Proceedings of the National Academy of Sciences: 112 (44)

New Research In

November 03, 2015; vol. 112 no. 44

This Week in PNAS

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In This Issue
PNAS November 3, 2015 112 (44) 13417-13418; https://doi.org/10.1073/iti4415112

Letters (Online Only)

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Processes affecting extinction risk in the laboratory and in nature
J. Timothy Wootton and Catherine A. Pfister

PNAS November 3, 2015 112 (44) E5903; first published October 19, 2015. https://doi.org/10.1073/pnas.1516561112
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Reply to Wootton and Pfister: The search for general context should include synthesis with laboratory model systems
Ruth A. Hufbauer, Marianna Szűcs, Emily Kasyon, Courtney Youngberg, Michael J. Koontz, Christopher Richards, Ty Tuff, and Brett A. Melbourne

PNAS November 3, 2015 112 (44) E5904; first published October 19, 2015. https://doi.org/10.1073/pnas.1517210112
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Rescue can avert extinction in a novel environment
- Aug 03, 2015
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Inquiry into congruencies and trade-offs among conservation objectives requires a consistent typology of homogeneous types
Thomas Kirchhoff

PNAS November 3, 2015 112 (44) E5905; first published October 19, 2015. https://doi.org/10.1073/pnas.1517860112
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Reply to Kirchhoff: Homogenous and mutually exclusive conservation typologies are neither possible nor desirable
Daniel S. Karp, Chase D. Mendenhall, Elizabeth Callaway, Luke O. Frishkoff, Peter M. Kareiva, Paul R. Ehrlich, and Gretchen C. Daily

PNAS November 3, 2015 112 (44) E5906; first published October 19, 2015. https://doi.org/10.1073/pnas.1518479112
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Confronting conservation values
- Aug 17, 2015

Opinion

Leading scientists discuss current issues.

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Opinion: Focus on preclinical sex differences will not address women’s and men’s health disparities
Front Matter
Sarah S. Richardson, Meredith Reiches, Heather Shattuck-Heidorn, Michelle Lynne LaBonte, and Theresa Consoli

PNAS November 3, 2015 112 (44) 13419-13420; https://doi.org/10.1073/pnas.1516958112

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: Taking evolution to the clinic
Front Matter
Elie Dolgin

PNAS November 3, 2015 112 (44) 13421-13422; https://doi.org/10.1073/pnas.1516954112

Retrospective

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Developmental biologist Eric H. Davidson, 1937–2015
Leroy Hood and Ellen V. Rothenberg

PNAS November 3, 2015 112 (44) 13423-13425; first published October 23, 2015. https://doi.org/10.1073/pnas.1518876112

Commentaries

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Evolvability and nonevolvability of allometric slopes
Jon F. Harrison

PNAS November 3, 2015 112 (44) 13426-13427; first published October 23, 2015. https://doi.org/10.1073/pnas.1517621112
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Complex constraints on allometry
- Sep 14, 2015
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Bantu history: Big advance, although with a chronological contradiction
Christopher Ehret

PNAS November 3, 2015 112 (44) 13428-13429; first published October 28, 2015. https://doi.org/10.1073/pnas.1517381112
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Habitat alters route and pace of human dispersals
- Sep 14, 2015
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Structural revelations of the human proton channel
Thomas E. DeCoursey

PNAS November 3, 2015 112 (44) 13430-13431; first published October 14, 2015. https://doi.org/10.1073/pnas.1518486112
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Resting state of hHv1 in a lipid bilayer
- Oct 06, 2015
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Tracking Austronesian expansion into the Pacific via the paper mulberry plant
Elizabeth A. Matisoo-Smith

PNAS November 3, 2015 112 (44) 13432-13433; first published October 23, 2015. https://doi.org/10.1073/pnas.1518576112
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Pacific paper mulberry phylogeography
- Oct 05, 2015
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Latent hydrocarbons from cyanobacteria
David L. Valentine and Christopher M. Reddy

PNAS November 3, 2015 112 (44) 13434-13435; first published October 19, 2015. https://doi.org/10.1073/pnas.1518485112
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Cyanobacterial hydrocarbon production in oceans
- Oct 05, 2015

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS November 3, 2015 112 (44) 13436-13438; https://doi.org/10.1073/pnas.ss11244

Perspective

Open Access
Accelerating scientific publication in biology
Ronald D. Vale

PNAS November 3, 2015 112 (44) 13439-13446; first published October 27, 2015. https://doi.org/10.1073/pnas.1511912112

Physical Sciences

Applied Mathematics
- Open Access
  Clique topology reveals intrinsic geometric structure in neural correlations
  Chad Giusti, Eva Pastalkova, Carina Curto, and Vladimir Itskov
  
  PNAS November 3, 2015 112 (44) 13455-13460; first published October 20, 2015. https://doi.org/10.1073/pnas.1506407112
- Open Access
  Emergence of system roles in normative neurodevelopment
  Shi Gu, Theodore D. Satterthwaite, John D. Medaglia, Muzhi Yang, Raquel E. Gur, Ruben C. Gur, and Danielle S. Bassett
  
  PNAS November 3, 2015 112 (44) 13681-13686; first published October 19, 2015. https://doi.org/10.1073/pnas.1502829112
Astronomy
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  Probing exoplanet clouds with optical phase curves
  Antonio García Muñoz and Kate G. Isaak
  
  PNAS November 3, 2015 112 (44) 13461-13466; first published October 21, 2015. https://doi.org/10.1073/pnas.1509135112
Chemistry
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  Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription
  Danya J. Martell, Chandra P. Joshi, Ahmed Gaballa, Ace George Santiago, Tai-Yen Chen, Won Jung, John D. Helmann, and Peng Chen
  
  PNAS November 3, 2015 112 (44) 13467-13472; first published October 19, 2015. https://doi.org/10.1073/pnas.1515231112
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  Nanopurification of silicon from 84% to 99.999% purity with a simple and scalable process
  From the Cover
  
  Linqi Zong, Bin Zhu, Zhenda Lu, Yingling Tan, Yan Jin, Nian Liu, Yue Hu, Shuai Gu, Jia Zhu, and Yi Cui
  
  PNAS November 3, 2015 112 (44) 13473-13477; first published October 19, 2015. https://doi.org/10.1073/pnas.1513012112
Earth, Atmospheric, and Planetary Sciences
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  A distinct pathway for tetrahymanol synthesis in bacteria
  Amy B. Banta, Jeremy H. Wei, and Paula V. Welander
  
  PNAS November 3, 2015 112 (44) 13478-13483; first published October 19, 2015. https://doi.org/10.1073/pnas.1511482112
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  Sulfur radical species form gold deposits on Earth
  Gleb S. Pokrovski, Maria A. Kokh, Damien Guillaume, Anastassia Y. Borisova, Pascal Gisquet, Jean-Louis Hazemann, Eric Lahera, William Del Net, Olivier Proux, Denis Testemale, Volker Haigis, Romain Jonchière, Ari P. Seitsonen, Guillaume Ferlat, Rodolphe Vuilleumier, Antonino Marco Saitta, Marie-Christine Boiron, and Jean Dubessy
  
  PNAS November 3, 2015 112 (44) 13484-13489; first published October 12, 2015. https://doi.org/10.1073/pnas.1506378112
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  El Niño−Southern Oscillation frequency cascade
  Malte F. Stuecker, Fei-Fei Jin, and Axel Timmermann
  
  PNAS November 3, 2015 112 (44) 13490-13495; first published October 19, 2015. https://doi.org/10.1073/pnas.1508622112
- Open Access
  Glacial reduction and millennial-scale variations in Drake Passage throughflow
  Frank Lamy, Helge W. Arz, Rolf Kilian, Carina B. Lange, Lester Lembke-Jene, Marc Wengler, Jérôme Kaiser, Oscar Baeza-Urrea, Ian R. Hall, Naomi Harada, and Ralf Tiedemann
  
  PNAS November 3, 2015 112 (44) 13496-13501; first published September 28, 2015. https://doi.org/10.1073/pnas.1509203112
Engineering
- Open Access
  Cyclic deformation leads to defect healing and strengthening of small-volume metal crystals
  Zhang-Jie Wang, Qing-Jie Li, Yi-Nan Cui, Zhan-Li Liu, Evan Ma, Ju Li, Jun Sun, Zhuo Zhuang, Ming Dao, Zhi-Wei Shan, and Subra Suresh
  
  PNAS November 3, 2015 112 (44) 13502-13507; first published October 19, 2015. https://doi.org/10.1073/pnas.1518200112
Environmental Sciences
- Open Access
  Carbon choices determine US cities committed to futures below sea level
  Benjamin H. Strauss, Scott Kulp, and Anders Levermann
  
  PNAS November 3, 2015 112 (44) 13508-13513; first published October 12, 2015. https://doi.org/10.1073/pnas.1511186112
  
  See companion article:
  Long-term sea level projections and coastal cities
  - Feb 24, 2016
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  The future of airborne sulfur-containing particles in the absence of fossil fuel sulfur dioxide emissions
  Véronique Perraud, Jeremy R. Horne, Andrew S. Martinez, Jaroslaw Kalinowski, Simone Meinardi, Matthew L. Dawson, Lisa M. Wingen, Donald Dabdub, Donald R. Blake, R. Benny Gerber, and Barbara J. Finlayson-Pitts
  
  PNAS November 3, 2015 112 (44) 13514-13519; first published October 19, 2015. https://doi.org/10.1073/pnas.1510743112
Physics
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  Pressure-tuned quantum criticality in the antiferromagnetic Kondo semimetal CeNi_2−δAs₂
  Yongkang Luo, F. Ronning, N. Wakeham, Xin Lu, Tuson Park, Z.-A. Xu, and J. D. Thompson
  
  PNAS November 3, 2015 112 (44) 13520-13524; first published October 19, 2015. https://doi.org/10.1073/pnas.1509581112
Sustainability Science
- Open Access
  Solar energy development impacts on land cover change and protected areas
  Rebecca R. Hernandez, Madison K. Hoffacker, Michelle L. Murphy-Mariscal, Grace C. Wu, and Michael F. Allen
  
  PNAS November 3, 2015 112 (44) 13579-13584; first published October 19, 2015. https://doi.org/10.1073/pnas.1517656112

Biological Sciences

Anthropology
- Open Access
  A holistic picture of Austronesian migrations revealed by phylogeography of Pacific paper mulberry
  From the Cover
  
  Chi-Shan Chang, Hsiao-Lei Liu, Ximena Moncada, Andrea Seelenfreund, Daniela Seelenfreund, and Kuo-Fang Chung
  
  PNAS November 3, 2015 112 (44) 13537-13542; first published October 5, 2015. https://doi.org/10.1073/pnas.1503205112
  
  See companion article:
  Paper mulberry and Austronesian expansions
  - Oct 23, 2015
Applied Biological Sciences
- Open Access
  Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution
  Xiao-Guang Chen, Xuanting Jiang, Jinbao Gu, Meng Xu, Yang Wu, Yuhua Deng, Chi Zhang, Mariangela Bonizzoni, Wannes Dermauw, John Vontas, Peter Armbruster, Xin Huang, Yulan Yang, Hao Zhang, Weiming He, Hongjuan Peng, Yongfeng Liu, Kun Wu, Jiahua Chen, Manolis Lirakis, Pantelis Topalis, Thomas Van Leeuwen, Andrew Brantley Hall, Xiaofang Jiang, Chevon Thorpe, Rachel Lockridge Mueller, Cheng Sun, Robert Michael Waterhouse, Guiyun Yan, Zhijian Jake Tu, Xiaodong Fang, and Anthony A. James
  
  PNAS November 3, 2015 112 (44) E5907-E5915; first published October 19, 2015. https://doi.org/10.1073/pnas.1516410112
Biochemistry
- Open Access
  Transcriptomic characterization of fibrolamellar hepatocellular carcinoma
  Elana P. Simon, Catherine A. Freije, Benjamin A. Farber, Gadi Lalazar, David G. Darcy, Joshua N. Honeyman, Rachel Chiaroni-Clarke, Brian D. Dill, Henrik Molina, Umesh K. Bhanot, Michael P. La Quaglia, Brad R. Rosenberg, and Sanford M. Simon
  
  PNAS November 3, 2015 112 (44) E5916-E5925; first published October 21, 2015. https://doi.org/10.1073/pnas.1424894112
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  Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription
  Danya J. Martell, Chandra P. Joshi, Ahmed Gaballa, Ace George Santiago, Tai-Yen Chen, Won Jung, John D. Helmann, and Peng Chen
  
  PNAS November 3, 2015 112 (44) 13467-13472; first published October 19, 2015. https://doi.org/10.1073/pnas.1515231112
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  Structure of an RNA polymerase II preinitiation complex
  Kenji Murakami, Kuang-Lei Tsai, Nir Kalisman, David A. Bushnell, Francisco J. Asturias, and Roger D. Kornberg
  
  PNAS November 3, 2015 112 (44) 13543-13548; first published October 19, 2015. https://doi.org/10.1073/pnas.1518255112
Biophysics and Computational Biology
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  Resting state of the human proton channel dimer in a lipid bilayer
  From the Cover
  
  Qufei Li, Rong Shen, Jeremy S. Treger, Sherry S. Wanderling, Wieslawa Milewski, Klaudia Siwowska, Francisco Bezanilla, and Eduardo Perozo
  
  PNAS November 3, 2015 112 (44) E5926-E5935; first published October 6, 2015. https://doi.org/10.1073/pnas.1515043112
  
  See companion article:
  Structural revelations of the human proton channel
  - Oct 14, 2015
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  Preventing fibril formation of a protein by selective mutation
  Gia G. Maisuradze, Jordi Medina, Khatuna Kachlishvili, Pawel Krupa, Magdalena A. Mozolewska, Pau Martin-Malpartida, Luka Maisuradze, Maria J. Macias, and Harold A. Scheraga
  
  PNAS November 3, 2015 112 (44) 13549-13554; first published October 19, 2015. https://doi.org/10.1073/pnas.1518298112
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  Targeted binding of nucleocapsid protein transforms the folding landscape of HIV-1 TAR RNA
  Micah J. McCauley, Ioulia Rouzina, Kelly A. Manthei, Robert J. Gorelick, Karin Musier-Forsyth, and Mark C. Williams
  
  PNAS November 3, 2015 112 (44) 13555-13560; first published October 19, 2015. https://doi.org/10.1073/pnas.1510100112
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  Diverse oligomeric states of CEACAM IgV domains
  Daniel A. Bonsor, Sebastian Günther, Robert Beadenkopf, Dorothy Beckett, and Eric J. Sundberg
  
  PNAS November 3, 2015 112 (44) 13561-13566; first published October 19, 2015. https://doi.org/10.1073/pnas.1509511112
- Open Access
  From residue coevolution to protein conformational ensembles and functional dynamics
  Ludovico Sutto, Simone Marsili, Alfonso Valencia, and Francesco Luigi Gervasio
  
  PNAS November 3, 2015 112 (44) 13567-13572; first published October 20, 2015. https://doi.org/10.1073/pnas.1508584112
Cell Biology
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  Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality
  Christopher T. Pappas, Rachel M. Mayfield, Christine Henderson, Nima Jamilpour, Cathleen Cover, Zachary Hernandez, Kirk R. Hutchinson, Miensheng Chu, Ki-Hwan Nam, Jose M. Valdez, Pak Kin Wong, Henk L. Granzier, and Carol C. Gregorio
  
  PNAS November 3, 2015 112 (44) 13573-13578; first published October 20, 2015. https://doi.org/10.1073/pnas.1508273112
Developmental Biology
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  Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells
  Haixia Chen, Renpeng Guo, Qian Zhang, Hongchao Guo, Meng Yang, Zhenfeng Wu, Shan Gao, Lin Liu, and Lingyi Chen
  
  PNAS November 3, 2015 112 (44) E5936-E5943; first published October 19, 2015. https://doi.org/10.1073/pnas.1516319112
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  VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish
  Lasse D. Jensen, Masaki Nakamura, Lars Bräutigam, Xuri Li, Yizhi Liu, Nilesh J. Samani, and Yihai Cao
  
  PNAS November 3, 2015 112 (44) E5944-E5953; first published October 19, 2015. https://doi.org/10.1073/pnas.1510245112
- Open Access
  Coevolutionary patterning of teeth and taste buds
  Ryan F. Bloomquist, Nicholas F. Parnell, Kristine A. Phillips, Teresa E. Fowler, Tian Y. Yu, Paul T. Sharpe, and J. Todd Streelman
  
  PNAS November 3, 2015 112 (44) E5954-E5962; first published October 19, 2015. https://doi.org/10.1073/pnas.1514298112
Ecology
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  Vertebrate community on an ice-age Caribbean island
  David W. Steadman, Nancy A. Albury, Brian Kakuk, Jim I. Mead, J. Angel Soto-Centeno, Hayley M. Singleton, and Janet Franklin
  
  PNAS November 3, 2015 112 (44) E5963-E5971; first published October 19, 2015. https://doi.org/10.1073/pnas.1516490112
- Open Access
  Solar energy development impacts on land cover change and protected areas
  Rebecca R. Hernandez, Madison K. Hoffacker, Michelle L. Murphy-Mariscal, Grace C. Wu, and Michael F. Allen
  
  PNAS November 3, 2015 112 (44) 13579-13584; first published October 19, 2015. https://doi.org/10.1073/pnas.1517656112
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  Deciduous forest responses to temperature, precipitation, and drought imply complex climate change impacts
  Yingying Xie, Xiaojing Wang, and John A. Silander Jr.
  
  PNAS November 3, 2015 112 (44) 13585-13590; first published October 19, 2015. https://doi.org/10.1073/pnas.1509991112
Environmental Sciences
- Open Access
  Functional group-specific traits drive phytoplankton dynamics in the oligotrophic ocean
  Harriet Alexander, Mónica Rouco, Sheean T. Haley, Samuel T. Wilson, David M. Karl, and Sonya T. Dyhrman
  
  PNAS November 3, 2015 112 (44) E5972-E5979; first published October 12, 2015. https://doi.org/10.1073/pnas.1518165112
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  Contribution of cyanobacterial alkane production to the ocean hydrocarbon cycle
  From the Cover
  
  David J. Lea-Smith, Steven J. Biller, Matthew P. Davey, Charles A. R. Cotton, Blanca M. Perez Sepulveda, Alexandra V. Turchyn, David J. Scanlan, Alison G. Smith, Sallie W. Chisholm, and Christopher J. Howe
  
  PNAS November 3, 2015 112 (44) 13591-13596; first published October 5, 2015. https://doi.org/10.1073/pnas.1507274112
  
  See companion article:
  Latent hydrocarbons from cyanobacteria
  - Oct 19, 2015
Evolution
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  Sequential divergence and the multiplicative origin of community diversity
  Glen R. Hood, Andrew A. Forbes, Thomas H. Q. Powell, Scott P. Egan, Gabriela Hamerlinck, James J. Smith, and Jeffrey L. Feder
  
  PNAS November 3, 2015 112 (44) E5980-E5989; first published October 23, 2015. https://doi.org/10.1073/pnas.1424717112
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  Antipredator defenses predict diversification rates
  Kevin Arbuckle and Michael P. Speed
  
  PNAS November 3, 2015 112 (44) 13597-13602; first published October 19, 2015. https://doi.org/10.1073/pnas.1509811112
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  The evolution of parental cooperation in birds
  Vladimír Remeš, Robert P. Freckleton, Jácint Tökölyi, András Liker, and Tamás Székely
  
  PNAS November 3, 2015 112 (44) 13603-13608; first published October 19, 2015. https://doi.org/10.1073/pnas.1512599112
- Open Access
  Population genomics of Mycobacterium tuberculosis in the Inuit
  Robyn S. Lee, Nicolas Radomski, Jean-Francois Proulx, Ines Levade, B. Jesse Shapiro, Fiona McIntosh, Hafid Soualhine, Dick Menzies, and Marcel A. Behr
  
  PNAS November 3, 2015 112 (44) 13609-13614; first published October 19, 2015. https://doi.org/10.1073/pnas.1507071112
Genetics
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  Determinants of spontaneous mutation in the bacterium Escherichia coli as revealed by whole-genome sequencing
  Patricia L. Foster, Heewook Lee, Ellen Popodi, Jesse P. Townes, and Haixu Tang
  
  PNAS November 3, 2015 112 (44) E5990-E5999; first published October 12, 2015. https://doi.org/10.1073/pnas.1512136112
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  Mitochondrial retrograde signaling regulates neuronal function
  Umut Cagin, Olivia F. Duncan, Ariana P. Gatt, Marc S. Dionne, Sean T. Sweeney, and Joseph M. Bateman
  
  PNAS November 3, 2015 112 (44) E6000-E6009; first published October 21, 2015. https://doi.org/10.1073/pnas.1505036112
- Open Access
  Genetic basis of transcriptome diversity in Drosophila melanogaster
  Wen Huang, Mary Anna Carbone, Michael M. Magwire, Jason A. Peiffer, Richard F. Lyman, Eric A. Stone, Robert R. H. Anholt, and Trudy F. C. Mackay
  
  PNAS November 3, 2015 112 (44) E6010-E6019; first published October 19, 2015. https://doi.org/10.1073/pnas.1519159112
- Open Access
  The human gene damage index as a gene-level approach to prioritizing exome variants
  Yuval Itan, Lei Shang, Bertrand Boisson, Etienne Patin, Alexandre Bolze, Marcela Moncada-Vélez, Eric Scott, Michael J. Ciancanelli, Fabien G. Lafaille, Janet G. Markle, Ruben Martinez-Barricarte, Sarah Jill de Jong, Xiao-Fei Kong, Patrick Nitschke, Aziz Belkadi, Jacinta Bustamante, Anne Puel, Stéphanie Boisson-Dupuis, Peter D. Stenson, Joseph G. Gleeson, David N. Cooper, Lluis Quintana-Murci, Jean-Michel Claverie, Shen-Ying Zhang, Laurent Abel, and Jean-Laurent Casanova
  
  PNAS November 3, 2015 112 (44) 13615-13620; first published October 19, 2015. https://doi.org/10.1073/pnas.1518646112
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  Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns
  James Y. Zou, Danny S. Park, Esteban G. Burchard, Dara G. Torgerson, Maria Pino-Yanes, Yun S. Song, Sriram Sankararaman, Eran Halperin, and Noah Zaitlen
  
  PNAS November 3, 2015 112 (44) 13621-13626; first published October 19, 2015. https://doi.org/10.1073/pnas.1501741112
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  Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance
  Yun-Qian Gao, Xin Chen, Pei Wang, Lei Lu, Wei Zhao, Chen Chen, Cai-Ping Chen, Tao Tao, Jie Sun, Yan-Yan Zheng, Jie Du, Chao-Jun Li, Zhen-Ji Gan, Xiang Gao, Hua-Qun Chen, and Min-Sheng Zhu
  
  PNAS November 3, 2015 112 (44) 13627-13632; first published October 20, 2015. https://doi.org/10.1073/pnas.1511448112
- Open Access
  Holocentromeres in Rhynchospora are associated with genome-wide centromere-specific repeat arrays interspersed among euchromatin
  André Marques, Tiago Ribeiro, Pavel Neumann, Jiří Macas, Petr Novák, Veit Schubert, Marco Pellino, Jörg Fuchs, Wei Ma, Markus Kuhlmann, Ronny Brandt, André L. L. Vanzela, Tomáš Beseda, Hana Šimková, Andrea Pedrosa-Harand, and Andreas Houben
  
  PNAS November 3, 2015 112 (44) 13633-13638; first published October 21, 2015. https://doi.org/10.1073/pnas.1512255112
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  Genetic structure in village dogs reveals a Central Asian domestication origin
  From the Cover
  
  Laura M. Shannon, Ryan H. Boyko, Marta Castelhano, Elizabeth Corey, Jessica J. Hayward, Corin McLean, Michelle E. White, Mounir Abi Said, Baddley A. Anita, Nono Ikombe Bondjengo, Jorge Calero, Ana Galov, Marius Hedimbi, Bulu Imam, Rajashree Khalap, Douglas Lally, Andrew Masta, Kyle C. Oliveira, Lucía Pérez, Julia Randall, Nguyen Minh Tam, Francisco J. Trujillo-Cornejo, Carlos Valeriano, Nathan B. Sutter, Rory J. Todhunter, Carlos D. Bustamante, and Adam R. Boyko
  
  PNAS November 3, 2015 112 (44) 13639-13644; first published October 19, 2015. https://doi.org/10.1073/pnas.1516215112
  
  See companion article:
  Reply to Wang et al: Central Asian origin of dogs
  - Apr 20, 2016
Immunology and Inflammation
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  Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus
  Martijn H. Brugman, Anna-Sophia Wiekmeijer, Marja van Eggermond, Ingrid Wolvers-Tettero, Anton W. Langerak, Edwin F. E. de Haas, Leonid V. Bystrykh, Jon J. van Rood, Gerald de Haan, Willem E. Fibbe, and Frank J. T. Staal
  
  PNAS November 3, 2015 112 (44) E6020-E6027; first published October 19, 2015. https://doi.org/10.1073/pnas.1519118112
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  Maternal CD4⁺ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission
  Kristy M. Bialas, Takayuki Tanaka, Dollnovan Tran, Valerie Varner, Eduardo Cisneros De La Rosa, Flavia Chiuppesi, Felix Wussow, Lisa Kattenhorn, Sheila Macri, Erika L. Kunz, Judy A. Estroff, Jennifer Kirchherr, Yujuan Yue, Qihua Fan, Michael Lauck, David H. O’Connor, Allison H. S. Hall, Alvarez Xavier, Don J. Diamond, Peter A. Barry, Amitinder Kaur, and Sallie R. Permar
  
  PNAS November 3, 2015 112 (44) 13645-13650; first published October 19, 2015. https://doi.org/10.1073/pnas.1511526112
Medical Sciences
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  Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens
  Inaugural Article
  
  Ryan M. Young, Tianyi Wu, Roland Schmitz, Moez Dawood, Wenming Xiao, James D. Phelan, Weihong Xu, Laurence Menard, Eric Meffre, Wing-Chung C. Chan, Elaine S. Jaffe, Randy D. Gascoyne, Elías Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M. Rimsza, and Louis M. Staudt
  
  PNAS November 3, 2015 112 (44) 13447-13454; first published October 19, 2015. https://doi.org/10.1073/pnas.1514944112
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  Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice
  Xianyang Zhang, Tengjiao Cui, Jinlin He, Haibo Wang, Renzhi Cai, Petra Popovics, Irving Vidaurre, Wei Sha, Janine Schmid, Barbara Ludwig, Norman L. Block, Stefan R. Bornstein, and Andrew V. Schally
  
  PNAS November 3, 2015 112 (44) 13651-13656; first published October 16, 2015. https://doi.org/10.1073/pnas.1518540112
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  An intrinsic mechanism of secreted protein aging and turnover
  Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Michael J. Mahan, Jeffrey W. Smith, and Jamey D. Marth
  
  PNAS November 3, 2015 112 (44) 13657-13662; first published October 21, 2015. https://doi.org/10.1073/pnas.1515464112
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  Dystrophin–glycoprotein complex regulates muscle nitric oxide production through mechanoregulation of AMPK signaling
  Joanne F. Garbincius and Daniel E. Michele
  
  PNAS November 3, 2015 112 (44) 13663-13668; first published October 19, 2015. https://doi.org/10.1073/pnas.1512991112
Microbiology
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  Cell-cycle progress in obligate predatory bacteria is dependent upon sequential sensing of prey recognition and prey quality cues
  Or Rotem, Zohar Pasternak, Eyal Shimoni, Eduard Belausov, Ziv Porat, Shmuel Pietrokovski, and Edouard Jurkevitch
  
  PNAS November 3, 2015 112 (44) E6028-E6037; first published October 20, 2015. https://doi.org/10.1073/pnas.1515749112
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  Comprehensive analysis reveals how single nucleotides contribute to noncoding RNA function in bacterial quorum sensing
  Steven T. Rutherford, Julie S. Valastyan, Thibaud Taillefumier, Ned S. Wingreen, and Bonnie L. Bassler
  
  PNAS November 3, 2015 112 (44) E6038-E6047; first published October 19, 2015. https://doi.org/10.1073/pnas.1518958112
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  A distinct pathway for tetrahymanol synthesis in bacteria
  Amy B. Banta, Jeremy H. Wei, and Paula V. Welander
  
  PNAS November 3, 2015 112 (44) 13478-13483; first published October 19, 2015. https://doi.org/10.1073/pnas.1511482112
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  Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria
  Tania K. Shishido, Jouni Jokela, Clara-Theresia Kolehmainen, David P. Fewer, Matti Wahlsten, Hao Wang, Leo Rouhiainen, Ermanno Rizzi, Gianluca De Bellis, Perttu Permi, and Kaarina Sivonen
  
  PNAS November 3, 2015 112 (44) 13669-13674; first published October 16, 2015. https://doi.org/10.1073/pnas.1510432112
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  Subdiffusive motion of bacteriophage in mucosal surfaces increases the frequency of bacterial encounters
  Jeremy J. Barr, Rita Auro, Nicholas Sam-Soon, Sam Kassegne, Gregory Peters, Natasha Bonilla, Mark Hatay, Sarah Mourtada, Barbara Bailey, Merry Youle, Ben Felts, Arlette Baljon, Jim Nulton, Peter Salamon, and Forest Rohwer
  
  PNAS November 3, 2015 112 (44) 13675-13680; first published October 19, 2015. https://doi.org/10.1073/pnas.1508355112
Neuroscience
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  Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes
  Robert Alberstein, Richard Grey, Austin Zimmet, David K. Simmons, and Mark L. Mayer
  
  PNAS November 3, 2015 112 (44) E6048-E6057; first published October 12, 2015. https://doi.org/10.1073/pnas.1513771112
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  High-speed spelling with a noninvasive brain–computer interface
  Xiaogang Chen, Yijun Wang, Masaki Nakanishi, Xiaorong Gao, Tzyy-Ping Jung, and Shangkai Gao
  
  PNAS November 3, 2015 112 (44) E6058-E6067; first published October 19, 2015. https://doi.org/10.1073/pnas.1508080112
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  Clique topology reveals intrinsic geometric structure in neural correlations
  Chad Giusti, Eva Pastalkova, Carina Curto, and Vladimir Itskov
  
  PNAS November 3, 2015 112 (44) 13455-13460; first published October 20, 2015. https://doi.org/10.1073/pnas.1506407112
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  Topographic representations of object size and relationships with numerosity reveal generalized quantity processing in human parietal cortex
  Ben M. Harvey, Alessio Fracasso, Natalia Petridou, and Serge O. Dumoulin
  
  PNAS November 3, 2015 112 (44) 13525-13530; first published October 19, 2015. https://doi.org/10.1073/pnas.1515414112
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  Emergence of system roles in normative neurodevelopment
  Shi Gu, Theodore D. Satterthwaite, John D. Medaglia, Muzhi Yang, Raquel E. Gur, Ruben C. Gur, and Danielle S. Bassett
  
  PNAS November 3, 2015 112 (44) 13681-13686; first published October 19, 2015. https://doi.org/10.1073/pnas.1502829112
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  Bursts of beta oscillation differentiate postperformance activity in the striatum and motor cortex of monkeys performing movement tasks
  Joseph Feingold, Daniel J. Gibson, Brian DePasquale, and Ann M. Graybiel
  
  PNAS November 3, 2015 112 (44) 13687-13692; first published October 12, 2015. https://doi.org/10.1073/pnas.1517629112
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  Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB₁ receptors on developing cortical neurons
  Adán de Salas-Quiroga, Javier Díaz-Alonso, Daniel García-Rincón, Floortje Remmers, David Vega, María Gómez-Cañas, Beat Lutz, Manuel Guzmán, and Ismael Galve-Roperh
  
  PNAS November 3, 2015 112 (44) 13693-13698; first published October 12, 2015. https://doi.org/10.1073/pnas.1514962112
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  Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
  Ali B. Rodgers, Christopher P. Morgan, N. Adrian Leu, and Tracy L. Bale
  
  PNAS November 3, 2015 112 (44) 13699-13704; first published October 19, 2015. https://doi.org/10.1073/pnas.1508347112
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  Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties
  Iulia Blesneac, Jean Chemin, Isabelle Bidaud, Sylvaine Huc-Brandt, Franck Vandermoere, and Philippe Lory
  
  PNAS November 3, 2015 112 (44) 13705-13710; first published October 19, 2015. https://doi.org/10.1073/pnas.1511740112
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  Synaptic circuits and their variations within different columns in the visual system of Drosophila
  Shin-ya Takemura, C. Shan Xu, Zhiyuan Lu, Patricia K. Rivlin, Toufiq Parag, Donald J. Olbris, Stephen Plaza, Ting Zhao, William T. Katz, Lowell Umayam, Charlotte Weaver, Harald F. Hess, Jane Anne Horne, Juan Nunez-Iglesias, Roxanne Aniceto, Lei-Ann Chang, Shirley Lauchie, Ashley Nasca, Omotara Ogundeyi, Christopher Sigmund, Satoko Takemura, Julie Tran, Carlie Langille, Kelsey Le Lacheur, Sari McLin, Aya Shinomiya, Dmitri B. Chklovskii, Ian A. Meinertzhagen, and Louis K. Scheffer
  
  PNAS November 3, 2015 112 (44) 13711-13716; first published October 19, 2015. https://doi.org/10.1073/pnas.1509820112
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  Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice
  Yumi Ueki, Matthew S. Wilken, Kristen E. Cox, Laura Chipman, Nikolas Jorstad, Kristen Sternhagen, Milesa Simic, Kristy Ullom, Masato Nakafuku, and Thomas A. Reh
  
  PNAS November 3, 2015 112 (44) 13717-13722; first published October 19, 2015. https://doi.org/10.1073/pnas.1510595112
Physiology
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  SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis
  Tiffany Fleet, Bin Zhang, Fumin Lin, Bokai Zhu, Subhamoy Dasgupta, Erin Stashi, Bryan Tackett, Sundararajah Thevananther, Kimal I. Rajapakshe, Naomi Gonzales, Adam Dean, Jianqiang Mao, Nikolai Timchenko, Anna Malovannaya, Jun Qin, Cristian Coarfa, Francesco DeMayo, Clifford C. Dacso, Charles E. Foulds, Bert W. O’Malley, and Brian York
  
  PNAS November 3, 2015 112 (44) E6068-E6077; first published October 20, 2015. https://doi.org/10.1073/pnas.1519073112
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  Digoxin derivatives with selectivity for the α2β3 isoform of Na,K-ATPase potently reduce intraocular pressure
  Adriana Katz, Daniel M. Tal, Dan Heller, Michael Habeck, Efrat Ben Zeev, Bilal Rabah, Yaniv Bar Kana, Arie L. Marcovich, and Steven J. D. Karlish
  
  PNAS November 3, 2015 112 (44) 13723-13728; first published October 19, 2015. https://doi.org/10.1073/pnas.1514569112
Plant Biology
- Open Access
  CG gene body DNA methylation changes and evolution of duplicated genes in cassava
  Haifeng Wang, Getu Beyene, Jixian Zhai, Suhua Feng, Noah Fahlgren, Nigel J. Taylor, Rebecca Bart, James C. Carrington, Steven E. Jacobsen, and Israel Ausin
  
  PNAS November 3, 2015 112 (44) 13729-13734; first published October 19, 2015. https://doi.org/10.1073/pnas.1519067112
- Open Access
  The mitochondrial monothiol glutaredoxin S15 is essential for iron-sulfur protein maturation in Arabidopsis thaliana
  Anna Moseler, Isabel Aller, Stephan Wagner, Thomas Nietzel, Jonathan Przybyla-Toscano, Ulrich Mühlenhoff, Roland Lill, Carsten Berndt, Nicolas Rouhier, Markus Schwarzländer, and Andreas J. Meyer
  
  PNAS November 3, 2015 112 (44) 13735-13740; first published October 19, 2015. https://doi.org/10.1073/pnas.1510835112

Corrections (Online Only)

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Correction for Liu et al., Direct evidence that suspensor cells have embryogenic potential that is suppressed by the embryo proper during normal embryogenesis
PNAS November 3, 2015 112 (44) E6078; first published October 26, 2015. https://doi.org/10.1073/pnas.1519530112
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Correction for Song et al., Resolving conflict in eutherian mammal phylogeny using phylogenomics and the multispecies coalescent model
PNAS November 3, 2015 112 (44) E6079; first published October 26, 2015. https://doi.org/10.1073/pnas.1518753112

SI Corrections (Online Only)

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Correction to Supporting Information for Jiang et al., Gene-expression analysis of hair cell regeneration in the zebrafish lateral line
PNAS November 3, 2015 112 (44) E6080; first published October 19, 2015. https://doi.org/10.1073/pnas.1518842112
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Correction to Supporting Information for Carvalho et al., Birth of a new gene on the Y chromosome of Drosophila melanogaster
PNAS November 3, 2015 112 (44) E6081; first published October 19, 2015. https://doi.org/10.1073/pnas.1519463112

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