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August 25, 2015; vol. 112 no. 34

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Cover image: Pictured is the millipede Chamberlinius hualienensis, an invasive species in southern Japan that secretes hydrogen cyanide as a defensive mechanism. Mohammad Dadashipour et al. isolated a hydroxynitrile lyase (HNL) enzyme, which catalyzes the synthesis of various building blocks of fine chemicals and pharmaceuticals, from this millipede. The C. hualienensis enzyme displayed the highest specific activity of any known HNL, a unique structure, and stability over a wide range of temperatures and pH, rendering the enzyme potentially suitable for industrial use. The findings suggest that millipedes and other arthropods might be a valuable source of industrial biocatalysts. See the article by Dadashipour et al. on pages 10605–10610. Image courtesy of Yuko Ishida.

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