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Table of Contents

November 11, 2014; vol. 111 no. 45

This Week in PNAS

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    In This Issue
    PNAS November 11, 2014 111 (45) 15853-15854; https://doi.org/10.1073/iti4514111

Letters (Online Only)

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    Using multielement isotopic analysis to decipher drought impacts and adaptive management in ancient agricultural systems
    Toby M. Maxwell, Lucas C. R. Silva, and William R. Horwath
    PNAS November 11, 2014 111 (45) E4807-E4808; first published November 3, 2014. https://doi.org/10.1073/pnas.1417618111
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    Reply to Maxwell et al.: Stable isotopes and their potential for interpreting archaeobotanical remains
    Simone Riehl and Konstantin E. Pustovoytov
    PNAS November 11, 2014 111 (45) E4809; first published November 3, 2014. https://doi.org/10.1073/pnas.1418161111

    See companion article:

    • Drought stress in the ancient Near East
      - Aug 11, 2014
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    Not surprisingly, no inheritance of a trait results in no evolution
    Philip W. Hedrick, David W. Coltman, Marco Festa-Bianchet, and Fanie Pelletier
    PNAS November 11, 2014 111 (45) E4810; first published November 3, 2014. https://doi.org/10.1073/pnas.1416665111
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    Reply to Hedrick et al.: Trophy hunting influences the distribution of trait values through demographic impacts
    Lochran W. Traill, Susanne Schindler, and Tim Coulson
    PNAS November 11, 2014 111 (45) E4811; first published November 3, 2014. https://doi.org/10.1073/pnas.1418475111

    See companion article:

    • Demography, not evolution, in bighorn
      - Aug 11, 2014

Opinion

Leading scientists discuss current issues.
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    Opinion: Building a 21st-century infrastructure for the social sciences
    • Front Matter
    Emilio F. Moran, Sandra L. Hofferth, Catherine C. Eckel, Darrick Hamilton, Barbara Entwisle, J. Lawrence Aber, Henry E. Brady, Dalton Conley, Susan L. Cutter, Klaus Hubacek, and John T. Scholz
    PNAS November 11, 2014 111 (45) 15855-15856; https://doi.org/10.1073/pnas.1416561111

Inner Workings

An over-the-shoulder look at scientists at work.
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    Inner Workings: Breaking down bees' dances
    • Front Matter
    Helen H. Shen
    PNAS November 11, 2014 111 (45) 15857; https://doi.org/10.1073/pnas.1417032111

Profile

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    Profile of Christos Papadimitriou
    Farooq Ahmed
    PNAS November 11, 2014 111 (45) 15858-15860; first published October 27, 2014. https://doi.org/10.1073/pnas.1405579111

    See companion article:

    • Algorithms, complexity, and the sciences
      - Oct 27, 2014

Commentaries

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    Closing the sea level budget at the Last Glacial Maximum
    Peter U. Clark and Lev Tarasov
    PNAS November 11, 2014 111 (45) 15861-15862; first published November 3, 2014. https://doi.org/10.1073/pnas.1418970111

    See companion article:

    • Sea level and ice volume since the glacial maximum
      - Oct 13, 2014
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    A simple theoretical model goes a long way in explaining complex behavior in protein folding
    Victor Muñoz
    PNAS November 11, 2014 111 (45) 15863-15864; first published October 27, 2014. https://doi.org/10.1073/pnas.1418039111

    See companion article:

    • Folding pathway of a multidomain protein
      - Sep 29, 2014
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    Horizontal transfer beyond genes
    Eugene V. Koonin
    PNAS November 11, 2014 111 (45) 15865-15866; first published October 30, 2014. https://doi.org/10.1073/pnas.1418789111

    See companion article:

    • Bacterial regulatory switching
      - Oct 13, 2014
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    Impact of early-stage HIV transmission on treatment as prevention
    Kimberly A. Powers, Mirjam E. Kretzschmar, William C. Miller, and Myron S. Cohen
    PNAS November 11, 2014 111 (45) 15867-15868; first published November 3, 2014. https://doi.org/10.1073/pnas.1418496111

    See companion article:

    • Early transmission and HIV treatment as prevention
      - Oct 13, 2014
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    Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics
    Nimish D. Kathale and Andrew C. Liu
    PNAS November 11, 2014 111 (45) 15869-15870; first published November 3, 2014. https://doi.org/10.1073/pnas.1418570111

    See companion article:

    • A circadian gene expression atlas in mammals
      - Oct 27, 2014

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.
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    PNAS Plus Significance Statements
    PNAS November 11, 2014 111 (45) 15871-15872; https://doi.org/10.1073/pnas.ss11145

Perspective

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    The nature of protein folding pathways
    S. Walter Englander and Leland Mayne
    PNAS November 11, 2014 111 (45) 15873-15880; first published October 17, 2014. https://doi.org/10.1073/pnas.1411798111

Physical Sciences

  • Applied Mathematics

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      Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
      Ivana Bozic and Martin A. Nowak
      PNAS November 11, 2014 111 (45) 15964-15968; first published October 27, 2014. https://doi.org/10.1073/pnas.1412075111
    • You have access
      Mathematical model of sarcoidosis
      Wenrui Hao, Elliott D. Crouser, and Avner Friedman
      PNAS November 11, 2014 111 (45) 16065-16070; first published October 27, 2014. https://doi.org/10.1073/pnas.1417789111
  • Applied Physical Sciences

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      Understanding shape entropy through local dense packing
      Greg van Anders, Daphne Klotsa, N. Khalid Ahmed, Michael Engel, and Sharon C. Glotzer
      PNAS November 11, 2014 111 (45) E4812-E4821; first published October 24, 2014. https://doi.org/10.1073/pnas.1418159111
    • Open Access
      Dynamic population mapping using mobile phone data
      Pierre Deville, Catherine Linard, Samuel Martin, Marius Gilbert, Forrest R. Stevens, Andrea E. Gaughan, Vincent D. Blondel, and Andrew J. Tatem
      PNAS November 11, 2014 111 (45) 15888-15893; first published October 27, 2014. https://doi.org/10.1073/pnas.1408439111
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      Multiple patterns of polymer gels in microspheres due to the interplay among phase separation, wetting, and gelation
      Miho Yanagisawa, Shinpei Nigorikawa, Takahiro Sakaue, Kei Fujiwara, and Masayuki Tokita
      PNAS November 11, 2014 111 (45) 15894-15899; first published October 27, 2014. https://doi.org/10.1073/pnas.1416592111
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      Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels
      Nils R. Blumenthal, Ola Hermanson, Bernd Heimrich, and V. Prasad Shastri
      PNAS November 11, 2014 111 (45) 16124-16129; first published October 27, 2014. https://doi.org/10.1073/pnas.1412740111
  • Chemistry

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      Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila
      Kai Jiang, Yajuan Liu, Junkai Fan, Garretson Epperly, Tianyan Gao, Jin Jiang, and Jianhang Jia
      PNAS November 11, 2014 111 (45) E4842-E4850; first published October 27, 2014. https://doi.org/10.1073/pnas.1417147111
    • You have access
      Luminescence color switching of supramolecular assemblies of discrete molecular decanuclear gold(I) sulfido complexes
      Franky Ka-Wah Hau, Terence Kwok-Ming Lee, Eddie Chung-Chin Cheng, Vonika Ka-Man Au, and Vivian Wing-Wah Yam
      PNAS November 11, 2014 111 (45) 15900-15905; first published October 31, 2014. https://doi.org/10.1073/pnas.1418824111
    • Open Access
      Self-assembled MmsF proteinosomes control magnetite nanoparticle formation in vitro
      Andrea E. Rawlings, Jonathan P. Bramble, Robyn Walker, Jennifer Bain, Johanna M. Galloway, and Sarah S. Staniland
      PNAS November 11, 2014 111 (45) 16094-16099; first published October 27, 2014. https://doi.org/10.1073/pnas.1409256111
  • Engineering

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      Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain
      Urvashi M. Upadhyay, Betty Tyler, Yoda Patta, Robert Wicks, Kevin Spencer, Alexander Scott, Byron Masi, Lee Hwang, Rachel Grossman, Michael Cima, Henry Brem, and Robert Langer
      PNAS November 11, 2014 111 (45) 16071-16076; first published October 27, 2014. https://doi.org/10.1073/pnas.1313420110
  • Environmental Sciences

    • Open Access
      Fallout plume of submerged oil from Deepwater Horizon
      David L. Valentine, G. Burch Fisher, Sarah C. Bagby, Robert K. Nelson, Christopher M. Reddy, Sean P. Sylva, and Mary A. Woo
      PNAS November 11, 2014 111 (45) 15906-15911; first published October 27, 2014. https://doi.org/10.1073/pnas.1414873111
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      Vegetation dynamics and rainfall sensitivity of the Amazon
      Thomas Hilker, Alexei I. Lyapustin, Compton J. Tucker, Forrest G. Hall, Ranga B. Myneni, Yujie Wang, Jian Bi, Yhasmin Mendes de Moura, and Piers J. Sellers
      PNAS November 11, 2014 111 (45) 16041-16046; first published October 27, 2014. https://doi.org/10.1073/pnas.1404870111

      See companion article:

      • Effect of EA-WR on Amazon productivity is unknown
        - Feb 20, 2015
  • Physics

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      Scaling laws governing stochastic growth and division of single bacterial cells
      Srividya Iyer-Biswas, Charles S. Wright, Jonathan T. Henry, Klevin Lo, Stanislav Burov, Yihan Lin, Gavin E. Crooks, Sean Crosson, Aaron R. Dinner, and Norbert F. Scherer
      PNAS November 11, 2014 111 (45) 15912-15917; first published October 27, 2014. https://doi.org/10.1073/pnas.1403232111
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      Size limits of self-assembled colloidal structures made using specific interactions
      Zorana Zeravcic, Vinothan N. Manoharan, and Michael P. Brenner
      PNAS November 11, 2014 111 (45) 15918-15923; first published October 27, 2014. https://doi.org/10.1073/pnas.1411765111

Social Sciences

  • Economic Sciences

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      Algorithms, complexity, and the sciences
      • Inaugural Article
      Christos Papadimitriou
      PNAS November 11, 2014 111 (45) 15881-15887; first published October 27, 2014. https://doi.org/10.1073/pnas.1416954111

      See companion article:

      • Profile of Christos Papadimitriou
        - Oct 27, 2014
    • You have access
      Direct and indirect punishment among strangers in the field
      Loukas Balafoutas, Nikos Nikiforakis, and Bettina Rockenbach
      PNAS November 11, 2014 111 (45) 15924-15927; first published October 27, 2014. https://doi.org/10.1073/pnas.1413170111
  • Environmental Sciences

    • Open Access
      Dynamic population mapping using mobile phone data
      Pierre Deville, Catherine Linard, Samuel Martin, Marius Gilbert, Forrest R. Stevens, Andrea E. Gaughan, Vincent D. Blondel, and Andrew J. Tatem
      PNAS November 11, 2014 111 (45) 15888-15893; first published October 27, 2014. https://doi.org/10.1073/pnas.1408439111

Biological Sciences

  • Applied Biological Sciences

    • Open Access
      Building carbon–carbon bonds using a biocatalytic methanol condensation cycle
      Igor W. Bogorad, Chang-Ting Chen, Matthew K. Theisen, Tung-Yun Wu, Alicia R. Schlenz, Albert T. Lam, and James C. Liao
      PNAS November 11, 2014 111 (45) 15928-15933; first published October 29, 2014. https://doi.org/10.1073/pnas.1413470111
    • Open Access
      Protease-based synthetic sensing and signal amplification
      Viktor Stein and Kirill Alexandrov
      PNAS November 11, 2014 111 (45) 15934-15939; first published October 29, 2014. https://doi.org/10.1073/pnas.1405220111
  • Biochemistry

    • Open Access
      The mechanism of Torsin ATPase activation
      Rebecca S. H. Brown, Chenguang Zhao, Anna R. Chase, Jimin Wang, and Christian Schlieker
      PNAS November 11, 2014 111 (45) E4822-E4831; first published October 28, 2014. https://doi.org/10.1073/pnas.1415271111
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      Selective allosteric coupling in core chemotaxis signaling complexes
      Mingshan Li and Gerald L. Hazelbauer
      PNAS November 11, 2014 111 (45) 15940-15945; first published October 27, 2014. https://doi.org/10.1073/pnas.1415184111
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      p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation
      Zhihua Tao, Amanda Fusco, De-Bin Huang, Kushol Gupta, Daniel Young Kim, Carl F. Ware, Gregory D. Van Duyne, and Gourisankar Ghosh
      PNAS November 11, 2014 111 (45) 15946-15951; first published October 27, 2014. https://doi.org/10.1073/pnas.1408552111
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      Functional conservation despite structural divergence in ligand-responsive RNA switches
      Mark A. Boerneke, Sergey M. Dibrov, Jing Gu, David L. Wyles, and Thomas Hermann
      PNAS November 11, 2014 111 (45) 15952-15957; first published October 27, 2014. https://doi.org/10.1073/pnas.1414678111
    • Open Access
      The general mode of translation inhibition by macrolide antibiotics
      Krishna Kannan, Pinal Kanabar, David Schryer, Tanja Florin, Eugene Oh, Neil Bahroos, Tanel Tenson, Jonathan S. Weissman, and Alexander S. Mankin
      PNAS November 11, 2014 111 (45) 15958-15963; first published October 27, 2014. https://doi.org/10.1073/pnas.1417334111
  • Biophysics and Computational Biology

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      Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
      Ivana Bozic and Martin A. Nowak
      PNAS November 11, 2014 111 (45) 15964-15968; first published October 27, 2014. https://doi.org/10.1073/pnas.1412075111
    • You have access
      Folding pathway of a multidomain protein depends on its topology of domain connectivity
      • From the Cover
      Takashi Inanami, Tomoki P. Terada, and Masaki Sasai
      PNAS November 11, 2014 111 (45) 15969-15974; first published September 29, 2014. https://doi.org/10.1073/pnas.1406244111

      See companion article:

      • Explaining complex behavior in protein folding
        - Oct 27, 2014
    • You have access
      Benchmarking all-atom simulations using hydrogen exchange
      John J. Skinner, Wookyung Yu, Elizabeth K. Gichana, Michael C. Baxa, James R. Hinshaw, Karl F. Freed, and Tobin R. Sosnick
      PNAS November 11, 2014 111 (45) 15975-15980; first published October 27, 2014. https://doi.org/10.1073/pnas.1404213111
    • You have access
      Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex
      Dmitry Lyumkis, Dario Oliveira dos Passos, Erich B. Tahara, Kristofor Webb, Eric J. Bennett, Staal Vinterbo, Clinton S. Potter, Bridget Carragher, and Claudio A. P. Joazeiro
      PNAS November 11, 2014 111 (45) 15981-15986; first published October 27, 2014. https://doi.org/10.1073/pnas.1413882111
    • You have access
      Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10
      Wei Deng, Sungyun Cho, Pin-Chuan Su, Bryan W. Berger, and Renhao Li
      PNAS November 11, 2014 111 (45) 15987-15992; first published October 27, 2014. https://doi.org/10.1073/pnas.1409354111
    • You have access
      Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease
      Ayşegül Özen, Kuan-Hung Lin, Nese Kurt Yilmaz, and Celia A. Schiffer
      PNAS November 11, 2014 111 (45) 15993-15998; first published October 29, 2014. https://doi.org/10.1073/pnas.1414063111
  • Cell Biology

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      Developing functional musculoskeletal tissues through hypoxia and lysyl oxidase-induced collagen cross-linking
      Eleftherios A. Makris, Donald J. Responte, Nikolaos K. Paschos, Jerry C. Hu, and Kyriacos A. Athanasiou
      PNAS November 11, 2014 111 (45) E4832-E4841; first published October 27, 2014. https://doi.org/10.1073/pnas.1414271111
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      Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK
      Hashem A. Dbouk, Lauren M. Weil, G. K. Sachith Perera, Michael T. Dellinger, Gray Pearson, Rolf A. Brekken, and Melanie H. Cobb
      PNAS November 11, 2014 111 (45) 15999-16004; first published October 31, 2014. https://doi.org/10.1073/pnas.1419057111
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      Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4–signalosome complex to regulate DNA repair and cell death
      Feng Rao, Jing Xu, A. Basit Khan, Moataz M. Gadalla, Jiyoung Y. Cha, Risheng Xu, Richa Tyagi, Yongjun Dang, Anutosh Chakraborty, and Solomon H. Snyder
      PNAS November 11, 2014 111 (45) 16005-16010; first published October 27, 2014. https://doi.org/10.1073/pnas.1417900111
    • You have access
      Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions
      Yoshikazu Tsukasaki, Naoyuki Miyazaki, Atsushi Matsumoto, Shigenori Nagae, Shigenobu Yonemura, Takuji Tanoue, Kenji Iwasaki, and Masatoshi Takeichi
      PNAS November 11, 2014 111 (45) 16011-16016; first published October 29, 2014. https://doi.org/10.1073/pnas.1418990111
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      A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver
      Aditi Sood, Danny Vijey Jeyaraju, Julien Prudent, Alexandre Caron, Philippe Lemieux, Heidi May McBride, Mathieu Laplante, Katalin Tóth, and Luca Pellegrini
      PNAS November 11, 2014 111 (45) 16017-16022; first published October 28, 2014. https://doi.org/10.1073/pnas.1408061111
  • Developmental Biology

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      Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila
      Kai Jiang, Yajuan Liu, Junkai Fan, Garretson Epperly, Tianyan Gao, Jin Jiang, and Jianhang Jia
      PNAS November 11, 2014 111 (45) E4842-E4850; first published October 27, 2014. https://doi.org/10.1073/pnas.1417147111
    • Open Access
      Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition
      Iva Kronja, Zachary J. Whitfield, Bingbing Yuan, Kristina Dzeyk, Joanna Kirkpatrick, Jeroen Krijgsveld, and Terry L. Orr-Weaver
      PNAS November 11, 2014 111 (45) 16023-16028; first published October 27, 2014. https://doi.org/10.1073/pnas.1418657111
    • You have access
      Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart
      Kory J. Lavine, Slava Epelman, Keita Uchida, Kassandra J. Weber, Colin G. Nichols, Joel D. Schilling, David M. Ornitz, Gwendalyn J. Randolph, and Douglas L. Mann
      PNAS November 11, 2014 111 (45) 16029-16034; first published October 27, 2014. https://doi.org/10.1073/pnas.1406508111
  • Ecology

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      Form of an evolutionary tradeoff affects eco-evolutionary dynamics in a predator–prey system
      • From the Cover
      Minoru Kasada, Masato Yamamichi, and Takehito Yoshida
      PNAS November 11, 2014 111 (45) 16035-16040; first published October 21, 2014. https://doi.org/10.1073/pnas.1406357111
  • Environmental Sciences

    • You have access
      Vegetation dynamics and rainfall sensitivity of the Amazon
      Thomas Hilker, Alexei I. Lyapustin, Compton J. Tucker, Forrest G. Hall, Ranga B. Myneni, Yujie Wang, Jian Bi, Yhasmin Mendes de Moura, and Piers J. Sellers
      PNAS November 11, 2014 111 (45) 16041-16046; first published October 27, 2014. https://doi.org/10.1073/pnas.1404870111

      See companion article:

      • Effect of EA-WR on Amazon productivity is unknown
        - Feb 20, 2015
  • Evolution

    • Open Access
      Mating-type switching by chromosomal inversion in methylotrophic yeasts suggests an origin for the three-locus Saccharomyces cerevisiae system
      Sara J. Hanson, Kevin P. Byrne, and Kenneth H. Wolfe
      PNAS November 11, 2014 111 (45) E4851-E4858; first published October 27, 2014. https://doi.org/10.1073/pnas.1416014111
    • Open Access
      Phylotranscriptomic analysis of the origin and early diversification of land plants
      Norman J. Wickett, Siavash Mirarab, Nam Nguyen, Tandy Warnow, Eric Carpenter, Naim Matasci, Saravanaraj Ayyampalayam, Michael S. Barker, J. Gordon Burleigh, Matthew A. Gitzendanner, Brad R. Ruhfel, Eric Wafula, Joshua P. Der, Sean W. Graham, Sarah Mathews, Michael Melkonian, Douglas E. Soltis, Pamela S. Soltis, Nicholas W. Miles, Carl J. Rothfels, Lisa Pokorny, A. Jonathan Shaw, Lisa DeGironimo, Dennis W. Stevenson, Barbara Surek, Juan Carlos Villarreal, Béatrice Roure, Hervé Philippe, Claude W. dePamphilis, Tao Chen, Michael K. Deyholos, Regina S. Baucom, Toni M. Kutchan, Megan M. Augustin, Jun Wang, Yong Zhang, Zhijian Tian, Zhixiang Yan, Xiaolei Wu, Xiao Sun, Gane Ka-Shu Wong, and James Leebens-Mack
      PNAS November 11, 2014 111 (45) E4859-E4868; first published October 29, 2014. https://doi.org/10.1073/pnas.1323926111
    • You have access
      Algorithms, complexity, and the sciences
      • Inaugural Article
      Christos Papadimitriou
      PNAS November 11, 2014 111 (45) 15881-15887; first published October 27, 2014. https://doi.org/10.1073/pnas.1416954111

      See companion article:

      • Profile of Christos Papadimitriou
        - Oct 27, 2014
    • You have access
      Remodeling in bone without osteocytes: Billfish challenge bone structure–function paradigms
      Ayelet Atkins, Mason N. Dean, Maria Laura Habegger, Phillip J. Motta, Lior Ofer, Felix Repp, Anna Shipov, Steve Weiner, John D. Currey, and Ron Shahar
      PNAS November 11, 2014 111 (45) 16047-16052; first published October 20, 2014. https://doi.org/10.1073/pnas.1412372111
  • Immunology and Inflammation

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      Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis
      Kirsten A. Kulcsar, Victoria K. Baxter, Ivorlyne P. Greene, and Diane E. Griffin
      PNAS November 11, 2014 111 (45) 16053-16058; first published October 31, 2014. https://doi.org/10.1073/pnas.1418966111

      See companion article:

      • Going viral and the fatal vulnerability of neurons
        - Nov 24, 2014
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      Human NLRP3 inflammasome senses multiple types of bacterial RNAs
      Wenwen Sha, Hiroki Mitoma, Shino Hanabuchi, Musheng Bao, Leiyun Weng, Naoshi Sugimoto, Ying Liu, Zhiqiang Zhang, Jin Zhong, Bing Sun, and Yong-Jun Liu
      PNAS November 11, 2014 111 (45) 16059-16064; first published October 29, 2014. https://doi.org/10.1073/pnas.1412487111
  • Medical Sciences

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      Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
      Li Tan, Jun Wang, Junko Tanizaki, Zhifeng Huang, Amir R. Aref, Maria Rusan, Su-Jie Zhu, Yiyun Zhang, Dalia Ercan, Rachel G. Liao, Marzia Capelletti, Wenjun Zhou, Wooyoung Hur, NamDoo Kim, Taebo Sim, Suzanne Gaudet, David A. Barbie, Jing-Ruey Joanna Yeh, Cai-Hong Yun, Peter S. Hammerman, Moosa Mohammadi, Pasi A. Jänne, and Nathanael S. Gray
      PNAS November 11, 2014 111 (45) E4869-E4877; first published October 27, 2014. https://doi.org/10.1073/pnas.1403438111
    • You have access
      Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney
      Mohammad R. Ebrahimkhani, Ali Daneshmand, Aprotim Mazumder, Mariacarmela Allocca, Jennifer A. Calvo, Nona Abolhassani, Iny Jhun, Sureshkumar Muthupalani, Cenk Ayata, and Leona D. Samson
      PNAS November 11, 2014 111 (45) E4878-E4886; first published October 27, 2014. https://doi.org/10.1073/pnas.1413582111
    • You have access
      Mathematical model of sarcoidosis
      Wenrui Hao, Elliott D. Crouser, and Avner Friedman
      PNAS November 11, 2014 111 (45) 16065-16070; first published October 27, 2014. https://doi.org/10.1073/pnas.1417789111
    • You have access
      Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain
      Urvashi M. Upadhyay, Betty Tyler, Yoda Patta, Robert Wicks, Kevin Spencer, Alexander Scott, Byron Masi, Lee Hwang, Rachel Grossman, Michael Cima, Henry Brem, and Robert Langer
      PNAS November 11, 2014 111 (45) 16071-16076; first published October 27, 2014. https://doi.org/10.1073/pnas.1313420110
    • You have access
      Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model
      Elisa M. Heber, M. Frederick Hawthorne, Peter J. Kueffer, Marcela A. Garabalino, Silvia I. Thorp, Emiliano C. C. Pozzi, Andrea Monti Hughes, Charles A. Maitz, Satish S. Jalisatgi, David W. Nigg, Paula Curotto, Verónica A. Trivillin, and Amanda E. Schwint
      PNAS November 11, 2014 111 (45) 16077-16081; first published October 27, 2014. https://doi.org/10.1073/pnas.1410865111
    • You have access
      DICER1/Alu RNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration
      Younghee Kim, Valeria Tarallo, Nagaraj Kerur, Tetsuhiro Yasuma, Bradley D. Gelfand, Ana Bastos-Carvalho, Yoshio Hirano, Reo Yasuma, Takeshi Mizutani, Benjamin J. Fowler, Shengjian Li, Hiroki Kaneko, Sasha Bogdanovich, Balamurali K. Ambati, David R. Hinton, William W. Hauswirth, Razqallah Hakem, Charles Wright, and Jayakrishna Ambati
      PNAS November 11, 2014 111 (45) 16082-16087; first published October 27, 2014. https://doi.org/10.1073/pnas.1403814111
    • Open Access
      DLK1/PREF1 regulates nutrient metabolism and protects from steatosis
      Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B. Pinnock, Sacri R. Ferrón, Antonio Vidal-Puig, and Anne C. Ferguson-Smith
      PNAS November 11, 2014 111 (45) 16088-16093; first published October 27, 2014. https://doi.org/10.1073/pnas.1406119111
  • Microbiology

    • You have access
      Scaling laws governing stochastic growth and division of single bacterial cells
      Srividya Iyer-Biswas, Charles S. Wright, Jonathan T. Henry, Klevin Lo, Stanislav Burov, Yihan Lin, Gavin E. Crooks, Sean Crosson, Aaron R. Dinner, and Norbert F. Scherer
      PNAS November 11, 2014 111 (45) 15912-15917; first published October 27, 2014. https://doi.org/10.1073/pnas.1403232111
    • Open Access
      Self-assembled MmsF proteinosomes control magnetite nanoparticle formation in vitro
      Andrea E. Rawlings, Jonathan P. Bramble, Robyn Walker, Jennifer Bain, Johanna M. Galloway, and Sarah S. Staniland
      PNAS November 11, 2014 111 (45) 16094-16099; first published October 27, 2014. https://doi.org/10.1073/pnas.1409256111
    • You have access
      Replication initiator DnaA binds at the Caulobacter centromere and enables chromosome segregation
      Paola E. Mera, Virginia S. Kalogeraki, and Lucy Shapiro
      PNAS November 11, 2014 111 (45) 16100-16105; first published October 27, 2014. https://doi.org/10.1073/pnas.1418989111
    • You have access
      Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice
      Robert H. Yolken, Lorraine Jones-Brando, David D. Dunigan, Geetha Kannan, Faith Dickerson, Emily Severance, Sarven Sabunciyan, C. Conover Talbot Jr., Emese Prandovszky, James R. Gurnon, Irina V. Agarkova, Flora Leister, Kristin L. Gressitt, Ou Chen, Bryan Deuber, Fangrui Ma, Mikhail V. Pletnikov, and James L. Van Etten
      PNAS November 11, 2014 111 (45) 16106-16111; first published October 27, 2014. https://doi.org/10.1073/pnas.1418895111

      See companion article:

      • Virus ATCV-1 findings not explained by contamination
        - Feb 05, 2015
    • You have access
      Transfer of noncoding DNA drives regulatory rewiring in bacteria
      • From the Cover
      • Cozzarelli Prize Winner
      Yaara Oren, Mark B. Smith, Nathan I. Johns, Millie Kaplan Zeevi, Dvora Biran, Eliora Z. Ron, Jukka Corander, Harris H. Wang, Eric J. Alm, and Tal Pupko
      PNAS November 11, 2014 111 (45) 16112-16117; first published October 13, 2014. https://doi.org/10.1073/pnas.1413272111

      See companion article:

      • Horizontal regulatory transfer
        - Oct 30, 2014
    • You have access
      Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1–dependent NK cell-mediated lysis of infected cells
      Korneel Grauwet, Claudia Cantoni, Monica Parodi, Andrea De Maria, Bert Devriendt, Daniela Pende, Lorenzo Moretta, Massimo Vitale, and Herman W. Favoreel
      PNAS November 11, 2014 111 (45) 16118-16123; first published October 28, 2014. https://doi.org/10.1073/pnas.1409485111
  • Neuroscience

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      CDK5 activator protein p25 preferentially binds and activates GSK3β
      Hei-Man Chow, Dong Guo, Jie-Chao Zhou, Guan-Yun Zhang, Hui-Fang Li, Karl Herrup, and Jie Zhang
      PNAS November 11, 2014 111 (45) E4887-E4895; first published October 20, 2014. https://doi.org/10.1073/pnas.1402627111
    • Open Access
      Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression
      Amber J. McCartney, Sergey N. Zolov, Emily J. Kauffman, Yanling Zhang, Bethany S. Strunk, Lois S. Weisman, and Michael A. Sutton
      PNAS November 11, 2014 111 (45) E4896-E4905; first published October 29, 2014. https://doi.org/10.1073/pnas.1411117111
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      Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels
      Nils R. Blumenthal, Ola Hermanson, Bernd Heimrich, and V. Prasad Shastri
      PNAS November 11, 2014 111 (45) 16124-16129; first published October 27, 2014. https://doi.org/10.1073/pnas.1412740111
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      Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress
      Yayoi Kinoshita, Richard G. Hunter, Jason D. Gray, Roxana Mesias, Bruce S. McEwen, Deanna L. Benson, and D. Stave Kohtz
      PNAS November 11, 2014 111 (45) 16130-16135; first published October 27, 2014. https://doi.org/10.1073/pnas.1418896111
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      Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress
      Georgia E. Hodes, Madeline L. Pfau, Marylene Leboeuf, Sam A. Golden, Daniel J. Christoffel, Dana Bregman, Nicole Rebusi, Mitra Heshmati, Hossein Aleyasin, Brandon L. Warren, Benoit Labonté, Sarah Horn, Kyle A. Lapidus, Viktoria Stelzhammer, Erik H. F. Wong, Sabine Bahn, Vaishnav Krishnan, Carlos A. Bolaños-Guzman, James W. Murrough, Miriam Merad, and Scott J. Russo
      PNAS November 11, 2014 111 (45) 16136-16141; first published October 20, 2014. https://doi.org/10.1073/pnas.1415191111
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      Sensing nerve injury at the axonal ER: Activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal
      Zhengxin Ying, Vikram Misra, and Valerie M. K. Verge
      PNAS November 11, 2014 111 (45) 16142-16147; first published October 27, 2014. https://doi.org/10.1073/pnas.1407462111
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      Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
      Medha M. Pathak, Jamison L. Nourse, Truc Tran, Jennifer Hwe, Janahan Arulmoli, Dai Trang T. Le, Elena Bernardis, Lisa A. Flanagan, and Francesco Tombola
      PNAS November 11, 2014 111 (45) 16148-16153; first published October 27, 2014. https://doi.org/10.1073/pnas.1409802111
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      New approach to capture and characterize synaptic proteome
      Xin-An Liu, Beena Kadakkuzha, Bruce Pascal, Caitlin Steckler, Komolitdin Akhmedov, Long Yan, Michael Chalmers, and Sathyanarayanan V. Puthanveettil
      PNAS November 11, 2014 111 (45) 16154-16159; first published October 28, 2014. https://doi.org/10.1073/pnas.1401483111
  • Plant Biology

    • Open Access
      Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization
      Tibor Csorba, Julia I. Questa, Qianwen Sun, and Caroline Dean
      PNAS November 11, 2014 111 (45) 16160-16165; first published October 27, 2014. https://doi.org/10.1073/pnas.1419030111
    • Open Access
      The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes
      Zsuzsanna Mérai, Nina Chumak, Marcelina García-Aguilar, Tzung-Fu Hsieh, Toshiro Nishimura, Vera K. Schoft, János Bindics, Lucyna Ślusarz, Stéphanie Arnoux, Susanne Opravil, Karl Mechtler, Daniel Zilberman, Robert L. Fischer, and Hisashi Tamaru
      PNAS November 11, 2014 111 (45) 16166-16171; first published October 24, 2014. https://doi.org/10.1073/pnas.1418564111
    • Open Access
      HsfB2b-mediated repression of PRR7 directs abiotic stress responses of the circadian clock
      Elsebeth Kolmos, Brenda Y. Chow, Jose L. Pruneda-Paz, and Steve A. Kay
      PNAS November 11, 2014 111 (45) 16172-16177; first published October 28, 2014. https://doi.org/10.1073/pnas.1418483111
    • You have access
      Use of protein cross-linking and radiolytic footprinting to elucidate PsbP and PsbQ interactions within higher plant Photosystem II
      Manjula P. Mummadisetti, Laurie K. Frankel, Henry D. Bellamy, Larry Sallans, Jost S. Goettert, Michal Brylinski, Patrick A. Limbach, and Terry M. Bricker
      PNAS November 11, 2014 111 (45) 16178-16183; first published October 27, 2014. https://doi.org/10.1073/pnas.1415165111
    • You have access
      A plausible mechanism, based upon SHORT-ROOT movement, for regulating the number of cortex cell layers in roots
      Shuang Wu, Chin-Mei Lee, Tomomi Hayashi, Simara Price, Fanchon Divol, Sophia Henry, Germain Pauluzzi, Christophe Perin, and Kimberly L. Gallagher
      PNAS November 11, 2014 111 (45) 16184-16189; first published October 28, 2014. https://doi.org/10.1073/pnas.1407371111
    • Open Access
      Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing
      Runlai Hang, Chunyan Liu, Ayaz Ahmad, Yong Zhang, Falong Lu, and Xiaofeng Cao
      PNAS November 11, 2014 111 (45) 16190-16195; first published October 28, 2014. https://doi.org/10.1073/pnas.1412697111
    • You have access
      Nitric oxide negatively regulates AKT1-mediated potassium uptake through modulating vitamin B6 homeostasis in Arabidopsis
      Jinchan Xia, Dongdong Kong, Shaowu Xue, Wang Tian, Nan Li, Fang Bao, Yong Hu, Jing Du, Yu Wang, Xiaojun Pan, Lei Wang, Xiaochen Zhang, Guoqi Niu, Xue Feng, Legong Li, and Yikun He
      PNAS November 11, 2014 111 (45) 16196-16201; first published October 29, 2014. https://doi.org/10.1073/pnas.1417473111
  • Population Biology

    • Open Access
      Why the proportion of transmission during early-stage HIV infection does not predict the long-term impact of treatment on HIV incidence
      • From the Cover
      Jeffrey W. Eaton and Timothy B. Hallett
      PNAS November 11, 2014 111 (45) 16202-16207; first published October 13, 2014. https://doi.org/10.1073/pnas.1323007111

      See companion article:

      • Early HIV and treatment as prevention
        - Nov 03, 2014
  • Psychological and Cognitive Sciences

    • You have access
      Unconscious discrimination of social cues from eye whites in infants
      Sarah Jessen and Tobias Grossmann
      PNAS November 11, 2014 111 (45) 16208-16213; first published October 27, 2014. https://doi.org/10.1073/pnas.1411333111
    • You have access
      Unconscious information changes decision accuracy but not confidence
      Alexandra Vlassova, Chris Donkin, and Joel Pearson
      PNAS November 11, 2014 111 (45) 16214-16218; first published October 27, 2014. https://doi.org/10.1073/pnas.1403619111
  • Systems Biology

    • Open Access
      A circadian gene expression atlas in mammals: Implications for biology and medicine
      • From the Cover
      Ray Zhang, Nicholas F. Lahens, Heather I. Ballance, Michael E. Hughes, and John B. Hogenesch
      PNAS November 11, 2014 111 (45) 16219-16224; first published October 27, 2014. https://doi.org/10.1073/pnas.1408886111

      See companion article:

      • Circadian Gene Atlas
        - Nov 03, 2014

Retraction

  • You have access
    Retraction for Berthier et al., PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1
    PNAS November 11, 2014 111 (45) 16225; first published October 20, 2014. https://doi.org/10.1073/pnas.1419354111

Correction

  • You have access
    Correction for Majithia et al., Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
    PNAS November 11, 2014 111 (45) 16225; first published October 27, 2014. https://doi.org/10.1073/pnas.1419356111
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Proceedings of the National Academy of Sciences: 111 (45)
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