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Table of Contents
March 17, 2015; vol. 112 no. 11
This Week in PNAS
PNAS 100th Anniversary Article
Commentary
- You have accessHubble’s Law and the expanding universeNeta A. Bahcall
See companion article:
- Hubble's quarter century in orbit- Mar 17, 2015
Letters (Online Only)
- You have accessBig changes before big birthdays? Panel data provide no evidence of end-of-decade crisesSimon Kühne, Thorsten Schneider, and David RichterPNAS March 17, 2015 112 (11) E1170; first published February 18, 2015. https://doi.org/10.1073/pnas.1424903112
- You have accessReply to Kühne et al.: Still good evidence that people search for meaning when they approach a new decade in chronological ageAdam L. Alter and Hal E. HershfieldPNAS March 17, 2015 112 (11) E1171; first published February 18, 2015. https://doi.org/10.1073/pnas.1500787112
See companion article:
- New decades in age and the search for meaning- Nov 17, 2014
- You have accessTitin ruler hypothesis not refutedLarissa Tskhovrebova, Pauline Bennett, Mathias Gautel, and John TrinickPNAS March 17, 2015 112 (11) E1172; first published February 18, 2015. https://doi.org/10.1073/pnas.1422326112
- You have accessReply to Tskhovrebova et al.: Titin’s IA junction does not control thick filament lengthHenk L. GranzierPNAS March 17, 2015 112 (11) E1173; first published February 18, 2015. https://doi.org/10.1073/pnas.1500871112
See companion article:
- Titin's role in muscle structure and function- Sep 22, 2014
Inner Workings
An over-the-shoulder look at scientists at work.
- You have accessInner Workings: Hubble’s quarter century in orbit has opened a universe of possibilities
- Front Matter
David J. HarrisSee companion article:
- Hubble's Law and the expanding universe- Mar 17, 2015
PNAS Plus Significance Statements
Brief statements written by the authors about the significance of their papers.
Physical Sciences
Applied Physical Sciences
- Open AccessPolytypism, polymorphism, and superconductivity in TaSe2−xTexHuixia Luo, Weiwei Xie, Jing Tao, Hiroyuki Inoue, András Gyenis, Jason W. Krizan, Ali Yazdani, Yimei Zhu, and Robert Joseph CavaPNAS March 17, 2015 112 (11) E1174-E1180; first published March 3, 2015. https://doi.org/10.1073/pnas.1502460112
- Open AccessNucleation of metastable aragonite CaCO3 in seawaterWenhao Sun, Saivenkataraman Jayaraman, Wei Chen, Kristin A. Persson, and Gerbrand CederPNAS March 17, 2015 112 (11) 3199-3204; first published March 4, 2015. https://doi.org/10.1073/pnas.1423898112
Chemistry
- Open AccessDe novo production of the plant-derived alkaloid strictosidine in yeastStephanie Brown, Marc Clastre, Vincent Courdavault, and Sarah E. O’ConnorPNAS March 17, 2015 112 (11) 3205-3210; first published February 9, 2015. https://doi.org/10.1073/pnas.1423555112
- You have accessGlutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cellsYifan Hong, Yau-Tsz Lai, Godfrey Chi-Fung Chan, and Hongzhe SunPNAS March 17, 2015 112 (11) 3211-3216; first published March 3, 2015. https://doi.org/10.1073/pnas.1421002112
See companion article:
- Systems pharmacology for metallodrugs- Mar 30, 2015
- You have accessSpray-combustion synthesis: Efficient solution route to high-performance oxide transistors
- From the Cover
Xinge Yu, Jeremy Smith, Nanjia Zhou, Li Zeng, Peijun Guo, Yu Xia, Ana Alvarez, Stefano Aghion, Hui Lin, Junsheng Yu, Robert P. H. Chang, Michael J. Bedzyk, Rafael Ferragut, Tobin J. Marks, and Antonio FacchettiPNAS March 17, 2015 112 (11) 3217-3222; first published March 2, 2015. https://doi.org/10.1073/pnas.1501548112 - You have accessStructure of superhard tungsten tetraboride: A missing link between MB2 and MB12 higher boridesAndrew T. Lech, Christopher L. Turner, Reza Mohammadi, Sarah H. Tolbert, and Richard B. KanerPNAS March 17, 2015 112 (11) 3223-3228; first published March 2, 2015. https://doi.org/10.1073/pnas.1415018112
- You have accessTwo-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicityChunte Sam Peng, Bogdan I. Fedeles, Vipender Singh, Deyu Li, Tiffany Amariuta, John M. Essigmann, and Andrei TokmakoffPNAS March 17, 2015 112 (11) 3229-3234; first published March 2, 2015. https://doi.org/10.1073/pnas.1415974112
- You have accessLocating landmarks on high-dimensional free energy surfacesMing Chen, Tang-Qing Yu, and Mark E. TuckermanPNAS March 17, 2015 112 (11) 3235-3240; first published March 3, 2015. https://doi.org/10.1073/pnas.1418241112
Earth, Atmospheric, and Planetary Sciences
- You have accessClimate change in the Fertile Crescent and implications of the recent Syrian droughtColin P. Kelley, Shahrzad Mohtadi, Mark A. Cane, Richard Seager, and Yochanan KushnirPNAS March 17, 2015 112 (11) 3241-3246; first published March 2, 2015. https://doi.org/10.1073/pnas.1421533112
- Open AccessVapor hydrogen and oxygen isotopes reflect water of combustion in the urban atmosphereGalen Gorski, Courtenay Strong, Stephen P. Good, Ryan Bares, James R. Ehleringer, and Gabriel J. BowenPNAS March 17, 2015 112 (11) 3247-3252; first published March 2, 2015. https://doi.org/10.1073/pnas.1424728112
- Open AccessDynamical evidence for causality between galactic cosmic rays and interannual variation in global temperatureAnastasios A. Tsonis, Ethan R. Deyle, Robert M. May, George Sugihara, Kyle Swanson, Joshua D. Verbeten, and Geli WangPNAS March 17, 2015 112 (11) 3253-3256; first published March 2, 2015. https://doi.org/10.1073/pnas.1420291112
See companion article:
- Causal effects of cosmic rays on temperature- Aug 17, 2015
- Open AccessEffects of large-scale deforestation on precipitation in the monsoon regions: Remote versus local effectsN. Devaraju, Govindasamy Bala, and Angshuman ModakPNAS March 17, 2015 112 (11) 3257-3262; first published March 2, 2015. https://doi.org/10.1073/pnas.1423439112
- Open AccessOcean-driven thinning enhances iceberg calving and retreat of Antarctic ice shelvesYan Liu, John C. Moore, Xiao Cheng, Rupert M. Gladstone, Jeremy N. Bassis, Hongxing Liu, Jiahong Wen, and Fengming HuiPNAS March 17, 2015 112 (11) 3263-3268; first published March 2, 2015. https://doi.org/10.1073/pnas.1415137112
Engineering
- You have accessImplantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistanceJoão Conde, Nuria Oliva, and Natalie ArtziPNAS March 17, 2015 112 (11) E1278-E1287; first published March 2, 2015. https://doi.org/10.1073/pnas.1421229112
- You have accessQuorum-sensing Salmonella selectively trigger protein expression within tumorsCharles A. Swofford, Nele Van Dessel, and Neil S. ForbesPNAS March 17, 2015 112 (11) 3457-3462; first published March 3, 2015. https://doi.org/10.1073/pnas.1414558112
Physics
- You have accessn-type thermoelectric material Mg2Sn0.75Ge0.25 for high power generationWeishu Liu, Hee Seok Kim, Shuo Chen, Qing Jie, Bing Lv, Mengliang Yao, Zhensong Ren, Cyril P. Opeil, Stephen Wilson, Ching-Wu Chu, and Zhifeng RenPNAS March 17, 2015 112 (11) 3269-3274; first published March 2, 2015. https://doi.org/10.1073/pnas.1424388112
- You have accessThe second laws of quantum thermodynamicsFernando Brandão, Michał Horodecki, Nelly Ng, Jonathan Oppenheim, and Stephanie WehnerPNAS March 17, 2015 112 (11) 3275-3279; first published February 9, 2015. https://doi.org/10.1073/pnas.1411728112
- You have accessKelvin–Helmholtz instability in an ultrathin air film causes drop splashing on smooth surfacesYuan Liu, Peng Tan, and Lei XuPNAS March 17, 2015 112 (11) 3280-3284; first published February 23, 2015. https://doi.org/10.1073/pnas.1417718112
- You have accessAvoided valence transition in a plutonium superconductorB. J. Ramshaw, Arkady Shekhter, Ross D. McDonald, Jon B. Betts, J. N. Mitchell, P. H. Tobash, C. H. Mielke, E. D. Bauer, and Albert MiglioriPNAS March 17, 2015 112 (11) 3285-3289; first published March 3, 2015. https://doi.org/10.1073/pnas.1421174112
- Open AccessDynamical phase transition in the open Dicke modelJens Klinder, Hans Keßler, Matthias Wolke, Ludwig Mathey, and Andreas HemmerichPNAS March 17, 2015 112 (11) 3290-3295; first published March 2, 2015. https://doi.org/10.1073/pnas.1417132112
Social Sciences
Anthropology
- You have accessCore questions in domestication research
- Inaugural Article
Melinda A. ZederPNAS March 17, 2015 112 (11) 3191-3198; first published February 20, 2015. https://doi.org/10.1073/pnas.1501711112See companion article:
- Profile of Melinda A. Zeder- Apr 06, 2015
See companion article:
- Human behavioral ecology needs a rethink- Jun 01, 2015
- You have accessImpacts of biological globalization in the Mediterranean: Unveiling the deep history of human-mediated gamebird dispersalGiovanni Forcina, Monica Guerrini, Hein van Grouw, Brij K. Gupta, Panicos Panayides, Pantelis Hadjigerou, Omar F. Al-Sheikhly, Muhammad N. Awan, Aleem A. Khan, Melinda A. Zeder, and Filippo BarbaneraPNAS March 17, 2015 112 (11) 3296-3301; first published March 2, 2015. https://doi.org/10.1073/pnas.1500677112
- You have accessEvidence for recent, population-specific evolution of the human mutation rateKelley HarrisPNAS March 17, 2015 112 (11) 3439-3444; first published March 2, 2015. https://doi.org/10.1073/pnas.1418652112
Environmental Sciences
- You have accessClimate change in the Fertile Crescent and implications of the recent Syrian droughtColin P. Kelley, Shahrzad Mohtadi, Mark A. Cane, Richard Seager, and Yochanan KushnirPNAS March 17, 2015 112 (11) 3241-3246; first published March 2, 2015. https://doi.org/10.1073/pnas.1421533112
- Open AccessVapor hydrogen and oxygen isotopes reflect water of combustion in the urban atmosphereGalen Gorski, Courtenay Strong, Stephen P. Good, Ryan Bares, James R. Ehleringer, and Gabriel J. BowenPNAS March 17, 2015 112 (11) 3247-3252; first published March 2, 2015. https://doi.org/10.1073/pnas.1424728112
Political Sciences
- You have accessPrepregnancy body mass and weight gain during pregnancy in India and sub-Saharan AfricaDiane CoffeyPNAS March 17, 2015 112 (11) 3302-3307; first published March 2, 2015. https://doi.org/10.1073/pnas.1416964112
Psychological and Cognitive Sciences
- You have accessDisruption of hierarchical predictive coding during sleepMelanie Strauss, Jacobo D. Sitt, Jean-Remi King, Maxime Elbaz, Leila Azizi, Marco Buiatti, Lionel Naccache, Virginie van Wassenhove, and Stanislas DehaenePNAS March 17, 2015 112 (11) E1353-E1362; first published March 3, 2015. https://doi.org/10.1073/pnas.1501026112
- Open AccessEpigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brainMeghan H. Puglia, Travis S. Lillard, James P. Morris, and Jessica J. ConnellyPNAS March 17, 2015 112 (11) 3308-3313; first published February 9, 2015. https://doi.org/10.1073/pnas.1422096112
- You have accessIncreasing propensity to mind-wander with transcranial direct current stimulation
- From the Cover
Vadim Axelrod, Geraint Rees, Michal Lavidor, and Moshe BarPNAS March 17, 2015 112 (11) 3314-3319; first published February 17, 2015. https://doi.org/10.1073/pnas.1421435112See companion article:
- Stimulating minds to wander- Mar 09, 2015
Biological Sciences
Applied Biological Sciences
- You have accessAntigen specificity can be irrelevant to immunocytokine efficacy and biodistributionAlice Tzeng, Byron H. Kwan, Cary F. Opel, Tejas Navaratna, and K. Dane WittrupPNAS March 17, 2015 112 (11) 3320-3325; first published March 2, 2015. https://doi.org/10.1073/pnas.1416159112
Biochemistry
- You have accessComprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solutionMatthias Hillenbrand, Christian Schori, Jendrik Schöppe, and Andreas PlückthunPNAS March 17, 2015 112 (11) E1181-E1190; first published March 2, 2015. https://doi.org/10.1073/pnas.1417573112
- You have accessDramatically reduced spliceosome in Cyanidioschyzon merolaeMartha R. Stark, Elizabeth A. Dunn, William S. C. Dunn, Cameron J. Grisdale, Anthony R. Daniele, Matthew R. G. Halstead, Naomi M. Fast, and Stephen D. RaderPNAS March 17, 2015 112 (11) E1191-E1200; first published March 2, 2015. https://doi.org/10.1073/pnas.1416879112
- Open AccessMyosin VI deafness mutation prevents the initiation of processive runs on actinOlena Pylypenko, Lin Song, Ai Shima, Zhaohui Yang, Anne M. Houdusse, and H. Lee SweeneyPNAS March 17, 2015 112 (11) E1201-E1209; first published March 6, 2015. https://doi.org/10.1073/pnas.1420989112
- Open AccessDe novo production of the plant-derived alkaloid strictosidine in yeastStephanie Brown, Marc Clastre, Vincent Courdavault, and Sarah E. O’ConnorPNAS March 17, 2015 112 (11) 3205-3210; first published February 9, 2015. https://doi.org/10.1073/pnas.1423555112
- You have accessSteric clashes with bound OMP peptides activate the DegS stress-response proteaseAnna K. de Regt, Tania A. Baker, and Robert T. SauerPNAS March 17, 2015 112 (11) 3326-3331; first published March 2, 2015. https://doi.org/10.1073/pnas.1502372112
- You have accessFunctional analysis of (4S)-limonene synthase mutants reveals determinants of catalytic outcome in a model monoterpene synthaseNarayanan Srividya, Edward M. Davis, Rodney B. Croteau, and B. Markus LangePNAS March 17, 2015 112 (11) 3332-3337; first published March 2, 2015. https://doi.org/10.1073/pnas.1501203112
- You have accessRationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivoTsz-Leung To, Beverly J. Piggott, Kalpana Makhijani, Dan Yu, Yuh Nung Jan, and Xiaokun ShuPNAS March 17, 2015 112 (11) 3338-3343; first published March 2, 2015. https://doi.org/10.1073/pnas.1502857112
- Open AccessCleavage of amyloid precursor protein by an archaeal presenilin homologue PSHShangyu Dang, Shenjie Wu, Jiawei Wang, Hongbo Li, Min Huang, Wei He, Yue-Ming Li, Catherine C. L. Wong, and Yigong ShiPNAS March 17, 2015 112 (11) 3344-3349; first published March 2, 2015. https://doi.org/10.1073/pnas.1502150112
- You have accessAtg13 HORMA domain recruits Atg9 vesicles during autophagosome formationSho W. Suzuki, Hayashi Yamamoto, Yu Oikawa, Chika Kondo-Kakuta, Yayoi Kimura, Hisashi Hirano, and Yoshinori OhsumiPNAS March 17, 2015 112 (11) 3350-3355; first published March 3, 2015. https://doi.org/10.1073/pnas.1421092112
- Open AccessPlasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporterNarinobu Juge, Sawako Moriyama, Takaaki Miyaji, Mamiyo Kawakami, Haruka Iwai, Tomoya Fukui, Nathan Nelson, Hiroshi Omote, and Yoshinori MoriyamaPNAS March 17, 2015 112 (11) 3356-3361; first published March 2, 2015. https://doi.org/10.1073/pnas.1417102112
Biophysics and Computational Biology
- Open AccessSalient features of otoacoustic emissions are common across tetrapod groups and suggest shared properties of generation mechanismsChristopher Bergevin, Geoffrey A. Manley, and Christine KöpplPNAS March 17, 2015 112 (11) 3362-3367; first published March 3, 2015. https://doi.org/10.1073/pnas.1418569112
- You have accessElectron crystallography of ultrathin 3D protein crystals: Atomic model with chargesKoji Yonekura, Kazuyuki Kato, Mitsuo Ogasawara, Masahiro Tomita, and Chikashi ToyoshimaPNAS March 17, 2015 112 (11) 3368-3373; first published February 17, 2015. https://doi.org/10.1073/pnas.1500724112
- You have accessConformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopyLalit Deshmukh, Rodolfo Ghirlando, and G. Marius ClorePNAS March 17, 2015 112 (11) 3374-3379; first published February 23, 2015. https://doi.org/10.1073/pnas.1501985112
- You have accessNanomechanics and intermolecular forces of amyloid revealed by four-dimensional electron microscopyAnthony W. P. Fitzpatrick, Giovanni M. Vanacore, and Ahmed H. ZewailPNAS March 17, 2015 112 (11) 3380-3385; first published March 2, 2015. https://doi.org/10.1073/pnas.1502214112
- You have accessL596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channelJinfeng Teng, Stephen H. Loukin, Andriy Anishkin, and Ching KungPNAS March 17, 2015 112 (11) 3386-3391; first published March 3, 2015. https://doi.org/10.1073/pnas.1502366112
- You have accessPigeons trade efficiency for stability in response to level of challenge during confined flightC. David Williams and Andrew A. BiewenerPNAS March 17, 2015 112 (11) 3392-3396; first published March 2, 2015. https://doi.org/10.1073/pnas.1407298112
- You have accessMutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump siteChristoph von Ballmoos, Nathalie Gonska, Peter Lachmann, Robert B. Gennis, Pia Ädelroth, and Peter BrzezinskiPNAS March 17, 2015 112 (11) 3397-3402; first published March 2, 2015. https://doi.org/10.1073/pnas.1422434112
- You have accessCation-induced kinetic heterogeneity of the intron–exon recognition in single group II intronsDanny Kowerko, Sebastian L. B. König, Miriam Skilandat, Daniela Kruschel, Mélodie C. A. S. Hadzic, Lucia Cardo, and Roland K. O. SigelPNAS March 17, 2015 112 (11) 3403-3408; first published March 3, 2015. https://doi.org/10.1073/pnas.1322759112
- You have accessStructure and dynamics of the MKK7–JNK signaling complexJaka Kragelj, Andrés Palencia, Max H. Nanao, Damien Maurin, Guillaume Bouvignies, Martin Blackledge, and Malene Ringkjøbing JensenPNAS March 17, 2015 112 (11) 3409-3414; first published March 3, 2015. https://doi.org/10.1073/pnas.1419528112
Cell Biology
- You have accessBRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1Chunmin Ge, Lixiao Che, Jinyu Ren, Raj K. Pandita, Jing Lu, Kaiyi Li, Tej K. Pandita, and Chunying DuPNAS March 17, 2015 112 (11) E1210-E1219; first published March 2, 2015. https://doi.org/10.1073/pnas.1418335112
- Open AccessProteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4Alla Polotskaia, Gu Xiao, Katherine Reynoso, Che Martin, Wei-Gang Qiu, Ronald C. Hendrickson, and Jill BargonettiPNAS March 17, 2015 112 (11) E1220-E1229; first published March 2, 2015. https://doi.org/10.1073/pnas.1416318112
- You have accessEndocannabinoids are conserved inhibitors of the Hedgehog pathwayHelena Khaliullina, Mesut Bilgin, Julio L. Sampaio, Andrej Shevchenko, and Suzanne EatonPNAS March 17, 2015 112 (11) 3415-3420; first published March 2, 2015. https://doi.org/10.1073/pnas.1416463112
- You have accessGenomically amplified Akt3 activates DNA repair pathway and promotes glioma progressionKristen M. Turner, Youting Sun, Ping Ji, Kirsi J. Granberg, Brady Bernard, Limei Hu, David E. Cogdell, Xinhui Zhou, Olli Yli-Harja, Matti Nykter, Ilya Shmulevich, W. K. Alfred Yung, Gregory N. Fuller, and Wei ZhangPNAS March 17, 2015 112 (11) 3421-3426; first published March 3, 2015. https://doi.org/10.1073/pnas.1414573112
Ecology
- Open AccessHadal biosphere: Insight into the microbial ecosystem in the deepest ocean on EarthTakuro Nunoura, Yoshihiro Takaki, Miho Hirai, Shigeru Shimamura, Akiko Makabe, Osamu Koide, Tohru Kikuchi, Junichi Miyazaki, Keisuke Koba, Naohiro Yoshida, Michinari Sunamura, and Ken TakaiPNAS March 17, 2015 112 (11) E1230-E1236; first published February 23, 2015. https://doi.org/10.1073/pnas.1421816112
- You have accessRapid behavioral maturation accelerates failure of stressed honey bee colonies
- From the Cover
Clint J. Perry, Eirik Søvik, Mary R. Myerscough, and Andrew B. BarronPNAS March 17, 2015 112 (11) 3427-3432; first published February 9, 2015. https://doi.org/10.1073/pnas.1422089112 - Open AccessPollinator recognition by a keystone tropical plantMatthew G. Betts, Adam S. Hadley, and W. John KressPNAS March 17, 2015 112 (11) 3433-3438; first published March 2, 2015. https://doi.org/10.1073/pnas.1419522112
Environmental Sciences
- Open AccessClimate change and pollution speed declines in zebrafish populationsA. Ross Brown, Stewart F. Owen, James Peters, Yong Zhang, Marta Soffker, Gregory C. Paull, David J. Hosken, M. Abdul Wahab, and Charles R. TylerPNAS March 17, 2015 112 (11) E1237-E1246; first published March 2, 2015. https://doi.org/10.1073/pnas.1416269112
Evolution
- Open AccessExtraordinary diversity of visual opsin genes in dragonflies
- From the Cover
Ryo Futahashi, Ryouka Kawahara-Miki, Michiyo Kinoshita, Kazutoshi Yoshitake, Shunsuke Yajima, Kentaro Arikawa, and Takema FukatsuPNAS March 17, 2015 112 (11) E1247-E1256; first published February 23, 2015. https://doi.org/10.1073/pnas.1424670112 - You have accessWhole-genome sequence of the Tibetan frog Nanorana parkeri and the comparative evolution of tetrapod genomesYan-Bo Sun, Zi-Jun Xiong, Xue-Yan Xiang, Shi-Ping Liu, Wei-Wei Zhou, Xiao-Long Tu, Li Zhong, Lu Wang, Dong-Dong Wu, Bao-Lin Zhang, Chun-Ling Zhu, Min-Min Yang, Hong-Man Chen, Fang Li, Long Zhou, Shao-Hong Feng, Chao Huang, Guo-Jie Zhang, David Irwin, David M. Hillis, Robert W. Murphy, Huan-Ming Yang, Jing Che, Jun Wang, and Ya-Ping ZhangPNAS March 17, 2015 112 (11) E1257-E1262; first published March 2, 2015. https://doi.org/10.1073/pnas.1501764112
- You have accessCore questions in domestication research
- Inaugural Article
Melinda A. ZederPNAS March 17, 2015 112 (11) 3191-3198; first published February 20, 2015. https://doi.org/10.1073/pnas.1501711112See companion article:
- Profile of Melinda A. Zeder- Apr 06, 2015
See companion article:
- Human behavioral ecology needs a rethink- Jun 01, 2015
- You have accessEvidence for recent, population-specific evolution of the human mutation rateKelley HarrisPNAS March 17, 2015 112 (11) 3439-3444; first published March 2, 2015. https://doi.org/10.1073/pnas.1418652112
Genetics
- Open AccessSequential de novo centromere formation and inactivation on a chromosomal fragment in maizeYalin Liu, Handong Su, Junling Pang, Zhi Gao, Xiu-Jie Wang, James A. Birchler, and Fangpu HanPNAS March 17, 2015 112 (11) E1263-E1271; first published March 2, 2015. https://doi.org/10.1073/pnas.1418248112
- You have accessRecurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinomaKalpana Kannan, Cristian Coarfa, Pei-Wen Chao, Liming Luo, Yan Wang, Amy E. Brinegar, Shannon M. Hawkins, Aleksandar Milosavljevic, Martin M. Matzuk, and Laising YenPNAS March 17, 2015 112 (11) E1272-E1277; first published March 2, 2015. https://doi.org/10.1073/pnas.1501735112
- You have accessImpacts of biological globalization in the Mediterranean: Unveiling the deep history of human-mediated gamebird dispersalGiovanni Forcina, Monica Guerrini, Hein van Grouw, Brij K. Gupta, Panicos Panayides, Pantelis Hadjigerou, Omar F. Al-Sheikhly, Muhammad N. Awan, Aleem A. Khan, Melinda A. Zeder, and Filippo BarbaneraPNAS March 17, 2015 112 (11) 3296-3301; first published March 2, 2015. https://doi.org/10.1073/pnas.1500677112
- Open AccessEpigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brainMeghan H. Puglia, Travis S. Lillard, James P. Morris, and Jessica J. ConnellyPNAS March 17, 2015 112 (11) 3308-3313; first published February 9, 2015. https://doi.org/10.1073/pnas.1422096112
- You have accessSystematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulatorsQinghong Yan, Sebastien M. Weyn-Vanhentenryck, Jie Wu, Steven A. Sloan, Ye Zhang, Kenian Chen, Jia Qian Wu, Ben A. Barres, and Chaolin ZhangPNAS March 17, 2015 112 (11) 3445-3450; first published March 3, 2015. https://doi.org/10.1073/pnas.1502849112
- You have accessHorizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogenBraham Dhillon, Nicolas Feau, Andrea L. Aerts, Stéphanie Beauseigle, Louis Bernier, Alex Copeland, Adam Foster, Navdeep Gill, Bernard Henrissat, Padmini Herath, Kurt M. LaButti, Anthony Levasseur, Erika A. Lindquist, Eline Majoor, Robin A. Ohm, Jasmyn L. Pangilinan, Amadeus Pribowo, John N. Saddler, Monique L. Sakalidis, Ronald P. de Vries, Igor V. Grigoriev, Stephen B. Goodwin, Philippe Tanguay, and Richard C. HamelinPNAS March 17, 2015 112 (11) 3451-3456; first published March 2, 2015. https://doi.org/10.1073/pnas.1424293112
Medical Sciences
- You have accessImplantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistanceJoão Conde, Nuria Oliva, and Natalie ArtziPNAS March 17, 2015 112 (11) E1278-E1287; first published March 2, 2015. https://doi.org/10.1073/pnas.1421229112
- You have accessAssessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancerAnthony C. Faber, Anna F. Farago, Carlotta Costa, Anahita Dastur, Maria Gomez-Caraballo, Rebecca Robbins, Bethany L. Wagner, William M. Rideout III, Charles T. Jakubik, Jungoh Ham, Elena J. Edelman, Hiromichi Ebi, Alan T. Yeo, Aaron N. Hata, Youngchul Song, Neha U. Patel, Ryan J. March, Ah Ting Tam, Randy J. Milano, Jessica L. Boisvert, Mark A. Hicks, Sarah Elmiligy, Scott E. Malstrom, Miguel N. Rivera, Hisashi Harada, Brad E. Windle, Sridhar Ramaswamy, Cyril H. Benes, Tyler Jacks, and Jeffrey A. EngelmanPNAS March 17, 2015 112 (11) E1288-E1296; first published March 3, 2015. https://doi.org/10.1073/pnas.1411848112
- Open AccessControlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activityNathaniel Washburn, Inessa Schwab, Daniel Ortiz, Naveen Bhatnagar, Jonathan C. Lansing, Amy Medeiros, Steven Tyler, Divya Mekala, Edward Cochran, Hetal Sarvaiya, Kevin Garofalo, Robin Meccariello, James W. Meador III, Laura Rutitzky, Birgit C. Schultes, Leona Ling, William Avery, Falk Nimmerjahn, Anthony M. Manning, Ganesh V. Kaundinya, and Carlos J. BosquesPNAS March 17, 2015 112 (11) E1297-E1306; first published March 2, 2015. https://doi.org/10.1073/pnas.1422481112
- You have accessOncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicingSaravana P. Selvanathan, Garrett T. Graham, Hayriye V. Erkizan, Uta Dirksen, Thanemozhi G. Natarajan, Aleksandra Dakic, Songtao Yu, Xuefeng Liu, Michelle T. Paulsen, Mats E. Ljungman, Cathy H. Wu, Elizabeth R. Lawlor, Aykut Üren, and Jeffrey A. ToretskyPNAS March 17, 2015 112 (11) E1307-E1316; first published March 3, 2015. https://doi.org/10.1073/pnas.1500536112
- Open AccessLengthening and shortening of plasma DNA in hepatocellular carcinoma patientsPeiyong Jiang, Carol W. M. Chan, K. C. Allen Chan, Suk Hang Cheng, John Wong, Vincent Wai-Sun Wong, Grace L. H. Wong, Stephen L. Chan, Tony S. K. Mok, Henry L. Y. Chan, Paul B. S. Lai, Rossa W. K. Chiu, and Y. M. Dennis LoPNAS March 17, 2015 112 (11) E1317-E1325; first published February 2, 2015. https://doi.org/10.1073/pnas.1500076112
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- Size selection in circulating tumor DNA- Mar 02, 2015
- You have accessQuorum-sensing Salmonella selectively trigger protein expression within tumorsCharles A. Swofford, Nele Van Dessel, and Neil S. ForbesPNAS March 17, 2015 112 (11) 3457-3462; first published March 3, 2015. https://doi.org/10.1073/pnas.1414558112
- You have accessInsulin resistance in brain alters dopamine turnover and causes behavioral disordersAndre Kleinridders, Weikang Cai, Laura Cappellucci, Armen Ghazarian, William R. Collins, Sara G. Vienberg, Emmanuel N. Pothos, and C. Ronald KahnPNAS March 17, 2015 112 (11) 3463-3468; first published March 2, 2015. https://doi.org/10.1073/pnas.1500877112
- You have accessThe RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancersJun Qian, Mohamed Hassanein, Megan D. Hoeksema, Bradford K. Harris, Yong Zou, Heidi Chen, Pengcheng Lu, Rosana Eisenberg, Jing Wang, Allan Espinosa, Xiangming Ji, Fredrick T. Harris, S. M. Jamshedur Rahman, and Pierre P. MassionPNAS March 17, 2015 112 (11) 3469-3474; first published March 2, 2015. https://doi.org/10.1073/pnas.1421975112
- You have accessAlpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimicsJan Balzarini, Kalyan Das, Jean A. Bernatchez, Sergio E. Martinez, Marianne Ngure, Sarah Keane, Alan Ford, Nuala Maguire, Niki Mullins, Jubi John, Youngju Kim, Wim Dehaen, Johan Vande Voorde, Sandra Liekens, Lieve Naesens, Matthias Götte, Anita R. Maguire, and Eddy ArnoldPNAS March 17, 2015 112 (11) 3475-3480; first published March 2, 2015. https://doi.org/10.1073/pnas.1420233112
- You have accessMacronutrient balance, reproductive function, and lifespan in aging miceSamantha M. Solon-Biet, Kirsty A. Walters, Ulla K. Simanainen, Aisling C. McMahon, Kari Ruohonen, John William O. Ballard, David Raubenheimer, David J. Handelsman, David G. Le Couteur, and Stephen J. SimpsonPNAS March 17, 2015 112 (11) 3481-3486; first published March 2, 2015. https://doi.org/10.1073/pnas.1422041112
- Open AccessLrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorptionLei Xiong, Ji-Ung Jung, Haitao Wu, Wen-Fang Xia, Jin-Xiu Pan, Chengyong Shen, Lin Mei, and Wen-Cheng XiongPNAS March 17, 2015 112 (11) 3487-3492; first published March 2, 2015. https://doi.org/10.1073/pnas.1419714112
- Open AccessPF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutationsHelen Y. Zou, Qiuhua Li, Lars D. Engstrom, Melissa West, Vicky Appleman, Katy A. Wong, Michele McTigue, Ya-Li Deng, Wei Liu, Alexei Brooun, Sergei Timofeevski, Scott R. P. McDonnell, Ping Jiang, Matthew D. Falk, Patrick B. Lappin, Timothy Affolter, Tim Nichols, Wenyue Hu, Justine Lam, Ted W. Johnson, Tod Smeal, Al Charest, and Valeria R. FantinPNAS March 17, 2015 112 (11) 3493-3498; first published March 2, 2015. https://doi.org/10.1073/pnas.1420785112
- You have accessp63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signalingElisa Maria Memmi, Anna Giulia Sanarico, Arianna Giacobbe, Angelo Peschiaroli, Valentina Frezza, Angelo Cicalese, Federica Pisati, Daniela Tosoni, Huiqing Zhou, Giovanni Tonon, Alexey Antonov, Gerry Melino, Pier Giuseppe Pelicci, and Francesca BernassolaPNAS March 17, 2015 112 (11) 3499-3504; first published March 4, 2015. https://doi.org/10.1073/pnas.1500762112
Microbiology
- You have accessDisentangling mechanisms that mediate the balance between stochastic and deterministic processes in microbial successionFrancisco Dini-Andreote, James C. Stegen, Jan Dirk van Elsas, and Joana Falcão SallesPNAS March 17, 2015 112 (11) E1326-E1332; first published March 2, 2015. https://doi.org/10.1073/pnas.1414261112
- You have accessNFκB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responsesMauro Di Pilato, Ernesto Mejías-Pérez, Manuela Zonca, Beatriz Perdiguero, Carmen Elena Gómez, Marianna Trakala, Jacobo Nieto, José Luis Nájera, Carlos Oscar S. Sorzano, Christophe Combadière, Giuseppe Pantaleo, Lourdes Planelles, and Mariano EstebanPNAS March 17, 2015 112 (11) E1333-E1342; first published March 4, 2015. https://doi.org/10.1073/pnas.1424341112
- Open AccessOrigin of the HIV-1 group O epidemic in western lowland gorillasMirela D’arc, Ahidjo Ayouba, Amandine Esteban, Gerald H. Learn, Vanina Boué, Florian Liegeois, Lucie Etienne, Nikki Tagg, Fabian H. Leendertz, Christophe Boesch, Nadège F. Madinda, Martha M. Robbins, Maryke Gray, Amandine Cournil, Marcel Ooms, Michael Letko, Viviana A. Simon, Paul M. Sharp, Beatrice H. Hahn, Eric Delaporte, Eitel Mpoudi Ngole, and Martine PeetersPNAS March 17, 2015 112 (11) E1343-E1352; first published March 2, 2015. https://doi.org/10.1073/pnas.1502022112
- You have accessRetroviral vectors elevate coexpressed protein levels in trans through cap-dependent translationYongqiang Gou, Hyewon Byun, Adam E. Zook, Gurvani B. Singh, Andrea K. Nash, Mary M. Lozano, and Jaquelin P. DudleyPNAS March 17, 2015 112 (11) 3505-3510; first published March 3, 2015. https://doi.org/10.1073/pnas.1420477112
- You have accessAcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificityJessica M. A. Blair, Vassiliy N. Bavro, Vito Ricci, Niraj Modi, Pierpaolo Cacciotto, Ulrich Kleinekathӧfer, Paolo Ruggerone, Attilio V. Vargiu, Alison J. Baylay, Helen E. Smith, Yvonne Brandon, David Galloway, and Laura J. V. PiddockPNAS March 17, 2015 112 (11) 3511-3516; first published March 3, 2015. https://doi.org/10.1073/pnas.1419939112
Neuroscience
- You have accessDisruption of hierarchical predictive coding during sleepMelanie Strauss, Jacobo D. Sitt, Jean-Remi King, Maxime Elbaz, Leila Azizi, Marco Buiatti, Lionel Naccache, Virginie van Wassenhove, and Stanislas DehaenePNAS March 17, 2015 112 (11) E1353-E1362; first published March 3, 2015. https://doi.org/10.1073/pnas.1501026112
- You have accessActivation of TRPM3 by a potent synthetic ligand reveals a role in peptide releaseKatharina Held, Tatjana Kichko, Katrien De Clercq, Hugo Klaassen, Rieta Van Bree, Jean-Christophe Vanherck, Arnaud Marchand, Peter W. Reeh, Patrick Chaltin, Thomas Voets, and Joris VriensPNAS March 17, 2015 112 (11) E1363-E1372; first published March 2, 2015. https://doi.org/10.1073/pnas.1419845112
- You have accessUp-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvationWuyang Wang, Qiong Gao, Meimei Yang, Xiaoli Zhang, Lu Yu, Maria Lawas, Xinran Li, Marthe Bryant-Genevier, Noel T. Southall, Juan Marugan, Marc Ferrer, and Haoxing XuPNAS March 17, 2015 112 (11) E1373-E1381; first published March 2, 2015. https://doi.org/10.1073/pnas.1419669112
- You have accessCoding principles of the canonical cortical microcircuit in the avian brain
- From the Cover
Ana Calabrese and Sarah M. N. WoolleyPNAS March 17, 2015 112 (11) 3517-3522; first published February 17, 2015. https://doi.org/10.1073/pnas.1408545112See companion article:
- Cortical computation in mammals and birds- Mar 09, 2015
- You have accessKCC2 activity is critical in limiting the onset and severity of status epilepticusLiliya Silayeva, Tarek Z. Deeb, Rochelle M. Hines, Matt R. Kelley, Michaelanne B. Munoz, Henry H. C. Lee, Nicholas J. Brandon, John Dunlop, Jaime Maguire, Paul A. Davies, and Stephen J. MossPNAS March 17, 2015 112 (11) 3523-3528; first published March 2, 2015. https://doi.org/10.1073/pnas.1415126112
- You have accessStochastic transitions into silence cause noise correlations in cortical circuitsGabriela Mochol, Ainhoa Hermoso-Mendizabal, Shuzo Sakata, Kenneth D. Harris, and Jaime de la RochaPNAS March 17, 2015 112 (11) 3529-3534; first published March 4, 2015. https://doi.org/10.1073/pnas.1410509112
- Open AccessCortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillationsTae Kim, Stephen Thankachan, James T. McKenna, James M. McNally, Chun Yang, Jee Hyun Choi, Lichao Chen, Bernat Kocsis, Karl Deisseroth, Robert E. Strecker, Radhika Basheer, Ritchie E. Brown, and Robert W. McCarleyPNAS March 17, 2015 112 (11) 3535-3540; first published March 2, 2015. https://doi.org/10.1073/pnas.1413625112
- Open AccessModeling memory consolidation during posttraining periods in cerebellovestibular learningTadashi Yamazaki, Soichi Nagao, William Lennon, and Shigeru TanakaPNAS March 17, 2015 112 (11) 3541-3546; first published March 3, 2015. https://doi.org/10.1073/pnas.1413798112
Pharmacology
- You have accessGlutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cellsYifan Hong, Yau-Tsz Lai, Godfrey Chi-Fung Chan, and Hongzhe SunPNAS March 17, 2015 112 (11) 3211-3216; first published March 3, 2015. https://doi.org/10.1073/pnas.1421002112
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- Systems pharmacology for metallodrugs- Mar 30, 2015
Physiology
- You have accessActivation of protein synthesis in mouse uterine epithelial cells by estradiol-17β is mediated by a PKC–ERK1/2–mTOR signaling pathwayYuxiang Wang, Liyin Zhu, Satu Kuokkanen, and Jeffrey W. PollardPNAS March 17, 2015 112 (11) E1382-E1391; first published March 2, 2015. https://doi.org/10.1073/pnas.1418973112
- You have accessFour basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channelsChristian J. Peters, Haibo Yu, Jason Tien, Yuh Nung Jan, Min Li, and Lily Yeh JanPNAS March 17, 2015 112 (11) 3547-3552; first published March 2, 2015. https://doi.org/10.1073/pnas.1502291112
Plant Biology
- You have accessThioredoxin, a master regulator of the tricarboxylic acid cycle in plant mitochondriaDanilo M. Daloso, Karolin Müller, Toshihiro Obata, Alexandra Florian, Takayuki Tohge, Alexandra Bottcher, Christophe Riondet, Laetitia Bariat, Fernando Carrari, Adriano Nunes-Nesi, Bob B. Buchanan, Jean-Philippe Reichheld, Wagner L. Araújo, and Alisdair R. FerniePNAS March 17, 2015 112 (11) E1392-E1400; first published February 2, 2015. https://doi.org/10.1073/pnas.1424840112
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- Mitochondrial metabolism regulated by thioredoxin- Mar 09, 2015
- You have accessRegulatory link between DNA methylation and active demethylation in ArabidopsisMingguang Lei, Huiming Zhang, Russell Julian, Kai Tang, Shaojun Xie, and Jian-Kang ZhuPNAS March 17, 2015 112 (11) 3553-3557; first published March 2, 2015. https://doi.org/10.1073/pnas.1502279112
- You have accessArabidopsis OR proteins are the major posttranscriptional regulators of phytoene synthase in controlling carotenoid biosynthesisXiangjun Zhou, Ralf Welsch, Yong Yang, Daniel Álvarez, Matthias Riediger, Hui Yuan, Tara Fish, Jiping Liu, Theodore W. Thannhauser, and Li LiPNAS March 17, 2015 112 (11) 3558-3563; first published February 9, 2015. https://doi.org/10.1073/pnas.1420831112
- You have accessImproving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperoneSpencer M. Whitney, Rosemary Birch, Celine Kelso, Jennifer L. Beck, and Maxim V. KapralovPNAS March 17, 2015 112 (11) 3564-3569; first published March 2, 2015. https://doi.org/10.1073/pnas.1420536112
- You have accessBoosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing systemKabin Xie, Bastian Minkenberg, and Yinong YangPNAS March 17, 2015 112 (11) 3570-3575; first published March 2, 2015. https://doi.org/10.1073/pnas.1420294112
Systems Biology
- You have accessRare variants in neuronal excitability genes influence risk for bipolar disorderSeth A. Ament, Szabolcs Szelinger, Gustavo Glusman, Justin Ashworth, Liping Hou, Nirmala Akula, Tatyana Shekhtman, Judith A. Badner, Mary E. Brunkow, Denise E. Mauldin, Anna-Barbara Stittrich, Katherine Rouleau, Sevilla D. Detera-Wadleigh, John I. Nurnberger Jr., Howard J. Edenberg, Elliot S. Gershon, Nicholas Schork, The Bipolar Genome Study, Nathan D. Price, Richard Gelinas, Leroy Hood, David Craig, Francis J. McMahon, John R. Kelsoe, and Jared C. RoachPNAS March 17, 2015 112 (11) 3576-3581; first published February 17, 2015. https://doi.org/10.1073/pnas.1424958112
Correction (Online Only)
- You have accessCorrection for Bartesaghi et al., Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cellsPNAS March 17, 2015 112 (11) E1401; first published February 20, 2015. https://doi.org/10.1073/pnas.1503132112
Commentaries
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