The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

Departments of ^aImmunobiology and
^bPathology, Yale University School of Medicine, New Haven, CT 06520;
^cDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany; and
^dHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520

Contributed by Ruslan Medzhitov, December 3, 2013 (sent for review October 13, 2013)

Footnotes

↵¹To whom correspondence should be addressed. E-mail: ruslan.medzhitov{at}yale.edu.

Author contributions: P.V.C. and R.M. designed research; P.V.C. performed research; S.O. contributed new reagents/analytic tools; P.V.C., L.H., and R.M. analyzed data; and P.V.C. and R.M. wrote the paper.
The authors declare no conflict of interest.
See Commentary on page 2058.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1322269111/-/DCSupplemental.

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Total 2020	1699	2537	1598
Jan 2021	69	235	145
Total 2021	69	235	145
Total	26107	10707	13899