Table of Contents

Biological Sciences

• Agricultural Sciences

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    Global trends in antimicrobial use in food animals

    • From the Cover

    Thomas P. Van Boeckel, Charles Brower, Marius Gilbert, Bryan T. Grenfell, Simon A. Levin, Timothy P. Robinson, Aude Teillant, and Ramanan Laxminarayan

    PNAS May 5, 2015 112 (18) 5649-5654; first published March 19, 2015. https://doi.org/10.1073/pnas.1503141112

    See companion article:

    • Ominous projections for global antibiotic use in food-animal production

      - May 05, 2015

• Anthropology

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    Covariation between human pelvis shape, stature, and head size alleviates the obstetric dilemma

    Barbara Fischer and Philipp Mitteroecker

    PNAS May 5, 2015 112 (18) 5655-5660; first published April 20, 2015. https://doi.org/10.1073/pnas.1420325112

    See companion article:

    • Reply to Underdown and Oppenheimer: Roles of selection, plasticity, and genetics in the integration of human pelvis shape and head size

      - Jan 19, 2016

• Applied Biological Sciences

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    siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown

    Pratik S. Randeria, Mark A. Seeger, Xiao-Qi Wang, Heather Wilson, Desmond Shipp, Chad A. Mirkin, and Amy S. Paller

    PNAS May 5, 2015 112 (18) 5573-5578; first published April 20, 2015. https://doi.org/10.1073/pnas.1505951112

• Biochemistry

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    Sec17 can trigger fusion of trans-SNARE paired membranes without Sec18

    Michael Zick, Amy Orr, Matthew L. Schwartz, Alexey J. Merz, and William T. Wickner

    PNAS May 5, 2015 112 (18) E2290-E2297; first published April 20, 2015. https://doi.org/10.1073/pnas.1506409112
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    Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus

    Jeng-Yeong Chow, Bo-Xue Tian, Gurusankar Ramamoorthy, Brandan S. Hillerich, Ronald D. Seidel, Steven C. Almo, Matthew P. Jacobson, and C. Dale Poulter

    PNAS May 5, 2015 112 (18) 5661-5666; first published April 21, 2015. https://doi.org/10.1073/pnas.1505127112
  • Open Access

    Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis

    • From the Cover

    Janice Ortega, Jessie Y. Li, Sanghee Lee, Dan Tong, Liya Gu, and Guo-Min Li

    PNAS May 5, 2015 112 (18) 5667-5672; first published March 30, 2015. https://doi.org/10.1073/pnas.1417711112

    See companion article:

    • EGFR inhibits DNA mismatch repair

      - May 05, 2015
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    Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer

    Ryszard Michalczyk, Clifford J. Unkefer, John-Paul Bacik, Tobias E. Schrader, Andreas Ostermann, Andrey Y. Kovalevsky, Robert McKenna, and Suzanne Zoë Fisher

    PNAS May 5, 2015 112 (18) 5673-5678; first published April 20, 2015. https://doi.org/10.1073/pnas.1502255112
  • Open Access

    Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display

    Pradeep M. Nair, Heather Flores, Alvin Gogineni, Scot Marsters, David A. Lawrence, Robert F. Kelley, Hai Ngu, Meredith Sagolla, Laszlo Komuves, Richard Bourgon, Jeffrey Settleman, and Avi Ashkenazi

    PNAS May 5, 2015 112 (18) 5679-5684; first published April 20, 2015. https://doi.org/10.1073/pnas.1418962112
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    Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I

    Katarzyna Kmita, Christophe Wirth, Judith Warnau, Sergio Guerrero-Castillo, Carola Hunte, Gerhard Hummer, Ville R. I. Kaila, Klaus Zwicker, Ulrich Brandt, and Volker Zickermann

    PNAS May 5, 2015 112 (18) 5685-5690; first published April 20, 2015. https://doi.org/10.1073/pnas.1424353112
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    pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

    Kevin W. Tipping, Theodoros K. Karamanos, Toral Jakhria, Matthew G. Iadanza, Sophia C. Goodchild, Roman Tuma, Neil A. Ranson, Eric W. Hewitt, and Sheena E. Radford

    PNAS May 5, 2015 112 (18) 5691-5696; first published April 20, 2015. https://doi.org/10.1073/pnas.1423174112

• Biophysics and Computational Biology

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    Inferring epigenetic dynamics from kin correlations

    Sahand Hormoz, Nicolas Desprat, and Boris I. Shraiman

    PNAS May 5, 2015 112 (18) E2281-E2289; first published April 22, 2015. https://doi.org/10.1073/pnas.1504407112
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    Highly polarized C-terminal transition state of the leucine-rich repeat domain of PP32 is governed by local stability

    Thuy Phuong Dao, Ananya Majumdar, and Doug Barrick

    PNAS May 5, 2015 112 (18) E2298-E2306; first published April 20, 2015. https://doi.org/10.1073/pnas.1412165112
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    Designing multivalent probes for tunable superselective targeting

    Galina V. Dubacheva, Tine Curk, Rachel Auzély-Velty, Daan Frenkel, and Ralf P. Richter

    PNAS May 5, 2015 112 (18) 5579-5584; first published April 21, 2015. https://doi.org/10.1073/pnas.1500622112
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    Two-sided block of a dual-topology F⁻ channel

    Daniel L. Turman, Jacob T. Nathanson, Randy B. Stockbridge, Timothy O. Street, and Christopher Miller

    PNAS May 5, 2015 112 (18) 5697-5701; first published April 20, 2015. https://doi.org/10.1073/pnas.1505301112
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    Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation

    Daniel G. Isom and Henrik G. Dohlman

    PNAS May 5, 2015 112 (18) 5702-5707; first published April 20, 2015. https://doi.org/10.1073/pnas.1417888112

• Cell Biology

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    The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo

    Judith M. Neugebauer, Sunjong Kwon, Hyung-Seok Kim, Nathan Donley, Anup Tilak, Shailaja Sopory, and Jan L. Christian

    PNAS May 5, 2015 112 (18) E2307-E2316; first published April 20, 2015. https://doi.org/10.1073/pnas.1501449112
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    Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells

    Claudia Cattoglio, Elisa T. Zhang, Ivan Grubisic, Kunitoshi Chiba, Yick W. Fong, and Robert Tjian

    PNAS May 5, 2015 112 (18) E2317-E2326; first published April 21, 2015. https://doi.org/10.1073/pnas.1505569112
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    Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

    Asaf Rotem, Andreas Janzer, Benjamin Izar, Zhe Ji, John G. Doench, Levi A. Garraway, and Kevin Struhl

    PNAS May 5, 2015 112 (18) 5708-5713; first published April 20, 2015. https://doi.org/10.1073/pnas.1505979112
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    Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I_Ks channel

    Sara I. Liin, Malin Silverå Ejneby, Rene Barro-Soria, Mark Alexander Skarsfeldt, Johan E. Larsson, Frida Starck Härlin, Teija Parkkari, Bo Hjorth Bentzen, Nicole Schmitt, H. Peter Larsson, and Fredrik Elinder

    PNAS May 5, 2015 112 (18) 5714-5719; first published April 21, 2015. https://doi.org/10.1073/pnas.1503488112
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    Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell

    Srujana Neelam, T. J. Chancellor, Yuan Li, Jeffrey A. Nickerson, Kyle J. Roux, Richard B. Dickinson, and Tanmay P. Lele

    PNAS May 5, 2015 112 (18) 5720-5725; first published April 21, 2015. https://doi.org/10.1073/pnas.1502111112

• Developmental Biology

  • Open Access

    During Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay

    Tomonori Katsuyama, Federico Comoglio, Makiko Seimiya, Erik Cabuy, and Renato Paro

    PNAS May 5, 2015 112 (18) E2327-E2336; first published April 20, 2015. https://doi.org/10.1073/pnas.1423074112
  • Open Access

    Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure

    Ying Yang, Katsuyuki Adachi, Megan A. Sheridan, Andrei P. Alexenko, Danny J. Schust, Laura C. Schulz, Toshihiko Ezashi, and R. Michael Roberts

    PNAS May 5, 2015 112 (18) E2337-E2346; first published April 13, 2015. https://doi.org/10.1073/pnas.1504778112
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    Periodic retinoic acid–STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis

    Tsutomu Endo, Katherine A. Romer, Ericka L. Anderson, Andrew E. Baltus, Dirk G. de Rooij, and David C. Page

    PNAS May 5, 2015 112 (18) E2347-E2356; first published April 20, 2015. https://doi.org/10.1073/pnas.1505683112
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    Emergence of homeostatic epithelial packing and stress dissipation through divisions oriented along the long cell axis

    Tom P. J. Wyatt, Andrew R. Harris, Maxine Lam, Qian Cheng, Julien Bellis, Andrea Dimitracopoulos, Alexandre J. Kabla, Guillaume T. Charras, and Buzz Baum

    PNAS May 5, 2015 112 (18) 5726-5731; first published April 23, 2015. https://doi.org/10.1073/pnas.1420585112
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    Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis

    Ya-Lin Huang, Zeinab Anvarian, Gabriele Döderlein, Sergio P. Acebron, and Christof Niehrs

    PNAS May 5, 2015 112 (18) 5732-5737; first published April 21, 2015. https://doi.org/10.1073/pnas.1423533112

• Ecology

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    Biodiversity influences plant productivity through niche–efficiency

    Jingjing Liang, Mo Zhou, Patrick C. Tobin, A. David McGuire, and Peter B. Reich

    PNAS May 5, 2015 112 (18) 5738-5743; first published April 21, 2015. https://doi.org/10.1073/pnas.1409853112
  • Open Access

    Predicting plant vulnerability to drought in biodiverse regions using functional traits

    Robert Paul Skelton, Adam G. West, and Todd E. Dawson

    PNAS May 5, 2015 112 (18) 5744-5749; first published April 20, 2015. https://doi.org/10.1073/pnas.1503376112

• Environmental Sciences

  • Open Access

    Agricultural insecticides threaten surface waters at the global scale

    Sebastian Stehle and Ralf Schulz

    PNAS May 5, 2015 112 (18) 5750-5755; first published April 13, 2015. https://doi.org/10.1073/pnas.1500232112
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    Continental-scale distributions of dust-associated bacteria and fungi

    Albert Barberán, Joshua Ladau, Jonathan W. Leff, Katherine S. Pollard, Holly L. Menninger, Robert R. Dunn, and Noah Fierer

    PNAS May 5, 2015 112 (18) 5756-5761; first published April 20, 2015. https://doi.org/10.1073/pnas.1420815112
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    Phytoplankton adapt to changing ocean environments

    Andrew J. Irwin, Zoe V. Finkel, Frank E. Müller-Karger, and Luis Troccoli Ghinaglia

    PNAS May 5, 2015 112 (18) 5762-5766; first published April 20, 2015. https://doi.org/10.1073/pnas.1414752112

    See companion article:

    • Reply to Brun et al.: Fingerprint of evolution revealed by shifts in realized phytoplankton niches in natural populations

      - Sep 22, 2015

• Evolution

  • Open Access

    Hybrid apomicts trapped in the ecological niches of their sexual ancestors

    Martin Mau, John T. Lovell, José M. Corral, Christiane Kiefer, Marcus A. Koch, Olawale M. Aliyu, and Timothy F. Sharbel

    PNAS May 5, 2015 112 (18) E2357-E2365; first published April 20, 2015. https://doi.org/10.1073/pnas.1423447112
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    Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate

    Sebastian G. Gornik, Febrimarsa, Andrew M. Cassin, James I. MacRae, Abhinay Ramaprasad, Zineb Rchiad, Malcolm J. McConville, Antony Bacic, Geoffrey I. McFadden, Arnab Pain, and Ross F. Waller

    PNAS May 5, 2015 112 (18) 5767-5772; first published April 20, 2015. https://doi.org/10.1073/pnas.1423400112
  • Open Access

    Error, signal, and the placement of Ctenophora sister to all other animals

    Nathan V. Whelan, Kevin M. Kocot, Leonid L. Moroz, and Kenneth M. Halanych

    PNAS May 5, 2015 112 (18) 5773-5778; first published April 20, 2015. https://doi.org/10.1073/pnas.1503453112

• Genetics

  • Open Access

    Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress

    Zhiji Ren and Victor R. Ambros

    PNAS May 5, 2015 112 (18) E2366-E2375; first published April 20, 2015. https://doi.org/10.1073/pnas.1422858112
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    Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system

    Ruth Stuckey, Néstor García-Rodríguez, Andrés Aguilera, and Ralf Erik Wellinger

    PNAS May 5, 2015 112 (18) 5779-5784; first published April 20, 2015. https://doi.org/10.1073/pnas.1501769112
  • Open Access

    Head-to-head antisense transcription and R-loop formation promotes transcriptional activation

    Raquel Boque-Sastre, Marta Soler, Cristina Oliveira-Mateos, Anna Portela, Catia Moutinho, Sergi Sayols, Alberto Villanueva, Manel Esteller, and Sonia Guil

    PNAS May 5, 2015 112 (18) 5785-5790; first published April 22, 2015. https://doi.org/10.1073/pnas.1421197112

• Immunology and Inflammation

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    NK cells require IL-28R for optimal in vivo activity

    Fernando Souza-Fonseca-Guimaraes, Arabella Young, Deepak Mittal, Ludovic Martinet, Claudia Bruedigam, Kazuyoshi Takeda, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Geoffrey R. Hill, and Mark J. Smyth

    PNAS May 5, 2015 112 (18) E2376-E2384; first published April 21, 2015. https://doi.org/10.1073/pnas.1424241112
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    Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs

    Benjamin M. Fiebiger, Jad Maamary, Andrew Pincetic, and Jeffrey V. Ravetch

    PNAS May 5, 2015 112 (18) E2385-E2394; first published April 13, 2015. https://doi.org/10.1073/pnas.1505292112
  • Open Access

    Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase

    Wenjun Hu, Nasim A. Begum, Samiran Mondal, Andre Stanlie, and Tasuku Honjo

    PNAS May 5, 2015 112 (18) 5791-5796; first published April 20, 2015. https://doi.org/10.1073/pnas.1506167112
  • Open Access

    Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

    Gregor Ebert, Simon Preston, Cody Allison, James Cooney, Jesse G. Toe, Michael D. Stutz, Samar Ojaimi, Hamish W. Scott, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, Ruth Chin, Danielle Colledge, Xin Li, Nadia Warner, Peter Revill, Scott Bowden, John Silke, C. Glenn Begley, and Marc Pellegrini

    PNAS May 5, 2015 112 (18) 5797-5802; first published April 20, 2015. https://doi.org/10.1073/pnas.1502390112

    See companion article:

    • Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

      - May 05, 2015
  • Open Access

    Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

    Gregor Ebert, Cody Allison, Simon Preston, James Cooney, Jesse G. Toe, Michael D. Stutz, Samar Ojaimi, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, John Silke, C. Glenn Begley, and Marc Pellegrini

    PNAS May 5, 2015 112 (18) 5803-5808; first published April 20, 2015. https://doi.org/10.1073/pnas.1502400112

    See companion article:

    • Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

      - May 05, 2015
  • Open Access

    Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation

    Miki Yamamoto-Hino, Masatoshi Muraoka, Shu Kondo, Ryu Ueda, Hideyuki Okano, and Satoshi Goto

    PNAS May 5, 2015 112 (18) 5809-5814; first published April 21, 2015. https://doi.org/10.1073/pnas.1424514112

• Medical Sciences

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    Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

    • From the Cover

    Yali Jia, Steven T. Bailey, Thomas S. Hwang, Scott M. McClintic, Simon S. Gao, Mark E. Pennesi, Christina J. Flaxel, Andreas K. Lauer, David J. Wilson, Joachim Hornegger, James G. Fujimoto, and David Huang

    PNAS May 5, 2015 112 (18) E2395-E2402; first published April 20, 2015. https://doi.org/10.1073/pnas.1500185112
  • Open Access

    Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice

    Catherine K. Hathaway, Adil M. H. Gasim, Ruriko Grant, Albert S. Chang, Hyung-Suk Kim, Victoria J. Madden, C. Robert Bagnell Jr., J. Charles Jennette, Oliver Smithies, and Masao Kakoki

    PNAS May 5, 2015 112 (18) 5815-5820; first published April 20, 2015. https://doi.org/10.1073/pnas.1504777112

• Neuroscience

  • Open Access

    Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments

    Kyoung-hye Yoon, Tobias Ragoczy, Zhonghua Lu, Kunio Kondoh, Donghui Kuang, Mark Groudine, and Linda B. Buck

    PNAS May 5, 2015 112 (18) E2403-E2409; first published April 20, 2015. https://doi.org/10.1073/pnas.1506058112
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    Odorant receptors regulate the final glomerular coalescence of olfactory sensory neuron axons

    Diego J. Rodriguez-Gil, Dianna L. Bartel, Austin W. Jaspers, Arie S. Mobley, Fumiaki Imamura, and Charles A. Greer

    PNAS May 5, 2015 112 (18) 5821-5826; first published April 20, 2015. https://doi.org/10.1073/pnas.1417955112

• Physiology

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    Essential role of Orai1 store-operated calcium channels in lactation

    Felicity M. Davis, Agnes Janoshazi, Kyathanahalli S. Janardhan, Natacha Steinckwich, Diane M. D’Agostin, John G. Petranka, Pooja N. Desai, Sarah J. Roberts-Thomson, Gary S. Bird, Deirdre K. Tucker, Suzanne E. Fenton, Stefan Feske, Gregory R. Monteith, and James W. Putney Jr.

    PNAS May 5, 2015 112 (18) 5827-5832; first published April 20, 2015. https://doi.org/10.1073/pnas.1502264112

• Plant Biology

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    The resurrection genome of Boea hygrometrica: A blueprint for survival of dehydration

    Lihong Xiao, Ge Yang, Liechi Zhang, Xinhua Yang, Shuang Zhao, Zhongzhong Ji, Qing Zhou, Min Hu, Yu Wang, Ming Chen, Yu Xu, Haijing Jin, Xuan Xiao, Guipeng Hu, Fang Bao, Yong Hu, Ping Wan, Legong Li, Xin Deng, Tingyun Kuang, Chengbin Xiang, Jian-Kang Zhu, Melvin J. Oliver, and Yikun He

    PNAS May 5, 2015 112 (18) 5833-5837; first published April 20, 2015. https://doi.org/10.1073/pnas.1505811112
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    Cell growth defect factor 1 is crucial for the plastid import of NADPH:protochlorophyllide oxidoreductase A in Arabidopsis thaliana

    Steffen Reinbothe, John Gray, Sachin Rustgi, Diter von Wettstein, and Christiane Reinbothe

    PNAS May 5, 2015 112 (18) 5838-5843; first published April 21, 2015. https://doi.org/10.1073/pnas.1506339112
  • Open Access

    The genome of cultivated sweet potato contains Agrobacterium T-DNAs with expressed genes: An example of a naturally transgenic food crop

    • From the Cover

    Tina Kyndt, Dora Quispe, Hong Zhai, Robert Jarret, Marc Ghislain, Qingchang Liu, Godelieve Gheysen, and Jan F. Kreuze

    PNAS May 5, 2015 112 (18) 5844-5849; first published April 20, 2015. https://doi.org/10.1073/pnas.1419685112
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    Phytophthora effector targets a novel component of small RNA pathway in plants to promote infection

    Yongli Qiao, Jinxia Shi, Yi Zhai, Yingnan Hou, and Wenbo Ma

    PNAS May 5, 2015 112 (18) 5850-5855; first published April 20, 2015. https://doi.org/10.1073/pnas.1421475112

• Psychological and Cognitive Sciences

  • Open Access

    The amplification of risk in experimental diffusion chains

    Mehdi Moussaïd, Henry Brighton, and Wolfgang Gaissmaier

    PNAS May 5, 2015 112 (18) 5631-5636; first published April 20, 2015. https://doi.org/10.1073/pnas.1421883112