Better explicating the strengths and shortcomings of these models will help refine projections and improve transparency in the years ahead.
Image credit: Witsawat.S.
Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved September 15, 2014 (received for review July 7, 2014)
Significance
Because obese people are at an increased risk of many age-related diseases, it is a plausible hypothesis that obesity increases the biological age of some tissues and cell types. However, it has been difficult to detect such an accelerated aging effect because it is unclear how to measure tissue age. Here we use a recently developed biomarker of aging (known as “epigenetic clock”) to study the relationship between epigenetic age and obesity in several human tissues. We report an unexpectedly strong correlation between high body mass index and the epigenetic age of liver tissue. This finding may explain why obese people suffer from the early onset of many age-related pathologies, including liver cancer.
Abstract
Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an “epigenetic clock”) to study the relationship between high body mass index (BMI) and the DNA methylation ages of human blood, liver, muscle, and adipose tissue. A significant correlation between BMI and epigenetic age acceleration could only be observed for liver (r = 0.42, P = 6.8 × 10−4 in dataset 1 and r = 0.42, P = 1.2 × 10−4 in dataset 2). On average, epigenetic age increased by 3.3 y for each 10 BMI units. The detected age acceleration in liver is not associated with the Nonalcoholic Fatty Liver Disease Activity Score or any of its component traits after adjustment for BMI. The 279 genes that are underexpressed in older liver samples are highly enriched (1.2 × 10−9) with nuclear mitochondrial genes that play a role in oxidative phosphorylation and electron transport. The epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer.
Footnotes
- ↵1To whom correspondence should be addressed. Email: shorvath{at}mednet.ucla.edu.
↵2C.S. and J.H. contributed equally to this work.
Author contributions: S.H. and J.H. designed research; S.H. performed research; S.H., W.E., M.B., O.A., W.v.S., M.A., N.H., J.T.B., P.-C.T., T.D.S., P.D., R.S., B.S., T.B., C.R., C.S., and J.H. contributed new reagents/analytic tools; S.H. and P.-C.T. analyzed data; and S.H. and J.H. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
Data deposition: The data reported in this paper have been deposited in the Gene Expression Omnibus (GEO) database, www.ncbi.nlm.nih.gov/geo (accession no. GSE61256).
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1412759111/-/DCSupplemental.
Freely available online through the PNAS open access option.
Obesity accelerates epigenetic aging
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