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Research Article

Gain of cis-regulatory activities underlies novel domains of wingless gene expression in Drosophila

Shigeyuki Koshikawa, Matt W. Giorgianni, Kathy Vaccaro, Victoria A. Kassner, John H. Yoder, Thomas Werner, and Sean B. Carroll
PNAS June 16, 2015 112 (24) 7524-7529; first published June 1, 2015; https://doi.org/10.1073/pnas.1509022112
Shigeyuki Koshikawa
aLaboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706;
bHoward Hughes Medical Institute, University of Wisconsin, Madison, WI 53706;
cThe Hakubi Center for Advanced Research and Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan;
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Matt W. Giorgianni
aLaboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706;
bHoward Hughes Medical Institute, University of Wisconsin, Madison, WI 53706;
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Kathy Vaccaro
aLaboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706;
bHoward Hughes Medical Institute, University of Wisconsin, Madison, WI 53706;
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Victoria A. Kassner
aLaboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706;
bHoward Hughes Medical Institute, University of Wisconsin, Madison, WI 53706;
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John H. Yoder
dDepartment of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487;
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Thomas Werner
eDepartment of Biological Sciences, Michigan Technological University, Houghton, MI 49931
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Sean B. Carroll
aLaboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706;
bHoward Hughes Medical Institute, University of Wisconsin, Madison, WI 53706;
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  • For correspondence: carrolls@hhmi.org
  1. Contributed by Sean B. Carroll, May 10, 2015 (sent for review April 2, 2015; reviewed by Michael Eisen and Gregory A. Wray)

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Article Information

vol. 112 no. 24 7524-7529
DOI: 
https://doi.org/10.1073/pnas.1509022112
PubMed: 
26034272

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue June 16, 2015.
  • Published first June 1, 2015.

Copyright & Usage: 
Freely available online through the PNAS open access option.

Author Information

  1. Shigeyuki Koshikawaa,b,c,
  2. Matt W. Giorgiannia,b,
  3. Kathy Vaccaroa,b,
  4. Victoria A. Kassnera,b,
  5. John H. Yoderd,
  6. Thomas Wernere, and
  7. Sean B. Carrolla,b,1
  1. aLaboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706;
  2. bHoward Hughes Medical Institute, University of Wisconsin, Madison, WI 53706;
  3. cThe Hakubi Center for Advanced Research and Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan;
  4. dDepartment of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487;
  5. eDepartment of Biological Sciences, Michigan Technological University, Houghton, MI 49931
  1. Contributed by Sean B. Carroll, May 10, 2015 (sent for review April 2, 2015; reviewed by Michael Eisen and Gregory A. Wray)

Footnotes

  • ↵1To whom correspondence should be addressed. Email: carrolls{at}hhmi.org.
  • Author contributions: S.K. and S.B.C. designed research; S.K., M.W.G., K.V., V.A.K., J.H.Y., and T.W. performed research; S.K., K.V., V.A.K., and J.H.Y. contributed new reagents/analytic tools; S.K., M.W.G., and S.B.C. analyzed data; and S.K., M.W.G., T.W., and S.B.C. wrote the paper.

  • Reviewers: M.E., University of California, Berkeley; and G.A.W., Duke University.

  • The authors declare no conflict of interest.

  • Data deposition: The sequences reported in this paper have been deposited in the GenBank database (accession nos. 1805591 and KP966547).

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1509022112/-/DCSupplemental.

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Article usage

Article usage: May 2015 to January 2021

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May 2015803
Jun 201557862321097
Jul 2015777116166
Aug 20153007867
Sep 20151935286
Oct 20151543883
Nov 20151433763
Dec 2015772131
Total 201574385741596
Jan 20161042447
Feb 2016873351
Mar 20161393539
Apr 20161033927
May 2016974033
Jun 2016633836
Jul 2016752126
Aug 2016603214
Sep 2016622726
Oct 2016623319
Nov 2016983631
Dec 2016883128
Total 20161038389377
Jan 2017712423
Feb 2017732117
Mar 2017742833
Apr 2017562916
May 2017901919
Jun 2017461520
Jul 2017522320
Aug 2017462119
Sep 2017601915
Oct 2017633518
Nov 20171182328
Dec 20171202122
Total 2017869278250
Jan 20181023712
Feb 2018443318
Mar 2018503919
Apr 2018564221
May 2018645415
Jun 2018644811
Jul 2018403011
Aug 201853308
Sep 2018634717
Oct 2018205113
Nov 2018176622
Dec 2018183918
Total 2018591516185
Jan 2019243425
Feb 2019153611
Mar 2019174220
Apr 2019145721
May 2019117230
Jun 2019103114
Jul 2019102818
Aug 201994218
Sep 2019710216
Oct 2019267528
Nov 2019113612
Dec 201910379
Total 2019164592222
Jan 2020175612
Feb 202043113
Mar 2020194311
Apr 2020164772
May 2020147913
Jun 20202267
Jul 20202257
Aug 202061612
Sep 202053412
Oct 2020164725
Nov 2020225228
Dec 2020163821
Total 2020139494233
Jan 20218239
Total 20218239
Total1024728662872
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Novel Drosophila wingless enhancers
Shigeyuki Koshikawa, Matt W. Giorgianni, Kathy Vaccaro, Victoria A. Kassner, John H. Yoder, Thomas Werner, Sean B. Carroll
Proceedings of the National Academy of Sciences Jun 2015, 112 (24) 7524-7529; DOI: 10.1073/pnas.1509022112

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Novel Drosophila wingless enhancers
Shigeyuki Koshikawa, Matt W. Giorgianni, Kathy Vaccaro, Victoria A. Kassner, John H. Yoder, Thomas Werner, Sean B. Carroll
Proceedings of the National Academy of Sciences Jun 2015, 112 (24) 7524-7529; DOI: 10.1073/pnas.1509022112
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