Proceedings of the National Academy of Sciences: 111 (45)

New Research In

November 11, 2014; vol. 111 no. 45

This Week in PNAS

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In This Issue
PNAS November 11, 2014 111 (45) 15853-15854; https://doi.org/10.1073/iti4514111

Letters (Online Only)

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Using multielement isotopic analysis to decipher drought impacts and adaptive management in ancient agricultural systems
Toby M. Maxwell, Lucas C. R. Silva, and William R. Horwath

PNAS November 11, 2014 111 (45) E4807-E4808; first published November 3, 2014. https://doi.org/10.1073/pnas.1417618111
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Reply to Maxwell et al.: Stable isotopes and their potential for interpreting archaeobotanical remains
Simone Riehl and Konstantin E. Pustovoytov

PNAS November 11, 2014 111 (45) E4809; first published November 3, 2014. https://doi.org/10.1073/pnas.1418161111
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Drought stress variability in ancient Near Eastern agricultural systems evidenced by δ¹³C in barley grain
- Aug 26, 2014
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Not surprisingly, no inheritance of a trait results in no evolution
Philip W. Hedrick, David W. Coltman, Marco Festa-Bianchet, and Fanie Pelletier

PNAS November 11, 2014 111 (45) E4810; first published November 3, 2014. https://doi.org/10.1073/pnas.1416665111
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Reply to Hedrick et al.: Trophy hunting influences the distribution of trait values through demographic impacts
Lochran W. Traill, Susanne Schindler, and Tim Coulson

PNAS November 11, 2014 111 (45) E4811; first published November 3, 2014. https://doi.org/10.1073/pnas.1418475111
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Demography, not inheritance, drives phenotypic change in hunted bighorn sheep
- Sep 09, 2014

Opinion

Leading scientists discuss current issues.

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Opinion: Building a 21st-century infrastructure for the social sciences
Front Matter
Emilio F. Moran, Sandra L. Hofferth, Catherine C. Eckel, Darrick Hamilton, Barbara Entwisle, J. Lawrence Aber, Henry E. Brady, Dalton Conley, Susan L. Cutter, Klaus Hubacek, and John T. Scholz

PNAS November 11, 2014 111 (45) 15855-15856; https://doi.org/10.1073/pnas.1416561111

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: Breaking down bees' dances
Front Matter
Helen H. Shen

PNAS November 11, 2014 111 (45) 15857; https://doi.org/10.1073/pnas.1417032111

Profile

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Profile of Christos Papadimitriou
Farooq Ahmed

PNAS November 11, 2014 111 (45) 15858-15860; first published October 27, 2014. https://doi.org/10.1073/pnas.1405579111
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Algorithms, complexity, and the sciences
- Nov 11, 2014

Commentaries

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Closing the sea level budget at the Last Glacial Maximum
Peter U. Clark and Lev Tarasov

PNAS November 11, 2014 111 (45) 15861-15862; first published November 3, 2014. https://doi.org/10.1073/pnas.1418970111
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Sea level and global ice volumes from the Last Glacial Maximum to the Holocene
- Oct 28, 2014
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A simple theoretical model goes a long way in explaining complex behavior in protein folding
Victor Muñoz

PNAS November 11, 2014 111 (45) 15863-15864; first published October 27, 2014. https://doi.org/10.1073/pnas.1418039111
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Folding pathway of a multidomain protein depends on its topology of domain connectivity
- Nov 11, 2014
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Horizontal transfer beyond genes
Eugene V. Koonin

PNAS November 11, 2014 111 (45) 15865-15866; first published October 30, 2014. https://doi.org/10.1073/pnas.1418789111
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Transfer of noncoding DNA drives regulatory rewiring in bacteria
- Nov 11, 2014
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Impact of early-stage HIV transmission on treatment as prevention
Kimberly A. Powers, Mirjam E. Kretzschmar, William C. Miller, and Myron S. Cohen

PNAS November 11, 2014 111 (45) 15867-15868; first published November 3, 2014. https://doi.org/10.1073/pnas.1418496111
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Why the proportion of transmission during early-stage HIV infection does not predict the long-term impact of treatment on HIV incidence
- Nov 11, 2014
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Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics
Nimish D. Kathale and Andrew C. Liu

PNAS November 11, 2014 111 (45) 15869-15870; first published November 3, 2014. https://doi.org/10.1073/pnas.1418570111
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A circadian gene expression atlas in mammals: Implications for biology and medicine
- Nov 11, 2014

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS November 11, 2014 111 (45) 15871-15872; https://doi.org/10.1073/pnas.ss11145

Perspective

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The nature of protein folding pathways
S. Walter Englander and Leland Mayne

PNAS November 11, 2014 111 (45) 15873-15880; first published October 17, 2014. https://doi.org/10.1073/pnas.1411798111

Physical Sciences

Applied Mathematics
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  Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
  Ivana Bozic and Martin A. Nowak
  
  PNAS November 11, 2014 111 (45) 15964-15968; first published October 27, 2014. https://doi.org/10.1073/pnas.1412075111
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  Mathematical model of sarcoidosis
  Wenrui Hao, Elliott D. Crouser, and Avner Friedman
  
  PNAS November 11, 2014 111 (45) 16065-16070; first published October 27, 2014. https://doi.org/10.1073/pnas.1417789111
Applied Physical Sciences
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  Understanding shape entropy through local dense packing
  Greg van Anders, Daphne Klotsa, N. Khalid Ahmed, Michael Engel, and Sharon C. Glotzer
  
  PNAS November 11, 2014 111 (45) E4812-E4821; first published October 24, 2014. https://doi.org/10.1073/pnas.1418159111
- Open Access
  Dynamic population mapping using mobile phone data
  Pierre Deville, Catherine Linard, Samuel Martin, Marius Gilbert, Forrest R. Stevens, Andrea E. Gaughan, Vincent D. Blondel, and Andrew J. Tatem
  
  PNAS November 11, 2014 111 (45) 15888-15893; first published October 27, 2014. https://doi.org/10.1073/pnas.1408439111
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  Multiple patterns of polymer gels in microspheres due to the interplay among phase separation, wetting, and gelation
  Miho Yanagisawa, Shinpei Nigorikawa, Takahiro Sakaue, Kei Fujiwara, and Masayuki Tokita
  
  PNAS November 11, 2014 111 (45) 15894-15899; first published October 27, 2014. https://doi.org/10.1073/pnas.1416592111
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  Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels
  Nils R. Blumenthal, Ola Hermanson, Bernd Heimrich, and V. Prasad Shastri
  
  PNAS November 11, 2014 111 (45) 16124-16129; first published October 27, 2014. https://doi.org/10.1073/pnas.1412740111
Chemistry
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  Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila
  Kai Jiang, Yajuan Liu, Junkai Fan, Garretson Epperly, Tianyan Gao, Jin Jiang, and Jianhang Jia
  
  PNAS November 11, 2014 111 (45) E4842-E4850; first published October 27, 2014. https://doi.org/10.1073/pnas.1417147111
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  Luminescence color switching of supramolecular assemblies of discrete molecular decanuclear gold(I) sulfido complexes
  Franky Ka-Wah Hau, Terence Kwok-Ming Lee, Eddie Chung-Chin Cheng, Vonika Ka-Man Au, and Vivian Wing-Wah Yam
  
  PNAS November 11, 2014 111 (45) 15900-15905; first published October 31, 2014. https://doi.org/10.1073/pnas.1418824111
- Open Access
  Self-assembled MmsF proteinosomes control magnetite nanoparticle formation in vitro
  Andrea E. Rawlings, Jonathan P. Bramble, Robyn Walker, Jennifer Bain, Johanna M. Galloway, and Sarah S. Staniland
  
  PNAS November 11, 2014 111 (45) 16094-16099; first published October 27, 2014. https://doi.org/10.1073/pnas.1409256111
Engineering
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  Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain
  Urvashi M. Upadhyay, Betty Tyler, Yoda Patta, Robert Wicks, Kevin Spencer, Alexander Scott, Byron Masi, Lee Hwang, Rachel Grossman, Michael Cima, Henry Brem, and Robert Langer
  
  PNAS November 11, 2014 111 (45) 16071-16076; first published October 27, 2014. https://doi.org/10.1073/pnas.1313420110
Environmental Sciences
- Open Access
  Fallout plume of submerged oil from Deepwater Horizon
  David L. Valentine, G. Burch Fisher, Sarah C. Bagby, Robert K. Nelson, Christopher M. Reddy, Sean P. Sylva, and Mary A. Woo
  
  PNAS November 11, 2014 111 (45) 15906-15911; first published October 27, 2014. https://doi.org/10.1073/pnas.1414873111
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  Vegetation dynamics and rainfall sensitivity of the Amazon
  Thomas Hilker, Alexei I. Lyapustin, Compton J. Tucker, Forrest G. Hall, Ranga B. Myneni, Yujie Wang, Jian Bi, Yhasmin Mendes de Moura, and Piers J. Sellers
  
  PNAS November 11, 2014 111 (45) 16041-16046; first published October 27, 2014. https://doi.org/10.1073/pnas.1404870111
  
  See companion article:
  Reply to Gonsamo et al.: Effect of the Eastern Atlantic-West Russia pattern on Amazon vegetation has not been demonstrated
  - Mar 10, 2015
Physics
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  Scaling laws governing stochastic growth and division of single bacterial cells
  Srividya Iyer-Biswas, Charles S. Wright, Jonathan T. Henry, Klevin Lo, Stanislav Burov, Yihan Lin, Gavin E. Crooks, Sean Crosson, Aaron R. Dinner, and Norbert F. Scherer
  
  PNAS November 11, 2014 111 (45) 15912-15917; first published October 27, 2014. https://doi.org/10.1073/pnas.1403232111
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  Size limits of self-assembled colloidal structures made using specific interactions
  Zorana Zeravcic, Vinothan N. Manoharan, and Michael P. Brenner
  
  PNAS November 11, 2014 111 (45) 15918-15923; first published October 27, 2014. https://doi.org/10.1073/pnas.1411765111

Biological Sciences

Applied Biological Sciences
- Open Access
  Building carbon–carbon bonds using a biocatalytic methanol condensation cycle
  Igor W. Bogorad, Chang-Ting Chen, Matthew K. Theisen, Tung-Yun Wu, Alicia R. Schlenz, Albert T. Lam, and James C. Liao
  
  PNAS November 11, 2014 111 (45) 15928-15933; first published October 29, 2014. https://doi.org/10.1073/pnas.1413470111
- Open Access
  Protease-based synthetic sensing and signal amplification
  Viktor Stein and Kirill Alexandrov
  
  PNAS November 11, 2014 111 (45) 15934-15939; first published October 29, 2014. https://doi.org/10.1073/pnas.1405220111
Biochemistry
- Open Access
  The mechanism of Torsin ATPase activation
  Rebecca S. H. Brown, Chenguang Zhao, Anna R. Chase, Jimin Wang, and Christian Schlieker
  
  PNAS November 11, 2014 111 (45) E4822-E4831; first published October 28, 2014. https://doi.org/10.1073/pnas.1415271111
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  Selective allosteric coupling in core chemotaxis signaling complexes
  Mingshan Li and Gerald L. Hazelbauer
  
  PNAS November 11, 2014 111 (45) 15940-15945; first published October 27, 2014. https://doi.org/10.1073/pnas.1415184111
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  p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation
  Zhihua Tao, Amanda Fusco, De-Bin Huang, Kushol Gupta, Daniel Young Kim, Carl F. Ware, Gregory D. Van Duyne, and Gourisankar Ghosh
  
  PNAS November 11, 2014 111 (45) 15946-15951; first published October 27, 2014. https://doi.org/10.1073/pnas.1408552111
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  Functional conservation despite structural divergence in ligand-responsive RNA switches
  Mark A. Boerneke, Sergey M. Dibrov, Jing Gu, David L. Wyles, and Thomas Hermann
  
  PNAS November 11, 2014 111 (45) 15952-15957; first published October 27, 2014. https://doi.org/10.1073/pnas.1414678111
- Open Access
  The general mode of translation inhibition by macrolide antibiotics
  Krishna Kannan, Pinal Kanabar, David Schryer, Tanja Florin, Eugene Oh, Neil Bahroos, Tanel Tenson, Jonathan S. Weissman, and Alexander S. Mankin
  
  PNAS November 11, 2014 111 (45) 15958-15963; first published October 27, 2014. https://doi.org/10.1073/pnas.1417334111
Biophysics and Computational Biology
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  Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
  Ivana Bozic and Martin A. Nowak
  
  PNAS November 11, 2014 111 (45) 15964-15968; first published October 27, 2014. https://doi.org/10.1073/pnas.1412075111
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  Folding pathway of a multidomain protein depends on its topology of domain connectivity
  From the Cover
  
  Takashi Inanami, Tomoki P. Terada, and Masaki Sasai
  
  PNAS November 11, 2014 111 (45) 15969-15974; first published September 29, 2014. https://doi.org/10.1073/pnas.1406244111
  
  See companion article:
  A simple theoretical model goes a long way in explaining complex behavior in protein folding
  - Nov 11, 2014
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  Benchmarking all-atom simulations using hydrogen exchange
  John J. Skinner, Wookyung Yu, Elizabeth K. Gichana, Michael C. Baxa, James R. Hinshaw, Karl F. Freed, and Tobin R. Sosnick
  
  PNAS November 11, 2014 111 (45) 15975-15980; first published October 27, 2014. https://doi.org/10.1073/pnas.1404213111
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  Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex
  Dmitry Lyumkis, Dario Oliveira dos Passos, Erich B. Tahara, Kristofor Webb, Eric J. Bennett, Staal Vinterbo, Clinton S. Potter, Bridget Carragher, and Claudio A. P. Joazeiro
  
  PNAS November 11, 2014 111 (45) 15981-15986; first published October 27, 2014. https://doi.org/10.1073/pnas.1413882111
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  Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10
  Wei Deng, Sungyun Cho, Pin-Chuan Su, Bryan W. Berger, and Renhao Li
  
  PNAS November 11, 2014 111 (45) 15987-15992; first published October 27, 2014. https://doi.org/10.1073/pnas.1409354111
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  Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease
  Ayşegül Özen, Kuan-Hung Lin, Nese Kurt Yilmaz, and Celia A. Schiffer
  
  PNAS November 11, 2014 111 (45) 15993-15998; first published October 29, 2014. https://doi.org/10.1073/pnas.1414063111
Cell Biology
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  Developing functional musculoskeletal tissues through hypoxia and lysyl oxidase-induced collagen cross-linking
  Eleftherios A. Makris, Donald J. Responte, Nikolaos K. Paschos, Jerry C. Hu, and Kyriacos A. Athanasiou
  
  PNAS November 11, 2014 111 (45) E4832-E4841; first published October 27, 2014. https://doi.org/10.1073/pnas.1414271111
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  Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK
  Hashem A. Dbouk, Lauren M. Weil, G. K. Sachith Perera, Michael T. Dellinger, Gray Pearson, Rolf A. Brekken, and Melanie H. Cobb
  
  PNAS November 11, 2014 111 (45) 15999-16004; first published October 31, 2014. https://doi.org/10.1073/pnas.1419057111
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  Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4–signalosome complex to regulate DNA repair and cell death
  Feng Rao, Jing Xu, A. Basit Khan, Moataz M. Gadalla, Jiyoung Y. Cha, Risheng Xu, Richa Tyagi, Yongjun Dang, Anutosh Chakraborty, and Solomon H. Snyder
  
  PNAS November 11, 2014 111 (45) 16005-16010; first published October 27, 2014. https://doi.org/10.1073/pnas.1417900111
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  Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions
  Yoshikazu Tsukasaki, Naoyuki Miyazaki, Atsushi Matsumoto, Shigenori Nagae, Shigenobu Yonemura, Takuji Tanoue, Kenji Iwasaki, and Masatoshi Takeichi
  
  PNAS November 11, 2014 111 (45) 16011-16016; first published October 29, 2014. https://doi.org/10.1073/pnas.1418990111
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  A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver
  Aditi Sood, Danny Vijey Jeyaraju, Julien Prudent, Alexandre Caron, Philippe Lemieux, Heidi May McBride, Mathieu Laplante, Katalin Tóth, and Luca Pellegrini
  
  PNAS November 11, 2014 111 (45) 16017-16022; first published October 28, 2014. https://doi.org/10.1073/pnas.1408061111
Developmental Biology
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  Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila
  Kai Jiang, Yajuan Liu, Junkai Fan, Garretson Epperly, Tianyan Gao, Jin Jiang, and Jianhang Jia
  
  PNAS November 11, 2014 111 (45) E4842-E4850; first published October 27, 2014. https://doi.org/10.1073/pnas.1417147111
- Open Access
  Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition
  Iva Kronja, Zachary J. Whitfield, Bingbing Yuan, Kristina Dzeyk, Joanna Kirkpatrick, Jeroen Krijgsveld, and Terry L. Orr-Weaver
  
  PNAS November 11, 2014 111 (45) 16023-16028; first published October 27, 2014. https://doi.org/10.1073/pnas.1418657111
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  Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart
  Kory J. Lavine, Slava Epelman, Keita Uchida, Kassandra J. Weber, Colin G. Nichols, Joel D. Schilling, David M. Ornitz, Gwendalyn J. Randolph, and Douglas L. Mann
  
  PNAS November 11, 2014 111 (45) 16029-16034; first published October 27, 2014. https://doi.org/10.1073/pnas.1406508111
Ecology
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  Form of an evolutionary tradeoff affects eco-evolutionary dynamics in a predator–prey system
  From the Cover
  
  Minoru Kasada, Masato Yamamichi, and Takehito Yoshida
  
  PNAS November 11, 2014 111 (45) 16035-16040; first published October 21, 2014. https://doi.org/10.1073/pnas.1406357111
Environmental Sciences
- You have access
  Vegetation dynamics and rainfall sensitivity of the Amazon
  Thomas Hilker, Alexei I. Lyapustin, Compton J. Tucker, Forrest G. Hall, Ranga B. Myneni, Yujie Wang, Jian Bi, Yhasmin Mendes de Moura, and Piers J. Sellers
  
  PNAS November 11, 2014 111 (45) 16041-16046; first published October 27, 2014. https://doi.org/10.1073/pnas.1404870111
  
  See companion article:
  Reply to Gonsamo et al.: Effect of the Eastern Atlantic-West Russia pattern on Amazon vegetation has not been demonstrated
  - Mar 10, 2015
Evolution
- Open Access
  Mating-type switching by chromosomal inversion in methylotrophic yeasts suggests an origin for the three-locus Saccharomyces cerevisiae system
  Sara J. Hanson, Kevin P. Byrne, and Kenneth H. Wolfe
  
  PNAS November 11, 2014 111 (45) E4851-E4858; first published October 27, 2014. https://doi.org/10.1073/pnas.1416014111
- Open Access
  Phylotranscriptomic analysis of the origin and early diversification of land plants
  Norman J. Wickett, Siavash Mirarab, Nam Nguyen, Tandy Warnow, Eric Carpenter, Naim Matasci, Saravanaraj Ayyampalayam, Michael S. Barker, J. Gordon Burleigh, Matthew A. Gitzendanner, Brad R. Ruhfel, Eric Wafula, Joshua P. Der, Sean W. Graham, Sarah Mathews, Michael Melkonian, Douglas E. Soltis, Pamela S. Soltis, Nicholas W. Miles, Carl J. Rothfels, Lisa Pokorny, A. Jonathan Shaw, Lisa DeGironimo, Dennis W. Stevenson, Barbara Surek, Juan Carlos Villarreal, Béatrice Roure, Hervé Philippe, Claude W. dePamphilis, Tao Chen, Michael K. Deyholos, Regina S. Baucom, Toni M. Kutchan, Megan M. Augustin, Jun Wang, Yong Zhang, Zhijian Tian, Zhixiang Yan, Xiaolei Wu, Xiao Sun, Gane Ka-Shu Wong, and James Leebens-Mack
  
  PNAS November 11, 2014 111 (45) E4859-E4868; first published October 29, 2014. https://doi.org/10.1073/pnas.1323926111
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  Algorithms, complexity, and the sciences
  Inaugural Article
  
  Christos Papadimitriou
  
  PNAS November 11, 2014 111 (45) 15881-15887; first published October 27, 2014. https://doi.org/10.1073/pnas.1416954111
  
  See companion article:
  Profile of Christos Papadimitriou
  - Nov 11, 2014
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  Remodeling in bone without osteocytes: Billfish challenge bone structure–function paradigms
  Ayelet Atkins, Mason N. Dean, Maria Laura Habegger, Phillip J. Motta, Lior Ofer, Felix Repp, Anna Shipov, Steve Weiner, John D. Currey, and Ron Shahar
  
  PNAS November 11, 2014 111 (45) 16047-16052; first published October 20, 2014. https://doi.org/10.1073/pnas.1412372111
Immunology and Inflammation
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  Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis
  Kirsten A. Kulcsar, Victoria K. Baxter, Ivorlyne P. Greene, and Diane E. Griffin
  
  PNAS November 11, 2014 111 (45) 16053-16058; first published October 31, 2014. https://doi.org/10.1073/pnas.1418966111
  
  See companion article:
  Going viral and the fatal vulnerability of neurons from immunity, not from infection
  - Dec 02, 2014
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  Human NLRP3 inflammasome senses multiple types of bacterial RNAs
  Wenwen Sha, Hiroki Mitoma, Shino Hanabuchi, Musheng Bao, Leiyun Weng, Naoshi Sugimoto, Ying Liu, Zhiqiang Zhang, Jin Zhong, Bing Sun, and Yong-Jun Liu
  
  PNAS November 11, 2014 111 (45) 16059-16064; first published October 29, 2014. https://doi.org/10.1073/pnas.1412487111
Medical Sciences
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  Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
  Li Tan, Jun Wang, Junko Tanizaki, Zhifeng Huang, Amir R. Aref, Maria Rusan, Su-Jie Zhu, Yiyun Zhang, Dalia Ercan, Rachel G. Liao, Marzia Capelletti, Wenjun Zhou, Wooyoung Hur, NamDoo Kim, Taebo Sim, Suzanne Gaudet, David A. Barbie, Jing-Ruey Joanna Yeh, Cai-Hong Yun, Peter S. Hammerman, Moosa Mohammadi, Pasi A. Jänne, and Nathanael S. Gray
  
  PNAS November 11, 2014 111 (45) E4869-E4877; first published October 27, 2014. https://doi.org/10.1073/pnas.1403438111
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  Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney
  Mohammad R. Ebrahimkhani, Ali Daneshmand, Aprotim Mazumder, Mariacarmela Allocca, Jennifer A. Calvo, Nona Abolhassani, Iny Jhun, Sureshkumar Muthupalani, Cenk Ayata, and Leona D. Samson
  
  PNAS November 11, 2014 111 (45) E4878-E4886; first published October 27, 2014. https://doi.org/10.1073/pnas.1413582111
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  Mathematical model of sarcoidosis
  Wenrui Hao, Elliott D. Crouser, and Avner Friedman
  
  PNAS November 11, 2014 111 (45) 16065-16070; first published October 27, 2014. https://doi.org/10.1073/pnas.1417789111
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  Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain
  Urvashi M. Upadhyay, Betty Tyler, Yoda Patta, Robert Wicks, Kevin Spencer, Alexander Scott, Byron Masi, Lee Hwang, Rachel Grossman, Michael Cima, Henry Brem, and Robert Langer
  
  PNAS November 11, 2014 111 (45) 16071-16076; first published October 27, 2014. https://doi.org/10.1073/pnas.1313420110
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  Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model
  Elisa M. Heber, M. Frederick Hawthorne, Peter J. Kueffer, Marcela A. Garabalino, Silvia I. Thorp, Emiliano C. C. Pozzi, Andrea Monti Hughes, Charles A. Maitz, Satish S. Jalisatgi, David W. Nigg, Paula Curotto, Verónica A. Trivillin, and Amanda E. Schwint
  
  PNAS November 11, 2014 111 (45) 16077-16081; first published October 27, 2014. https://doi.org/10.1073/pnas.1410865111
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  DICER1/Alu RNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration
  Younghee Kim, Valeria Tarallo, Nagaraj Kerur, Tetsuhiro Yasuma, Bradley D. Gelfand, Ana Bastos-Carvalho, Yoshio Hirano, Reo Yasuma, Takeshi Mizutani, Benjamin J. Fowler, Shengjian Li, Hiroki Kaneko, Sasha Bogdanovich, Balamurali K. Ambati, David R. Hinton, William W. Hauswirth, Razqallah Hakem, Charles Wright, and Jayakrishna Ambati
  
  PNAS November 11, 2014 111 (45) 16082-16087; first published October 27, 2014. https://doi.org/10.1073/pnas.1403814111
- Open Access
  DLK1/PREF1 regulates nutrient metabolism and protects from steatosis
  Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B. Pinnock, Sacri R. Ferrón, Antonio Vidal-Puig, and Anne C. Ferguson-Smith
  
  PNAS November 11, 2014 111 (45) 16088-16093; first published October 27, 2014. https://doi.org/10.1073/pnas.1406119111
Microbiology
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  Scaling laws governing stochastic growth and division of single bacterial cells
  Srividya Iyer-Biswas, Charles S. Wright, Jonathan T. Henry, Klevin Lo, Stanislav Burov, Yihan Lin, Gavin E. Crooks, Sean Crosson, Aaron R. Dinner, and Norbert F. Scherer
  
  PNAS November 11, 2014 111 (45) 15912-15917; first published October 27, 2014. https://doi.org/10.1073/pnas.1403232111
- Open Access
  Self-assembled MmsF proteinosomes control magnetite nanoparticle formation in vitro
  Andrea E. Rawlings, Jonathan P. Bramble, Robyn Walker, Jennifer Bain, Johanna M. Galloway, and Sarah S. Staniland
  
  PNAS November 11, 2014 111 (45) 16094-16099; first published October 27, 2014. https://doi.org/10.1073/pnas.1409256111
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  Replication initiator DnaA binds at the Caulobacter centromere and enables chromosome segregation
  Paola E. Mera, Virginia S. Kalogeraki, and Lucy Shapiro
  
  PNAS November 11, 2014 111 (45) 16100-16105; first published October 27, 2014. https://doi.org/10.1073/pnas.1418989111
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  Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice
  Robert H. Yolken, Lorraine Jones-Brando, David D. Dunigan, Geetha Kannan, Faith Dickerson, Emily Severance, Sarven Sabunciyan, C. Conover Talbot Jr., Emese Prandovszky, James R. Gurnon, Irina V. Agarkova, Flora Leister, Kristin L. Gressitt, Ou Chen, Bryan Deuber, Fangrui Ma, Mikhail V. Pletnikov, and James L. Van Etten
  
  PNAS November 11, 2014 111 (45) 16106-16111; first published October 27, 2014. https://doi.org/10.1073/pnas.1418895111
  
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  Reply to Kjartansdóttir et al.: Chlorovirus ATCV-1 findings not explained by contamination
  - Mar 03, 2015
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  Transfer of noncoding DNA drives regulatory rewiring in bacteria
  From the Cover
  
  Cozzarelli Prize Winner
  
  Yaara Oren, Mark B. Smith, Nathan I. Johns, Millie Kaplan Zeevi, Dvora Biran, Eliora Z. Ron, Jukka Corander, Harris H. Wang, Eric J. Alm, and Tal Pupko
  
  PNAS November 11, 2014 111 (45) 16112-16117; first published October 13, 2014. https://doi.org/10.1073/pnas.1413272111
  
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  Horizontal transfer beyond genes
  - Nov 11, 2014
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  Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1–dependent NK cell-mediated lysis of infected cells
  Korneel Grauwet, Claudia Cantoni, Monica Parodi, Andrea De Maria, Bert Devriendt, Daniela Pende, Lorenzo Moretta, Massimo Vitale, and Herman W. Favoreel
  
  PNAS November 11, 2014 111 (45) 16118-16123; first published October 28, 2014. https://doi.org/10.1073/pnas.1409485111
Neuroscience
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  CDK5 activator protein p25 preferentially binds and activates GSK3β
  Hei-Man Chow, Dong Guo, Jie-Chao Zhou, Guan-Yun Zhang, Hui-Fang Li, Karl Herrup, and Jie Zhang
  
  PNAS November 11, 2014 111 (45) E4887-E4895; first published October 20, 2014. https://doi.org/10.1073/pnas.1402627111
- Open Access
  Activity-dependent PI(3,5)P₂ synthesis controls AMPA receptor trafficking during synaptic depression
  Amber J. McCartney, Sergey N. Zolov, Emily J. Kauffman, Yanling Zhang, Bethany S. Strunk, Lois S. Weisman, and Michael A. Sutton
  
  PNAS November 11, 2014 111 (45) E4896-E4905; first published October 29, 2014. https://doi.org/10.1073/pnas.1411117111
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  Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels
  Nils R. Blumenthal, Ola Hermanson, Bernd Heimrich, and V. Prasad Shastri
  
  PNAS November 11, 2014 111 (45) 16124-16129; first published October 27, 2014. https://doi.org/10.1073/pnas.1412740111
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  Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress
  Yayoi Kinoshita, Richard G. Hunter, Jason D. Gray, Roxana Mesias, Bruce S. McEwen, Deanna L. Benson, and D. Stave Kohtz
  
  PNAS November 11, 2014 111 (45) 16130-16135; first published October 27, 2014. https://doi.org/10.1073/pnas.1418896111
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  Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress
  Georgia E. Hodes, Madeline L. Pfau, Marylene Leboeuf, Sam A. Golden, Daniel J. Christoffel, Dana Bregman, Nicole Rebusi, Mitra Heshmati, Hossein Aleyasin, Brandon L. Warren, Benoit Labonté, Sarah Horn, Kyle A. Lapidus, Viktoria Stelzhammer, Erik H. F. Wong, Sabine Bahn, Vaishnav Krishnan, Carlos A. Bolaños-Guzman, James W. Murrough, Miriam Merad, and Scott J. Russo
  
  PNAS November 11, 2014 111 (45) 16136-16141; first published October 20, 2014. https://doi.org/10.1073/pnas.1415191111
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  Sensing nerve injury at the axonal ER: Activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal
  Zhengxin Ying, Vikram Misra, and Valerie M. K. Verge
  
  PNAS November 11, 2014 111 (45) 16142-16147; first published October 27, 2014. https://doi.org/10.1073/pnas.1407462111
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  Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
  Medha M. Pathak, Jamison L. Nourse, Truc Tran, Jennifer Hwe, Janahan Arulmoli, Dai Trang T. Le, Elena Bernardis, Lisa A. Flanagan, and Francesco Tombola
  
  PNAS November 11, 2014 111 (45) 16148-16153; first published October 27, 2014. https://doi.org/10.1073/pnas.1409802111
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  New approach to capture and characterize synaptic proteome
  Xin-An Liu, Beena Kadakkuzha, Bruce Pascal, Caitlin Steckler, Komolitdin Akhmedov, Long Yan, Michael Chalmers, and Sathyanarayanan V. Puthanveettil
  
  PNAS November 11, 2014 111 (45) 16154-16159; first published October 28, 2014. https://doi.org/10.1073/pnas.1401483111
Plant Biology
- Open Access
  Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization
  Tibor Csorba, Julia I. Questa, Qianwen Sun, and Caroline Dean
  
  PNAS November 11, 2014 111 (45) 16160-16165; first published October 27, 2014. https://doi.org/10.1073/pnas.1419030111
- Open Access
  The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes
  Zsuzsanna Mérai, Nina Chumak, Marcelina García-Aguilar, Tzung-Fu Hsieh, Toshiro Nishimura, Vera K. Schoft, János Bindics, Lucyna Ślusarz, Stéphanie Arnoux, Susanne Opravil, Karl Mechtler, Daniel Zilberman, Robert L. Fischer, and Hisashi Tamaru
  
  PNAS November 11, 2014 111 (45) 16166-16171; first published October 24, 2014. https://doi.org/10.1073/pnas.1418564111
- Open Access
  HsfB2b-mediated repression of PRR7 directs abiotic stress responses of the circadian clock
  Elsebeth Kolmos, Brenda Y. Chow, Jose L. Pruneda-Paz, and Steve A. Kay
  
  PNAS November 11, 2014 111 (45) 16172-16177; first published October 28, 2014. https://doi.org/10.1073/pnas.1418483111
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  Use of protein cross-linking and radiolytic footprinting to elucidate PsbP and PsbQ interactions within higher plant Photosystem II
  Manjula P. Mummadisetti, Laurie K. Frankel, Henry D. Bellamy, Larry Sallans, Jost S. Goettert, Michal Brylinski, Patrick A. Limbach, and Terry M. Bricker
  
  PNAS November 11, 2014 111 (45) 16178-16183; first published October 27, 2014. https://doi.org/10.1073/pnas.1415165111
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  A plausible mechanism, based upon SHORT-ROOT movement, for regulating the number of cortex cell layers in roots
  Shuang Wu, Chin-Mei Lee, Tomomi Hayashi, Simara Price, Fanchon Divol, Sophia Henry, Germain Pauluzzi, Christophe Perin, and Kimberly L. Gallagher
  
  PNAS November 11, 2014 111 (45) 16184-16189; first published October 28, 2014. https://doi.org/10.1073/pnas.1407371111
- Open Access
  Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing
  Runlai Hang, Chunyan Liu, Ayaz Ahmad, Yong Zhang, Falong Lu, and Xiaofeng Cao
  
  PNAS November 11, 2014 111 (45) 16190-16195; first published October 28, 2014. https://doi.org/10.1073/pnas.1412697111
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  Nitric oxide negatively regulates AKT1-mediated potassium uptake through modulating vitamin B6 homeostasis in Arabidopsis
  Jinchan Xia, Dongdong Kong, Shaowu Xue, Wang Tian, Nan Li, Fang Bao, Yong Hu, Jing Du, Yu Wang, Xiaojun Pan, Lei Wang, Xiaochen Zhang, Guoqi Niu, Xue Feng, Legong Li, and Yikun He
  
  PNAS November 11, 2014 111 (45) 16196-16201; first published October 29, 2014. https://doi.org/10.1073/pnas.1417473111
Population Biology
- Open Access
  Why the proportion of transmission during early-stage HIV infection does not predict the long-term impact of treatment on HIV incidence
  From the Cover
  
  Jeffrey W. Eaton and Timothy B. Hallett
  
  PNAS November 11, 2014 111 (45) 16202-16207; first published October 13, 2014. https://doi.org/10.1073/pnas.1323007111
  
  See companion article:
  Impact of early-stage HIV transmission on treatment as prevention
  - Nov 11, 2014
Psychological and Cognitive Sciences
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  Unconscious discrimination of social cues from eye whites in infants
  Sarah Jessen and Tobias Grossmann
  
  PNAS November 11, 2014 111 (45) 16208-16213; first published October 27, 2014. https://doi.org/10.1073/pnas.1411333111
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  Unconscious information changes decision accuracy but not confidence
  Alexandra Vlassova, Chris Donkin, and Joel Pearson
  
  PNAS November 11, 2014 111 (45) 16214-16218; first published October 27, 2014. https://doi.org/10.1073/pnas.1403619111
Systems Biology
- Open Access
  A circadian gene expression atlas in mammals: Implications for biology and medicine
  From the Cover
  
  Ray Zhang, Nicholas F. Lahens, Heather I. Ballance, Michael E. Hughes, and John B. Hogenesch
  
  PNAS November 11, 2014 111 (45) 16219-16224; first published October 27, 2014. https://doi.org/10.1073/pnas.1408886111
  
  See companion article:
  Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics
  - Nov 11, 2014

Retraction

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Retraction for Berthier et al., PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1
PNAS November 11, 2014 111 (45) 16225; first published October 20, 2014. https://doi.org/10.1073/pnas.1419354111

Correction

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Correction for Majithia et al., Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
PNAS November 11, 2014 111 (45) 16225; first published October 27, 2014. https://doi.org/10.1073/pnas.1419356111

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