New Research In
Physical Sciences
Social Sciences
Featured Portals
Articles by Topic
Biological Sciences
Featured Portals
Articles by Topic
- Agricultural Sciences
- Anthropology
- Applied Biological Sciences
- Biochemistry
- Biophysics and Computational Biology
- Cell Biology
- Developmental Biology
- Ecology
- Environmental Sciences
- Evolution
- Genetics
- Immunology and Inflammation
- Medical Sciences
- Microbiology
- Neuroscience
- Pharmacology
- Physiology
- Plant Biology
- Population Biology
- Psychological and Cognitive Sciences
- Sustainability Science
- Systems Biology
Impact synthesis of the RNA bases

Any discussion related to how life began on this planet inevitably invokes the question as to the origin of bio-organic molecules, a field called prebiotic chemistry (1). How did organic compounds come to populate the early Earth? Before 1953, this question itself was not widely considered within the realm of experimental science. However, since the pioneering results of the Miller–Urey experiment that produced amino acids from electrical discharges passing through simple gases (2), the field of prebiotic chemistry has been extremely prodigious in demonstrating abiotic syntheses for multitudes of organic compounds. However, it became apparent that prebiotic chemistry was faced with a more challenging question. How did the biomolecules of life get selected out of such complex, prebiotic mixtures?
Particular significance has been placed on understanding the selection of the nucleobases adenine (A), cytosine (C), guanine (G), and uracil (U), given their role in the RNA world hypothesis (3). The hypothesis is a premise that life may have emerged with genetic and enzymatic function based exclusively on RNA (4). Some research has pointed to the possibility that selection criteria may have relied on nucleobases that were able to persist the longest in the prebiotic environment. Others have considered the possibility that early RNA life used a wide range of nucleobases, and over time unique selection pressures emerged that favored the extant bases. In terms of using a synthetic origin or availability argument, it has been found that varying conditions are needed to demonstrate the production of all of the RNA bases. Invoking multiple stage and multiple environmental scenarios for the selective prebiotic …
↵1Email: andro.c.rios{at}nasa.gov.
Citation Manager Formats
Sign up for Article Alerts
Article Classifications
- Physical Sciences
- Chemistry
See related content: