Table of Contents

Biological Sciences

• Agricultural Sciences

  • Open Access

    Genome sequencing of adzuki bean (Vigna angularis) provides insight into high starch and low fat accumulation and domestication

    Kai Yang, Zhixi Tian, Chunhai Chen, Longhai Luo, Bo Zhao, Zhuo Wang, Lili Yu, Yisong Li, Yudong Sun, Weiyu Li, Yan Chen, Yongqiang Li, Yueyang Zhang, Danjiao Ai, Jinyang Zhao, Cheng Shang, Yong Ma, Bin Wu, Mingli Wang, Li Gao, Dongjing Sun, Peng Zhang, Fangfang Guo, Weiwei Wang, Yuan Li, Jinlong Wang, Rajeev K. Varshney, Jun Wang, Hong-Qing Ling, and Ping Wan

    PNAS October 27, 2015 112 (43) 13213-13218; first published October 12, 2015. https://doi.org/10.1073/pnas.1420949112

• Applied Biological Sciences

  • Open Access

    pH homeostasis during coral calcification in a free ocean CO₂ enrichment (FOCE) experiment, Heron Island reef flat, Great Barrier Reef

    Lucy Georgiou, James Falter, Julie Trotter, David I. Kline, Michael Holcomb, Sophie G. Dove, Ove Hoegh-Guldberg, and Malcolm McCulloch

    PNAS October 27, 2015 112 (43) 13219-13224; first published October 5, 2015. https://doi.org/10.1073/pnas.1505586112

• Biochemistry

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    Structural analysis of nucleosomal barrier to transcription

    Daria A. Gaykalova, Olga I. Kulaeva, Olesya Volokh, Alexey K. Shaytan, Fu-Kai Hsieh, Mikhail P. Kirpichnikov, Olga S. Sokolova, and Vasily M. Studitsky

    PNAS October 27, 2015 112 (43) E5787-E5795; first published October 12, 2015. https://doi.org/10.1073/pnas.1508371112
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    Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration

    Sangwon Lee, Etienne B. Greenlee, Joseph R. Amick, Gwenda F. Ligon, Jay S. Lillquist, Edward J. Natoli Jr., Yaron Hadari, Diego Alvarado, and Joseph Schlessinger

    PNAS October 27, 2015 112 (43) 13225-13230; first published October 12, 2015. https://doi.org/10.1073/pnas.1518361112
  • Open Access

    Structure of ATP synthase from Paracoccus denitrificans determined by X-ray crystallography at 4.0 Å resolution

    Edgar Morales-Rios, Martin G. Montgomery, Andrew G. W. Leslie, and John E. Walker

    PNAS October 27, 2015 112 (43) 13231-13236; first published October 12, 2015. https://doi.org/10.1073/pnas.1517542112

• Biophysics and Computational Biology

  • Open Access

    Temporal evolution of helix hydration in a light-gated ion channel correlates with ion conductance

    Víctor A. Lórenz-Fonfría, Christian Bamann, Tom Resler, Ramona Schlesinger, Ernst Bamberg, and Joachim Heberle

    PNAS October 27, 2015 112 (43) E5796-E5804; first published October 12, 2015. https://doi.org/10.1073/pnas.1511462112
  • Open Access

    Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus

    Zohar Eyal, Donna Matzov, Miri Krupkin, Itai Wekselman, Susanne Paukner, Ella Zimmerman, Haim Rozenberg, Anat Bashan, and Ada Yonath

    PNAS October 27, 2015 112 (43) E5805-E5814; first published October 13, 2015. https://doi.org/10.1073/pnas.1517952112
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    High-resolution structures of a heterochiral coiled coil

    David E. Mortenson, Jay D. Steinkruger, Dale F. Kreitler, Dominic V. Perroni, Gregory P. Sorenson, Lijun Huang, Ritesh Mittal, Hyun Gi Yun, Benjamin R. Travis, Mahesh K. Mahanthappa, Katrina T. Forest, and Samuel H. Gellman

    PNAS October 27, 2015 112 (43) 13144-13149; first published October 12, 2015. https://doi.org/10.1073/pnas.1507918112
  • Open Access

    Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

    Lorenzo Sborgi, Francesco Ravotti, Venkata P. Dandey, Mathias S. Dick, Adam Mazur, Sina Reckel, Mohamed Chami, Sebastian Scherer, Matthias Huber, Anja Böckmann, Edward H. Egelman, Henning Stahlberg, Petr Broz, Beat H. Meier, and Sebastian Hiller

    PNAS October 27, 2015 112 (43) 13237-13242; first published October 13, 2015. https://doi.org/10.1073/pnas.1507579112

• Developmental Biology

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    Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans

    Chaogu Zheng, Margarete Diaz-Cuadros, and Martin Chalfie

    PNAS October 27, 2015 112 (43) 13243-13248; first published October 12, 2015. https://doi.org/10.1073/pnas.1518686112
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    Lgr6 marks nail stem cells and is required for digit tip regeneration

    Jessica A. Lehoczky and Clifford J. Tabin

    PNAS October 27, 2015 112 (43) 13249-13254; first published October 12, 2015. https://doi.org/10.1073/pnas.1518874112
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    Myocardial NF-κB activation is essential for zebrafish heart regeneration

    Ravi Karra, Anne K. Knecht, Kazu Kikuchi, and Kenneth D. Poss

    PNAS October 27, 2015 112 (43) 13255-13260; first published October 15, 2015. https://doi.org/10.1073/pnas.1511209112

• Ecology

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    Medieval warming initiated exceptionally large wildfire outbreaks in the Rocky Mountains

    • From the Cover

    W. John Calder, Dusty Parker, Cody J. Stopka, Gonzalo Jiménez-Moreno, and Bryan N. Shuman

    PNAS October 27, 2015 112 (43) 13261-13266; first published October 5, 2015. https://doi.org/10.1073/pnas.1500796112

    See companion article:

    • Taking time to consider the causes and consequences of large wildfires

      - Oct 27, 2015
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    Lianas reduce carbon accumulation and storage in tropical forests

    Geertje M. F. van der Heijden, Jennifer S. Powers, and Stefan A. Schnitzer

    PNAS October 27, 2015 112 (43) 13267-13271; first published October 12, 2015. https://doi.org/10.1073/pnas.1504869112

    See companion article:

    • Reply to Verbeeck and Kearsley: Addressing the challenges of including lianas in global vegetation models

      - Jan 05, 2016
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    Global alteration of ocean ecosystem functioning due to increasing human CO₂ emissions

    • From the Cover

    Ivan Nagelkerken and Sean D. Connell

    PNAS October 27, 2015 112 (43) 13272-13277; first published October 12, 2015. https://doi.org/10.1073/pnas.1510856112
  • Open Access

    Cable bacteria generate a firewall against euxinia in seasonally hypoxic basins

    Dorina Seitaj, Regina Schauer, Fatimah Sulu-Gambari, Silvia Hidalgo-Martinez, Sairah Y. Malkin, Laurine D. W. Burdorf, Caroline P. Slomp, and Filip J. R. Meysman

    PNAS October 27, 2015 112 (43) 13278-13283; first published October 7, 2015. https://doi.org/10.1073/pnas.1510152112

• Evolution

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    Complex constraints on allometry revealed by artificial selection on the wing of Drosophila melanogaster

    • From the Cover

    Geir H. Bolstad, Jason A. Cassara, Eladio Márquez, Thomas F. Hansen, Kim van der Linde, David Houle, and Christophe Pélabon

    PNAS October 27, 2015 112 (43) 13284-13289; first published September 14, 2015. https://doi.org/10.1073/pnas.1505357112

    See companion article:

    • Evolvability and nonevolvability of allometric slopes

      - Nov 03, 2015
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    Coevolution of parasite virulence and host mating strategies

    • From the Cover

    Ben Ashby and Michael Boots

    PNAS October 27, 2015 112 (43) 13290-13295; first published October 1, 2015. https://doi.org/10.1073/pnas.1508397112

    See companion article:

    • When sex makes you sick

      - Oct 27, 2015
  • Open Access

    Bantu expansion shows that habitat alters the route and pace of human dispersals

    • From the Cover

    Rebecca Grollemund, Simon Branford, Koen Bostoen, Andrew Meade, Chris Venditti, and Mark Pagel

    PNAS October 27, 2015 112 (43) 13296-13301; first published September 14, 2015. https://doi.org/10.1073/pnas.1503793112

    See companion article:

    • Bantu history: Big advance, although with a chronological contradiction

      - Nov 03, 2015
  • Open Access

    DNA capture reveals transoceanic gene flow in endangered river sharks

    Chenhong Li, Shannon Corrigan, Lei Yang, Nicolas Straube, Mark Harris, Michael Hofreiter, William T. White, and Gavin J. P. Naylor

    PNAS October 27, 2015 112 (43) 13302-13307; first published October 12, 2015. https://doi.org/10.1073/pnas.1508735112

• Genetics

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    Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

    Fleur Weeber, Marc van de Wetering, Marlous Hoogstraat, Krijn K. Dijkstra, Oscar Krijgsman, Thomas Kuilman, Christa G. M. Gadellaa-van Hooijdonk, Daphne L. van der Velden, Daniel S. Peeper, Edwin P. J. G. Cuppen, Robert G. Vries, Hans Clevers, and Emile E. Voest

    PNAS October 27, 2015 112 (43) 13308-13311; first published October 12, 2015. https://doi.org/10.1073/pnas.1516689112

• Immunology and Inflammation

  • Open Access

    CD31 signals confer immune privilege to the vascular endothelium

    Kenneth Cheung, Liang Ma, Guosu Wang, David Coe, Riccardo Ferro, Marco Falasca, Christopher D. Buckley, Claudio Mauro, and Federica M. Marelli-Berg

    PNAS October 27, 2015 112 (43) E5815-E5824; first published September 21, 2015. https://doi.org/10.1073/pnas.1509627112

    See companion article:

    • Soothing touch of CD31 protects endothelium during cellular immune responses

      - Oct 27, 2015
  • Open Access

    IκBζ is a key driver in the development of psoriasis

    Claus Johansen, Maike Mose, Pernille Ommen, Trine Bertelsen, Hanne Vinter, Stephan Hailfinger, Sebastian Lorscheid, Klaus Schulze-Osthoff, and Lars Iversen

    PNAS October 27, 2015 112 (43) E5825-E5833; first published October 12, 2015. https://doi.org/10.1073/pnas.1509971112
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    The HLA-G cycle provides for both NK tolerance and immunity at the maternal–fetal interface

    Tamara Tilburgs, J. Henry Evans, Ângela C. Crespo, and Jack L. Strominger

    PNAS October 27, 2015 112 (43) 13312-13317; first published October 12, 2015. https://doi.org/10.1073/pnas.1517724112
  • Open Access

    N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes

    Niyun Jin, Yang Wang, Frances Crawford, Janice White, Philippa Marrack, Shaodong Dai, and John W. Kappler

    PNAS October 27, 2015 112 (43) 13318-13323; first published October 9, 2015. https://doi.org/10.1073/pnas.1517862112
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    Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3

    J. Philip Nance, Simon Bélanger, Robert J. Johnston, Joyce K. Hu, Toshitada Takemori, and Shane Crotty

    PNAS October 27, 2015 112 (43) 13324-13329; first published October 12, 2015. https://doi.org/10.1073/pnas.1507312112
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    IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice

    Mathias Schmaler, Maria A. S. Broggi, Nadège Lagarde, Benjamin F. Stöcklin, Carolyn G. King, Daniela Finke, and Simona W. Rossi

    PNAS October 27, 2015 112 (43) 13330-13335; first published October 8, 2015. https://doi.org/10.1073/pnas.1510045112

• Medical Sciences

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    Noninvasive monitoring of infection and rejection after lung transplantation

    Iwijn De Vlaminck, Lance Martin, Michael Kertesz, Kapil Patel, Mark Kowarsky, Calvin Strehl, Garrett Cohen, Helen Luikart, Norma F. Neff, Jennifer Okamoto, Mark R. Nicolls, David Cornfield, David Weill, Hannah Valantine, Kiran K. Khush, and Stephen R. Quake

    PNAS October 27, 2015 112 (43) 13336-13341; first published October 12, 2015. https://doi.org/10.1073/pnas.1517494112
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    Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals

    Helen He Zhu, Xiaolin Luo, Kaiqing Zhang, Jian Cui, Huifang Zhao, Zhongzhong Ji, Zhicheng Zhou, Jufang Yao, Lifan Zeng, Kaihong Ji, Wei-Qiang Gao, Zhong-Yin Zhang, and Gen-Sheng Feng

    PNAS October 27, 2015 112 (43) 13342-13347; first published October 12, 2015. https://doi.org/10.1073/pnas.1507599112

• Microbiology

  • Open Access

    E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress

    Christina Maksymiuk, Anand Balakrishnan, Ruslana Bryk, Kyu Y. Rhee, and Carl F. Nathan

    PNAS October 27, 2015 112 (43) E5834-E5843; first published October 1, 2015. https://doi.org/10.1073/pnas.1510932112

    See companion article:

    • Metabolic plasticity of central carbon metabolism protects mycobacteria

      - Oct 27, 2015
  • Open Access

    Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants

    Clarissa S. Sit, Antonio C. Ruzzini, Ethan B. Van Arnam, Timothy R. Ramadhar, Cameron R. Currie, and Jon Clardy

    PNAS October 27, 2015 112 (43) 13150-13154; first published October 5, 2015. https://doi.org/10.1073/pnas.1515348112
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    Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone

    Wieland Steinchen, Jan S. Schuhmacher, Florian Altegoer, Christopher D. Fage, Vasundara Srinivasan, Uwe Linne, Mohamed A. Marahiel, and Gert Bange

    PNAS October 27, 2015 112 (43) 13348-13353; first published October 12, 2015. https://doi.org/10.1073/pnas.1505271112

• Neuroscience

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    Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease

    William A. Beltran, Artur V. Cideciyan, Simone Iwabe, Malgorzata Swider, Mychajlo S. Kosyk, Kendra McDaid, Inna Martynyuk, Gui-Shuang Ying, James Shaffer, Wen-Tao Deng, Sanford L. Boye, Alfred S. Lewin, William W. Hauswirth, Samuel G. Jacobson, and Gustavo D. Aguirre

    PNAS October 27, 2015 112 (43) E5844-E5853; first published October 12, 2015. https://doi.org/10.1073/pnas.1509914112
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    Neural substrate for higher-order learning in an insect: Mushroom bodies are necessary for configural discriminations

    Jean-Marc Devaud, Thomas Papouin, Julie Carcaud, Jean-Christophe Sandoz, Bernd Grünewald, and Martin Giurfa

    PNAS October 27, 2015 112 (43) E5854-E5862; first published October 12, 2015. https://doi.org/10.1073/pnas.1508422112
  • Open Access

    Systemic, postsymptomatic antisense oligonucleotide rescues motor unit maturation delay in a new mouse model for type II/III spinal muscular atrophy

    Laurent P. Bogdanik, Melissa A. Osborne, Crystal Davis, Whitney P. Martin, Andrew Austin, Frank Rigo, C. Frank Bennett, and Cathleen M. Lutz

    PNAS October 27, 2015 112 (43) E5863-E5872; first published October 12, 2015. https://doi.org/10.1073/pnas.1509758112
  • Open Access

    Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography

    Bolek Zapiec and Peter Mombaerts

    PNAS October 27, 2015 112 (43) E5873-E5882; first published October 8, 2015. https://doi.org/10.1073/pnas.1512135112
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    Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation

    Natasha K. Hussain, Gareth M. Thomas, Junjie Luo, and Richard L. Huganir

    PNAS October 27, 2015 112 (43) E5883-E5890; first published October 12, 2015. https://doi.org/10.1073/pnas.1518382112
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    NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury

    Zhaoyang Yang, Aifeng Zhang, Hongmei Duan, Sa Zhang, Peng Hao, Keqiang Ye, Yi E. Sun, and Xiaoguang Li

    PNAS October 27, 2015 112 (43) 13354-13359; first published October 12, 2015. https://doi.org/10.1073/pnas.1510194112

    See companion article:

    • Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury

      - Oct 27, 2015
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    Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury

    Hongmei Duan, Weihong Ge, Aifeng Zhang, Yue Xi, Zhihua Chen, Dandan Luo, Yin Cheng, Kevin S. Fan, Steve Horvath, Michael V. Sofroniew, Liming Cheng, Zhaoyang Yang, Yi E. Sun, and Xiaoguang Li

    PNAS October 27, 2015 112 (43) 13360-13365; first published October 12, 2015. https://doi.org/10.1073/pnas.1510176112

    See companion article:

    • NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury

      - Oct 27, 2015
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    SPARC triggers a cell-autonomous program of synapse elimination

    Francisco J. López-Murcia, Beatrice Terni, and Artur Llobet

    PNAS October 27, 2015 112 (43) 13366-13371; first published September 29, 2015. https://doi.org/10.1073/pnas.1512202112

• Physiology

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    Unconstrained muscle-tendon workloops indicate resonance tuning as a mechanism for elastic limb behavior during terrestrial locomotion

    Benjamin D. Robertson and Gregory S. Sawicki

    PNAS October 27, 2015 112 (43) E5891-E5898; first published October 12, 2015. https://doi.org/10.1073/pnas.1500702112

• Plant Biology

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    Auxin signaling modules regulate maize inflorescence architecture

    Mary Galli, Qiujie Liu, Britney L. Moss, Simon Malcomber, Wei Li, Craig Gaines, Silvia Federici, Jessica Roshkovan, Robert Meeley, Jennifer L. Nemhauser, and Andrea Gallavotti

    PNAS October 27, 2015 112 (43) 13372-13377; first published October 13, 2015. https://doi.org/10.1073/pnas.1516473112
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    Intercellular communication in Arabidopsis thaliana pollen discovered via AHG3 transcript movement from the vegetative cell to sperm

    Hua Jiang, Jun Yi, Leonor C. Boavida, Yuan Chen, Jörg D. Becker, Claudia Köhler, and Sheila McCormick

    PNAS October 27, 2015 112 (43) 13378-13383; first published October 14, 2015. https://doi.org/10.1073/pnas.1510854112
  • Open Access

    Mechanism for rapid passive-dynamic prey capture in a pitcher plant

    Ulrike Bauer, Marion Paulin, Daniel Robert, and Gregory P. Sutton

    PNAS October 27, 2015 112 (43) 13384-13389; first published October 5, 2015. https://doi.org/10.1073/pnas.1510060112
  • Open Access

    Algal ancestor of land plants was preadapted for symbiosis

    Pierre-Marc Delaux, Guru V. Radhakrishnan, Dhileepkumar Jayaraman, Jitender Cheema, Mathilde Malbreil, Jeremy D. Volkening, Hiroyuki Sekimoto, Tomoaki Nishiyama, Michael Melkonian, Lisa Pokorny, Carl J. Rothfels, Heike Winter Sederoff, Dennis W. Stevenson, Barbara Surek, Yong Zhang, Michael R. Sussman, Christophe Dunand, Richard J. Morris, Christophe Roux, Gane Ka-Shu Wong, Giles E. D. Oldroyd, and Jean-Michel Ané

    PNAS October 27, 2015 112 (43) 13390-13395; first published October 5, 2015. https://doi.org/10.1073/pnas.1515426112

• Population Biology

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    Cross-immunity between strains explains the dynamical pattern of paramyxoviruses

    Samit Bhattacharyya, Per H. Gesteland, Kent Korgenski, Ottar N. Bjørnstad, and Frederick R. Adler

    PNAS October 27, 2015 112 (43) 13396-13400; first published October 12, 2015. https://doi.org/10.1073/pnas.1516698112

• Psychological and Cognitive Sciences

  • Open Access

    Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals

    Christoph Teufel, Naresh Subramaniam, Veronika Dobler, Jesus Perez, Johanna Finnemann, Puja R. Mehta, Ian M. Goodyer, and Paul C. Fletcher

    PNAS October 27, 2015 112 (43) 13401-13406; first published October 12, 2015. https://doi.org/10.1073/pnas.1503916112
  • Open Access

    Receipt of reward leads to altered estimation of effort

    Arezoo Pooresmaeili, Aurel Wannig, and Raymond J. Dolan

    PNAS October 27, 2015 112 (43) 13407-13410; first published October 12, 2015. https://doi.org/10.1073/pnas.1507527112

• Sustainability Science

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    Historical dynamics in ecosystem service bundles

    Delphine Renard, Jeanine M. Rhemtulla, and Elena M. Bennett

    PNAS October 27, 2015 112 (43) 13411-13416; first published October 12, 2015. https://doi.org/10.1073/pnas.1502565112