Proceedings of the National Academy of Sciences: 111 (42)

New Research In

October 21, 2014; vol. 111 no. 42

This Week in PNAS

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In This Issue
PNAS October 21, 2014 111 (42) 14961-14962; https://doi.org/10.1073/iti4214111

Letters (Online Only)

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Gluconeogenesis in cancer: Door wide open
Katharina Leithner, Andelko Hrzenjak, and Horst Olschewski

PNAS October 21, 2014 111 (42) E4394; first published September 26, 2014. https://doi.org/10.1073/pnas.1415680111
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Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): A target of the p53-SIRT6-FoxO1 axis
Zhiming Li and Wei-Guo Zhu

PNAS October 21, 2014 111 (42) E4395; first published September 26, 2014. https://doi.org/10.1073/pnas.1416664111
See companion article:
p53 activates SIRT6 to regulate gluconeogenesis
- Jul 09, 2014
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Still no convincing evidence for cognitive map use by honeybees
Allen Cheung, Matthew Collett, Thomas S. Collett, Alex Dewar, Fred Dyer, Paul Graham, Michael Mangan, Ajay Narendra, Andrew Philippides, Wolfgang Stürzl, Barbara Webb, Antoine Wystrach, and Jochen Zeil

PNAS October 21, 2014 111 (42) E4396-E4397; first published October 2, 2014. https://doi.org/10.1073/pnas.1413581111
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Reply to Cheung et al.: The cognitive map hypothesis remains the best interpretation of the data in honeybee navigation
James F. Cheeseman, Craig D. Millar, Uwe Greggers, Konstantin Lehmann, Matthew D. M. Pawley, Charles R. Gallistel, Guy R. Warman, and Randolf Menzel

PNAS October 21, 2014 111 (42) E4398; first published October 2, 2014. https://doi.org/10.1073/pnas.1415738111
See companion article:
The bee reads its map
- Jun 02, 2014

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: Roboclam
Front Matter
Calla Cofield

PNAS October 21, 2014 111 (42) 14963; https://doi.org/10.1073/pnas.1410527111

Retrospective

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Woody Hastings: 65 years of fun
E. Peter Greenberg, Kenneth H. Nealson, and Carl Hirschie Johnson

PNAS October 21, 2014 111 (42) 14964-14965; first published September 30, 2014. https://doi.org/10.1073/pnas.1415972111

Commentaries

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From fear recognition to kidney donation
Joshua D. Greene

PNAS October 21, 2014 111 (42) 14966-14967; first published October 9, 2014. https://doi.org/10.1073/pnas.1416960111
See companion article:
Characteristics of extraordinary altruists
- Sep 15, 2014
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Multiple origins of serpentine-soil endemism explained by preexisting tolerance of open habitats
W. Scott Armbruster

PNAS October 21, 2014 111 (42) 14968-14969; first published October 13, 2014. https://doi.org/10.1073/pnas.1417242111
See companion article:
Life in bare habitats a precursor of soil endemism
- Sep 29, 2014

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS October 21, 2014 111 (42) 14970-14972; https://doi.org/10.1073/pnas.ss11142

Physical Sciences

Applied Mathematics
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  Universality in numerical computations with random data
  Percy A. Deift, Govind Menon, Sheehan Olver, and Thomas Trogdon
  
  PNAS October 21, 2014 111 (42) 14973-14978; first published September 24, 2014. https://doi.org/10.1073/pnas.1413446111
Applied Physical Sciences
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  Multivariate biophysical markers predictive of mesenchymal stromal cell multipotency
  Wong Cheng Lee, Hui Shi, Zhiyong Poon, Lin Myint Nyan, Tanwi Kaushik, G. V. Shivashankar, Jerry K. Y. Chan, Chwee Teck Lim, Jongyoon Han, and Krystyn J. Van Vliet
  
  PNAS October 21, 2014 111 (42) E4409-E4418; first published October 8, 2014. https://doi.org/10.1073/pnas.1402306111
- Open Access
  Intrinsic conduction through topological surface states of insulating Bi₂Te₃ epitaxial thin films
  Katharina Hoefer, Christoph Becker, Diana Rata, Jesse Swanson, Peter Thalmeier, and L. H. Tjeng
  
  PNAS October 21, 2014 111 (42) 14979-14984; first published October 7, 2014. https://doi.org/10.1073/pnas.1410591111
Chemistry
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  Label-free electrochemical detection of human methyltransferase from tumors
  Ariel L. Furst, Natalie B. Muren, Michael G. Hill, and Jacqueline K. Barton
  
  PNAS October 21, 2014 111 (42) 14985-14989; first published October 6, 2014. https://doi.org/10.1073/pnas.1417351111
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  Ultraefficient homogeneous catalyst for the CO₂-to-CO electrochemical conversion
  From the Cover
  
  Cyrille Costentin, Guillaume Passard, Marc Robert, and Jean-Michel Savéant
  
  PNAS October 21, 2014 111 (42) 14990-14994; first published October 6, 2014. https://doi.org/10.1073/pnas.1416697111
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  Importance of the DNA “bond” in programmable nanoparticle crystallization
  Robert J. Macfarlane, Ryan V. Thaner, Keith A. Brown, Jian Zhang, Byeongdu Lee, SonBinh T. Nguyen, and Chad A. Mirkin
  
  PNAS October 21, 2014 111 (42) 14995-15000; first published October 8, 2014. https://doi.org/10.1073/pnas.1416489111
- Open Access
  Role of pendant proton relays and proton-coupled electron transfer on the hydrogen evolution reaction by nickel hangman porphyrins
  D. Kwabena Bediako, Brian H. Solis, Dilek K. Dogutan, Manolis M. Roubelakis, Andrew G. Maher, Chang Hoon Lee, Matthew B. Chambers, Sharon Hammes-Schiffer, and Daniel G. Nocera
  
  PNAS October 21, 2014 111 (42) 15001-15006; first published October 8, 2014. https://doi.org/10.1073/pnas.1414908111
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  Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis
  David Calligaris, Diana Caragacianu, Xiaohui Liu, Isaiah Norton, Christopher J. Thompson, Andrea L. Richardson, Mehra Golshan, Michael L. Easterling, Sandro Santagata, Deborah A. Dillon, Ferenc A. Jolesz, and Nathalie Y. R. Agar
  
  PNAS October 21, 2014 111 (42) 15184-15189; first published September 22, 2014. https://doi.org/10.1073/pnas.1408129111
Earth, Atmospheric, and Planetary Sciences
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  The negligible chondritic contribution in the lunar soils water
  Alice Stephant and François Robert
  
  PNAS October 21, 2014 111 (42) 15007-15012; first published October 6, 2014. https://doi.org/10.1073/pnas.1408118111
Engineering
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  Discrete elements for 3D microfluidics
  From the Cover
  
  Krisna C. Bhargava, Bryant Thompson, and Noah Malmstadt
  
  PNAS October 21, 2014 111 (42) 15013-15018; first published September 22, 2014. https://doi.org/10.1073/pnas.1414764111
Environmental Sciences
- Open Access
  Neutral molecular cluster formation of sulfuric acid–dimethylamine observed in real time under atmospheric conditions
  Andreas Kürten, Tuija Jokinen, Mario Simon, Mikko Sipilä, Nina Sarnela, Heikki Junninen, Alexey Adamov, João Almeida, Antonio Amorim, Federico Bianchi, Martin Breitenlechner, Josef Dommen, Neil M. Donahue, Jonathan Duplissy, Sebastian Ehrhart, Richard C. Flagan, Alessandro Franchin, Jani Hakala, Armin Hansel, Martin Heinritzi, Manuel Hutterli, Juha Kangasluoma, Jasper Kirkby, Ari Laaksonen, Katrianne Lehtipalo, Markus Leiminger, Vladimir Makhmutov, Serge Mathot, Antti Onnela, Tuukka Petäjä, Arnaud P. Praplan, Francesco Riccobono, Matti P. Rissanen, Linda Rondo, Siegfried Schobesberger, John H. Seinfeld, Gerhard Steiner, António Tomé, Jasmin Tröstl, Paul M. Winkler, Christina Williamson, Daniela Wimmer, Penglin Ye, Urs Baltensperger, Kenneth S. Carslaw, Markku Kulmala, Douglas R. Worsnop, and Joachim Curtius
  
  PNAS October 21, 2014 111 (42) 15019-15024; first published October 6, 2014. https://doi.org/10.1073/pnas.1404853111
Physics
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  Hopping and the Stokes–Einstein relation breakdown in simple glass formers
  Patrick Charbonneau, Yuliang Jin, Giorgio Parisi, and Francesco Zamponi
  
  PNAS October 21, 2014 111 (42) 15025-15030; first published October 6, 2014. https://doi.org/10.1073/pnas.1417182111
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  Part-crystalline part-liquid state and rattling-like thermal damping in materials with chemical-bond hierarchy
  Wujie Qiu, Lili Xi, Ping Wei, Xuezhi Ke, Jihui Yang, and Wenqing Zhang
  
  PNAS October 21, 2014 111 (42) 15031-15035; first published October 6, 2014. https://doi.org/10.1073/pnas.1410349111
Sustainability Science
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  Tracking sustainable development with a national barometer for South Africa using a downscaled “safe and just space” framework
  Megan J. Cole, Richard M. Bailey, and Mark G. New
  
  PNAS October 21, 2014 111 (42) E4399-E4408; first published October 7, 2014. https://doi.org/10.1073/pnas.1400985111

Biological Sciences

Applied Biological Sciences
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  Multivariate biophysical markers predictive of mesenchymal stromal cell multipotency
  Wong Cheng Lee, Hui Shi, Zhiyong Poon, Lin Myint Nyan, Tanwi Kaushik, G. V. Shivashankar, Jerry K. Y. Chan, Chwee Teck Lim, Jongyoon Han, and Krystyn J. Van Vliet
  
  PNAS October 21, 2014 111 (42) E4409-E4418; first published October 8, 2014. https://doi.org/10.1073/pnas.1402306111
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  Intrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors
  Anna J. Simon, Alexis Vallée-Bélisle, Francesco Ricci, and Kevin W. Plaxco
  
  PNAS October 21, 2014 111 (42) 15048-15053; first published October 6, 2014. https://doi.org/10.1073/pnas.1410796111
Biochemistry
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  Label-free electrochemical detection of human methyltransferase from tumors
  Ariel L. Furst, Natalie B. Muren, Michael G. Hill, and Jacqueline K. Barton
  
  PNAS October 21, 2014 111 (42) 14985-14989; first published October 6, 2014. https://doi.org/10.1073/pnas.1417351111
- Open Access
  The signaling phospholipid PIP₃ creates a new interaction surface on the nuclear receptor SF-1
  Raymond D. Blind, Elena P. Sablin, Kristopher M. Kuchenbecker, Hsiu-Ju Chiu, Ashley M. Deacon, Debanu Das, Robert J. Fletterick, and Holly A. Ingraham
  
  PNAS October 21, 2014 111 (42) 15054-15059; first published October 6, 2014. https://doi.org/10.1073/pnas.1416740111
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  Following movement of domain IV of elongation factor G during ribosomal translocation
  Enea Salsi, Elie Farah, Jillian Dann, and Dmitri N. Ermolenko
  
  PNAS October 21, 2014 111 (42) 15060-15065; first published October 6, 2014. https://doi.org/10.1073/pnas.1410873111
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  Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution
  Bijoy J. Desai, Yuki Goto, Alessandro Cembran, Alexander A. Fedorov, Steven C. Almo, Jiali Gao, Hiroaki Suga, and John A. Gerlt
  
  PNAS October 21, 2014 111 (42) 15066-15071; first published October 1, 2014. https://doi.org/10.1073/pnas.1411772111
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  Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
  Joanne M. Hildebrand, Maria C. Tanzer, Isabelle S. Lucet, Samuel N. Young, Sukhdeep K. Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick C. J. Dobson, Andrew I. Webb, Anne Tripaydonis, Jeffrey J. Babon, Mark D. Mulcair, Martin J. Scanlon, Warren S. Alexander, Andrew F. Wilks, Peter E. Czabotar, Guillaume Lessene, James M. Murphy, and John Silke
  
  PNAS October 21, 2014 111 (42) 15072-15077; first published October 6, 2014. https://doi.org/10.1073/pnas.1408987111
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  KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes
  Dong-In Koh, Dohyun Han, Hoon Ryu, Won-Il Choi, Bu-Nam Jeon, Min-Kyeong Kim, Youngsoo Kim, Jin Young Kim, Lee Parry, Alan R. Clarke, Albert B. Reynolds, and Man-Wook Hur
  
  PNAS October 21, 2014 111 (42) 15078-15083; first published October 6, 2014. https://doi.org/10.1073/pnas.1318780111
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  Structure of the ArgRS–GlnRS–AIMP1 complex and its implications for mammalian translation
  Yaoyao Fu, Youngran Kim, Kyeong Sik Jin, Hyun Sook Kim, Jong Hyun Kim, DongMing Wang, Minyoung Park, Chang Hwa Jo, Nam Hoon Kwon, Doyeun Kim, Myung Hee Kim, Young Ho Jeon, Kwang Yeon Hwang, Sunghoon Kim, and Yunje Cho
  
  PNAS October 21, 2014 111 (42) 15084-15089; first published October 6, 2014. https://doi.org/10.1073/pnas.1408836111
Biophysics and Computational Biology
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  Conformational coupling between the active site and residues within the K^C-channel of the Vibrio cholerae cbb₃-type (C-family) oxygen reductase
  Young O. Ahn, Paween Mahinthichaichan, Hyun Ju Lee, Hanlin Ouyang, Daniel Kaluka, Syun-Ru Yeh, Davinia Arjona, Denis L. Rousseau, Emad Tajkhorshid, Pia Ädelroth, and Robert B. Gennis
  
  PNAS October 21, 2014 111 (42) E4419-E4428; first published October 6, 2014. https://doi.org/10.1073/pnas.1411676111
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  Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution
  Andrea Candelli, Jan Thomas Holthausen, Martin Depken, Ineke Brouwer, Mariëlla A. M. Franker, Margherita Marchetti, Iddo Heller, Stéphanie Bernard, Edwige B. Garcin, Mauro Modesti, Claire Wyman, Gijs J. L. Wuite, and Erwin J. G. Peterman
  
  PNAS October 21, 2014 111 (42) 15090-15095; first published October 6, 2014. https://doi.org/10.1073/pnas.1307824111
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  Single-molecule packaging initiation in real time by a viral DNA packaging machine from bacteriophage T4
  Reza Vafabakhsh, Kiran Kondabagil, Tyler Earnest, Kyung Suk Lee, Zhihong Zhang, Li Dai, Karin A. Dahmen, Venigalla B. Rao, and Taekjip Ha
  
  PNAS October 21, 2014 111 (42) 15096-15101; first published October 6, 2014. https://doi.org/10.1073/pnas.1407235111
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  Computational design of a self-assembling symmetrical β-propeller protein
  Arnout R. D. Voet, Hiroki Noguchi, Christine Addy, David Simoncini, Daiki Terada, Satoru Unzai, Sam-Yong Park, Kam Y. J. Zhang, and Jeremy R. H. Tame
  
  PNAS October 21, 2014 111 (42) 15102-15107; first published October 6, 2014. https://doi.org/10.1073/pnas.1412768111
Cell Biology
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  Role of Erbin in ErbB2-dependent breast tumor growth
  Yanmei Tao, Chengyong Shen, Shiwen Luo, Wilfried Traoré, Sylvie Marchetto, Marie-Josée Santoni, Linlin Xu, Biao Wu, Chao Shi, Jinghong Mei, Ryan Bates, Xihui Liu, Kai Zhao, Wen-Cheng Xiong, Jean-Paul Borg, and Lin Mei
  
  PNAS October 21, 2014 111 (42) E4429-E4438; first published October 6, 2014. https://doi.org/10.1073/pnas.1407139111
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  Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
  Yvette C. Wong and Erika L. F. Holzbaur
  
  PNAS October 21, 2014 111 (42) E4439-E4448; first published October 7, 2014. https://doi.org/10.1073/pnas.1405752111
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  Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration
  Juliette Sailland, Violaine Tribollet, Christelle Forcet, Cyrielle Billon, Bruno Barenton, Julie Carnesecchi, Alice Bachmann, Karine Cécile Gauthier, Shan Yu, Vincent Giguère, Franky L. Chan, and Jean-Marc Vanacker
  
  PNAS October 21, 2014 111 (42) 15108-15113; first published October 6, 2014. https://doi.org/10.1073/pnas.1402094111
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  Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration
  From the Cover
  
  Yvonne Leung, Eve Kandyba, Yi-Bu Chen, Seth Ruffins, Cheng-Ming Chuong, and Krzysztof Kobielak
  
  PNAS October 21, 2014 111 (42) 15114-15119; first published October 2, 2014. https://doi.org/10.1073/pnas.1318848111
Ecology
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  Recent mountain pine beetle outbreaks, wildfire severity, and postfire tree regeneration in the US Northern Rockies
  Brian J. Harvey, Daniel C. Donato, and Monica G. Turner
  
  PNAS October 21, 2014 111 (42) 15120-15125; first published September 29, 2014. https://doi.org/10.1073/pnas.1411346111
- Open Access
  Behavior of bats at wind turbines
  Paul. M. Cryan, P. Marcos Gorresen, Cris D. Hein, Michael R. Schirmacher, Robert H. Diehl, Manuela M. Huso, David T. S. Hayman, Paul D. Fricker, Frank J. Bonaccorso, Douglas H. Johnson, Kevin Heist, and David C. Dalton
  
  PNAS October 21, 2014 111 (42) 15126-15131; first published September 29, 2014. https://doi.org/10.1073/pnas.1406672111
Evolution
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  Occupation of bare habitats, an evolutionary precursor to soil specialization in plants
  From the Cover
  
  N. Ivalú Cacho and Sharon Y. Strauss
  
  PNAS October 21, 2014 111 (42) 15132-15137; first published September 29, 2014. https://doi.org/10.1073/pnas.1409242111
  
  See companion article:
  Evolution of edaphic endemics
  - Oct 13, 2014
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  Tug-of-war between driver and passenger mutations in cancer and other adaptive processes
  Christopher D. McFarland, Leonid A. Mirny, and Kirill S. Korolev
  
  PNAS October 21, 2014 111 (42) 15138-15143; first published October 2, 2014. https://doi.org/10.1073/pnas.1404341111
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  Sexual selection on wing interference patterns in Drosophila melanogaster
  Natsu Katayama, Jessica K. Abbott, Jostein Kjærandsen, Yuma Takahashi, and Erik I. Svensson
  
  PNAS October 21, 2014 111 (42) 15144-15148; first published October 7, 2014. https://doi.org/10.1073/pnas.1407595111
- Open Access
  Allopolyploidy, diversification, and the Miocene grassland expansion
  Matt C. Estep, Michael R. McKain, Dilys Vela Diaz, Jinshun Zhong, John G. Hodge, Trevor R. Hodkinson, Daniel J. Layton, Simon T. Malcomber, Rémy Pasquet, and Elizabeth A. Kellogg
  
  PNAS October 21, 2014 111 (42) 15149-15154; first published October 6, 2014. https://doi.org/10.1073/pnas.1404177111
Genetics
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  Quantitation of interactions between two DNA loops demonstrates loop domain insulation in E. coli cells
  David G. Priest, Sandip Kumar, Yan Yan, David D. Dunlap, Ian B. Dodd, and Keith E. Shearwin
  
  PNAS October 21, 2014 111 (42) E4449-E4457; first published October 6, 2014. https://doi.org/10.1073/pnas.1410764111
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  Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans
  Ara B. Hwang, Eun-A Ryu, Murat Artan, Hsin-Wen Chang, Mohammad Humayun Kabir, Hyun-Jun Nam, Dongyeop Lee, Jae-Seong Yang, Sanguk Kim, William B. Mair, Cheolju Lee, Siu Sylvia Lee, and Seung-Jae Lee
  
  PNAS October 21, 2014 111 (42) E4458-E4467; first published October 6, 2014. https://doi.org/10.1073/pnas.1411199111
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  CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors
  Aarathi Sugathan, Marta Biagioli, Christelle Golzio, Serkan Erdin, Ian Blumenthal, Poornima Manavalan, Ashok Ragavendran, Harrison Brand, Diane Lucente, Judith Miles, Steven D. Sheridan, Alexei Stortchevoi, Manolis Kellis, Stephen J. Haggarty, Nicholas Katsanis, James F. Gusella, and Michael E. Talkowski
  
  PNAS October 21, 2014 111 (42) E4468-E4477; first published October 7, 2014. https://doi.org/10.1073/pnas.1405266111
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  Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway
  Matthias Drosten, Eleanor Y. M. Sum, Carmen G. Lechuga, Lucía Simón-Carrasco, Harrys K. C. Jacob, Raquel García-Medina, Sidong Huang, Roderick L. Beijersbergen, Rene Bernards, and Mariano Barbacid
  
  PNAS October 21, 2014 111 (42) 15155-15160; first published October 6, 2014. https://doi.org/10.1073/pnas.1417549111
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  Autism spectrum disorder severity reflects the average contribution of de novo and familial influences
  Elise B. Robinson, Kaitlin E. Samocha, Jack A. Kosmicki, Lauren McGrath, Benjamin M. Neale, Roy H. Perlis, and Mark J. Daly
  
  PNAS October 21, 2014 111 (42) 15161-15165; first published October 6, 2014. https://doi.org/10.1073/pnas.1409204111
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  Role for LSM genes in the regulation of circadian rhythms
  Soledad Perez-Santángelo, Estefanía Mancini, Lauren J. Francey, Ruben Gustavo Schlaen, Ariel Chernomoretz, John B. Hogenesch, and Marcelo J. Yanovsky
  
  PNAS October 21, 2014 111 (42) 15166-15171; first published October 6, 2014. https://doi.org/10.1073/pnas.1409791111
- Open Access
  Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer
  Johanna I. Kiiski, Liisa M. Pelttari, Sofia Khan, Edda S. Freysteinsdottir, Inga Reynisdottir, Steven N. Hart, Hermela Shimelis, Sara Vilske, Anne Kallioniemi, Johanna Schleutker, Arto Leminen, Ralf Bützow, Carl Blomqvist, Rosa B. Barkardottir, Fergus J. Couch, Kristiina Aittomäki, and Heli Nevanlinna
  
  PNAS October 21, 2014 111 (42) 15172-15177; first published October 6, 2014. https://doi.org/10.1073/pnas.1407909111
Immunology and Inflammation
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  Human TLR10 is an anti-inflammatory pattern-recognition receptor
  Marije Oosting, Shih-Chin Cheng, Judith M. Bolscher, Rachel Vestering-Stenger, Theo S. Plantinga, Ineke C. Verschueren, Peer Arts, Anja Garritsen, Hans van Eenennaam, Patrick Sturm, Bart-Jan Kullberg, Alexander Hoischen, Gosse J. Adema, Jos W. M. van der Meer, Mihai G. Netea, and Leo A. B. Joosten
  
  PNAS October 21, 2014 111 (42) E4478-E4484; first published October 6, 2014. https://doi.org/10.1073/pnas.1410293111
- Open Access
  Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity
  Sophie Leclercq, Sébastien Matamoros, Patrice D. Cani, Audrey M. Neyrinck, François Jamar, Peter Stärkel, Karen Windey, Valentina Tremaroli, Fredrik Bäckhed, Kristin Verbeke, Philippe de Timary, and Nathalie M. Delzenne
  
  PNAS October 21, 2014 111 (42) E4485-E4493; first published October 6, 2014. https://doi.org/10.1073/pnas.1415174111
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  Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells
  Yuchun Luo, Xiangna Cai, Sucai Liu, Sen Wang, Claudia A. Nold-Petry, Marcel F. Nold, Philip Bufler, David Norris, Charles A. Dinarello, and Mayumi Fujita
  
  PNAS October 21, 2014 111 (42) 15178-15183; first published October 7, 2014. https://doi.org/10.1073/pnas.1416714111
Medical Sciences
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  LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity
  Mylène Tajan, Aurélie Batut, Thomas Cadoudal, Simon Deleruyelle, Sophie Le Gonidec, Céline Saint Laurent, Maëlle Vomscheid, Estelle Wanecq, Karine Tréguer, Audrey De Rocca Serra-Nédélec, Claire Vinel, Marie-Adeline Marques, Joffrey Pozzo, Oksana Kunduzova, Jean-Pierre Salles, Maithé Tauber, Patrick Raynal, Hélène Cavé, Thomas Edouard, Philippe Valet, and Armelle Yart
  
  PNAS October 21, 2014 111 (42) E4494-E4503; first published October 6, 2014. https://doi.org/10.1073/pnas.1406107111
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  Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers
  Yuan Lin, Haipeng Zhang, Jiankai Liang, Kai Li, Wenbo Zhu, Liwu Fu, Fang Wang, Xiaoke Zheng, Huijuan Shi, Sihan Wu, Xiao Xiao, Lijun Chen, Lipeng Tang, Min Yan, Xiaoxiao Yang, Yaqian Tan, Pengxin Qiu, Yijun Huang, Wei Yin, Xinwen Su, Haiyan Hu, Jun Hu, and Guangmei Yan
  
  PNAS October 21, 2014 111 (42) E4504-E4512; first published October 6, 2014. https://doi.org/10.1073/pnas.1408759111
- Open Access
  Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma
  Stephan Kreher, M. Amine Bouhlel, Pierre Cauchy, Björn Lamprecht, Shuang Li, Michael Grau, Franziska Hummel, Karl Köchert, Ioannis Anagnostopoulos, Korinna Jöhrens, Michael Hummel, John Hiscott, Sören-Sebastian Wenzel, Peter Lenz, Markus Schneider, Ralf Küppers, Claus Scheidereit, Maciej Giefing, Reiner Siebert, Klaus Rajewsky, Georg Lenz, Peter N. Cockerill, Martin Janz, Bernd Dörken, Constanze Bonifer, and Stephan Mathas
  
  PNAS October 21, 2014 111 (42) E4513-E4522; first published October 6, 2014. https://doi.org/10.1073/pnas.1406985111
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  PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine
  Elena Bellafante, Annalisa Morgano, Lorena Salvatore, Stefania Murzilli, Giuseppe Di Tullio, Andria D’Orazio, Dominga Latorre, Gaetano Villani, and Antonio Moschetta
  
  PNAS October 21, 2014 111 (42) E4523-E4531; first published October 6, 2014. https://doi.org/10.1073/pnas.1415279111
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  Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis
  David Calligaris, Diana Caragacianu, Xiaohui Liu, Isaiah Norton, Christopher J. Thompson, Andrea L. Richardson, Mehra Golshan, Michael L. Easterling, Sandro Santagata, Deborah A. Dillon, Ferenc A. Jolesz, and Nathalie Y. R. Agar
  
  PNAS October 21, 2014 111 (42) 15184-15189; first published September 22, 2014. https://doi.org/10.1073/pnas.1408129111
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  JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response
  Edwin Chen, Jong Sook Ahn, Charlie E. Massie, David Clynes, Anna L. Godfrey, Juan Li, Hyun Jung Park, Jyoti Nangalia, Yvonne Silber, Ann Mullally, Richard J. Gibbons, and Anthony R. Green
  
  PNAS October 21, 2014 111 (42) 15190-15195; first published October 6, 2014. https://doi.org/10.1073/pnas.1401873111
- Open Access
  Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure
  Claudia Crocini, Raffaele Coppini, Cecilia Ferrantini, Ping Yan, Leslie M. Loew, Chiara Tesi, Elisabetta Cerbai, Corrado Poggesi, Francesco S. Pavone, and Leonardo Sacconi
  
  PNAS October 21, 2014 111 (42) 15196-15201; first published October 6, 2014. https://doi.org/10.1073/pnas.1411557111
Microbiology
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  Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization
  Nikolina Udikovic-Kolic, Fabienne Wichmann, Nichole A. Broderick, and Jo Handelsman
  
  PNAS October 21, 2014 111 (42) 15202-15207; first published October 6, 2014. https://doi.org/10.1073/pnas.1409836111
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  Structural studies on the authentic mumps virus nucleocapsid showing uncoiling by the phosphoprotein
  Robert Cox, Adrian Pickar, Shihong Qiu, Jun Tsao, Cynthia Rodenburg, Terje Dokland, Andrew Elson, Biao He, and Ming Luo
  
  PNAS October 21, 2014 111 (42) 15208-15213; first published October 6, 2014. https://doi.org/10.1073/pnas.1413268111
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  Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein
  Jean Kaoru Millet and Gary R. Whittaker
  
  PNAS October 21, 2014 111 (42) 15214-15219; first published October 6, 2014. https://doi.org/10.1073/pnas.1407087111
Neuroscience
- Open Access
  Autism as a disorder of prediction
  Pawan Sinha, Margaret M. Kjelgaard, Tapan K. Gandhi, Kleovoulos Tsourides, Annie L. Cardinaux, Dimitrios Pantazis, Sidney P. Diamond, and Richard M. Held
  
  PNAS October 21, 2014 111 (42) 15220-15225; first published October 6, 2014. https://doi.org/10.1073/pnas.1416797111
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  Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion
  Yasufumi Hayano, Kensuke Sasaki, Nami Ohmura, Makoto Takemoto, Yurie Maeda, Toshihide Yamashita, Yoshio Hata, Kazuhiro Kitada, and Nobuhiko Yamamoto
  
  PNAS October 21, 2014 111 (42) 15226-15231; first published October 6, 2014. https://doi.org/10.1073/pnas.1402095111
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  GABA_B(1) receptor subunit isoforms differentially regulate stress resilience
  Olivia F. O’Leary, Daniela Felice, Stefano Galimberti, Hélène M. Savignac, Javier A. Bravo, Tadhg Crowley, Malika El Yacoubi, Jean-Marie Vaugeois, Martin Gassmann, Bernhard Bettler, Timothy G. Dinan, and John F. Cryan
  
  PNAS October 21, 2014 111 (42) 15232-15237; first published October 6, 2014. https://doi.org/10.1073/pnas.1404090111
- Open Access
  Left–right dissociation of hippocampal memory processes in mice
  Olivia A. Shipton, Mohamady El-Gaby, John Apergis-Schoute, Karl Deisseroth, David M. Bannerman, Ole Paulsen, and Michael M. Kohl
  
  PNAS October 21, 2014 111 (42) 15238-15243; first published September 22, 2014. https://doi.org/10.1073/pnas.1405648111
- Open Access
  Cross-modal effects of value on perceptual acuity and stimulus encoding
  Arezoo Pooresmaeili, Thomas H. B. FitzGerald, Dominik R. Bach, Ulf Toelch, Florian Ostendorf, and Raymond J. Dolan
  
  PNAS October 21, 2014 111 (42) 15244-15249; first published October 6, 2014. https://doi.org/10.1073/pnas.1408873111
Physiology
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  Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging
  Alisa Umanskaya, Gaetano Santulli, Wenjun Xie, Daniel C. Andersson, Steven R. Reiken, and Andrew R. Marks
  
  PNAS October 21, 2014 111 (42) 15250-15255; first published October 6, 2014. https://doi.org/10.1073/pnas.1412754111
- Open Access
  Cold and hunger induce diurnality in a nocturnal mammal
  Vincent van der Vinne, Sjaak J. Riede, Jenke A. Gorter, Willem G. Eijer, Michael T. Sellix, Michael Menaker, Serge Daan, Violetta Pilorz, and Roelof A. Hut
  
  PNAS October 21, 2014 111 (42) 15256-15260; first published October 6, 2014. https://doi.org/10.1073/pnas.1413135111
Plant Biology
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  Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress
  Antonio Chaves-Sanjuan, Maria Jose Sanchez-Barrena, Juana Maria Gonzalez-Rubio, Maria Moreno, Paula Ragel, Marta Jimenez, Jose M. Pardo, Martin Martinez-Ripoll, Francisco J. Quintero, and Armando Albert
  
  PNAS October 21, 2014 111 (42) E4532-E4541; first published October 6, 2014. https://doi.org/10.1073/pnas.1407610111
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  A receptor-like protein mediates the response to pectin modification by activating brassinosteroid signaling
  Sebastian Wolf, Dieuwertje van der Does, Friederike Ladwig, Carsten Sticht, Andreas Kolbeck, Ann-Kathrin Schürholz, Sebastian Augustin, Nana Keinath, Thomas Rausch, Steffen Greiner, Karin Schumacher, Klaus Harter, Cyril Zipfel, and Herman Höfte
  
  PNAS October 21, 2014 111 (42) 15261-15266; first published October 6, 2014. https://doi.org/10.1073/pnas.1322979111
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  Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway
  Peizhu Guan, Rongchen Wang, Philippe Nacry, Ghislain Breton, Steve A. Kay, Jose L. Pruneda-Paz, Ariea Davani, and Nigel M. Crawford
  
  PNAS October 21, 2014 111 (42) 15267-15272; first published October 6, 2014. https://doi.org/10.1073/pnas.1411375111
Psychological and Cognitive Sciences
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  Neural and cognitive characteristics of extraordinary altruists
  From the Cover
  
  Cozzarelli Prize Winner
  
  Abigail A. Marsh, Sarah A. Stoycos, Kristin M. Brethel-Haurwitz, Paul Robinson, John W. VanMeter, and Elise M. Cardinale
  
  PNAS October 21, 2014 111 (42) 15036-15041; first published September 15, 2014. https://doi.org/10.1073/pnas.1408440111
  
  See companion article:
  From fear recognition to kidney donation
  - Oct 09, 2014
- Open Access
  The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence
  Eva Krapohl, Kaili Rimfeld, Nicholas G. Shakeshaft, Maciej Trzaskowski, Andrew McMillan, Jean-Baptiste Pingault, Kathryn Asbury, Nicole Harlaar, Yulia Kovas, Philip S. Dale, and Robert Plomin
  
  PNAS October 21, 2014 111 (42) 15273-15278; first published October 6, 2014. https://doi.org/10.1073/pnas.1408777111

Correction

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Correction for Betts et al., Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages
PNAS October 21, 2014 111 (42) 15279; first published September 30, 2014. https://doi.org/10.1073/pnas.1418380111

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