Table of Contents

Biological Sciences

• Agricultural Sciences

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    A parthenogenesis gene of apomict origin elicits embryo formation from unfertilized eggs in a sexual plant

    Joann A. Conner, Muruganantham Mookkan, Heqiang Huo, Keun Chae, and Peggy Ozias-Akins

    PNAS September 8, 2015 112 (36) 11205-11210; first published August 24, 2015. https://doi.org/10.1073/pnas.1505856112
  • Open Access

    Point mutation impairs centromeric CENH3 loading and induces haploid plants

    Raheleh Karimi-Ashtiyani, Takayoshi Ishii, Markus Niessen, Nils Stein, Stefan Heckmann, Maia Gurushidze, Ali Mohammad Banaei-Moghaddam, Jörg Fuchs, Veit Schubert, Kerstin Koch, Oda Weiss, Dmitri Demidov, Klaus Schmidt, Jochen Kumlehn, and Andreas Houben

    PNAS September 8, 2015 112 (36) 11211-11216; first published August 20, 2015. https://doi.org/10.1073/pnas.1504333112

• Anthropology

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    The massacre mass grave of Schöneck-Kilianstädten reveals new insights into collective violence in Early Neolithic Central Europe

    Christian Meyer, Christian Lohr, Detlef Gronenborn, and Kurt W. Alt

    PNAS September 8, 2015 112 (36) 11217-11222; first published August 17, 2015. https://doi.org/10.1073/pnas.1504365112

• Biochemistry

  • Open Access

    Allosteric activation of apicomplexan calcium-dependent protein kinases

    Jessica R. Ingram, Kevin E. Knockenhauer, Benedikt M. Markus, Joseph Mandelbaum, Alexander Ramek, Yibing Shan, David E. Shaw, Thomas U. Schwartz, Hidde L. Ploegh, and Sebastian Lourido

    PNAS September 8, 2015 112 (36) E4975-E4984; first published August 24, 2015. https://doi.org/10.1073/pnas.1505914112
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    Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase

    Irina Bruck and Daniel L. Kaplan

    PNAS September 8, 2015 112 (36) 11223-11228; first published August 24, 2015. https://doi.org/10.1073/pnas.1509608112
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    Structural basis of antizyme-mediated regulation of polyamine homeostasis

    Hsiang-Yi Wu, Shin-Fu Chen, Ju-Yi Hsieh, Fang Chou, Yu-Hsuan Wang, Wan-Ting Lin, Pei-Ying Lee, Yu-Jen Yu, Li-Ying Lin, Te-Sheng Lin, Chieh-Liang Lin, Guang-Yaw Liu, Shiou-Ru Tzeng, Hui-Chih Hung, and Nei-Li Chan

    PNAS September 8, 2015 112 (36) 11229-11234; first published August 24, 2015. https://doi.org/10.1073/pnas.1508187112
  • Open Access

    Velocities of unloaded muscle filaments are not limited by drag forces imposed by myosin cross-bridges

    Richard K. Brizendine, Diego B. Alcala, Michael S. Carter, Brian D. Haldeman, Kevin C. Facemyer, Josh E. Baker, and Christine R. Cremo

    PNAS September 8, 2015 112 (36) 11235-11240; first published August 20, 2015. https://doi.org/10.1073/pnas.1510241112

• Biophysics and Computational Biology

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    Protein folding guides disulfide bond formation

    Meng Qin, Wei Wang, and D. Thirumalai

    PNAS September 8, 2015 112 (36) 11241-11246; first published August 21, 2015. https://doi.org/10.1073/pnas.1503909112
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    Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase

    Javier Suarez and Vern L. Schramm

    PNAS September 8, 2015 112 (36) 11247-11251; first published August 24, 2015. https://doi.org/10.1073/pnas.1513956112
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    Structure of an intermediate conformer of the spindle checkpoint protein Mad2

    Mayuko Hara, Engin Özkan, Hongbin Sun, Hongtao Yu, and Xuelian Luo

    PNAS September 8, 2015 112 (36) 11252-11257; first published August 24, 2015. https://doi.org/10.1073/pnas.1512197112
  • Open Access

    Mechanical control of mitotic progression in single animal cells

    Cedric J. Cattin, Marcel Düggelin, David Martinez-Martin, Christoph Gerber, Daniel J. Müller, and Martin P. Stewart

    PNAS September 8, 2015 112 (36) 11258-11263; first published August 25, 2015. https://doi.org/10.1073/pnas.1502029112

• Cell Biology

  • Open Access

    In situ structural analysis of Golgi intracisternal protein arrays

    Benjamin D. Engel, Miroslava Schaffer, Sahradha Albert, Shoh Asano, Jürgen M. Plitzko, and Wolfgang Baumeister

    PNAS September 8, 2015 112 (36) 11264-11269; first published August 26, 2015. https://doi.org/10.1073/pnas.1515337112
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    Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells

    Sadia Rahman, Mathew J. K. Jones, and Prasad V. Jallepalli

    PNAS September 8, 2015 112 (36) 11270-11275; first published August 24, 2015. https://doi.org/10.1073/pnas.1505323112
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    Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction

    Miguel Mano, Rudy Ippodrino, Lorena Zentilin, Serena Zacchigna, and Mauro Giacca

    PNAS September 8, 2015 112 (36) 11276-11281; first published August 24, 2015. https://doi.org/10.1073/pnas.1503607112
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    Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

    Salim Khiati, Simone A. Baechler, Valentina M. Factor, Hongliang Zhang, Shar-yin N. Huang, Ilaria Dalla Rosa, Carole Sourbier, Leonard Neckers, Snorri S. Thorgeirsson, and Yves Pommier

    PNAS September 8, 2015 112 (36) 11282-11287; first published August 24, 2015. https://doi.org/10.1073/pnas.1511016112
  • Open Access

    Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

    Christian Kukat, Karen M. Davies, Christian A. Wurm, Henrik Spåhr, Nina A. Bonekamp, Inge Kühl, Friederike Joos, Paola Loguercio Polosa, Chan Bae Park, Viktor Posse, Maria Falkenberg, Stefan Jakobs, Werner Kühlbrandt, and Nils-Göran Larsson

    PNAS September 8, 2015 112 (36) 11288-11293; first published August 24, 2015. https://doi.org/10.1073/pnas.1512131112

• Developmental Biology

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    The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain

    Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlén, and Kazunori Nakajima

    PNAS September 8, 2015 112 (36) E4985-E4994; first published August 24, 2015. https://doi.org/10.1073/pnas.1420701112
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    Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis

    Feifei Wang, Joseph J. Tidei, Eric D. Polich, Yu Gao, Huashan Zhao, Nora I. Perrone-Bizzozero, Weixiang Guo, and Xinyu Zhao

    PNAS September 8, 2015 112 (36) E4995-E5004; first published August 24, 2015. https://doi.org/10.1073/pnas.1513780112

• Ecology

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    Chemical fingerprints encode mother–offspring similarity, colony membership, relatedness, and genetic quality in fur seals

    • From the Cover

    Martin A. Stoffel, Barbara A. Caspers, Jaume Forcada, Athina Giannakara, Markus Baier, Luke Eberhart-Phillips, Caroline Müller, and Joseph I. Hoffman

    PNAS September 8, 2015 112 (36) E5005-E5012; first published August 10, 2015. https://doi.org/10.1073/pnas.1506076112

    See companion article:

    • Chemical fingerprints in wild mammals

      - Aug 26, 2015
  • Open Access

    Native root-associated bacteria rescue a plant from a sudden-wilt disease that emerged during continuous cropping

    Rakesh Santhanam, Van Thi Luu, Arne Weinhold, Jay Goldberg, Youngjoo Oh, and Ian T. Baldwin

    PNAS September 8, 2015 112 (36) E5013-E5020; first published August 25, 2015. https://doi.org/10.1073/pnas.1505765112
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    Local host specialization, host-switching, and dispersal shape the regional distributions of avian haemosporidian parasites

    Vincenzo A. Ellis, Michael D. Collins, Matthew C. I. Medeiros, Eloisa H. R. Sari, Elyse D. Coffey, Rebecca C. Dickerson, Camile Lugarini, Jeffrey A. Stratford, Donata R. Henry, Loren Merrill, Alix E. Matthews, Alison A. Hanson, Jackson R. Roberts, Michael Joyce, Melanie R. Kunkel, and Robert E. Ricklefs

    PNAS September 8, 2015 112 (36) 11294-11299; first published August 24, 2015. https://doi.org/10.1073/pnas.1515309112
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    Endosymbionts escape dead hydrothermal vent tubeworms to enrich the free-living population

    Julia Klose, Martin F. Polz, Michael Wagner, Mario P. Schimak, Sabine Gollner, and Monika Bright

    PNAS September 8, 2015 112 (36) 11300-11305; first published August 17, 2015. https://doi.org/10.1073/pnas.1501160112

• Evolution

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    Fate of a mutation in a fluctuating environment

    Ivana Cvijović, Benjamin H. Good, Elizabeth R. Jerison, and Michael M. Desai

    PNAS September 8, 2015 112 (36) E5021-E5028; first published August 24, 2015. https://doi.org/10.1073/pnas.1505406112
  • Open Access

    Burkholderia bacteria infectiously induce the proto-farming symbiosis of Dictyostelium amoebae and food bacteria

    Susanne DiSalvo, Tamara S. Haselkorn, Usman Bashir, Daniela Jimenez, Debra A. Brock, David C. Queller, and Joan E. Strassmann

    PNAS September 8, 2015 112 (36) E5029-E5037; first published August 24, 2015. https://doi.org/10.1073/pnas.1511878112
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    Crowded growth leads to the spontaneous evolution of semistable coexistence in laboratory yeast populations

    • From the Cover

    Evgeni M. Frenkel, Michael J. McDonald, J. David Van Dyken, Katya Kosheleva, Gregory I. Lang, and Michael M. Desai

    PNAS September 8, 2015 112 (36) 11306-11311; first published August 3, 2015. https://doi.org/10.1073/pnas.1506184112

    See companion article:

    • Coexistence by crowding avoidance

      - Aug 26, 2015

• Genetics

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    Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding

    Christopher J. Webb and Virginia A. Zakian

    PNAS September 8, 2015 112 (36) 11312-11317; first published August 24, 2015. https://doi.org/10.1073/pnas.1503157112

• Immunology and Inflammation

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    IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation

    Rebecca A. Sosa, Cathi Murphey, Rachel R. Robinson, and Thomas G. Forsthuber

    PNAS September 8, 2015 112 (36) E5038-E5047; first published August 24, 2015. https://doi.org/10.1073/pnas.1505955112
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    NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets

    Changyun Hu, Heyuan Ding, Yangyang Li, James A. Pearson, Xiaojun Zhang, Richard A. Flavell, F. Susan Wong, and Li Wen

    PNAS September 8, 2015 112 (36) 11318-11323; first published August 24, 2015. https://doi.org/10.1073/pnas.1513509112
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    Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6

    Dandan Lin, Man Zhang, Meng-Xin Zhang, Yujie Ren, Jie Jin, Quanyi Zhao, Zishu Pan, Min Wu, Hong-Bing Shu, Chen Dong, and Bo Zhong

    PNAS September 8, 2015 112 (36) 11324-11329; first published August 24, 2015. https://doi.org/10.1073/pnas.1509968112

• Medical Sciences

  • Open Access

    Effect of aging on muscle mitochondrial substrate utilization in humans

    Kitt Falk Petersen, Katsutaro Morino, Tiago C. Alves, Richard G. Kibbey, Sylvie Dufour, Saki Sono, Peter S. Yoo, Gary W. Cline, and Gerald I. Shulman

    PNAS September 8, 2015 112 (36) 11330-11334; first published August 24, 2015. https://doi.org/10.1073/pnas.1514844112
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    Increasing disparities between resource inputs and outcomes, as measured by certain health deliverables, in biomedical research

    • From the Cover

    Anthony Bowen and Arturo Casadevall

    PNAS September 8, 2015 112 (36) 11335-11340; first published August 17, 2015. https://doi.org/10.1073/pnas.1504955112

    See companion article:

    • More study needed on biomedical research phases

      - Nov 10, 2015

• Microbiology

  • Open Access

    Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover

    Mona W. Orr, Gregory P. Donaldson, Geoffrey B. Severin, Jingxin Wang, Herman O. Sintim, Christopher M. Waters, and Vincent T. Lee

    PNAS September 8, 2015 112 (36) E5048-E5057; first published August 24, 2015. https://doi.org/10.1073/pnas.1507245112

    See companion article:

    • Oligoribonuclease functions in c-di-GMP signaling

      - Aug 24, 2015
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    Contact-dependent growth inhibition toxins exploit multiple independent cell-entry pathways

    Julia L. E. Willett, Grant C. Gucinski, Jackson P. Fatherree, David A. Low, and Christopher S. Hayes

    PNAS September 8, 2015 112 (36) 11341-11346; first published August 24, 2015. https://doi.org/10.1073/pnas.1512124112
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    Bacterial SPOR domains are recruited to septal peptidoglycan by binding to glycan strands that lack stem peptides

    Atsushi Yahashiri, Matthew A. Jorgenson, and David S. Weiss

    PNAS September 8, 2015 112 (36) 11347-11352; first published August 24, 2015. https://doi.org/10.1073/pnas.1508536112
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    Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix

    Laura K. Jennings, Kelly M. Storek, Hannah E. Ledvina, Charlène Coulon, Lindsey S. Marmont, Irina Sadovskaya, Patrick R. Secor, Boo Shan Tseng, Michele Scian, Alain Filloux, Daniel J. Wozniak, P. Lynne Howell, and Matthew R. Parsek

    PNAS September 8, 2015 112 (36) 11353-11358; first published August 26, 2015. https://doi.org/10.1073/pnas.1503058112
  • Open Access

    Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa

    Dorit Cohen, Undine Mechold, Hadas Nevenzal, Yafit Yarmiyhu, Trevor E. Randall, Denice C. Bay, Jacquelyn D. Rich, Matthew R. Parsek, Volkhard Kaever, Joe J. Harrison, and Ehud Banin

    PNAS September 8, 2015 112 (36) 11359-11364; first published August 24, 2015. https://doi.org/10.1073/pnas.1421450112

    See companion article:

    • Oligoribonuclease degrades pGpG

      - Aug 24, 2015
  • Open Access

    Fungal biosynthesis of the bibenzoquinone oosporein to evade insect immunity

    Peng Feng, Yanfang Shang, Kai Cen, and Chengshu Wang

    PNAS September 8, 2015 112 (36) 11365-11370; first published August 24, 2015. https://doi.org/10.1073/pnas.1503200112
  • Open Access

    Expanded metabolic versatility of ubiquitous nitrite-oxidizing bacteria from the genus Nitrospira

    Hanna Koch, Sebastian Lücker, Mads Albertsen, Katharina Kitzinger, Craig Herbold, Eva Spieck, Per Halkjaer Nielsen, Michael Wagner, and Holger Daims

    PNAS September 8, 2015 112 (36) 11371-11376; first published August 24, 2015. https://doi.org/10.1073/pnas.1506533112

• Neuroscience

  • Open Access

    Subset of early radial glial progenitors that contribute to the development of callosal neurons is absent from avian brain

    Fernando García-Moreno and Zoltán Molnár

    PNAS September 8, 2015 112 (36) E5058-E5067; first published August 25, 2015. https://doi.org/10.1073/pnas.1506377112
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    Transcription factor p63 controls the reserve status but not the stemness of horizontal basal cells in the olfactory epithelium

    Nikolai Schnittke, Daniel B. Herrick, Brian Lin, Jesse Peterson, Julie H. Coleman, Adam I. Packard, Woochan Jang, and James E. Schwob

    PNAS September 8, 2015 112 (36) E5068-E5077; first published August 25, 2015. https://doi.org/10.1073/pnas.1512272112
  • Open Access

    Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

    G. Aleph Prieto, Shikha Snigdha, David Baglietto-Vargas, Erica D. Smith, Nicole C. Berchtold, Liqi Tong, Dariush Ajami, Frank M. LaFerla, Julius Rebek Jr., and Carl W. Cotman

    PNAS September 8, 2015 112 (36) E5078-E5087; first published August 24, 2015. https://doi.org/10.1073/pnas.1514486112
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    Deep two-photon brain imaging with a red-shifted fluorometric Ca²⁺ indicator

    Carsten Tischbirek, Antje Birkner, Hongbo Jia, Bert Sakmann, and Arthur Konnerth

    PNAS September 8, 2015 112 (36) 11377-11382; first published August 24, 2015. https://doi.org/10.1073/pnas.1514209112
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    Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning

    Takashi Yamaguchi, Akihiro Goto, Ichiro Nakahara, Satoshi Yawata, Takatoshi Hikida, Michiyuki Matsuda, Kazuo Funabiki, and Shigetada Nakanishi

    PNAS September 8, 2015 112 (36) 11383-11388; first published August 24, 2015. https://doi.org/10.1073/pnas.1514731112

• Pharmacology

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    RGS9-2–controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states

    Vasiliki Mitsi, Dimitra Terzi, Immanuel Purushothaman, Lefteris Manouras, Sevasti Gaspari, Rachael L. Neve, Maria Stratinaki, Jian Feng, Li Shen, and Venetia Zachariou

    PNAS September 8, 2015 112 (36) E5088-E5097; first published August 24, 2015. https://doi.org/10.1073/pnas.1504283112

• Physiology

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    Uterine activin receptor-like kinase 5 is crucial for blastocyst implantation and placental development

    Jia Peng, Diana Monsivais, Ran You, Hua Zhong, Stephanie A. Pangas, and Martin M. Matzuk

    PNAS September 8, 2015 112 (36) E5098-E5107; first published August 24, 2015. https://doi.org/10.1073/pnas.1514498112
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    Mitochondrial calcium overload is a key determinant in heart failure

    • From the Cover

    Gaetano Santulli, Wenjun Xie, Steven R. Reiken, and Andrew R. Marks

    PNAS September 8, 2015 112 (36) 11389-11394; first published July 27, 2015. https://doi.org/10.1073/pnas.1513047112

    See companion article:

    • Mitochondrial calcium in heart failure

      - Aug 26, 2015
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    Neural coding underlying the cue preference for celestial orientation

    Basil el Jundi, Eric J. Warrant, Marcus J. Byrne, Lana Khaldy, Emily Baird, Jochen Smolka, and Marie Dacke

    PNAS September 8, 2015 112 (36) 11395-11400; first published August 24, 2015. https://doi.org/10.1073/pnas.1501272112

• Plant Biology

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    Orchestration of three transporters and distinct vascular structures in node for intervascular transfer of silicon in rice

    Naoki Yamaji, Gen Sakurai, Namiki Mitani-Ueno, and Jian Feng Ma

    PNAS September 8, 2015 112 (36) 11401-11406; first published August 17, 2015. https://doi.org/10.1073/pnas.1508987112
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    Maize death acids, 9-lipoxygenase–derived cyclopente(a)nones, display activity as cytotoxic phytoalexins and transcriptional mediators

    Shawn A. Christensen, Alisa Huffaker, Fatma Kaplan, James Sims, Sebastian Ziemann, Gunther Doehlemann, Lexiang Ji, Robert J. Schmitz, Michael V. Kolomiets, Hans T. Alborn, Naoki Mori, Georg Jander, Xinzhi Ni, Ryan C. Sartor, Sara Byers, Zaid Abdo, and Eric A. Schmelz

    PNAS September 8, 2015 112 (36) 11407-11412; first published August 24, 2015. https://doi.org/10.1073/pnas.1511131112