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Biological Sciences

• Agricultural Sciences

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    Natural variation in ARF18 gene simultaneously affects seed weight and silique length in polyploid rapeseed

    Jing Liu, Wei Hua, Zhiyong Hu, Hongli Yang, Liang Zhang, Rongjun Li, Linbin Deng, Xingchao Sun, Xinfa Wang, and Hanzhong Wang

    PNAS September 15, 2015 112 (37) E5123-E5132; first published August 31, 2015. https://doi.org/10.1073/pnas.1502160112

• Anthropology

  • Open Access

    Postcranial morphology of the middle Pleistocene humans from Sima de los Huesos, Spain

    Juan Luis Arsuaga, José-Miguel Carretero, Carlos Lorenzo, Asier Gómez-Olivencia, Adrián Pablos, Laura Rodríguez, Rebeca García-González, Alejandro Bonmatí, Rolf M. Quam, Ana Pantoja-Pérez, Ignacio Martínez, Arantza Aranburu, Ana Gracia-Téllez, Eva Poza-Rey, Nohemi Sala, Nuria García, Almudena Alcázar de Velasco, Gloria Cuenca-Bescós, José María Bermúdez de Castro, and Eudald Carbonell

    PNAS September 15, 2015 112 (37) 11524-11529; first published August 31, 2015. https://doi.org/10.1073/pnas.1514828112

• Applied Biological Sciences

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    Targeted delivery of liquid microvolumes into the lung

    Jinho Kim, John D. O’Neill, N. Valerio Dorrello, Matthew Bacchetta, and Gordana Vunjak-Novakovic

    PNAS September 15, 2015 112 (37) 11530-11535; first published August 31, 2015. https://doi.org/10.1073/pnas.1512613112

• Biochemistry

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    Glassin, a histidine-rich protein from the siliceous skeletal system of the marine sponge Euplectella, directs silica polycondensation

    Katsuhiko Shimizu, Taro Amano, Md. Rezaul Bari, James C. Weaver, Jiro Arima, and Nobuhiro Mori

    PNAS September 15, 2015 112 (37) 11449-11454; first published August 10, 2015. https://doi.org/10.1073/pnas.1506968112
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    Cysteine as a ligand platform in the biosynthesis of the FeFe hydrogenase H cluster

    Daniel L. M. Suess, Ingmar Bürstel, Liliana De La Paz, Jon M. Kuchenreuther, Cindy C. Pham, Stephen P. Cramer, James R. Swartz, and R. David Britt

    PNAS September 15, 2015 112 (37) 11455-11460; first published August 31, 2015. https://doi.org/10.1073/pnas.1508440112
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    Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes

    Shirly Miniowitz-Shemtov, Ety Eytan, Sharon Kaisari, Danielle Sitry-Shevah, and Avram Hershko

    PNAS September 15, 2015 112 (37) 11536-11540; first published August 31, 2015. https://doi.org/10.1073/pnas.1515358112
  • Open Access

    Structure of Drosophila Oskar reveals a novel RNA binding protein

    Na Yang, Zhenyu Yu, Menglong Hu, Mingzhu Wang, Ruth Lehmann, and Rui-Ming Xu

    PNAS September 15, 2015 112 (37) 11541-11546; first published August 31, 2015. https://doi.org/10.1073/pnas.1515568112
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    Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily

    • From the Cover

    Kathryn M. McCulloch, Emilianne K. McCranie, Jarrod A. Smith, Maruf Sarwar, Jeannette L. Mathieu, Bryan L. Gitschlag, Yu Du, Brian O. Bachmann, and T. M. Iverson

    PNAS September 15, 2015 112 (37) 11547-11552; first published August 3, 2015. https://doi.org/10.1073/pnas.1500964112

    See companion article:

    • Unusual oxacycles in the orthosomycin antibiotics

      - Sep 16, 2015
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    Dual allosteric activation mechanisms in monomeric human glucokinase

    • From the Cover

    A. Carl Whittington, Mioara Larion, Joseph M. Bowler, Kristen M. Ramsey, Rafael Brüschweiler, and Brian G. Miller

    PNAS September 15, 2015 112 (37) 11553-11558; first published August 17, 2015. https://doi.org/10.1073/pnas.1506664112

    See companion article:

    • Allostery vs. “allokairy”

      - Sep 08, 2015
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    Roles of helix H69 of 23S rRNA in translation initiation

    Qi Liu and Kurt Fredrick

    PNAS September 15, 2015 112 (37) 11559-11564; first published August 31, 2015. https://doi.org/10.1073/pnas.1507703112

• Biophysics and Computational Biology

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    Micromechanics of cellularized biopolymer networks

    Christopher A. R. Jones, Matthew Cibula, Jingchen Feng, Emma A. Krnacik, David H. McIntyre, Herbert Levine, and Bo Sun

    PNAS September 15, 2015 112 (37) E5117-E5122; first published August 31, 2015. https://doi.org/10.1073/pnas.1509663112
  • Open Access

    Assembly, translocation, and activation of XerCD-dif recombination by FtsK translocase analyzed in real-time by FRET and two-color tethered fluorophore motion

    Peter F. J. May, Pawel Zawadzki, David J. Sherratt, Achillefs N. Kapanidis, and Lidia K. Arciszewska

    PNAS September 15, 2015 112 (37) E5133-E5141; first published August 31, 2015. https://doi.org/10.1073/pnas.1510814112
  • Open Access

    Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble

    Levani Zandarashvili, Alexandre Esadze, Dana Vuzman, Catherine A. Kemme, Yaakov Levy, and Junji Iwahara

    PNAS September 15, 2015 112 (37) E5142-E5149; first published August 31, 2015. https://doi.org/10.1073/pnas.1507726112
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    Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering

    Vincenzo Venditti, Charles D. Schwieters, Alexander Grishaev, and G. Marius Clore

    PNAS September 15, 2015 112 (37) 11565-11570; first published August 24, 2015. https://doi.org/10.1073/pnas.1515366112
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    Redox-induced activation of the proton pump in the respiratory complex I

    Vivek Sharma, Galina Belevich, Ana P. Gamiz-Hernandez, Tomasz Róg, Ilpo Vattulainen, Marina L. Verkhovskaya, Mårten Wikström, Gerhard Hummer, and Ville R. I. Kaila

    PNAS September 15, 2015 112 (37) 11571-11576; first published September 1, 2015. https://doi.org/10.1073/pnas.1503761112

• Cell Biology

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    Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels

    Violaine Delorme-Walker, Ji-Yeon Seo, Antje Gohla, Bruce Fowler, Ben Bohl, and Céline DerMardirossian

    PNAS September 15, 2015 112 (37) E5150-E5159; first published August 31, 2015. https://doi.org/10.1073/pnas.1510945112
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    Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression

    Justine S. Paradis, Stevenson Ly, Élodie Blondel-Tepaz, Jacob A. Galan, Alexandre Beautrait, Mark G. H. Scott, Hervé Enslen, Stefano Marullo, Philippe P. Roux, and Michel Bouvier

    PNAS September 15, 2015 112 (37) E5160-E5168; first published August 31, 2015. https://doi.org/10.1073/pnas.1508836112
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    p63 supports aerobic respiration through hexokinase II

    Guiditta Viticchiè, Massimiliano Agostini, Anna Maria Lena, Mara Mancini, Huiqing Zhou, Lello Zolla, David Dinsdale, Gaelle Saintigny, Gerry Melino, and Eleonora Candi

    PNAS September 15, 2015 112 (37) 11577-11582; first published August 31, 2015. https://doi.org/10.1073/pnas.1508871112
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    NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

    Sarah Croessmann, Hong Yuen Wong, Daniel J. Zabransky, David Chu, Janet Mendonca, Anup Sharma, Morassa Mohseni, D. Marc Rosen, Robert B. Scharpf, Justin Cidado, Rory L. Cochran, Heather A. Parsons, W. Brian Dalton, Bracha Erlanger, Berry Button, Karen Cravero, Kelly Kyker-Snowman, Julia A. Beaver, Sushant Kachhap, Paula J. Hurley, Josh Lauring, and Ben Ho Park

    PNAS September 15, 2015 112 (37) 11583-11588; first published August 31, 2015. https://doi.org/10.1073/pnas.1503683112

• Developmental Biology

  • Open Access

    Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system

    Ieva Gailite, Birgit L. Aerne, and Nicolas Tapon

    PNAS September 15, 2015 112 (37) E5169-E5178; first published August 31, 2015. https://doi.org/10.1073/pnas.1505512112

• Ecology

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    Dietary changes of large herbivores in the Turkana Basin, Kenya from 4 to 1 Ma

    • From the Cover

    Thure E. Cerling, Samuel A. Andanje, Scott A. Blumenthal, Francis H. Brown, Kendra L. Chritz, John M. Harris, John A. Hart, Francis M. Kirera, Prince Kaleme, Louise N. Leakey, Meave G. Leakey, Naomi E. Levin, Fredrick Kyalo Manthi, Benjamin H. Passey, and Kevin T. Uno

    PNAS September 15, 2015 112 (37) 11467-11472; first published August 3, 2015. https://doi.org/10.1073/pnas.1513075112

    See companion article:

    • Four million years of African herbivory

      - Aug 31, 2015
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    Termite mounds harness diurnal temperature oscillations for ventilation

    Hunter King, Samuel Ocko, and L. Mahadevan

    PNAS September 15, 2015 112 (37) 11589-11593; first published August 27, 2015. https://doi.org/10.1073/pnas.1423242112
  • Open Access

    Dynamics of an experimental microbial invasion

    Francisco Acosta, Richard M. Zamor, Fares Z. Najar, Bruce A. Roe, and K. David Hambright

    PNAS September 15, 2015 112 (37) 11594-11599; first published August 31, 2015. https://doi.org/10.1073/pnas.1505204112

• Environmental Sciences

  • Open Access

    Fog and rain in the Amazon

    Usama Anber, Pierre Gentine, Shuguang Wang, and Adam H. Sobel

    PNAS September 15, 2015 112 (37) 11473-11477; first published August 31, 2015. https://doi.org/10.1073/pnas.1505077112

• Evolution

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    Insect’s intestinal organ for symbiont sorting

    Tsubasa Ohbayashi, Kazutaka Takeshita, Wataru Kitagawa, Naruo Nikoh, Ryuichi Koga, Xian-Ying Meng, Kanako Tago, Tomoyuki Hori, Masahito Hayatsu, Kozo Asano, Yoichi Kamagata, Bok Luel Lee, Takema Fukatsu, and Yoshitomo Kikuchi

    PNAS September 15, 2015 112 (37) E5179-E5188; first published August 31, 2015. https://doi.org/10.1073/pnas.1511454112
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    The adaptive radiation of lichen-forming Teloschistaceae is associated with sunscreening pigments and a bark-to-rock substrate shift

    Ester Gaya, Samantha Fernández-Brime, Reinaldo Vargas, Robert F. Lachlan, Cécile Gueidan, Martín Ramírez-Mejía, and François Lutzoni

    PNAS September 15, 2015 112 (37) 11600-11605; first published August 31, 2015. https://doi.org/10.1073/pnas.1507072112

• Genetics

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    spenito is required for sex determination in Drosophila melanogaster

    Dong Yan and Norbert Perrimon

    PNAS September 15, 2015 112 (37) 11606-11611; first published August 31, 2015. https://doi.org/10.1073/pnas.1515891112

• Immunology and Inflammation

  • Open Access

    Comparison of predicted and actual consequences of missense mutations

    Lisa A. Miosge, Matthew A. Field, Yovina Sontani, Vicky Cho, Simon Johnson, Anna Palkova, Bhavani Balakishnan, Rong Liang, Yafei Zhang, Stephen Lyon, Bruce Beutler, Belinda Whittle, Edward M. Bertram, Anselm Enders, Christopher C. Goodnow, and T. Daniel Andrews

    PNAS September 15, 2015 112 (37) E5189-E5198; first published August 12, 2015. https://doi.org/10.1073/pnas.1511585112

    See companion article:

    • Predicting impact of genetic variation in silico

      - Sep 08, 2015
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    Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2A

    Takeharu Minamitani, Teruhito Yasui, Yijie Ma, Hufeng Zhou, Daisuke Okuzaki, Chiau-Yuang Tsai, Shuhei Sakakibara, Benjamin E. Gewurz, Elliott Kieff, and Hitoshi Kikutani

    PNAS September 15, 2015 112 (37) 11612-11617; first published August 24, 2015. https://doi.org/10.1073/pnas.1514484112
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    C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis

    Munitta Muthana, Sarah Hawtree, Adam Wilshaw, Eimear Linehan, Hannah Roberts, Sachin Khetan, Gbadebo Adeleke, Fiona Wright, Mohammed Akil, Ursula Fearon, Douglas Veale, Barbara Ciani, and Anthony G. Wilson

    PNAS September 15, 2015 112 (37) 11618-11623; first published August 27, 2015. https://doi.org/10.1073/pnas.1501947112

• Medical Sciences

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    Epigenetic silencing of tumor suppressor genes during in vitro Epstein–Barr virus infection

    Abhik Saha, Hem C. Jha, Santosh K. Upadhyay, and Erle S. Robertson

    PNAS September 15, 2015 112 (37) E5199-E5207; first published August 31, 2015. https://doi.org/10.1073/pnas.1503806112
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    Label-free DNA imaging in vivo with stimulated Raman scattering microscopy

    Fa-Ke Lu, Srinjan Basu, Vivien Igras, Mai P. Hoang, Minbiao Ji, Dan Fu, Gary R. Holtom, Victor A. Neel, Christian W. Freudiger, David E. Fisher, and X. Sunney Xie

    PNAS September 15, 2015 112 (37) 11624-11629; first published August 31, 2015. https://doi.org/10.1073/pnas.1515121112
  • Open Access

    Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

    Yan Wang, Markey C. McNutt, Serena Banfi, Michael G. Levin, William L. Holland, Viktoria Gusarova, Jesper Gromada, Jonathan C. Cohen, and Helen H. Hobbs

    PNAS September 15, 2015 112 (37) 11630-11635; first published August 24, 2015. https://doi.org/10.1073/pnas.1515374112
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    miR-15b/16-2 deletion promotes B-cell malignancies

    Francesca Lovat, Matteo Fassan, Pierluigi Gasparini, Lara Rizzotto, Luciano Cascione, Marco Pizzi, Caterina Vicentini, Veronica Balatti, Dario Palmieri, Stefan Costinean, and Carlo M. Croce

    PNAS September 15, 2015 112 (37) 11636-11641; first published August 31, 2015. https://doi.org/10.1073/pnas.1514954112
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    Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

    Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G. Kaelin Jr., Makoto Suematsu, and Yoji Andrew Minamishima

    PNAS September 15, 2015 112 (37) 11642-11647; first published August 31, 2015. https://doi.org/10.1073/pnas.1515872112
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    Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

    Levy A. Reyes, James Boslett, Saradhadevi Varadharaj, Francesco De Pascali, Craig Hemann, Lawrence J. Druhan, Giuseppe Ambrosio, Mohamed El-Mahdy, and Jay L. Zweier

    PNAS September 15, 2015 112 (37) 11648-11653; first published August 21, 2015. https://doi.org/10.1073/pnas.1505556112
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    Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising

    Shishi Luo and Alan S. Perelson

    PNAS September 15, 2015 112 (37) 11654-11659; first published August 31, 2015. https://doi.org/10.1073/pnas.1505207112

• Microbiology

  • Open Access

    MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth

    Dervla T. Isaac, Rita K. Laguna, Nicole Valtz, and Ralph R. Isberg

    PNAS September 15, 2015 112 (37) E5208-E5217; first published September 1, 2015. https://doi.org/10.1073/pnas.1511389112
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    Structural characterization of muropeptides from Chlamydia trachomatis peptidoglycan by mass spectrometry resolves “chlamydial anomaly”

    Mathanraj Packiam, Brian Weinrick, William R. Jacobs Jr., and Anthony T. Maurelli

    PNAS September 15, 2015 112 (37) 11660-11665; first published August 19, 2015. https://doi.org/10.1073/pnas.1514026112
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    PopZ identifies the new pole, and PodJ identifies the old pole during polar growth in Agrobacterium tumefaciens

    Romain Grangeon, John R. Zupan, James Anderson-Furgeson, and Patricia C. Zambryski

    PNAS September 15, 2015 112 (37) 11666-11671; first published August 31, 2015. https://doi.org/10.1073/pnas.1515544112
  • Open Access

    Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt

    • From the Cover

    Stéphane Pelleau, Eli L. Moss, Satish K. Dhingra, Béatrice Volney, Jessica Casteras, Stanislaw J. Gabryszewski, Sarah K. Volkman, Dyann F. Wirth, Eric Legrand, David A. Fidock, Daniel E. Neafsey, and Lise Musset

    PNAS September 15, 2015 112 (37) 11672-11677; first published August 10, 2015. https://doi.org/10.1073/pnas.1507142112

    See companion article:

    • Compensatory mutation in chloroquine sensitivity

      - Sep 02, 2015

• Neuroscience

  • Open Access

    Thermodynamics and signatures of criticality in a network of neurons

    Gašper Tkačik, Thierry Mora, Olivier Marre, Dario Amodei, Stephanie E. Palmer, Michael J. Berry II, and William Bialek

    PNAS September 15, 2015 112 (37) 11508-11513; first published September 1, 2015. https://doi.org/10.1073/pnas.1514188112
  • Open Access

    Dynamic reconfiguration of frontal brain networks during executive cognition in humans

    Urs Braun, Axel Schäfer, Henrik Walter, Susanne Erk, Nina Romanczuk-Seiferth, Leila Haddad, Janina I. Schweiger, Oliver Grimm, Andreas Heinz, Heike Tost, Andreas Meyer-Lindenberg, and Danielle S. Bassett

    PNAS September 15, 2015 112 (37) 11678-11683; first published August 31, 2015. https://doi.org/10.1073/pnas.1422487112
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    Neural systems supporting linguistic structure, linguistic experience, and symbolic communication in sign language and gesture

    Aaron J. Newman, Ted Supalla, Nina Fernandez, Elissa L. Newport, and Daphne Bavelier

    PNAS September 15, 2015 112 (37) 11684-11689; first published August 17, 2015. https://doi.org/10.1073/pnas.1510527112
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    Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans

    Yushu Chen, Shashank Bharill, Ehud Y. Isacoff, and Martin Chalfie

    PNAS September 15, 2015 112 (37) 11690-11695; first published August 31, 2015. https://doi.org/10.1073/pnas.1515968112
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    Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

    Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A. Andrabi, Valina L. Dawson, Joo-Ho Shin, and Ted M. Dawson

    PNAS September 15, 2015 112 (37) 11696-11701; first published August 31, 2015. https://doi.org/10.1073/pnas.1500624112
  • Open Access

    Mutual regulation between Satb2 and Fezf2 promotes subcerebral projection neuron identity in the developing cerebral cortex

    William L. McKenna, Christian F. Ortiz-Londono, Thomas K. Mathew, Kendy Hoang, Sol Katzman, and Bin Chen

    PNAS September 15, 2015 112 (37) 11702-11707; first published August 31, 2015. https://doi.org/10.1073/pnas.1504144112
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    Evidence integration in model-based tree search

    Alec Solway and Matthew M. Botvinick

    PNAS September 15, 2015 112 (37) 11708-11713; first published August 31, 2015. https://doi.org/10.1073/pnas.1505483112

• Physiology

  • Open Access

    Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis

    Alan C. Chen, Adriana Donovan, Renee Ned-Sykes, and Nancy C. Andrews

    PNAS September 15, 2015 112 (37) 11714-11719; first published August 31, 2015. https://doi.org/10.1073/pnas.1511701112
  • Open Access

    Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities

    Venkateswara R. Chintapalli, Akira Kato, Louise Henderson, Taku Hirata, Debra J. Woods, Gayle Overend, Shireen A. Davies, Michael F. Romero, and Julian A. T. Dow

    PNAS September 15, 2015 112 (37) 11720-11725; first published August 31, 2015. https://doi.org/10.1073/pnas.1508031112

• Plant Biology

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    Discovery of a novel amino acid racemase through exploration of natural variation in Arabidopsis thaliana

    Renee C. Strauch, Elisabeth Svedin, Brian Dilkes, Clint Chapple, and Xu Li

    PNAS September 15, 2015 112 (37) 11726-11731; first published August 31, 2015. https://doi.org/10.1073/pnas.1503272112

• Psychological and Cognitive Sciences

  • Open Access

    An architecture for encoding sentence meaning in left mid-superior temporal cortex

    Steven M. Frankland and Joshua D. Greene

    PNAS September 15, 2015 112 (37) 11732-11737; first published August 24, 2015. https://doi.org/10.1073/pnas.1421236112