Table of Contents

Biological Sciences

• Agricultural Sciences

  • Open Access

    Chemical messages in 170-year-old champagne bottles from the Baltic Sea: Revealing tastes from the past

    Philippe Jeandet, Silke S. Heinzmann, Chloé Roullier-Gall, Clara Cilindre, Alissa Aron, Marie Alice Deville, Franco Moritz, Thomas Karbowiak, Dominique Demarville, Cyril Brun, Fabienne Moreau, Bernhard Michalke, Gérard Liger-Belair, Michael Witting, Marianna Lucio, Damien Steyer, Régis D. Gougeon, and Philippe Schmitt-Kopplin

    PNAS May 12, 2015 112 (19) 5893-5898; first published April 20, 2015. https://doi.org/10.1073/pnas.1500783112

• Applied Biological Sciences

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    Injury alters intrinsic functional connectivity within the primate spinal cord

    Li Min Chen, Arabinda Mishra, Pai-Feng Yang, Feng Wang, and John C. Gore

    PNAS May 12, 2015 112 (19) 5991-5996; first published April 22, 2015. https://doi.org/10.1073/pnas.1424106112
  • Open Access

    Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

    Angela Schoch, Hubert Kettenberger, Olaf Mundigl, Gerhard Winter, Julia Engert, Julia Heinrich, and Thomas Emrich

    PNAS May 12, 2015 112 (19) 5997-6002; first published April 27, 2015. https://doi.org/10.1073/pnas.1408766112

• Biochemistry

  • Open Access

    Structural basis of human γ-secretase assembly

    Linfeng Sun, Lingyun Zhao, Guanghui Yang, Chuangye Yan, Rui Zhou, Xiaoyuan Zhou, Tian Xie, Yanyu Zhao, Shenjie Wu, Xueming Li, and Yigong Shi

    PNAS May 12, 2015 112 (19) 6003-6008; first published April 27, 2015. https://doi.org/10.1073/pnas.1506242112
  • Open Access

    How release of phosphate from mammalian F₁-ATPase generates a rotary substep

    John V. Bason, Martin G. Montgomery, Andrew G. W. Leslie, and John E. Walker

    PNAS May 12, 2015 112 (19) 6009-6014; first published April 27, 2015. https://doi.org/10.1073/pnas.1506465112
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    Nonsense suppression in archaea

    Arpita Bhattacharya, Caroline Köhrer, Debabrata Mandal, and Uttam L. RajBhandary

    PNAS May 12, 2015 112 (19) 6015-6020; first published April 27, 2015. https://doi.org/10.1073/pnas.1501558112
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    A ΩXaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence

    Normand Cyr, Cynthia de la Fuente, Lauriane Lecoq, Irene Guendel, Philippe R. Chabot, Kylene Kehn-Hall, and James G. Omichinski

    PNAS May 12, 2015 112 (19) 6021-6026; first published April 27, 2015. https://doi.org/10.1073/pnas.1503688112
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    Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation

    Ziwei Liu, Oscar Vargas-Rodriguez, Yuki Goto, Eva Maria Novoa, Lluís Ribas de Pouplana, Hiroaki Suga, and Karin Musier-Forsyth

    PNAS May 12, 2015 112 (19) 6027-6032; first published April 27, 2015. https://doi.org/10.1073/pnas.1423664112
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    Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases

    Robert T. Byrne, Huw T. Jenkins, Daniel T. Peters, Fiona Whelan, James Stowell, Naveed Aziz, Pavel Kasatsky, Marina V. Rodnina, Eugene V. Koonin, Andrey L. Konevega, and Alfred A. Antson

    PNAS May 12, 2015 112 (19) 6033-6037; first published April 22, 2015. https://doi.org/10.1073/pnas.1500161112
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    The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center

    Michael T. Englander, Joshua L. Avins, Rachel C. Fleisher, Bo Liu, Philip R. Effraim, Jiangning Wang, Klaus Schulten, Thomas S. Leyh, Ruben L. Gonzalez Jr., and Virginia W. Cornish

    PNAS May 12, 2015 112 (19) 6038-6043; first published April 27, 2015. https://doi.org/10.1073/pnas.1424712112
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    Crystal structure of the human mitochondrial chaperonin symmetrical football complex

    Shahar Nisemblat, Oren Yaniv, Avital Parnas, Felix Frolow, and Abdussalam Azem

    PNAS May 12, 2015 112 (19) 6044-6049; first published April 27, 2015. https://doi.org/10.1073/pnas.1411718112
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    Diabetes-associated dysregulation of O-GlcNAcylation in rat cardiac mitochondria

    Partha S. Banerjee, Junfeng Ma, and Gerald W. Hart

    PNAS May 12, 2015 112 (19) 6050-6055; first published April 27, 2015. https://doi.org/10.1073/pnas.1424017112
  • Open Access

    A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL

    Yi Xing, Stefan L. Oliver, TuongVi Nguyen, Claudio Ciferri, Avishek Nandi, Julie Hickman, Cinzia Giovani, Edward Yang, Giuseppe Palladino, Charles Grose, Yasushi Uematsu, Anders E. Lilja, Ann M. Arvin, and Andrea Carfí

    PNAS May 12, 2015 112 (19) 6056-6061; first published April 27, 2015. https://doi.org/10.1073/pnas.1501176112

• Biophysics and Computational Biology

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    Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure

    Michael T. Lerch, Carlos J. López, Zhongyu Yang, Margaux J. Kreitman, Joseph Horwitz, and Wayne L. Hubbell

    PNAS May 12, 2015 112 (19) E2437-E2446; first published April 27, 2015. https://doi.org/10.1073/pnas.1506505112
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    Architecture and migration of an epithelium on a cylindrical wire

    Hannah G. Yevick, Guillaume Duclos, Isabelle Bonnet, and Pascal Silberzan

    PNAS May 12, 2015 112 (19) 5944-5949; first published April 28, 2015. https://doi.org/10.1073/pnas.1418857112
  • Open Access

    How a well-adapted immune system is organized

    Andreas Mayer, Vijay Balasubramanian, Thierry Mora, and Aleksandra M. Walczak

    PNAS May 12, 2015 112 (19) 5950-5955; first published April 27, 2015. https://doi.org/10.1073/pnas.1421827112
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    Topology, structures, and energy landscapes of human chromosomes

    Bin Zhang and Peter G. Wolynes

    PNAS May 12, 2015 112 (19) 6062-6067; first published April 27, 2015. https://doi.org/10.1073/pnas.1506257112
  • Open Access

    Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite

    Yao Zhang, Changjin Huang, Sangtae Kim, Mahdi Golkaram, Matthew W. A. Dixon, Leann Tilley, Ju Li, Sulin Zhang, and Subra Suresh

    PNAS May 12, 2015 112 (19) 6068-6073; first published April 27, 2015. https://doi.org/10.1073/pnas.1505584112

• Cell Biology

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    Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly

    Colleen T. Skau, Sergey V. Plotnikov, Andrew D. Doyle, and Clare M. Waterman

    PNAS May 12, 2015 112 (19) E2447-E2456; first published April 27, 2015. https://doi.org/10.1073/pnas.1505035112
  • Open Access

    CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation

    • Inaugural Article

    Masahiro Shuda, Celestino Velásquez, Erdong Cheng, Daniel G. Cordek, Hyun Jin Kwun, Yuan Chang, and Patrick S. Moore

    PNAS May 12, 2015 112 (19) 5875-5882; first published April 16, 2015. https://doi.org/10.1073/pnas.1505787112

    See companion article:

    • QnAs with Patrick Moore

      - May 12, 2015
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    Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis

    Jun Hong Park, Hong-Jun Kang, Yun Kyung Lee, Hyeog Kang, Jihyun Kim, Jay H. Chung, Ji Suk Chang, Alexandra C. McPherron, and Sean Bong Lee

    PNAS May 12, 2015 112 (19) 6074-6079; first published April 27, 2015. https://doi.org/10.1073/pnas.1504391112

• Developmental Biology

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    iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

    Xue Li, Thorsten Maretzky, Gisela Weskamp, Sébastien Monette, Xiaoping Qing, Priya Darshinee A. Issuree, Howard C. Crawford, David R. McIlwain, Tak W. Mak, Jane E. Salmon, and Carl P. Blobel

    PNAS May 12, 2015 112 (19) 6080-6085; first published April 27, 2015. https://doi.org/10.1073/pnas.1505649112
  • Open Access

    Neural crest cell-derived VEGF promotes embryonic jaw extension

    Sophie Wiszniak, Francesca E. Mackenzie, Peter Anderson, Samuela Kabbara, Christiana Ruhrberg, and Quenten Schwarz

    PNAS May 12, 2015 112 (19) 6086-6091; first published April 28, 2015. https://doi.org/10.1073/pnas.1419368112

• Ecology

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    Environmental constraints drive the partitioning of the soundscape in fishes

    • From the Cover

    Laëtitia Ruppé, Gaël Clément, Anthony Herrel, Laurent Ballesta, Thierry Décamps, Loïc Kéver, and Eric Parmentier

    PNAS May 12, 2015 112 (19) 6092-6097; first published April 6, 2015. https://doi.org/10.1073/pnas.1424667112

    See companion article:

    • Soundscapes offer unique opportunities for studies of fish communities

      - May 12, 2015
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    On the factors that promote the diversity of herbivorous insects and plants in tropical forests

    Judith X. Becerra

    PNAS May 12, 2015 112 (19) 6098-6103; first published April 20, 2015. https://doi.org/10.1073/pnas.1418643112
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    Comparative analyses of animal-tracking data reveal ecological significance of endothermy in fishes

    • From the Cover

    Yuuki Y. Watanabe, Kenneth J. Goldman, Jennifer E. Caselle, Demian D. Chapman, and Yannis P. Papastamatiou

    PNAS May 12, 2015 112 (19) 6104-6109; first published April 20, 2015. https://doi.org/10.1073/pnas.1500316112

• Environmental Sciences

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    Dose-dependent regulation of microbial activity on sinking particles by polyunsaturated aldehydes: Implications for the carbon cycle

    Bethanie R. Edwards, Kay D. Bidle, and Benjamin A. S. Van Mooy

    PNAS May 12, 2015 112 (19) 5909-5914; first published April 27, 2015. https://doi.org/10.1073/pnas.1422664112

• Evolution

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    Reappraisal of hydrocarbon biomarkers in Archean rocks

    Katherine L. French, Christian Hallmann, Janet M. Hope, Petra L. Schoon, J. Alex Zumberge, Yosuke Hoshino, Carl A. Peters, Simon C. George, Gordon D. Love, Jochen J. Brocks, Roger Buick, and Roger E. Summons

    PNAS May 12, 2015 112 (19) 5915-5920; first published April 27, 2015. https://doi.org/10.1073/pnas.1419563112
  • Open Access

    Biological evidence supports an early and complex emergence of the Isthmus of Panama

    Christine D. Bacon, Daniele Silvestro, Carlos Jaramillo, Brian Tilston Smith, Prosanta Chakrabarty, and Alexandre Antonelli

    PNAS May 12, 2015 112 (19) 6110-6115; first published April 27, 2015. https://doi.org/10.1073/pnas.1423853112

    See companion article:

    • Reply to Lessios and Marko et al.: Early and progressive migration across the Isthmus of Panama is robust to missing data and biases

      - Oct 27, 2015

• Genetics

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    dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

    Lindsey N. Williams, Lisette Marjavaara, Gary M. Knowels, Eric M. Schultz, Edward J. Fox, Andrei Chabes, and Alan J. Herr

    PNAS May 12, 2015 112 (19) E2457-E2466; first published March 31, 2015. https://doi.org/10.1073/pnas.1422948112

    See companion article:

    • Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

      - May 12, 2015

    See companion article:

    • Pools and Pols: Mechanism of a mutator phenotype

      - May 12, 2015
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    Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

    Tony M. Mertz, Sushma Sharma, Andrei Chabes, and Polina V. Shcherbakova

    PNAS May 12, 2015 112 (19) E2467-E2476; first published March 31, 2015. https://doi.org/10.1073/pnas.1422934112

    See companion article:

    • dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

      - May 12, 2015

    See companion article:

    • Pools and Pols: Mechanism of a mutator phenotype

      - May 12, 2015
  • You have access

    Transcriptome dynamics of developing maize leaves and genomewide prediction of cis elements and their cognate transcription factors

    Chun-Ping Yu, Sean Chun-Chang Chen, Yao-Ming Chang, Wen-Yu Liu, Hsin-Hung Lin, Jinn-Jy Lin, Hsiang June Chen, Yu-Ju Lu, Yi-Hsuan Wu, Mei-Yeh Jade Lu, Chen-Hua Lu, Arthur Chun-Chieh Shih, Maurice Sun-Ben Ku, Shin-Han Shiu, Shu-Hsing Wu, and Wen-Hsiung Li

    PNAS May 12, 2015 112 (19) E2477-E2486; first published April 27, 2015. https://doi.org/10.1073/pnas.1500605112
  • Open Access

    Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter

    Patrick A. Gibney, Ariel Schieler, Jonathan C. Chen, Joshua D. Rabinowitz, and David Botstein

    PNAS May 12, 2015 112 (19) 6116-6121; first published April 27, 2015. https://doi.org/10.1073/pnas.1506289112

    See companion article:

    • Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae

      - May 12, 2015
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    Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae

    Hugo Tapia, Lindsey Young, Douglas Fox, Carolyn R. Bertozzi, and Douglas Koshland

    PNAS May 12, 2015 112 (19) 6122-6127; first published April 27, 2015. https://doi.org/10.1073/pnas.1506415112

    See companion article:

    • Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter

      - May 12, 2015
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    Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer

    Huiling He, Wei Li, Sandya Liyanarachchi, Mukund Srinivas, Yanqiang Wang, Keiko Akagi, Yao Wang, Dayong Wu, Qianben Wang, Victor Jin, David E. Symer, Rulong Shen, John Phay, Rebecca Nagy, and Albert de la Chapelle

    PNAS May 12, 2015 112 (19) 6128-6133; first published April 27, 2015. https://doi.org/10.1073/pnas.1506255112
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    Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema

    Aastha Mishra, Samantha Kohli, Sanchi Dua, Tashi Thinlas, Ghulam Mohammad, and M. A. Qadar Pasha

    PNAS May 12, 2015 112 (19) 6134-6139; first published April 27, 2015. https://doi.org/10.1073/pnas.1422759112

• Immunology and Inflammation

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    IL-33 activates tumor stroma to promote intestinal polyposis

    Rebecca L. Maywald, Stephanie K. Doerner, Luca Pastorelli, Carlo De Salvo, Susan M. Benton, Emily P. Dawson, Denise G. Lanza, Nathan A. Berger, Sanford D. Markowitz, Heinz-Josef Lenz, Joseph H. Nadeau, Theresa T. Pizarro, and Jason D. Heaney

    PNAS May 12, 2015 112 (19) E2487-E2496; first published April 27, 2015. https://doi.org/10.1073/pnas.1422445112
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    Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients

    Emanuela Romano, Monika Kusio-Kobialka, Periklis G. Foukas, Petra Baumgaertner, Christiane Meyer, Pierluigi Ballabeni, Olivier Michielin, Benjamin Weide, Pedro Romero, and Daniel E. Speiser

    PNAS May 12, 2015 112 (19) 6140-6145; first published April 27, 2015. https://doi.org/10.1073/pnas.1417320112
  • Open Access

    Noninvasive imaging of immune responses

    • From the Cover

    Mohammad Rashidian, Edmund J. Keliher, Angelina M. Bilate, Joao N. Duarte, Gregory R. Wojtkiewicz, Johanne Tracey Jacobsen, Juanjo Cragnolini, Lee Kim Swee, Gabriel D. Victora, Ralph Weissleder, and Hidde L. Ploegh

    PNAS May 12, 2015 112 (19) 6146-6151; first published April 20, 2015. https://doi.org/10.1073/pnas.1502609112

    See companion article:

    • Targeted noninvasive imaging of the innate immune response

      - May 12, 2015

• Medical Sciences

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    Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

    Toshihide Takeuchi, Mari Suzuki, Nobuhiro Fujikake, H. Akiko Popiel, Hisae Kikuchi, Shiroh Futaki, Keiji Wada, and Yoshitaka Nagai

    PNAS May 12, 2015 112 (19) E2497-E2506; first published April 27, 2015. https://doi.org/10.1073/pnas.1412651112
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    Direct conversion of human fibroblasts into functional osteoblasts by defined factors

    Kenta Yamamoto, Tsunao Kishida, Yoshiki Sato, Keisuke Nishioka, Akika Ejima, Hiroyoshi Fujiwara, Toshikazu Kubo, Toshiro Yamamoto, Narisato Kanamura, and Osam Mazda

    PNAS May 12, 2015 112 (19) 6152-6157; first published April 27, 2015. https://doi.org/10.1073/pnas.1420713112

• Microbiology

  • Open Access

    Metabolic and trophic interactions modulate methane production by Arctic peat microbiota in response to warming

    • From the Cover

    Alexander Tøsdal Tveit, Tim Urich, Peter Frenzel, and Mette Marianne Svenning

    PNAS May 12, 2015 112 (19) E2507-E2516; first published April 27, 2015. https://doi.org/10.1073/pnas.1420797112
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    Coral symbiotic algae calcify ex hospite in partnership with bacteria

    Jörg C. Frommlet, Maria L. Sousa, Artur Alves, Sandra I. Vieira, David J. Suggett, and João Serôdio

    PNAS May 12, 2015 112 (19) 6158-6163; first published April 27, 2015. https://doi.org/10.1073/pnas.1420991112
  • Open Access

    Cas9-mediated targeting of viral RNA in eukaryotic cells

    Aryn A. Price, Timothy R. Sampson, Hannah K. Ratner, Arash Grakoui, and David S. Weiss

    PNAS May 12, 2015 112 (19) 6164-6169; first published April 27, 2015. https://doi.org/10.1073/pnas.1422340112

• Neuroscience

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    Targeting β-arrestin2 in the treatment of l-DOPA–induced dyskinesia in Parkinson’s disease

    Nikhil M. Urs, Simone Bido, Sean M. Peterson, Tanya L. Daigle, Caroline E. Bass, Raul R. Gainetdinov, Erwan Bezard, and Marc G. Caron

    PNAS May 12, 2015 112 (19) E2517-E2526; first published April 27, 2015. https://doi.org/10.1073/pnas.1502740112
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    Functional connectivity arises from a slow rhythmic mechanism

    Jingfeng M. Li, William J. Bentley, and Lawrence H. Snyder

    PNAS May 12, 2015 112 (19) E2527-E2535; first published April 27, 2015. https://doi.org/10.1073/pnas.1419837112
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    Histamine in the basolateral amygdala promotes inhibitory avoidance learning independently of hippocampus

    Fernando Benetti, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw, Gustavo Provensi, Maria Beatrice Passani, Elisabetta Baldi, Corrado Bucherelli, Leonardo Munari, Ivan Izquierdo, and Patrizio Blandina

    PNAS May 12, 2015 112 (19) E2536-E2542; first published April 27, 2015. https://doi.org/10.1073/pnas.1506109112
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    Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush

    Laura Elisabeth Wong, Molly E. Gibson, H. Moore Arnold, Blake Pepinsky, and Eric Frank

    PNAS May 12, 2015 112 (19) 6170-6175; first published April 27, 2015. https://doi.org/10.1073/pnas.1502057112
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    Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons

    Olga Varea, Maria Dolores Martin-de-Saavedra, Katherine J. Kopeikina, Britta Schürmann, Hunter J. Fleming, Jessica M. Fawcett-Patel, Anthony Bach, Seil Jang, Elior Peles, Eunjoon Kim, and Peter Penzes

    PNAS May 12, 2015 112 (19) 6176-6181; first published April 27, 2015. https://doi.org/10.1073/pnas.1423205112
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    Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors

    Tae Hee Han, Poorva Dharkar, Mark L. Mayer, and Mihaela Serpe

    PNAS May 12, 2015 112 (19) 6182-6187; first published April 27, 2015. https://doi.org/10.1073/pnas.1500458112
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    Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior

    Jason M. Dwyer, Jaime G. Maldonado-Avilés, Ashley E. Lepack, Ralph J. DiLeone, and Ronald S. Duman

    PNAS May 12, 2015 112 (19) 6188-6193; first published April 27, 2015. https://doi.org/10.1073/pnas.1505289112

• Pharmacology

  • Open Access

    Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor

    Radovan Spurny, Sarah Debaveye, Ana Farinha, Ken Veys, Ann M. Vos, Thomas Gossas, John Atack, Sonia Bertrand, Daniel Bertrand, U. Helena Danielson, Gary Tresadern, and Chris Ulens

    PNAS May 12, 2015 112 (19) E2543-E2552; first published April 27, 2015. https://doi.org/10.1073/pnas.1418289112
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    Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

    Hannah M. Stoveken, Alexander G. Hajduczok, Lei Xu, and Gregory G. Tall

    PNAS May 12, 2015 112 (19) 6194-6199; first published April 27, 2015. https://doi.org/10.1073/pnas.1421785112

• Physiology

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    Modulation of orthogonal body waves enables high maneuverability in sidewinding locomotion

    • From the Cover

    Henry C. Astley, Chaohui Gong, Jin Dai, Matthew Travers, Miguel M. Serrano, Patricio A. Vela, Howie Choset, Joseph R. Mendelson III, David L. Hu, and Daniel I. Goldman

    PNAS May 12, 2015 112 (19) 6200-6205; first published March 23, 2015. https://doi.org/10.1073/pnas.1418965112

    See companion article:

    • Snake robot uncovers secrets to sidewinders’ maneuverability

      - May 12, 2015
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    Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

    Mate Maus, Amit Jairaman, Peter B. Stathopulos, Martin Muik, Marc Fahrner, Carl Weidinger, Melina Benson, Sebastian Fuchs, Stephan Ehl, Christoph Romanin, Mitsuhiko Ikura, Murali Prakriya, and Stefan Feske

    PNAS May 12, 2015 112 (19) 6206-6211; first published April 27, 2015. https://doi.org/10.1073/pnas.1418852112

• Plant Biology

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    Plastid-produced interorgannellar stress signal MEcPP potentiates induction of the unfolded protein response in endoplasmic reticulum

    Justin Walley, Yanmei Xiao, Jin-Zheng Wang, Edward E. Baidoo, Jay D. Keasling, Zhouxin Shen, Steven P. Briggs, and Katayoon Dehesh

    PNAS May 12, 2015 112 (19) 6212-6217; first published April 28, 2015. https://doi.org/10.1073/pnas.1504828112
  • Open Access

    Syringyl lignin production in conifers: Proof of concept in a Pine tracheary element system

    Armin Wagner, Yuki Tobimatsu, Lorelle Phillips, Heather Flint, Barbara Geddes, Fachuang Lu, and John Ralph

    PNAS May 12, 2015 112 (19) 6218-6223; first published April 20, 2015. https://doi.org/10.1073/pnas.1411926112
  • Open Access

    Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast

    Yang Qu, Michael L. A. E. Easson, Jordan Froese, Razvan Simionescu, Tomas Hudlicky, and Vincenzo De Luca

    PNAS May 12, 2015 112 (19) 6224-6229; first published April 27, 2015. https://doi.org/10.1073/pnas.1501821112
  • Open Access

    Solution structure of the PsIAA4 oligomerization domain reveals interaction modes for transcription factors in early auxin response

    Dhurvas Chandrasekaran Dinesh, Michael Kovermann, Mohanraj Gopalswamy, Antje Hellmuth, Luz Irina A. Calderón Villalobos, Hauke Lilie, Jochen Balbach, and Steffen Abel

    PNAS May 12, 2015 112 (19) 6230-6235; first published April 27, 2015. https://doi.org/10.1073/pnas.1424077112

• Sustainability Science

  • Open Access

    Operationalizing the social-ecological systems framework to assess sustainability

    Heather M. Leslie, Xavier Basurto, Mateja Nenadovic, Leila Sievanen, Kyle C. Cavanaugh, Juan José Cota-Nieto, Brad E. Erisman, Elena Finkbeiner, Gustavo Hinojosa-Arango, Marcia Moreno-Báez, Sriniketh Nagavarapu, Sheila M. W. Reddy, Alexandra Sánchez-Rodríguez, Katherine Siegel, José Juan Ulibarria-Valenzuela, Amy Hudson Weaver, and Octavio Aburto-Oropeza

    PNAS May 12, 2015 112 (19) 5979-5984; first published April 27, 2015. https://doi.org/10.1073/pnas.1414640112
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    Enhancing ecosystem restoration efficiency through spatial and temporal coordination

    Thomas M. Neeson, Michael C. Ferris, Matthew W. Diebel, Patrick J. Doran, Jesse R. O’Hanley, and Peter B. McIntyre

    PNAS May 12, 2015 112 (19) 6236-6241; first published April 27, 2015. https://doi.org/10.1073/pnas.1423812112