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Research Article

Identifying personal microbiomes using metagenomic codes

Eric A. Franzosa, Katherine Huang, James F. Meadow, Dirk Gevers, Katherine P. Lemon, Brendan J. M. Bohannan, and Curtis Huttenhower
  1. aBiostatistics Department, Harvard School of Public Health, Boston, MA 02115;
  2. bMicrobial Systems and Communities, Genome Sequencing and Analysis Program, The Broad Institute, Cambridge, MA 02142;
  3. cInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403;
  4. dDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142; and
  5. eDivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115

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PNAS June 2, 2015 112 (22) E2930-E2938; first published May 11, 2015; https://doi.org/10.1073/pnas.1423854112
Eric A. Franzosa
aBiostatistics Department, Harvard School of Public Health, Boston, MA 02115;
bMicrobial Systems and Communities, Genome Sequencing and Analysis Program, The Broad Institute, Cambridge, MA 02142;
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Katherine Huang
bMicrobial Systems and Communities, Genome Sequencing and Analysis Program, The Broad Institute, Cambridge, MA 02142;
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James F. Meadow
cInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403;
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Dirk Gevers
bMicrobial Systems and Communities, Genome Sequencing and Analysis Program, The Broad Institute, Cambridge, MA 02142;
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Katherine P. Lemon
dDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142; and
eDivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115
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Brendan J. M. Bohannan
cInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403;
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Curtis Huttenhower
aBiostatistics Department, Harvard School of Public Health, Boston, MA 02115;
bMicrobial Systems and Communities, Genome Sequencing and Analysis Program, The Broad Institute, Cambridge, MA 02142;
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  • For correspondence: chuttenh@hsph.harvard.edu
  1. Edited by Ralph R. Isberg, Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, MA, and approved April 6, 2015 (received for review December 15, 2014)

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Article Information

vol. 112 no. 22 E2930-E2938
DOI: 
https://doi.org/10.1073/pnas.1423854112
PubMed: 
25964341

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue June 2, 2015.
  • Published first May 11, 2015.


Author Information

  1. Eric A. Franzosaa,b,
  2. Katherine Huangb,
  3. James F. Meadowc,
  4. Dirk Geversb,
  5. Katherine P. Lemond,e,
  6. Brendan J. M. Bohannanc, and
  7. Curtis Huttenhowera,b,1
  1. aBiostatistics Department, Harvard School of Public Health, Boston, MA 02115;
  2. bMicrobial Systems and Communities, Genome Sequencing and Analysis Program, The Broad Institute, Cambridge, MA 02142;
  3. cInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403;
  4. dDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142; and
  5. eDivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115
  1. Edited by Ralph R. Isberg, Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, MA, and approved April 6, 2015 (received for review December 15, 2014)

Footnotes

  • ↵1To whom correspondence should be addressed. Email: chuttenh{at}hsph.harvard.edu.
  • Author contributions: E.A.F., D.G., K.P.L., B.J.M.B., and C.H. designed research; E.A.F. and K.H. performed research; E.A.F. and K.H. contributed new reagents/analytic tools; E.A.F., J.F.M., D.G., K.P.L., B.J.M.B., and C.H. analyzed data; and E.A.F., K.H., J.F.M., D.G., K.P.L., B.J.M.B., and C.H. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • See Commentary on page 6778.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1423854112/-/DCSupplemental.

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Article usage

Article usage: May 2015 to March 2021

AbstractFullPdf
May 201510645191418
Jun 20156921319825
Jul 20151460113251
Aug 201579999180
Sep 2015945108172
Oct 2015826135154
Nov 2015765122108
Dec 201580383158
Total 2015231649983266
Jan 2016642214126
Feb 2016532100121
Mar 2016879137144
Apr 201643299119
May 201648294121
Jun 20164658491
Jul 20163374775
Aug 201640060101
Sep 201651566167
Oct 201656782157
Nov 2016605106146
Dec 20164344257
Total 2016629011311425
Jan 20174385782
Feb 20174548369
Mar 20174536596
Apr 201739749126
May 201738983116
Jun 20172813248
Jul 20173413144
Aug 20172795145
Sep 20174396572
Oct 20173165594
Nov 20173596676
Dec 20172646859
Total 20174410705927
Jan 201829910866
Feb 201827815844
Mar 201850937777
Apr 201859849181
May 201834917278
Jun 201831619289
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Human microbiome identifiability
Eric A. Franzosa, Katherine Huang, James F. Meadow, Dirk Gevers, Katherine P. Lemon, Brendan J. M. Bohannan, Curtis Huttenhower
Proceedings of the National Academy of Sciences Jun 2015, 112 (22) E2930-E2938; DOI: 10.1073/pnas.1423854112

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Human microbiome identifiability
Eric A. Franzosa, Katherine Huang, James F. Meadow, Dirk Gevers, Katherine P. Lemon, Brendan J. M. Bohannan, Curtis Huttenhower
Proceedings of the National Academy of Sciences Jun 2015, 112 (22) E2930-E2938; DOI: 10.1073/pnas.1423854112
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  • Biological Sciences
  • Microbiology

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    - May 26, 2015
Proceedings of the National Academy of Sciences: 112 (22)
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