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Evolutionary cell biology: Two origins, one objective

Michael Lynch, Mark C. Field, Holly V. Goodson, Harmit S. Malik, José B. Pereira-Leal, David S. Roos, Aaron P. Turkewitz, and Shelley Sazer
PNAS December 2, 2014 111 (48) 16990-16994; first published November 17, 2014; https://doi.org/10.1073/pnas.1415861111
Michael Lynch
aDepartment of Biology, Indiana University, Bloomington, IN 47405;
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  • For correspondence: milynch@indiana.edu ssazer@bcm.edu
Mark C. Field
bDivision of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, United Kingdom;
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Holly V. Goodson
cDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556;
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Harmit S. Malik
dDivision of Basic Sciences and
eHoward Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98195;
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José B. Pereira-Leal
fInstituto Gulbenkian de Ciência, P-2781-901 Oeiras, Portugal;
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David S. Roos
gDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19143;
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Aaron P. Turkewitz
hDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637; and
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Shelley Sazer
iVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030
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  • For correspondence: milynch@indiana.edu ssazer@bcm.edu
  1. Edited by W. Ford Doolittle, Dalhousie University, Halifax, NS, Canada, and approved October 20, 2014 (received for review September 3, 2014)

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    Fig. 1.

    Taxonomic distribution of research articles and sequenced genomes. Modern taxonomy identifies five major eukaryotic supergroups: the Excavates (turquoise), Chromalveolates (orange), Archaeplastida (green), Amoebozoa (purple), and Opisthokonts (red). Although the total number of species on earth remains unknown, it is clear that there are far more unicellular eukaryotes than the combined total of all animals (Metazoa, an Opisthokont lineage), fungi (also Opisthokonts), and plants (Archaeplastida). However, research activity displays considerable taxonomic bias. As of January 2014, the National Center for Biotechnology Information taxonomy browser (www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi) lists 338 Archaeal genomes (dark gray), 20,709 Eubacteria (light gray), 769 Metazoa, 1,201 Fungi, 251 green plants/algae, and 336 genomes from all other eukaryotic taxa (13% of eukaryotic genomes). The taxonomic distribution of PubMed citations is as follows: Archaea, 19,000; Eubacteria, 397,000; Metazoa, 576,000; Fungi, 135,000; green plants/algae, 168,000; and all other eukaryotes combined, 97,000 (<9% of publications on Eukaryotes).

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Evolutionary cell biology
Michael Lynch, Mark C. Field, Holly V. Goodson, Harmit S. Malik, José B. Pereira-Leal, David S. Roos, Aaron P. Turkewitz, Shelley Sazer
Proceedings of the National Academy of Sciences Dec 2014, 111 (48) 16990-16994; DOI: 10.1073/pnas.1415861111

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Evolutionary cell biology
Michael Lynch, Mark C. Field, Holly V. Goodson, Harmit S. Malik, José B. Pereira-Leal, David S. Roos, Aaron P. Turkewitz, Shelley Sazer
Proceedings of the National Academy of Sciences Dec 2014, 111 (48) 16990-16994; DOI: 10.1073/pnas.1415861111
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Proceedings of the National Academy of Sciences: 111 (48)
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    • Why Are Cells the Way They Are, and Why Aren’t They Perfect?
    • How Do Cellular Innovations Arise?
    • Where Do Cellular Innovations Map onto the Tree of Life?
    • How Can Effective Implementation of Lessons from Evolutionary Cell Biology Be Ensured?
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