Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Stochastic electrotransport selectively enhances the transport of highly electromobile molecules

    Sung-Yon Kim, Jae Hun Cho, Evan Murray, Naveed Bakh, Heejin Choi, Kimberly Ohn, Luzdary Ruelas, Austin Hubbert, Meg McCue, Sara L. Vassallo, Philipp J. Keller, and Kwanghun Chung

    PNAS November 17, 2015 112 (46) E6274-E6283; first published November 2, 2015. https://doi.org/10.1073/pnas.1510133112

• Biochemistry

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    Theory for rates, equilibrium constants, and Brønsted slopes in F₁-ATPase single molecule imaging experiments

    Sándor Volkán-Kacsó and Rudolph A. Marcus

    PNAS November 17, 2015 112 (46) 14230-14235; first published October 19, 2015. https://doi.org/10.1073/pnas.1518489112

    See companion article:

    • Brønsted slopes based on single-molecule imaging data help to unveil the chemically coupled rotation in F₁-ATPase

      - Nov 17, 2015
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    Gating mechanisms of a natural anion channelrhodopsin

    Oleg A. Sineshchekov, Elena G. Govorunova, Hai Li, and John L. Spudich

    PNAS November 17, 2015 112 (46) 14236-14241; first published November 2, 2015. https://doi.org/10.1073/pnas.1513602112
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    Structural basis for the binding of tryptophan-based motifs by δ-COP

    Richard J. Suckling, Pak Phi Poon, Sophie M. Travis, Irina V. Majoul, Frederick M. Hughson, Philip R. Evans, Rainer Duden, and David J. Owen

    PNAS November 17, 2015 112 (46) 14242-14247; first published November 2, 2015. https://doi.org/10.1073/pnas.1506186112

• Biophysics and Computational Biology

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    On artifacts in single-molecule force spectroscopy

    Pilar Cossio, Gerhard Hummer, and Attila Szabo

    PNAS November 17, 2015 112 (46) 14248-14253; first published November 4, 2015. https://doi.org/10.1073/pnas.1519633112
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    Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β₂AR

    Rajan Lamichhane, Jeffrey J. Liu, Goran Pljevaljcic, Kate L. White, Edwin van der Schans, Vsevolod Katritch, Raymond C. Stevens, Kurt Wüthrich, and David P. Millar

    PNAS November 17, 2015 112 (46) 14254-14259; first published November 2, 2015. https://doi.org/10.1073/pnas.1519626112
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    High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction

    Jessica L. Thomaston, Mercedes Alfonso-Prieto, Rahel A. Woldeyes, James S. Fraser, Michael L. Klein, Giacomo Fiorin, and William F. DeGrado

    PNAS November 17, 2015 112 (46) 14260-14265; first published November 2, 2015. https://doi.org/10.1073/pnas.1518493112
  • Open Access

    Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer

    Rui Wang, Rebecca L. Stone, Jason T. Kaelber, Ryan H. Rochat, Alpa M. Nick, K. Vinod Vijayan, Vahid Afshar-Kharghan, Michael F. Schmid, Jing-Fei Dong, Anil K. Sood, and Wah Chiu

    PNAS November 17, 2015 112 (46) 14266-14271; first published November 2, 2015. https://doi.org/10.1073/pnas.1518628112
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    Direct real-time detection of the structural and biochemical events in the myosin power stroke

    Joseph M. Muretta, John A. Rohde, Daniel O. Johnsrud, Sinziana Cornea, and David D. Thomas

    PNAS November 17, 2015 112 (46) 14272-14277; first published November 2, 2015. https://doi.org/10.1073/pnas.1514859112

• Cell Biology

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    Temperature compensation and temperature sensation in the circadian clock

    Philip B. Kidd, Michael W. Young, and Eric D. Siggia

    PNAS November 17, 2015 112 (46) E6284-E6292; first published November 2, 2015. https://doi.org/10.1073/pnas.1511215112
  • Open Access

    Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes

    Zhuo Wang, Zhong Deng, Nadia Dahmane, Kevin Tsai, Pu Wang, Dewight R. Williams, Andrew V. Kossenkov, Louise C. Showe, Rugang Zhang, Qihong Huang, José R. Conejo-Garcia, and Paul M. Lieberman

    PNAS November 17, 2015 112 (46) E6293-E6300; first published November 2, 2015. https://doi.org/10.1073/pnas.1505962112
  • Open Access

    JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

    Ming Xu, Tamara Tchkonia, Husheng Ding, Mikolaj Ogrodnik, Ellen R. Lubbers, Tamar Pirtskhalava, Thomas A. White, Kurt O. Johnson, Michael B. Stout, Vojtech Mezera, Nino Giorgadze, Michael D. Jensen, Nathan K. LeBrasseur, and James L. Kirkland

    PNAS November 17, 2015 112 (46) E6301-E6310; first published November 2, 2015. https://doi.org/10.1073/pnas.1515386112
  • Open Access

    Epidermal development, growth control, and homeostasis in the face of centrosome amplification

    Anita Kulukian, Andrew J. Holland, Benjamin Vitre, Shruti Naik, Don W. Cleveland, and Elaine Fuchs

    PNAS November 17, 2015 112 (46) E6311-E6320; first published November 2, 2015. https://doi.org/10.1073/pnas.1518376112

    See companion article:

    • Chronic centrosome amplification without tumorigenesis

      - Nov 17, 2015
  • Open Access

    Chronic centrosome amplification without tumorigenesis

    Benjamin Vitre, Andrew J. Holland, Anita Kulukian, Ofer Shoshani, Maretoshi Hirai, Yin Wang, Marcus Maldonado, Thomas Cho, Jihane Boubaker, Deborah A. Swing, Lino Tessarollo, Sylvia M. Evans, Elaine Fuchs, and Don W. Cleveland

    PNAS November 17, 2015 112 (46) E6321-E6330; first published November 2, 2015. https://doi.org/10.1073/pnas.1519388112

    See companion article:

    • Epidermal development, growth control, and homeostasis in the face of centrosome amplification

      - Nov 17, 2015
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    PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence

    Lisa Ivanschitz, Yuki Takahashi, Florence Jollivet, Olivier Ayrault, Morgane Le Bras, and Hugues de Thé

    PNAS November 17, 2015 112 (46) 14278-14283; first published November 2, 2015. https://doi.org/10.1073/pnas.1507540112

• Developmental Biology

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    The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3

    Xavier Cullere, Eva Plovie, Paul M. Bennett, Calum A. MacRae, and Tanya N. Mayadas

    PNAS November 17, 2015 112 (46) 14284-14289; first published November 4, 2015. https://doi.org/10.1073/pnas.1510495112

• Ecology

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    Fat, weather, and date affect migratory songbirds’ departure decisions, routes, and time it takes to cross the Gulf of Mexico

    Jill L. Deppe, Michael P. Ward, Rachel T. Bolus, Robert H. Diehl, Antonio Celis-Murillo, Theodore J. Zenzal Jr., Frank R. Moore, Thomas J. Benson, Jaclyn A. Smolinsky, Lynn N. Schofield, David A. Enstrom, Eben H. Paxton, Gil Bohrer, Tara A. Beveroth, Arlo Raim, Renee L. Obringer, David Delaney, and William W. Cochran

    PNAS November 17, 2015 112 (46) E6331-E6338; first published November 2, 2015. https://doi.org/10.1073/pnas.1503381112
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    Persistent impacts of West Nile virus on North American bird populations

    • From the Cover

    T. Luke George, Ryan J. Harrigan, Joseph A. LaManna, David F. DeSante, James F. Saracco, and Thomas B. Smith

    PNAS November 17, 2015 112 (46) 14290-14294; first published November 2, 2015. https://doi.org/10.1073/pnas.1507747112
  • Open Access

    Facilitation shifts paradigms and can amplify coastal restoration efforts

    Brian R. Silliman, Elizabeth Schrack, Qiang He, Rebecca Cope, Amanda Santoni, Tjisse van der Heide, Ralph Jacobi, Mike Jacobi, and Johan van de Koppel

    PNAS November 17, 2015 112 (46) 14295-14300; first published November 2, 2015. https://doi.org/10.1073/pnas.1515297112

• Environmental Sciences

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    Seasonal fluxes of carbonyl sulfide in a midlatitude forest

    Róisín Commane, Laura K. Meredith, Ian T. Baker, Joseph A. Berry, J. William Munger, Stephen A. Montzka, Pamela H. Templer, Stephanie M. Juice, Mark S. Zahniser, and Steven C. Wofsy

    PNAS November 17, 2015 112 (46) 14162-14167; first published November 2, 2015. https://doi.org/10.1073/pnas.1504131112
  • Open Access

    Life and extinction of megafauna in the ice-age Arctic

    Daniel H. Mann, Pamela Groves, Richard E. Reanier, Benjamin V. Gaglioti, Michael L. Kunz, and Beth Shapiro

    PNAS November 17, 2015 112 (46) 14301-14306; first published November 2, 2015. https://doi.org/10.1073/pnas.1516573112

• Evolution

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    Community rescue in experimental metacommunities

    Etienne Low-Décarie, Marcus Kolber, Paige Homme, Andrea Lofano, Alex Dumbrell, Andrew Gonzalez, and Graham Bell

    PNAS November 17, 2015 112 (46) 14307-14312; first published November 2, 2015. https://doi.org/10.1073/pnas.1513125112

• Genetics

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    Genome-wide redistribution of H3K27me3 is linked to genotoxic stress and defective growth

    Evelina Y. Basenko, Takahiko Sasaki, Lexiang Ji, Cameron J. Prybol, Rachel M. Burckhardt, Robert J. Schmitz, and Zachary A. Lewis

    PNAS November 17, 2015 112 (46) E6339-E6348; first published November 2, 2015. https://doi.org/10.1073/pnas.1511377112

• Immunology and Inflammation

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    Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation

    Jun-Bao Fan, Sayuri Miyauchi-Ishida, Kei-ichiro Arimoto, Dan Liu, Ming Yan, Chang-Wei Liu, Balázs Győrffy, and Dong-Er Zhang

    PNAS November 17, 2015 112 (46) 14313-14318; first published October 29, 2015. https://doi.org/10.1073/pnas.1505690112
  • Open Access

    An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice

    Marieta M. Ruseva, Valeria Ramaglia, B. Paul Morgan, and Claire L. Harris

    PNAS November 17, 2015 112 (46) 14319-14324; first published November 2, 2015. https://doi.org/10.1073/pnas.1513698112

• Medical Sciences

  • Open Access

    Automatic classification of prostate cancer Gleason scores from multiparametric magnetic resonance images

    Duc Fehr, Harini Veeraraghavan, Andreas Wibmer, Tatsuo Gondo, Kazuhiro Matsumoto, Herbert Alberto Vargas, Evis Sala, Hedvig Hricak, and Joseph O. Deasy

    PNAS November 17, 2015 112 (46) E6265-E6273; first published November 2, 2015. https://doi.org/10.1073/pnas.1505935112
  • Open Access

    Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis

    Beng Hooi Phang, Rashidah Othman, Gaelle Bougeard, Ren Hui Chia, Thierry Frebourg, Choong Leong Tang, Peh Yean Cheah, and Kanaga Sabapathy

    PNAS November 17, 2015 112 (46) E6349-E6358; first published November 2, 2015. https://doi.org/10.1073/pnas.1510043112
  • Open Access

    Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes

    Sriram Sundaravel, Ryan Duggan, Tushar Bhagat, David L. Ebenezer, Hui Liu, Yiting Yu, Matthias Bartenstein, Madhu Unnikrishnan, Subhradip Karmakar, Ting-Chun Liu, Ingrid Torregroza, Thomas Quenon, John Anastasi, Kathy L. McGraw, Andrea Pellagatti, Jacqueline Boultwood, Vijay Yajnik, Andrew Artz, Michelle M. Le Beau, Ulrich Steidl, Alan F. List, Todd Evans, Amit Verma, and Amittha Wickrema

    PNAS November 17, 2015 112 (46) E6359-E6368; first published November 2, 2015. https://doi.org/10.1073/pnas.1516394112
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    Kinetics methods for clinical epidemiology problems

    Alexandru Dan Corlan and John Ross

    PNAS November 17, 2015 112 (46) 14150-14155; first published November 2, 2015. https://doi.org/10.1073/pnas.1510927112
  • Open Access

    Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients

    Sara M. Tolaney, Yves Boucher, Dan G. Duda, John D. Martin, Giorgio Seano, Marek Ancukiewicz, William T. Barry, Shom Goel, Johanna Lahdenrata, Steven J. Isakoff, Eren D. Yeh, Saloni R. Jain, Mehra Golshan, Jane Brock, Matija Snuderl, Eric P. Winer, Ian E. Krop, and Rakesh K. Jain

    PNAS November 17, 2015 112 (46) 14325-14330; first published November 2, 2015. https://doi.org/10.1073/pnas.1518808112

• Microbiology

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    Deciphering tissue-induced Klebsiella pneumoniae lipid A structure

    Enrique Llobet, Verónica Martínez-Moliner, David Moranta, Käthe M. Dahlström, Verónica Regueiro, Anna Tomás, Victoria Cano, Camino Pérez-Gutiérrez, Christian G. Frank, Helena Fernández-Carrasco, José Luis Insua, Tiina A. Salminen, Junkal Garmendia, and José A. Bengoechea

    PNAS November 17, 2015 112 (46) E6369-E6378; first published November 2, 2015. https://doi.org/10.1073/pnas.1508820112
  • Open Access

    Role of HIV-1 matrix protein p17 variants in lymphoma pathogenesis

    Riccardo Dolcetti, Cinzia Giagulli, Wangxiao He, Marina Selleri, Francesca Caccuri, Lindsay M. Eyzaguirre, Pietro Mazzuca, Silvia Corbellini, Federica Campilongo, Stefania Marsico, Emanuela Giombini, Elena Muraro, Gabriella Rozera, Paolo De Paoli, Antonino Carbone, Maria Rosaria Capobianchi, Giuseppe Ippolito, Simona Fiorentini, William A. Blattner, Wuyuan Lu, Robert C. Gallo, and Arnaldo Caruso

    PNAS November 17, 2015 112 (46) 14331-14336; first published November 2, 2015. https://doi.org/10.1073/pnas.1514748112
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    The adherens junctions control susceptibility to Staphylococcus aureus α-toxin

    • From the Cover

    Lauren M. Popov, Caleb D. Marceau, Philipp M. Starkl, Jennifer H. Lumb, Jimit Shah, Diego Guerrera, Rachel L. Cooper, Christina Merakou, Donna M. Bouley, Wenxiang Meng, Hiroshi Kiyonari, Masatoshi Takeichi, Stephen J. Galli, Fabio Bagnoli, Sandra Citi, Jan E. Carette, and Manuel R. Amieva

    PNAS November 17, 2015 112 (46) 14337-14342; first published October 21, 2015. https://doi.org/10.1073/pnas.1510265112

    See companion article:

    • The ever-emerging complexity of α-toxin’s interaction with host cells

      - Nov 17, 2015
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    Bacterial clade with the ribosomal RNA operon on a small plasmid rather than the chromosome

    Mizue Anda, Yoshiyuki Ohtsubo, Takashi Okubo, Masayuki Sugawara, Yuji Nagata, Masataka Tsuda, Kiwamu Minamisawa, and Hisayuki Mitsui

    PNAS November 17, 2015 112 (46) 14343-14347; first published November 3, 2015. https://doi.org/10.1073/pnas.1514326112

• Neuroscience

  • Open Access

    Diversity of sharp-wave–ripple LFP signatures reveals differentiated brain-wide dynamical events

    Juan F. Ramirez-Villegas, Nikos K. Logothetis, and Michel Besserve

    PNAS November 17, 2015 112 (46) E6379-E6387; first published November 4, 2015. https://doi.org/10.1073/pnas.1518257112

• Physiology

  • Open Access

    Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring

    Min Hu, Jennifer Elise Richard, Manuel Maliqueo, Milana Kokosar, Romina Fornes, Anna Benrick, Thomas Jansson, Claes Ohlsson, Xiaoke Wu, Karolina Patrycja Skibicka, and Elisabet Stener-Victorin

    PNAS November 17, 2015 112 (46) 14348-14353; first published November 2, 2015. https://doi.org/10.1073/pnas.1507514112

• Plant Biology

  • Open Access

    Plant Raf-like kinase integrates abscisic acid and hyperosmotic stress signaling upstream of SNF1-related protein kinase2

    Masashi Saruhashi, Totan Kumar Ghosh, Kenta Arai, Yumiko Ishizaki, Kazuya Hagiwara, Kenji Komatsu, Yuh Shiwa, Keiichi Izumikawa, Harunori Yoshikawa, Taishi Umezawa, Yoichi Sakata, and Daisuke Takezawa

    PNAS November 17, 2015 112 (46) E6388-E6396; first published November 4, 2015. https://doi.org/10.1073/pnas.1511238112
  • Open Access

    Hormone-regulated defense and stress response networks contribute to heterosis in Arabidopsis F1 hybrids

    Michael Groszmann, Rebeca Gonzalez-Bayon, Rebecca L. Lyons, Ian K. Greaves, Kemal Kazan, W. James Peacock, and Elizabeth S. Dennis

    PNAS November 17, 2015 112 (46) E6397-E6406; first published November 2, 2015. https://doi.org/10.1073/pnas.1519926112
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    Host target modification as a strategy to counter pathogen hijacking of the jasmonate hormone receptor

    Li Zhang, Jian Yao, John Withers, Xiu-Fang Xin, Rahul Banerjee, Qazi Fariduddin, Yoko Nakamura, Kinya Nomura, Gregg A. Howe, Wilhelm Boland, Honggao Yan, and Sheng Yang He

    PNAS November 17, 2015 112 (46) 14354-14359; first published November 2, 2015. https://doi.org/10.1073/pnas.1510745112
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    Unique COPII component AtSar1a/AtSec23a pair is required for the distinct function of protein ER export in Arabidopsis thaliana

    Yonglun Zeng, Kin Pan Chung, Baiying Li, Ching Man Lai, Sheung Kwan Lam, Xiangfeng Wang, Yong Cui, Caiji Gao, Ming Luo, Kam-Bo Wong, Randy Schekman, and Liwen Jiang

    PNAS November 17, 2015 112 (46) 14360-14365; first published November 2, 2015. https://doi.org/10.1073/pnas.1519333112

• Population Biology

  • Open Access

    Measuring the impact of Ebola control measures in Sierra Leone

    • From the Cover

    Adam J. Kucharski, Anton Camacho, Stefan Flasche, Rebecca E. Glover, W. John Edmunds, and Sebastian Funk

    PNAS November 17, 2015 112 (46) 14366-14371; first published October 12, 2015. https://doi.org/10.1073/pnas.1508814112

    See companion article:

    • Impact of bed capacity on spatiotemporal shifts in Ebola transmission

      - Nov 17, 2015

• Psychological and Cognitive Sciences

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    Training conquers multitasking costs by dividing task representations in the frontoparietal-subcortical system

    • From the Cover

    K. G. Garner and Paul E. Dux

    PNAS November 17, 2015 112 (46) 14372-14377; first published October 12, 2015. https://doi.org/10.1073/pnas.1511423112

    See companion article:

    • Training refines brain representations for multitasking

      - Nov 17, 2015
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    The human hippocampus contributes to both the recollection and familiarity components of recognition memory

    Maxwell B. Merkow, John F. Burke, and Michael J. Kahana

    PNAS November 17, 2015 112 (46) 14378-14383; first published November 2, 2015. https://doi.org/10.1073/pnas.1513145112

• Sustainability Science

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    Allowing variance may enlarge the safe operating space for exploited ecosystems

    Stephen R. Carpenter, William A. Brock, Carl Folke, Egbert H. van Nes, and Marten Scheffer

    PNAS November 17, 2015 112 (46) 14384-14389; first published October 5, 2015. https://doi.org/10.1073/pnas.1511804112

    See companion article:

    • Managing variance: Key policy challenges for the Anthropocene

      - Nov 24, 2015
  • Open Access

    An analysis of ozone damage to historical maize and soybean yields in the United States

    Justin M. McGrath, Amy M. Betzelberger, Shaowen Wang, Eric Shook, Xin-Guang Zhu, Stephen P. Long, and Elizabeth A. Ainsworth

    PNAS November 17, 2015 112 (46) 14390-14395; first published November 2, 2015. https://doi.org/10.1073/pnas.1509777112