Table of Contents

Biological Sciences

• Agricultural Sciences

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    Genetic erosion in maize’s center of origin

    • From the Cover

    George A. Dyer, Alejandro López-Feldman, Antonio Yúnez-Naude, and J. Edward Taylor

    PNAS September 30, 2014 111 (39) 14094-14099; first published September 2, 2014. https://doi.org/10.1073/pnas.1407033111

    See companion article:

    • Wake-up call for crop conservation science

      - Dec 29, 2014

• Anthropology

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    Ethnolinguistic structuring of sorghum genetic diversity in Africa and the role of local seed systems

    Ola T. Westengen, Mark Atam Okongo, Leo Onek, Trygve Berg, Hari Upadhyaya, Siri Birkeland, Siri Dharma Kaur Khalsa, Kristoffer H. Ring, Nils C. Stenseth, and Anne K. Brysting

    PNAS September 30, 2014 111 (39) 14100-14105; first published September 15, 2014. https://doi.org/10.1073/pnas.1401646111

• Applied Biological Sciences

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    Bioreplicated visual features of nanofabricated buprestid beetle decoys evoke stereotypical male mating flights

    Michael J. Domingue, Akhlesh Lakhtakia, Drew P. Pulsifer, Loyal P. Hall, John V. Badding, Jesse L. Bischof, Raúl J. Martín-Palma, Zoltán Imrei, Gergely Janik, Victor C. Mastro, Missy Hazen, and Thomas C. Baker

    PNAS September 30, 2014 111 (39) 14106-14111; first published September 15, 2014. https://doi.org/10.1073/pnas.1412810111

• Biochemistry

  • Open Access

    Immature truncated O-glycophenotype of cancer directly induces oncogenic features

    Prakash Radhakrishnan, Sally Dabelsteen, Frey Brus Madsen, Chiara Francavilla, Katharina L. Kopp, Catharina Steentoft, Sergey Y. Vakhrushev, Jesper V. Olsen, Lars Hansen, Eric P. Bennett, Anders Woetmann, Guangliang Yin, Longyun Chen, Haiyan Song, Mads Bak, Ryan A. Hlady, Staci L. Peters, Rene Opavsky, Christenze Thode, Klaus Qvortrup, Katrine T.-B. G. Schjoldager, Henrik Clausen, Michael A. Hollingsworth, and Hans H. Wandall

    PNAS September 30, 2014 111 (39) E4066-E4075; first published August 12, 2014. https://doi.org/10.1073/pnas.1406619111

    See companion article:

    • Not so sweet malignant transformation

      - Sep 16, 2014
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    Mu transpososome and RecBCD nuclease collaborate in the repair of simple Mu insertions

    Wonyoung Choi, Sooin Jang, and Rasika M. Harshey

    PNAS September 30, 2014 111 (39) 14112-14117; first published September 2, 2014. https://doi.org/10.1073/pnas.1407562111
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    Sequential switching of binding partners on PCNA during in vitro Okazaki fragment maturation

    Daniel Dovrat, Joseph L. Stodola, Peter M. J. Burgers, and Amir Aharoni

    PNAS September 30, 2014 111 (39) 14118-14123; first published September 16, 2014. https://doi.org/10.1073/pnas.1321349111
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    Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation

    Christoph F. Kurat, Jean-Philippe Lambert, Julia Petschnigg, Helena Friesen, Tony Pawson, Adam Rosebrock, Anne-Claude Gingras, Jeffrey Fillingham, and Brenda Andrews

    PNAS September 30, 2014 111 (39) 14124-14129; first published September 16, 2014. https://doi.org/10.1073/pnas.1414024111

• Biophysics and Computational Biology

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    Landscape and flux reveal a new global view and physical quantification of mammalian cell cycle

    Chunhe Li and Jin Wang

    PNAS September 30, 2014 111 (39) 14130-14135; first published September 16, 2014. https://doi.org/10.1073/pnas.1408628111
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    Kinesin processivity is gated by phosphate release

    Bojan Milic, Johan O. L. Andreasson, William O. Hancock, and Steven M. Block

    PNAS September 30, 2014 111 (39) 14136-14140; first published September 2, 2014. https://doi.org/10.1073/pnas.1410943111
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    Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

    Stefano Gianni, Carlo Camilloni, Rajanish Giri, Angelo Toto, Daniela Bonetti, Angela Morrone, Pietro Sormanni, Maurizio Brunori, and Michele Vendruscolo

    PNAS September 30, 2014 111 (39) 14141-14146; first published September 16, 2014. https://doi.org/10.1073/pnas.1405233111

• Cell Biology

  • Open Access

    Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

    Dana Westphal, Grant Dewson, Marie Menard, Paul Frederick, Sweta Iyer, Ray Bartolo, Leonie Gibson, Peter E. Czabotar, Brian J. Smith, Jerry M. Adams, and Ruth M. Kluck

    PNAS September 30, 2014 111 (39) E4076-E4085; first published September 16, 2014. https://doi.org/10.1073/pnas.1415142111
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    Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions

    • Inaugural Article

    Nathaniel H. Thayer, Christina K. Leverich, Matthew P. Fitzgibbon, Zara W. Nelson, Kiersten A. Henderson, Philip R. Gafken, Jessica J. Hsu, and Daniel E. Gottschling

    PNAS September 30, 2014 111 (39) 14019-14026; first published September 16, 2014. https://doi.org/10.1073/pnas.1416079111

    See companion article:

    • Profile of Daniel E. Gottschling

      - Sep 22, 2014
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    Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

    • From the Cover

    Chun A. Changou, Yun-Ru Chen, Li Xing, Yun Yen, Frank Y. S. Chuang, R. Holland Cheng, Richard J. Bold, David K. Ann, and Hsing-Jien Kung

    PNAS September 30, 2014 111 (39) 14147-14152; first published August 13, 2014. https://doi.org/10.1073/pnas.1404171111

    See companion article:

    • Arginine and autophagic cell death in cancer

      - Sep 16, 2014

• Developmental Biology

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    Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development

    Darshan Sapkota, Hemabindu Chintala, Fuguo Wu, Steven J. Fliesler, Zihua Hu, and Xiuqian Mu

    PNAS September 30, 2014 111 (39) E4086-E4095; first published September 16, 2014. https://doi.org/10.1073/pnas.1405354111

• Ecology

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    Phylogenetic analysis of beak and feather disease virus across a host ring-species complex

    Justin R. Eastwood, Mathew L. Berg, Raoul F. H. Ribot, Shane R. Raidal, Katherine L. Buchanan, Ken R. Walder, and Andrew T. D. Bennett

    PNAS September 30, 2014 111 (39) 14153-14158; first published September 15, 2014. https://doi.org/10.1073/pnas.1403255111

• Evolution

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    Ecological and evolutionary significance of genomic GC content diversity in monocots

    Petr Šmarda, Petr Bureš, Lucie Horová, Ilia J. Leitch, Ladislav Mucina, Ettore Pacini, Lubomír Tichý, Vít Grulich, and Olga Rotreklová

    PNAS September 30, 2014 111 (39) E4096-E4102; first published September 15, 2014. https://doi.org/10.1073/pnas.1321152111
  • Open Access

    Evolution of Drosophila sex comb length illustrates the inextricable interplay between selection and variation

    Juan N. Malagón, Abha Ahuja, Gabilan Sivapatham, Julian Hung, Jiwon Lee, Sergio A. Muñoz-Gómez, Joel Atallah, Rama S. Singh, and Ellen Larsen

    PNAS September 30, 2014 111 (39) E4103-E4109; first published September 2, 2014. https://doi.org/10.1073/pnas.1322342111

    See companion article:

    • Constraint and selection on sex combs

      - Sep 16, 2014
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    Both endo-siRNAs and tRNA-derived small RNAs are involved in the differentiation of primitive eukaryote Giardia lamblia

    Jian-You Liao, Yan-Hua Guo, Ling-Ling Zheng, Yan Li, Wen-Li Xu, Yu-Chan Zhang, Hui Zhou, Zhao-Rong Lun, Francisco J. Ayala, and Liang-Hu Qu

    PNAS September 30, 2014 111 (39) 14159-14164; first published September 15, 2014. https://doi.org/10.1073/pnas.1414394111
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    Natural selection on thermal performance in a novel thermal environment

    Michael L. Logan, Robert M. Cox, and Ryan Calsbeek

    PNAS September 30, 2014 111 (39) 14165-14169; first published September 15, 2014. https://doi.org/10.1073/pnas.1404885111
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    Early origin of parental care in Mesozoic carrion beetles

    Chen-Yang Cai, Margaret K. Thayer, Michael S. Engel, Alfred F. Newton, Jaime Ortega-Blanco, Bo Wang, Xiang-Dong Wang, and Di-Ying Huang

    PNAS September 30, 2014 111 (39) 14170-14174; first published September 15, 2014. https://doi.org/10.1073/pnas.1412280111

• Genetics

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    Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria

    Gloria Arriagada, Michael J. Metzger, Annette F. Muttray, James Sherry, Carol Reinisch, Craig Street, W. Ian Lipkin, and Stephen P. Goff

    PNAS September 30, 2014 111 (39) 14175-14180; first published September 8, 2014. https://doi.org/10.1073/pnas.1409945111
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    JIP60-mediated, jasmonate- and senescence-induced molecular switch in translation toward stress and defense protein synthesis

    Sachin Rustgi, Stephan Pollmann, Frank Buhr, Armin Springer, Christiane Reinbothe, Diter von Wettstein, and Steffen Reinbothe

    PNAS September 30, 2014 111 (39) 14181-14186; first published September 15, 2014. https://doi.org/10.1073/pnas.1415690111
  • Open Access

    Silencing of a metaphase I-specific gene results in a phenotype similar to that of the Pairing homeologous 1 (Ph1) gene mutations

    Ramanjot Bhullar, Ragupathi Nagarajan, Harvinder Bennypaul, Gaganpreet K. Sidhu, Gaganjot Sidhu, Sachin Rustgi, Diter von Wettstein, and Kulvinder S. Gill

    PNAS September 30, 2014 111 (39) 14187-14192; first published September 17, 2014. https://doi.org/10.1073/pnas.1416241111

• Immunology and Inflammation

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    Hemolysis-induced lethality involves inflammasome activation by heme

    Fabianno F. Dutra, Letícia S. Alves, Danielle Rodrigues, Patricia L. Fernandez, Rosane B. de Oliveira, Douglas T. Golenbock, Dario S. Zamboni, and Marcelo T. Bozza

    PNAS September 30, 2014 111 (39) E4110-E4118; first published September 15, 2014. https://doi.org/10.1073/pnas.1405023111
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    B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS

    Gabriel K. Pedersen, Monika Àdori, Sharesta Khoenkhoen, Pia Dosenovic, Bruce Beutler, and Gunilla B. Karlsson Hedestam

    PNAS September 30, 2014 111 (39) E4119-E4126; first published September 16, 2014. https://doi.org/10.1073/pnas.1415866111
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    Mathematical model of renal interstitial fibrosis

    Wenrui Hao, Brad H. Rovin, and Avner Friedman

    PNAS September 30, 2014 111 (39) 14193-14198; first published September 15, 2014. https://doi.org/10.1073/pnas.1413970111
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    Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication

    Zhenhong Guo, Tamara Tilburgs, Bonnie Wong, and Jack L. Strominger

    PNAS September 30, 2014 111 (39) 14199-14204; first published September 15, 2014. https://doi.org/10.1073/pnas.1414780111

• Medical Sciences

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    Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2

    • From the Cover

    Efrat Gabai-Kapara, Amnon Lahad, Bella Kaufman, Eitan Friedman, Shlomo Segev, Paul Renbaum, Rachel Beeri, Moran Gal, Julia Grinshpun-Cohen, Karen Djemal, Jessica B. Mandell, Ming K. Lee, Uziel Beller, Raphael Catane, Mary-Claire King, and Ephrat Levy-Lahad

    PNAS September 30, 2014 111 (39) 14205-14210; first published September 5, 2014. https://doi.org/10.1073/pnas.1415979111
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    Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

    Heinz Läubli, Oliver M. T. Pearce, Flavio Schwarz, Shoib S. Siddiqui, Lingquan Deng, Michal A. Stanczak, Liwen Deng, Andrea Verhagen, Patrick Secrest, Chrissy Lusk, Ann G. Schwartz, Nissi M. Varki, Jack D. Bui, and Ajit Varki

    PNAS September 30, 2014 111 (39) 14211-14216; first published September 15, 2014. https://doi.org/10.1073/pnas.1409580111
  • Open Access

    Hominoid-specific enzyme GLUD2 promotes growth of IDH1^R132H glioma

    Ruihuan Chen, Merry C. Nishimura, Samir Kharbanda, Frank Peale, Yuzhong Deng, Anneleen Daemen, William F. Forrest, Mandy Kwong, Maj Hedehus, Georgia Hatzivassiliou, Lori S. Friedman, and Heidi S. Phillips

    PNAS September 30, 2014 111 (39) 14217-14222; first published September 15, 2014. https://doi.org/10.1073/pnas.1409653111

• Microbiology

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    Pulque production from fermented agave sap as a dietary supplement in Prehispanic Mesoamerica

    Marisol Correa-Ascencio, Ian G. Robertson, Oralia Cabrera-Cortés, Rubén Cabrera-Castro, and Richard P. Evershed

    PNAS September 30, 2014 111 (39) 14223-14228; first published September 15, 2014. https://doi.org/10.1073/pnas.1408339111
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    Cell cycle-dependent adaptor complex for ClpXP-mediated proteolysis directly integrates phosphorylation and second messenger signals

    Stephen C. Smith, Kamal K. Joshi, Justin J. Zik, Katherine Trinh, Aron Kamajaya, Peter Chien, and Kathleen R. Ryan

    PNAS September 30, 2014 111 (39) 14229-14234; first published September 2, 2014. https://doi.org/10.1073/pnas.1407862111
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    LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2

    João C. Marques, Il Kyu Oh, Daniel C. Ly, Pedro Lamosa, M. Rita Ventura, Stephen T. Miller, and Karina B. Xavier

    PNAS September 30, 2014 111 (39) 14235-14240; first published September 15, 2014. https://doi.org/10.1073/pnas.1408691111
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    RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae

    Gregor G. Weber, Jens Kortmann, Franz Narberhaus, and Karl E. Klose

    PNAS September 30, 2014 111 (39) 14241-14246; first published September 16, 2014. https://doi.org/10.1073/pnas.1411570111

• Neuroscience

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    Network measures predict neuropsychological outcome after brain injury

    David E. Warren, Jonathan D. Power, Joel Bruss, Natalie L. Denburg, Eric J. Waldron, Haoxin Sun, Steven E. Petersen, and Daniel Tranel

    PNAS September 30, 2014 111 (39) 14247-14252; first published September 15, 2014. https://doi.org/10.1073/pnas.1322173111
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    Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance

    Christiane Schreiweis, Ulrich Bornschein, Eric Burguière, Cemil Kerimoglu, Sven Schreiter, Michael Dannemann, Shubhi Goyal, Ellis Rea, Catherine A. French, Rathi Puliyadi, Matthias Groszer, Simon E. Fisher, Roger Mundry, Christine Winter, Wulf Hevers, Svante Pääbo, Wolfgang Enard, and Ann M. Graybiel

    PNAS September 30, 2014 111 (39) 14253-14258; first published September 15, 2014. https://doi.org/10.1073/pnas.1414542111
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    Lag in maturation of the brain’s intrinsic functional architecture in attention-deficit/hyperactivity disorder

    Chandra S. Sripada, Daniel Kessler, and Mike Angstadt

    PNAS September 30, 2014 111 (39) 14259-14264; first published September 15, 2014. https://doi.org/10.1073/pnas.1407787111
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    Ultradian corticosterone pulses balance glutamatergic transmission and synaptic plasticity

    Ratna Angela Sarabdjitsingh, Julie Jezequel, Natasha Pasricha, Lenka Mikasova, Amber Kerkhofs, Henk Karst, Laurent Groc, and Marian Joëls

    PNAS September 30, 2014 111 (39) 14265-14270; first published September 15, 2014. https://doi.org/10.1073/pnas.1411216111
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    Selective filtering defect at the axon initial segment in Alzheimer’s disease mouse models

    Xiaqin Sun, Yu Wu, Mingxue Gu, Zhuo Liu, Yuanlin Ma, Jun Li, and Yan Zhang

    PNAS September 30, 2014 111 (39) 14271-14276; first published September 17, 2014. https://doi.org/10.1073/pnas.1411837111
  • Open Access

    A common neural code for similar conscious experiences in different individuals

    Lorina Naci, Rhodri Cusack, Mimma Anello, and Adrian M. Owen

    PNAS September 30, 2014 111 (39) 14277-14282; first published September 15, 2014. https://doi.org/10.1073/pnas.1407007111

• Physiology

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    Cyst formation following disruption of intracellular calcium signaling

    Ivana Y. Kuo, Teresa M. DesRochers, Erica P. Kimmerling, Lily Nguyen, Barbara E. Ehrlich, and David L. Kaplan

    PNAS September 30, 2014 111 (39) 14283-14288; first published September 16, 2014. https://doi.org/10.1073/pnas.1412323111
  • Open Access

    Role of forkhead box protein A3 in age-associated metabolic decline

    Xinran Ma, Lingyan Xu, Oksana Gavrilova, and Elisabetta Mueller

    PNAS September 30, 2014 111 (39) 14289-14294; first published September 15, 2014. https://doi.org/10.1073/pnas.1407640111
  • Open Access

    Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice

    Yan Liu, Brian P. Johnson, Anna L. Shen, Jacqueline A. Wallisser, Kathy J. Krentz, Susan M. Moran, Ruth Sullivan, Edward Glover, Albert F. Parlow, Norman R. Drinkwater, Linda A. Schuler, and Christopher A. Bradfield

    PNAS September 30, 2014 111 (39) 14295-14300; first published September 15, 2014. https://doi.org/10.1073/pnas.1209249111
  • Open Access

    Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis

    Pablo Cabrero, Selim Terhzaz, Michael F. Romero, Shireen A. Davies, Edward M. Blumenthal, and Julian A. T. Dow

    PNAS September 30, 2014 111 (39) 14301-14306; first published September 16, 2014. https://doi.org/10.1073/pnas.1412706111

• Systems Biology

  • Open Access

    Multiscale digital Arabidopsis predicts individual organ and whole-organism growth

    Yin Hoon Chew, Bénédicte Wenden, Anna Flis, Virginie Mengin, Jasper Taylor, Christopher L. Davey, Christopher Tindal, Howard Thomas, Helen J. Ougham, Philippe de Reffye, Mark Stitt, Mathew Williams, Robert Muetzelfeldt, Karen J. Halliday, and Andrew J. Millar

    PNAS September 30, 2014 111 (39) E4127-E4136; first published September 2, 2014. https://doi.org/10.1073/pnas.1410238111