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Research Article

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

Luke Whitesell, Sandro Santagata, Marc L. Mendillo, Nancy U. Lin, David A. Proia, and Susan Lindquist
PNAS December 23, 2014 111 (51) 18297-18302; first published December 8, 2014; https://doi.org/10.1073/pnas.1421323111
Luke Whitesell
aWhitehead Institute for Biomedical Research, Cambridge, MA 02142;
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  • For correspondence: lindquist_admin@wi.mit.edu whitesell@wi.mit.edu
Sandro Santagata
aWhitehead Institute for Biomedical Research, Cambridge, MA 02142;
bDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115;
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Marc L. Mendillo
aWhitehead Institute for Biomedical Research, Cambridge, MA 02142;
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Nancy U. Lin
cDepartment of Medical Oncology, Dana–Farber Cancer Institute, Boston, MA 02215;
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David A. Proia
dSynta Pharmaceuticals, Lexington, MA 02421;
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Susan Lindquist
aWhitehead Institute for Biomedical Research, Cambridge, MA 02142;
eDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142; and
fHoward Hughes Medical Institute, Cambridge, MA 02142
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  • For correspondence: lindquist_admin@wi.mit.edu whitesell@wi.mit.edu
  1. Contributed by Susan Lindquist, November 7, 2014 (sent for review August 13, 2014)

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Article Information

vol. 111 no. 51 18297-18302
DOI: 
https://doi.org/10.1073/pnas.1421323111
PubMed: 
25489079

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue December 23, 2014.
  • Published first December 8, 2014.


Author Information

  1. Luke Whitesella,1,
  2. Sandro Santagataa,b,
  3. Marc L. Mendilloa,
  4. Nancy U. Linc,
  5. David A. Proiad, and
  6. Susan Lindquista,e,f,1
  1. aWhitehead Institute for Biomedical Research, Cambridge, MA 02142;
  2. bDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115;
  3. cDepartment of Medical Oncology, Dana–Farber Cancer Institute, Boston, MA 02215;
  4. dSynta Pharmaceuticals, Lexington, MA 02421;
  5. eDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142; and
  6. fHoward Hughes Medical Institute, Cambridge, MA 02142
  1. Contributed by Susan Lindquist, November 7, 2014 (sent for review August 13, 2014)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: lindquist_admin{at}wi.mit.edu or whitesell{at}wi.mit.edu.
  • Author contributions: L.W., S.S., and S.L. designed research; L.W., S.S., and D.A.P. performed research; L.W., S.S., M.L.M., and N.U.L. analyzed data; N.U.L. and D.A.P. reviewed findings and provided advice; and L.W. and S.L. wrote the paper.

  • Conflict of interest statement: D.A.P. is an employee of Synta Pharmaceuticals, and M.L.M. holds an equity interest in the company.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1421323111/-/DCSupplemental.

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HSP90 empowers evolution of hormone resistance
Luke Whitesell, Sandro Santagata, Marc L. Mendillo, Nancy U. Lin, David A. Proia, Susan Lindquist
Proceedings of the National Academy of Sciences Dec 2014, 111 (51) 18297-18302; DOI: 10.1073/pnas.1421323111

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HSP90 empowers evolution of hormone resistance
Luke Whitesell, Sandro Santagata, Marc L. Mendillo, Nancy U. Lin, David A. Proia, Susan Lindquist
Proceedings of the National Academy of Sciences Dec 2014, 111 (51) 18297-18302; DOI: 10.1073/pnas.1421323111
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Hazards of ozone pollution to birds
Amanda Rodewald, Ivan Rudik, and Catherine Kling talk about the hazards of ozone pollution to birds.
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Transplantation of sperm-producing stem cells
CRISPR-Cas9 gene editing can improve the effectiveness of spermatogonial stem cell transplantation in mice and livestock, a study finds.
Image credit: Jon M. Oatley.

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