Proceedings of the National Academy of Sciences: 112 (11)

New Research In

March 17, 2015; vol. 112 no. 11

This Week in PNAS

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In This Issue
PNAS March 17, 2015 112 (11) 3171-3172; https://doi.org/10.1073/iti1115112

PNAS 100th Anniversary Article

Commentary
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  Hubble’s Law and the expanding universe
  Neta A. Bahcall
  
  PNAS March 17, 2015 112 (11) 3173-3175; https://doi.org/10.1073/pnas.1424299112
  
  See companion article:
  Hubble's quarter century in orbit
  - Mar 17, 2015
  
  A relation between distance and radial velocity among extra-galactic nebulae
  - Mar 15, 1929

Letters (Online Only)

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Big changes before big birthdays? Panel data provide no evidence of end-of-decade crises
Simon Kühne, Thorsten Schneider, and David Richter

PNAS March 17, 2015 112 (11) E1170; first published February 18, 2015. https://doi.org/10.1073/pnas.1424903112
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Reply to Kühne et al.: Still good evidence that people search for meaning when they approach a new decade in chronological age
Adam L. Alter and Hal E. Hershfield

PNAS March 17, 2015 112 (11) E1171; first published February 18, 2015. https://doi.org/10.1073/pnas.1500787112
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New decades in age and the search for meaning
- Nov 17, 2014
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Titin ruler hypothesis not refuted
Larissa Tskhovrebova, Pauline Bennett, Mathias Gautel, and John Trinick

PNAS March 17, 2015 112 (11) E1172; first published February 18, 2015. https://doi.org/10.1073/pnas.1422326112
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Reply to Tskhovrebova et al.: Titin’s IA junction does not control thick filament length
Henk L. Granzier

PNAS March 17, 2015 112 (11) E1173; first published February 18, 2015. https://doi.org/10.1073/pnas.1500871112
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Titin's role in muscle structure and function
- Sep 22, 2014

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: Hubble’s quarter century in orbit has opened a universe of possibilities
Front Matter
David J. Harris

PNAS March 17, 2015 112 (11) 3176-3177; https://doi.org/10.1073/pnas.1500872112
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Hubble's Law and the expanding universe
- Mar 17, 2015

Commentaries

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Circulating tumor-derived DNA is shorter than somatic DNA in plasma
Florent Mouliere and Nitzan Rosenfeld

PNAS March 17, 2015 112 (11) 3178-3179; first published March 2, 2015. https://doi.org/10.1073/pnas.1501321112
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Lengthening and shortening of plasma DNA in cancer
- Feb 02, 2015
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Mitochondrial metabolism is regulated by thioredoxin
Ian Max Møller

PNAS March 17, 2015 112 (11) 3180-3181; first published March 9, 2015. https://doi.org/10.1073/pnas.1502425112
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Thioredoxin-mediated TCA cycle regulation
- Feb 02, 2015
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Stimulating minds to wander
James M. Broadway, Claire M. Zedelius, Benjamin W. Mooneyham, Michael D. Mrazek, and Jonathan W. Schooler

PNAS March 17, 2015 112 (11) 3182-3183; first published March 9, 2015. https://doi.org/10.1073/pnas.1503093112
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Increasing propensity to mind-wander with tDCS
- Feb 17, 2015
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Cortical computation in mammals and birds
Kenneth D. Harris

PNAS March 17, 2015 112 (11) 3184-3185; first published March 9, 2015. https://doi.org/10.1073/pnas.1502209112
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Neocortical microcircuit in the avian brain
- Feb 17, 2015

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS March 17, 2015 112 (11) 3186-3190; https://doi.org/10.1073/pnas.ss11211

Physical Sciences

Applied Physical Sciences
- Open Access
  Polytypism, polymorphism, and superconductivity in TaSe₂_−xTe_x
  Huixia Luo, Weiwei Xie, Jing Tao, Hiroyuki Inoue, András Gyenis, Jason W. Krizan, Ali Yazdani, Yimei Zhu, and Robert Joseph Cava
  
  PNAS March 17, 2015 112 (11) E1174-E1180; first published March 3, 2015. https://doi.org/10.1073/pnas.1502460112
- Open Access
  Nucleation of metastable aragonite CaCO₃ in seawater
  Wenhao Sun, Saivenkataraman Jayaraman, Wei Chen, Kristin A. Persson, and Gerbrand Ceder
  
  PNAS March 17, 2015 112 (11) 3199-3204; first published March 4, 2015. https://doi.org/10.1073/pnas.1423898112
Chemistry
- Open Access
  De novo production of the plant-derived alkaloid strictosidine in yeast
  Stephanie Brown, Marc Clastre, Vincent Courdavault, and Sarah E. O’Connor
  
  PNAS March 17, 2015 112 (11) 3205-3210; first published February 9, 2015. https://doi.org/10.1073/pnas.1423555112
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  Glutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cells
  Yifan Hong, Yau-Tsz Lai, Godfrey Chi-Fung Chan, and Hongzhe Sun
  
  PNAS March 17, 2015 112 (11) 3211-3216; first published March 3, 2015. https://doi.org/10.1073/pnas.1421002112
  
  See companion article:
  Systems pharmacology for metallodrugs
  - Mar 30, 2015
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  Spray-combustion synthesis: Efficient solution route to high-performance oxide transistors
  From the Cover
  
  Xinge Yu, Jeremy Smith, Nanjia Zhou, Li Zeng, Peijun Guo, Yu Xia, Ana Alvarez, Stefano Aghion, Hui Lin, Junsheng Yu, Robert P. H. Chang, Michael J. Bedzyk, Rafael Ferragut, Tobin J. Marks, and Antonio Facchetti
  
  PNAS March 17, 2015 112 (11) 3217-3222; first published March 2, 2015. https://doi.org/10.1073/pnas.1501548112
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  Structure of superhard tungsten tetraboride: A missing link between MB₂ and MB₁₂ higher borides
  Andrew T. Lech, Christopher L. Turner, Reza Mohammadi, Sarah H. Tolbert, and Richard B. Kaner
  
  PNAS March 17, 2015 112 (11) 3223-3228; first published March 2, 2015. https://doi.org/10.1073/pnas.1415018112
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  Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity
  Chunte Sam Peng, Bogdan I. Fedeles, Vipender Singh, Deyu Li, Tiffany Amariuta, John M. Essigmann, and Andrei Tokmakoff
  
  PNAS March 17, 2015 112 (11) 3229-3234; first published March 2, 2015. https://doi.org/10.1073/pnas.1415974112
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  Locating landmarks on high-dimensional free energy surfaces
  Ming Chen, Tang-Qing Yu, and Mark E. Tuckerman
  
  PNAS March 17, 2015 112 (11) 3235-3240; first published March 3, 2015. https://doi.org/10.1073/pnas.1418241112
Earth, Atmospheric, and Planetary Sciences
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  Climate change in the Fertile Crescent and implications of the recent Syrian drought
  Colin P. Kelley, Shahrzad Mohtadi, Mark A. Cane, Richard Seager, and Yochanan Kushnir
  
  PNAS March 17, 2015 112 (11) 3241-3246; first published March 2, 2015. https://doi.org/10.1073/pnas.1421533112
- Open Access
  Vapor hydrogen and oxygen isotopes reflect water of combustion in the urban atmosphere
  Galen Gorski, Courtenay Strong, Stephen P. Good, Ryan Bares, James R. Ehleringer, and Gabriel J. Bowen
  
  PNAS March 17, 2015 112 (11) 3247-3252; first published March 2, 2015. https://doi.org/10.1073/pnas.1424728112
- Open Access
  Dynamical evidence for causality between galactic cosmic rays and interannual variation in global temperature
  Anastasios A. Tsonis, Ethan R. Deyle, Robert M. May, George Sugihara, Kyle Swanson, Joshua D. Verbeten, and Geli Wang
  
  PNAS March 17, 2015 112 (11) 3253-3256; first published March 2, 2015. https://doi.org/10.1073/pnas.1420291112
  
  See companion article:
  Causal effects of cosmic rays on temperature
  - Aug 17, 2015
- Open Access
  Effects of large-scale deforestation on precipitation in the monsoon regions: Remote versus local effects
  N. Devaraju, Govindasamy Bala, and Angshuman Modak
  
  PNAS March 17, 2015 112 (11) 3257-3262; first published March 2, 2015. https://doi.org/10.1073/pnas.1423439112
- Open Access
  Ocean-driven thinning enhances iceberg calving and retreat of Antarctic ice shelves
  Yan Liu, John C. Moore, Xiao Cheng, Rupert M. Gladstone, Jeremy N. Bassis, Hongxing Liu, Jiahong Wen, and Fengming Hui
  
  PNAS March 17, 2015 112 (11) 3263-3268; first published March 2, 2015. https://doi.org/10.1073/pnas.1415137112
Engineering
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  Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance
  João Conde, Nuria Oliva, and Natalie Artzi
  
  PNAS March 17, 2015 112 (11) E1278-E1287; first published March 2, 2015. https://doi.org/10.1073/pnas.1421229112
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  Quorum-sensing Salmonella selectively trigger protein expression within tumors
  Charles A. Swofford, Nele Van Dessel, and Neil S. Forbes
  
  PNAS March 17, 2015 112 (11) 3457-3462; first published March 3, 2015. https://doi.org/10.1073/pnas.1414558112
Physics
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  n-type thermoelectric material Mg₂Sn_0.75Ge_0.25 for high power generation
  Weishu Liu, Hee Seok Kim, Shuo Chen, Qing Jie, Bing Lv, Mengliang Yao, Zhensong Ren, Cyril P. Opeil, Stephen Wilson, Ching-Wu Chu, and Zhifeng Ren
  
  PNAS March 17, 2015 112 (11) 3269-3274; first published March 2, 2015. https://doi.org/10.1073/pnas.1424388112
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  The second laws of quantum thermodynamics
  Fernando Brandão, Michał Horodecki, Nelly Ng, Jonathan Oppenheim, and Stephanie Wehner
  
  PNAS March 17, 2015 112 (11) 3275-3279; first published February 9, 2015. https://doi.org/10.1073/pnas.1411728112
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  Kelvin–Helmholtz instability in an ultrathin air film causes drop splashing on smooth surfaces
  Yuan Liu, Peng Tan, and Lei Xu
  
  PNAS March 17, 2015 112 (11) 3280-3284; first published February 23, 2015. https://doi.org/10.1073/pnas.1417718112
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  Avoided valence transition in a plutonium superconductor
  B. J. Ramshaw, Arkady Shekhter, Ross D. McDonald, Jon B. Betts, J. N. Mitchell, P. H. Tobash, C. H. Mielke, E. D. Bauer, and Albert Migliori
  
  PNAS March 17, 2015 112 (11) 3285-3289; first published March 3, 2015. https://doi.org/10.1073/pnas.1421174112
- Open Access
  Dynamical phase transition in the open Dicke model
  Jens Klinder, Hans Keßler, Matthias Wolke, Ludwig Mathey, and Andreas Hemmerich
  
  PNAS March 17, 2015 112 (11) 3290-3295; first published March 2, 2015. https://doi.org/10.1073/pnas.1417132112

Biological Sciences

Applied Biological Sciences
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  Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution
  Alice Tzeng, Byron H. Kwan, Cary F. Opel, Tejas Navaratna, and K. Dane Wittrup
  
  PNAS March 17, 2015 112 (11) 3320-3325; first published March 2, 2015. https://doi.org/10.1073/pnas.1416159112
Biochemistry
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  Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution
  Matthias Hillenbrand, Christian Schori, Jendrik Schöppe, and Andreas Plückthun
  
  PNAS March 17, 2015 112 (11) E1181-E1190; first published March 2, 2015. https://doi.org/10.1073/pnas.1417573112
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  Dramatically reduced spliceosome in Cyanidioschyzon merolae
  Martha R. Stark, Elizabeth A. Dunn, William S. C. Dunn, Cameron J. Grisdale, Anthony R. Daniele, Matthew R. G. Halstead, Naomi M. Fast, and Stephen D. Rader
  
  PNAS March 17, 2015 112 (11) E1191-E1200; first published March 2, 2015. https://doi.org/10.1073/pnas.1416879112
- Open Access
  Myosin VI deafness mutation prevents the initiation of processive runs on actin
  Olena Pylypenko, Lin Song, Ai Shima, Zhaohui Yang, Anne M. Houdusse, and H. Lee Sweeney
  
  PNAS March 17, 2015 112 (11) E1201-E1209; first published March 6, 2015. https://doi.org/10.1073/pnas.1420989112
- Open Access
  De novo production of the plant-derived alkaloid strictosidine in yeast
  Stephanie Brown, Marc Clastre, Vincent Courdavault, and Sarah E. O’Connor
  
  PNAS March 17, 2015 112 (11) 3205-3210; first published February 9, 2015. https://doi.org/10.1073/pnas.1423555112
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  Steric clashes with bound OMP peptides activate the DegS stress-response protease
  Anna K. de Regt, Tania A. Baker, and Robert T. Sauer
  
  PNAS March 17, 2015 112 (11) 3326-3331; first published March 2, 2015. https://doi.org/10.1073/pnas.1502372112
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  Functional analysis of (4S)-limonene synthase mutants reveals determinants of catalytic outcome in a model monoterpene synthase
  Narayanan Srividya, Edward M. Davis, Rodney B. Croteau, and B. Markus Lange
  
  PNAS March 17, 2015 112 (11) 3332-3337; first published March 2, 2015. https://doi.org/10.1073/pnas.1501203112
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  Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo
  Tsz-Leung To, Beverly J. Piggott, Kalpana Makhijani, Dan Yu, Yuh Nung Jan, and Xiaokun Shu
  
  PNAS March 17, 2015 112 (11) 3338-3343; first published March 2, 2015. https://doi.org/10.1073/pnas.1502857112
- Open Access
  Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
  Shangyu Dang, Shenjie Wu, Jiawei Wang, Hongbo Li, Min Huang, Wei He, Yue-Ming Li, Catherine C. L. Wong, and Yigong Shi
  
  PNAS March 17, 2015 112 (11) 3344-3349; first published March 2, 2015. https://doi.org/10.1073/pnas.1502150112
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  Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation
  Sho W. Suzuki, Hayashi Yamamoto, Yu Oikawa, Chika Kondo-Kakuta, Yayoi Kimura, Hisashi Hirano, and Yoshinori Ohsumi
  
  PNAS March 17, 2015 112 (11) 3350-3355; first published March 3, 2015. https://doi.org/10.1073/pnas.1421092112
- Open Access
  Plasmodium falciparum chloroquine resistance transporter is a H⁺-coupled polyspecific nutrient and drug exporter
  Narinobu Juge, Sawako Moriyama, Takaaki Miyaji, Mamiyo Kawakami, Haruka Iwai, Tomoya Fukui, Nathan Nelson, Hiroshi Omote, and Yoshinori Moriyama
  
  PNAS March 17, 2015 112 (11) 3356-3361; first published March 2, 2015. https://doi.org/10.1073/pnas.1417102112
Biophysics and Computational Biology
- Open Access
  Salient features of otoacoustic emissions are common across tetrapod groups and suggest shared properties of generation mechanisms
  Christopher Bergevin, Geoffrey A. Manley, and Christine Köppl
  
  PNAS March 17, 2015 112 (11) 3362-3367; first published March 3, 2015. https://doi.org/10.1073/pnas.1418569112
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  Electron crystallography of ultrathin 3D protein crystals: Atomic model with charges
  Koji Yonekura, Kazuyuki Kato, Mitsuo Ogasawara, Masahiro Tomita, and Chikashi Toyoshima
  
  PNAS March 17, 2015 112 (11) 3368-3373; first published February 17, 2015. https://doi.org/10.1073/pnas.1500724112
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  Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy
  Lalit Deshmukh, Rodolfo Ghirlando, and G. Marius Clore
  
  PNAS March 17, 2015 112 (11) 3374-3379; first published February 23, 2015. https://doi.org/10.1073/pnas.1501985112
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  Nanomechanics and intermolecular forces of amyloid revealed by four-dimensional electron microscopy
  Anthony W. P. Fitzpatrick, Giovanni M. Vanacore, and Ahmed H. Zewail
  
  PNAS March 17, 2015 112 (11) 3380-3385; first published March 2, 2015. https://doi.org/10.1073/pnas.1502214112
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  L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel
  Jinfeng Teng, Stephen H. Loukin, Andriy Anishkin, and Ching Kung
  
  PNAS March 17, 2015 112 (11) 3386-3391; first published March 3, 2015. https://doi.org/10.1073/pnas.1502366112
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  Pigeons trade efficiency for stability in response to level of challenge during confined flight
  C. David Williams and Andrew A. Biewener
  
  PNAS March 17, 2015 112 (11) 3392-3396; first published March 2, 2015. https://doi.org/10.1073/pnas.1407298112
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  Mutation of a single residue in the ba₃ oxidase specifically impairs protonation of the pump site
  Christoph von Ballmoos, Nathalie Gonska, Peter Lachmann, Robert B. Gennis, Pia Ädelroth, and Peter Brzezinski
  
  PNAS March 17, 2015 112 (11) 3397-3402; first published March 2, 2015. https://doi.org/10.1073/pnas.1422434112
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  Cation-induced kinetic heterogeneity of the intron–exon recognition in single group II introns
  Danny Kowerko, Sebastian L. B. König, Miriam Skilandat, Daniela Kruschel, Mélodie C. A. S. Hadzic, Lucia Cardo, and Roland K. O. Sigel
  
  PNAS March 17, 2015 112 (11) 3403-3408; first published March 3, 2015. https://doi.org/10.1073/pnas.1322759112
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  Structure and dynamics of the MKK7–JNK signaling complex
  Jaka Kragelj, Andrés Palencia, Max H. Nanao, Damien Maurin, Guillaume Bouvignies, Martin Blackledge, and Malene Ringkjøbing Jensen
  
  PNAS March 17, 2015 112 (11) 3409-3414; first published March 3, 2015. https://doi.org/10.1073/pnas.1419528112
Cell Biology
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  BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1
  Chunmin Ge, Lixiao Che, Jinyu Ren, Raj K. Pandita, Jing Lu, Kaiyi Li, Tej K. Pandita, and Chunying Du
  
  PNAS March 17, 2015 112 (11) E1210-E1219; first published March 2, 2015. https://doi.org/10.1073/pnas.1418335112
- Open Access
  Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4
  Alla Polotskaia, Gu Xiao, Katherine Reynoso, Che Martin, Wei-Gang Qiu, Ronald C. Hendrickson, and Jill Bargonetti
  
  PNAS March 17, 2015 112 (11) E1220-E1229; first published March 2, 2015. https://doi.org/10.1073/pnas.1416318112
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  Endocannabinoids are conserved inhibitors of the Hedgehog pathway
  Helena Khaliullina, Mesut Bilgin, Julio L. Sampaio, Andrej Shevchenko, and Suzanne Eaton
  
  PNAS March 17, 2015 112 (11) 3415-3420; first published March 2, 2015. https://doi.org/10.1073/pnas.1416463112
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  Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression
  Kristen M. Turner, Youting Sun, Ping Ji, Kirsi J. Granberg, Brady Bernard, Limei Hu, David E. Cogdell, Xinhui Zhou, Olli Yli-Harja, Matti Nykter, Ilya Shmulevich, W. K. Alfred Yung, Gregory N. Fuller, and Wei Zhang
  
  PNAS March 17, 2015 112 (11) 3421-3426; first published March 3, 2015. https://doi.org/10.1073/pnas.1414573112
Ecology
- Open Access
  Hadal biosphere: Insight into the microbial ecosystem in the deepest ocean on Earth
  Takuro Nunoura, Yoshihiro Takaki, Miho Hirai, Shigeru Shimamura, Akiko Makabe, Osamu Koide, Tohru Kikuchi, Junichi Miyazaki, Keisuke Koba, Naohiro Yoshida, Michinari Sunamura, and Ken Takai
  
  PNAS March 17, 2015 112 (11) E1230-E1236; first published February 23, 2015. https://doi.org/10.1073/pnas.1421816112
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  Rapid behavioral maturation accelerates failure of stressed honey bee colonies
  From the Cover
  
  Clint J. Perry, Eirik Søvik, Mary R. Myerscough, and Andrew B. Barron
  
  PNAS March 17, 2015 112 (11) 3427-3432; first published February 9, 2015. https://doi.org/10.1073/pnas.1422089112
- Open Access
  Pollinator recognition by a keystone tropical plant
  Matthew G. Betts, Adam S. Hadley, and W. John Kress
  
  PNAS March 17, 2015 112 (11) 3433-3438; first published March 2, 2015. https://doi.org/10.1073/pnas.1419522112
Environmental Sciences
- Open Access
  Climate change and pollution speed declines in zebrafish populations
  A. Ross Brown, Stewart F. Owen, James Peters, Yong Zhang, Marta Soffker, Gregory C. Paull, David J. Hosken, M. Abdul Wahab, and Charles R. Tyler
  
  PNAS March 17, 2015 112 (11) E1237-E1246; first published March 2, 2015. https://doi.org/10.1073/pnas.1416269112
Evolution
- Open Access
  Extraordinary diversity of visual opsin genes in dragonflies
  From the Cover
  
  Ryo Futahashi, Ryouka Kawahara-Miki, Michiyo Kinoshita, Kazutoshi Yoshitake, Shunsuke Yajima, Kentaro Arikawa, and Takema Fukatsu
  
  PNAS March 17, 2015 112 (11) E1247-E1256; first published February 23, 2015. https://doi.org/10.1073/pnas.1424670112
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  Whole-genome sequence of the Tibetan frog Nanorana parkeri and the comparative evolution of tetrapod genomes
  Yan-Bo Sun, Zi-Jun Xiong, Xue-Yan Xiang, Shi-Ping Liu, Wei-Wei Zhou, Xiao-Long Tu, Li Zhong, Lu Wang, Dong-Dong Wu, Bao-Lin Zhang, Chun-Ling Zhu, Min-Min Yang, Hong-Man Chen, Fang Li, Long Zhou, Shao-Hong Feng, Chao Huang, Guo-Jie Zhang, David Irwin, David M. Hillis, Robert W. Murphy, Huan-Ming Yang, Jing Che, Jun Wang, and Ya-Ping Zhang
  
  PNAS March 17, 2015 112 (11) E1257-E1262; first published March 2, 2015. https://doi.org/10.1073/pnas.1501764112
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  Core questions in domestication research
  Inaugural Article
  
  Melinda A. Zeder
  
  PNAS March 17, 2015 112 (11) 3191-3198; first published February 20, 2015. https://doi.org/10.1073/pnas.1501711112
  
  See companion article:
  Profile of Melinda A. Zeder
  - Apr 06, 2015
  
  See companion article:
  Human behavioral ecology needs a rethink
  - Jun 01, 2015
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  Evidence for recent, population-specific evolution of the human mutation rate
  Kelley Harris
  
  PNAS March 17, 2015 112 (11) 3439-3444; first published March 2, 2015. https://doi.org/10.1073/pnas.1418652112
Genetics
- Open Access
  Sequential de novo centromere formation and inactivation on a chromosomal fragment in maize
  Yalin Liu, Handong Su, Junling Pang, Zhi Gao, Xiu-Jie Wang, James A. Birchler, and Fangpu Han
  
  PNAS March 17, 2015 112 (11) E1263-E1271; first published March 2, 2015. https://doi.org/10.1073/pnas.1418248112
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  Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma
  Kalpana Kannan, Cristian Coarfa, Pei-Wen Chao, Liming Luo, Yan Wang, Amy E. Brinegar, Shannon M. Hawkins, Aleksandar Milosavljevic, Martin M. Matzuk, and Laising Yen
  
  PNAS March 17, 2015 112 (11) E1272-E1277; first published March 2, 2015. https://doi.org/10.1073/pnas.1501735112
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  Impacts of biological globalization in the Mediterranean: Unveiling the deep history of human-mediated gamebird dispersal
  Giovanni Forcina, Monica Guerrini, Hein van Grouw, Brij K. Gupta, Panicos Panayides, Pantelis Hadjigerou, Omar F. Al-Sheikhly, Muhammad N. Awan, Aleem A. Khan, Melinda A. Zeder, and Filippo Barbanera
  
  PNAS March 17, 2015 112 (11) 3296-3301; first published March 2, 2015. https://doi.org/10.1073/pnas.1500677112
- Open Access
  Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain
  Meghan H. Puglia, Travis S. Lillard, James P. Morris, and Jessica J. Connelly
  
  PNAS March 17, 2015 112 (11) 3308-3313; first published February 9, 2015. https://doi.org/10.1073/pnas.1422096112
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  Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators
  Qinghong Yan, Sebastien M. Weyn-Vanhentenryck, Jie Wu, Steven A. Sloan, Ye Zhang, Kenian Chen, Jia Qian Wu, Ben A. Barres, and Chaolin Zhang
  
  PNAS March 17, 2015 112 (11) 3445-3450; first published March 3, 2015. https://doi.org/10.1073/pnas.1502849112
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  Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen
  Braham Dhillon, Nicolas Feau, Andrea L. Aerts, Stéphanie Beauseigle, Louis Bernier, Alex Copeland, Adam Foster, Navdeep Gill, Bernard Henrissat, Padmini Herath, Kurt M. LaButti, Anthony Levasseur, Erika A. Lindquist, Eline Majoor, Robin A. Ohm, Jasmyn L. Pangilinan, Amadeus Pribowo, John N. Saddler, Monique L. Sakalidis, Ronald P. de Vries, Igor V. Grigoriev, Stephen B. Goodwin, Philippe Tanguay, and Richard C. Hamelin
  
  PNAS March 17, 2015 112 (11) 3451-3456; first published March 2, 2015. https://doi.org/10.1073/pnas.1424293112
Medical Sciences
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  Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance
  João Conde, Nuria Oliva, and Natalie Artzi
  
  PNAS March 17, 2015 112 (11) E1278-E1287; first published March 2, 2015. https://doi.org/10.1073/pnas.1421229112
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  Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer
  Anthony C. Faber, Anna F. Farago, Carlotta Costa, Anahita Dastur, Maria Gomez-Caraballo, Rebecca Robbins, Bethany L. Wagner, William M. Rideout III, Charles T. Jakubik, Jungoh Ham, Elena J. Edelman, Hiromichi Ebi, Alan T. Yeo, Aaron N. Hata, Youngchul Song, Neha U. Patel, Ryan J. March, Ah Ting Tam, Randy J. Milano, Jessica L. Boisvert, Mark A. Hicks, Sarah Elmiligy, Scott E. Malstrom, Miguel N. Rivera, Hisashi Harada, Brad E. Windle, Sridhar Ramaswamy, Cyril H. Benes, Tyler Jacks, and Jeffrey A. Engelman
  
  PNAS March 17, 2015 112 (11) E1288-E1296; first published March 3, 2015. https://doi.org/10.1073/pnas.1411848112
- Open Access
  Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity
  Nathaniel Washburn, Inessa Schwab, Daniel Ortiz, Naveen Bhatnagar, Jonathan C. Lansing, Amy Medeiros, Steven Tyler, Divya Mekala, Edward Cochran, Hetal Sarvaiya, Kevin Garofalo, Robin Meccariello, James W. Meador III, Laura Rutitzky, Birgit C. Schultes, Leona Ling, William Avery, Falk Nimmerjahn, Anthony M. Manning, Ganesh V. Kaundinya, and Carlos J. Bosques
  
  PNAS March 17, 2015 112 (11) E1297-E1306; first published March 2, 2015. https://doi.org/10.1073/pnas.1422481112
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  Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing
  Saravana P. Selvanathan, Garrett T. Graham, Hayriye V. Erkizan, Uta Dirksen, Thanemozhi G. Natarajan, Aleksandra Dakic, Songtao Yu, Xuefeng Liu, Michelle T. Paulsen, Mats E. Ljungman, Cathy H. Wu, Elizabeth R. Lawlor, Aykut Üren, and Jeffrey A. Toretsky
  
  PNAS March 17, 2015 112 (11) E1307-E1316; first published March 3, 2015. https://doi.org/10.1073/pnas.1500536112
- Open Access
  Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
  Peiyong Jiang, Carol W. M. Chan, K. C. Allen Chan, Suk Hang Cheng, John Wong, Vincent Wai-Sun Wong, Grace L. H. Wong, Stephen L. Chan, Tony S. K. Mok, Henry L. Y. Chan, Paul B. S. Lai, Rossa W. K. Chiu, and Y. M. Dennis Lo
  
  PNAS March 17, 2015 112 (11) E1317-E1325; first published February 2, 2015. https://doi.org/10.1073/pnas.1500076112
  
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  Size selection in circulating tumor DNA
  - Mar 02, 2015
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  Quorum-sensing Salmonella selectively trigger protein expression within tumors
  Charles A. Swofford, Nele Van Dessel, and Neil S. Forbes
  
  PNAS March 17, 2015 112 (11) 3457-3462; first published March 3, 2015. https://doi.org/10.1073/pnas.1414558112
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  Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
  Andre Kleinridders, Weikang Cai, Laura Cappellucci, Armen Ghazarian, William R. Collins, Sara G. Vienberg, Emmanuel N. Pothos, and C. Ronald Kahn
  
  PNAS March 17, 2015 112 (11) 3463-3468; first published March 2, 2015. https://doi.org/10.1073/pnas.1500877112
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  The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers
  Jun Qian, Mohamed Hassanein, Megan D. Hoeksema, Bradford K. Harris, Yong Zou, Heidi Chen, Pengcheng Lu, Rosana Eisenberg, Jing Wang, Allan Espinosa, Xiangming Ji, Fredrick T. Harris, S. M. Jamshedur Rahman, and Pierre P. Massion
  
  PNAS March 17, 2015 112 (11) 3469-3474; first published March 2, 2015. https://doi.org/10.1073/pnas.1421975112
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  Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics
  Jan Balzarini, Kalyan Das, Jean A. Bernatchez, Sergio E. Martinez, Marianne Ngure, Sarah Keane, Alan Ford, Nuala Maguire, Niki Mullins, Jubi John, Youngju Kim, Wim Dehaen, Johan Vande Voorde, Sandra Liekens, Lieve Naesens, Matthias Götte, Anita R. Maguire, and Eddy Arnold
  
  PNAS March 17, 2015 112 (11) 3475-3480; first published March 2, 2015. https://doi.org/10.1073/pnas.1420233112
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  Macronutrient balance, reproductive function, and lifespan in aging mice
  Samantha M. Solon-Biet, Kirsty A. Walters, Ulla K. Simanainen, Aisling C. McMahon, Kari Ruohonen, John William O. Ballard, David Raubenheimer, David J. Handelsman, David G. Le Couteur, and Stephen J. Simpson
  
  PNAS March 17, 2015 112 (11) 3481-3486; first published March 2, 2015. https://doi.org/10.1073/pnas.1422041112
- Open Access
  Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption
  Lei Xiong, Ji-Ung Jung, Haitao Wu, Wen-Fang Xia, Jin-Xiu Pan, Chengyong Shen, Lin Mei, and Wen-Cheng Xiong
  
  PNAS March 17, 2015 112 (11) 3487-3492; first published March 2, 2015. https://doi.org/10.1073/pnas.1419714112
- Open Access
  PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
  Helen Y. Zou, Qiuhua Li, Lars D. Engstrom, Melissa West, Vicky Appleman, Katy A. Wong, Michele McTigue, Ya-Li Deng, Wei Liu, Alexei Brooun, Sergei Timofeevski, Scott R. P. McDonnell, Ping Jiang, Matthew D. Falk, Patrick B. Lappin, Timothy Affolter, Tim Nichols, Wenyue Hu, Justine Lam, Ted W. Johnson, Tod Smeal, Al Charest, and Valeria R. Fantin
  
  PNAS March 17, 2015 112 (11) 3493-3498; first published March 2, 2015. https://doi.org/10.1073/pnas.1420785112
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  p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling
  Elisa Maria Memmi, Anna Giulia Sanarico, Arianna Giacobbe, Angelo Peschiaroli, Valentina Frezza, Angelo Cicalese, Federica Pisati, Daniela Tosoni, Huiqing Zhou, Giovanni Tonon, Alexey Antonov, Gerry Melino, Pier Giuseppe Pelicci, and Francesca Bernassola
  
  PNAS March 17, 2015 112 (11) 3499-3504; first published March 4, 2015. https://doi.org/10.1073/pnas.1500762112
Microbiology
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  Disentangling mechanisms that mediate the balance between stochastic and deterministic processes in microbial succession
  Francisco Dini-Andreote, James C. Stegen, Jan Dirk van Elsas, and Joana Falcão Salles
  
  PNAS March 17, 2015 112 (11) E1326-E1332; first published March 2, 2015. https://doi.org/10.1073/pnas.1414261112
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  NFκB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responses
  Mauro Di Pilato, Ernesto Mejías-Pérez, Manuela Zonca, Beatriz Perdiguero, Carmen Elena Gómez, Marianna Trakala, Jacobo Nieto, José Luis Nájera, Carlos Oscar S. Sorzano, Christophe Combadière, Giuseppe Pantaleo, Lourdes Planelles, and Mariano Esteban
  
  PNAS March 17, 2015 112 (11) E1333-E1342; first published March 4, 2015. https://doi.org/10.1073/pnas.1424341112
- Open Access
  Origin of the HIV-1 group O epidemic in western lowland gorillas
  Mirela D’arc, Ahidjo Ayouba, Amandine Esteban, Gerald H. Learn, Vanina Boué, Florian Liegeois, Lucie Etienne, Nikki Tagg, Fabian H. Leendertz, Christophe Boesch, Nadège F. Madinda, Martha M. Robbins, Maryke Gray, Amandine Cournil, Marcel Ooms, Michael Letko, Viviana A. Simon, Paul M. Sharp, Beatrice H. Hahn, Eric Delaporte, Eitel Mpoudi Ngole, and Martine Peeters
  
  PNAS March 17, 2015 112 (11) E1343-E1352; first published March 2, 2015. https://doi.org/10.1073/pnas.1502022112
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  Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation
  Yongqiang Gou, Hyewon Byun, Adam E. Zook, Gurvani B. Singh, Andrea K. Nash, Mary M. Lozano, and Jaquelin P. Dudley
  
  PNAS March 17, 2015 112 (11) 3505-3510; first published March 3, 2015. https://doi.org/10.1073/pnas.1420477112
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  AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity
  Jessica M. A. Blair, Vassiliy N. Bavro, Vito Ricci, Niraj Modi, Pierpaolo Cacciotto, Ulrich Kleinekathӧfer, Paolo Ruggerone, Attilio V. Vargiu, Alison J. Baylay, Helen E. Smith, Yvonne Brandon, David Galloway, and Laura J. V. Piddock
  
  PNAS March 17, 2015 112 (11) 3511-3516; first published March 3, 2015. https://doi.org/10.1073/pnas.1419939112
Neuroscience
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  Disruption of hierarchical predictive coding during sleep
  Melanie Strauss, Jacobo D. Sitt, Jean-Remi King, Maxime Elbaz, Leila Azizi, Marco Buiatti, Lionel Naccache, Virginie van Wassenhove, and Stanislas Dehaene
  
  PNAS March 17, 2015 112 (11) E1353-E1362; first published March 3, 2015. https://doi.org/10.1073/pnas.1501026112
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  Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release
  Katharina Held, Tatjana Kichko, Katrien De Clercq, Hugo Klaassen, Rieta Van Bree, Jean-Christophe Vanherck, Arnaud Marchand, Peter W. Reeh, Patrick Chaltin, Thomas Voets, and Joris Vriens
  
  PNAS March 17, 2015 112 (11) E1363-E1372; first published March 2, 2015. https://doi.org/10.1073/pnas.1419845112
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  Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
  Wuyang Wang, Qiong Gao, Meimei Yang, Xiaoli Zhang, Lu Yu, Maria Lawas, Xinran Li, Marthe Bryant-Genevier, Noel T. Southall, Juan Marugan, Marc Ferrer, and Haoxing Xu
  
  PNAS March 17, 2015 112 (11) E1373-E1381; first published March 2, 2015. https://doi.org/10.1073/pnas.1419669112
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  Coding principles of the canonical cortical microcircuit in the avian brain
  From the Cover
  
  Ana Calabrese and Sarah M. N. Woolley
  
  PNAS March 17, 2015 112 (11) 3517-3522; first published February 17, 2015. https://doi.org/10.1073/pnas.1408545112
  
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  Cortical computation in mammals and birds
  - Mar 09, 2015
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  KCC2 activity is critical in limiting the onset and severity of status epilepticus
  Liliya Silayeva, Tarek Z. Deeb, Rochelle M. Hines, Matt R. Kelley, Michaelanne B. Munoz, Henry H. C. Lee, Nicholas J. Brandon, John Dunlop, Jaime Maguire, Paul A. Davies, and Stephen J. Moss
  
  PNAS March 17, 2015 112 (11) 3523-3528; first published March 2, 2015. https://doi.org/10.1073/pnas.1415126112
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  Stochastic transitions into silence cause noise correlations in cortical circuits
  Gabriela Mochol, Ainhoa Hermoso-Mendizabal, Shuzo Sakata, Kenneth D. Harris, and Jaime de la Rocha
  
  PNAS March 17, 2015 112 (11) 3529-3534; first published March 4, 2015. https://doi.org/10.1073/pnas.1410509112
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  Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations
  Tae Kim, Stephen Thankachan, James T. McKenna, James M. McNally, Chun Yang, Jee Hyun Choi, Lichao Chen, Bernat Kocsis, Karl Deisseroth, Robert E. Strecker, Radhika Basheer, Ritchie E. Brown, and Robert W. McCarley
  
  PNAS March 17, 2015 112 (11) 3535-3540; first published March 2, 2015. https://doi.org/10.1073/pnas.1413625112
- Open Access
  Modeling memory consolidation during posttraining periods in cerebellovestibular learning
  Tadashi Yamazaki, Soichi Nagao, William Lennon, and Shigeru Tanaka
  
  PNAS March 17, 2015 112 (11) 3541-3546; first published March 3, 2015. https://doi.org/10.1073/pnas.1413798112
Pharmacology
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  Glutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cells
  Yifan Hong, Yau-Tsz Lai, Godfrey Chi-Fung Chan, and Hongzhe Sun
  
  PNAS March 17, 2015 112 (11) 3211-3216; first published March 3, 2015. https://doi.org/10.1073/pnas.1421002112
  
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  Systems pharmacology for metallodrugs
  - Mar 30, 2015
Physiology
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  Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17β is mediated by a PKC–ERK1/2–mTOR signaling pathway
  Yuxiang Wang, Liyin Zhu, Satu Kuokkanen, and Jeffrey W. Pollard
  
  PNAS March 17, 2015 112 (11) E1382-E1391; first published March 2, 2015. https://doi.org/10.1073/pnas.1418973112
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  Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels
  Christian J. Peters, Haibo Yu, Jason Tien, Yuh Nung Jan, Min Li, and Lily Yeh Jan
  
  PNAS March 17, 2015 112 (11) 3547-3552; first published March 2, 2015. https://doi.org/10.1073/pnas.1502291112
Plant Biology
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  Thioredoxin, a master regulator of the tricarboxylic acid cycle in plant mitochondria
  Danilo M. Daloso, Karolin Müller, Toshihiro Obata, Alexandra Florian, Takayuki Tohge, Alexandra Bottcher, Christophe Riondet, Laetitia Bariat, Fernando Carrari, Adriano Nunes-Nesi, Bob B. Buchanan, Jean-Philippe Reichheld, Wagner L. Araújo, and Alisdair R. Fernie
  
  PNAS March 17, 2015 112 (11) E1392-E1400; first published February 2, 2015. https://doi.org/10.1073/pnas.1424840112
  
  See companion article:
  Mitochondrial metabolism regulated by thioredoxin
  - Mar 09, 2015
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  Regulatory link between DNA methylation and active demethylation in Arabidopsis
  Mingguang Lei, Huiming Zhang, Russell Julian, Kai Tang, Shaojun Xie, and Jian-Kang Zhu
  
  PNAS March 17, 2015 112 (11) 3553-3557; first published March 2, 2015. https://doi.org/10.1073/pnas.1502279112
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  Arabidopsis OR proteins are the major posttranscriptional regulators of phytoene synthase in controlling carotenoid biosynthesis
  Xiangjun Zhou, Ralf Welsch, Yong Yang, Daniel Álvarez, Matthias Riediger, Hui Yuan, Tara Fish, Jiping Liu, Theodore W. Thannhauser, and Li Li
  
  PNAS March 17, 2015 112 (11) 3558-3563; first published February 9, 2015. https://doi.org/10.1073/pnas.1420831112
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  Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone
  Spencer M. Whitney, Rosemary Birch, Celine Kelso, Jennifer L. Beck, and Maxim V. Kapralov
  
  PNAS March 17, 2015 112 (11) 3564-3569; first published March 2, 2015. https://doi.org/10.1073/pnas.1420536112
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  Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system
  Kabin Xie, Bastian Minkenberg, and Yinong Yang
  
  PNAS March 17, 2015 112 (11) 3570-3575; first published March 2, 2015. https://doi.org/10.1073/pnas.1420294112
Systems Biology
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  Rare variants in neuronal excitability genes influence risk for bipolar disorder
  Seth A. Ament, Szabolcs Szelinger, Gustavo Glusman, Justin Ashworth, Liping Hou, Nirmala Akula, Tatyana Shekhtman, Judith A. Badner, Mary E. Brunkow, Denise E. Mauldin, Anna-Barbara Stittrich, Katherine Rouleau, Sevilla D. Detera-Wadleigh, John I. Nurnberger Jr., Howard J. Edenberg, Elliot S. Gershon, Nicholas Schork, The Bipolar Genome Study, Nathan D. Price, Richard Gelinas, Leroy Hood, David Craig, Francis J. McMahon, John R. Kelsoe, and Jared C. Roach
  
  PNAS March 17, 2015 112 (11) 3576-3581; first published February 17, 2015. https://doi.org/10.1073/pnas.1424958112

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Correction for Bartesaghi et al., Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells
PNAS March 17, 2015 112 (11) E1401; first published February 20, 2015. https://doi.org/10.1073/pnas.1503132112

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