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HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models
Contributed by Susan Lindquist, November 7, 2014 (sent for review August 13, 2014)

Online Impact
Article Information
- Published in issue December 23, 2014.
- Published first December 8, 2014.
Author Information
- Luke Whitesella,1,
- Sandro Santagataa,b,
- Marc L. Mendilloa,
- Nancy U. Linc,
- David A. Proiad, and
- Susan Lindquista,e,f,1
- aWhitehead Institute for Biomedical Research, Cambridge, MA 02142;
- bDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115;
- cDepartment of Medical Oncology, Dana–Farber Cancer Institute, Boston, MA 02215;
- dSynta Pharmaceuticals, Lexington, MA 02421;
- eDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142; and
- fHoward Hughes Medical Institute, Cambridge, MA 02142
Contributed by Susan Lindquist, November 7, 2014 (sent for review August 13, 2014)
Footnotes
- ↵1To whom correspondence may be addressed. Email: lindquist_admin{at}wi.mit.edu or whitesell{at}wi.mit.edu.
Author contributions: L.W., S.S., and S.L. designed research; L.W., S.S., and D.A.P. performed research; L.W., S.S., M.L.M., and N.U.L. analyzed data; N.U.L. and D.A.P. reviewed findings and provided advice; and L.W. and S.L. wrote the paper.
Conflict of interest statement: D.A.P. is an employee of Synta Pharmaceuticals, and M.L.M. holds an equity interest in the company.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1421323111/-/DCSupplemental.
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