaël Taty-Tatyg,
  10. Sonia Etenna Lekana-Doukib,
  11. Dieudonné Nkogheb,
  12. Anna M. Eis-Hübingera,
  13. Sabine Diedrichd,
  14. Marion Koopmanse,
  15. Eric M. Leroyb,h,1,2, and
  16. Christian Drostena,1,2
  1. aInstitute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany;
  2. bCentre International de Recherches Médicales de Franceville, BP 769 Franceville, Gabon;
  3. cChumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow 142782, Russia;
  4. dRobert Koch Institute, National Reference Laboratory for Poliomyelitis and Enteroviruses, 13302 Berlin, Germany;
  5. eNetherlands Center for Infectious Disease Control, 3720, Bilthoven, The Netherlands;
  6. fLomonosov Moscow State University, Moscow 119991, Russia;
  7. gMinistry of Health, Pointe Noire, Republic of Congo; and
  8. hInstitut de Recherche pour le Développement, Unité Mixte de Recherche 224 (Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle), Institut de Recherche pour le Développement/Centre National de la Recherche Scientifique/Unité Mixte 1, 34032 Montpellier, France
  1. Edited by Eckard Wimmer, Stony Brook University, Stony Brook, NY, and approved July 23, 2014 (received for review December 17, 2013)

Footnotes

  • ↵1J.F.D., G.G., E.M.L., and C.D. contributed equally to this work.

  • ↵2To whom correspondence may be addressed. Email: drosten{at}virology-bonn.de or eric.leroy{at}ird.fr.
  • Author contributions: J.F.D., E.M.L., and C.D. designed research; J.F.D., G.G., A.N.L., L.I.K., S.B., G.U., J.R., S.E.L.-D., and S.D. performed research; G.G., A.P.G., R.T.-T., D.N., and M.K. contributed new reagents/analytic tools; J.F.D., A.N.L., A.M.E.-H., S.D., M.K., E.M.L., and C.D. analyzed data; and J.F.D., E.M.L., and C.D. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • Data deposition: The nucleotide sequences reported in this paper have been deposited in the GenBank database (accession nos. JF838278–JF838290).

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1323502111/-/DCSupplemental.

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Poliovirus drift variant
Jan Felix Drexler, Gilda Grard, Alexander N. Lukashev, Liubov I. Kozlovskaya, Sindy Böttcher, Gökhan Uslu, Johan Reimerink, Anatoly P. Gmyl, Raphaël Taty-Taty, Sonia Etenna Lekana-Douki, Dieudonné Nkoghe, Anna M. Eis-Hübinger, Sabine Diedrich, Marion Koopmans, Eric M. Leroy, Christian Drosten
Proceedings of the National Academy of Sciences Sep 2014, 111 (35) 12889-12894; DOI: 10.1073/pnas.1323502111

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Poliovirus drift variant
Jan Felix Drexler, Gilda Grard, Alexander N. Lukashev, Liubov I. Kozlovskaya, Sindy Böttcher, Gökhan Uslu, Johan Reimerink, Anatoly P. Gmyl, Raphaël Taty-Taty, Sonia Etenna Lekana-Douki, Dieudonné Nkoghe, Anna M. Eis-Hübinger, Sabine Diedrich, Marion Koopmans, Eric M. Leroy, Christian Drosten
Proceedings of the National Academy of Sciences Sep 2014, 111 (35) 12889-12894; DOI: 10.1073/pnas.1323502111
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