Despite myriad challenges, clinicians see room for progress.
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Contributed by Maria I. New, November 11, 2014 (sent for review October 2, 2014; reviewed by Wafik El-Deiry and H. Michael Shepard)
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- Published in issue December 16, 2014.
- Published first December 1, 2014.
Author Information
- Agnes Stachnika,1,
- Tony Yuena,1,
- Jameel Iqbala,
- Miriam Sgobbab,
- Yogesh Guptaa,
- Ping Lua,
- Graziana Colaiannia,c,
- Yaoting Jia,d,
- Ling-Ling Zhua,d,
- Se-Min Kima,
- Jianhua Lia,
- Peng Liua,
- Sudeh Izadmehra,
- Jaya Sangodkara,
- Thomas Scherera,
- Shiraz Mujtabaa,
- Matthew Galskya,
- Jorge Gomeza,
- Solomon Epsteina,
- Christoph Buettnera,
- Zhuan Biand,
- Alberta Zallonec,
- Aneel K. Aggarwala,
- Shozeb Haiderb,
- Maria I. Newa,2,
- Li Suna,3,
- Goutham Narlaa,e,3, and
- Mone Zaidia,2,3
- aDepartments of Medicine, Pediatrics, and Chemical and Structural Biology, and the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;
- bDepartment of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College, London WC1N 1AX, United Kingdom;
- cDepartment of Histology, University of Bari, Bari 70121, Italy;
- dDepartment of Research, School of Stomatology, Wuhan University, Wuhan 430079, China; and
- eDepartment of Medicine and Institute for Transformative Molecular Medicine, Case Western Reserve University, Cleveland, OH 44106
Contributed by Maria I. New, November 11, 2014 (sent for review October 2, 2014; reviewed by Wafik El-Deiry and H. Michael Shepard)
Footnotes
↵1A.S. and T.Y. contributed equally to this work.
- ↵2To whom correspondence may be addressed. Email: maria.new{at}mssm.edu or mone.zaidi{at}mountsinai.org.
↵3L.S., G.N., and M.Z. contributed equally to this work.
Author contributions: T.Y., A.K.A., S.H., M.I.N., L.S., G.N., and M.Z. designed research; A.S., T.Y., J.I., M.S., Y.G., P. Lu, G.C., Y.J., L.-L.Z., S.-M.K., J.L., S.I., J.S., T.S., and L.S. performed research; A.S., T.Y., J.I., M.S., Y.G., P. Lu, G.C., S.-M.K., P. Liu, S.I., S.M., M.G., J.G., S.E., C.B., Z.B., A.Z., A.K.A., S.H., L.S., G.N., and M.Z. analyzed data; and A.S., T.Y., M.I.N., G.N., and M.Z. wrote the paper.
Reviewers: W.E.-D., Fox Chase Cancer Center; and H.M.S., Halozyme Therapeutics, Inc.
Conflict of interest statement: M.Z., J.I., and G.N. are named inventors of a pending patent application related to the work described.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1421422111/-/DCSupplemental.
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